locus-tag	class	description
A6J68_RS00020	COG1396	sequence-specific DNA binding
A6J68_RS00070	COG1914	H( )-stimulated, divalent metal cation uptake system
A6J68_RS00080	COG1131	(ABC) transporter
A6J68_RS00090	COG1994	Peptidase M50
A6J68_RS00095	COG0535	radical SAM domain protein
A6J68_RS00165	COG1131	(ABC) transporter
A6J68_RS00175	COG1396	sequence-specific DNA binding
A6J68_RS00195	COG1694	Mazg nucleotide pyrophosphohydrolase
A6J68_RS00210	COG2897	thiosulfate sulfurtransferase activity
A6J68_RS00230	COG0371	Dehydrogenase
A6J68_RS00240	COG0646	methionine synthase
A6J68_RS00240	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A6J68_RS00245	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A6J68_RS00255	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A6J68_RS00275	COG2770	Histidine kinase
A6J68_RS00275	COG2205	protein histidine kinase activity
A6J68_RS00295	COG2814	Major facilitator Superfamily
A6J68_RS00300	COG4667	esterase of the alpha-beta hydrolase superfamily
A6J68_RS00305	COG1442	glycosyl transferase family 8
A6J68_RS00310	COG1442	glycosyl transferase family 8
A6J68_RS00335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6J68_RS00340	COG0564	pseudouridine synthase activity
A6J68_RS00360	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6J68_RS00365	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
A6J68_RS00385	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A6J68_RS00390	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A6J68_RS00390	COG1116	anion transmembrane transporter activity
A6J68_RS00400	COG0561	phosphatase activity
A6J68_RS00405	COG2514	catechol 2,3-dioxygenase activity
A6J68_RS00415	COG0602	queuosine metabolic process
A6J68_RS00435	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A6J68_RS00435	COG1328	CTP reductase activity
A6J68_RS00455	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A6J68_RS00465	COG1393	Belongs to the ArsC family
A6J68_RS00470	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A6J68_RS00475	COG1546	Belongs to the CinA family
A6J68_RS00475	COG1058	Belongs to the CinA family
A6J68_RS00480	COG2818	Glycosylase
A6J68_RS00520	COG0018	arginyl-trna synthetase
A6J68_RS00530	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6J68_RS00535	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6J68_RS00540	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A6J68_RS00545	COG0124	histidyl-tRNA synthetase
A6J68_RS00555	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6J68_RS00610	COG4974	Belongs to the 'phage' integrase family
A6J68_RS00635	COG4974	Belongs to the 'phage' integrase family
A6J68_RS00645	COG0745	RESPONSE REGULATOR receiver
A6J68_RS00650	COG5002	protein histidine kinase activity
A6J68_RS00655	COG1288	antiporter activity
A6J68_RS00665	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6J68_RS00670	COG3852	Histidine kinase
A6J68_RS00675	COG0784	Response regulator, receiver
A6J68_RS00680	COG1125	glycine betaine transport
A6J68_RS00680	COG0517	IMP dehydrogenase activity
A6J68_RS00685	COG1174	glycine betaine transport
A6J68_RS00690	COG0392	lysyltransferase activity
A6J68_RS00690	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A6J68_RS00700	COG3759	membrane
A6J68_RS00820	COG3645	SOS response
A6J68_RS00825	COG0582	viral genome integration into host DNA
A6J68_RS00840	COG0305	Participates in initiation and elongation during chromosome replication
A6J68_RS00855	COG0445	tRNA wobble uridine modification
A6J68_RS00860	COG2095	MarC family integral membrane protein
A6J68_RS00865	COG0482	sulfurtransferase activity
A6J68_RS00870	COG1760	l-serine dehydratase
A6J68_RS00875	COG1760	l-serine dehydratase
A6J68_RS00880	COG0741	lytic transglycosylase activity
A6J68_RS00905	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6J68_RS00910	COG0612	Peptidase, M16
A6J68_RS00915	COG0612	Peptidase, M16
A6J68_RS00920	COG2501	S4 domain
A6J68_RS00940	COG0516	GMP reductase activity
A6J68_RS00940	COG0517	IMP dehydrogenase activity
A6J68_RS00950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6J68_RS00995	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6J68_RS01000	COG0488	(ABC) transporter
A6J68_RS01005	COG4485	Bacterial membrane protein, YfhO
A6J68_RS01025	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A6J68_RS01030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6J68_RS01035	COG1475	DNA binding
A6J68_RS01045	COG0592	DNA-directed DNA polymerase activity
A6J68_RS01050	COG1597	lipid kinase activity
A6J68_RS01065	COG0012	GTP binding
A6J68_RS01075	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6J68_RS01085	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A6J68_RS01115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6J68_RS01300	COG0436	Aminotransferase
A6J68_RS01315	COG0416	fatty acid biosynthetic process
A6J68_RS01320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6J68_RS01325	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A6J68_RS01330	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6J68_RS01345	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6J68_RS01355	COG0138	bifunctional purine biosynthesis protein purh
A6J68_RS01380	COG1175	transmembrane transport
A6J68_RS01385	COG0395	ABC-type sugar transport system, permease component
A6J68_RS01400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6J68_RS01410	COG3458	cephalosporin-C deacetylase activity
A6J68_RS01425	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A6J68_RS01445	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6J68_RS01460	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6J68_RS01470	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A6J68_RS01470	COG2755	lipolytic protein G-D-S-L family
A6J68_RS01475	COG1012	belongs to the aldehyde dehydrogenase family
A6J68_RS01475	COG1454	alcohol dehydrogenase
A6J68_RS01480	COG1064	alcohol dehydrogenase
A6J68_RS01490	COG0534	Mate efflux family protein
A6J68_RS01600	COG0201	protein transport
A6J68_RS01605	COG0563	adenylate kinase activity
A6J68_RS01620	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A6J68_RS01630	COG0202	RNA polymerase activity
A6J68_RS01770	COG1705	Flagellar rod assembly protein muramidase FlgJ
A6J68_RS01775	COG1420	regulation of RNA biosynthetic process
A6J68_RS01785	COG0443	Heat shock 70 kDa protein
A6J68_RS01795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6J68_RS01805	COG0351	phosphomethylpyrimidine kinase
A6J68_RS01810	COG4720	Psort location CytoplasmicMembrane, score
A6J68_RS01820	COG0668	transmembrane transport
A6J68_RS01850	COG0756	dUTP diphosphatase activity
A6J68_RS01865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6J68_RS01875	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6J68_RS01880	COG1879	ABC-type sugar transport system periplasmic component
A6J68_RS01885	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J68_RS01900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6J68_RS01905	COG1609	Transcriptional regulator
A6J68_RS01915	COG0577	efflux transmembrane transporter activity
A6J68_RS01920	COG1136	(ABC) transporter
A6J68_RS01925	COG0745	RESPONSE REGULATOR receiver
A6J68_RS01930	COG5002	protein histidine kinase activity
A6J68_RS01935	COG0137	argininosuccinate synthase activity
A6J68_RS01945	COG0191	fructose-bisphosphate aldolase activity
A6J68_RS01965	COG1461	Dihydroxyacetone kinase
A6J68_RS01985	COG1126	abc transporter atp-binding protein
A6J68_RS01990	COG0765	amino acid transport
A6J68_RS02010	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6J68_RS02020	COG0719	Fe-S assembly protein
A6J68_RS02025	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6J68_RS02035	COG0719	Fe-S assembly protein
A6J68_RS02040	COG1686	Belongs to the peptidase S11 family
A6J68_RS02045	COG1686	Belongs to the peptidase S11 family
A6J68_RS02050	COG4166	transmembrane transport
A6J68_RS02055	COG0601	transmembrane transport
A6J68_RS02060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6J68_RS02065	COG0444	Belongs to the ABC transporter superfamily
A6J68_RS02070	COG4608	Belongs to the ABC transporter superfamily
A6J68_RS02115	COG1121	(ABC) transporter
A6J68_RS02120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6J68_RS02135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6J68_RS02135	COG4499	WXG100 protein secretion system (Wss), protein YukC
A6J68_RS02160	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6J68_RS02165	COG1459	type II secretion system
A6J68_RS02210	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6J68_RS02215	COG1363	Peptidase, m42
A6J68_RS02230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6J68_RS02235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J68_RS02250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6J68_RS02270	COG1346	cytolysis
A6J68_RS02285	COG0601	transmembrane transport
A6J68_RS02290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6J68_RS02295	COG1122	ATPase activity
A6J68_RS02305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J68_RS02305	COG1263	PTS System
A6J68_RS02310	COG0366	Alpha amylase catalytic
A6J68_RS02315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J68_RS02330	COG3959	Transketolase, thiamine diphosphate binding domain
A6J68_RS02335	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A6J68_RS02340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6J68_RS02350	COG1185	polyribonucleotide nucleotidyltransferase activity
A6J68_RS02360	COG1045	serine acetyltransferase
A6J68_RS02370	COG0215	cysteine-tRNA ligase activity
A6J68_RS02375	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
A6J68_RS02400	COG1476	TRANSCRIPTIONal
A6J68_RS02405	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A6J68_RS02415	COG0582	viral genome integration into host DNA
A6J68_RS02540	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6J68_RS02555	COG0791	NLP P60 protein
A6J68_RS02555	COG0741	lytic transglycosylase activity
A6J68_RS02585	COG2946	Replication initiation factor
A6J68_RS02595	COG1674	ftsk spoiiie
A6J68_RS02655	COG2814	Major facilitator Superfamily
A6J68_RS02665	COG1732	Glycine betaine
A6J68_RS02835	COG1695	Transcriptional regulator
A6J68_RS02850	COG1755	Isoprenylcysteine carboxyl methyltransferase
A6J68_RS02890	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6J68_RS02895	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6J68_RS02915	COG1131	(ABC) transporter
A6J68_RS02930	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A6J68_RS02935	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A6J68_RS02940	COG0275	rRNA processing
A6J68_RS02950	COG0768	penicillin binding
A6J68_RS02960	COG0513	Belongs to the DEAD box helicase family
A6J68_RS02975	COG1126	abc transporter atp-binding protein
A6J68_RS02985	COG0492	ferredoxin-NADP+ reductase activity
A6J68_RS02990	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A6J68_RS03000	COG3579	cysteine-type endopeptidase activity
A6J68_RS03005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6J68_RS03035	COG0116	Belongs to the methyltransferase superfamily
A6J68_RS03045	COG1854	S-ribosylhomocysteine lyase activity
A6J68_RS03050	COG1418	mRNA catabolic process
A6J68_RS03050	COG4372	Transposase
A6J68_RS03060	COG1131	(ABC) transporter
A6J68_RS03070	COG4585	Histidine kinase
A6J68_RS03075	COG2197	response regulator
A6J68_RS03085	COG0194	GDP metabolic process
A6J68_RS03095	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A6J68_RS03100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A6J68_RS03105	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6J68_RS03105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6J68_RS03115	COG2815	serine threonine protein kinase
A6J68_RS03115	COG0515	serine threonine protein kinase
A6J68_RS03125	COG4585	Histidine kinase
A6J68_RS03130	COG2197	response regulator
A6J68_RS03140	COG1098	S1 RNA binding domain
A6J68_RS03145	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6J68_RS03150	COG1349	DNA-binding transcription factor activity
A6J68_RS03160	COG1447	Phosphotransferase system cellobiose-specific component IIA
A6J68_RS03170	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6J68_RS03175	COG1882	Formate acetyltransferase
A6J68_RS03195	COG1739	Uncharacterized protein family UPF0029
A6J68_RS03200	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A6J68_RS03240	COG0527	aspartate kinase activity
A6J68_RS03245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6J68_RS03255	COG1024	Enoyl-CoA hydratase
A6J68_RS03265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6J68_RS03275	COG2070	2-Nitropropane dioxygenase
A6J68_RS03280	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A6J68_RS03285	COG1028	Short-chain dehydrogenase reductase Sdr
A6J68_RS03290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6J68_RS03305	COG0439	Biotin carboxylase
A6J68_RS03325	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A6J68_RS03340	COG3716	PTS system mannose fructose sorbose family IID component
A6J68_RS03345	COG3715	PTS system
A6J68_RS03360	COG0561	phosphatase activity
A6J68_RS03375	COG2252	PERMEase
A6J68_RS03380	COG0802	atpase or kinase
A6J68_RS03390	COG1316	TRANSCRIPTIONal
A6J68_RS03400	COG0537	adenosine 5'-monophosphoramidase activity
A6J68_RS03415	COG1131	(ABC) transporter
A6J68_RS03420	COG4473	ABC transporter
A6J68_RS03430	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6J68_RS03445	COG0195	Participates in both transcription termination and antitermination
A6J68_RS03450	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A6J68_RS03460	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A6J68_RS03465	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A6J68_RS03490	COG2860	membrane
A6J68_RS03500	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6J68_RS03500	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6J68_RS03505	COG1832	CoA-binding protein
A6J68_RS03525	COG5002	protein histidine kinase activity
A6J68_RS03545	COG1268	BioY protein
A6J68_RS03550	COG1234	tRNA 3'-trailer cleavage
A6J68_RS03565	COG0166	Belongs to the GPI family
A6J68_RS03570	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6J68_RS03575	COG0705	Rhomboid family
A6J68_RS03575	COG0457	Tetratricopeptide repeat
A6J68_RS03580	COG1744	ABC transporter substrate-binding protein PnrA-like
A6J68_RS03585	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A6J68_RS03600	COG0706	membrane insertase activity
A6J68_RS03675	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6J68_RS03685	COG2153	protein acetylation
A6J68_RS03695	COG1442	glycosyl transferase family 8
A6J68_RS03695	COG1216	Glycosyl transferase, family 2
A6J68_RS03755	COG0789	Transcriptional regulator
A6J68_RS03765	COG0656	L-ascorbic acid biosynthetic process
A6J68_RS03815	COG0582	viral genome integration into host DNA
A6J68_RS03870	COG0673	inositol 2-dehydrogenase activity
A6J68_RS03880	COG2315	Protein conserved in bacteria
A6J68_RS03895	COG0742	ribosomal rna small subunit methyltransferase
A6J68_RS03910	COG3480	Lon protease (S16) C-terminal proteolytic domain
A6J68_RS03915	COG0737	Belongs to the 5'-nucleotidase family
A6J68_RS03920	COG4470	Protein conserved in bacteria
A6J68_RS03925	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A6J68_RS03935	COG1132	(ABC) transporter
A6J68_RS03940	COG1132	(ABC) transporter
A6J68_RS03945	COG0512	Glutamine amidotransferase of anthranilate synthase
A6J68_RS03955	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6J68_RS03975	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6J68_RS03990	COG1940	carbohydrate kinase activity
A6J68_RS03995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6J68_RS04000	COG1217	gtp-binding protein TYPA
A6J68_RS04010	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6J68_RS04035	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6J68_RS04045	COG0762	integral membrane protein
A6J68_RS04050	COG2302	S4 RNA-binding domain
A6J68_RS04055	COG3599	regulation of cell shape
A6J68_RS04060	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A6J68_RS04070	COG0494	nUDIX hydrolase
A6J68_RS04075	COG0542	response to heat
A6J68_RS04085	COG4703	Protein of unknown function (DUF1797)
A6J68_RS04090	COG0765	amino acid transport
A6J68_RS04095	COG1126	abc transporter atp-binding protein
A6J68_RS04100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6J68_RS04110	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A6J68_RS04115	COG1570	exodeoxyribonuclease VII activity
A6J68_RS04120	COG1722	exodeoxyribonuclease VII activity
A6J68_RS04130	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A6J68_RS04135	COG1438	arginine binding
A6J68_RS04140	COG0497	DNA recombination
A6J68_RS04145	COG1307	EDD domain protein, DegV family
A6J68_RS04150	COG2755	lipolytic protein G-D-S-L family
A6J68_RS04165	COG0582	viral genome integration into host DNA
A6J68_RS04180	COG1396	sequence-specific DNA binding
A6J68_RS04295	COG1783	phage Terminase large subunit
A6J68_RS04450	COG1078	dGTPase activity
A6J68_RS04475	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A6J68_RS04485	COG2884	Cell division ATP-binding protein ftsE
A6J68_RS04490	COG2177	Part of the ABC transporter FtsEX involved in
A6J68_RS04520	COG1199	ATP-dependent helicase activity
A6J68_RS04520	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6J68_RS04525	COG0436	Aminotransferase
A6J68_RS04530	COG0017	Asparaginyl-tRNA synthetase
A6J68_RS04555	COG1660	Displays ATPase and GTPase activities
A6J68_RS04580	COG0254	rRNA binding
A6J68_RS04585	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A6J68_RS04590	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6J68_RS04595	COG0716	FMN binding
A6J68_RS04600	COG1605	Chorismate mutase
A6J68_RS04600	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A6J68_RS04605	COG0038	chloride channel
A6J68_RS04610	COG0335	large ribosomal subunit rRNA binding
A6J68_RS04660	COG1136	(ABC) transporter
A6J68_RS04675	COG5002	protein histidine kinase activity
A6J68_RS04695	COG0772	Belongs to the SEDS family
A6J68_RS04715	COG0560	Phosphoserine phosphatase
A6J68_RS04730	COG0148	phosphopyruvate hydratase activity
A6J68_RS04750	COG1316	TRANSCRIPTIONal
A6J68_RS04765	COG3700	Belongs to the class B bacterial acid phosphatase family
A6J68_RS04875	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A6J68_RS04910	COG1028	Short-chain dehydrogenase reductase Sdr
A6J68_RS04915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6J68_RS04920	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6J68_RS04940	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A6J68_RS04945	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6J68_RS04965	COG3064	Membrane
A6J68_RS04965	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6J68_RS04980	COG3590	peptidase
A6J68_RS04985	COG3590	peptidase
A6J68_RS05025	COG1136	(ABC) transporter
A6J68_RS05040	COG0586	Pfam SNARE associated Golgi protein
A6J68_RS05045	COG4619	ABC transporter
A6J68_RS05050	COG0390	transport system, permease component
A6J68_RS05060	COG0583	DNA-binding transcription factor activity
A6J68_RS05075	COG2211	Major facilitator Superfamily
A6J68_RS05085	COG3250	beta-galactosidase activity
A6J68_RS05090	COG2186	Transcriptional regulator
A6J68_RS05100	COG0800	Aldolase
A6J68_RS05115	COG1028	Short-chain dehydrogenase reductase Sdr
A6J68_RS05135	COG1609	Transcriptional regulator
A6J68_RS05150	COG0438	transferase activity, transferring glycosyl groups
A6J68_RS05175	COG0765	amino acid transport
A6J68_RS05180	COG0765	amino acid transport
A6J68_RS05185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J68_RS05190	COG1126	abc transporter atp-binding protein
A6J68_RS05195	COG0745	RESPONSE REGULATOR receiver
A6J68_RS05200	COG5002	protein histidine kinase activity
A6J68_RS05205	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A6J68_RS05210	COG2832	Protein of unknown function (DUF454)
A6J68_RS05220	COG1196	nuclear chromosome segregation
A6J68_RS05225	COG0561	phosphatase activity
A6J68_RS05230	COG0561	phosphatase activity
A6J68_RS05235	COG0552	protein localization to endoplasmic reticulum
A6J68_RS05245	COG3689	TIGRFAM TIGR03943 family protein
A6J68_RS05250	COG0701	Predicted permease
A6J68_RS05265	COG2183	response to ionizing radiation
A6J68_RS05270	COG3091	SprT-like family
A6J68_RS05275	COG1983	PspC domain protein
A6J68_RS05315	COG0826	peptidase U32
A6J68_RS05320	COG4443	Transcriptional Coactivator p15 (PC4)
A6J68_RS05330	COG1914	H( )-stimulated, divalent metal cation uptake system
A6J68_RS05370	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A6J68_RS05395	COG1164	Oligoendopeptidase f
A6J68_RS05405	COG0772	Belongs to the SEDS family
A6J68_RS05425	COG0768	penicillin binding
A6J68_RS05440	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6J68_RS05445	COG2223	nitrite transmembrane transporter activity
A6J68_RS05470	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6J68_RS05475	COG2011	ABC-type metal ion transport system permease component
A6J68_RS05480	COG1464	Belongs to the NlpA lipoprotein family
A6J68_RS05485	COG0513	Belongs to the DEAD box helicase family
A6J68_RS05495	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A6J68_RS05500	COG0204	Acyl-transferase
A6J68_RS05505	COG1596	polysaccharide export
A6J68_RS05505	COG1555	photosystem II stabilization
A6J68_RS05510	COG0658	competence protein
A6J68_RS05510	COG2333	competence protein COMEC
A6J68_RS05515	COG0561	phosphatase activity
A6J68_RS05520	COG1609	Transcriptional regulator
A6J68_RS05525	COG0657	acetylesterase activity
A6J68_RS05530	COG2226	methyltransferase
A6J68_RS05540	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A6J68_RS05545	COG3711	transcriptional antiterminator
A6J68_RS05550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J68_RS05550	COG1263	PTS System
A6J68_RS05550	COG2190	(PTS) system
A6J68_RS05560	COG3835	regulator
A6J68_RS05565	COG1929	Belongs to the glycerate kinase type-1 family
A6J68_RS05570	COG2610	gluconate transmembrane transporter activity
A6J68_RS05580	COG1846	Transcriptional regulator
A6J68_RS05585	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A6J68_RS05595	COG0363	glucosamine-6-phosphate deaminase activity
A6J68_RS05600	COG0435	Glutathione S-transferase
A6J68_RS05605	COG1187	pseudouridine synthase activity
A6J68_RS05630	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6J68_RS05635	COG4122	O-methyltransferase activity
A6J68_RS05640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6J68_RS05645	COG4894	glucomannan catabolic process
A6J68_RS05650	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6J68_RS05660	COG1442	glycosyl transferase family 8
A6J68_RS05675	COG1476	TRANSCRIPTIONal
A6J68_RS05690	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6J68_RS05695	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6J68_RS05700	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6J68_RS05720	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A6J68_RS05735	COG0488	(ABC) transporter
A6J68_RS05770	COG1012	belongs to the aldehyde dehydrogenase family
A6J68_RS05775	COG0726	polysaccharide deacetylase
A6J68_RS05780	COG0513	Belongs to the DEAD box helicase family
A6J68_RS05790	COG1956	GAF domain-containing protein
A6J68_RS05795	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A6J68_RS05805	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A6J68_RS05805	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A6J68_RS05835	COG4721	ABC-type cobalt transport system, permease component
A6J68_RS05840	COG1122	ATPase activity
A6J68_RS05850	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A6J68_RS05870	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6J68_RS05880	COG4109	DRTGG domain
A6J68_RS05885	COG0024	Methionine aminopeptidase
A6J68_RS05895	COG2246	polysaccharide biosynthetic process
A6J68_RS05900	COG4708	membrane
A6J68_RS05905	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6J68_RS05910	COG1597	lipid kinase activity
A6J68_RS05915	COG1523	belongs to the glycosyl hydrolase 13 family
A6J68_RS05975	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6J68_RS05985	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6J68_RS06010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J68_RS06010	COG0072	phenylalanine-tRNA ligase activity
A6J68_RS06015	COG2321	neutral zinc metallopeptidase
A6J68_RS06020	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A6J68_RS06025	COG1074	ATP-dependent DNA helicase activity
A6J68_RS06035	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A6J68_RS06040	COG0488	(ABC) transporter
A6J68_RS06045	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A6J68_RS06050	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6J68_RS06050	COG0022	dehydrogenase e1 component
A6J68_RS06055	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6J68_RS06065	COG0095	Lipoate-protein ligase
A6J68_RS06080	COG3442	glutamine amidotransferase
A6J68_RS06085	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6J68_RS06090	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A6J68_RS06115	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6J68_RS06125	COG0647	UMP catabolic process
A6J68_RS06135	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
A6J68_RS06140	COG1518	maintenance of DNA repeat elements
A6J68_RS06145	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
A6J68_RS06160	COG0481	GTPase activity
A6J68_RS06170	COG1418	mRNA catabolic process
A6J68_RS06175	COG0456	acetyltransferase
A6J68_RS06185	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A6J68_RS06215	COG1131	(ABC) transporter
A6J68_RS06220	COG1725	Transcriptional regulator
A6J68_RS06230	COG0205	6-phosphofructokinase activity
A6J68_RS06235	COG0469	pyruvate kinase activity
A6J68_RS06250	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6J68_RS06255	COG2824	Alkylphosphonate utilization operon protein PhnA
A6J68_RS06260	COG0765	amino acid transport
A6J68_RS06265	COG1126	abc transporter atp-binding protein
A6J68_RS06280	COG1072	(Pantothenic acid kinase))
A6J68_RS06285	COG2813	Specifically methylates the guanine in position
A6J68_RS06295	COG1744	ABC transporter substrate-binding protein PnrA-like
A6J68_RS06300	COG3845	ABC transporter
A6J68_RS06305	COG4603	Belongs to the binding-protein-dependent transport system permease family
A6J68_RS06310	COG1079	Belongs to the binding-protein-dependent transport system permease family
A6J68_RS06330	COG3764	Sortase (surface protein transpeptidase)
A6J68_RS06335	COG0346	lactoylglutathione lyase activity
A6J68_RS06355	COG2188	Transcriptional regulator
A6J68_RS06370	COG1464	Belongs to the NlpA lipoprotein family
A6J68_RS06385	COG1136	(ABC) transporter
A6J68_RS06395	COG0745	RESPONSE REGULATOR receiver
A6J68_RS06400	COG5002	protein histidine kinase activity
A6J68_RS06405	COG4974	Belongs to the 'phage' integrase family
A6J68_RS06410	COG4166	transmembrane transport
A6J68_RS06425	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6J68_RS06430	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
A6J68_RS06435	COG5002	protein histidine kinase activity
A6J68_RS06440	COG0745	RESPONSE REGULATOR receiver
A6J68_RS06450	COG0704	Plays a role in the regulation of phosphate uptake
A6J68_RS06455	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6J68_RS06460	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6J68_RS06465	COG0581	inorganic phosphate transmembrane transporter activity
A6J68_RS06470	COG0573	inorganic phosphate transmembrane transporter activity
A6J68_RS06480	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A6J68_RS06480	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6J68_RS06485	COG0483	inositol monophosphate 1-phosphatase activity
A6J68_RS06490	COG4476	Belongs to the UPF0223 family
A6J68_RS06500	COG0196	riboflavin kinase activity
A6J68_RS06505	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6J68_RS06535	COG1136	(ABC) transporter
A6J68_RS06540	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6J68_RS06545	COG0758	DNA mediated transformation
A6J68_RS06550	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A6J68_RS06555	COG4604	ABC transporter, ATP-binding protein
A6J68_RS06560	COG4605	iron ion homeostasis
A6J68_RS06565	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J68_RS06570	COG0110	maltose O-acetyltransferase activity
A6J68_RS06580	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A6J68_RS06585	COG1376	ErfK ybiS ycfS ynhG family protein
A6J68_RS06590	COG1966	Carbon starvation protein
A6J68_RS06595	COG3279	Response regulator of the LytR AlgR family
A6J68_RS06600	COG3275	phosphorelay sensor kinase activity
A6J68_RS06700	COG0505	Belongs to the CarA family
A6J68_RS06715	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A6J68_RS06730	COG0488	(ABC) transporter
A6J68_RS06740	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6J68_RS06755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6J68_RS06795	COG0095	Lipoate-protein ligase
A6J68_RS06805	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6J68_RS06810	COG4684	Psort location CytoplasmicMembrane, score
A6J68_RS06815	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6J68_RS06825	COG1132	(ABC) transporter
A6J68_RS06855	COG2890	protein-(glutamine-N5) methyltransferase activity
A6J68_RS06860	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A6J68_RS06870	COG1942	4-Oxalocrotonate Tautomerase
A6J68_RS06890	COG0431	NADPH-dependent FMN reductase
A6J68_RS06890	COG1053	succinate dehydrogenase
A6J68_RS06890	COG3976	FMN-binding domain protein
A6J68_RS06900	COG2233	PERMEase
A6J68_RS06915	COG0477	Major facilitator Superfamily
A6J68_RS06935	COG0280	phosphate acetyltransferase
A6J68_RS06940	COG0564	pseudouridine synthase activity
A6J68_RS06950	COG2357	RelA SpoT domain protein
A6J68_RS06965	COG1104	cysteine desulfurase activity
A6J68_RS06975	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A6J68_RS06980	COG2003	Belongs to the UPF0758 family
A6J68_RS06985	COG0628	permease
A6J68_RS06990	COG2723	6-phospho-beta-galactosidase activity
A6J68_RS07000	COG0561	phosphatase activity
A6J68_RS07020	COG1388	LysM domain
A6J68_RS07020	COG0860	N-Acetylmuramoyl-L-alanine amidase
A6J68_RS07085	COG0740	serine-type endopeptidase activity
A6J68_RS07090	COG4695	Portal protein
A6J68_RS07130	COG0270	DNA (cytosine-5-)-methyltransferase activity
A6J68_RS07195	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6J68_RS07195	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6J68_RS07245	COG4372	Transposase
A6J68_RS07295	COG0038	chloride channel
A6J68_RS07305	COG1177	transmembrane transport
A6J68_RS07310	COG1176	ABC-type spermidine putrescine transport system, permease component I
A6J68_RS07320	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6J68_RS07345	COG0285	dihydrofolate synthase activity
A6J68_RS07350	COG2962	Rard protein
A6J68_RS07365	COG0726	polysaccharide deacetylase
A6J68_RS07380	COG1012	belongs to the aldehyde dehydrogenase family
A6J68_RS07455	COG2261	transglycosylase associated protein
A6J68_RS07480	COG1115	amino acid carrier protein
A6J68_RS07485	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A6J68_RS07490	COG1380	Effector of murein hydrolase LrgA
A6J68_RS07495	COG1346	cytolysis
A6J68_RS07510	COG0539	negative regulation of cytoplasmic translation
A6J68_RS07530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6J68_RS07540	COG0187	DNA topoisomerase II activity
A6J68_RS07545	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A6J68_RS07550	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A6J68_RS07560	COG2755	lipolytic protein G-D-S-L family
A6J68_RS07560	COG1083	cytidylyl-transferase
A6J68_RS07575	COG2089	acid synthase
A6J68_RS07590	COG1216	Glycosyl transferase, family 2
A6J68_RS07590	COG1442	glycosyl transferase family 8
A6J68_RS07595	COG1216	Glycosyl transferase, family 2
A6J68_RS07595	COG1442	glycosyl transferase family 8
A6J68_RS07610	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A6J68_RS07615	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6J68_RS07635	COG1316	TRANSCRIPTIONal
A6J68_RS07670	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A6J68_RS07705	COG3842	ATPase activity
A6J68_RS07720	COG1293	RNA-binding protein homologous to eukaryotic snRNP
A6J68_RS07725	COG3527	Alpha-acetolactate decarboxylase
A6J68_RS07730	COG0028	Belongs to the TPP enzyme family
A6J68_RS07735	COG0457	Tetratricopeptide repeat
A6J68_RS07740	COG0628	permease
A6J68_RS07750	COG1051	belongs to the nudix hydrolase family
A6J68_RS07755	COG5492	domain, Protein
A6J68_RS07760	COG1088	dTDP-glucose 4,6-dehydratase activity
A6J68_RS07770	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A6J68_RS07775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6J68_RS07785	COG2384	SAM-dependent methyltransferase
A6J68_RS07810	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A6J68_RS07810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A6J68_RS07815	COG0300	oxidoreductase activity
A6J68_RS07830	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6J68_RS07835	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6J68_RS07860	COG1573	uracil-dna glycosylase
A6J68_RS07865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6J68_RS07875	COG0584	glycerophosphoryl diester phosphodiesterase
A6J68_RS07900	COG0534	Mate efflux family protein
A6J68_RS07940	COG0803	Belongs to the bacterial solute-binding protein 9 family
A6J68_RS08020	COG0515	serine threonine protein kinase
A6J68_RS08055	COG2040	homocysteine
A6J68_RS08060	COG0833	amino acid
A6J68_RS08100	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A6J68_RS08110	COG3425	synthase
A6J68_RS08125	COG1272	protein, Hemolysin III
A6J68_RS08170	COG0745	RESPONSE REGULATOR receiver
A6J68_RS08175	COG2357	RelA SpoT domain protein
A6J68_RS08180	COG1132	(ABC) transporter
A6J68_RS08195	COG0737	Belongs to the 5'-nucleotidase family
A6J68_RS08200	COG0242	peptide deformylase activity
A6J68_RS08205	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A6J68_RS08215	COG1132	(ABC) transporter
A6J68_RS08230	COG0488	(ABC) transporter
A6J68_RS08260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J68_RS08260	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6J68_RS08260	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6J68_RS08265	COG1105	Belongs to the carbohydrate kinase PfkB family
A6J68_RS08270	COG1349	DNA-binding transcription factor activity
A6J68_RS08325	COG1837	Belongs to the UPF0109 family
A6J68_RS08330	COG0228	four-way junction DNA binding
A6J68_RS08335	COG0577	efflux transmembrane transporter activity
A6J68_RS08340	COG1136	(ABC) transporter
A6J68_RS08345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J68_RS08350	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A6J68_RS08355	COG0505	Belongs to the CarA family
A6J68_RS08365	COG0564	pseudouridine synthase activity
A6J68_RS08375	COG0583	DNA-binding transcription factor activity
A6J68_RS08380	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A6J68_RS08405	COG1104	cysteine desulfurase activity
A6J68_RS08415	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6J68_RS08420	COG1442	glycosyl transferase family 8
A6J68_RS08440	COG0653	protein targeting
A6J68_RS08450	COG1073	alpha beta
A6J68_RS08490	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6J68_RS08495	COG1368	sulfuric ester hydrolase activity
A6J68_RS08500	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A6J68_RS08510	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A6J68_RS08540	COG2244	polysaccharide biosynthetic process
A6J68_RS08545	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6J68_RS08550	COG1120	ATPase activity
A6J68_RS08555	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A6J68_RS08560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J68_RS08565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J68_RS08580	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6J68_RS08585	COG1253	flavin adenine dinucleotide binding
A6J68_RS08595	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A6J68_RS08600	COG1242	4 iron, 4 sulfur cluster binding
A6J68_RS08605	COG0671	phosphoesterase, PA-phosphatase related
A6J68_RS08610	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A6J68_RS08640	COG0681	Belongs to the peptidase S26 family
A6J68_RS08650	COG0297	glycogen (starch) synthase activity
A6J68_RS08690	COG3475	LICD family
A6J68_RS08705	COG0463	Glycosyl transferase, family 2
A6J68_RS08710	COG1215	transferase activity, transferring glycosyl groups
A6J68_RS08720	COG1091	dTDP-4-dehydrorhamnose reductase activity
A6J68_RS08725	COG2151	metal-sulfur cluster biosynthetic enzyme
A6J68_RS08730	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6J68_RS08735	COG0358	DNA primase activity
A6J68_RS08740	COG1970	mechanosensitive ion channel activity
A6J68_RS08765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J68_RS08770	COG0004	ammonium transporteR
A6J68_RS08780	COG1054	Belongs to the UPF0176 family
A6J68_RS08790	COG2271	Major facilitator Superfamily
A6J68_RS08800	COG0058	SHG alpha-glucan phosphorylase activity
A6J68_RS08805	COG1640	4-alpha-glucanotransferase
A6J68_RS08810	COG1609	Transcriptional regulator
A6J68_RS08820	COG1175	transmembrane transport
A6J68_RS08825	COG3833	ABC-type maltose transport systems, permease component
A6J68_RS08830	COG3104	oligopeptide transport
A6J68_RS08870	COG0765	amino acid transport
A6J68_RS08875	COG1126	abc transporter atp-binding protein
A6J68_RS08900	COG2309	aminopeptidase activity
A6J68_RS08920	COG1187	pseudouridine synthase activity
A6J68_RS08925	COG0656	L-ascorbic acid biosynthetic process
A6J68_RS08930	COG0778	Nitroreductase
A6J68_RS08935	COG0346	lactoylglutathione lyase activity
A6J68_RS08940	COG0463	Glycosyl transferase, family 2
A6J68_RS08945	COG1113	amino acid transport
A6J68_RS08950	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A6J68_RS08955	COG0557	exoribonuclease II activity
A6J68_RS08970	COG2814	Major facilitator Superfamily
A6J68_RS08980	COG1131	(ABC) transporter
A6J68_RS08990	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A6J68_RS08995	COG1396	sequence-specific DNA binding
A6J68_RS09050	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A6J68_RS09055	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A6J68_RS09085	COG1702	phosphate starvation-inducible protein PhoH
A6J68_RS09110	COG0233	cytoplasmic translational termination
A6J68_RS09125	COG0444	Belongs to the ABC transporter superfamily
A6J68_RS09130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6J68_RS09135	COG0601	transmembrane transport
A6J68_RS09140	COG0747	negative chemotaxis
A6J68_RS09145	COG0081	regulation of translation
A6J68_RS09165	COG1473	amidohydrolase
A6J68_RS09170	COG0583	DNA-binding transcription factor activity
A6J68_RS09190	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6J68_RS09195	COG1674	ftsk spoiiie
A6J68_RS09200	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6J68_RS09225	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6J68_RS09260	COG0673	inositol 2-dehydrogenase activity
A6J68_RS09275	COG1028	Short-chain dehydrogenase reductase Sdr
A6J68_RS09325	COG1114	Component of the transport system for branched-chain amino acids
A6J68_RS09330	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J68_RS09330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J68_RS09350	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6J68_RS09360	COG0708	Exodeoxyribonuclease III
A6J68_RS09365	COG1393	Belongs to the ArsC family
A6J68_RS09370	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6J68_RS09385	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A6J68_RS09415	COG0470	DNA polymerase III
A6J68_RS09430	COG0517	IMP dehydrogenase activity
A6J68_RS09450	COG0559	Belongs to the binding-protein-dependent transport system permease family
A6J68_RS09470	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A6J68_RS09475	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A6J68_RS09485	COG0531	amino acid
A6J68_RS09490	COG0569	domain protein
A6J68_RS09495	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6J68_RS09505	COG1187	pseudouridine synthase activity
A6J68_RS09555	COG1827	regulation of RNA biosynthetic process
A6J68_RS09570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6J68_RS09575	COG1254	Belongs to the acylphosphatase family
A6J68_RS09585	COG0765	amino acid transport
A6J68_RS09590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J68_RS09605	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6J68_RS09640	COG1484	DNA-dependent DNA replication
A6J68_RS09655	COG5002	protein histidine kinase activity
A6J68_RS09660	COG0745	RESPONSE REGULATOR receiver
A6J68_RS09675	COG1704	LemA family
A6J68_RS09680	COG0357	Ribosomal RNA small subunit methyltransferase G
A6J68_RS09685	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6J68_RS09690	COG0569	domain protein
A6J68_RS09715	COG1114	Component of the transport system for branched-chain amino acids
A6J68_RS09720	COG1063	alcohol dehydrogenase
A6J68_RS09745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J68_RS09750	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A6J68_RS09760	COG0217	transcriptional regulatory protein
A6J68_RS09795	COG2376	Dihydroxyacetone kinase
A6J68_RS09800	COG1309	transcriptional regulator
A6J68_RS09810	COG2376	Dihydroxyacetone kinase
A6J68_RS09815	COG1461	Dihydroxyacetone kinase
A6J68_RS09820	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
A6J68_RS09825	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6J68_RS09850	COG2226	methyltransferase
A6J68_RS09855	COG0799	negative regulation of ribosome biogenesis
A6J68_RS09865	COG1713	HD superfamily hydrolase involved in NAD metabolism
A6J68_RS09870	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A6J68_RS09875	COG1534	Rna-binding protein
A6J68_RS09880	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A6J68_RS09885	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A6J68_RS09910	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6J68_RS09910	COG0574	Belongs to the PEP-utilizing enzyme family
A6J68_RS09920	COG0517	IMP dehydrogenase activity
A6J68_RS09930	COG1335	isochorismatase
A6J68_RS09935	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A6J68_RS09940	COG0436	Aminotransferase
A6J68_RS09945	COG0589	response to stress
A6J68_RS09950	COG0561	phosphatase activity
A6J68_RS09955	COG0252	asparaginase activity
A6J68_RS09965	COG4989	oxidoreductase activity
A6J68_RS09970	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6J68_RS09975	COG1705	Flagellar rod assembly protein muramidase FlgJ
A6J68_RS09975	COG3942	CHAP domain
A6J68_RS09985	COG0736	holo-[acyl-carrier-protein] synthase activity
A6J68_RS09990	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6J68_RS10000	COG1482	cell wall glycoprotein biosynthetic process
A6J68_RS10005	COG1940	carbohydrate kinase activity
A6J68_RS10010	COG1263	PTS System
A6J68_RS10010	COG2190	(PTS) system
A6J68_RS10010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J68_RS10015	COG1621	beta-fructofuranosidase activity
A6J68_RS10020	COG1609	Transcriptional regulator
A6J68_RS10025	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6J68_RS10035	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6J68_RS10085	COG2131	deaminase
A6J68_RS10090	COG0006	proline dipeptidase activity
A6J68_RS10100	COG2814	Major facilitator Superfamily
A6J68_RS10130	COG0629	single-stranded DNA binding
A6J68_RS10135	COG0360	Binds together with S18 to 16S ribosomal RNA
A6J68_RS10140	COG1194	a g-specific adenine glycosylase
A6J68_RS10150	COG3118	belongs to the thioredoxin family
A6J68_RS10180	COG0681	Belongs to the peptidase S26 family
A6J68_RS10185	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6J68_RS10200	COG1882	Formate acetyltransferase
A6J68_RS10210	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A6J68_RS10225	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6J68_RS10235	COG2814	Major facilitator Superfamily
A6J68_RS10240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6J68_RS10255	COG0142	geranyltranstransferase activity
A6J68_RS10260	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A6J68_RS10265	COG4988	ABC transporter
A6J68_RS10270	COG1294	oxidase, subunit
A6J68_RS10275	COG1271	oxidase subunit
A6J68_RS10280	COG1252	NADH dehydrogenase
A6J68_RS10305	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A6J68_RS10310	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6J68_RS10330	COG2081	HI0933 family
A6J68_RS10360	COG0456	acetyltransferase
A6J68_RS10365	COG1214	PFAM Peptidase M22, glycoprotease
A6J68_RS10380	COG3942	CHAP domain
A6J68_RS10385	COG0174	glutamine synthetase
A6J68_RS10390	COG0789	Transcriptional regulator
A6J68_RS10405	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A6J68_RS10435	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6J68_RS10485	COG0084	hydrolase, TatD family'
A6J68_RS10510	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A6J68_RS10515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6J68_RS10520	COG1696	Membrane protein involved in D-alanine export
A6J68_RS10540	COG0745	RESPONSE REGULATOR receiver
A6J68_RS10550	COG3314	Sporulation integral membrane protein YlbJ
A6J68_RS10565	COG4175	Glycine betaine
A6J68_RS10565	COG3448	diguanylate cyclase activity
A6J68_RS10575	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
A6J68_RS10595	COG1070	Carbohydrate kinase
A6J68_RS10605	COG3775	system Galactitol-specific IIC component
A6J68_RS10610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6J68_RS10620	COG1609	Transcriptional regulator
A6J68_RS10670	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A6J68_RS10705	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6J68_RS10710	COG1428	Deoxynucleoside kinase
A6J68_RS10720	COG0542	response to heat
A6J68_RS10725	COG4463	regulation of RNA biosynthetic process
A6J68_RS10735	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A6J68_RS10745	COG0450	alkyl hydroperoxide reductase
A6J68_RS10760	COG0025	NhaP-type Na H and K H
A6J68_RS10770	COG1619	proteins homologs of microcin C7 resistance protein MccF
A6J68_RS10775	COG3590	peptidase
A6J68_RS10805	COG1609	Transcriptional regulator
A6J68_RS10815	COG3716	PTS system mannose fructose sorbose family IID component
A6J68_RS10820	COG3715	PTS system
A6J68_RS10825	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J68_RS10830	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A6J68_RS10845	COG1028	Short-chain dehydrogenase reductase Sdr
A6J68_RS10880	COG2176	DNA-directed DNA polymerase activity
A6J68_RS10885	COG1388	LysM domain
A6J68_RS10885	COG1705	Flagellar rod assembly protein muramidase FlgJ
A6J68_RS10900	COG4589	Belongs to the CDS family
A6J68_RS10905	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6J68_RS10910	COG1862	Preprotein translocase
A6J68_RS10930	COG3493	citrate carrier protein
A6J68_RS10935	COG3290	protein histidine kinase activity
A6J68_RS10940	COG4565	transcriptional regulatory protein
A6J68_RS10945	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6J68_RS10955	COG3842	ATPase activity
A6J68_RS11035	COG1490	D-aminoacyl-tRNA deacylase activity
A6J68_RS11045	COG0737	Belongs to the 5'-nucleotidase family
A6J68_RS11055	COG1363	Peptidase, m42
A6J68_RS11070	COG2207	Transcriptional regulator
A6J68_RS11070	COG4753	response regulator
A6J68_RS11075	COG2972	Histidine kinase
A6J68_RS11080	COG3716	PTS system mannose fructose sorbose family IID component
A6J68_RS11085	COG3715	PTS system
A6J68_RS11115	COG1131	(ABC) transporter
A6J68_RS11130	COG3290	protein histidine kinase activity
A6J68_RS11135	COG3279	Response regulator of the LytR AlgR family
A6J68_RS11150	COG2190	(PTS) system
A6J68_RS11150	COG1263	PTS System
A6J68_RS11150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J68_RS11155	COG5002	protein histidine kinase activity
A6J68_RS11160	COG0745	RESPONSE REGULATOR receiver
A6J68_RS11170	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6J68_RS11175	COG0581	inorganic phosphate transmembrane transporter activity
A6J68_RS11180	COG0573	inorganic phosphate transmembrane transporter activity
A6J68_RS11195	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6J68_RS11210	COG0789	Transcriptional regulator
A6J68_RS11235	COG0456	acetyltransferase
A6J68_RS11240	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6J68_RS11255	COG0582	viral genome integration into host DNA
A6J68_RS11295	COG0433	COG0433 Predicted ATPase
A6J68_RS11315	COG4115	mRNA cleavage
A6J68_RS11350	COG3620	sequence-specific DNA binding
A6J68_RS11365	COG1674	ftsk spoiiie