locus-tag class description HW271_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HW271_RS00020 ENOG4105C3G gtp-binding protein HW271_RS00030 ENOG4108JA2 transcriptioN-repair coupling factor HW271_RS00035 ENOG41082I2 s4 domain protein HW271_RS00055 ENOG4108UGV hypoxanthine phosphoribosyltransferase HW271_RS00060 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HW271_RS00115 ENOG4107Z0P This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HW271_RS00130 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HW271_RS00145 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HW271_RS00160 ENOG4105K4P CoA-binding domain protein HW271_RS00165 ENOG4105HMI Membrane HW271_RS00170 ENOG4105CHM Aminotransferase HW271_RS00175 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) HW271_RS00185 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HW271_RS00195 ENOG4107QIK phosphoribosylformylglycinamidine synthase HW271_RS00210 ENOG4108V3E phosphoribosylglycinamide formyltransferase HW271_RS00225 ENOG4105C12 Phosphoribosylglycinamide synthetase HW271_RS00230 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HW271_RS00235 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HW271_RS00250 ENOG4105C83 adenylosuccinate lyase HW271_RS00255 ENOG41069UX Beta-N-acetyl-hexosaminidase HW271_RS00260 ENOG4105FDP GntR family transcriptional regulator HW271_RS00270 ENOG4108IQ3 PTS system HW271_RS00275 ENOG4105ETZ PTS System HW271_RS00280 ENOG4105F3R pts system mannose fructose sorbose family iid HW271_RS00290 ENOG4105E70 isomerase HW271_RS00295 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HW271_RS00315 ENOG41072GX Peptidase M22 Glycoprotease HW271_RS00360 ENOG4105D01 (LipO)protein HW271_RS00365 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HW271_RS00370 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HW271_RS00385 ENOG4105CUT histidyl-tRNA synthetase HW271_RS00390 ENOG4108M1Z surface protein HW271_RS00395 ENOG4105CKK Glycosyl transferase, family 2 HW271_RS00405 ENOG4105VZ8 Transcriptional regulator HW271_RS00440 ENOG4107AYK membrAne HW271_RS00445 ENOG4105FKQ transcriptional regulator HW271_RS00450 ENOG4108VP7 maltodextrose utilization protein MalA HW271_RS00455 ENOG4105EG2 ABC transporter, permease HW271_RS00460 ENOG4105D56 permease protein HW271_RS00465 ENOG4107FKK extracellular solute-binding protein family 1 HW271_RS00470 ENOG4107SBB 4-alpha-glucanotransferase (EC 2.4.1.25) HW271_RS00475 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HW271_RS00480 ENOG4105DHI Methyltransferase HW271_RS00500 ENOG4108R3E Dna-3-methyladenine glycosylase i HW271_RS00530 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HW271_RS00535 ENOG4105DC7 peptidase M24 HW271_RS00545 ENOG410888K transcriptional regulator, Spx HW271_RS00570 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HW271_RS00580 ENOG4108KP7 hydrolase HW271_RS00585 ENOG4105C7N Xanthine uracil vitamin C permease HW271_RS00590 ENOG4105K8N protein family UPF0079, ATPase HW271_RS00600 ENOG4108KGH TRANSCRIPTIONal HW271_RS00620 ENOG4105UQX Mate efflux family protein HW271_RS00625 ENOG4105CDY transcriptional regulatory protein HW271_RS00645 ENOG4105BZ1 (ABC) transporter HW271_RS00665 ENOG4105VB9 50S ribosomal protein l28 HW271_RS00675 ENOG4105DP4 dak2 domain fusion protein ylov HW271_RS00690 ENOG4108M15 ABC transporter HW271_RS00695 ENOG4105KCT ABC transporter HW271_RS00700 ENOG4105BZU Histidine kinase HW271_RS00735 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HW271_RS00740 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HW271_RS00755 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HW271_RS00760 ENOG4105KNE Phosphatidate cytidylyltransferase HW271_RS00765 ENOG4105DZP Membrane-associated zinc metalloprotease HW271_RS00775 ENOG4105CS2 ec 3.2.1.21 HW271_RS00785 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HW271_RS00800 ENOG4108UZ3 Transporter HW271_RS00805 ENOG4105BZ4 penicillin-binding protein HW271_RS00810 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HW271_RS00825 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HW271_RS00875 ENOG4105CF7 AraC family transcriptional regulator HW271_RS00880 ENOG4105FCD Major Facilitator HW271_RS00895 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HW271_RS00910 ENOG4105CTZ aminopeptidase c HW271_RS00935 ENOG4105F3R pts system mannose fructose sorbose family iid HW271_RS00940 ENOG4105ETZ PTS System HW271_RS00955 ENOG4105D98 threonine synthase HW271_RS00960 ENOG4105UQX Mate efflux family protein HW271_RS00965 ENOG4107XGZ Hydrolase HW271_RS00985 ENOG4105KA3 membrAne HW271_RS01010 ENOG4105VG1 fes assembly suf system protein HW271_RS01035 ENOG4105C2F Histidine kinase HW271_RS01040 ENOG4107VQW regulatoR HW271_RS01050 ENOG4105MTF NrdI protein HW271_RS01070 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HW271_RS01105 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HW271_RS01120 ENOG4105C88 aminopeptidase HW271_RS01180 ENOG4105D1H recombination factor protein RarA HW271_RS01195 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HW271_RS01205 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HW271_RS01210 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HW271_RS01220 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HW271_RS01225 ENOG4105K63 Thioredoxin HW271_RS01245 ENOG41067MG lrgb family HW271_RS01255 ENOG4105CZV ABC transporter HW271_RS01260 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HW271_RS01305 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HW271_RS01310 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HW271_RS01325 ENOG4105CB5 ATP-dependent DNA helicase recG HW271_RS01330 ENOG4105I82 acetyl xylan esterase HW271_RS01335 ENOG4108478 ec 3.2.1.18 HW271_RS01350 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HW271_RS01355 ENOG4105DRS transport system, permease HW271_RS01360 ENOG4105XEP YhcH YjgK YiaL family protein HW271_RS01395 ENOG4107RF6 penicillin-binding protein HW271_RS01410 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) HW271_RS01425 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HW271_RS01430 ENOG4108UJD 30S ribosomal protein S9 HW271_RS01510 ENOG4105DZR Type I site-specific deoxyribonuclease HW271_RS01555 ENOG4107PBV potassium channel HW271_RS01595 ENOG4105MZU cell filamentation protein HW271_RS01635 ENOG41067QW Transcriptional regulator HW271_RS01640 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HW271_RS01660 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HW271_RS01675 ENOG4105CG3 alpha amylase, catalytic region HW271_RS01680 ENOG4105DIB Oligopeptide-binding protein HW271_RS01685 ENOG4105DIB Oligopeptide-binding protein HW271_RS01695 ENOG4108RB3 Capsular polysaccharide biosynthesis protein HW271_RS01700 ENOG4105HTX biosynthesis protein HW271_RS01705 ENOG4105D75 Capsular exopolysaccharide family HW271_RS01710 ENOG4105D3Q Sugar transferase HW271_RS01725 ENOG4105KPE licD family HW271_RS01730 ENOG4105CG5 Glycosyl transferase (Group 1 HW271_RS01750 ENOG4105MEV Acyl-transferase HW271_RS01755 ENOG4105D5D udp-galactopyranose mutase HW271_RS01765 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HW271_RS01770 ENOG4105DFA alanine racemase domain protein HW271_RS01790 ENOG4105MMF Cell division protein DIVIVA HW271_RS01795 ENOG4105MMF Cell division protein DIVIVA HW271_RS01800 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HW271_RS01810 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HW271_RS01950 ENOG4105K56 Transcriptional regulator HW271_RS01965 ENOG4105E90 ABC transporter HW271_RS01985 ENOG4105PGM cation diffusion facilitator family transporter HW271_RS01990 ENOG4105CPQ Dehydrogenase HW271_RS01995 ENOG4105CQ4 Transcriptional regulator HW271_RS02000 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HW271_RS02005 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase HW271_RS02020 ENOG4105CGK Exodeoxyribonuclease III HW271_RS02025 ENOG4105BZ1 (ABC) transporter HW271_RS02030 ENOG4105BZ1 (ABC) transporter HW271_RS02035 ENOG4105D3Q Sugar transferase HW271_RS02040 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HW271_RS02045 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HW271_RS02050 ENOG4105CRQ synthase (Component I) HW271_RS02055 ENOG4105DDQ anthranilate synthase HW271_RS02085 ENOG4106A3R peptidase HW271_RS02100 ENOG4105DWF phosphomethylpyrimidine kinase HW271_RS02105 ENOG4105PUK Membrane HW271_RS02140 ENOG4105CI3 gtp-binding protein typa HW271_RS02150 ENOG4105MYU Immunoglobulin A1 protease HW271_RS02160 ENOG4105D8X mechanosensitive ion channel HW271_RS02170 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase HW271_RS02175 ENOG4105CQW ribosome biogenesis GTPase YqeH HW271_RS02180 ENOG410812S Rna-binding protein HW271_RS02185 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HW271_RS02190 ENOG4108WF2 Metal Dependent Phosphohydrolase HW271_RS02195 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HW271_RS02200 ENOG4105DXX methyltransferase HW271_RS02205 ENOG4105CDE UPF0348 protein HW271_RS02215 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HW271_RS02220 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) HW271_RS02225 ENOG4105C25 Primosomal protein n' HW271_RS02235 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HW271_RS02240 ENOG4108ZF3 Phosphatase HW271_RS02245 ENOG4105D9P serine threonine protein kinase HW271_RS02260 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase HW271_RS02270 ENOG4105ETE Transcriptional regulator (LacI family HW271_RS02280 ENOG4105C5Y PTS System HW271_RS02285 ENOG4105EVU fructokinase HW271_RS02295 ENOG4105CKK Glycosyl transferase, family 2 HW271_RS02310 ENOG4107YDN peptide deformylase HW271_RS02320 ENOG4105D6E homoserine dehydrogenase HW271_RS02330 ENOG4105E0X reductase HW271_RS02345 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HW271_RS02355 ENOG4105CAK Cell division ATP-binding protein ftsE HW271_RS02360 ENOG4105CRP Part of the ABC transporter FtsEX involved in HW271_RS02405 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HW271_RS02410 ENOG4105SYT Methylenetetrahydrofolate reductase HW271_RS02420 ENOG4105D7W serine acetyltransferase HW271_RS02430 ENOG4105C8N cysteinyl-tRNA synthetase HW271_RS02435 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) HW271_RS02445 ENOG4108IJ9 (ABC) transporter HW271_RS02465 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HW271_RS02475 ENOG4105CC5 ABC transporter HW271_RS02480 ENOG4105DIK (ABC) transporter HW271_RS02485 ENOG4105C9K Endothelin-converting enzyme 1 HW271_RS02500 ENOG4105CJZ response regulator HW271_RS02515 ENOG4105C22 threonyL-tRNA synthetase HW271_RS02530 ENOG4105EHG Permease protein HW271_RS02545 ENOG4108SA1 esterase HW271_RS02550 ENOG4105C1J atp-dependent rna helicase HW271_RS02565 ENOG41067QW Transcriptional regulator HW271_RS02620 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HW271_RS02625 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HW271_RS02630 ENOG4107IN1 Protein of unknown function (DUF1797) HW271_RS02635 ENOG4105E5Q amino acid AbC transporter HW271_RS02640 ENOG4105CDA abc transporter atp-binding protein HW271_RS02645 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HW271_RS02650 ENOG4105CNT hydrolase family 2 HW271_RS02655 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HW271_RS02665 ENOG4105DVT helicase HW271_RS02675 ENOG4108Z0Z intracellular protease Pfpi family HW271_RS02685 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HW271_RS02695 ENOG4108ZJ4 polysaccharide deacetylase HW271_RS02705 ENOG4105VJV 50s ribosomal protein L35 HW271_RS02735 ENOG4105CA9 Pyruvate kinase HW271_RS02745 ENOG4105F6E Acyl-transferase HW271_RS02750 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HW271_RS02760 ENOG4105EGD dinuclear metal center protein, YbgI family HW271_RS02765 ENOG4107VFR oxidoreductase HW271_RS02770 ENOG4105CMR udp-glucose 4-epimerase HW271_RS02790 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HW271_RS02805 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HW271_RS02810 ENOG4108UT2 hemolysin iii HW271_RS02825 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HW271_RS02830 ENOG41080E8 Transcriptional regulator, Spx MgsR family HW271_RS02835 ENOG4105E5Q amino acid AbC transporter HW271_RS02840 ENOG4105CDA abc transporter atp-binding protein HW271_RS02850 ENOG4105C3M thioredoxin reductase HW271_RS02855 ENOG4105C2N RNA methyltransferase TrmH family group 3 HW271_RS02870 ENOG4108HCJ Hydrolase HW271_RS02885 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HW271_RS02895 ENOG4105E98 transcriptional regulator DeoR family HW271_RS02900 ENOG4105DE4 1-phosphofructokinase HW271_RS02905 ENOG4105DM4 PTS System HW271_RS02930 ENOG4105CMR udp-glucose 4-epimerase HW271_RS02950 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HW271_RS02965 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HW271_RS02970 ENOG4108UT2 hemolysin iii HW271_RS02985 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HW271_RS02990 ENOG41080E8 Transcriptional regulator, Spx MgsR family HW271_RS02995 ENOG4105E5Q amino acid AbC transporter HW271_RS03000 ENOG4105CDA abc transporter atp-binding protein HW271_RS03010 ENOG4105C3M thioredoxin reductase HW271_RS03015 ENOG4105C2N RNA methyltransferase TrmH family group 3 HW271_RS03030 ENOG4108HCJ Hydrolase HW271_RS03045 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HW271_RS03055 ENOG4105E98 transcriptional regulator DeoR family HW271_RS03060 ENOG4105DE4 1-phosphofructokinase HW271_RS03065 ENOG4105DM4 PTS System HW271_RS03070 ENOG4105CNU cell division protein FtsK HW271_RS03075 ENOG4105ESP cell wall surface anchor family protein HW271_RS03090 ENOG4105C3J Cysteine desulfurase HW271_RS03115 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HW271_RS03120 ENOG4105MMD transcriptional regulator HW271_RS03125 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HW271_RS03135 ENOG4105C5H ABC transporter HW271_RS03155 ENOG410667J hydrolase HW271_RS03160 ENOG4105E98 transcriptional regulator DeoR family HW271_RS03185 ENOG4105VB6 UPF0109 protein HW271_RS03205 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HW271_RS03215 ENOG4105VEM Conserved domain protein HW271_RS03220 ENOG4105VKD bioY protein HW271_RS03225 ENOG4105DC8 reductase HW271_RS03230 ENOG4107X8C Efflux transporter RND family MFP subunit HW271_RS03235 ENOG4105C19 ABC transporter HW271_RS03240 ENOG4107RBB ABC transporter, permease HW271_RS03245 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HW271_RS03250 ENOG4107RGM aldo keto reductase HW271_RS03265 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HW271_RS03385 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HW271_RS03400 ENOG4108STX response regulator HW271_RS03405 ENOG4105US7 Histidine kinase HW271_RS03420 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HW271_RS03445 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HW271_RS03450 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HW271_RS03455 ENOG4106QP8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HW271_RS03475 ENOG4107Y49 methyltransferase HW271_RS03480 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HW271_RS03490 ENOG4105KG3 cytidine deaminase HW271_RS03495 ENOG4105DIH basic membrane HW271_RS03500 ENOG4108JQ9 ABC transporter HW271_RS03505 ENOG4105UIB (ABC) transporter HW271_RS03520 ENOG4105E5Q amino acid AbC transporter HW271_RS03525 ENOG4105CDA abc transporter atp-binding protein HW271_RS03535 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HW271_RS03550 ENOG41075D4 Aminoglycoside 6-adenylyltransferase HW271_RS03555 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HW271_RS03560 ENOG4105CM2 brancheD-chain amino acid aminotransferase HW271_RS03565 ENOG4105DIB Oligopeptide-binding protein HW271_RS03600 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HW271_RS03605 ENOG4108ZGC gaf domain protein HW271_RS03610 ENOG4105C6E dna polymerase iii HW271_RS03625 ENOG4105JRK feS assembly protein SufD HW271_RS03635 ENOG4108UNV SUF system FeS assembly protein, NifU family HW271_RS03640 ENOG4105DIW FeS assembly protein SUFB HW271_RS03650 ENOG4105CUB amino acid HW271_RS03660 ENOG4105C02 permease HW271_RS03665 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HW271_RS03675 ENOG4105FA2 dna polymerase iii HW271_RS03685 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HW271_RS03695 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HW271_RS03705 ENOG4105QNR S1 RNA binding domain protein HW271_RS03715 ENOG4105C9A Phoh family HW271_RS03720 ENOG4105DCF alanine dehydrogenase HW271_RS03725 ENOG41068WN HW271_RS03730 ENOG4105KQC Competence protein HW271_RS03740 ENOG4105CFP Peptidase U32 HW271_RS03750 ENOG4105ZA1 atp synthase HW271_RS03755 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) HW271_RS03760 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) HW271_RS03790 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HW271_RS03805 ENOG4108RCR degv family HW271_RS03810 ENOG4105K70 DNA-binding protein HW271_RS03820 ENOG4105SFS phosphoesterase RecJ domain protein HW271_RS03830 ENOG4105CQC Prephenate dehydratase HW271_RS03840 ENOG4106A8V Protein CrcB homolog HW271_RS03865 ENOG4105WKZ CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) HW271_RS03880 ENOG4105DCI Phosphohydrolase HW271_RS03895 ENOG4105EE0 oxidoreductase HW271_RS03935 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HW271_RS03940 ENOG4107QIV Cytochrome c biogenesis protein HW271_RS03945 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HW271_RS03950 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HW271_RS03955 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HW271_RS03960 ENOG4108Z6X (sortase) family HW271_RS03965 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HW271_RS03975 ENOG4105C79 DNA protecting protein DprA HW271_RS03980 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HW271_RS03985 ENOG4105WD1 Membrane HW271_RS03990 ENOG4106N3A copper homeostasis protein cutc HW271_RS04005 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HW271_RS04020 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HW271_RS04040 ENOG4105C2W permease HW271_RS04050 ENOG4108IUM Glycogen debranching enzyme HW271_RS04055 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HW271_RS04075 ENOG4105EAC phosphoserine phosphatase HW271_RS04080 ENOG4105BZW Glycerate kinase HW271_RS04110 ENOG4105DX0 Hemolysin A HW271_RS04115 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HW271_RS04120 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HW271_RS04125 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HW271_RS04150 ENOG4105DT3 PTS system, galactitol-specific IIc component HW271_RS04175 ENOG4105D2M Aldolase HW271_RS04185 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HW271_RS04195 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HW271_RS04200 ENOG4105KRI phosphocarrier protein (HPr HW271_RS04205 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HW271_RS04215 ENOG4105FH5 Membrane HW271_RS04220 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HW271_RS04245 ENOG4108Z66 YbaK ebsC protein HW271_RS04260 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HW271_RS04265 ENOG4108YZ4 nudix hydrolase HW271_RS04275 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HW271_RS04280 ENOG4105C4R Atp-dependent dna helicase HW271_RS04290 ENOG410667J hydrolase HW271_RS04340 ENOG4105IEH endo-beta-N-acetylglucosaminidase HW271_RS04370 ENOG4108Z4K mutator MutT protein HW271_RS04375 ENOG4105CD3 dihydroorotase HW271_RS04380 ENOG4107QMU Mate efflux family protein HW271_RS04385 ENOG4107RUY (E1 component), alpha subunit HW271_RS04390 ENOG4105CPP Dehydrogenase, E1 component HW271_RS04395 ENOG4105C7S Dehydrogenase HW271_RS04405 ENOG4105DF9 Lipoate-protein, ligase HW271_RS04450 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) HW271_RS04455 ENOG4108IJ2 phosphate acetyltransferase HW271_RS04460 ENOG4105EMS pseudouridine synthase HW271_RS04480 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HW271_RS04485 ENOG4105C3J Cysteine desulfurase HW271_RS04530 ENOG4105C19 ABC transporter HW271_RS04550 ENOG4108PJD permease HW271_RS04555 ENOG4108NNR transporter substrate-binding protein HW271_RS04580 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HW271_RS04585 ENOG4105CXN decarboxylase HW271_RS04620 ENOG4106611 bacteriocin immunity HW271_RS04660 ENOG4106ZEE Diacylglycerol kinase HW271_RS04715 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase HW271_RS04770 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HW271_RS04780 ENOG41065S2 pneumococcal vaccine antigen HW271_RS04805 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HW271_RS04815 ENOG4107104 thymidine kinase HW271_RS04820 ENOG41069HH 4-oxalocrotonate tautomerase HW271_RS04825 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HW271_RS04835 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HW271_RS04845 ENOG4105DSE periplasmic solute binding protein HW271_RS04855 ENOG4105DTN riboflavin biosynthesis protein ribF HW271_RS04860 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) HW271_RS04865 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) HW271_RS04880 ENOG4108KN0 Choline kinase HW271_RS04885 ENOG4105EJJ Dehydrogenase HW271_RS04900 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HW271_RS04905 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HW271_RS04915 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HW271_RS04950 ENOG410807C QueT transporter HW271_RS04960 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HW271_RS04970 ENOG4105C5H ABC transporter HW271_RS04985 ENOG4105Q2H domain protein HW271_RS04995 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HW271_RS05000 ENOG4105CEN a g-specific adenine glycosylase HW271_RS05025 ENOG4105FM1 phage shock protein C HW271_RS05030 ENOG4105BZF Glycosyl transferase (Group 1 HW271_RS05035 ENOG4105W2C Glycosyl transferase HW271_RS05040 ENOG4105VG1 fes assembly suf system protein HW271_RS05045 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HW271_RS05050 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HW271_RS05075 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HW271_RS05080 ENOG4105CNI cell division protein FtsW HW271_RS05110 ENOG41088CC tellurite resistance protein tehB HW271_RS05120 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HW271_RS05130 ENOG410861F 50S ribosomal protein L33 HW271_RS05135 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HW271_RS05140 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HW271_RS05150 ENOG4107YR5 Diacylglycerol kinase HW271_RS05165 ENOG4108JYZ YitT family HW271_RS05210 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HW271_RS05215 ENOG4108VZM 50s ribosomal protein L10 HW271_RS05220 ENOG4105RNB HW271_RS05250 ENOG4105E5Q amino acid AbC transporter HW271_RS05255 ENOG4105CDA abc transporter atp-binding protein HW271_RS05260 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HW271_RS05265 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HW271_RS05270 ENOG410667J hydrolase HW271_RS05275 ENOG4108HCJ Hydrolase HW271_RS05285 ENOG4105EN6 Membrane HW271_RS05290 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HW271_RS05305 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HW271_RS05310 ENOG4105C34 Pseudouridine synthase HW271_RS05315 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HW271_RS05325 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HW271_RS05335 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) HW271_RS05340 ENOG4105D82 Glutamate dehydrogenase HW271_RS05365 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HW271_RS05380 ENOG4108HM4 ABC transporter HW271_RS05390 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HW271_RS05395 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HW271_RS05410 ENOG4107FQX Alpha-acetolactate decarboxylase HW271_RS05420 ENOG4106PMH Extracellular solute-binding protein family 3 HW271_RS05430 ENOG4108UTW Plays a role in the regulation of phosphate uptake HW271_RS05435 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HW271_RS05440 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HW271_RS05445 ENOG4105E2Z phosphate ABC transporter (Permease HW271_RS05450 ENOG4105C8U phosphate abc transporter HW271_RS05455 ENOG4105CVA phosphate HW271_RS05460 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HW271_RS05465 ENOG4105ECY inositol monophosphatase HW271_RS05475 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) HW271_RS05485 ENOG4105D4U had-superfamily hydrolase, subfamily iia HW271_RS05495 ENOG4105CSA Coproporphyrinogen iii oxidase HW271_RS05525 ENOG4105VCC 30S ribosomal protein S21 HW271_RS05535 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HW271_RS05550 ENOG4107PMM dextranase HW271_RS05565 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HW271_RS05580 ENOG4105CSM endonuclease III HW271_RS05595 ENOG4105C5H ABC transporter HW271_RS05600 ENOG4105D0M Protease HtpX homolog HW271_RS05605 ENOG4108V0P LemA family HW271_RS05625 ENOG4108UZ3 Transporter HW271_RS05630 ENOG4107QK9 Beta-lactamase HW271_RS05645 ENOG4105CI1 PTS System HW271_RS05650 ENOG4105N5T Radical SAM Protein HW271_RS05665 ENOG4105EEQ Na H antiporter HW271_RS05690 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HW271_RS05720 ENOG4108IUW ABC transporter HW271_RS05750 ENOG4105D2N Aldolase HW271_RS05755 ENOG4105BZU Histidine kinase HW271_RS05760 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HW271_RS05765 ENOG4107WD8 ABC transporter, permease HW271_RS05775 ENOG4107WD8 ABC transporter, permease HW271_RS05790 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) HW271_RS05795 ENOG4105C1J atp-dependent rna helicase HW271_RS05800 ENOG4107QN2 dihydrolipoyl dehydrogenase HW271_RS05805 ENOG4105DMS mur ligase HW271_RS05810 ENOG4105F1K Glutamine amidotransferase HW271_RS05815 ENOG4105DC7 peptidase M24 HW271_RS05830 ENOG4105DAP Nicotinate phosphoribosyltransferase HW271_RS05845 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HW271_RS05855 ENOG4105C85 amino acid HW271_RS05860 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HW271_RS05890 ENOG4105C0D helicase HW271_RS05895 ENOG4105C87 Aminotransferase class I and II HW271_RS05900 ENOG4105C28 cystathionine HW271_RS05905 ENOG4105DIB Oligopeptide-binding protein HW271_RS05915 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HW271_RS05935 ENOG4105VC4 domain protein HW271_RS05940 ENOG41060K3 Methyltransferase HW271_RS05945 ENOG41060GV RNA binding s1 domain protein HW271_RS05960 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HW271_RS05965 ENOG4108UUM single-stranded DNA-binding protein HW271_RS05970 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HW271_RS05975 ENOG41080XP Cbs domain HW271_RS05980 ENOG4108IV0 ABC, transporter HW271_RS05985 ENOG4105C0Z ABC transporter HW271_RS05990 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HW271_RS05995 ENOG4105C32 Amino acid ABC transporter (Permease) HW271_RS06010 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HW271_RS06015 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HW271_RS06020 ENOG4108UK2 deaminase HW271_RS06030 ENOG4108S8M degv family HW271_RS06035 ENOG4105CBX hi0933 family HW271_RS06045 ENOG4105DG6 mannose-6-phosphate isomerase HW271_RS06055 ENOG4105C7K acetolactate synthase HW271_RS06060 ENOG4105C59 p-type ATPase HW271_RS06085 ENOG4105U2C Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) HW271_RS06110 ENOG4105CNT hydrolase family 2 HW271_RS06120 ENOG4108IUK alpha amylase, catalytic HW271_RS06125 ENOG4105VZ8 Transcriptional regulator HW271_RS06135 ENOG4108IXY short-chain dehydrogenase reductase HW271_RS06145 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase HW271_RS06150 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HW271_RS06170 ENOG4105DKQ ROK family HW271_RS06180 ENOG4105CRQ synthase (Component I) HW271_RS06185 ENOG4105E0X reductase HW271_RS06190 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HW271_RS06225 ENOG4105KPE licD family HW271_RS06235 ENOG4105KPE licD family HW271_RS06240 ENOG4108RCF TRANSCRIPTIONal HW271_RS06245 ENOG4105CQC Prephenate dehydratase HW271_RS06250 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HW271_RS06265 ENOG4105EVN Prephenate dehydrogenase HW271_RS06290 ENOG4105DR4 Methyltransferase HW271_RS06310 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HW271_RS06320 ENOG4105C5H ABC transporter HW271_RS06325 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HW271_RS06335 ENOG4105EPR degv family HW271_RS06360 ENOG4105CAY ferredoxin--nadp reductase HW271_RS06370 ENOG4105CHW UPF0052 protein HW271_RS06380 ENOG4105KME endoribonuclease L-psp HW271_RS06400 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HW271_RS06420 ENOG4105CP7 Triose-phosphate isomerase HW271_RS06425 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HW271_RS06440 ENOG4105WPN DNA integration recombination invertion protein HW271_RS06450 ENOG4105C5S asparaginyl-tRNA synthetase HW271_RS06455 ENOG4105CHM Aminotransferase HW271_RS06475 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HW271_RS06490 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HW271_RS06500 ENOG4105RHA ABC transporter, permease HW271_RS06505 ENOG4108IUX (ABC) transporter HW271_RS06510 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HW271_RS06530 ENOG4105DER m42 family HW271_RS06540 ENOG4105CWM branched-chain amino acid transport system II carrier protein HW271_RS06550 ENOG4108RG0 uracil-dna glycosylase HW271_RS06620 ENOG4105C3F Signal peptidase i HW271_RS06625 ENOG4105C7H Helicase, RecD TraA family HW271_RS06630 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HW271_RS06635 ENOG4105WH1 Two component transcriptional regulator luxr family HW271_RS06640 ENOG4105ENE Histidine kinase HW271_RS06675 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HW271_RS06680 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HW271_RS06685 ENOG41070VT HW271_RS06690 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HW271_RS06710 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) HW271_RS06715 ENOG4105BZ4 penicillin-binding protein HW271_RS06720 ENOG4105DIB Oligopeptide-binding protein HW271_RS06735 ENOG4105C6N Formate acetyltransferase HW271_RS06740 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HW271_RS06755 ENOG4105E5Q amino acid AbC transporter HW271_RS06760 ENOG4105CDA abc transporter atp-binding protein HW271_RS06775 ENOG4105C7B Threonine dehydratase HW271_RS06780 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HW271_RS06785 ENOG4108ZP8 Acetolactate synthase small subunit HW271_RS06795 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HW271_RS06815 ENOG410841Q phosphoesterase PA-phosphatase related protein HW271_RS06820 ENOG4108SAX Membrane HW271_RS06830 ENOG4105C1A potassium transporter peripheral membrane HW271_RS06835 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HW271_RS06845 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HW271_RS06870 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HW271_RS06910 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) HW271_RS06915 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HW271_RS06935 ENOG4105CHR reductase HW271_RS06940 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HW271_RS06945 ENOG4105EA8 2-Nitropropane dioxygenase HW271_RS06960 ENOG4105NTK Transcriptional repressor Mpra HW271_RS06965 ENOG4105CGU Enoyl-CoA hydratase HW271_RS06970 ENOG4105CFH Aspartokinase HW271_RS07000 ENOG4105F3R pts system mannose fructose sorbose family iid HW271_RS07025 ENOG4105WH1 Two component transcriptional regulator luxr family HW271_RS07030 ENOG4105BZU Histidine kinase HW271_RS07045 ENOG4105EMU Dehydrogenase HW271_RS07050 ENOG4108VDD TRNA binding domain protein HW271_RS07100 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination HW271_RS07105 ENOG4105CHV Transcription elongation factor NusA HW271_RS07135 ENOG4105K59 histidine triad (HIT) protein HW271_RS07150 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HW271_RS07165 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HW271_RS07190 ENOG4105C5F glutamine synthetase HW271_RS07195 ENOG4105KV4 Transcriptional regulator HW271_RS07210 ENOG4105CJN penicillin-binding protein HW271_RS07215 ENOG41068DC Essential cell division protein (By similarity) HW271_RS07235 ENOG4107UWA esterase HW271_RS07245 ENOG41068JE domain protein HW271_RS07250 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HW271_RS07255 ENOG4108Z40 Transcriptional regulator HW271_RS07265 ENOG4107YZX Universal stress protein HW271_RS07270 ENOG4108X4Q Hydrolase HW271_RS07275 ENOG4107RB3 L-asparaginase HW271_RS07280 ENOG4105ETE Transcriptional regulator (LacI family HW271_RS07295 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HW271_RS07305 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HW271_RS07310 ENOG4105EEI dihydropteroate synthase HW271_RS07315 ENOG4105BZA Phosphoglycerate kinase HW271_RS07325 ENOG41069UX Beta-N-acetyl-hexosaminidase HW271_RS07340 ENOG4105CN9 Peptidase m42 family protein HW271_RS07350 ENOG4105FE9 pseudouridine synthase HW271_RS07380 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HW271_RS07395 ENOG4105ESP cell wall surface anchor family protein HW271_RS07405 ENOG4108JQ7 (ABC) transporter HW271_RS07410 ENOG4105C3U ABC transporter HW271_RS07415 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HW271_RS07420 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HW271_RS07425 ENOG4105DIB Oligopeptide-binding protein HW271_RS07440 ENOG4105ZT7 DNA-entry nuclease HW271_RS07450 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HW271_RS07465 ENOG41063PX domain protein HW271_RS07475 ENOG4106H78 methyltransferase HW271_RS07485 ENOG4105HFZ Membrane HW271_RS07490 ENOG4108RWN rrna methyltransferase HW271_RS07505 ENOG4105F1A Pyruvate formate-lyase HW271_RS07515 ENOG4105DFT pur operon repressor HW271_RS07520 ENOG4105EQI Metal Dependent Phosphohydrolase HW271_RS07530 ENOG4105FJ0 thiamine HW271_RS07535 ENOG4105DJV ribulose-phosphate 3-epimerase HW271_RS07540 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HW271_RS07565 ENOG4105F8V Hydrolase, tatD family HW271_RS07570 ENOG4105C0X amino acid HW271_RS07580 ENOG4105CHM Aminotransferase HW271_RS07590 ENOG4107QYV phosphohexose isomerase HW271_RS07600 ENOG4105BZ1 (ABC) transporter HW271_RS07605 ENOG4105BZ1 (ABC) transporter HW271_RS07655 ENOG4105CE4 GlcNAc 6-P deacetylase HW271_RS07800 ENOG4108YBA Histidine kinase HW271_RS07805 ENOG4108WZ2 response regulator HW271_RS07820 ENOG4105CZN Potassium uptake protein HW271_RS07840 ENOG41061M1 UPF0337 protein HW271_RS07850 ENOG4108UW5 maltose o-acetyltransferase HW271_RS07870 ENOG4105VFE sira family HW271_RS07875 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase HW271_RS07880 ENOG4105VFE sira family HW271_RS07885 ENOG4105VPX protein, conserved in bacteria HW271_RS07895 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HW271_RS07900 ENOG4105DSE periplasmic solute binding protein HW271_RS07910 ENOG4105FDK ABC transporter HW271_RS07915 ENOG41067TZ transcriptional regulator, MarR family HW271_RS07920 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD HW271_RS07930 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HW271_RS07950 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HW271_RS07960 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HW271_RS08020 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component HW271_RS08030 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HW271_RS08035 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HW271_RS08050 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HW271_RS08135 ENOG4105BZ4 penicillin-binding protein HW271_RS08140 ENOG4105EI2 Pseudouridine synthase HW271_RS08145 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HW271_RS08150 ENOG4105C0A alcohol dehydrogenase HW271_RS08165 ENOG4105VIE preprotein translocase, subunit YajC HW271_RS08170 ENOG4105CV1 Transketolase (EC 2.2.1.1) HW271_RS08185 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HW271_RS08195 ENOG4105CAG UPF0210 protein HW271_RS08200 ENOG4105VUC UPF0237 protein HW271_RS08210 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HW271_RS08215 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HW271_RS08230 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HW271_RS08240 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HW271_RS08255 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HW271_RS08275 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HW271_RS08295 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HW271_RS08305 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HW271_RS08320 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HW271_RS08335 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HW271_RS08355 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HW271_RS08370 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HW271_RS08380 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HW271_RS08385 ENOG4105M6F mutator MutT protein HW271_RS08400 ENOG4108I7Y domain protein HW271_RS08410 ENOG4105EJQ L-serine dehydratase HW271_RS08415 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HW271_RS08435 ENOG4108RYC glycosyltransferase HW271_RS08440 ENOG4105DJ2 Major Facilitator Superfamily HW271_RS08455 ENOG4105K7K Transcriptional regulator HW271_RS08475 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HW271_RS08495 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HW271_RS08515 ENOG4105C8I hydrolase, family 38 HW271_RS08525 ENOG4105CWX Alpha-1,2-mannosidase HW271_RS08530 ENOG4105E5D amino acid HW271_RS08535 ENOG4105C2M dna polymerase I HW271_RS08540 ENOG4105ZMJ n-acetylmuramoyl-l-alanine amidase HW271_RS08550 ENOG4105CDU Replicative dna helicase HW271_RS08570 ENOG41081UC Inherit from COG: Competence protein HW271_RS08580 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HW271_RS08605 ENOG4108TV1 Catalyzes the incorporation of amino acid(s) into the interchain peptide bridge of peptidoglycan, using aminoacyl-tRNA as amino acid donor (By similarity) HW271_RS08610 ENOG41068JE domain protein HW271_RS08620 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HW271_RS08625 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) HW271_RS08630 ENOG4108JJB ABC transporter HW271_RS08635 ENOG4108JJB ABC transporter HW271_RS08640 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HW271_RS08660 ENOG410848D S4 domain protein YaaA HW271_RS08670 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HW271_RS08675 ENOG4105C31 Tryptophanyl-tRNA synthetase HW271_RS08680 ENOG4105C5H ABC transporter HW271_RS08685 ENOG4105ECB domain protein HW271_RS08685 ENOG4105ECB domain protein HW271_RS08725 ENOG4105C0H protease HW271_RS08730 ENOG4105FA0 parb-like partition protein