locus-tag	class	description
N597_RS00065	COG0582	viral genome integration into host DNA
N597_RS00105	COG1846	Transcriptional regulator
N597_RS00110	COG1121	(ABC) transporter
N597_RS00115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N597_RS00120	COG0803	Belongs to the bacterial solute-binding protein 9 family
N597_RS00120	COG3443	Belongs to the bacterial solute-binding protein 9 family
N597_RS00140	COG0383	alpha-mannosidase activity
N597_RS00155	COG4209	transmembrane transport
N597_RS00160	COG0395	ABC-type sugar transport system, permease component
N597_RS00165	COG1653	transport
N597_RS00175	COG2972	Histidine kinase
N597_RS00180	COG4753	response regulator
N597_RS00180	COG2207	Transcriptional regulator
N597_RS00185	COG2226	methyltransferase
N597_RS00195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N597_RS00195	COG4499	WXG100 protein secretion system (Wss), protein YukC
N597_RS00200	COG0085	RNA polymerase activity
N597_RS00205	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N597_RS00210	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
N597_RS00220	COG1215	transferase activity, transferring glycosyl groups
N597_RS00225	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
N597_RS00235	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N597_RS00240	COG1459	type II secretion system
N597_RS00245	COG4537	Required for transformation and DNA binding
N597_RS00270	COG0827	DNA restriction-modification system
N597_RS00275	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N597_RS00280	COG1266	CAAX protease self-immunity
N597_RS00285	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
N597_RS00290	COG0285	dihydrofolate synthase activity
N597_RS00295	COG0302	gtp cyclohydrolase
N597_RS00300	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N597_RS00300	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
N597_RS00305	COG4868	Belongs to the UPF0371 family
N597_RS00310	COG1363	Peptidase, m42
N597_RS00320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N597_RS00325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N597_RS00335	COG1609	Transcriptional regulator
N597_RS00340	COG4585	Histidine kinase
N597_RS00345	COG2197	response regulator
N597_RS00370	COG3716	PTS system mannose fructose sorbose family IID component
N597_RS00395	COG1136	(ABC) transporter
N597_RS00405	COG0745	RESPONSE REGULATOR receiver
N597_RS00410	COG5002	protein histidine kinase activity
N597_RS00415	COG1136	(ABC) transporter
N597_RS00420	COG0577	efflux transmembrane transporter activity
N597_RS00460	COG0582	viral genome integration into host DNA
N597_RS00470	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N597_RS00495	COG2264	protein methyltransferase activity
N597_RS00500	COG1385	rRNA (uridine-N3-)-methyltransferase activity
N597_RS00505	COG0737	Belongs to the 5'-nucleotidase family
N597_RS00520	COG1490	D-aminoacyl-tRNA deacylase activity
N597_RS00555	COG3590	peptidase
N597_RS00565	COG1349	DNA-binding transcription factor activity
N597_RS00570	COG2390	Transcriptional regulator
N597_RS00575	COG1447	Phosphotransferase system cellobiose-specific component IIA
N597_RS00585	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N597_RS00590	COG1882	Formate acetyltransferase
N597_RS00610	COG4166	transmembrane transport
N597_RS00630	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
N597_RS00635	COG2723	6-phospho-beta-galactosidase activity
N597_RS00655	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N597_RS00660	COG2213	PTS system mannitol-specific
N597_RS00665	COG3711	transcriptional antiterminator
N597_RS00670	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
N597_RS00685	COG0561	phosphatase activity
N597_RS00705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N597_RS00710	COG0765	amino acid transport
N597_RS00715	COG0765	amino acid transport
N597_RS00720	COG1126	abc transporter atp-binding protein
N597_RS00740	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N597_RS00745	COG4589	Belongs to the CDS family
N597_RS00760	COG2176	DNA-directed DNA polymerase activity
N597_RS00765	COG1396	sequence-specific DNA binding
N597_RS00780	COG3041	Addiction module toxin RelE StbE family
N597_RS00795	COG2309	aminopeptidase activity
N597_RS00800	COG3064	Membrane
N597_RS00800	COG3583	domain protein
N597_RS00800	COG3525	Glycosyl hydrolase, family 20, catalytic domain
N597_RS00810	COG0351	phosphomethylpyrimidine kinase
N597_RS00815	COG4720	Psort location CytoplasmicMembrane, score
N597_RS00820	COG4475	Protein of unknown function (DUF436)
N597_RS00825	COG0544	peptidyl-prolyl cis-trans isomerase activity
N597_RS00830	COG3343	RNA polymerase activity
N597_RS00845	COG0191	fructose-bisphosphate aldolase activity
N597_RS00865	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N597_RS00925	COG0227	Belongs to the bacterial ribosomal protein bL28 family
N597_RS00935	COG1461	Dihydroxyacetone kinase
N597_RS00955	COG1131	(ABC) transporter
N597_RS00960	COG0842	Transport permease protein
N597_RS00965	COG4585	Histidine kinase
N597_RS00970	COG2197	response regulator
N597_RS00975	COG0519	Catalyzes the synthesis of GMP from XMP
N597_RS00985	COG0028	Belongs to the TPP enzyme family
N597_RS00990	COG0440	acetolactate synthase activity
N597_RS00995	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
N597_RS01000	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
N597_RS01015	COG1126	abc transporter atp-binding protein
N597_RS01020	COG0765	amino acid transport
N597_RS01030	COG1968	undecaprenyl-diphosphatase activity
N597_RS01035	COG4862	establishment of competence for transformation
N597_RS01040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N597_RS01050	COG0719	Fe-S assembly protein
N597_RS01055	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N597_RS01065	COG0719	Fe-S assembly protein
N597_RS01075	COG1686	Belongs to the peptidase S11 family
N597_RS01080	COG4166	transmembrane transport
N597_RS01085	COG4166	transmembrane transport
N597_RS01090	COG0601	transmembrane transport
N597_RS01095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N597_RS01100	COG0444	Belongs to the ABC transporter superfamily
N597_RS01105	COG4608	Belongs to the ABC transporter superfamily
N597_RS01210	COG0527	aspartate kinase activity
N597_RS01215	COG1024	Enoyl-CoA hydratase
N597_RS01240	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
N597_RS01245	COG1028	Short-chain dehydrogenase reductase Sdr
N597_RS01250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N597_RS01265	COG0439	Biotin carboxylase
N597_RS01270	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
N597_RS01275	COG0825	malonyl-CoA metabolic process
N597_RS01290	COG3716	PTS system mannose fructose sorbose family IID component
N597_RS01295	COG3715	PTS system
N597_RS01305	COG1064	alcohol dehydrogenase
N597_RS01310	COG0561	phosphatase activity
N597_RS01315	COG2252	PERMEase
N597_RS01320	COG0802	atpase or kinase
N597_RS01330	COG1316	TRANSCRIPTIONal
N597_RS01340	COG0537	adenosine 5'-monophosphoramidase activity
N597_RS01345	COG1131	(ABC) transporter
N597_RS01360	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N597_RS01365	COG0779	Required for maturation of 30S ribosomal subunits
N597_RS01370	COG0195	Participates in both transcription termination and antitermination
N597_RS01375	COG2740	Nucleic-acid-binding protein implicated in transcription termination
N597_RS01390	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
N597_RS01395	COG1283	sodium-dependent phosphate transmembrane transporter activity
N597_RS01410	COG0656	L-ascorbic acid biosynthetic process
N597_RS01450	COG0768	penicillin binding
N597_RS01455	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N597_RS01460	COG0513	Belongs to the DEAD box helicase family
N597_RS01465	COG0765	amino acid transport
N597_RS01470	COG1126	abc transporter atp-binding protein
N597_RS01480	COG0492	ferredoxin-NADP+ reductase activity
N597_RS01485	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
N597_RS01495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N597_RS01500	COG3579	cysteine-type endopeptidase activity
N597_RS01505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N597_RS01510	COG3331	DNA recombination
N597_RS01515	COG4474	Belongs to the UPF0398 family
N597_RS01525	COG0116	Belongs to the methyltransferase superfamily
N597_RS01535	COG1854	S-ribosylhomocysteine lyase activity
N597_RS01540	COG1418	mRNA catabolic process
N597_RS01545	COG0194	GDP metabolic process
N597_RS01550	COG1758	RNA polymerase activity
N597_RS01555	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
N597_RS01560	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
N597_RS01565	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N597_RS01565	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N597_RS01570	COG0631	protein serine/threonine phosphatase activity
N597_RS01575	COG0515	serine threonine protein kinase
N597_RS01575	COG2815	serine threonine protein kinase
N597_RS01585	COG4585	Histidine kinase
N597_RS01590	COG2197	response regulator
N597_RS01600	COG1185	polyribonucleotide nucleotidyltransferase activity
N597_RS01610	COG1739	Uncharacterized protein family UPF0029
N597_RS01615	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
N597_RS01620	COG1040	competence protein
N597_RS01710	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N597_RS01715	COG0295	cytidine deaminase activity
N597_RS01745	COG0519	Catalyzes the synthesis of GMP from XMP
N597_RS01760	COG0525	valine-tRNA ligase activity
N597_RS01790	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N597_RS01800	COG0742	ribosomal rna small subunit methyltransferase
N597_RS01805	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
N597_RS01810	COG3480	Lon protease (S16) C-terminal proteolytic domain
N597_RS01820	COG0785	Cytochrome C biogenesis protein
N597_RS01830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N597_RS01835	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N597_RS01835	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N597_RS01840	COG2207	Transcriptional regulator
N597_RS01840	COG4753	response regulator
N597_RS01845	COG2972	Histidine kinase
N597_RS01850	COG4470	Protein conserved in bacteria
N597_RS01855	COG0820	rRNA (adenine-C2-)-methyltransferase activity
N597_RS01865	COG0133	tryptophan synthase activity
N597_RS01895	COG1187	pseudouridine synthase activity
N597_RS01900	COG1217	gtp-binding protein TYPA
N597_RS01925	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
N597_RS01935	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
N597_RS01940	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
N597_RS01945	COG1799	cell septum assembly
N597_RS01960	COG3599	regulation of cell shape
N597_RS01965	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
N597_RS01980	COG0494	nUDIX hydrolase
N597_RS01985	COG0542	response to heat
N597_RS01990	COG4703	Protein of unknown function (DUF1797)
N597_RS01995	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
N597_RS02000	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
N597_RS02005	COG1570	exodeoxyribonuclease VII activity
N597_RS02010	COG1722	exodeoxyribonuclease VII activity
N597_RS02020	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
N597_RS02025	COG1438	arginine binding
N597_RS02030	COG0497	DNA recombination
N597_RS02035	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
N597_RS02040	COG1307	EDD domain protein, DegV family
N597_RS02055	COG0588	phosphoglycerate mutase activity
N597_RS02060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N597_RS02060	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N597_RS02065	COG3655	Transcriptional regulator
N597_RS02085	COG0745	RESPONSE REGULATOR receiver
N597_RS02095	COG1136	(ABC) transporter
N597_RS02100	COG0577	efflux transmembrane transporter activity
N597_RS02115	COG1136	(ABC) transporter
N597_RS02120	COG0577	efflux transmembrane transporter activity
N597_RS02125	COG4166	transmembrane transport
N597_RS02145	COG1028	Short-chain dehydrogenase reductase Sdr
N597_RS02290	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N597_RS02295	COG0494	nUDIX hydrolase
N597_RS02305	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
N597_RS02315	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
N597_RS02330	COG0708	Exodeoxyribonuclease III
N597_RS02335	COG0768	penicillin binding
N597_RS02340	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
N597_RS02350	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N597_RS02355	COG1051	belongs to the nudix hydrolase family
N597_RS02380	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
N597_RS02400	COG0513	Belongs to the DEAD box helicase family
N597_RS02405	COG1349	DNA-binding transcription factor activity
N597_RS02420	COG3775	system Galactitol-specific IIC component
N597_RS02435	COG0698	ribose 5-phosphate isomerase
N597_RS02440	COG1105	Belongs to the carbohydrate kinase PfkB family
N597_RS02445	COG3684	Belongs to the aldolase LacD family
N597_RS02460	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
N597_RS02465	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
N597_RS02470	COG0204	Acyl-transferase
N597_RS02475	COG1555	photosystem II stabilization
N597_RS02475	COG1596	polysaccharide export
N597_RS02480	COG2333	competence protein COMEC
N597_RS02480	COG0658	competence protein
N597_RS02490	COG1466	dna polymerase III delta subunit
N597_RS02495	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
N597_RS02500	COG0433	COG0433 Predicted ATPase
N597_RS02515	COG2235	arginine
N597_RS02520	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
N597_RS02525	COG0549	Belongs to the carbamate kinase family
N597_RS02530	COG1288	antiporter activity
N597_RS02535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N597_RS02545	COG2801	Transposase and inactivated derivatives
N597_RS02550	COG1438	arginine binding
N597_RS02555	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
N597_RS02575	COG1686	Belongs to the peptidase S11 family
N597_RS02605	COG4122	O-methyltransferase activity
N597_RS02610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N597_RS02620	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N597_RS02625	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N597_RS02630	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N597_RS02635	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N597_RS02650	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
N597_RS02660	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
N597_RS02665	COG0297	glycogen (starch) synthase activity
N597_RS02670	COG3064	Membrane
N597_RS02680	COG0356	it plays a direct role in the translocation of protons across the membrane
N597_RS02685	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
N597_RS02690	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N597_RS02695	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
N597_RS02700	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
N597_RS02710	COG0355	proton-transporting ATP synthase activity, rotational mechanism
N597_RS02720	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N597_RS02745	COG0488	(ABC) transporter
N597_RS02760	COG2814	Major facilitator Superfamily
N597_RS02775	COG3442	glutamine amidotransferase
N597_RS02780	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N597_RS02785	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
N597_RS02795	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N597_RS02800	COG4932	domain protein
N597_RS02805	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N597_RS02815	COG0251	oxidation-reduction process
N597_RS02820	COG1660	Displays ATPase and GTPase activities
N597_RS02825	COG0391	Required for morphogenesis under gluconeogenic growth conditions
N597_RS02835	COG0492	ferredoxin-NADP+ reductase activity
N597_RS02850	COG0828	Belongs to the bacterial ribosomal protein bS21 family
N597_RS02855	COG1970	mechanosensitive ion channel activity
N597_RS02860	COG0358	DNA primase activity
N597_RS02865	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N597_RS02870	COG2151	metal-sulfur cluster biosynthetic enzyme
N597_RS02875	COG1131	(ABC) transporter
N597_RS02900	COG0469	pyruvate kinase activity
N597_RS02905	COG0681	Belongs to the peptidase S26 family
N597_RS02910	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
N597_RS02915	COG0210	DNA helicase
N597_RS02935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N597_RS02940	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
N597_RS02945	COG0196	riboflavin kinase activity
N597_RS02950	COG1393	Belongs to the ArsC family
N597_RS02960	COG0483	inositol monophosphate 1-phosphatase activity
N597_RS02965	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N597_RS02965	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
N597_RS02970	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N597_RS02975	COG0573	inorganic phosphate transmembrane transporter activity
N597_RS02980	COG0581	inorganic phosphate transmembrane transporter activity
N597_RS02985	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N597_RS02990	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N597_RS02995	COG0704	Plays a role in the regulation of phosphate uptake
N597_RS03005	COG1268	BioY protein
N597_RS03015	COG0745	RESPONSE REGULATOR receiver
N597_RS03020	COG5002	protein histidine kinase activity
N597_RS03030	COG0726	polysaccharide deacetylase
N597_RS03040	COG0673	inositol 2-dehydrogenase activity
N597_RS03055	COG1956	GAF domain-containing protein
N597_RS03060	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
N597_RS03075	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
N597_RS03075	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
N597_RS03080	COG1609	Transcriptional regulator
N597_RS03085	COG2207	Transcriptional regulator
N597_RS03090	COG3345	alpha-galactosidase
N597_RS03095	COG1653	transport
N597_RS03100	COG1175	transmembrane transport
N597_RS03105	COG0395	ABC-type sugar transport system, permease component
N597_RS03110	COG0366	Alpha amylase catalytic
N597_RS03115	COG1472	Belongs to the glycosyl hydrolase 3 family
N597_RS03130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N597_RS03150	COG0366	Alpha amylase catalytic
N597_RS03160	COG1174	glycine betaine transport
N597_RS03175	COG1230	cation diffusion facilitator family transporter
N597_RS03185	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
N597_RS03200	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N597_RS03205	COG0569	domain protein
N597_RS03215	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
N597_RS03220	COG1074	ATP-dependent DNA helicase activity
N597_RS03240	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N597_RS03255	COG0300	oxidoreductase activity
N597_RS03260	COG2226	methyltransferase
N597_RS03275	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
N597_RS03275	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
N597_RS03280	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N597_RS03285	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
N597_RS03295	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N597_RS03300	COG0625	glutathione transferase activity
N597_RS03305	COG2384	SAM-dependent methyltransferase
N597_RS03310	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
N597_RS03315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N597_RS03325	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
N597_RS03335	COG1088	dTDP-glucose 4,6-dehydratase activity
N597_RS03350	COG1104	cysteine desulfurase activity
N597_RS03360	COG0574	Belongs to the PEP-utilizing enzyme family
N597_RS03360	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N597_RS03365	COG0517	IMP dehydrogenase activity
N597_RS03370	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
N597_RS03375	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
N597_RS03390	COG0211	Belongs to the bacterial ribosomal protein bL27 family
N597_RS03395	COG0583	DNA-binding transcription factor activity
N597_RS03400	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
N597_RS03405	COG0564	pseudouridine synthase activity
N597_RS03415	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
N597_RS03420	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
N597_RS03425	COG0488	(ABC) transporter
N597_RS03430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N597_RS03445	COG0647	UMP catabolic process
N597_RS03490	COG1573	uracil-dna glycosylase
N597_RS03495	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
N597_RS03500	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N597_RS03500	COG0425	Belongs to the sulfur carrier protein TusA family
N597_RS03525	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
N597_RS03530	COG0716	FMN binding
N597_RS03535	COG0077	Prephenate dehydratase
N597_RS03535	COG1605	Chorismate mutase
N597_RS03540	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N597_RS03545	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N597_RS03550	COG0335	large ribosomal subunit rRNA binding
N597_RS03570	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
N597_RS03575	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
N597_RS03580	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
N597_RS03590	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
N597_RS03600	COG0813	purine-nucleoside phosphorylase activity
N597_RS03615	COG0583	DNA-binding transcription factor activity
N597_RS03625	COG0543	2 iron, 2 sulfur cluster binding
N597_RS03630	COG0167	dihydroorotate dehydrogenase activity
N597_RS03635	COG0284	orotidine-5'-phosphate decarboxylase activity
N597_RS03660	COG1051	belongs to the nudix hydrolase family
N597_RS03665	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N597_RS03685	COG0473	3-isopropylmalate dehydrogenase activity
N597_RS03700	COG0066	3-isopropylmalate dehydratase activity
N597_RS03720	COG2323	membrane
N597_RS03730	COG1028	Short-chain dehydrogenase reductase Sdr
N597_RS03755	COG0187	DNA topoisomerase II activity
N597_RS03760	COG3339	Conserved Protein
N597_RS03770	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N597_RS03775	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N597_RS03795	COG0539	negative regulation of cytoplasmic translation
N597_RS03805	COG0039	L-malate dehydrogenase activity
N597_RS03810	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N597_RS03815	COG3764	Sortase (surface protein transpeptidase)
N597_RS03825	COG2003	Belongs to the UPF0758 family
N597_RS03845	COG1104	cysteine desulfurase activity
N597_RS03850	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N597_RS03860	COG2357	RelA SpoT domain protein
N597_RS03870	COG0564	pseudouridine synthase activity
N597_RS03875	COG0280	phosphate acetyltransferase
N597_RS03880	COG1194	a g-specific adenine glycosylase
N597_RS03890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N597_RS03895	COG4684	Psort location CytoplasmicMembrane, score
N597_RS03900	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
N597_RS03910	COG2759	Belongs to the formate--tetrahydrofolate ligase family
N597_RS03930	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N597_RS03935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N597_RS03955	COG1940	carbohydrate kinase activity
N597_RS03960	COG0758	DNA mediated transformation
N597_RS03965	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N597_RS04000	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
N597_RS04005	COG0022	dehydrogenase e1 component
N597_RS04010	COG0508	dehydrogenase complex catalyzes the overall conversion of
N597_RS04015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N597_RS04020	COG0095	Lipoate-protein ligase
N597_RS04035	COG3458	cephalosporin-C deacetylase activity
N597_RS04045	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N597_RS04060	COG2188	Transcriptional regulator
N597_RS04080	COG0464	growth
N597_RS04140	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
N597_RS04155	COG0741	lytic transglycosylase activity
N597_RS04170	COG0456	acetyltransferase
N597_RS04180	COG2890	protein-(glutamine-N5) methyltransferase activity
N597_RS04185	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
N597_RS04190	COG1435	thymidine kinase activity
N597_RS04195	COG1942	4-Oxalocrotonate Tautomerase
N597_RS04200	COG0534	Mate efflux family protein
N597_RS04205	COG2233	PERMEase
N597_RS04225	COG0110	maltose O-acetyltransferase activity
N597_RS04235	COG0805	protein transport
N597_RS04240	COG0672	)-iron permease
N597_RS04245	COG2837	iron assimilation
N597_RS04250	COG2822	iron ion transport
N597_RS04255	COG0038	chloride channel
N597_RS04280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N597_RS04285	COG0785	Cytochrome C biogenesis protein
N597_RS04300	COG1132	(ABC) transporter
N597_RS04320	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
N597_RS04330	COG1388	LysM domain
N597_RS04330	COG1705	Flagellar rod assembly protein muramidase FlgJ
N597_RS04335	COG0218	Necessary for normal cell division and for the maintenance of normal septation
N597_RS04350	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
N597_RS04365	COG1940	carbohydrate kinase activity
N597_RS04375	COG2801	Transposase and inactivated derivatives
N597_RS04385	COG0488	(ABC) transporter
N597_RS04390	COG0617	tRNA 3'-terminal CCA addition
N597_RS04395	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
N597_RS04400	COG1307	EDD domain protein, DegV family
N597_RS04410	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N597_RS04410	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N597_RS04410	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N597_RS04415	COG1105	Belongs to the carbohydrate kinase PfkB family
N597_RS04420	COG1349	DNA-binding transcription factor activity
N597_RS04450	COG1837	Belongs to the UPF0109 family
N597_RS04465	COG1011	Hydrolase
N597_RS04495	COG0561	phosphatase activity
N597_RS04500	COG2195	Cleaves the N-terminal amino acid of tripeptides
N597_RS04505	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
N597_RS04510	COG0505	Belongs to the CarA family
N597_RS04515	COG0540	Belongs to the ATCase OTCase family
N597_RS04520	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
N597_RS04530	COG2824	Alkylphosphonate utilization operon protein PhnA
N597_RS04545	COG1051	belongs to the nudix hydrolase family
N597_RS04565	COG1051	belongs to the nudix hydrolase family
N597_RS04605	COG1131	(ABC) transporter
N597_RS04625	COG0765	amino acid transport
N597_RS04630	COG1126	abc transporter atp-binding protein
N597_RS04640	COG1132	(ABC) transporter
N597_RS04655	COG0017	Asparaginyl-tRNA synthetase
N597_RS04665	COG0436	Aminotransferase
N597_RS04670	COG1846	Transcriptional regulator
N597_RS04685	COG1272	protein, Hemolysin III
N597_RS04690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N597_RS04705	COG3142	Participates in the control of copper homeostasis
N597_RS04730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N597_RS04735	COG0601	transmembrane transport
N597_RS04740	COG0747	negative chemotaxis
N597_RS04745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N597_RS04755	COG4608	Belongs to the ABC transporter superfamily
N597_RS04760	COG0444	Belongs to the ABC transporter superfamily
N597_RS04765	COG0747	negative chemotaxis
N597_RS04770	COG0406	alpha-ribazole phosphatase activity
N597_RS04775	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
N597_RS04780	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
N597_RS04790	COG0113	porphobilinogen synthase activity
N597_RS04800	COG0181	hydroxymethylbilane synthase activity
N597_RS04805	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
N597_RS04810	COG1648	precorrin-2 dehydrogenase activity
N597_RS04815	COG2096	Adenosyltransferase
N597_RS04820	COG1492	cobalamin metabolic process
N597_RS04840	COG0310	cobalt ion transport
N597_RS04890	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
N597_RS04905	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
N597_RS04910	COG1797	cobyrinic acid a,c-diamide synthase activity
N597_RS04920	COG3192	ethanolamine utilization protein
N597_RS04925	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
N597_RS04935	COG4869	propanediol catabolic process
N597_RS04950	COG1454	alcohol dehydrogenase
N597_RS04950	COG1012	belongs to the aldehyde dehydrogenase family
N597_RS04955	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
N597_RS04965	COG4302	ethanolamine ammonia-lyase activity
N597_RS04970	COG4303	Ethanolamine ammonia lyase large subunit
N597_RS05000	COG2096	Adenosyltransferase
N597_RS05015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N597_RS05040	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N597_RS05045	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
N597_RS05050	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N597_RS05100	COG2184	nucleotidyltransferase activity
N597_RS05110	COG0135	phosphoribosylanthranilate isomerase activity
N597_RS05130	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N597_RS05140	COG0077	Prephenate dehydratase
N597_RS05145	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
N597_RS05150	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
N597_RS05155	COG3679	Belongs to the UPF0342 family
N597_RS05160	COG0287	Prephenate dehydrogenase
N597_RS05165	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
N597_RS05170	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
N597_RS05175	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N597_RS05180	COG0710	3-dehydroquinate dehydratase activity
N597_RS05185	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
N597_RS05190	COG1368	sulfuric ester hydrolase activity
N597_RS05195	COG1523	belongs to the glycosyl hydrolase 13 family
N597_RS05200	COG1597	lipid kinase activity
N597_RS05205	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N597_RS05210	COG4708	membrane
N597_RS05215	COG2246	polysaccharide biosynthetic process
N597_RS05225	COG1846	Transcriptional regulator
N597_RS05235	COG0024	Methionine aminopeptidase
N597_RS05240	COG4109	DRTGG domain
N597_RS05245	COG0519	Catalyzes the synthesis of GMP from XMP
N597_RS05260	COG2217	Heavy metal translocating P-type atpase
N597_RS05295	COG0765	amino acid transport
N597_RS05300	COG1126	abc transporter atp-binding protein
N597_RS05305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N597_RS05315	COG2131	deaminase
N597_RS05325	COG0291	Belongs to the bacterial ribosomal protein bL35 family
N597_RS05335	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
N597_RS05360	COG2801	Transposase and inactivated derivatives
N597_RS05365	COG1368	sulfuric ester hydrolase activity
N597_RS05385	COG0463	Glycosyl transferase, family 2
N597_RS05405	COG1442	glycosyl transferase family 8
N597_RS05405	COG1216	Glycosyl transferase, family 2
N597_RS05425	COG0463	Glycosyl transferase, family 2
N597_RS05430	COG1216	Glycosyl transferase, family 2
N597_RS05435	COG1216	Glycosyl transferase, family 2
N597_RS05450	COG1091	dTDP-4-dehydrorhamnose reductase activity
N597_RS05465	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N597_RS05475	COG1177	transmembrane transport
N597_RS05480	COG1175	transmembrane transport
N597_RS05485	COG3842	ATPase activity
N597_RS05490	COG0812	UDP-N-acetylmuramate dehydrogenase activity
N597_RS05505	COG0460	homoserine dehydrogenase
N597_RS05510	COG0726	polysaccharide deacetylase
N597_RS05515	COG1079	Belongs to the binding-protein-dependent transport system permease family
N597_RS05520	COG4603	Belongs to the binding-protein-dependent transport system permease family
N597_RS05525	COG3845	ABC transporter
N597_RS05530	COG1744	ABC transporter substrate-binding protein PnrA-like
N597_RS05540	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
N597_RS05545	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
N597_RS05550	COG2813	Specifically methylates the guanine in position
N597_RS05555	COG1072	(Pantothenic acid kinase))
N597_RS05560	COG0268	Binds directly to 16S ribosomal RNA
N597_RS05565	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
N597_RS05585	COG1131	(ABC) transporter
N597_RS05605	COG3118	belongs to the thioredoxin family
N597_RS05615	COG4166	transmembrane transport
N597_RS05620	COG0159	tryptophan synthase activity
N597_RS05630	COG0135	phosphoribosylanthranilate isomerase activity
N597_RS05645	COG0512	Glutamine amidotransferase of anthranilate synthase
N597_RS05650	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N597_RS05655	COG1363	Peptidase, m42
N597_RS05675	COG2514	catechol 2,3-dioxygenase activity
N597_RS05700	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
N597_RS05725	COG1132	(ABC) transporter
N597_RS05730	COG1132	(ABC) transporter
N597_RS05740	COG4989	oxidoreductase activity
N597_RS05745	COG1668	transmembrane transport
N597_RS05750	COG4152	abc transporter atp-binding protein
N597_RS05760	COG1476	TRANSCRIPTIONal
N597_RS05770	COG0072	phenylalanine-tRNA ligase activity
N597_RS05770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N597_RS05790	COG1293	RNA-binding protein homologous to eukaryotic snRNP
N597_RS05795	COG3527	Alpha-acetolactate decarboxylase
N597_RS05805	COG0628	permease
N597_RS05810	COG2706	6-phosphogluconolactonase activity
N597_RS05835	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
N597_RS05840	COG0187	DNA topoisomerase II activity
N597_RS05855	COG0772	Belongs to the SEDS family
N597_RS05865	COG1199	ATP-dependent helicase activity
N597_RS05865	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N597_RS05875	COG2177	Part of the ABC transporter FtsEX involved in
N597_RS05880	COG2884	Cell division ATP-binding protein ftsE
N597_RS05885	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
N597_RS05895	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N597_RS05910	COG1078	dGTPase activity
N597_RS05920	COG2348	transferase activity, transferring amino-acyl groups
N597_RS05935	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N597_RS05940	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
N597_RS05945	COG0772	Belongs to the SEDS family
N597_RS05955	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
N597_RS05965	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
N597_RS05970	COG0577	efflux transmembrane transporter activity
N597_RS05975	COG1136	(ABC) transporter
N597_RS05985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N597_RS05990	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
N597_RS05995	COG4443	Transcriptional Coactivator p15 (PC4)
N597_RS06005	COG0826	peptidase U32
N597_RS06030	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
N597_RS06035	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
N597_RS06050	COG3091	SprT-like family
N597_RS06055	COG2183	response to ionizing radiation
N597_RS06060	COG0701	Predicted permease
N597_RS06065	COG3689	TIGRFAM TIGR03943 family protein
N597_RS06070	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
N597_RS06075	COG0552	protein localization to endoplasmic reticulum
N597_RS06080	COG0561	phosphatase activity
N597_RS06085	COG0561	phosphatase activity
N597_RS06090	COG1196	nuclear chromosome segregation
N597_RS06095	COG0571	ribonuclease III activity
N597_RS06100	COG2832	Protein of unknown function (DUF454)
N597_RS06105	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
N597_RS06110	COG5002	protein histidine kinase activity
N597_RS06115	COG0745	RESPONSE REGULATOR receiver
N597_RS06125	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
N597_RS06130	COG0438	transferase activity, transferring glycosyl groups
N597_RS06140	COG1609	Transcriptional regulator
N597_RS06145	COG0006	proline dipeptidase activity
N597_RS06180	COG0737	Belongs to the 5'-nucleotidase family
N597_RS06195	COG1346	cytolysis
N597_RS06200	COG1380	Effector of murein hydrolase LrgA
N597_RS06220	COG0557	exoribonuclease II activity
N597_RS06230	COG2814	Major facilitator Superfamily
N597_RS06235	COG0237	dephospho-CoA kinase activity
N597_RS06240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N597_RS06245	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
N597_RS06250	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
N597_RS06260	COG1132	(ABC) transporter
N597_RS06265	COG1132	(ABC) transporter
N597_RS06280	COG0686	Belongs to the AlaDH PNT family
N597_RS06285	COG1702	phosphate starvation-inducible protein PhoH
N597_RS06295	COG2996	Protein conserved in bacteria
N597_RS06305	COG0528	UMP kinase activity
N597_RS06315	COG0081	regulation of translation
N597_RS06320	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
N597_RS06330	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
N597_RS06335	COG0346	lactoylglutathione lyase activity
N597_RS06340	COG0697	spore germination
N597_RS06340	COG1674	ftsk spoiiie
N597_RS06360	COG4555	ABC transporter
N597_RS06370	COG0488	(ABC) transporter
N597_RS06375	COG1393	Belongs to the ArsC family
N597_RS06380	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N597_RS06395	COG4467	Involved in initiation control of chromosome replication
N597_RS06400	COG0470	DNA polymerase III
N597_RS06405	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
N597_RS06410	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
N597_RS06415	COG0617	tRNA 3'-terminal CCA addition
N597_RS06415	COG0517	IMP dehydrogenase activity
N597_RS06415	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
N597_RS06435	COG0559	Belongs to the binding-protein-dependent transport system permease family
N597_RS06455	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
N597_RS06460	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
N597_RS06465	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
N597_RS06470	COG0626	cystathionine gamma-synthase activity
N597_RS06475	COG2244	polysaccharide biosynthetic process
N597_RS06480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
N597_RS06500	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
N597_RS06510	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N597_RS06515	COG4120	Belongs to the binding-protein-dependent transport system permease family
N597_RS06535	COG1253	flavin adenine dinucleotide binding
N597_RS06540	COG3711	transcriptional antiterminator
N597_RS06545	COG0628	permease
N597_RS06550	COG1119	ATPase activity
N597_RS06555	COG0025	NhaP-type Na H and K H
N597_RS06565	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
N597_RS06570	COG1242	4 iron, 4 sulfur cluster binding
N597_RS06580	COG0671	phosphoesterase, PA-phosphatase related
N597_RS06585	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
N597_RS06595	COG0569	domain protein
N597_RS06600	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N597_RS06610	COG1187	pseudouridine synthase activity
N597_RS06615	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
N597_RS06620	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
N597_RS06625	COG4974	Belongs to the 'phage' integrase family
N597_RS06630	COG0517	IMP dehydrogenase activity
N597_RS06640	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N597_RS06645	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
N597_RS06670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N597_RS06675	COG1254	Belongs to the acylphosphatase family
N597_RS06690	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
N597_RS06715	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N597_RS06735	COG1484	DNA-dependent DNA replication
N597_RS06745	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
N597_RS06755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N597_RS06755	COG2190	(PTS) system
N597_RS06755	COG1263	PTS System
N597_RS06760	COG2801	Transposase and inactivated derivatives
N597_RS06770	COG0745	RESPONSE REGULATOR receiver
N597_RS06775	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
N597_RS06795	COG0501	Belongs to the peptidase M48B family
N597_RS06800	COG1704	LemA family
N597_RS06805	COG0357	Ribosomal RNA small subunit methyltransferase G
N597_RS06810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N597_RS06815	COG4221	oxidoreductase activity
N597_RS06825	COG1122	ATPase activity
N597_RS06895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N597_RS06900	COG1473	amidohydrolase
N597_RS06905	COG0217	transcriptional regulatory protein
N597_RS06915	COG2226	methyltransferase
N597_RS06920	COG0799	negative regulation of ribosome biogenesis
N597_RS06925	COG1713	HD superfamily hydrolase involved in NAD metabolism
N597_RS06930	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
N597_RS06935	COG1534	Rna-binding protein
N597_RS06940	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
N597_RS06945	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
N597_RS06960	COG1523	belongs to the glycosyl hydrolase 13 family
N597_RS06965	COG1063	alcohol dehydrogenase
N597_RS06985	COG1335	isochorismatase
N597_RS06990	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
N597_RS06995	COG0436	Aminotransferase
N597_RS07000	COG0589	response to stress
N597_RS07005	COG0561	phosphatase activity
N597_RS07010	COG0252	asparaginase activity
N597_RS07015	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
N597_RS07025	COG0736	holo-[acyl-carrier-protein] synthase activity
N597_RS07030	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N597_RS07035	COG0653	protein targeting
N597_RS07040	COG1482	cell wall glycoprotein biosynthetic process
N597_RS07045	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
N597_RS07055	COG0242	peptide deformylase activity
N597_RS07060	COG1940	carbohydrate kinase activity
N597_RS07065	COG1263	PTS System
N597_RS07065	COG2190	(PTS) system
N597_RS07065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N597_RS07070	COG1621	beta-fructofuranosidase activity
N597_RS07075	COG1609	Transcriptional regulator
N597_RS07095	COG0006	proline dipeptidase activity
N597_RS07100	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N597_RS07120	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
N597_RS07125	COG0629	single-stranded DNA binding
N597_RS07130	COG0360	Binds together with S18 to 16S ribosomal RNA
N597_RS07150	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
N597_RS07160	COG1228	amidohydrolase
N597_RS07165	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
N597_RS07175	COG3404	Formiminotransferase-cyclodeaminase
N597_RS07190	COG0531	amino acid
N597_RS07195	COG2986	histidine ammonia-lyase
N597_RS07215	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
N597_RS07230	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N597_RS07250	COG2205	protein histidine kinase activity
N597_RS07255	COG0745	RESPONSE REGULATOR receiver
N597_RS07265	COG2723	6-phospho-beta-galactosidase activity
N597_RS07275	COG0028	Belongs to the TPP enzyme family
N597_RS07285	COG0561	phosphatase activity
N597_RS07300	COG2843	Capsule synthesis protein
N597_RS07305	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N597_RS07305	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N597_RS07315	COG0167	dihydroorotate dehydrogenase activity
N597_RS07320	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
N597_RS07325	COG0484	heat shock protein binding
N597_RS07340	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
N597_RS07355	COG0588	phosphoglycerate mutase activity
N597_RS07360	COG0588	phosphoglycerate mutase activity
N597_RS07370	COG3830	Belongs to the UPF0237 family
N597_RS07385	COG3237	CsbD-like
N597_RS07395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N597_RS07420	COG2217	Heavy metal translocating P-type atpase
N597_RS07430	COG3328	transposase activity
N597_RS07435	COG1597	lipid kinase activity
N597_RS07455	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
N597_RS07465	COG3688	RNA-binding protein containing a PIN domain
N597_RS07485	COG0366	Alpha amylase catalytic
N597_RS07490	COG3842	ATPase activity
N597_RS07500	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
N597_RS07505	COG0215	cysteine-tRNA ligase activity
N597_RS07520	COG1045	serine acetyltransferase
N597_RS07540	COG1164	Oligoendopeptidase f
N597_RS07550	COG3118	belongs to the thioredoxin family
N597_RS07565	COG2801	Transposase and inactivated derivatives
N597_RS07585	COG1131	(ABC) transporter
N597_RS07595	COG3118	belongs to the thioredoxin family
N597_RS07605	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
N597_RS07615	COG1187	pseudouridine synthase activity
N597_RS07625	COG0668	transmembrane transport
N597_RS07640	COG1193	negative regulation of DNA recombination
N597_RS07655	COG0386	Belongs to the glutathione peroxidase family
N597_RS07665	COG0681	Belongs to the peptidase S26 family
N597_RS07670	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N597_RS07675	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N597_RS07680	COG1882	Formate acetyltransferase
N597_RS07700	COG3425	synthase
N597_RS07710	COG1304	FMN binding
N597_RS07725	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
N597_RS07730	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
N597_RS07755	COG2176	DNA-directed DNA polymerase activity
N597_RS07765	COG1914	H( )-stimulated, divalent metal cation uptake system
N597_RS07775	COG2081	HI0933 family
N597_RS07785	COG0789	Transcriptional regulator
N597_RS07790	COG0733	neurotransmitter:sodium symporter activity
N597_RS07810	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
N597_RS07820	COG1214	PFAM Peptidase M22, glycoprotease
N597_RS07825	COG5503	Protein of unknown function (DUF1447)
N597_RS07835	COG0174	glutamine synthetase
N597_RS07840	COG0789	Transcriptional regulator
N597_RS07850	COG0126	phosphoglycerate kinase activity
N597_RS07855	COG0366	Alpha amylase catalytic
N597_RS07885	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N597_RS07890	COG3481	metal-dependent phosphohydrolase, HD sub domain
N597_RS07900	COG1564	THIamine pyrophosphokinase
N597_RS07910	COG1162	GTPase activity
N597_RS07945	COG0084	hydrolase, TatD family'
N597_RS07950	COG0230	Belongs to the bacterial ribosomal protein bL34 family
N597_RS07960	COG1847	R3H domain protein
N597_RS07965	COG0706	membrane insertase activity
N597_RS07970	COG0594	ribonuclease P activity
N597_RS08065	COG1129	ABC transporter
N597_RS08085	COG0463	Glycosyl transferase, family 2
N597_RS08110	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
N597_RS08125	COG0756	dUTP diphosphatase activity
N597_RS08130	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
N597_RS08140	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
N597_RS08145	COG1210	Utp--glucose-1-phosphate uridylyltransferase
N597_RS08160	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N597_RS08205	COG0166	Belongs to the GPI family
N597_RS08215	COG3732	PTS system glucitol sorbitol-specific
N597_RS08220	COG3730	PTS system glucitol sorbitol-specific
N597_RS08240	COG0166	Belongs to the GPI family
N597_RS08250	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
N597_RS08255	COG2918	glutathione biosynthetic process
N597_RS08255	COG1181	Belongs to the D-alanine--D-alanine ligase family
N597_RS08265	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
N597_RS08270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N597_RS08280	COG3201	nicotinamide mononucleotide transporter
N597_RS08285	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
N597_RS08310	COG4463	regulation of RNA biosynthetic process
N597_RS08320	COG3250	beta-galactosidase activity
N597_RS08330	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
N597_RS08360	COG2321	neutral zinc metallopeptidase
N597_RS08365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N597_RS08370	COG0564	pseudouridine synthase activity
N597_RS08380	COG0803	Belongs to the bacterial solute-binding protein 9 family
N597_RS08405	COG0438	transferase activity, transferring glycosyl groups
N597_RS08410	COG0562	UDP-galactopyranose mutase
N597_RS08425	COG1063	alcohol dehydrogenase
N597_RS08430	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
N597_RS08435	COG1215	transferase activity, transferring glycosyl groups
N597_RS08440	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
N597_RS08445	COG0438	transferase activity, transferring glycosyl groups
N597_RS08450	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
N597_RS08455	COG3475	LICD family
N597_RS08465	COG0489	protein tyrosine kinase activity
N597_RS08470	COG3944	biosynthesis protein
N597_RS08475	COG4464	protein tyrosine phosphatase activity
N597_RS08480	COG1316	TRANSCRIPTIONal
N597_RS08490	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N597_RS08500	COG0285	dihydrofolate synthase activity
N597_RS08505	COG3906	Belongs to the UPF0473 family
N597_RS08510	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
N597_RS08515	COG4472	Bacterial protein of unknown function (DUF965)
N597_RS08530	COG1393	Belongs to the ArsC family
N597_RS08540	COG1058	Belongs to the CinA family
N597_RS08540	COG1546	Belongs to the CinA family
N597_RS08550	COG2818	Glycosylase
N597_RS08560	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
N597_RS08575	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
N597_RS08580	COG1438	arginine binding
N597_RS08585	COG0018	arginyl-trna synthetase
N597_RS08595	COG1780	Probably involved in ribonucleotide reductase function
N597_RS08605	COG0058	SHG alpha-glucan phosphorylase activity
N597_RS08610	COG1640	4-alpha-glucanotransferase
N597_RS08615	COG2182	Extracellular solute-binding protein
N597_RS08620	COG1175	transmembrane transport
N597_RS08625	COG3833	ABC-type maltose transport systems, permease component
N597_RS08635	COG5521	maltodextrose utilization protein MalA
N597_RS08640	COG1609	Transcriptional regulator
N597_RS08645	COG1523	belongs to the glycosyl hydrolase 13 family
N597_RS08650	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
N597_RS08665	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
N597_RS08670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N597_RS08675	COG1696	Membrane protein involved in D-alanine export
N597_RS08700	COG1511	domain protein
N597_RS08710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N597_RS08715	COG2274	protein secretion by the type I secretion system
N597_RS08720	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
N597_RS08730	COG0305	Participates in initiation and elongation during chromosome replication
N597_RS08735	COG0359	binds to the 23S rRNA
N597_RS08745	COG0445	tRNA wobble uridine modification
N597_RS08750	COG0494	nUDIX hydrolase
N597_RS08765	COG1760	l-serine dehydratase
N597_RS08770	COG1760	l-serine dehydratase
N597_RS08775	COG0546	phosphoglycolate phosphatase activity
N597_RS08780	COG0741	lytic transglycosylase activity
N597_RS08785	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
N597_RS08790	COG1122	ATPase activity
N597_RS08795	COG1122	ATPase activity
N597_RS08800	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N597_RS08805	COG0612	Peptidase, M16
N597_RS08820	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
N597_RS08825	COG0517	IMP dehydrogenase activity
N597_RS08825	COG0516	GMP reductase activity
N597_RS08835	COG0488	(ABC) transporter
N597_RS08870	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
N597_RS08875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N597_RS08880	COG1475	DNA binding
N597_RS08890	COG0592	DNA-directed DNA polymerase activity
N597_RS08905	COG0012	GTP binding
N597_RS08910	COG0193	aminoacyl-tRNA hydrolase activity
N597_RS08915	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
N597_RS08920	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
N597_RS08935	COG0037	tRNA processing
N597_RS08940	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
N597_RS08945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N597_RS09070	COG3942	CHAP domain
N597_RS09075	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N597_RS09095	COG0436	Aminotransferase
N597_RS09100	COG1381	Involved in DNA repair and RecF pathway recombination
N597_RS09110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N597_RS09120	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N597_RS09130	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
N597_RS09135	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
N597_RS09140	COG0138	bifunctional purine biosynthesis protein purh
N597_RS09145	COG3942	CHAP domain
N597_RS09150	COG0151	Belongs to the GarS family
N597_RS09155	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
N597_RS09170	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N597_RS09175	COG2188	Transcriptional regulator
N597_RS09185	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N597_RS09190	COG3715	PTS system
N597_RS09195	COG3716	PTS system mannose fructose sorbose family IID component
N597_RS09205	COG2222	sugar isomerase
N597_RS09215	COG2255	four-way junction helicase activity
N597_RS09225	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N597_RS09235	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
N597_RS09235	COG2755	lipolytic protein G-D-S-L family
N597_RS09240	COG1454	alcohol dehydrogenase
N597_RS09240	COG1012	belongs to the aldehyde dehydrogenase family
N597_RS09245	COG1063	alcohol dehydrogenase
N597_RS09270	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
N597_RS09280	COG1653	transport
N597_RS09285	COG1175	transmembrane transport
N597_RS09295	COG0673	inositol 2-dehydrogenase activity
N597_RS09300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N597_RS09320	COG1269	ATP hydrolysis coupled proton transport
N597_RS09325	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N597_RS09335	COG1527	subunit (C
N597_RS09350	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
N597_RS09355	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
N597_RS09360	COG1394	ATPase activity, coupled to movement of substances
N597_RS09370	COG2807	transmembrane transport
N597_RS09375	COG2151	metal-sulfur cluster biosynthetic enzyme
N597_RS09390	COG0267	Belongs to the bacterial ribosomal protein bL33 family
N597_RS09405	COG1131	(ABC) transporter
N597_RS09420	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N597_RS09430	COG4932	domain protein
N597_RS09430	COG1388	LysM domain
N597_RS09450	COG1328	CTP reductase activity
N597_RS09470	COG0534	Mate efflux family protein
N597_RS09475	COG0546	phosphoglycolate phosphatase activity
N597_RS09490	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N597_RS09490	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N597_RS09495	COG1832	CoA-binding protein
N597_RS09520	COG0088	Forms part of the polypeptide exit tunnel
N597_RS09535	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N597_RS09545	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
N597_RS09555	COG0255	Belongs to the universal ribosomal protein uL29 family
N597_RS09560	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
N597_RS09565	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
N597_RS09570	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
N597_RS09575	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
N597_RS09580	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
N597_RS09600	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
N597_RS09605	COG1841	ribosomal large subunit assembly
N597_RS09615	COG0201	protein transport
N597_RS09625	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
N597_RS09630	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N597_RS09635	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
N597_RS09640	COG0202	RNA polymerase activity
N597_RS09715	COG3290	protein histidine kinase activity