locus-tag	class	description
N596_RS00075	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N596_RS00080	COG0295	cytidine deaminase activity
N596_RS00110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N596_RS00120	COG0525	valine-tRNA ligase activity
N596_RS00135	COG0494	nUDIX hydrolase
N596_RS00150	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N596_RS00160	COG0742	ribosomal rna small subunit methyltransferase
N596_RS00165	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
N596_RS00170	COG3480	Lon protease (S16) C-terminal proteolytic domain
N596_RS00180	COG0785	Cytochrome C biogenesis protein
N596_RS00190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N596_RS00195	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N596_RS00195	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N596_RS00200	COG4753	response regulator
N596_RS00200	COG2207	Transcriptional regulator
N596_RS00205	COG2972	Histidine kinase
N596_RS00210	COG4470	Protein conserved in bacteria
N596_RS00215	COG0820	rRNA (adenine-C2-)-methyltransferase activity
N596_RS00225	COG0133	tryptophan synthase activity
N596_RS00255	COG1187	pseudouridine synthase activity
N596_RS00260	COG1217	gtp-binding protein TYPA
N596_RS00285	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
N596_RS00295	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
N596_RS00300	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
N596_RS00305	COG1799	cell septum assembly
N596_RS00320	COG3599	regulation of cell shape
N596_RS00325	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
N596_RS00340	COG0494	nUDIX hydrolase
N596_RS00345	COG0542	response to heat
N596_RS00350	COG4703	Protein of unknown function (DUF1797)
N596_RS00355	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
N596_RS00360	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
N596_RS00375	COG1175	transmembrane transport
N596_RS00380	COG0395	ABC-type sugar transport system, permease component
N596_RS00385	COG1621	beta-fructofuranosidase activity
N596_RS00395	COG1722	exodeoxyribonuclease VII activity
N596_RS00405	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
N596_RS00410	COG1438	arginine binding
N596_RS00415	COG0497	DNA recombination
N596_RS00420	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
N596_RS00425	COG1307	EDD domain protein, DegV family
N596_RS00440	COG0588	phosphoglycerate mutase activity
N596_RS00445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N596_RS00445	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N596_RS00450	COG3655	Transcriptional regulator
N596_RS00480	COG0745	RESPONSE REGULATOR receiver
N596_RS00490	COG1136	(ABC) transporter
N596_RS00495	COG0577	efflux transmembrane transporter activity
N596_RS00510	COG1136	(ABC) transporter
N596_RS00515	COG0577	efflux transmembrane transporter activity
N596_RS00520	COG4166	transmembrane transport
N596_RS00525	COG1695	Transcriptional regulator
N596_RS00540	COG1028	Short-chain dehydrogenase reductase Sdr
N596_RS00655	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N596_RS00660	COG0494	nUDIX hydrolase
N596_RS00670	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
N596_RS00680	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
N596_RS00695	COG0708	Exodeoxyribonuclease III
N596_RS00700	COG0768	penicillin binding
N596_RS00705	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
N596_RS00715	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N596_RS00720	COG1051	belongs to the nudix hydrolase family
N596_RS00745	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
N596_RS00765	COG0513	Belongs to the DEAD box helicase family
N596_RS00770	COG1349	DNA-binding transcription factor activity
N596_RS00785	COG3775	system Galactitol-specific IIC component
N596_RS00800	COG0698	ribose 5-phosphate isomerase
N596_RS00805	COG1105	Belongs to the carbohydrate kinase PfkB family
N596_RS00815	COG3684	Belongs to the aldolase LacD family
N596_RS00825	COG2827	Endonuclease containing a URI domain
N596_RS00830	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
N596_RS00835	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
N596_RS00840	COG0204	Acyl-transferase
N596_RS00845	COG1555	photosystem II stabilization
N596_RS00845	COG1596	polysaccharide export
N596_RS00850	COG0658	competence protein
N596_RS00850	COG2333	competence protein COMEC
N596_RS00860	COG1466	dna polymerase III delta subunit
N596_RS00865	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
N596_RS00870	COG0433	COG0433 Predicted ATPase
N596_RS00885	COG2235	arginine
N596_RS00890	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
N596_RS00895	COG0549	Belongs to the carbamate kinase family
N596_RS00900	COG1288	antiporter activity
N596_RS00905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N596_RS00915	COG2801	Transposase and inactivated derivatives
N596_RS00920	COG1438	arginine binding
N596_RS00925	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
N596_RS00945	COG1686	Belongs to the peptidase S11 family
N596_RS00970	COG4122	O-methyltransferase activity
N596_RS00975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N596_RS00985	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N596_RS00990	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N596_RS00995	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N596_RS01000	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N596_RS01015	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
N596_RS01025	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
N596_RS01030	COG0297	glycogen (starch) synthase activity
N596_RS01035	COG3064	Membrane
N596_RS01045	COG0356	it plays a direct role in the translocation of protons across the membrane
N596_RS01050	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
N596_RS01055	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N596_RS01060	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
N596_RS01065	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
N596_RS01085	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N596_RS01110	COG0488	(ABC) transporter
N596_RS01125	COG2814	Major facilitator Superfamily
N596_RS01140	COG3442	glutamine amidotransferase
N596_RS01145	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N596_RS01150	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
N596_RS01160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N596_RS01165	COG4932	domain protein
N596_RS01170	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N596_RS01180	COG0251	oxidation-reduction process
N596_RS01185	COG1660	Displays ATPase and GTPase activities
N596_RS01190	COG0391	Required for morphogenesis under gluconeogenic growth conditions
N596_RS01195	COG1481	regulation of sporulation
N596_RS01200	COG0492	ferredoxin-NADP+ reductase activity
N596_RS01205	COG0492	ferredoxin-NADP+ reductase activity
N596_RS01220	COG0828	Belongs to the bacterial ribosomal protein bS21 family
N596_RS01225	COG1970	mechanosensitive ion channel activity
N596_RS01230	COG0358	DNA primase activity
N596_RS01235	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N596_RS01240	COG2151	metal-sulfur cluster biosynthetic enzyme
N596_RS01245	COG1131	(ABC) transporter
N596_RS01270	COG0469	pyruvate kinase activity
N596_RS01280	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
N596_RS01285	COG0210	DNA helicase
N596_RS01305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N596_RS01310	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
N596_RS01315	COG0196	riboflavin kinase activity
N596_RS01320	COG1393	Belongs to the ArsC family
N596_RS01330	COG0483	inositol monophosphate 1-phosphatase activity
N596_RS01335	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N596_RS01335	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
N596_RS01340	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N596_RS01345	COG0573	inorganic phosphate transmembrane transporter activity
N596_RS01350	COG0581	inorganic phosphate transmembrane transporter activity
N596_RS01355	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N596_RS01360	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N596_RS01365	COG0704	Plays a role in the regulation of phosphate uptake
N596_RS01375	COG1268	BioY protein
N596_RS01385	COG0745	RESPONSE REGULATOR receiver
N596_RS01390	COG5002	protein histidine kinase activity
N596_RS01400	COG0726	polysaccharide deacetylase
N596_RS01410	COG0673	inositol 2-dehydrogenase activity
N596_RS01425	COG1956	GAF domain-containing protein
N596_RS01430	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
N596_RS01440	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
N596_RS01440	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
N596_RS01445	COG1609	Transcriptional regulator
N596_RS01450	COG2207	Transcriptional regulator
N596_RS01455	COG3345	alpha-galactosidase
N596_RS01460	COG1653	transport
N596_RS01465	COG1175	transmembrane transport
N596_RS01470	COG0395	ABC-type sugar transport system, permease component
N596_RS01475	COG0366	Alpha amylase catalytic
N596_RS01480	COG1472	Belongs to the glycosyl hydrolase 3 family
N596_RS01495	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N596_RS01515	COG0366	Alpha amylase catalytic
N596_RS01525	COG1174	glycine betaine transport
N596_RS01540	COG1230	cation diffusion facilitator family transporter
N596_RS01550	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
N596_RS01565	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N596_RS01570	COG0569	domain protein
N596_RS01580	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
N596_RS01585	COG1074	ATP-dependent DNA helicase activity
N596_RS01605	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N596_RS01620	COG0300	oxidoreductase activity
N596_RS01625	COG2226	methyltransferase
N596_RS01635	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
N596_RS01635	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
N596_RS01640	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N596_RS01645	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
N596_RS01655	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N596_RS01660	COG0625	glutathione transferase activity
N596_RS01665	COG2384	SAM-dependent methyltransferase
N596_RS01670	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
N596_RS01675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N596_RS01685	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
N596_RS01695	COG1088	dTDP-glucose 4,6-dehydratase activity
N596_RS01710	COG1104	cysteine desulfurase activity
N596_RS01730	COG0211	Belongs to the bacterial ribosomal protein bL27 family
N596_RS01735	COG0583	DNA-binding transcription factor activity
N596_RS01745	COG0564	pseudouridine synthase activity
N596_RS01750	COG0488	(ABC) transporter
N596_RS01755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N596_RS01770	COG0647	UMP catabolic process
N596_RS01815	COG1573	uracil-dna glycosylase
N596_RS01820	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
N596_RS01825	COG0425	Belongs to the sulfur carrier protein TusA family
N596_RS01825	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N596_RS01860	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
N596_RS01865	COG0716	FMN binding
N596_RS01875	COG0038	chloride channel
N596_RS01880	COG0335	large ribosomal subunit rRNA binding
N596_RS01895	COG1518	maintenance of DNA repeat elements
N596_RS01920	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
N596_RS01925	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
N596_RS01930	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
N596_RS01940	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
N596_RS01950	COG0813	purine-nucleoside phosphorylase activity
N596_RS01965	COG0583	DNA-binding transcription factor activity
N596_RS01975	COG0543	2 iron, 2 sulfur cluster binding
N596_RS01980	COG0167	dihydroorotate dehydrogenase activity
N596_RS01985	COG0284	orotidine-5'-phosphate decarboxylase activity
N596_RS02010	COG1051	belongs to the nudix hydrolase family
N596_RS02015	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N596_RS02035	COG0473	3-isopropylmalate dehydrogenase activity
N596_RS02050	COG0066	3-isopropylmalate dehydratase activity
N596_RS02060	COG2323	membrane
N596_RS02070	COG4221	oxidoreductase activity
N596_RS02095	COG0187	DNA topoisomerase II activity
N596_RS02100	COG3339	Conserved Protein
N596_RS02110	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N596_RS02115	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N596_RS02135	COG0539	negative regulation of cytoplasmic translation
N596_RS02145	COG0039	L-malate dehydrogenase activity
N596_RS02150	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N596_RS02155	COG3764	Sortase (surface protein transpeptidase)
N596_RS02165	COG2003	Belongs to the UPF0758 family
N596_RS02185	COG1104	cysteine desulfurase activity
N596_RS02190	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N596_RS02200	COG2357	RelA SpoT domain protein
N596_RS02210	COG0564	pseudouridine synthase activity
N596_RS02215	COG0280	phosphate acetyltransferase
N596_RS02220	COG1194	a g-specific adenine glycosylase
N596_RS02230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N596_RS02235	COG4684	Psort location CytoplasmicMembrane, score
N596_RS02240	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
N596_RS02250	COG2759	Belongs to the formate--tetrahydrofolate ligase family
N596_RS02280	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N596_RS02285	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N596_RS02305	COG1940	carbohydrate kinase activity
N596_RS02310	COG0758	DNA mediated transformation
N596_RS02315	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N596_RS02350	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
N596_RS02355	COG0022	dehydrogenase e1 component
N596_RS02360	COG0508	dehydrogenase complex catalyzes the overall conversion of
N596_RS02370	COG0095	Lipoate-protein ligase
N596_RS02385	COG3458	cephalosporin-C deacetylase activity
N596_RS02395	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N596_RS02410	COG2188	Transcriptional regulator
N596_RS02430	COG0741	lytic transglycosylase activity
N596_RS02445	COG0456	acetyltransferase
N596_RS02455	COG2890	protein-(glutamine-N5) methyltransferase activity
N596_RS02460	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
N596_RS02470	COG1435	thymidine kinase activity
N596_RS02475	COG1942	4-Oxalocrotonate Tautomerase
N596_RS02480	COG0534	Mate efflux family protein
N596_RS02485	COG2233	PERMEase
N596_RS02505	COG0110	maltose O-acetyltransferase activity
N596_RS02510	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N596_RS02515	COG0805	protein transport
N596_RS02520	COG0672	)-iron permease
N596_RS02525	COG2837	iron assimilation
N596_RS02530	COG2822	iron ion transport
N596_RS02555	COG0431	NADPH-dependent FMN reductase
N596_RS02555	COG1053	succinate dehydrogenase
N596_RS02555	COG3976	FMN-binding domain protein
N596_RS02560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N596_RS02565	COG0785	Cytochrome C biogenesis protein
N596_RS02580	COG1132	(ABC) transporter
N596_RS02600	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
N596_RS02610	COG1388	LysM domain
N596_RS02610	COG1705	Flagellar rod assembly protein muramidase FlgJ
N596_RS02615	COG0218	Necessary for normal cell division and for the maintenance of normal septation
N596_RS02630	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
N596_RS02645	COG1940	carbohydrate kinase activity
N596_RS02655	COG0488	(ABC) transporter
N596_RS02660	COG0617	tRNA 3'-terminal CCA addition
N596_RS02665	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
N596_RS02670	COG1307	EDD domain protein, DegV family
N596_RS02680	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N596_RS02680	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N596_RS02680	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N596_RS02685	COG1105	Belongs to the carbohydrate kinase PfkB family
N596_RS02720	COG1837	Belongs to the UPF0109 family
N596_RS02735	COG1011	Hydrolase
N596_RS02760	COG0561	phosphatase activity
N596_RS02765	COG2195	Cleaves the N-terminal amino acid of tripeptides
N596_RS02770	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
N596_RS02775	COG0505	Belongs to the CarA family
N596_RS02780	COG0540	Belongs to the ATCase OTCase family
N596_RS02785	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
N596_RS02795	COG2824	Alkylphosphonate utilization operon protein PhnA
N596_RS02810	COG1051	belongs to the nudix hydrolase family
N596_RS02830	COG1051	belongs to the nudix hydrolase family
N596_RS02875	COG1131	(ABC) transporter
N596_RS02895	COG0765	amino acid transport
N596_RS02900	COG1126	abc transporter atp-binding protein
N596_RS02910	COG1132	(ABC) transporter
N596_RS02925	COG0017	Asparaginyl-tRNA synthetase
N596_RS02935	COG0436	Aminotransferase
N596_RS02940	COG1846	Transcriptional regulator
N596_RS02955	COG1272	protein, Hemolysin III
N596_RS02960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N596_RS02980	COG3142	Participates in the control of copper homeostasis
N596_RS02995	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N596_RS03000	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
N596_RS03005	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N596_RS03110	COG0135	phosphoribosylanthranilate isomerase activity
N596_RS03135	COG1396	sequence-specific DNA binding
N596_RS03145	COG1131	(ABC) transporter
N596_RS03160	COG0535	radical SAM domain protein
N596_RS03170	COG1396	sequence-specific DNA binding
N596_RS03180	COG0577	efflux transmembrane transporter activity
N596_RS03180	COG1136	(ABC) transporter
N596_RS03200	COG3843	relaxase mobilization nuclease domain protein
N596_RS03235	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N596_RS03245	COG0542	response to heat
N596_RS03375	COG0270	DNA (cytosine-5-)-methyltransferase activity
N596_RS03385	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N596_RS03395	COG0077	Prephenate dehydratase
N596_RS03400	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
N596_RS03405	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
N596_RS03410	COG3679	Belongs to the UPF0342 family
N596_RS03415	COG0287	Prephenate dehydrogenase
N596_RS03420	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
N596_RS03425	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
N596_RS03430	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N596_RS03435	COG0710	3-dehydroquinate dehydratase activity
N596_RS03440	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
N596_RS03445	COG1368	sulfuric ester hydrolase activity
N596_RS03450	COG1523	belongs to the glycosyl hydrolase 13 family
N596_RS03455	COG1597	lipid kinase activity
N596_RS03460	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N596_RS03465	COG4708	membrane
N596_RS03470	COG2246	polysaccharide biosynthetic process
N596_RS03475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N596_RS03475	COG0072	phenylalanine-tRNA ligase activity
N596_RS03480	COG1846	Transcriptional regulator
N596_RS03490	COG0024	Methionine aminopeptidase
N596_RS03495	COG4109	DRTGG domain
N596_RS03500	COG0519	Catalyzes the synthesis of GMP from XMP
N596_RS03505	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N596_RS03515	COG2217	Heavy metal translocating P-type atpase
N596_RS03550	COG2131	deaminase
N596_RS03560	COG0291	Belongs to the bacterial ribosomal protein bL35 family
N596_RS03570	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
N596_RS03585	COG1368	sulfuric ester hydrolase activity
N596_RS03615	COG1215	transferase activity, transferring glycosyl groups
N596_RS03625	COG1091	dTDP-4-dehydrorhamnose reductase activity
N596_RS03630	COG0463	Glycosyl transferase, family 2
N596_RS03635	COG1442	glycosyl transferase family 8
N596_RS03635	COG1216	Glycosyl transferase, family 2
N596_RS03670	COG1177	transmembrane transport
N596_RS03675	COG1175	transmembrane transport
N596_RS03680	COG3842	ATPase activity
N596_RS03685	COG0812	UDP-N-acetylmuramate dehydrogenase activity
N596_RS03700	COG0460	homoserine dehydrogenase
N596_RS03705	COG0726	polysaccharide deacetylase
N596_RS03710	COG1079	Belongs to the binding-protein-dependent transport system permease family
N596_RS03715	COG4603	Belongs to the binding-protein-dependent transport system permease family
N596_RS03720	COG3845	ABC transporter
N596_RS03725	COG1744	ABC transporter substrate-binding protein PnrA-like
N596_RS03735	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
N596_RS03745	COG2813	Specifically methylates the guanine in position
N596_RS03750	COG1072	(Pantothenic acid kinase))
N596_RS03755	COG0268	Binds directly to 16S ribosomal RNA
N596_RS03780	COG1131	(ABC) transporter
N596_RS03790	COG2936	dipeptidyl-peptidase activity
N596_RS03800	COG3118	belongs to the thioredoxin family
N596_RS03810	COG4166	transmembrane transport
N596_RS03815	COG0159	tryptophan synthase activity
N596_RS03825	COG0135	phosphoribosylanthranilate isomerase activity
N596_RS03840	COG0512	Glutamine amidotransferase of anthranilate synthase
N596_RS03845	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N596_RS03850	COG1363	Peptidase, m42
N596_RS03870	COG2514	catechol 2,3-dioxygenase activity
N596_RS03895	COG0732	type I restriction modification DNA specificity domain
N596_RS03905	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
N596_RS03920	COG1132	(ABC) transporter
N596_RS03925	COG1132	(ABC) transporter
N596_RS03950	COG4989	oxidoreductase activity
N596_RS03955	COG1668	transmembrane transport
N596_RS03960	COG4152	abc transporter atp-binding protein
N596_RS03970	COG1476	TRANSCRIPTIONal
N596_RS03980	COG0072	phenylalanine-tRNA ligase activity
N596_RS03980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N596_RS04000	COG1293	RNA-binding protein homologous to eukaryotic snRNP
N596_RS04005	COG3527	Alpha-acetolactate decarboxylase
N596_RS04015	COG0628	permease
N596_RS04020	COG2706	6-phosphogluconolactonase activity
N596_RS04045	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
N596_RS04050	COG0187	DNA topoisomerase II activity
N596_RS04065	COG0772	Belongs to the SEDS family
N596_RS04075	COG1199	ATP-dependent helicase activity
N596_RS04075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N596_RS04085	COG2177	Part of the ABC transporter FtsEX involved in
N596_RS04090	COG2884	Cell division ATP-binding protein ftsE
N596_RS04095	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
N596_RS04105	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N596_RS04120	COG1078	dGTPase activity
N596_RS04130	COG2348	transferase activity, transferring amino-acyl groups
N596_RS04145	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N596_RS04150	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
N596_RS04155	COG0772	Belongs to the SEDS family
N596_RS04165	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
N596_RS04175	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
N596_RS04180	COG0577	efflux transmembrane transporter activity
N596_RS04185	COG1136	(ABC) transporter
N596_RS04195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N596_RS04200	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
N596_RS04205	COG4443	Transcriptional Coactivator p15 (PC4)
N596_RS04215	COG0826	peptidase U32
N596_RS04240	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
N596_RS04245	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
N596_RS04255	COG3091	SprT-like family
N596_RS04260	COG2183	response to ionizing radiation
N596_RS04265	COG0701	Predicted permease
N596_RS04270	COG3689	TIGRFAM TIGR03943 family protein
N596_RS04275	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
N596_RS04280	COG0552	protein localization to endoplasmic reticulum
N596_RS04285	COG0561	phosphatase activity
N596_RS04290	COG0561	phosphatase activity
N596_RS04295	COG1196	nuclear chromosome segregation
N596_RS04300	COG0571	ribonuclease III activity
N596_RS04305	COG2832	Protein of unknown function (DUF454)
N596_RS04310	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
N596_RS04315	COG5002	protein histidine kinase activity
N596_RS04320	COG0745	RESPONSE REGULATOR receiver
N596_RS04325	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
N596_RS04330	COG0438	transferase activity, transferring glycosyl groups
N596_RS04340	COG1609	Transcriptional regulator
N596_RS04345	COG0006	proline dipeptidase activity
N596_RS04380	COG0737	Belongs to the 5'-nucleotidase family
N596_RS04395	COG1346	cytolysis
N596_RS04400	COG1380	Effector of murein hydrolase LrgA
N596_RS04415	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
N596_RS04420	COG0557	exoribonuclease II activity
N596_RS04430	COG2814	Major facilitator Superfamily
N596_RS04435	COG0237	dephospho-CoA kinase activity
N596_RS04440	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N596_RS04445	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
N596_RS04450	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
N596_RS04460	COG1132	(ABC) transporter
N596_RS04465	COG1132	(ABC) transporter
N596_RS04480	COG0686	Belongs to the AlaDH PNT family
N596_RS04485	COG1702	phosphate starvation-inducible protein PhoH
N596_RS04495	COG2996	Protein conserved in bacteria
N596_RS04505	COG0528	UMP kinase activity
N596_RS04515	COG0081	regulation of translation
N596_RS04520	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
N596_RS04530	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
N596_RS04535	COG0346	lactoylglutathione lyase activity
N596_RS04540	COG0697	spore germination
N596_RS04540	COG1674	ftsk spoiiie
N596_RS04560	COG4555	ABC transporter
N596_RS04570	COG0488	(ABC) transporter
N596_RS04575	COG1393	Belongs to the ArsC family
N596_RS04580	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N596_RS04595	COG4467	Involved in initiation control of chromosome replication
N596_RS04600	COG0470	DNA polymerase III
N596_RS04605	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
N596_RS04610	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
N596_RS04615	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
N596_RS04615	COG0617	tRNA 3'-terminal CCA addition
N596_RS04615	COG0517	IMP dehydrogenase activity
N596_RS04635	COG0559	Belongs to the binding-protein-dependent transport system permease family
N596_RS04655	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
N596_RS04660	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
N596_RS04665	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
N596_RS04670	COG0626	cystathionine gamma-synthase activity
N596_RS04675	COG2244	polysaccharide biosynthetic process
N596_RS04680	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
N596_RS04700	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
N596_RS04710	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N596_RS04715	COG4120	Belongs to the binding-protein-dependent transport system permease family
N596_RS04735	COG1253	flavin adenine dinucleotide binding
N596_RS04740	COG3711	transcriptional antiterminator
N596_RS04745	COG0628	permease
N596_RS04750	COG1119	ATPase activity
N596_RS04765	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
N596_RS04770	COG1242	4 iron, 4 sulfur cluster binding
N596_RS04780	COG0671	phosphoesterase, PA-phosphatase related
N596_RS04785	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
N596_RS04795	COG0569	domain protein
N596_RS04800	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N596_RS04810	COG1187	pseudouridine synthase activity
N596_RS04815	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
N596_RS04820	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
N596_RS04825	COG4974	Belongs to the 'phage' integrase family
N596_RS04830	COG0517	IMP dehydrogenase activity
N596_RS04840	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N596_RS04845	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
N596_RS04870	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N596_RS04875	COG1254	Belongs to the acylphosphatase family
N596_RS04890	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
N596_RS04915	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N596_RS04935	COG1484	DNA-dependent DNA replication
N596_RS04945	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
N596_RS04955	COG2190	(PTS) system
N596_RS04955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N596_RS04955	COG1263	PTS System
N596_RS04960	COG2801	Transposase and inactivated derivatives
N596_RS04970	COG0745	RESPONSE REGULATOR receiver
N596_RS04975	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
N596_RS04980	COG2268	Band 7 protein
N596_RS05000	COG0501	Belongs to the peptidase M48B family
N596_RS05005	COG1704	LemA family
N596_RS05010	COG0357	Ribosomal RNA small subunit methyltransferase G
N596_RS05015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N596_RS05020	COG4221	oxidoreductase activity
N596_RS05030	COG1122	ATPase activity
N596_RS05100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N596_RS05105	COG1473	amidohydrolase
N596_RS05110	COG0217	transcriptional regulatory protein
N596_RS05120	COG2226	methyltransferase
N596_RS05125	COG0799	negative regulation of ribosome biogenesis
N596_RS05130	COG1713	HD superfamily hydrolase involved in NAD metabolism
N596_RS05135	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
N596_RS05140	COG1534	Rna-binding protein
N596_RS05145	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
N596_RS05150	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
N596_RS05165	COG1523	belongs to the glycosyl hydrolase 13 family
N596_RS05170	COG1063	alcohol dehydrogenase
N596_RS05190	COG1335	isochorismatase
N596_RS05195	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
N596_RS05200	COG0436	Aminotransferase
N596_RS05205	COG0589	response to stress
N596_RS05210	COG0561	phosphatase activity
N596_RS05215	COG0252	asparaginase activity
N596_RS05220	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
N596_RS05230	COG0736	holo-[acyl-carrier-protein] synthase activity
N596_RS05235	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N596_RS05240	COG0653	protein targeting
N596_RS05245	COG1482	cell wall glycoprotein biosynthetic process
N596_RS05250	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
N596_RS05260	COG0242	peptide deformylase activity
N596_RS05265	COG1940	carbohydrate kinase activity
N596_RS05270	COG1263	PTS System
N596_RS05270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N596_RS05270	COG2190	(PTS) system
N596_RS05275	COG1621	beta-fructofuranosidase activity
N596_RS05280	COG1609	Transcriptional regulator
N596_RS05300	COG0006	proline dipeptidase activity
N596_RS05305	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N596_RS05325	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
N596_RS05330	COG0629	single-stranded DNA binding
N596_RS05335	COG0360	Binds together with S18 to 16S ribosomal RNA
N596_RS05355	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
N596_RS05365	COG1228	amidohydrolase
N596_RS05370	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
N596_RS05380	COG3404	Formiminotransferase-cyclodeaminase
N596_RS05395	COG0531	amino acid
N596_RS05400	COG2986	histidine ammonia-lyase
N596_RS05420	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
N596_RS05435	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N596_RS05455	COG2205	protein histidine kinase activity
N596_RS05460	COG0745	RESPONSE REGULATOR receiver
N596_RS05470	COG2723	6-phospho-beta-galactosidase activity
N596_RS05480	COG0028	Belongs to the TPP enzyme family
N596_RS05490	COG0561	phosphatase activity
N596_RS05495	COG2207	Transcriptional regulator
N596_RS05500	COG2207	Transcriptional regulator
N596_RS05510	COG2801	Transposase and inactivated derivatives
N596_RS05515	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
N596_RS05520	COG2843	Capsule synthesis protein
N596_RS05525	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N596_RS05525	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N596_RS05535	COG0167	dihydroorotate dehydrogenase activity
N596_RS05540	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
N596_RS05545	COG0484	heat shock protein binding
N596_RS05560	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
N596_RS05575	COG0588	phosphoglycerate mutase activity
N596_RS05580	COG0588	phosphoglycerate mutase activity
N596_RS05590	COG3830	Belongs to the UPF0237 family
N596_RS05605	COG3237	CsbD-like
N596_RS05615	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N596_RS05640	COG2217	Heavy metal translocating P-type atpase
N596_RS05650	COG3328	transposase activity
N596_RS05655	COG1597	lipid kinase activity
N596_RS05670	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N596_RS05675	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
N596_RS05685	COG3688	RNA-binding protein containing a PIN domain
N596_RS05705	COG0366	Alpha amylase catalytic
N596_RS05710	COG3842	ATPase activity
N596_RS05720	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
N596_RS05725	COG0215	cysteine-tRNA ligase activity
N596_RS05740	COG1045	serine acetyltransferase
N596_RS05755	COG1164	Oligoendopeptidase f
N596_RS05770	COG3118	belongs to the thioredoxin family
N596_RS05780	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
N596_RS05790	COG1187	pseudouridine synthase activity
N596_RS05800	COG0668	transmembrane transport
N596_RS05805	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
N596_RS05815	COG1193	negative regulation of DNA recombination
N596_RS05830	COG0386	Belongs to the glutathione peroxidase family
N596_RS05840	COG0681	Belongs to the peptidase S26 family
N596_RS05845	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N596_RS05850	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N596_RS05855	COG1882	Formate acetyltransferase
N596_RS05875	COG3425	synthase
N596_RS05900	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
N596_RS05930	COG2176	DNA-directed DNA polymerase activity
N596_RS05940	COG1914	H( )-stimulated, divalent metal cation uptake system
N596_RS05950	COG2081	HI0933 family
N596_RS05960	COG0789	Transcriptional regulator
N596_RS05965	COG0733	neurotransmitter:sodium symporter activity
N596_RS05985	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
N596_RS05995	COG1214	PFAM Peptidase M22, glycoprotease
N596_RS06000	COG5503	Protein of unknown function (DUF1447)
N596_RS06010	COG0174	glutamine synthetase
N596_RS06015	COG0789	Transcriptional regulator
N596_RS06025	COG0126	phosphoglycerate kinase activity
N596_RS06030	COG0366	Alpha amylase catalytic
N596_RS06060	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N596_RS06065	COG3481	metal-dependent phosphohydrolase, HD sub domain
N596_RS06075	COG1564	THIamine pyrophosphokinase
N596_RS06085	COG1162	GTPase activity
N596_RS06120	COG0084	hydrolase, TatD family'
N596_RS06125	COG0230	Belongs to the bacterial ribosomal protein bL34 family
N596_RS06135	COG1847	R3H domain protein
N596_RS06140	COG0706	membrane insertase activity
N596_RS06145	COG0594	ribonuclease P activity
N596_RS06240	COG1129	ABC transporter
N596_RS06260	COG0463	Glycosyl transferase, family 2
N596_RS06295	COG0756	dUTP diphosphatase activity
N596_RS06300	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
N596_RS06310	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
N596_RS06315	COG1210	Utp--glucose-1-phosphate uridylyltransferase
N596_RS06330	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N596_RS06335	COG1473	amidohydrolase
N596_RS06375	COG0166	Belongs to the GPI family
N596_RS06385	COG3732	PTS system glucitol sorbitol-specific
N596_RS06390	COG3730	PTS system glucitol sorbitol-specific
N596_RS06410	COG0166	Belongs to the GPI family
N596_RS06420	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
N596_RS06425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
N596_RS06430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N596_RS06440	COG3201	nicotinamide mononucleotide transporter
N596_RS06445	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
N596_RS06465	COG0542	response to heat
N596_RS06470	COG4463	regulation of RNA biosynthetic process
N596_RS06480	COG3250	beta-galactosidase activity
N596_RS06490	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
N596_RS06520	COG2321	neutral zinc metallopeptidase
N596_RS06525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N596_RS06530	COG0564	pseudouridine synthase activity
N596_RS06540	COG0803	Belongs to the bacterial solute-binding protein 9 family
N596_RS06560	COG0438	transferase activity, transferring glycosyl groups
N596_RS06565	COG0562	UDP-galactopyranose mutase
N596_RS06580	COG1063	alcohol dehydrogenase
N596_RS06585	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
N596_RS06590	COG1215	transferase activity, transferring glycosyl groups
N596_RS06595	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
N596_RS06600	COG0438	transferase activity, transferring glycosyl groups
N596_RS06605	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
N596_RS06610	COG3475	LICD family
N596_RS06620	COG0489	protein tyrosine kinase activity
N596_RS06625	COG3944	biosynthesis protein
N596_RS06630	COG4464	protein tyrosine phosphatase activity
N596_RS06635	COG1316	TRANSCRIPTIONal
N596_RS06650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N596_RS06660	COG0285	dihydrofolate synthase activity
N596_RS06665	COG3906	Belongs to the UPF0473 family
N596_RS06670	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
N596_RS06675	COG4472	Bacterial protein of unknown function (DUF965)
N596_RS06690	COG1393	Belongs to the ArsC family
N596_RS06700	COG1058	Belongs to the CinA family
N596_RS06700	COG1546	Belongs to the CinA family
N596_RS06705	COG0519	Catalyzes the synthesis of GMP from XMP
N596_RS06715	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
N596_RS06730	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
N596_RS06735	COG1438	arginine binding
N596_RS06740	COG0018	arginyl-trna synthetase
N596_RS06750	COG1780	Probably involved in ribonucleotide reductase function
N596_RS06760	COG0058	SHG alpha-glucan phosphorylase activity
N596_RS06765	COG1640	4-alpha-glucanotransferase
N596_RS06775	COG2182	Extracellular solute-binding protein
N596_RS06780	COG1175	transmembrane transport
N596_RS06785	COG3833	ABC-type maltose transport systems, permease component
N596_RS06790	COG5521	maltodextrose utilization protein MalA
N596_RS06795	COG1609	Transcriptional regulator
N596_RS06800	COG1523	belongs to the glycosyl hydrolase 13 family
N596_RS06805	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
N596_RS06820	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
N596_RS06825	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N596_RS06830	COG1696	Membrane protein involved in D-alanine export
N596_RS06855	COG1511	domain protein
N596_RS06865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N596_RS06870	COG2274	protein secretion by the type I secretion system
N596_RS06875	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
N596_RS06885	COG0305	Participates in initiation and elongation during chromosome replication
N596_RS06890	COG0359	binds to the 23S rRNA
N596_RS06900	COG0445	tRNA wobble uridine modification
N596_RS06905	COG0494	nUDIX hydrolase
N596_RS06920	COG1760	l-serine dehydratase
N596_RS06925	COG1760	l-serine dehydratase
N596_RS06930	COG0546	phosphoglycolate phosphatase activity
N596_RS06940	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
N596_RS06945	COG1122	ATPase activity
N596_RS06950	COG1122	ATPase activity
N596_RS06955	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N596_RS06960	COG0612	Peptidase, M16
N596_RS06970	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
N596_RS06975	COG0517	IMP dehydrogenase activity
N596_RS06975	COG0516	GMP reductase activity
N596_RS06985	COG0488	(ABC) transporter
N596_RS07020	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
N596_RS07025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N596_RS07030	COG1475	DNA binding
N596_RS07040	COG0592	DNA-directed DNA polymerase activity
N596_RS07055	COG0012	GTP binding
N596_RS07060	COG0193	aminoacyl-tRNA hydrolase activity
N596_RS07065	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
N596_RS07070	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
N596_RS07085	COG0037	tRNA processing
N596_RS07090	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
N596_RS07095	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N596_RS07235	COG3942	CHAP domain
N596_RS07240	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N596_RS07260	COG0436	Aminotransferase
N596_RS07265	COG1381	Involved in DNA repair and RecF pathway recombination
N596_RS07275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N596_RS07285	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N596_RS07295	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
N596_RS07300	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
N596_RS07335	COG3942	CHAP domain
N596_RS07340	COG0151	Belongs to the GarS family
N596_RS07345	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
N596_RS07370	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N596_RS07375	COG2188	Transcriptional regulator
N596_RS07385	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N596_RS07390	COG3715	PTS system
N596_RS07395	COG3716	PTS system mannose fructose sorbose family IID component
N596_RS07405	COG2222	sugar isomerase
N596_RS07415	COG2255	four-way junction helicase activity
N596_RS07425	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N596_RS07435	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
N596_RS07435	COG2755	lipolytic protein G-D-S-L family
N596_RS07440	COG1012	belongs to the aldehyde dehydrogenase family
N596_RS07440	COG1454	alcohol dehydrogenase
N596_RS07445	COG1063	alcohol dehydrogenase
N596_RS07470	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
N596_RS07480	COG1175	transmembrane transport
N596_RS07485	COG0395	ABC-type sugar transport system, permease component
N596_RS07490	COG2731	YhcH YjgK YiaL family protein
N596_RS07500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N596_RS07520	COG1269	ATP hydrolysis coupled proton transport
N596_RS07525	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N596_RS07535	COG1527	subunit (C
N596_RS07550	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
N596_RS07555	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
N596_RS07560	COG1394	ATPase activity, coupled to movement of substances
N596_RS07570	COG2807	transmembrane transport
N596_RS07575	COG2151	metal-sulfur cluster biosynthetic enzyme
N596_RS07600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
N596_RS07610	COG2184	nucleotidyltransferase activity
N596_RS07625	COG4932	domain protein
N596_RS07625	COG1388	LysM domain
N596_RS07645	COG1328	CTP reductase activity
N596_RS07665	COG0534	Mate efflux family protein
N596_RS07670	COG0546	phosphoglycolate phosphatase activity
N596_RS07680	COG3759	membrane
N596_RS07685	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N596_RS07685	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N596_RS07690	COG1832	CoA-binding protein
N596_RS07715	COG0088	Forms part of the polypeptide exit tunnel
N596_RS07730	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N596_RS07740	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
N596_RS07750	COG0255	Belongs to the universal ribosomal protein uL29 family
N596_RS07755	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
N596_RS07760	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
N596_RS07765	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
N596_RS07770	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
N596_RS07775	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
N596_RS07795	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
N596_RS07800	COG1841	ribosomal large subunit assembly
N596_RS07810	COG0201	protein transport
N596_RS07820	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
N596_RS07825	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N596_RS07830	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
N596_RS07835	COG0202	RNA polymerase activity
N596_RS07850	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N596_RS07850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N596_RS07855	COG3655	Transcriptional regulator
N596_RS07870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N596_RS07945	COG0582	viral genome integration into host DNA
N596_RS07980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N596_RS07985	COG1846	Transcriptional regulator
N596_RS07990	COG1121	(ABC) transporter
N596_RS07995	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N596_RS08000	COG0803	Belongs to the bacterial solute-binding protein 9 family
N596_RS08000	COG3443	Belongs to the bacterial solute-binding protein 9 family
N596_RS08020	COG0383	alpha-mannosidase activity
N596_RS08035	COG4209	transmembrane transport
N596_RS08040	COG0395	ABC-type sugar transport system, permease component
N596_RS08045	COG1653	transport
N596_RS08055	COG2972	Histidine kinase
N596_RS08060	COG2207	Transcriptional regulator
N596_RS08060	COG4753	response regulator
N596_RS08065	COG2226	methyltransferase
N596_RS08075	COG4499	WXG100 protein secretion system (Wss), protein YukC
N596_RS08075	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N596_RS08080	COG0085	RNA polymerase activity
N596_RS08085	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N596_RS08090	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
N596_RS08100	COG1215	transferase activity, transferring glycosyl groups
N596_RS08105	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
N596_RS08115	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N596_RS08120	COG1459	type II secretion system
N596_RS08125	COG4537	Required for transformation and DNA binding
N596_RS08150	COG0827	DNA restriction-modification system
N596_RS08155	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N596_RS08160	COG1266	CAAX protease self-immunity
N596_RS08165	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
N596_RS08170	COG0285	dihydrofolate synthase activity
N596_RS08175	COG0302	gtp cyclohydrolase
N596_RS08180	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
N596_RS08180	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N596_RS08185	COG4868	Belongs to the UPF0371 family
N596_RS08190	COG1363	Peptidase, m42
N596_RS08200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N596_RS08205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N596_RS08215	COG1609	Transcriptional regulator
N596_RS08220	COG4585	Histidine kinase
N596_RS08225	COG2197	response regulator
N596_RS08250	COG3716	PTS system mannose fructose sorbose family IID component
N596_RS08275	COG1136	(ABC) transporter
N596_RS08285	COG0745	RESPONSE REGULATOR receiver
N596_RS08290	COG5002	protein histidine kinase activity
N596_RS08295	COG1136	(ABC) transporter
N596_RS08300	COG0577	efflux transmembrane transporter activity
N596_RS08340	COG0582	viral genome integration into host DNA
N596_RS08350	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N596_RS08370	COG1051	belongs to the nudix hydrolase family
N596_RS08380	COG2264	protein methyltransferase activity
N596_RS08385	COG1385	rRNA (uridine-N3-)-methyltransferase activity
N596_RS08390	COG0737	Belongs to the 5'-nucleotidase family
N596_RS08405	COG1490	D-aminoacyl-tRNA deacylase activity
N596_RS08440	COG3590	peptidase
N596_RS08450	COG1349	DNA-binding transcription factor activity
N596_RS08455	COG2390	Transcriptional regulator
N596_RS08460	COG1447	Phosphotransferase system cellobiose-specific component IIA
N596_RS08470	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N596_RS08475	COG1882	Formate acetyltransferase
N596_RS08495	COG4166	transmembrane transport
N596_RS08505	COG0789	Transcriptional regulator
N596_RS08525	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
N596_RS08530	COG2723	6-phospho-beta-galactosidase activity
N596_RS08550	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N596_RS08555	COG2213	PTS system mannitol-specific
N596_RS08560	COG3711	transcriptional antiterminator
N596_RS08565	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
N596_RS08580	COG0561	phosphatase activity
N596_RS08600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N596_RS08605	COG0765	amino acid transport
N596_RS08610	COG0765	amino acid transport
N596_RS08615	COG1126	abc transporter atp-binding protein
N596_RS08635	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N596_RS08640	COG4589	Belongs to the CDS family
N596_RS08655	COG2176	DNA-directed DNA polymerase activity
N596_RS08660	COG1396	sequence-specific DNA binding
N596_RS08675	COG3041	Addiction module toxin RelE StbE family
N596_RS08690	COG2309	aminopeptidase activity
N596_RS08695	COG3064	Membrane
N596_RS08695	COG3583	domain protein
N596_RS08695	COG3525	Glycosyl hydrolase, family 20, catalytic domain
N596_RS08705	COG0351	phosphomethylpyrimidine kinase
N596_RS08710	COG4720	Psort location CytoplasmicMembrane, score
N596_RS08715	COG4475	Protein of unknown function (DUF436)
N596_RS08720	COG0544	peptidyl-prolyl cis-trans isomerase activity
N596_RS08725	COG3343	RNA polymerase activity
N596_RS08740	COG0191	fructose-bisphosphate aldolase activity
N596_RS08745	COG1349	DNA-binding transcription factor activity
N596_RS08755	COG0698	ribose 5-phosphate isomerase
N596_RS08765	COG3684	Belongs to the aldolase LacD family
N596_RS08770	COG3711	transcriptional antiterminator
N596_RS08825	COG0227	Belongs to the bacterial ribosomal protein bL28 family
N596_RS08835	COG1461	Dihydroxyacetone kinase
N596_RS08855	COG1131	(ABC) transporter
N596_RS08860	COG0842	Transport permease protein
N596_RS08865	COG4585	Histidine kinase
N596_RS08870	COG2197	response regulator
N596_RS08875	COG0028	Belongs to the TPP enzyme family
N596_RS08880	COG0440	acetolactate synthase activity
N596_RS08885	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
N596_RS08890	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
N596_RS08905	COG1126	abc transporter atp-binding protein
N596_RS08910	COG0765	amino acid transport
N596_RS08920	COG1968	undecaprenyl-diphosphatase activity
N596_RS08925	COG4862	establishment of competence for transformation
N596_RS08930	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N596_RS08940	COG0719	Fe-S assembly protein
N596_RS08945	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N596_RS08955	COG0719	Fe-S assembly protein
N596_RS08965	COG1686	Belongs to the peptidase S11 family
N596_RS08970	COG4166	transmembrane transport
N596_RS08975	COG4166	transmembrane transport
N596_RS08980	COG0601	transmembrane transport
N596_RS08985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N596_RS08990	COG0444	Belongs to the ABC transporter superfamily
N596_RS08995	COG4608	Belongs to the ABC transporter superfamily
N596_RS09000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N596_RS09000	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N596_RS09005	COG3655	Transcriptional regulator
N596_RS09020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N596_RS09040	COG0527	aspartate kinase activity
N596_RS09045	COG1024	Enoyl-CoA hydratase
N596_RS09065	COG2070	2-Nitropropane dioxygenase
N596_RS09070	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
N596_RS09075	COG1028	Short-chain dehydrogenase reductase Sdr
N596_RS09080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N596_RS09095	COG0439	Biotin carboxylase
N596_RS09100	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
N596_RS09105	COG0825	malonyl-CoA metabolic process
N596_RS09120	COG3716	PTS system mannose fructose sorbose family IID component
N596_RS09125	COG3715	PTS system
N596_RS09135	COG0561	phosphatase activity
N596_RS09140	COG2252	PERMEase
N596_RS09145	COG0802	atpase or kinase
N596_RS09155	COG1316	TRANSCRIPTIONal
N596_RS09165	COG0537	adenosine 5'-monophosphoramidase activity
N596_RS09170	COG1131	(ABC) transporter
N596_RS09185	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N596_RS09190	COG0779	Required for maturation of 30S ribosomal subunits
N596_RS09195	COG0195	Participates in both transcription termination and antitermination
N596_RS09200	COG2740	Nucleic-acid-binding protein implicated in transcription termination
N596_RS09215	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
N596_RS09220	COG1283	sodium-dependent phosphate transmembrane transporter activity
N596_RS09235	COG0656	L-ascorbic acid biosynthetic process
N596_RS09275	COG0768	penicillin binding
N596_RS09280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N596_RS09285	COG0513	Belongs to the DEAD box helicase family
N596_RS09290	COG0765	amino acid transport
N596_RS09295	COG1126	abc transporter atp-binding protein
N596_RS09305	COG0492	ferredoxin-NADP+ reductase activity
N596_RS09310	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
N596_RS09320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N596_RS09325	COG3579	cysteine-type endopeptidase activity
N596_RS09330	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N596_RS09335	COG3331	DNA recombination
N596_RS09340	COG4474	Belongs to the UPF0398 family
N596_RS09350	COG0116	Belongs to the methyltransferase superfamily
N596_RS09360	COG1854	S-ribosylhomocysteine lyase activity
N596_RS09365	COG1418	mRNA catabolic process
N596_RS09370	COG0194	GDP metabolic process
N596_RS09375	COG1758	RNA polymerase activity
N596_RS09380	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
N596_RS09385	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
N596_RS09390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N596_RS09390	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N596_RS09395	COG0631	protein serine/threonine phosphatase activity
N596_RS09400	COG0515	serine threonine protein kinase
N596_RS09400	COG2815	serine threonine protein kinase
N596_RS09410	COG4585	Histidine kinase
N596_RS09415	COG2197	response regulator
N596_RS09425	COG1185	polyribonucleotide nucleotidyltransferase activity
N596_RS09435	COG1739	Uncharacterized protein family UPF0029
N596_RS09440	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
N596_RS09445	COG1040	competence protein
N596_RS09485	COG3290	protein histidine kinase activity
N596_RS09490	COG3064	Membrane
N596_RS09490	COG3525	Glycosyl hydrolase, family 20, catalytic domain
N596_RS09490	COG3583	domain protein