locus-tag	class	description
INT76_RS00005	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
INT76_RS00015	COG0110	maltose O-acetyltransferase activity
INT76_RS00040	COG3475	LICD family
INT76_RS00045	COG4750	Nucleotidyl transferase
INT76_RS00055	COG4750	Nucleotidyl transferase
INT76_RS00070	COG1846	Transcriptional regulator
INT76_RS00080	COG0436	Aminotransferase
INT76_RS00090	COG0534	Mate efflux family protein
INT76_RS00095	COG0251	oxidation-reduction process
INT76_RS00100	COG1660	Displays ATPase and GTPase activities
INT76_RS00105	COG0391	Required for morphogenesis under gluconeogenic growth conditions
INT76_RS00110	COG1481	regulation of sporulation
INT76_RS00115	COG0335	large ribosomal subunit rRNA binding
INT76_RS00130	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
INT76_RS00135	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
INT76_RS00150	COG0716	FMN binding
INT76_RS00155	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
INT76_RS00170	COG0254	rRNA binding
INT76_RS00175	COG0772	Belongs to the SEDS family
INT76_RS00180	COG0693	protein deglycase activity
INT76_RS00185	COG0187	DNA topoisomerase II activity
INT76_RS00190	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
INT76_RS00200	COG0072	phenylalanine-tRNA ligase activity
INT76_RS00200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
INT76_RS00220	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
INT76_RS00235	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
INT76_RS00240	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
INT76_RS00250	COG1234	tRNA 3'-trailer cleavage
INT76_RS00255	COG0300	oxidoreductase activity
INT76_RS00265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
INT76_RS00270	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
INT76_RS00270	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
INT76_RS00285	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
INT76_RS00290	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
INT76_RS00300	COG2384	SAM-dependent methyltransferase
INT76_RS00305	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
INT76_RS00315	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
INT76_RS00330	COG1088	dTDP-glucose 4,6-dehydratase activity
INT76_RS00335	COG1091	dTDP-4-dehydrorhamnose reductase activity
INT76_RS00350	COG1215	transferase activity, transferring glycosyl groups
INT76_RS00380	COG0463	Glycosyl transferase, family 2
INT76_RS00405	COG1141	Ferredoxin
INT76_RS00415	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
INT76_RS00425	COG0291	Belongs to the bacterial ribosomal protein bL35 family
INT76_RS00440	COG1368	sulfuric ester hydrolase activity
INT76_RS00445	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
INT76_RS00450	COG0710	3-dehydroquinate dehydratase activity
INT76_RS00460	COG0287	Prephenate dehydrogenase
INT76_RS00465	COG3679	Belongs to the UPF0342 family
INT76_RS00480	COG4120	Belongs to the binding-protein-dependent transport system permease family
INT76_RS00485	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
INT76_RS00485	COG1116	anion transmembrane transporter activity
INT76_RS00500	COG1028	Short-chain dehydrogenase reductase Sdr
INT76_RS00505	COG0738	Major facilitator superfamily
INT76_RS00510	COG0738	Major facilitator superfamily
INT76_RS00515	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
INT76_RS00525	COG2851	Citrate transporter
INT76_RS00530	COG0710	3-dehydroquinate dehydratase activity
INT76_RS00535	COG1902	pentaerythritol trinitrate reductase activity
INT76_RS00540	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
INT76_RS00545	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
INT76_RS00550	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
INT76_RS00555	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
INT76_RS00560	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
INT76_RS00570	COG0077	Prephenate dehydratase
INT76_RS00580	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
INT76_RS00630	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
INT76_RS00640	COG1518	maintenance of DNA repeat elements
INT76_RS00655	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
INT76_RS00660	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
INT76_RS00665	COG1393	Belongs to the ArsC family
INT76_RS00675	COG2267	carboxylic ester hydrolase activity
INT76_RS00680	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
INT76_RS00685	COG0813	purine-nucleoside phosphorylase activity
INT76_RS00690	COG0058	SHG alpha-glucan phosphorylase activity
INT76_RS00695	COG0635	Involved in the biosynthesis of porphyrin-containing compound
INT76_RS00705	COG1051	belongs to the nudix hydrolase family
INT76_RS00710	COG0647	UMP catabolic process
INT76_RS00720	COG0828	Belongs to the bacterial ribosomal protein bS21 family
INT76_RS00725	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
INT76_RS00730	COG1970	mechanosensitive ion channel activity
INT76_RS00735	COG0358	DNA primase activity
INT76_RS00740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
INT76_RS00745	COG2151	metal-sulfur cluster biosynthetic enzyme
INT76_RS00750	COG1982	Orn Lys Arg decarboxylase major
INT76_RS00755	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
INT76_RS00795	COG1131	(ABC) transporter
INT76_RS00800	COG4585	Histidine kinase
INT76_RS00825	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
INT76_RS00835	COG1131	(ABC) transporter
INT76_RS00840	COG2188	Transcriptional regulator
INT76_RS00850	COG0205	6-phosphofructokinase activity
INT76_RS00855	COG0469	pyruvate kinase activity
INT76_RS00860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INT76_RS00870	COG0210	DNA helicase
INT76_RS00875	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
INT76_RS00880	COG1074	ATP-dependent DNA helicase activity
INT76_RS00890	COG0481	GTPase activity
INT76_RS00895	COG0561	phosphatase activity
INT76_RS00920	COG1011	Hydrolase
INT76_RS00925	COG1876	peptidase activity
INT76_RS00940	COG1131	(ABC) transporter
INT76_RS00960	COG3209	COG3209 Rhs family protein
INT76_RS00995	COG0488	(ABC) transporter
INT76_RS01005	COG1620	l-lactate permease
INT76_RS01035	COG1126	abc transporter atp-binding protein
INT76_RS01050	COG3583	domain protein
INT76_RS01055	COG3583	domain protein
INT76_RS01075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INT76_RS01085	COG0297	glycogen (starch) synthase activity
INT76_RS01090	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
INT76_RS01095	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
INT76_RS01100	COG0583	DNA-binding transcription factor activity
INT76_RS01105	COG0543	2 iron, 2 sulfur cluster binding
INT76_RS01110	COG0167	dihydroorotate dehydrogenase activity
INT76_RS01135	COG0463	Glycosyl transferase, family 2
INT76_RS01145	COG1051	belongs to the nudix hydrolase family
INT76_RS01155	COG0737	Belongs to the 5'-nucleotidase family
INT76_RS01160	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
INT76_RS01165	COG0187	DNA topoisomerase II activity
INT76_RS01180	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
INT76_RS01200	COG0539	negative regulation of cytoplasmic translation
INT76_RS01220	COG1104	cysteine desulfurase activity
INT76_RS01225	COG0301	tRNA thio-modification
INT76_RS01230	COG1114	Component of the transport system for branched-chain amino acids
INT76_RS01235	COG0261	This protein binds to 23S rRNA in the presence of protein L20
INT76_RS01240	COG0211	Belongs to the bacterial ribosomal protein bL27 family
INT76_RS01250	COG0583	DNA-binding transcription factor activity
INT76_RS01260	COG0564	pseudouridine synthase activity
INT76_RS01270	COG2824	Alkylphosphonate utilization operon protein PhnA
INT76_RS01280	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
INT76_RS01285	COG0540	Belongs to the ATCase OTCase family
INT76_RS01290	COG0505	Belongs to the CarA family
INT76_RS01310	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
INT76_RS01335	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
INT76_RS01345	COG1349	DNA-binding transcription factor activity
INT76_RS01350	COG1105	Belongs to the carbohydrate kinase PfkB family
INT76_RS01355	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
INT76_RS01355	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
INT76_RS01355	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
INT76_RS01365	COG1307	EDD domain protein, DegV family
INT76_RS01370	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
INT76_RS01375	COG0617	tRNA 3'-terminal CCA addition
INT76_RS01380	COG0488	(ABC) transporter
INT76_RS01390	COG1940	carbohydrate kinase activity
INT76_RS01395	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
INT76_RS01400	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
INT76_RS01410	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
INT76_RS01420	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
INT76_RS01455	COG0083	homoserine kinase activity
INT76_RS01460	COG0812	UDP-N-acetylmuramate dehydrogenase activity
INT76_RS01465	COG3842	ATPase activity
INT76_RS01470	COG1176	ABC-type spermidine putrescine transport system, permease component I
INT76_RS01475	COG1177	transmembrane transport
INT76_RS01480	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
INT76_RS01485	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
INT76_RS01495	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
INT76_RS01505	COG0534	Mate efflux family protein
INT76_RS01530	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
INT76_RS01535	COG2890	protein-(glutamine-N5) methyltransferase activity
INT76_RS01540	COG0009	L-threonylcarbamoyladenylate synthase
INT76_RS01550	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
INT76_RS01565	COG4221	oxidoreductase activity
INT76_RS01585	COG2188	Transcriptional regulator
INT76_RS01595	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
INT76_RS01600	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
INT76_RS01620	COG4974	Belongs to the 'phage' integrase family
INT76_RS01630	COG5002	protein histidine kinase activity
INT76_RS01635	COG0745	RESPONSE REGULATOR receiver
INT76_RS01655	COG1136	(ABC) transporter
INT76_RS01695	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
INT76_RS01705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INT76_RS01710	COG0758	DNA mediated transformation
INT76_RS01715	COG1940	carbohydrate kinase activity
INT76_RS01720	COG0110	maltose O-acetyltransferase activity
INT76_RS01725	COG1937	Protein conserved in bacteria
INT76_RS01730	COG1054	Belongs to the UPF0176 family
INT76_RS01735	COG0446	pyridine nucleotide-disulphide oxidoreductase
INT76_RS01760	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
INT76_RS01765	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
INT76_RS01770	COG0583	DNA-binding transcription factor activity
INT76_RS01780	COG0656	L-ascorbic acid biosynthetic process
INT76_RS01785	COG0656	L-ascorbic acid biosynthetic process
INT76_RS01790	COG0667	Aldo Keto reductase
INT76_RS01800	COG2873	o-acetylhomoserine
INT76_RS01805	COG0604	alcohol dehydrogenase
INT76_RS01815	COG1164	Oligoendopeptidase f
INT76_RS01830	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
INT76_RS01870	COG0653	protein targeting
INT76_RS01895	COG1442	glycosyl transferase family 8
INT76_RS01895	COG1216	Glycosyl transferase, family 2
INT76_RS01900	COG1442	glycosyl transferase family 8
INT76_RS01900	COG1216	Glycosyl transferase, family 2
INT76_RS01910	COG1442	glycosyl transferase family 8
INT76_RS01915	COG1442	glycosyl transferase family 8
INT76_RS01915	COG1216	Glycosyl transferase, family 2
INT76_RS01925	COG1442	glycosyl transferase family 8
INT76_RS01930	COG1442	glycosyl transferase family 8
INT76_RS01930	COG1216	Glycosyl transferase, family 2
INT76_RS01935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
INT76_RS01940	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
INT76_RS01965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INT76_RS01975	COG0745	RESPONSE REGULATOR receiver
INT76_RS01995	COG2759	Belongs to the formate--tetrahydrofolate ligase family
INT76_RS02005	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
INT76_RS02010	COG4684	Psort location CytoplasmicMembrane, score
INT76_RS02015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
INT76_RS02025	COG1194	a g-specific adenine glycosylase
INT76_RS02030	COG1132	(ABC) transporter
INT76_RS02035	COG1132	(ABC) transporter
INT76_RS02040	COG0280	phosphate acetyltransferase
INT76_RS02045	COG0564	pseudouridine synthase activity
INT76_RS02050	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
INT76_RS02055	COG2357	RelA SpoT domain protein
INT76_RS02070	COG1104	cysteine desulfurase activity
INT76_RS02095	COG3764	Sortase (surface protein transpeptidase)
INT76_RS02100	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
INT76_RS02105	COG0039	L-malate dehydrogenase activity
INT76_RS02110	COG1079	Belongs to the binding-protein-dependent transport system permease family
INT76_RS02115	COG4603	Belongs to the binding-protein-dependent transport system permease family
INT76_RS02120	COG3845	ABC transporter
INT76_RS02125	COG1744	ABC transporter substrate-binding protein PnrA-like
INT76_RS02130	COG0295	cytidine deaminase activity
INT76_RS02145	COG2813	Specifically methylates the guanine in position
INT76_RS02150	COG1072	(Pantothenic acid kinase))
INT76_RS02155	COG0268	Binds directly to 16S ribosomal RNA
INT76_RS02165	COG5002	protein histidine kinase activity
INT76_RS02170	COG0745	RESPONSE REGULATOR receiver
INT76_RS02190	COG0704	Plays a role in the regulation of phosphate uptake
INT76_RS02195	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
INT76_RS02205	COG0581	inorganic phosphate transmembrane transporter activity
INT76_RS02210	COG0573	inorganic phosphate transmembrane transporter activity
INT76_RS02220	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
INT76_RS02220	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
INT76_RS02225	COG0483	inositol monophosphate 1-phosphatase activity
INT76_RS02230	COG4476	Belongs to the UPF0223 family
INT76_RS02235	COG1393	Belongs to the ArsC family
INT76_RS02240	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
INT76_RS02245	COG0196	riboflavin kinase activity
INT76_RS02250	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
INT76_RS02285	COG1704	LemA family
INT76_RS02300	COG0662	Cupin 2, conserved barrel domain protein
INT76_RS02305	COG2226	methyltransferase
INT76_RS02315	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
INT76_RS02325	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
INT76_RS02330	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
INT76_RS02335	COG3442	glutamine amidotransferase
INT76_RS02345	COG2226	methyltransferase
INT76_RS02360	COG0488	(ABC) transporter
INT76_RS02390	COG1122	ATPase activity
INT76_RS02425	COG1293	RNA-binding protein homologous to eukaryotic snRNP
INT76_RS02430	COG3527	Alpha-acetolactate decarboxylase
INT76_RS02440	COG0628	permease
INT76_RS02445	COG2706	6-phosphogluconolactonase activity
INT76_RS02485	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
INT76_RS02490	COG0107	imidazoleglycerol-phosphate synthase activity
INT76_RS02495	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
INT76_RS02500	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
INT76_RS02510	COG0560	Phosphoserine phosphatase
INT76_RS02515	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
INT76_RS02520	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
INT76_RS02525	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
INT76_RS02550	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
INT76_RS02560	COG0355	proton-transporting ATP synthase activity, rotational mechanism
INT76_RS02565	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
INT76_RS02570	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
INT76_RS02575	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
INT76_RS02580	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
INT76_RS02585	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
INT76_RS02590	COG0356	it plays a direct role in the translocation of protons across the membrane
INT76_RS02610	COG0701	Predicted permease
INT76_RS02615	COG3689	TIGRFAM TIGR03943 family protein
INT76_RS02620	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
INT76_RS02635	COG0552	protein localization to endoplasmic reticulum
INT76_RS02640	COG0561	phosphatase activity
INT76_RS02645	COG0561	phosphatase activity
INT76_RS02650	COG1196	nuclear chromosome segregation
INT76_RS02655	COG0571	ribonuclease III activity
INT76_RS02675	COG4868	Belongs to the UPF0371 family
INT76_RS02680	COG1012	belongs to the aldehyde dehydrogenase family
INT76_RS02690	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
INT76_RS02695	COG0538	isocitrate dehydrogenase activity
INT76_RS02700	COG0372	Belongs to the citrate synthase family
INT76_RS02705	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
INT76_RS02710	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
INT76_RS02715	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
INT76_RS02720	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
INT76_RS02740	COG1476	TRANSCRIPTIONal
INT76_RS02755	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
INT76_RS02770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
INT76_RS02775	COG4122	O-methyltransferase activity
INT76_RS02810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
INT76_RS02810	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
INT76_RS02875	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
INT76_RS02885	COG1131	(ABC) transporter
INT76_RS02895	COG4585	Histidine kinase
INT76_RS02900	COG2197	response regulator
INT76_RS02915	COG0640	Transcriptional regulator
INT76_RS02920	COG0708	Exodeoxyribonuclease III
INT76_RS02925	COG1393	Belongs to the ArsC family
INT76_RS02930	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
INT76_RS02935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
INT76_RS02945	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
INT76_RS02955	COG4467	Involved in initiation control of chromosome replication
INT76_RS02960	COG0470	DNA polymerase III
INT76_RS02965	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
INT76_RS02970	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
INT76_RS02975	COG0517	IMP dehydrogenase activity
INT76_RS03000	COG0683	leucine binding
INT76_RS03015	COG1136	(ABC) transporter
INT76_RS03025	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
INT76_RS03030	COG0366	Alpha amylase catalytic
INT76_RS03035	COG0366	Alpha amylase catalytic
INT76_RS03040	COG0395	ABC-type sugar transport system, permease component
INT76_RS03045	COG1175	transmembrane transport
INT76_RS03050	COG1653	transport
INT76_RS03060	COG2207	Transcriptional regulator
INT76_RS03065	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
INT76_RS03070	COG0626	cystathionine gamma-synthase activity
INT76_RS03075	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
INT76_RS03080	COG1120	ATPase activity
INT76_RS03085	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
INT76_RS03090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INT76_RS03095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INT76_RS03100	COG1187	pseudouridine synthase activity
INT76_RS03105	COG0435	Glutathione S-transferase
INT76_RS03110	COG0363	glucosamine-6-phosphate deaminase activity
INT76_RS03120	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
INT76_RS03125	COG1438	arginine binding
INT76_RS03130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
INT76_RS03135	COG1288	antiporter activity
INT76_RS03140	COG0436	Aminotransferase
INT76_RS03150	COG0549	Belongs to the carbamate kinase family
INT76_RS03155	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
INT76_RS03165	COG2235	arginine
INT76_RS03175	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
INT76_RS03180	COG1466	dna polymerase III delta subunit
INT76_RS03185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
INT76_RS03195	COG0583	DNA-binding transcription factor activity
INT76_RS03200	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
INT76_RS03205	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
INT76_RS03210	COG1024	Enoyl-CoA hydratase
INT76_RS03220	COG0183	Belongs to the thiolase family
INT76_RS03225	COG1250	3-hydroxyacyl-CoA dehydrogenase
INT76_RS03230	COG1960	acyl-CoA dehydrogenase activity
INT76_RS03240	COG2030	dehydratase
INT76_RS03245	COG0596	Alpha beta hydrolase
INT76_RS03250	COG3243	poly(R)-hydroxyalkanoic acid synthase
INT76_RS03270	COG0424	maF-like protein
INT76_RS03275	COG2333	competence protein COMEC
INT76_RS03275	COG0658	competence protein
INT76_RS03280	COG1555	photosystem II stabilization
INT76_RS03280	COG1596	polysaccharide export
INT76_RS03285	COG0204	Acyl-transferase
INT76_RS03290	COG2264	protein methyltransferase activity
INT76_RS03295	COG2827	Endonuclease containing a URI domain
INT76_RS03320	COG0577	efflux transmembrane transporter activity
INT76_RS03325	COG1136	(ABC) transporter
INT76_RS03330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INT76_RS03335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INT76_RS03340	COG1268	BioY protein
INT76_RS03345	COG4443	Transcriptional Coactivator p15 (PC4)
INT76_RS03355	COG0826	peptidase U32
INT76_RS03380	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
INT76_RS03385	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
INT76_RS03400	COG3091	SprT-like family
INT76_RS03405	COG2183	response to ionizing radiation
INT76_RS03410	COG4708	membrane
INT76_RS03455	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
INT76_RS03465	COG2131	deaminase
INT76_RS03475	COG1363	Peptidase, m42
INT76_RS03490	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
INT76_RS03495	COG1956	GAF domain-containing protein
INT76_RS03500	COG0066	3-isopropylmalate dehydratase activity
INT76_RS03505	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
INT76_RS03515	COG0473	3-isopropylmalate dehydrogenase activity
INT76_RS03525	COG1695	Transcriptional regulator
INT76_RS03535	COG0673	inositol 2-dehydrogenase activity
INT76_RS03540	COG0513	Belongs to the DEAD box helicase family
INT76_RS03610	COG0183	Belongs to the thiolase family
INT76_RS03615	COG3425	synthase
INT76_RS03625	COG0456	acetyltransferase
INT76_RS03680	COG0582	viral genome integration into host DNA
INT76_RS03685	COG0776	regulation of translation
INT76_RS03695	COG2755	lipolytic protein G-D-S-L family
INT76_RS03700	COG1307	EDD domain protein, DegV family
INT76_RS03705	COG0497	DNA recombination
INT76_RS03710	COG1438	arginine binding
INT76_RS03715	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
INT76_RS03725	COG1722	exodeoxyribonuclease VII activity
INT76_RS03730	COG1570	exodeoxyribonuclease VII activity
INT76_RS03735	COG1755	Isoprenylcysteine carboxyl methyltransferase
INT76_RS03750	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
INT76_RS03755	COG1126	abc transporter atp-binding protein
INT76_RS03760	COG0765	amino acid transport
INT76_RS03765	COG4703	Protein of unknown function (DUF1797)
INT76_RS03780	COG0542	response to heat
INT76_RS03790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
INT76_RS03815	COG3599	regulation of cell shape
INT76_RS03825	COG0762	integral membrane protein
INT76_RS03830	COG1799	cell septum assembly
INT76_RS03835	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
INT76_RS03855	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
INT76_RS03870	COG1217	gtp-binding protein TYPA
INT76_RS03885	COG0561	phosphatase activity
INT76_RS03890	COG2195	Cleaves the N-terminal amino acid of tripeptides
INT76_RS03900	COG3759	membrane
INT76_RS03905	COG1846	Transcriptional regulator
INT76_RS03920	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
INT76_RS03925	COG0246	Mannitol dehydrogenase
INT76_RS03930	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
INT76_RS03935	COG3711	transcriptional antiterminator
INT76_RS03940	COG2213	PTS system mannitol-specific
INT76_RS03945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INT76_RS03950	COG1126	abc transporter atp-binding protein
INT76_RS03955	COG0765	amino acid transport
INT76_RS03975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
INT76_RS04005	COG1028	Short-chain dehydrogenase reductase Sdr
INT76_RS04025	COG1695	Transcriptional regulator
INT76_RS04030	COG0577	efflux transmembrane transporter activity
INT76_RS04035	COG1136	(ABC) transporter
INT76_RS04040	COG2205	protein histidine kinase activity
INT76_RS04045	COG0745	RESPONSE REGULATOR receiver
INT76_RS04060	COG1063	alcohol dehydrogenase
INT76_RS04065	COG0789	Transcriptional regulator
INT76_RS04070	COG1227	inorganic diphosphatase activity
INT76_RS04080	COG1733	regulation of RNA biosynthetic process
INT76_RS04085	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
INT76_RS04090	COG2514	catechol 2,3-dioxygenase activity
INT76_RS04095	COG0789	Transcriptional regulator
INT76_RS04100	COG5504	Zn-dependent protease
INT76_RS04105	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
INT76_RS04110	COG1253	flavin adenine dinucleotide binding
INT76_RS04115	COG1119	ATPase activity
INT76_RS04135	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
INT76_RS04140	COG1242	4 iron, 4 sulfur cluster binding
INT76_RS04150	COG1230	cation diffusion facilitator family transporter
INT76_RS04155	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
INT76_RS04160	COG0133	tryptophan synthase activity
INT76_RS04180	COG4470	Protein conserved in bacteria
INT76_RS04190	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
INT76_RS04195	COG0742	ribosomal rna small subunit methyltransferase
INT76_RS04200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
INT76_RS04205	COG4483	Protein conserved in bacteria
INT76_RS04220	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
INT76_RS04230	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
INT76_RS04230	COG2755	lipolytic protein G-D-S-L family
INT76_RS04235	COG0671	phosphoesterase, PA-phosphatase related
INT76_RS04240	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
INT76_RS04255	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
INT76_RS04260	COG1187	pseudouridine synthase activity
INT76_RS04265	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
INT76_RS04270	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
INT76_RS04275	COG0582	viral genome integration into host DNA
INT76_RS04295	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
INT76_RS04300	COG3763	UPF0154 protein
INT76_RS04310	COG3579	cysteine-type endopeptidase activity
INT76_RS04315	COG0574	Belongs to the PEP-utilizing enzyme family
INT76_RS04315	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
INT76_RS04320	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
INT76_RS04325	COG0517	IMP dehydrogenase activity
INT76_RS04335	COG1040	competence protein
INT76_RS04340	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
INT76_RS04345	COG1739	Uncharacterized protein family UPF0029
INT76_RS04355	COG0577	efflux transmembrane transporter activity
INT76_RS04360	COG1136	(ABC) transporter
INT76_RS04370	COG1098	S1 RNA binding domain
INT76_RS04380	COG2197	response regulator
INT76_RS04385	COG4585	Histidine kinase
INT76_RS04395	COG0515	serine threonine protein kinase
INT76_RS04395	COG2815	serine threonine protein kinase
INT76_RS04400	COG0631	protein serine/threonine phosphatase activity
INT76_RS04405	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
INT76_RS04405	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
INT76_RS04410	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
INT76_RS04415	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
INT76_RS04420	COG1758	RNA polymerase activity
INT76_RS04430	COG1418	mRNA catabolic process
INT76_RS04435	COG1854	S-ribosylhomocysteine lyase activity
INT76_RS04445	COG0116	Belongs to the methyltransferase superfamily
INT76_RS04455	COG3599	regulation of cell shape
INT76_RS04460	COG4474	Belongs to the UPF0398 family
INT76_RS04465	COG3331	DNA recombination
INT76_RS04470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
INT76_RS04475	COG0357	Ribosomal RNA small subunit methyltransferase G
INT76_RS04480	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
INT76_RS04490	COG1215	transferase activity, transferring glycosyl groups
INT76_RS04495	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
INT76_RS04505	COG1122	ATPase activity
INT76_RS04525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
INT76_RS04550	COG2207	Transcriptional regulator
INT76_RS04550	COG3708	Transcriptional regulator
INT76_RS04555	COG4335	DNA alkylation repair
INT76_RS04580	COG1401	restriction endodeoxyribonuclease activity
INT76_RS04585	COG1054	Belongs to the UPF0176 family
INT76_RS04590	COG4720	Psort location CytoplasmicMembrane, score
INT76_RS04600	COG1126	abc transporter atp-binding protein
INT76_RS04605	COG0765	amino acid transport
INT76_RS04610	COG0765	amino acid transport
INT76_RS04615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INT76_RS04630	COG0095	Lipoate-protein ligase
INT76_RS04645	COG2723	6-phospho-beta-galactosidase activity
INT76_RS04660	COG2723	6-phospho-beta-galactosidase activity
INT76_RS04665	COG3394	polysaccharide catabolic process
INT76_RS04670	COG2723	6-phospho-beta-galactosidase activity
INT76_RS04680	COG2207	Transcriptional regulator
INT76_RS04690	COG2272	Belongs to the type-B carboxylesterase lipase family
INT76_RS04700	COG3711	transcriptional antiterminator
INT76_RS04705	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
INT76_RS04715	COG1447	Phosphotransferase system cellobiose-specific component IIA
INT76_RS04720	COG3711	transcriptional antiterminator
INT76_RS04720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
INT76_RS04740	COG2723	6-phospho-beta-galactosidase activity
INT76_RS04755	COG0508	dehydrogenase complex catalyzes the overall conversion of
INT76_RS04760	COG0022	dehydrogenase e1 component
INT76_RS04760	COG0508	dehydrogenase complex catalyzes the overall conversion of
INT76_RS04765	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
INT76_RS04780	COG4842	Belongs to the WXG100 family
INT76_RS04860	COG1674	ftsk spoiiie
INT76_RS04865	COG4499	WXG100 protein secretion system (Wss), protein YukC
INT76_RS04910	COG1129	ABC transporter
INT76_RS04925	COG1132	(ABC) transporter
INT76_RS04930	COG4988	ABC transporter
INT76_RS04935	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
INT76_RS04940	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
INT76_RS04950	COG2740	Nucleic-acid-binding protein implicated in transcription termination
INT76_RS04955	COG0195	Participates in both transcription termination and antitermination
INT76_RS04965	COG0220	tRNA (guanine-N7-)-methyltransferase activity
INT76_RS04975	COG4473	ABC transporter
INT76_RS04980	COG1131	(ABC) transporter
INT76_RS04985	COG0537	adenosine 5'-monophosphoramidase activity
INT76_RS04995	COG1316	TRANSCRIPTIONal
INT76_RS05000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
INT76_RS05005	COG0802	atpase or kinase
INT76_RS05010	COG2252	PERMEase
INT76_RS05015	COG0561	phosphatase activity
INT76_RS05030	COG3715	PTS system
INT76_RS05035	COG3716	PTS system mannose fructose sorbose family IID component
INT76_RS05045	COG0454	-acetyltransferase
INT76_RS05070	COG0439	Biotin carboxylase
INT76_RS05090	COG1028	Short-chain dehydrogenase reductase Sdr
INT76_RS05095	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
INT76_RS05100	COG2070	2-Nitropropane dioxygenase
INT76_RS05110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
INT76_RS05120	COG1024	Enoyl-CoA hydratase
INT76_RS05125	COG0527	aspartate kinase activity
INT76_RS05130	COG3684	Belongs to the aldolase LacD family
INT76_RS05140	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
INT76_RS05145	COG0736	holo-[acyl-carrier-protein] synthase activity
INT76_RS05150	COG0653	protein targeting
INT76_RS05165	COG0803	Belongs to the bacterial solute-binding protein 9 family
INT76_RS05170	COG0544	peptidyl-prolyl cis-trans isomerase activity
INT76_RS05205	COG4475	Protein of unknown function (DUF436)
INT76_RS05215	COG0351	phosphomethylpyrimidine kinase
INT76_RS05230	COG2217	Heavy metal translocating P-type atpase
INT76_RS05240	COG3655	Transcriptional regulator
INT76_RS05245	COG0765	amino acid transport
INT76_RS05250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INT76_RS05260	COG0484	heat shock protein binding
INT76_RS05265	COG0443	Heat shock 70 kDa protein
INT76_RS05270	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
INT76_RS05290	COG1695	Transcriptional regulator
INT76_RS05365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
INT76_RS05370	COG0601	transmembrane transport
INT76_RS05375	COG4608	Belongs to the ABC transporter superfamily
INT76_RS05390	COG1686	Belongs to the peptidase S11 family
INT76_RS05410	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
INT76_RS05415	COG0719	Fe-S assembly protein
INT76_RS05425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INT76_RS05430	COG4862	establishment of competence for transformation
INT76_RS05435	COG1968	undecaprenyl-diphosphatase activity
INT76_RS05440	COG0765	amino acid transport
INT76_RS05445	COG1126	abc transporter atp-binding protein
INT76_RS05460	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
INT76_RS05465	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
INT76_RS05470	COG0440	acetolactate synthase activity
INT76_RS05475	COG0028	Belongs to the TPP enzyme family
INT76_RS05480	COG0463	Glycosyl transferase, family 2
INT76_RS05500	COG0129	dihydroxy-acid dehydratase activity
INT76_RS05510	COG2151	metal-sulfur cluster biosynthetic enzyme
INT76_RS05515	COG0259	pyridoxamine-phosphate oxidase activity
INT76_RS05525	COG0577	efflux transmembrane transporter activity
INT76_RS05530	COG1136	(ABC) transporter
INT76_RS05535	COG2205	protein histidine kinase activity
INT76_RS05540	COG0745	RESPONSE REGULATOR receiver
INT76_RS05570	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
INT76_RS05590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INT76_RS05595	COG0191	fructose-bisphosphate aldolase activity
INT76_RS05605	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
INT76_RS05615	COG1447	Phosphotransferase system cellobiose-specific component IIA
INT76_RS05620	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
INT76_RS05625	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
INT76_RS05625	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
INT76_RS05625	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
INT76_RS05635	COG2723	6-phospho-beta-galactosidase activity
INT76_RS05645	COG3343	RNA polymerase activity
INT76_RS05650	COG0436	Aminotransferase
INT76_RS05665	COG0252	asparaginase activity
INT76_RS05670	COG1136	(ABC) transporter
INT76_RS05695	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
INT76_RS05700	COG3942	CHAP domain
INT76_RS05710	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
INT76_RS05730	COG2222	sugar isomerase
INT76_RS05735	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
INT76_RS05740	COG0584	glycerophosphoryl diester phosphodiesterase
INT76_RS05755	COG1132	(ABC) transporter
INT76_RS05760	COG1132	(ABC) transporter
INT76_RS05780	COG2081	HI0933 family
INT76_RS05785	COG1131	(ABC) transporter
INT76_RS05815	COG0395	ABC-type sugar transport system, permease component
INT76_RS05820	COG1175	transmembrane transport
INT76_RS05830	COG2207	Transcriptional regulator
INT76_RS05835	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
INT76_RS05845	COG1214	PFAM Peptidase M22, glycoprotease
INT76_RS05850	COG5503	Protein of unknown function (DUF1447)
INT76_RS05875	COG0174	glutamine synthetase
INT76_RS05880	COG0789	Transcriptional regulator
INT76_RS05915	COG3843	relaxase mobilization nuclease domain protein
INT76_RS05965	COG1388	LysM domain
INT76_RS05965	COG3942	CHAP domain
INT76_RS06070	COG3590	peptidase
INT76_RS06075	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
INT76_RS06080	COG0049	tRNA binding
INT76_RS06090	COG0459	protein refolding
INT76_RS06105	COG3716	PTS system mannose fructose sorbose family IID component
INT76_RS06130	COG2197	response regulator
INT76_RS06135	COG4585	Histidine kinase
INT76_RS06145	COG0561	phosphatase activity
INT76_RS06155	COG0596	Alpha beta hydrolase
INT76_RS06160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
INT76_RS06165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INT76_RS06175	COG1363	Peptidase, m42
INT76_RS06220	COG4537	Required for transformation and DNA binding
INT76_RS06225	COG1459	type II secretion system
INT76_RS06230	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
INT76_RS06235	COG1619	proteins homologs of microcin C7 resistance protein MccF
INT76_RS06245	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
INT76_RS06250	COG0085	RNA polymerase activity
INT76_RS06255	COG4499	WXG100 protein secretion system (Wss), protein YukC
INT76_RS06255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
INT76_RS06280	COG3682	Transcriptional regulator
INT76_RS06285	COG3443	Belongs to the bacterial solute-binding protein 9 family
INT76_RS06285	COG0803	Belongs to the bacterial solute-binding protein 9 family
INT76_RS06290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INT76_RS06295	COG1121	(ABC) transporter
INT76_RS06400	COG0202	RNA polymerase activity
INT76_RS06410	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
INT76_RS06415	COG0257	Belongs to the bacterial ribosomal protein bL36 family
INT76_RS06420	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
INT76_RS06425	COG0563	adenylate kinase activity
INT76_RS06430	COG0201	protein transport
INT76_RS06440	COG1841	ribosomal large subunit assembly
INT76_RS06445	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
INT76_RS06450	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
INT76_RS06455	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
INT76_RS06460	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
INT76_RS06465	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
INT76_RS06470	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
INT76_RS06475	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
INT76_RS06480	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
INT76_RS06485	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
INT76_RS06490	COG0255	Belongs to the universal ribosomal protein uL29 family
INT76_RS06495	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
INT76_RS06500	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
INT76_RS06505	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
INT76_RS06510	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
INT76_RS06515	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
INT76_RS06520	COG0089	rRNA binding
INT76_RS06525	COG0088	Forms part of the polypeptide exit tunnel
INT76_RS06530	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
INT76_RS06540	COG0546	phosphoglycolate phosphatase activity
INT76_RS06550	COG2255	four-way junction helicase activity
INT76_RS06560	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
INT76_RS06570	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
INT76_RS06575	COG1683	Conserved Protein
INT76_RS06580	COG0151	Belongs to the GarS family
INT76_RS06595	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INT76_RS06600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INT76_RS06605	COG1121	(ABC) transporter
INT76_RS06610	COG0803	Belongs to the bacterial solute-binding protein 9 family
INT76_RS06620	COG1490	D-aminoacyl-tRNA deacylase activity
INT76_RS06630	COG0737	Belongs to the 5'-nucleotidase family
INT76_RS06640	COG1385	rRNA (uridine-N3-)-methyltransferase activity
INT76_RS06670	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
INT76_RS06695	COG3942	CHAP domain
INT76_RS06695	COG1705	Flagellar rod assembly protein muramidase FlgJ
INT76_RS06710	COG0433	COG0433 Predicted ATPase
INT76_RS06760	COG1674	ftsk spoiiie
INT76_RS06825	COG1396	sequence-specific DNA binding
INT76_RS06880	COG0737	Belongs to the 5'-nucleotidase family
INT76_RS06885	COG1328	CTP reductase activity
INT76_RS06900	COG0285	dihydrofolate synthase activity
INT76_RS06915	COG3906	Belongs to the UPF0473 family
INT76_RS06925	COG4472	Bacterial protein of unknown function (DUF965)
INT76_RS06930	COG1393	Belongs to the ArsC family
INT76_RS06950	COG1396	sequence-specific DNA binding
INT76_RS06955	COG0519	Catalyzes the synthesis of GMP from XMP
INT76_RS06960	COG0632	four-way junction helicase activity
INT76_RS06965	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
INT76_RS06980	COG1438	arginine binding
INT76_RS06985	COG0018	arginyl-trna synthetase
INT76_RS06990	COG0138	bifunctional purine biosynthesis protein purh
INT76_RS06995	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
INT76_RS07000	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
INT76_RS07015	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
INT76_RS07020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
INT76_RS07025	COG0416	fatty acid biosynthetic process
INT76_RS07030	COG1381	Involved in DNA repair and RecF pathway recombination
INT76_RS07035	COG0436	Aminotransferase
INT76_RS07040	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
INT76_RS07160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
INT76_RS07170	COG0037	tRNA processing
INT76_RS07185	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
INT76_RS07190	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
INT76_RS07195	COG0193	aminoacyl-tRNA hydrolase activity
INT76_RS07200	COG0012	GTP binding
INT76_RS07220	COG0592	DNA-directed DNA polymerase activity
INT76_RS07225	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
INT76_RS07230	COG1475	DNA binding
INT76_RS07235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
INT76_RS07240	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
INT76_RS07270	COG0488	(ABC) transporter
INT76_RS07275	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
INT76_RS07285	COG0517	IMP dehydrogenase activity
INT76_RS07285	COG0516	GMP reductase activity
INT76_RS07290	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
INT76_RS07295	COG2501	S4 domain
INT76_RS07300	COG0612	Peptidase, M16
INT76_RS07305	COG0612	Peptidase, M16
INT76_RS07310	COG1426	Protein conserved in bacteria
INT76_RS07315	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
INT76_RS07320	COG1122	ATPase activity
INT76_RS07325	COG1122	ATPase activity
INT76_RS07330	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
INT76_RS07340	COG5002	protein histidine kinase activity
INT76_RS07345	COG0745	RESPONSE REGULATOR receiver
INT76_RS07355	COG1760	l-serine dehydratase
INT76_RS07360	COG1760	l-serine dehydratase
INT76_RS07365	COG0482	sulfurtransferase activity
INT76_RS07385	COG1733	regulation of RNA biosynthetic process
INT76_RS07390	COG1051	belongs to the nudix hydrolase family
INT76_RS07405	COG0445	tRNA wobble uridine modification
INT76_RS07415	COG0359	binds to the 23S rRNA
INT76_RS07420	COG0305	Participates in initiation and elongation during chromosome replication
INT76_RS07430	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
INT76_RS07475	COG4989	oxidoreductase activity
INT76_RS07485	COG2153	protein acetylation
INT76_RS07490	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
INT76_RS07495	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
INT76_RS07500	COG1780	Probably involved in ribonucleotide reductase function
INT76_RS07505	COG1523	belongs to the glycosyl hydrolase 13 family
INT76_RS07510	COG1609	Transcriptional regulator
INT76_RS07515	COG5521	maltodextrose utilization protein MalA
INT76_RS07520	COG3833	ABC-type maltose transport systems, permease component
INT76_RS07525	COG1175	transmembrane transport
INT76_RS07530	COG2182	Extracellular solute-binding protein
INT76_RS07535	COG1640	4-alpha-glucanotransferase
INT76_RS07555	COG3942	CHAP domain
INT76_RS07565	COG2189	Belongs to the N(4) N(6)-methyltransferase family
INT76_RS07645	COG1388	LysM domain
INT76_RS07645	COG3942	CHAP domain
INT76_RS07695	COG3843	relaxase mobilization nuclease domain protein
INT76_RS07720	COG0463	Glycosyl transferase, family 2
INT76_RS07745	COG1609	Transcriptional regulator
INT76_RS07750	COG1523	belongs to the glycosyl hydrolase 13 family
INT76_RS07775	COG3623	hexulose-6-phosphate isomerase
INT76_RS07795	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
INT76_RS07830	COG0166	Belongs to the GPI family
INT76_RS07835	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
INT76_RS07850	COG2171	N-acyltransferase activity
INT76_RS07855	COG1473	amidohydrolase
INT76_RS07860	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
INT76_RS07865	COG0457	Tetratricopeptide repeat
INT76_RS07865	COG0705	Rhomboid family
INT76_RS07870	COG1210	Utp--glucose-1-phosphate uridylyltransferase
INT76_RS07875	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
INT76_RS07880	COG1132	(ABC) transporter
INT76_RS07885	COG1132	(ABC) transporter
INT76_RS07895	COG0431	NADPH-dependent FMN reductase
INT76_RS07895	COG3976	FMN-binding domain protein
INT76_RS07895	COG1053	succinate dehydrogenase
INT76_RS07905	COG2832	Protein of unknown function (DUF454)
INT76_RS07915	COG0756	dUTP diphosphatase activity
INT76_RS07955	COG1131	(ABC) transporter
INT76_RS07975	COG3655	Transcriptional regulator
INT76_RS07980	COG0833	amino acid
INT76_RS07985	COG2040	homocysteine
INT76_RS08000	COG0494	nUDIX hydrolase
INT76_RS08005	COG0137	argininosuccinate synthase activity
INT76_RS08015	COG0594	ribonuclease P activity
INT76_RS08040	COG0230	Belongs to the bacterial ribosomal protein bL34 family
INT76_RS08045	COG0561	phosphatase activity
INT76_RS08050	COG0084	hydrolase, TatD family'
INT76_RS08095	COG3730	PTS system glucitol sorbitol-specific
INT76_RS08100	COG3732	PTS system glucitol sorbitol-specific
INT76_RS08105	COG3731	PTS system glucitol sorbitol-specific IIA component
INT76_RS08115	COG1162	GTPase activity
INT76_RS08125	COG1564	THIamine pyrophosphokinase
INT76_RS08145	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
INT76_RS08155	COG0564	pseudouridine synthase activity
INT76_RS08160	COG0492	ferredoxin-NADP+ reductase activity
INT76_RS08165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
INT76_RS08170	COG0267	Belongs to the bacterial ribosomal protein bL33 family
INT76_RS08195	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
INT76_RS08210	COG4463	regulation of RNA biosynthetic process
INT76_RS08215	COG0542	response to heat
INT76_RS08220	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
INT76_RS08235	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
INT76_RS08240	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
INT76_RS08245	COG2918	glutathione biosynthetic process
INT76_RS08245	COG1181	Belongs to the D-alanine--D-alanine ligase family
INT76_RS08255	COG1862	Preprotein translocase
INT76_RS08260	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
INT76_RS08265	COG4589	Belongs to the CDS family
INT76_RS08270	COG0750	zinc metalloprotease
INT76_RS08275	COG0442	prolyl-tRNA aminoacylation
INT76_RS08280	COG2176	DNA-directed DNA polymerase activity
INT76_RS08285	COG2309	aminopeptidase activity
INT76_RS08290	COG2261	transglycosylase associated protein
INT76_RS08295	COG0242	peptide deformylase activity
INT76_RS08305	COG1187	pseudouridine synthase activity
INT76_RS08320	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
INT76_RS08335	COG1185	polyribonucleotide nucleotidyltransferase activity
INT76_RS08340	COG1045	serine acetyltransferase
INT76_RS08350	COG0813	purine-nucleoside phosphorylase activity
INT76_RS08365	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
INT76_RS08375	COG3842	ATPase activity
INT76_RS08390	COG0227	Belongs to the bacterial ribosomal protein bL28 family
INT76_RS08410	COG0629	single-stranded DNA binding
INT76_RS08415	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
INT76_RS08435	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
INT76_RS08445	COG0006	proline dipeptidase activity
INT76_RS08460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
INT76_RS08465	COG1621	beta-fructofuranosidase activity
INT76_RS08470	COG1609	Transcriptional regulator
INT76_RS08475	COG1621	beta-fructofuranosidase activity
INT76_RS08480	COG1263	PTS System
INT76_RS08480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
INT76_RS08480	COG2190	(PTS) system
INT76_RS08485	COG1940	carbohydrate kinase activity
INT76_RS08490	COG1482	cell wall glycoprotein biosynthetic process
INT76_RS08495	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
INT76_RS08495	COG3583	domain protein
INT76_RS08500	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
INT76_RS08505	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
INT76_RS08510	COG0154	amidase activity
INT76_RS08515	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
INT76_RS08530	COG1609	Transcriptional regulator
INT76_RS08535	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
INT76_RS08540	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
INT76_RS08550	COG3142	Participates in the control of copper homeostasis
INT76_RS08560	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
INT76_RS08565	COG1534	Rna-binding protein
INT76_RS08570	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
INT76_RS08575	COG1713	HD superfamily hydrolase involved in NAD metabolism
INT76_RS08585	COG1335	isochorismatase
INT76_RS08590	COG0799	negative regulation of ribosome biogenesis
INT76_RS08600	COG2226	methyltransferase
INT76_RS08610	COG0242	peptide deformylase activity
INT76_RS08615	COG1882	Formate acetyltransferase
INT76_RS08625	COG1959	2 iron, 2 sulfur cluster binding
INT76_RS08630	COG2910	NAD(P)H-binding
INT76_RS08640	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
INT76_RS08645	COG0681	Belongs to the peptidase S26 family
INT76_RS08670	COG0366	Alpha amylase catalytic
INT76_RS08675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
INT76_RS08675	COG1263	PTS System
INT76_RS08680	COG2188	Transcriptional regulator
INT76_RS08695	COG1193	negative regulation of DNA recombination
INT76_RS08705	COG3118	belongs to the thioredoxin family
INT76_RS08710	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
INT76_RS08710	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
INT76_RS08715	COG0668	transmembrane transport
INT76_RS08730	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
INT76_RS08735	COG0167	dihydroorotate dehydrogenase activity
INT76_RS08765	COG1136	(ABC) transporter
INT76_RS08770	COG0577	efflux transmembrane transporter activity
INT76_RS08775	COG0745	RESPONSE REGULATOR receiver
INT76_RS08780	COG2205	protein histidine kinase activity
INT76_RS08790	COG0646	methionine synthase
INT76_RS08790	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
INT76_RS08795	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
INT76_RS08820	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
INT76_RS08820	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
INT76_RS08870	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
INT76_RS08890	COG0270	DNA (cytosine-5-)-methyltransferase activity
INT76_RS08925	COG4695	Portal protein
INT76_RS08930	COG0740	serine-type endopeptidase activity
INT76_RS09000	COG0860	N-Acetylmuramoyl-L-alanine amidase
INT76_RS09000	COG1388	LysM domain
INT76_RS09025	COG0561	phosphatase activity
INT76_RS09045	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
INT76_RS09050	COG4152	abc transporter atp-binding protein
INT76_RS09055	COG1668	transmembrane transport
INT76_RS09080	COG0494	nUDIX hydrolase
INT76_RS09090	COG1349	DNA-binding transcription factor activity
INT76_RS09095	COG0698	ribose 5-phosphate isomerase
INT76_RS09100	COG0698	ribose 5-phosphate isomerase
INT76_RS09105	COG1105	Belongs to the carbohydrate kinase PfkB family
INT76_RS09110	COG3684	Belongs to the aldolase LacD family
INT76_RS09115	COG3711	transcriptional antiterminator
INT76_RS09125	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
INT76_RS09125	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
INT76_RS09200	COG0267	Belongs to the bacterial ribosomal protein bL33 family
INT76_RS09205	COG0333	Belongs to the bacterial ribosomal protein bL32 family
INT76_RS09215	COG1454	alcohol dehydrogenase
INT76_RS09215	COG1012	belongs to the aldehyde dehydrogenase family
INT76_RS09230	COG0534	Mate efflux family protein
INT76_RS09235	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
INT76_RS09250	COG1304	FMN binding
INT76_RS09260	COG1063	alcohol dehydrogenase
INT76_RS09270	COG1125	glycine betaine transport
INT76_RS09270	COG0517	IMP dehydrogenase activity
INT76_RS09275	COG1174	glycine betaine transport
INT76_RS09295	COG1959	2 iron, 2 sulfur cluster binding
INT76_RS09300	COG1063	alcohol dehydrogenase
INT76_RS09310	COG4221	oxidoreductase activity
INT76_RS09315	COG0446	pyridine nucleotide-disulphide oxidoreductase
INT76_RS09315	COG1902	pentaerythritol trinitrate reductase activity
INT76_RS09325	COG2207	Transcriptional regulator
INT76_RS09330	COG1621	beta-fructofuranosidase activity
INT76_RS09340	COG2910	NAD(P)H-binding
INT76_RS09345	COG1959	2 iron, 2 sulfur cluster binding
INT76_RS09365	COG4753	response regulator
INT76_RS09365	COG2207	Transcriptional regulator
INT76_RS09410	COG1472	Belongs to the glycosyl hydrolase 3 family
INT76_RS09415	COG1454	alcohol dehydrogenase
INT76_RS09420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
INT76_RS09430	COG2211	Major facilitator Superfamily
INT76_RS09440	COG3408	Glycogen debranching enzyme
INT76_RS09460	COG0235	Class ii aldolase
INT76_RS09475	COG3830	Belongs to the UPF0237 family
INT76_RS09480	COG2848	UPF0210 protein
INT76_RS09485	COG0588	phosphoglycerate mutase activity
INT76_RS09500	COG1640	4-alpha-glucanotransferase
INT76_RS09505	COG0058	SHG alpha-glucan phosphorylase activity
INT76_RS09515	COG1640	4-alpha-glucanotransferase
INT76_RS09525	COG1263	PTS System
INT76_RS09525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
INT76_RS09525	COG2190	(PTS) system
INT76_RS09545	COG0217	transcriptional regulatory protein
INT76_RS09550	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
INT76_RS09555	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
INT76_RS09560	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
INT76_RS09565	COG1464	Belongs to the NlpA lipoprotein family
INT76_RS09575	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
INT76_RS09585	COG0656	L-ascorbic acid biosynthetic process
INT76_RS09590	COG2378	regulation of single-species biofilm formation
INT76_RS09610	COG0751	glycine-tRNA ligase activity
INT76_RS09615	COG4224	UPF0291 protein
INT76_RS09630	COG0534	Mate efflux family protein
INT76_RS09635	COG0569	domain protein
INT76_RS09640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
INT76_RS09650	COG1252	NADH dehydrogenase
INT76_RS09655	COG0142	geranyltranstransferase activity
INT76_RS09660	COG4939	FMN-binding domain protein
INT76_RS09700	COG0275	rRNA processing
INT76_RS09710	COG0768	penicillin binding
INT76_RS09715	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INT76_RS09720	COG0513	Belongs to the DEAD box helicase family
INT76_RS09730	COG0492	ferredoxin-NADP+ reductase activity
INT76_RS09740	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
INT76_RS09745	COG0745	RESPONSE REGULATOR receiver
INT76_RS09750	COG0628	permease
INT76_RS09760	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
INT76_RS09770	COG1484	DNA-dependent DNA replication
INT76_RS09780	COG1160	GTP binding
INT76_RS09790	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
INT76_RS09805	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
INT76_RS09815	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
INT76_RS09820	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
INT76_RS09825	COG0706	membrane insertase activity
INT76_RS09830	COG1254	Belongs to the acylphosphatase family
INT76_RS09835	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INT76_RS09890	COG3557	Belongs to the UPF0374 family
INT76_RS09895	COG2137	regulation of response to DNA damage stimulus
INT76_RS09900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
INT76_RS09905	COG2188	Transcriptional regulator
INT76_RS09910	COG2188	Transcriptional regulator
INT76_RS09920	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
INT76_RS09930	COG3716	PTS system mannose fructose sorbose family IID component
INT76_RS09945	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
INT76_RS09950	COG0494	nUDIX hydrolase
INT76_RS09960	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
INT76_RS09985	COG0346	lactoylglutathione lyase activity
INT76_RS10040	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
INT76_RS10055	COG1609	Transcriptional regulator
INT76_RS10060	COG4209	transmembrane transport
INT76_RS10065	COG0395	ABC-type sugar transport system, permease component
INT76_RS10070	COG1653	transport
INT76_RS10075	COG1621	beta-fructofuranosidase activity
INT76_RS10080	COG1674	ftsk spoiiie
INT76_RS10085	COG0346	lactoylglutathione lyase activity
INT76_RS10100	COG0081	regulation of translation
INT76_RS10115	COG2244	polysaccharide biosynthetic process
INT76_RS10120	COG0528	UMP kinase activity
INT76_RS10125	COG0233	cytoplasmic translational termination
INT76_RS10130	COG2996	Protein conserved in bacteria
INT76_RS10150	COG4479	Belongs to the UPF0346 family
INT76_RS10155	COG1702	phosphate starvation-inducible protein PhoH
INT76_RS10160	COG0686	Belongs to the AlaDH PNT family
INT76_RS10165	COG0456	acetyltransferase
INT76_RS10165	COG1846	Transcriptional regulator
INT76_RS10220	COG1132	(ABC) transporter
INT76_RS10225	COG1132	(ABC) transporter
INT76_RS10245	COG1175	transmembrane transport
INT76_RS10250	COG0395	ABC-type sugar transport system, permease component
INT76_RS10265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
INT76_RS10280	COG1737	Transcriptional regulator
INT76_RS10290	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
INT76_RS10295	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
INT76_RS10300	COG0596	Alpha beta hydrolase
INT76_RS10305	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
INT76_RS10310	COG0237	dephospho-CoA kinase activity
INT76_RS10315	COG2814	Major facilitator Superfamily
INT76_RS10320	COG0267	Belongs to the bacterial ribosomal protein bL33 family
INT76_RS10330	COG0557	exoribonuclease II activity
INT76_RS10335	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
INT76_RS10355	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
INT76_RS10375	COG2357	RelA SpoT domain protein
INT76_RS10380	COG0745	RESPONSE REGULATOR receiver
INT76_RS10385	COG5002	protein histidine kinase activity
INT76_RS10400	COG1136	(ABC) transporter
INT76_RS10415	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
INT76_RS10415	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
INT76_RS10425	COG1832	CoA-binding protein
INT76_RS10430	COG0531	amino acid
INT76_RS10440	COG0343	queuine tRNA-ribosyltransferase activity
INT76_RS10450	COG1609	Transcriptional regulator
INT76_RS10455	COG2610	gluconate transmembrane transporter activity
INT76_RS10475	COG0302	gtp cyclohydrolase
INT76_RS10480	COG1051	belongs to the nudix hydrolase family
INT76_RS10490	COG0438	transferase activity, transferring glycosyl groups
INT76_RS10510	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
INT76_RS10525	COG3804	dihydrodipicolinate reductase
INT76_RS10530	COG4978	Transcriptional regulator
INT76_RS10530	COG0789	Transcriptional regulator
INT76_RS10535	COG0765	amino acid transport
INT76_RS10540	COG0765	amino acid transport
INT76_RS10545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INT76_RS10555	COG0745	RESPONSE REGULATOR receiver
INT76_RS10565	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
INT76_RS10570	COG0768	penicillin binding
INT76_RS10580	COG1181	Belongs to the D-alanine--D-alanine ligase family
INT76_RS10595	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
INT76_RS10620	COG1028	Short-chain dehydrogenase reductase Sdr
INT76_RS10635	COG0800	Aldolase
INT76_RS10645	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
INT76_RS10650	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
INT76_RS10660	COG3716	PTS system mannose fructose sorbose family IID component
INT76_RS10670	COG5492	domain, Protein
INT76_RS10680	COG1609	Transcriptional regulator
INT76_RS10690	COG0513	Belongs to the DEAD box helicase family
INT76_RS10710	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
INT76_RS10720	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
INT76_RS10730	COG3859	Proton-coupled thiamine transporter YuaJ
INT76_RS10750	COG0772	Belongs to the SEDS family
INT76_RS10755	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
INT76_RS10775	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
INT76_RS10785	COG3093	addiction module antidote protein HigA
INT76_RS10800	COG0149	triose-phosphate isomerase activity
INT76_RS10815	COG1078	dGTPase activity
INT76_RS10855	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
INT76_RS10865	COG2884	Cell division ATP-binding protein ftsE
INT76_RS10870	COG2177	Part of the ABC transporter FtsEX involved in
INT76_RS10880	COG1199	ATP-dependent helicase activity
INT76_RS10880	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
INT76_RS10885	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
INT76_RS10890	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
INT76_RS10895	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
INT76_RS10915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
INT76_RS10920	COG1272	protein, Hemolysin III
INT76_RS10930	COG3022	response to hydroperoxide
INT76_RS10940	COG4464	protein tyrosine phosphatase activity
INT76_RS10945	COG3944	biosynthesis protein