locus-tag	class	description
D7D50_RS00010	COG0588	phosphoglycerate mutase activity
D7D50_RS00030	COG1307	EDD domain protein, DegV family
D7D50_RS00035	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D7D50_RS00040	COG0497	DNA recombination
D7D50_RS00045	COG1438	arginine binding
D7D50_RS00050	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
D7D50_RS00060	COG1722	exodeoxyribonuclease VII activity
D7D50_RS00065	COG1570	exodeoxyribonuclease VII activity
D7D50_RS00070	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D7D50_RS00080	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D7D50_RS00090	COG4703	Protein of unknown function (DUF1797)
D7D50_RS00095	COG0542	response to heat
D7D50_RS00105	COG0494	nUDIX hydrolase
D7D50_RS00120	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D7D50_RS00125	COG3599	regulation of cell shape
D7D50_RS00140	COG1799	cell septum assembly
D7D50_RS00145	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D7D50_RS00150	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D7D50_RS00160	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D7D50_RS00185	COG1217	gtp-binding protein TYPA
D7D50_RS00190	COG1187	pseudouridine synthase activity
D7D50_RS00225	COG0133	tryptophan synthase activity
D7D50_RS00235	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D7D50_RS00240	COG4470	Protein conserved in bacteria
D7D50_RS00250	COG3480	Lon protease (S16) C-terminal proteolytic domain
D7D50_RS00255	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D7D50_RS00260	COG0742	ribosomal rna small subunit methyltransferase
D7D50_RS00270	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D7D50_RS00325	COG0525	valine-tRNA ligase activity
D7D50_RS00340	COG0519	Catalyzes the synthesis of GMP from XMP
D7D50_RS00365	COG0295	cytidine deaminase activity
D7D50_RS00370	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D7D50_RS00470	COG1040	competence protein
D7D50_RS00475	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
D7D50_RS00480	COG1739	Uncharacterized protein family UPF0029
D7D50_RS00490	COG1185	polyribonucleotide nucleotidyltransferase activity
D7D50_RS00500	COG2197	response regulator
D7D50_RS00505	COG4585	Histidine kinase
D7D50_RS00515	COG2815	serine threonine protein kinase
D7D50_RS00515	COG0515	serine threonine protein kinase
D7D50_RS00520	COG0631	protein serine/threonine phosphatase activity
D7D50_RS00525	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D7D50_RS00525	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D7D50_RS00530	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D7D50_RS00535	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D7D50_RS00540	COG1758	RNA polymerase activity
D7D50_RS00545	COG0194	GDP metabolic process
D7D50_RS00550	COG1418	mRNA catabolic process
D7D50_RS00555	COG1854	S-ribosylhomocysteine lyase activity
D7D50_RS00570	COG0116	Belongs to the methyltransferase superfamily
D7D50_RS00585	COG4474	Belongs to the UPF0398 family
D7D50_RS00590	COG3331	DNA recombination
D7D50_RS00595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D7D50_RS00600	COG3579	cysteine-type endopeptidase activity
D7D50_RS00605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D7D50_RS00615	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D7D50_RS00620	COG0492	ferredoxin-NADP+ reductase activity
D7D50_RS00630	COG1126	abc transporter atp-binding protein
D7D50_RS00635	COG0765	amino acid transport
D7D50_RS00640	COG0513	Belongs to the DEAD box helicase family
D7D50_RS00645	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D7D50_RS00650	COG0768	penicillin binding
D7D50_RS00690	COG0656	L-ascorbic acid biosynthetic process
D7D50_RS00710	COG1283	sodium-dependent phosphate transmembrane transporter activity
D7D50_RS00715	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D7D50_RS00730	COG2740	Nucleic-acid-binding protein implicated in transcription termination
D7D50_RS00735	COG0195	Participates in both transcription termination and antitermination
D7D50_RS00740	COG0779	Required for maturation of 30S ribosomal subunits
D7D50_RS00745	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D7D50_RS00760	COG1131	(ABC) transporter
D7D50_RS00765	COG0537	adenosine 5'-monophosphoramidase activity
D7D50_RS00775	COG1316	TRANSCRIPTIONal
D7D50_RS00785	COG0802	atpase or kinase
D7D50_RS00790	COG2252	PERMEase
D7D50_RS00795	COG0561	phosphatase activity
D7D50_RS00800	COG1064	alcohol dehydrogenase
D7D50_RS00810	COG3715	PTS system
D7D50_RS00815	COG3716	PTS system mannose fructose sorbose family IID component
D7D50_RS00830	COG0825	malonyl-CoA metabolic process
D7D50_RS00835	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D7D50_RS00840	COG0439	Biotin carboxylase
D7D50_RS00855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D7D50_RS00860	COG1028	Short-chain dehydrogenase reductase Sdr
D7D50_RS00865	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D7D50_RS00890	COG1024	Enoyl-CoA hydratase
D7D50_RS00895	COG0527	aspartate kinase activity
D7D50_RS00925	COG4608	Belongs to the ABC transporter superfamily
D7D50_RS00930	COG0444	Belongs to the ABC transporter superfamily
D7D50_RS00935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D7D50_RS00940	COG0601	transmembrane transport
D7D50_RS00945	COG4166	transmembrane transport
D7D50_RS00950	COG4166	transmembrane transport
D7D50_RS00955	COG1686	Belongs to the peptidase S11 family
D7D50_RS00970	COG0719	Fe-S assembly protein
D7D50_RS00980	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D7D50_RS00985	COG0719	Fe-S assembly protein
D7D50_RS00995	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D7D50_RS01000	COG4862	establishment of competence for transformation
D7D50_RS01005	COG1968	undecaprenyl-diphosphatase activity
D7D50_RS01020	COG0765	amino acid transport
D7D50_RS01025	COG1126	abc transporter atp-binding protein
D7D50_RS01040	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D7D50_RS01045	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D7D50_RS01050	COG0440	acetolactate synthase activity
D7D50_RS01055	COG0028	Belongs to the TPP enzyme family
D7D50_RS01065	COG2197	response regulator
D7D50_RS01070	COG4585	Histidine kinase
D7D50_RS01075	COG0842	Transport permease protein
D7D50_RS01080	COG1131	(ABC) transporter
D7D50_RS01100	COG1461	Dihydroxyacetone kinase
D7D50_RS01110	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D7D50_RS01155	COG0561	phosphatase activity
D7D50_RS01160	COG0210	DNA helicase
D7D50_RS01170	COG0542	response to heat
D7D50_RS01230	COG3620	sequence-specific DNA binding
D7D50_RS01245	COG1476	TRANSCRIPTIONal
D7D50_RS01265	COG1674	ftsk spoiiie
D7D50_RS01300	COG0433	COG0433 Predicted ATPase
D7D50_RS01315	COG1705	Flagellar rod assembly protein muramidase FlgJ
D7D50_RS01315	COG3942	CHAP domain
D7D50_RS01325	COG0582	viral genome integration into host DNA
D7D50_RS01350	COG3711	transcriptional antiterminator
D7D50_RS01355	COG3684	Belongs to the aldolase LacD family
D7D50_RS01365	COG0698	ribose 5-phosphate isomerase
D7D50_RS01375	COG1349	DNA-binding transcription factor activity
D7D50_RS01380	COG0191	fructose-bisphosphate aldolase activity
D7D50_RS01405	COG3343	RNA polymerase activity
D7D50_RS01410	COG0544	peptidyl-prolyl cis-trans isomerase activity
D7D50_RS01415	COG4475	Protein of unknown function (DUF436)
D7D50_RS01420	COG4720	Psort location CytoplasmicMembrane, score
D7D50_RS01425	COG0351	phosphomethylpyrimidine kinase
D7D50_RS01435	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D7D50_RS01435	COG3583	domain protein
D7D50_RS01435	COG3064	Membrane
D7D50_RS01440	COG2309	aminopeptidase activity
D7D50_RS01450	COG3041	Addiction module toxin RelE StbE family
D7D50_RS01470	COG2176	DNA-directed DNA polymerase activity
D7D50_RS01485	COG4589	Belongs to the CDS family
D7D50_RS01490	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D7D50_RS01510	COG1126	abc transporter atp-binding protein
D7D50_RS01515	COG0765	amino acid transport
D7D50_RS01520	COG0765	amino acid transport
D7D50_RS01525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D7D50_RS01545	COG0561	phosphatase activity
D7D50_RS01550	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D7D50_RS01570	COG2723	6-phospho-beta-galactosidase activity
D7D50_RS01575	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D7D50_RS01620	COG4166	transmembrane transport
D7D50_RS01675	COG1882	Formate acetyltransferase
D7D50_RS01680	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D7D50_RS01690	COG1447	Phosphotransferase system cellobiose-specific component IIA
D7D50_RS01695	COG2390	Transcriptional regulator
D7D50_RS01700	COG1349	DNA-binding transcription factor activity
D7D50_RS01710	COG3590	peptidase
D7D50_RS01745	COG1490	D-aminoacyl-tRNA deacylase activity
D7D50_RS01755	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D7D50_RS01760	COG2264	protein methyltransferase activity
D7D50_RS01790	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D7D50_RS01855	COG0577	efflux transmembrane transporter activity
D7D50_RS01860	COG1136	(ABC) transporter
D7D50_RS01865	COG5002	protein histidine kinase activity
D7D50_RS01870	COG0745	RESPONSE REGULATOR receiver
D7D50_RS01880	COG1136	(ABC) transporter
D7D50_RS01905	COG3716	PTS system mannose fructose sorbose family IID component
D7D50_RS01930	COG2197	response regulator
D7D50_RS01935	COG4585	Histidine kinase
D7D50_RS01940	COG1609	Transcriptional regulator
D7D50_RS01955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D7D50_RS01960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D7D50_RS01970	COG1363	Peptidase, m42
D7D50_RS01975	COG4868	Belongs to the UPF0371 family
D7D50_RS01980	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D7D50_RS01980	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D7D50_RS01985	COG0302	gtp cyclohydrolase
D7D50_RS01990	COG0285	dihydrofolate synthase activity
D7D50_RS01995	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D7D50_RS02000	COG1266	CAAX protease self-immunity
D7D50_RS02005	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D7D50_RS02010	COG0827	DNA restriction-modification system
D7D50_RS02035	COG4537	Required for transformation and DNA binding
D7D50_RS02040	COG1459	type II secretion system
D7D50_RS02045	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D7D50_RS02060	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
D7D50_RS02065	COG1215	transferase activity, transferring glycosyl groups
D7D50_RS02085	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D7D50_RS02090	COG0085	RNA polymerase activity
D7D50_RS02095	COG4499	WXG100 protein secretion system (Wss), protein YukC
D7D50_RS02095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D7D50_RS02105	COG2226	methyltransferase
D7D50_RS02110	COG2207	Transcriptional regulator
D7D50_RS02110	COG4753	response regulator
D7D50_RS02115	COG2972	Histidine kinase
D7D50_RS02125	COG1653	transport
D7D50_RS02130	COG0395	ABC-type sugar transport system, permease component
D7D50_RS02135	COG4209	transmembrane transport
D7D50_RS02150	COG0383	alpha-mannosidase activity
D7D50_RS02175	COG0803	Belongs to the bacterial solute-binding protein 9 family
D7D50_RS02175	COG3443	Belongs to the bacterial solute-binding protein 9 family
D7D50_RS02180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D7D50_RS02185	COG1121	(ABC) transporter
D7D50_RS02190	COG1846	Transcriptional regulator
D7D50_RS02205	COG2249	NAD(P)H dehydrogenase (quinone) activity
D7D50_RS02210	COG1309	transcriptional regulator
D7D50_RS02340	COG0202	RNA polymerase activity
D7D50_RS02345	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D7D50_RS02350	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D7D50_RS02355	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D7D50_RS02360	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D7D50_RS02370	COG0201	protein transport
D7D50_RS02380	COG1841	ribosomal large subunit assembly
D7D50_RS02385	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D7D50_RS02405	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D7D50_RS02410	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D7D50_RS02415	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D7D50_RS02420	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D7D50_RS02425	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D7D50_RS02430	COG0255	Belongs to the universal ribosomal protein uL29 family
D7D50_RS02440	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D7D50_RS02450	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D7D50_RS02465	COG0088	Forms part of the polypeptide exit tunnel
D7D50_RS02490	COG1832	CoA-binding protein
D7D50_RS02495	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D7D50_RS02495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D7D50_RS02500	COG3759	membrane
D7D50_RS02515	COG0546	phosphoglycolate phosphatase activity
D7D50_RS02520	COG0534	Mate efflux family protein
D7D50_RS02545	COG1328	CTP reductase activity
D7D50_RS02565	COG1388	LysM domain
D7D50_RS02565	COG4932	domain protein
D7D50_RS02570	COG2184	nucleotidyltransferase activity
D7D50_RS02580	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D7D50_RS02605	COG2151	metal-sulfur cluster biosynthetic enzyme
D7D50_RS02610	COG2807	transmembrane transport
D7D50_RS02625	COG1394	ATPase activity, coupled to movement of substances
D7D50_RS02630	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
D7D50_RS02635	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
D7D50_RS02650	COG1527	subunit (C
D7D50_RS02660	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D7D50_RS02665	COG1269	ATP hydrolysis coupled proton transport
D7D50_RS02690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D7D50_RS02700	COG2731	YhcH YjgK YiaL family protein
D7D50_RS02705	COG0395	ABC-type sugar transport system, permease component
D7D50_RS02710	COG1175	transmembrane transport
D7D50_RS02720	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
D7D50_RS02745	COG1063	alcohol dehydrogenase
D7D50_RS02750	COG1012	belongs to the aldehyde dehydrogenase family
D7D50_RS02750	COG1454	alcohol dehydrogenase
D7D50_RS02755	COG2755	lipolytic protein G-D-S-L family
D7D50_RS02755	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D7D50_RS02765	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D7D50_RS02775	COG2255	four-way junction helicase activity
D7D50_RS02790	COG2222	sugar isomerase
D7D50_RS02800	COG3716	PTS system mannose fructose sorbose family IID component
D7D50_RS02805	COG3715	PTS system
D7D50_RS02810	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D7D50_RS02820	COG2188	Transcriptional regulator
D7D50_RS02830	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D7D50_RS02845	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D7D50_RS02850	COG0151	Belongs to the GarS family
D7D50_RS02855	COG3942	CHAP domain
D7D50_RS02860	COG0138	bifunctional purine biosynthesis protein purh
D7D50_RS02865	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D7D50_RS02870	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D7D50_RS02880	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D7D50_RS02890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D7D50_RS02900	COG1381	Involved in DNA repair and RecF pathway recombination
D7D50_RS02905	COG0436	Aminotransferase
D7D50_RS02925	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D7D50_RS02930	COG3942	CHAP domain
D7D50_RS03060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D7D50_RS03065	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D7D50_RS03070	COG0037	tRNA processing
D7D50_RS03085	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D7D50_RS03090	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D7D50_RS03095	COG0193	aminoacyl-tRNA hydrolase activity
D7D50_RS03100	COG0012	GTP binding
D7D50_RS03120	COG0592	DNA-directed DNA polymerase activity
D7D50_RS03130	COG1475	DNA binding
D7D50_RS03135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D7D50_RS03140	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D7D50_RS03155	COG3290	protein histidine kinase activity
D7D50_RS03185	COG0488	(ABC) transporter
D7D50_RS03195	COG0516	GMP reductase activity
D7D50_RS03195	COG0517	IMP dehydrogenase activity
D7D50_RS03200	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D7D50_RS03205	COG2501	S4 domain
D7D50_RS03215	COG0612	Peptidase, M16
D7D50_RS03220	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D7D50_RS03225	COG1122	ATPase activity
D7D50_RS03230	COG1122	ATPase activity
D7D50_RS03235	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D7D50_RS03240	COG0741	lytic transglycosylase activity
D7D50_RS03245	COG0546	phosphoglycolate phosphatase activity
D7D50_RS03250	COG1760	l-serine dehydratase
D7D50_RS03255	COG1760	l-serine dehydratase
D7D50_RS03270	COG0494	nUDIX hydrolase
D7D50_RS03275	COG0445	tRNA wobble uridine modification
D7D50_RS03285	COG0359	binds to the 23S rRNA
D7D50_RS03290	COG0305	Participates in initiation and elongation during chromosome replication
D7D50_RS03300	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D7D50_RS03305	COG2274	protein secretion by the type I secretion system
D7D50_RS03310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D7D50_RS03320	COG1511	domain protein
D7D50_RS03345	COG1696	Membrane protein involved in D-alanine export
D7D50_RS03350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D7D50_RS03355	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
D7D50_RS03370	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D7D50_RS03375	COG1523	belongs to the glycosyl hydrolase 13 family
D7D50_RS03380	COG1609	Transcriptional regulator
D7D50_RS03385	COG5521	maltodextrose utilization protein MalA
D7D50_RS03390	COG3833	ABC-type maltose transport systems, permease component
D7D50_RS03395	COG1175	transmembrane transport
D7D50_RS03400	COG2182	Extracellular solute-binding protein
D7D50_RS03405	COG1640	4-alpha-glucanotransferase
D7D50_RS03410	COG0058	SHG alpha-glucan phosphorylase activity
D7D50_RS03420	COG1780	Probably involved in ribonucleotide reductase function
D7D50_RS03430	COG0018	arginyl-trna synthetase
D7D50_RS03435	COG1438	arginine binding
D7D50_RS03440	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D7D50_RS03460	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D7D50_RS03470	COG2818	Glycosylase
D7D50_RS03480	COG1058	Belongs to the CinA family
D7D50_RS03480	COG1546	Belongs to the CinA family
D7D50_RS03490	COG1393	Belongs to the ArsC family
D7D50_RS03505	COG4472	Bacterial protein of unknown function (DUF965)
D7D50_RS03515	COG3906	Belongs to the UPF0473 family
D7D50_RS03520	COG0285	dihydrofolate synthase activity
D7D50_RS03535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D7D50_RS03545	COG1316	TRANSCRIPTIONal
D7D50_RS03550	COG4464	protein tyrosine phosphatase activity
D7D50_RS03555	COG3944	biosynthesis protein
D7D50_RS03560	COG0489	protein tyrosine kinase activity
D7D50_RS03575	COG0297	glycogen (starch) synthase activity
D7D50_RS03580	COG1216	Glycosyl transferase, family 2
D7D50_RS03580	COG1442	glycosyl transferase family 8
D7D50_RS03585	COG1216	Glycosyl transferase, family 2
D7D50_RS03600	COG3274	enterobacterial common antigen metabolic process
D7D50_RS03605	COG0562	UDP-galactopyranose mutase
D7D50_RS03615	COG0438	transferase activity, transferring glycosyl groups
D7D50_RS03630	COG0803	Belongs to the bacterial solute-binding protein 9 family
D7D50_RS03645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D7D50_RS03650	COG2321	neutral zinc metallopeptidase
D7D50_RS03655	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D7D50_RS03685	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D7D50_RS03695	COG3250	beta-galactosidase activity
D7D50_RS03705	COG4463	regulation of RNA biosynthetic process
D7D50_RS03730	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D7D50_RS03735	COG3201	nicotinamide mononucleotide transporter
D7D50_RS03750	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D7D50_RS03755	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D7D50_RS03760	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D7D50_RS03780	COG0166	Belongs to the GPI family
D7D50_RS03825	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D7D50_RS03840	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D7D50_RS03845	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D7D50_RS03850	COG4932	domain protein
D7D50_RS03850	COG1388	LysM domain
D7D50_RS03855	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D7D50_RS03860	COG0756	dUTP diphosphatase activity
D7D50_RS03905	COG0463	Glycosyl transferase, family 2
D7D50_RS03930	COG1129	ABC transporter
D7D50_RS04030	COG0594	ribonuclease P activity
D7D50_RS04035	COG0706	membrane insertase activity
D7D50_RS04040	COG1847	R3H domain protein
D7D50_RS04050	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D7D50_RS04055	COG0084	hydrolase, TatD family'
D7D50_RS04095	COG1162	GTPase activity
D7D50_RS04105	COG1564	THIamine pyrophosphokinase
D7D50_RS04115	COG3481	metal-dependent phosphohydrolase, HD sub domain
D7D50_RS04120	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D7D50_RS04155	COG0366	Alpha amylase catalytic
D7D50_RS04160	COG0126	phosphoglycerate kinase activity
D7D50_RS04170	COG0789	Transcriptional regulator
D7D50_RS04175	COG0174	glutamine synthetase
D7D50_RS04185	COG5503	Protein of unknown function (DUF1447)
D7D50_RS04190	COG1214	PFAM Peptidase M22, glycoprotease
D7D50_RS04220	COG0733	neurotransmitter:sodium symporter activity
D7D50_RS04235	COG0789	Transcriptional regulator
D7D50_RS04245	COG2081	HI0933 family
D7D50_RS04255	COG1914	H( )-stimulated, divalent metal cation uptake system
D7D50_RS04305	COG3620	sequence-specific DNA binding
D7D50_RS04320	COG3620	sequence-specific DNA binding
D7D50_RS04340	COG1674	ftsk spoiiie
D7D50_RS04375	COG0433	COG0433 Predicted ATPase
D7D50_RS04390	COG1705	Flagellar rod assembly protein muramidase FlgJ
D7D50_RS04390	COG3942	CHAP domain
D7D50_RS04400	COG0582	viral genome integration into host DNA
D7D50_RS04415	COG2176	DNA-directed DNA polymerase activity
D7D50_RS04440	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D7D50_RS04445	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D7D50_RS04470	COG3425	synthase
D7D50_RS04495	COG1882	Formate acetyltransferase
D7D50_RS04500	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D7D50_RS04505	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D7D50_RS04515	COG0681	Belongs to the peptidase S26 family
D7D50_RS04525	COG0386	Belongs to the glutathione peroxidase family
D7D50_RS04540	COG1193	negative regulation of DNA recombination
D7D50_RS04550	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
D7D50_RS04555	COG0668	transmembrane transport
D7D50_RS04565	COG1187	pseudouridine synthase activity
D7D50_RS04575	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D7D50_RS04585	COG3118	belongs to the thioredoxin family
D7D50_RS04595	COG1131	(ABC) transporter
D7D50_RS04615	COG1164	Oligoendopeptidase f
D7D50_RS04635	COG1045	serine acetyltransferase
D7D50_RS04650	COG0215	cysteine-tRNA ligase activity
D7D50_RS04655	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
D7D50_RS04665	COG3842	ATPase activity
D7D50_RS04670	COG0366	Alpha amylase catalytic
D7D50_RS04690	COG3688	RNA-binding protein containing a PIN domain
D7D50_RS04700	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D7D50_RS04730	COG1597	lipid kinase activity
D7D50_RS04745	COG2217	Heavy metal translocating P-type atpase
D7D50_RS04785	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D7D50_RS04810	COG3118	belongs to the thioredoxin family
D7D50_RS04815	COG0492	ferredoxin-NADP+ reductase activity
D7D50_RS04840	COG3237	CsbD-like
D7D50_RS04860	COG3830	Belongs to the UPF0237 family
D7D50_RS04870	COG0588	phosphoglycerate mutase activity
D7D50_RS04875	COG0588	phosphoglycerate mutase activity
D7D50_RS04880	COG1876	peptidase activity
D7D50_RS04890	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D7D50_RS04905	COG0484	heat shock protein binding
D7D50_RS04915	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D7D50_RS04920	COG0167	dihydroorotate dehydrogenase activity
D7D50_RS04930	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D7D50_RS04930	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D7D50_RS04935	COG2843	Capsule synthesis protein
D7D50_RS04940	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D7D50_RS04945	COG2207	Transcriptional regulator
D7D50_RS04950	COG0561	phosphatase activity
D7D50_RS04960	COG0028	Belongs to the TPP enzyme family
D7D50_RS04970	COG2723	6-phospho-beta-galactosidase activity
D7D50_RS04980	COG0745	RESPONSE REGULATOR receiver
D7D50_RS04985	COG2205	protein histidine kinase activity
D7D50_RS05010	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D7D50_RS05025	COG0366	Alpha amylase catalytic
D7D50_RS05035	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D7D50_RS05055	COG2986	histidine ammonia-lyase
D7D50_RS05060	COG0531	amino acid
D7D50_RS05075	COG3404	Formiminotransferase-cyclodeaminase
D7D50_RS05085	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D7D50_RS05090	COG1228	amidohydrolase
D7D50_RS05100	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
D7D50_RS05135	COG0360	Binds together with S18 to 16S ribosomal RNA
D7D50_RS05140	COG0629	single-stranded DNA binding
D7D50_RS05145	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D7D50_RS05170	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D7D50_RS05175	COG0006	proline dipeptidase activity
D7D50_RS05195	COG1609	Transcriptional regulator
D7D50_RS05200	COG1621	beta-fructofuranosidase activity
D7D50_RS05205	COG1263	PTS System
D7D50_RS05205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D7D50_RS05205	COG2190	(PTS) system
D7D50_RS05210	COG1940	carbohydrate kinase activity
D7D50_RS05215	COG0242	peptide deformylase activity
D7D50_RS05230	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D7D50_RS05235	COG1482	cell wall glycoprotein biosynthetic process
D7D50_RS05240	COG0653	protein targeting
D7D50_RS05245	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D7D50_RS05250	COG0736	holo-[acyl-carrier-protein] synthase activity
D7D50_RS05260	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D7D50_RS05270	COG0252	asparaginase activity
D7D50_RS05275	COG0561	phosphatase activity
D7D50_RS05280	COG0589	response to stress
D7D50_RS05285	COG0436	Aminotransferase
D7D50_RS05290	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
D7D50_RS05295	COG1335	isochorismatase
D7D50_RS05315	COG1063	alcohol dehydrogenase
D7D50_RS05320	COG1523	belongs to the glycosyl hydrolase 13 family
D7D50_RS05335	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
D7D50_RS05340	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D7D50_RS05345	COG1534	Rna-binding protein
D7D50_RS05350	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D7D50_RS05355	COG1713	HD superfamily hydrolase involved in NAD metabolism
D7D50_RS05360	COG1335	isochorismatase
D7D50_RS05365	COG0799	negative regulation of ribosome biogenesis
D7D50_RS05370	COG2226	methyltransferase
D7D50_RS05380	COG0217	transcriptional regulatory protein
D7D50_RS05385	COG1473	amidohydrolase
D7D50_RS05390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D7D50_RS05460	COG1122	ATPase activity
D7D50_RS05470	COG4221	oxidoreductase activity
D7D50_RS05475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D7D50_RS05480	COG0357	Ribosomal RNA small subunit methyltransferase G
D7D50_RS05485	COG1704	LemA family
D7D50_RS05490	COG0501	Belongs to the peptidase M48B family
D7D50_RS05510	COG2268	Band 7 protein
D7D50_RS05515	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D7D50_RS05520	COG0745	RESPONSE REGULATOR receiver
D7D50_RS05525	COG2190	(PTS) system
D7D50_RS05525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D7D50_RS05525	COG1263	PTS System
D7D50_RS05535	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D7D50_RS05545	COG1484	DNA-dependent DNA replication
D7D50_RS05565	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D7D50_RS05590	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D7D50_RS05610	COG1254	Belongs to the acylphosphatase family
D7D50_RS05615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D7D50_RS05640	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D7D50_RS05645	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D7D50_RS05655	COG0517	IMP dehydrogenase activity
D7D50_RS05660	COG4974	Belongs to the 'phage' integrase family
D7D50_RS05665	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D7D50_RS05670	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D7D50_RS05675	COG1187	pseudouridine synthase activity
D7D50_RS05690	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D7D50_RS05695	COG0569	domain protein
D7D50_RS05705	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
D7D50_RS05710	COG0671	phosphoesterase, PA-phosphatase related
D7D50_RS05720	COG1242	4 iron, 4 sulfur cluster binding
D7D50_RS05725	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D7D50_RS05740	COG1119	ATPase activity
D7D50_RS05745	COG0628	permease
D7D50_RS05755	COG3711	transcriptional antiterminator
D7D50_RS05760	COG1253	flavin adenine dinucleotide binding
D7D50_RS05780	COG4120	Belongs to the binding-protein-dependent transport system permease family
D7D50_RS05785	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D7D50_RS05790	COG0366	Alpha amylase catalytic
D7D50_RS05800	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D7D50_RS05820	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D7D50_RS05825	COG2244	polysaccharide biosynthetic process
D7D50_RS05830	COG0626	cystathionine gamma-synthase activity
D7D50_RS05835	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D7D50_RS05840	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D7D50_RS05845	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D7D50_RS05890	COG0617	tRNA 3'-terminal CCA addition
D7D50_RS05890	COG0517	IMP dehydrogenase activity
D7D50_RS05890	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D7D50_RS05895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D7D50_RS05900	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D7D50_RS05905	COG0470	DNA polymerase III
D7D50_RS05910	COG4467	Involved in initiation control of chromosome replication
D7D50_RS05925	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D7D50_RS05930	COG1393	Belongs to the ArsC family
D7D50_RS05935	COG0488	(ABC) transporter
D7D50_RS05945	COG4555	ABC transporter
D7D50_RS05965	COG1674	ftsk spoiiie
D7D50_RS05965	COG0697	spore germination
D7D50_RS05970	COG0346	lactoylglutathione lyase activity
D7D50_RS05975	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D7D50_RS05985	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D7D50_RS05990	COG0081	regulation of translation
D7D50_RS06000	COG0528	UMP kinase activity
D7D50_RS06010	COG2996	Protein conserved in bacteria
D7D50_RS06020	COG1702	phosphate starvation-inducible protein PhoH
D7D50_RS06025	COG0686	Belongs to the AlaDH PNT family
D7D50_RS06040	COG1132	(ABC) transporter
D7D50_RS06045	COG1132	(ABC) transporter
D7D50_RS06055	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D7D50_RS06060	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D7D50_RS06065	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D7D50_RS06070	COG0237	dephospho-CoA kinase activity
D7D50_RS06075	COG2814	Major facilitator Superfamily
D7D50_RS06080	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D7D50_RS06090	COG0557	exoribonuclease II activity
D7D50_RS06110	COG1380	Effector of murein hydrolase LrgA
D7D50_RS06115	COG1346	cytolysis
D7D50_RS06130	COG0737	Belongs to the 5'-nucleotidase family
D7D50_RS06165	COG0006	proline dipeptidase activity
D7D50_RS06170	COG1609	Transcriptional regulator
D7D50_RS06180	COG0438	transferase activity, transferring glycosyl groups
D7D50_RS06185	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D7D50_RS06195	COG0745	RESPONSE REGULATOR receiver
D7D50_RS06200	COG5002	protein histidine kinase activity
D7D50_RS06205	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D7D50_RS06210	COG2832	Protein of unknown function (DUF454)
D7D50_RS06215	COG0571	ribonuclease III activity
D7D50_RS06220	COG1196	nuclear chromosome segregation
D7D50_RS06225	COG0561	phosphatase activity
D7D50_RS06230	COG0561	phosphatase activity
D7D50_RS06235	COG0552	protein localization to endoplasmic reticulum
D7D50_RS06245	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D7D50_RS06250	COG3689	TIGRFAM TIGR03943 family protein
D7D50_RS06255	COG0701	Predicted permease
D7D50_RS06260	COG2183	response to ionizing radiation
D7D50_RS06265	COG3091	SprT-like family
D7D50_RS06280	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
D7D50_RS06285	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D7D50_RS06310	COG0826	peptidase U32
D7D50_RS06320	COG4443	Transcriptional Coactivator p15 (PC4)
D7D50_RS06330	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D7D50_RS06340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D7D50_RS06350	COG1136	(ABC) transporter
D7D50_RS06355	COG0577	efflux transmembrane transporter activity
D7D50_RS06360	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D7D50_RS06370	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D7D50_RS06380	COG0772	Belongs to the SEDS family
D7D50_RS06385	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D7D50_RS06390	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D7D50_RS06405	COG2348	transferase activity, transferring amino-acyl groups
D7D50_RS06415	COG1078	dGTPase activity
D7D50_RS06430	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D7D50_RS06445	COG2884	Cell division ATP-binding protein ftsE
D7D50_RS06450	COG2177	Part of the ABC transporter FtsEX involved in
D7D50_RS06465	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D7D50_RS06465	COG1199	ATP-dependent helicase activity
D7D50_RS06475	COG0772	Belongs to the SEDS family
D7D50_RS06490	COG0187	DNA topoisomerase II activity
D7D50_RS06495	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
D7D50_RS06520	COG2706	6-phosphogluconolactonase activity
D7D50_RS06525	COG0628	permease
D7D50_RS06535	COG3527	Alpha-acetolactate decarboxylase
D7D50_RS06540	COG1293	RNA-binding protein homologous to eukaryotic snRNP
D7D50_RS06560	COG0072	phenylalanine-tRNA ligase activity
D7D50_RS06560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D7D50_RS06570	COG1476	TRANSCRIPTIONal
D7D50_RS06580	COG4152	abc transporter atp-binding protein
D7D50_RS06585	COG1668	transmembrane transport
D7D50_RS06590	COG4989	oxidoreductase activity
D7D50_RS06600	COG1132	(ABC) transporter
D7D50_RS06605	COG1132	(ABC) transporter
D7D50_RS06630	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D7D50_RS06645	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
D7D50_RS06650	COG3620	sequence-specific DNA binding
D7D50_RS06660	COG2514	catechol 2,3-dioxygenase activity
D7D50_RS06685	COG1363	Peptidase, m42
D7D50_RS06690	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D7D50_RS06695	COG0512	Glutamine amidotransferase of anthranilate synthase
D7D50_RS06710	COG0135	phosphoribosylanthranilate isomerase activity
D7D50_RS06720	COG0159	tryptophan synthase activity
D7D50_RS06725	COG4166	transmembrane transport
D7D50_RS06735	COG3118	belongs to the thioredoxin family
D7D50_RS06745	COG2936	dipeptidyl-peptidase activity
D7D50_RS06755	COG1131	(ABC) transporter
D7D50_RS06780	COG0268	Binds directly to 16S ribosomal RNA
D7D50_RS06785	COG1072	(Pantothenic acid kinase))
D7D50_RS06790	COG2813	Specifically methylates the guanine in position
D7D50_RS06800	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D7D50_RS06810	COG1744	ABC transporter substrate-binding protein PnrA-like
D7D50_RS06815	COG3845	ABC transporter
D7D50_RS06820	COG4603	Belongs to the binding-protein-dependent transport system permease family
D7D50_RS06825	COG1079	Belongs to the binding-protein-dependent transport system permease family
D7D50_RS06830	COG0726	polysaccharide deacetylase
D7D50_RS06835	COG0460	homoserine dehydrogenase
D7D50_RS06850	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D7D50_RS06855	COG3842	ATPase activity
D7D50_RS06860	COG1175	transmembrane transport
D7D50_RS06865	COG1177	transmembrane transport
D7D50_RS06880	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D7D50_RS06910	COG0463	Glycosyl transferase, family 2
D7D50_RS06920	COG1091	dTDP-4-dehydrorhamnose reductase activity
D7D50_RS06930	COG0463	Glycosyl transferase, family 2
D7D50_RS06955	COG1368	sulfuric ester hydrolase activity
D7D50_RS06975	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D7D50_RS06985	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D7D50_RS07000	COG2131	deaminase
D7D50_RS07035	COG2217	Heavy metal translocating P-type atpase
D7D50_RS07045	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D7D50_RS07050	COG0519	Catalyzes the synthesis of GMP from XMP
D7D50_RS07055	COG4109	DRTGG domain
D7D50_RS07060	COG0024	Methionine aminopeptidase
D7D50_RS07070	COG1846	Transcriptional regulator
D7D50_RS07085	COG2246	polysaccharide biosynthetic process
D7D50_RS07090	COG4708	membrane
D7D50_RS07100	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D7D50_RS07105	COG1597	lipid kinase activity
D7D50_RS07110	COG1523	belongs to the glycosyl hydrolase 13 family
D7D50_RS07115	COG1368	sulfuric ester hydrolase activity
D7D50_RS07120	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D7D50_RS07125	COG0710	3-dehydroquinate dehydratase activity
D7D50_RS07130	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D7D50_RS07135	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D7D50_RS07140	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D7D50_RS07145	COG0287	Prephenate dehydrogenase
D7D50_RS07150	COG3679	Belongs to the UPF0342 family
D7D50_RS07160	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D7D50_RS07165	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D7D50_RS07170	COG0077	Prephenate dehydratase
D7D50_RS07180	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D7D50_RS07195	COG0488	(ABC) transporter
D7D50_RS07245	COG0135	phosphoribosylanthranilate isomerase activity
D7D50_RS07255	COG2184	nucleotidyltransferase activity
D7D50_RS07260	COG0366	Alpha amylase catalytic
D7D50_RS07315	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D7D50_RS07320	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D7D50_RS07325	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D7D50_RS07345	COG3142	Participates in the control of copper homeostasis
D7D50_RS07360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D7D50_RS07365	COG1272	protein, Hemolysin III
D7D50_RS07380	COG1846	Transcriptional regulator
D7D50_RS07385	COG0436	Aminotransferase
D7D50_RS07400	COG0017	Asparaginyl-tRNA synthetase
D7D50_RS07420	COG1132	(ABC) transporter
D7D50_RS07435	COG1126	abc transporter atp-binding protein
D7D50_RS07440	COG0765	amino acid transport
D7D50_RS07460	COG1131	(ABC) transporter
D7D50_RS07505	COG1051	belongs to the nudix hydrolase family
D7D50_RS07520	COG2824	Alkylphosphonate utilization operon protein PhnA
D7D50_RS07530	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D7D50_RS07535	COG0540	Belongs to the ATCase OTCase family
D7D50_RS07540	COG0505	Belongs to the CarA family
D7D50_RS07545	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D7D50_RS07550	COG2195	Cleaves the N-terminal amino acid of tripeptides
D7D50_RS07555	COG0561	phosphatase activity
D7D50_RS07595	COG1011	Hydrolase
D7D50_RS07610	COG1837	Belongs to the UPF0109 family
D7D50_RS07640	COG1349	DNA-binding transcription factor activity
D7D50_RS07645	COG1105	Belongs to the carbohydrate kinase PfkB family
D7D50_RS07650	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D7D50_RS07650	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D7D50_RS07650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D7D50_RS07660	COG1307	EDD domain protein, DegV family
D7D50_RS07665	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D7D50_RS07670	COG0617	tRNA 3'-terminal CCA addition
D7D50_RS07675	COG0488	(ABC) transporter
D7D50_RS07685	COG1940	carbohydrate kinase activity
D7D50_RS07700	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D7D50_RS07715	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D7D50_RS07720	COG1705	Flagellar rod assembly protein muramidase FlgJ
D7D50_RS07720	COG1388	LysM domain
D7D50_RS07735	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D7D50_RS07755	COG1132	(ABC) transporter
D7D50_RS07770	COG0785	Cytochrome C biogenesis protein
D7D50_RS07775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D7D50_RS07780	COG0431	NADPH-dependent FMN reductase
D7D50_RS07780	COG3976	FMN-binding domain protein
D7D50_RS07780	COG1053	succinate dehydrogenase
D7D50_RS07805	COG2822	iron ion transport
D7D50_RS07810	COG2837	iron assimilation
D7D50_RS07815	COG0672	)-iron permease
D7D50_RS07820	COG0805	protein transport
D7D50_RS07825	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D7D50_RS07830	COG0110	maltose O-acetyltransferase activity
D7D50_RS07850	COG2233	PERMEase
D7D50_RS07855	COG0534	Mate efflux family protein
D7D50_RS07860	COG1942	4-Oxalocrotonate Tautomerase
D7D50_RS07865	COG1435	thymidine kinase activity
D7D50_RS07870	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D7D50_RS07875	COG2890	protein-(glutamine-N5) methyltransferase activity
D7D50_RS07885	COG0456	acetyltransferase
D7D50_RS07900	COG0741	lytic transglycosylase activity
D7D50_RS07925	COG2188	Transcriptional regulator
D7D50_RS07935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D7D50_RS07960	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D7D50_RS07970	COG3458	cephalosporin-C deacetylase activity
D7D50_RS07985	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D7D50_RS07995	COG0095	Lipoate-protein ligase
D7D50_RS08000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D7D50_RS08005	COG0508	dehydrogenase complex catalyzes the overall conversion of
D7D50_RS08010	COG0022	dehydrogenase e1 component
D7D50_RS08015	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D7D50_RS08050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D7D50_RS08055	COG0758	DNA mediated transformation
D7D50_RS08060	COG1940	carbohydrate kinase activity
D7D50_RS08080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D7D50_RS08085	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D7D50_RS08110	COG2759	Belongs to the formate--tetrahydrofolate ligase family
D7D50_RS08120	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D7D50_RS08125	COG4684	Psort location CytoplasmicMembrane, score
D7D50_RS08130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D7D50_RS08145	COG1194	a g-specific adenine glycosylase
D7D50_RS08150	COG0280	phosphate acetyltransferase
D7D50_RS08155	COG0564	pseudouridine synthase activity
D7D50_RS08165	COG2357	RelA SpoT domain protein
D7D50_RS08170	COG4116	CYTH
D7D50_RS08175	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D7D50_RS08180	COG1104	cysteine desulfurase activity
D7D50_RS08205	COG2003	Belongs to the UPF0758 family
D7D50_RS08215	COG3764	Sortase (surface protein transpeptidase)
D7D50_RS08220	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D7D50_RS08225	COG0039	L-malate dehydrogenase activity
D7D50_RS08235	COG0539	negative regulation of cytoplasmic translation
D7D50_RS08255	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D7D50_RS08260	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D7D50_RS08285	COG0187	DNA topoisomerase II activity
D7D50_RS08310	COG4221	oxidoreductase activity
D7D50_RS08320	COG2323	membrane
D7D50_RS08330	COG0066	3-isopropylmalate dehydratase activity
D7D50_RS08345	COG0473	3-isopropylmalate dehydrogenase activity
D7D50_RS08365	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D7D50_RS08370	COG1051	belongs to the nudix hydrolase family
D7D50_RS08395	COG0284	orotidine-5'-phosphate decarboxylase activity
D7D50_RS08400	COG0167	dihydroorotate dehydrogenase activity
D7D50_RS08405	COG0543	2 iron, 2 sulfur cluster binding
D7D50_RS08415	COG0583	DNA-binding transcription factor activity
D7D50_RS08430	COG0813	purine-nucleoside phosphorylase activity
D7D50_RS08440	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D7D50_RS08450	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D7D50_RS08455	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D7D50_RS08460	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D7D50_RS08510	COG0335	large ribosomal subunit rRNA binding
D7D50_RS08515	COG0038	chloride channel
D7D50_RS08525	COG0716	FMN binding
D7D50_RS08530	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D7D50_RS08560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D7D50_RS08560	COG0425	Belongs to the sulfur carrier protein TusA family
D7D50_RS08565	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
D7D50_RS08570	COG1573	uracil-dna glycosylase
D7D50_RS08610	COG0647	UMP catabolic process
D7D50_RS08625	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D7D50_RS08630	COG0488	(ABC) transporter
D7D50_RS08640	COG0564	pseudouridine synthase activity
D7D50_RS08645	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D7D50_RS08650	COG0583	DNA-binding transcription factor activity
D7D50_RS08655	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D7D50_RS08675	COG1104	cysteine desulfurase activity
D7D50_RS08690	COG1088	dTDP-glucose 4,6-dehydratase activity
D7D50_RS08700	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
D7D50_RS08710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D7D50_RS08715	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D7D50_RS08720	COG2384	SAM-dependent methyltransferase
D7D50_RS08725	COG0625	glutathione transferase activity
D7D50_RS08730	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D7D50_RS08750	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D7D50_RS08755	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D7D50_RS08755	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D7D50_RS08790	COG2226	methyltransferase
D7D50_RS08795	COG0300	oxidoreductase activity
D7D50_RS08810	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D7D50_RS08830	COG1074	ATP-dependent DNA helicase activity
D7D50_RS08835	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
D7D50_RS08845	COG0569	domain protein
D7D50_RS08850	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D7D50_RS08870	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D7D50_RS08885	COG1136	(ABC) transporter
D7D50_RS08885	COG0577	efflux transmembrane transporter activity
D7D50_RS08890	COG1230	cation diffusion facilitator family transporter
D7D50_RS08905	COG1174	glycine betaine transport
D7D50_RS08915	COG0366	Alpha amylase catalytic
D7D50_RS08930	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D7D50_RS08945	COG1472	Belongs to the glycosyl hydrolase 3 family
D7D50_RS08950	COG0366	Alpha amylase catalytic
D7D50_RS08955	COG0395	ABC-type sugar transport system, permease component
D7D50_RS08960	COG1175	transmembrane transport
D7D50_RS08965	COG1653	transport
D7D50_RS08970	COG3345	alpha-galactosidase
D7D50_RS08975	COG2207	Transcriptional regulator
D7D50_RS08980	COG1609	Transcriptional regulator
D7D50_RS08985	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
D7D50_RS08985	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
D7D50_RS08995	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D7D50_RS09000	COG1956	GAF domain-containing protein
D7D50_RS09015	COG0673	inositol 2-dehydrogenase activity
D7D50_RS09025	COG0726	polysaccharide deacetylase
D7D50_RS09035	COG5002	protein histidine kinase activity
D7D50_RS09040	COG0745	RESPONSE REGULATOR receiver
D7D50_RS09050	COG1268	BioY protein
D7D50_RS09060	COG0704	Plays a role in the regulation of phosphate uptake
D7D50_RS09065	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D7D50_RS09070	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D7D50_RS09075	COG0581	inorganic phosphate transmembrane transporter activity
D7D50_RS09080	COG0573	inorganic phosphate transmembrane transporter activity
D7D50_RS09085	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D7D50_RS09090	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
D7D50_RS09090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D7D50_RS09095	COG0483	inositol monophosphate 1-phosphatase activity
D7D50_RS09105	COG1393	Belongs to the ArsC family
D7D50_RS09110	COG0196	riboflavin kinase activity
D7D50_RS09115	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D7D50_RS09135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D7D50_RS09140	COG0464	growth
D7D50_RS09160	COG0210	DNA helicase
D7D50_RS09165	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D7D50_RS09170	COG0681	Belongs to the peptidase S26 family
D7D50_RS09175	COG0469	pyruvate kinase activity
D7D50_RS09210	COG1131	(ABC) transporter
D7D50_RS09215	COG2151	metal-sulfur cluster biosynthetic enzyme
D7D50_RS09220	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D7D50_RS09225	COG0358	DNA primase activity
D7D50_RS09230	COG1970	mechanosensitive ion channel activity
D7D50_RS09235	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D7D50_RS09250	COG0492	ferredoxin-NADP+ reductase activity
D7D50_RS09255	COG1481	regulation of sporulation
D7D50_RS09260	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D7D50_RS09265	COG1660	Displays ATPase and GTPase activities
D7D50_RS09270	COG0251	oxidation-reduction process
D7D50_RS09280	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D7D50_RS09290	COG4932	domain protein
D7D50_RS09295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D7D50_RS09305	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
D7D50_RS09310	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D7D50_RS09315	COG3442	glutamine amidotransferase
D7D50_RS09345	COG0488	(ABC) transporter
D7D50_RS09370	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D7D50_RS09380	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D7D50_RS09390	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D7D50_RS09395	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D7D50_RS09400	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D7D50_RS09405	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D7D50_RS09410	COG0356	it plays a direct role in the translocation of protons across the membrane
D7D50_RS09425	COG0297	glycogen (starch) synthase activity
D7D50_RS09430	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D7D50_RS09440	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D7D50_RS09455	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D7D50_RS09460	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D7D50_RS09465	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D7D50_RS09470	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D7D50_RS09480	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D7D50_RS09485	COG1061	Type III restriction enzyme res subunit
D7D50_RS09490	COG1002	Type II restriction enzyme, methylase subunits
D7D50_RS09500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D7D50_RS09505	COG4122	O-methyltransferase activity
D7D50_RS09535	COG1686	Belongs to the peptidase S11 family
D7D50_RS09555	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D7D50_RS09560	COG1438	arginine binding
D7D50_RS09575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D7D50_RS09580	COG1288	antiporter activity
D7D50_RS09585	COG0549	Belongs to the carbamate kinase family
D7D50_RS09590	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D7D50_RS09595	COG2235	arginine
D7D50_RS09610	COG0433	COG0433 Predicted ATPase
D7D50_RS09620	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D7D50_RS09625	COG1466	dna polymerase III delta subunit
D7D50_RS09635	COG0658	competence protein
D7D50_RS09635	COG2333	competence protein COMEC
D7D50_RS09640	COG1555	photosystem II stabilization
D7D50_RS09640	COG1596	polysaccharide export
D7D50_RS09645	COG0204	Acyl-transferase
D7D50_RS09650	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D7D50_RS09655	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D7D50_RS09670	COG3684	Belongs to the aldolase LacD family
D7D50_RS09675	COG1105	Belongs to the carbohydrate kinase PfkB family
D7D50_RS09680	COG0698	ribose 5-phosphate isomerase
D7D50_RS09695	COG3775	system Galactitol-specific IIC component
D7D50_RS09710	COG1349	DNA-binding transcription factor activity
D7D50_RS09715	COG0513	Belongs to the DEAD box helicase family
D7D50_RS09735	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D7D50_RS09760	COG1051	belongs to the nudix hydrolase family
D7D50_RS09765	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D7D50_RS09780	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D7D50_RS09785	COG0768	penicillin binding
D7D50_RS09790	COG0708	Exodeoxyribonuclease III
D7D50_RS09810	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D7D50_RS09820	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D7D50_RS09830	COG0494	nUDIX hydrolase
D7D50_RS09835	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D7D50_RS09990	COG0745	RESPONSE REGULATOR receiver
D7D50_RS10000	COG1028	Short-chain dehydrogenase reductase Sdr
D7D50_RS10025	COG4166	transmembrane transport
D7D50_RS10030	COG0577	efflux transmembrane transporter activity
D7D50_RS10035	COG1136	(ABC) transporter
D7D50_RS10055	COG0577	efflux transmembrane transporter activity
D7D50_RS10060	COG1136	(ABC) transporter
D7D50_RS10070	COG0745	RESPONSE REGULATOR receiver
D7D50_RS10090	COG3655	Transcriptional regulator