locus-tag	class	description
HW271_RS00010	COG0592	DNA-directed DNA polymerase activity
HW271_RS00020	COG0012	GTP binding
HW271_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HW271_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HW271_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HW271_RS00115	COG0756	dUTP diphosphatase activity
HW271_RS00130	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HW271_RS00145	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HW271_RS00160	COG1832	CoA-binding protein
HW271_RS00165	COG2855	membrane
HW271_RS00170	COG0436	Aminotransferase
HW271_RS00175	COG1381	Involved in DNA repair and RecF pathway recombination
HW271_RS00185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HW271_RS00195	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HW271_RS00200	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HW271_RS00210	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HW271_RS00225	COG0151	Belongs to the GarS family
HW271_RS00230	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HW271_RS00250	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HW271_RS00255	COG3583	domain protein
HW271_RS00255	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HW271_RS00255	COG3064	Membrane
HW271_RS00270	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW271_RS00275	COG3715	PTS system
HW271_RS00280	COG3716	PTS system mannose fructose sorbose family IID component
HW271_RS00290	COG2222	sugar isomerase
HW271_RS00315	COG1214	PFAM Peptidase M22, glycoprotease
HW271_RS00355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW271_RS00360	COG1464	Belongs to the NlpA lipoprotein family
HW271_RS00365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HW271_RS00370	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HW271_RS00385	COG0124	histidyl-tRNA synthetase
HW271_RS00390	COG4932	domain protein
HW271_RS00395	COG0463	Glycosyl transferase, family 2
HW271_RS00405	COG1476	TRANSCRIPTIONal
HW271_RS00440	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW271_RS00445	COG1609	Transcriptional regulator
HW271_RS00450	COG5521	maltodextrose utilization protein MalA
HW271_RS00455	COG3833	ABC-type maltose transport systems, permease component
HW271_RS00460	COG1175	transmembrane transport
HW271_RS00465	COG2182	Extracellular solute-binding protein
HW271_RS00470	COG1640	4-alpha-glucanotransferase
HW271_RS00475	COG0058	SHG alpha-glucan phosphorylase activity
HW271_RS00480	COG2226	methyltransferase
HW271_RS00500	COG2818	Glycosylase
HW271_RS00530	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HW271_RS00535	COG0006	proline dipeptidase activity
HW271_RS00545	COG1393	Belongs to the ArsC family
HW271_RS00570	COG0285	dihydrofolate synthase activity
HW271_RS00580	COG0561	phosphatase activity
HW271_RS00585	COG2252	PERMEase
HW271_RS00590	COG0802	atpase or kinase
HW271_RS00600	COG1316	TRANSCRIPTIONal
HW271_RS00620	COG0534	Mate efflux family protein
HW271_RS00625	COG0217	transcriptional regulatory protein
HW271_RS00645	COG1132	(ABC) transporter
HW271_RS00665	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HW271_RS00675	COG1461	Dihydroxyacetone kinase
HW271_RS00690	COG1131	(ABC) transporter
HW271_RS00695	COG0842	Transport permease protein
HW271_RS00700	COG4585	Histidine kinase
HW271_RS00705	COG2197	response regulator
HW271_RS00735	COG0525	valine-tRNA ligase activity
HW271_RS00740	COG0519	Catalyzes the synthesis of GMP from XMP
HW271_RS00755	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HW271_RS00760	COG4589	Belongs to the CDS family
HW271_RS00765	COG0750	zinc metalloprotease
HW271_RS00775	COG2723	6-phospho-beta-galactosidase activity
HW271_RS00785	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HW271_RS00800	COG0697	spore germination
HW271_RS00805	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HW271_RS00810	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HW271_RS00820	COG1178	ABC-type Fe3 transport system permease component
HW271_RS00825	COG3842	ATPase activity
HW271_RS00830	COG1840	ABC-type Fe3 transport system, periplasmic component
HW271_RS00875	COG2207	Transcriptional regulator
HW271_RS00895	COG2255	four-way junction helicase activity
HW271_RS00905	COG1187	pseudouridine synthase activity
HW271_RS00910	COG3579	cysteine-type endopeptidase activity
HW271_RS00935	COG3716	PTS system mannose fructose sorbose family IID component
HW271_RS00940	COG3715	PTS system
HW271_RS00960	COG0534	Mate efflux family protein
HW271_RS00965	COG0546	phosphoglycolate phosphatase activity
HW271_RS00985	COG3759	membrane
HW271_RS01010	COG2151	metal-sulfur cluster biosynthetic enzyme
HW271_RS01025	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HW271_RS01035	COG2972	Histidine kinase
HW271_RS01040	COG2207	Transcriptional regulator
HW271_RS01040	COG4753	response regulator
HW271_RS01050	COG1780	Probably involved in ribonucleotide reductase function
HW271_RS01070	COG1438	arginine binding
HW271_RS01105	COG2176	DNA-directed DNA polymerase activity
HW271_RS01120	COG2309	aminopeptidase activity
HW271_RS01160	COG0628	permease
HW271_RS01180	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HW271_RS01195	COG1051	belongs to the nudix hydrolase family
HW271_RS01205	COG2264	protein methyltransferase activity
HW271_RS01210	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HW271_RS01220	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HW271_RS01225	COG3118	belongs to the thioredoxin family
HW271_RS01245	COG1346	cytolysis
HW271_RS01255	COG1131	(ABC) transporter
HW271_RS01260	COG1725	Transcriptional regulator
HW271_RS01275	COG1484	DNA-dependent DNA replication
HW271_RS01305	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HW271_RS01310	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HW271_RS01325	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HW271_RS01330	COG3458	cephalosporin-C deacetylase activity
HW271_RS01350	COG1175	transmembrane transport
HW271_RS01355	COG0395	ABC-type sugar transport system, permease component
HW271_RS01360	COG2731	YhcH YjgK YiaL family protein
HW271_RS01370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HW271_RS01395	COG0768	penicillin binding
HW271_RS01410	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HW271_RS01415	COG1051	belongs to the nudix hydrolase family
HW271_RS01425	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HW271_RS01430	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HW271_RS01555	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HW271_RS01575	COG2217	Heavy metal translocating P-type atpase
HW271_RS01595	COG2184	nucleotidyltransferase activity
HW271_RS01635	COG3620	sequence-specific DNA binding
HW271_RS01640	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HW271_RS01660	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HW271_RS01665	COG3711	transcriptional antiterminator
HW271_RS01675	COG0366	Alpha amylase catalytic
HW271_RS01680	COG4166	transmembrane transport
HW271_RS01685	COG4166	transmembrane transport
HW271_RS01695	COG4464	protein tyrosine phosphatase activity
HW271_RS01700	COG3944	biosynthesis protein
HW271_RS01705	COG0489	protein tyrosine kinase activity
HW271_RS01725	COG3475	LICD family
HW271_RS01730	COG0438	transferase activity, transferring glycosyl groups
HW271_RS01735	COG0463	Glycosyl transferase, family 2
HW271_RS01740	COG1216	Glycosyl transferase, family 2
HW271_RS01740	COG1442	glycosyl transferase family 8
HW271_RS01750	COG3274	enterobacterial common antigen metabolic process
HW271_RS01755	COG0562	UDP-galactopyranose mutase
HW271_RS01765	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HW271_RS01770	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HW271_RS01790	COG3599	regulation of cell shape
HW271_RS01795	COG3599	regulation of cell shape
HW271_RS01800	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HW271_RS01810	COG0588	phosphoglycerate mutase activity
HW271_RS01815	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HW271_RS01950	COG1846	Transcriptional regulator
HW271_RS01965	COG1174	glycine betaine transport
HW271_RS01985	COG1230	cation diffusion facilitator family transporter
HW271_RS01990	COG1063	alcohol dehydrogenase
HW271_RS01995	COG1609	Transcriptional regulator
HW271_RS02000	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HW271_RS02005	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HW271_RS02020	COG0708	Exodeoxyribonuclease III
HW271_RS02025	COG1132	(ABC) transporter
HW271_RS02030	COG1132	(ABC) transporter
HW271_RS02035	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HW271_RS02040	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HW271_RS02045	COG0133	tryptophan synthase activity
HW271_RS02050	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HW271_RS02055	COG0512	Glutamine amidotransferase of anthranilate synthase
HW271_RS02085	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HW271_RS02100	COG0351	phosphomethylpyrimidine kinase
HW271_RS02105	COG4720	Psort location CytoplasmicMembrane, score
HW271_RS02135	COG1187	pseudouridine synthase activity
HW271_RS02150	COG3583	domain protein
HW271_RS02160	COG0668	transmembrane transport
HW271_RS02170	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HW271_RS02175	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HW271_RS02180	COG1534	Rna-binding protein
HW271_RS02185	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HW271_RS02190	COG1713	HD superfamily hydrolase involved in NAD metabolism
HW271_RS02195	COG0799	negative regulation of ribosome biogenesis
HW271_RS02200	COG2226	methyltransferase
HW271_RS02205	COG1323	Belongs to the UPF0348 family
HW271_RS02215	COG0194	GDP metabolic process
HW271_RS02220	COG1758	RNA polymerase activity
HW271_RS02225	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HW271_RS02235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HW271_RS02235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HW271_RS02240	COG0631	protein serine/threonine phosphatase activity
HW271_RS02245	COG0515	serine threonine protein kinase
HW271_RS02245	COG2815	serine threonine protein kinase
HW271_RS02260	COG3425	synthase
HW271_RS02270	COG1609	Transcriptional regulator
HW271_RS02275	COG1621	beta-fructofuranosidase activity
HW271_RS02280	COG1263	PTS System
HW271_RS02280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW271_RS02280	COG2190	(PTS) system
HW271_RS02285	COG1940	carbohydrate kinase activity
HW271_RS02290	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HW271_RS02295	COG0463	Glycosyl transferase, family 2
HW271_RS02310	COG0242	peptide deformylase activity
HW271_RS02330	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HW271_RS02330	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HW271_RS02345	COG0402	S-adenosylhomocysteine deaminase activity
HW271_RS02355	COG2884	Cell division ATP-binding protein ftsE
HW271_RS02360	COG2177	Part of the ABC transporter FtsEX involved in
HW271_RS02405	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HW271_RS02420	COG1045	serine acetyltransferase
HW271_RS02430	COG0215	cysteine-tRNA ligase activity
HW271_RS02435	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HW271_RS02445	COG3842	ATPase activity
HW271_RS02465	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HW271_RS02485	COG3590	peptidase
HW271_RS02500	COG0745	RESPONSE REGULATOR receiver
HW271_RS02515	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HW271_RS02530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW271_RS02545	COG2819	hydrolase of the alpha beta superfamily
HW271_RS02550	COG0513	Belongs to the DEAD box helicase family
HW271_RS02565	COG3620	sequence-specific DNA binding
HW271_RS02600	COG2188	Transcriptional regulator
HW271_RS02620	COG0494	nUDIX hydrolase
HW271_RS02625	COG0542	response to heat
HW271_RS02630	COG4703	Protein of unknown function (DUF1797)
HW271_RS02635	COG0765	amino acid transport
HW271_RS02640	COG1126	abc transporter atp-binding protein
HW271_RS02645	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HW271_RS02650	COG3250	beta-galactosidase activity
HW271_RS02655	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HW271_RS02665	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HW271_RS02665	COG1199	ATP-dependent helicase activity
HW271_RS02670	COG0772	Belongs to the SEDS family
HW271_RS02675	COG0693	protein deglycase activity
HW271_RS02685	COG0187	DNA topoisomerase II activity
HW271_RS02695	COG0726	polysaccharide deacetylase
HW271_RS02705	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HW271_RS02735	COG0469	pyruvate kinase activity
HW271_RS02745	COG0204	Acyl-transferase
HW271_RS02750	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HW271_RS02755	COG2384	SAM-dependent methyltransferase
HW271_RS02760	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HW271_RS02765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW271_RS02770	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HW271_RS02790	COG2824	Alkylphosphonate utilization operon protein PhnA
HW271_RS02805	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HW271_RS02810	COG1272	protein, Hemolysin III
HW271_RS02825	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HW271_RS02830	COG1393	Belongs to the ArsC family
HW271_RS02840	COG1126	abc transporter atp-binding protein
HW271_RS02850	COG0492	ferredoxin-NADP+ reductase activity
HW271_RS02870	COG0561	phosphatase activity
HW271_RS02885	COG1914	H( )-stimulated, divalent metal cation uptake system
HW271_RS02900	COG1105	Belongs to the carbohydrate kinase PfkB family
HW271_RS02905	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW271_RS02905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW271_RS02905	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW271_RS02915	COG2384	SAM-dependent methyltransferase
HW271_RS02930	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HW271_RS02950	COG2824	Alkylphosphonate utilization operon protein PhnA
HW271_RS02965	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HW271_RS02970	COG1272	protein, Hemolysin III
HW271_RS02985	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HW271_RS02990	COG1393	Belongs to the ArsC family
HW271_RS03000	COG1126	abc transporter atp-binding protein
HW271_RS03010	COG0492	ferredoxin-NADP+ reductase activity
HW271_RS03030	COG0561	phosphatase activity
HW271_RS03045	COG1914	H( )-stimulated, divalent metal cation uptake system
HW271_RS03060	COG1105	Belongs to the carbohydrate kinase PfkB family
HW271_RS03065	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW271_RS03065	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW271_RS03065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW271_RS03070	COG0697	spore germination
HW271_RS03070	COG1674	ftsk spoiiie
HW271_RS03075	COG0366	Alpha amylase catalytic
HW271_RS03090	COG1104	cysteine desulfurase activity
HW271_RS03100	COG2382	esterase
HW271_RS03115	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HW271_RS03120	COG4470	Protein conserved in bacteria
HW271_RS03125	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HW271_RS03135	COG0488	(ABC) transporter
HW271_RS03155	COG0561	phosphatase activity
HW271_RS03160	COG1349	DNA-binding transcription factor activity
HW271_RS03205	COG1328	CTP reductase activity
HW271_RS03205	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HW271_RS03215	COG4443	Transcriptional Coactivator p15 (PC4)
HW271_RS03220	COG1268	BioY protein
HW271_RS03225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HW271_RS03230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW271_RS03235	COG1136	(ABC) transporter
HW271_RS03240	COG0577	efflux transmembrane transporter activity
HW271_RS03245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HW271_RS03245	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HW271_RS03250	COG4989	oxidoreductase activity
HW271_RS03265	COG1028	Short-chain dehydrogenase reductase Sdr
HW271_RS03400	COG0745	RESPONSE REGULATOR receiver
HW271_RS03405	COG5002	protein histidine kinase activity
HW271_RS03420	COG1136	(ABC) transporter
HW271_RS03445	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HW271_RS03450	COG0813	purine-nucleoside phosphorylase activity
HW271_RS03455	COG0563	adenylate kinase activity
HW271_RS03475	COG2813	Specifically methylates the guanine in position
HW271_RS03480	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HW271_RS03490	COG0295	cytidine deaminase activity
HW271_RS03495	COG1744	ABC transporter substrate-binding protein PnrA-like
HW271_RS03520	COG0765	amino acid transport
HW271_RS03525	COG1126	abc transporter atp-binding protein
HW271_RS03535	COG0187	DNA topoisomerase II activity
HW271_RS03555	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HW271_RS03560	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HW271_RS03565	COG4166	transmembrane transport
HW271_RS03600	COG0539	negative regulation of cytoplasmic translation
HW271_RS03605	COG1956	GAF domain-containing protein
HW271_RS03610	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HW271_RS03625	COG0719	Fe-S assembly protein
HW271_RS03630	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HW271_RS03640	COG0719	Fe-S assembly protein
HW271_RS03650	COG0531	amino acid
HW271_RS03655	COG1686	Belongs to the peptidase S11 family
HW271_RS03660	COG0628	permease
HW271_RS03675	COG0470	DNA polymerase III
HW271_RS03695	COG0528	UMP kinase activity
HW271_RS03705	COG2996	Protein conserved in bacteria
HW271_RS03715	COG1702	phosphate starvation-inducible protein PhoH
HW271_RS03720	COG0686	Belongs to the AlaDH PNT family
HW271_RS03725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW271_RS03730	COG1596	polysaccharide export
HW271_RS03730	COG1555	photosystem II stabilization
HW271_RS03755	COG0356	it plays a direct role in the translocation of protons across the membrane
HW271_RS03760	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HW271_RS03790	COG2706	6-phosphogluconolactonase activity
HW271_RS03795	COG0628	permease
HW271_RS03805	COG1307	EDD domain protein, DegV family
HW271_RS03820	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HW271_RS03825	COG0716	FMN binding
HW271_RS03830	COG0077	Prephenate dehydratase
HW271_RS03830	COG1605	Chorismate mutase
HW271_RS03835	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HW271_RS03840	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HW271_RS03860	COG1518	maintenance of DNA repeat elements
HW271_RS03880	COG1078	dGTPase activity
HW271_RS03895	COG0673	inositol 2-dehydrogenase activity
HW271_RS03920	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HW271_RS03930	COG4109	DRTGG domain
HW271_RS03935	COG0024	Methionine aminopeptidase
HW271_RS03940	COG0785	Cytochrome C biogenesis protein
HW271_RS03945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW271_RS03950	COG0039	L-malate dehydrogenase activity
HW271_RS03955	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HW271_RS03960	COG3764	Sortase (surface protein transpeptidase)
HW271_RS03965	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HW271_RS03975	COG0758	DNA mediated transformation
HW271_RS03980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HW271_RS03985	COG2832	Protein of unknown function (DUF454)
HW271_RS03990	COG3142	Participates in the control of copper homeostasis
HW271_RS04005	COG0473	3-isopropylmalate dehydrogenase activity
HW271_RS04020	COG0066	3-isopropylmalate dehydratase activity
HW271_RS04040	COG2233	PERMEase
HW271_RS04050	COG1523	belongs to the glycosyl hydrolase 13 family
HW271_RS04055	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HW271_RS04065	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HW271_RS04075	COG0560	Phosphoserine phosphatase
HW271_RS04110	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HW271_RS04115	COG1438	arginine binding
HW271_RS04120	COG0497	DNA recombination
HW271_RS04125	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HW271_RS04150	COG3775	system Galactitol-specific IIC component
HW271_RS04175	COG3684	Belongs to the aldolase LacD family
HW271_RS04185	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW271_RS04195	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HW271_RS04200	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW271_RS04215	COG4684	Psort location CytoplasmicMembrane, score
HW271_RS04220	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HW271_RS04225	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HW271_RS04245	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HW271_RS04260	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HW271_RS04265	COG0494	nUDIX hydrolase
HW271_RS04275	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HW271_RS04290	COG0561	phosphatase activity
HW271_RS04340	COG4193	domain, Protein
HW271_RS04340	COG5263	repeat protein
HW271_RS04350	COG4932	domain protein
HW271_RS04350	COG1388	LysM domain
HW271_RS04355	COG1011	Hydrolase
HW271_RS04370	COG1051	belongs to the nudix hydrolase family
HW271_RS04375	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HW271_RS04380	COG0534	Mate efflux family protein
HW271_RS04385	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HW271_RS04390	COG0022	dehydrogenase e1 component
HW271_RS04395	COG0508	dehydrogenase complex catalyzes the overall conversion of
HW271_RS04400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HW271_RS04405	COG0095	Lipoate-protein ligase
HW271_RS04450	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HW271_RS04455	COG0280	phosphate acetyltransferase
HW271_RS04460	COG0564	pseudouridine synthase activity
HW271_RS04470	COG2357	RelA SpoT domain protein
HW271_RS04480	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HW271_RS04485	COG1104	cysteine desulfurase activity
HW271_RS04505	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HW271_RS04525	COG0577	efflux transmembrane transporter activity
HW271_RS04530	COG1136	(ABC) transporter
HW271_RS04545	COG2183	response to ionizing radiation
HW271_RS04550	COG0701	Predicted permease
HW271_RS04555	COG3689	TIGRFAM TIGR03943 family protein
HW271_RS04560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HW271_RS04580	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HW271_RS04585	COG1982	Orn Lys Arg decarboxylase major
HW271_RS04620	COG3196	Protein conserved in bacteria
HW271_RS04660	COG1597	lipid kinase activity
HW271_RS04715	COG0135	phosphoribosylanthranilate isomerase activity
HW271_RS04770	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HW271_RS04780	COG0741	lytic transglycosylase activity
HW271_RS04805	COG2890	protein-(glutamine-N5) methyltransferase activity
HW271_RS04815	COG1435	thymidine kinase activity
HW271_RS04820	COG1942	4-Oxalocrotonate Tautomerase
HW271_RS04825	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HW271_RS04835	COG2195	Cleaves the N-terminal amino acid of tripeptides
HW271_RS04845	COG3443	Belongs to the bacterial solute-binding protein 9 family
HW271_RS04845	COG0803	Belongs to the bacterial solute-binding protein 9 family
HW271_RS04855	COG0196	riboflavin kinase activity
HW271_RS04860	COG0167	dihydroorotate dehydrogenase activity
HW271_RS04865	COG0543	2 iron, 2 sulfur cluster binding
HW271_RS04870	COG4750	Nucleotidyl transferase
HW271_RS04885	COG1063	alcohol dehydrogenase
HW271_RS04900	COG0584	glycerophosphoryl diester phosphodiesterase
HW271_RS04915	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HW271_RS04950	COG4708	membrane
HW271_RS04960	COG1970	mechanosensitive ion channel activity
HW271_RS04970	COG0488	(ABC) transporter
HW271_RS04975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HW271_RS04985	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HW271_RS04995	COG0745	RESPONSE REGULATOR receiver
HW271_RS05000	COG1194	a g-specific adenine glycosylase
HW271_RS05025	COG1983	PspC domain protein
HW271_RS05030	COG0438	transferase activity, transferring glycosyl groups
HW271_RS05035	COG0438	transferase activity, transferring glycosyl groups
HW271_RS05040	COG2151	metal-sulfur cluster biosynthetic enzyme
HW271_RS05045	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HW271_RS05050	COG0358	DNA primase activity
HW271_RS05075	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HW271_RS05080	COG0772	Belongs to the SEDS family
HW271_RS05090	COG4122	O-methyltransferase activity
HW271_RS05110	COG3615	Tellurite resistance protein tehB
HW271_RS05110	COG0500	methyltransferase
HW271_RS05120	COG0557	exoribonuclease II activity
HW271_RS05130	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HW271_RS05135	COG0237	dephospho-CoA kinase activity
HW271_RS05140	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HW271_RS05150	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HW271_RS05160	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HW271_RS05165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW271_RS05210	COG0222	ribosome binding
HW271_RS05215	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HW271_RS05225	COG1827	regulation of RNA biosynthetic process
HW271_RS05250	COG0765	amino acid transport
HW271_RS05255	COG1126	abc transporter atp-binding protein
HW271_RS05260	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HW271_RS05265	COG0552	protein localization to endoplasmic reticulum
HW271_RS05270	COG0561	phosphatase activity
HW271_RS05275	COG0561	phosphatase activity
HW271_RS05285	COG2860	membrane
HW271_RS05290	COG1196	nuclear chromosome segregation
HW271_RS05305	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HW271_RS05310	COG0564	pseudouridine synthase activity
HW271_RS05315	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HW271_RS05320	COG0583	DNA-binding transcription factor activity
HW271_RS05325	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HW271_RS05335	COG0167	dihydroorotate dehydrogenase activity
HW271_RS05340	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HW271_RS05365	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HW271_RS05390	COG1177	transmembrane transport
HW271_RS05395	COG3842	ATPase activity
HW271_RS05410	COG3527	Alpha-acetolactate decarboxylase
HW271_RS05415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW271_RS05420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW271_RS05430	COG0704	Plays a role in the regulation of phosphate uptake
HW271_RS05435	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HW271_RS05440	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HW271_RS05445	COG0581	inorganic phosphate transmembrane transporter activity
HW271_RS05450	COG0573	inorganic phosphate transmembrane transporter activity
HW271_RS05455	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HW271_RS05460	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HW271_RS05460	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HW271_RS05465	COG0483	inositol monophosphate 1-phosphatase activity
HW271_RS05475	COG1393	Belongs to the ArsC family
HW271_RS05485	COG0647	UMP catabolic process
HW271_RS05495	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HW271_RS05525	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HW271_RS05535	COG4106	trans-aconitate 2-methyltransferase activity
HW271_RS05565	COG0505	Belongs to the CarA family
HW271_RS05580	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HW271_RS05595	COG0488	(ABC) transporter
HW271_RS05600	COG0501	Belongs to the peptidase M48B family
HW271_RS05605	COG1704	LemA family
HW271_RS05625	COG0697	spore germination
HW271_RS05630	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HW271_RS05645	COG1263	PTS System
HW271_RS05645	COG2190	(PTS) system
HW271_RS05645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW271_RS05650	COG1242	4 iron, 4 sulfur cluster binding
HW271_RS05655	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HW271_RS05680	COG1301	dicarboxylic acid transport
HW271_RS05690	COG2247	cell wall binding repeat
HW271_RS05690	COG0860	N-Acetylmuramoyl-L-alanine amidase
HW271_RS05720	COG4555	ABC transporter
HW271_RS05745	COG0596	Alpha beta hydrolase
HW271_RS05750	COG0191	fructose-bisphosphate aldolase activity
HW271_RS05755	COG5002	protein histidine kinase activity
HW271_RS05760	COG0745	RESPONSE REGULATOR receiver
HW271_RS05765	COG0577	efflux transmembrane transporter activity
HW271_RS05770	COG1136	(ABC) transporter
HW271_RS05775	COG0577	efflux transmembrane transporter activity
HW271_RS05785	COG1335	isochorismatase
HW271_RS05790	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HW271_RS05795	COG0513	Belongs to the DEAD box helicase family
HW271_RS05800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HW271_RS05805	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HW271_RS05810	COG3442	glutamine amidotransferase
HW271_RS05815	COG0006	proline dipeptidase activity
HW271_RS05830	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HW271_RS05845	COG1011	Hydrolase
HW271_RS05855	COG1113	amino acid transport
HW271_RS05860	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HW271_RS05865	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HW271_RS05890	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HW271_RS05895	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HW271_RS05900	COG0626	cystathionine gamma-synthase activity
HW271_RS05905	COG4166	transmembrane transport
HW271_RS05910	COG2244	polysaccharide biosynthetic process
HW271_RS05915	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HW271_RS05935	COG2827	Endonuclease containing a URI domain
HW271_RS05940	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HW271_RS05945	COG1098	S1 RNA binding domain
HW271_RS05960	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HW271_RS05965	COG0629	single-stranded DNA binding
HW271_RS05970	COG0360	Binds together with S18 to 16S ribosomal RNA
HW271_RS05975	COG0517	IMP dehydrogenase activity
HW271_RS06010	COG0740	serine-type endopeptidase activity
HW271_RS06015	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HW271_RS06020	COG2131	deaminase
HW271_RS06030	COG1307	EDD domain protein, DegV family
HW271_RS06035	COG2081	HI0933 family
HW271_RS06045	COG1482	cell wall glycoprotein biosynthetic process
HW271_RS06055	COG0028	Belongs to the TPP enzyme family
HW271_RS06060	COG2217	Heavy metal translocating P-type atpase
HW271_RS06070	COG3682	Transcriptional regulator
HW271_RS06085	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HW271_RS06110	COG3250	beta-galactosidase activity
HW271_RS06125	COG1476	TRANSCRIPTIONal
HW271_RS06135	COG0300	oxidoreductase activity
HW271_RS06145	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HW271_RS06150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HW271_RS06170	COG1940	carbohydrate kinase activity
HW271_RS06180	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HW271_RS06185	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HW271_RS06185	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HW271_RS06190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW271_RS06195	COG3064	Membrane
HW271_RS06225	COG3475	LICD family
HW271_RS06230	COG1442	glycosyl transferase family 8
HW271_RS06230	COG1216	Glycosyl transferase, family 2
HW271_RS06235	COG3475	LICD family
HW271_RS06245	COG0077	Prephenate dehydratase
HW271_RS06250	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HW271_RS06260	COG3679	Belongs to the UPF0342 family
HW271_RS06265	COG0287	Prephenate dehydrogenase
HW271_RS06290	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HW271_RS06300	COG3935	DnaD domain protein
HW271_RS06310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HW271_RS06320	COG0488	(ABC) transporter
HW271_RS06325	COG0617	tRNA 3'-terminal CCA addition
HW271_RS06335	COG1307	EDD domain protein, DegV family
HW271_RS06360	COG0492	ferredoxin-NADP+ reductase activity
HW271_RS06370	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HW271_RS06380	COG0251	oxidation-reduction process
HW271_RS06400	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HW271_RS06420	COG0149	triose-phosphate isomerase activity
HW271_RS06425	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HW271_RS06450	COG0017	Asparaginyl-tRNA synthetase
HW271_RS06455	COG0436	Aminotransferase
HW271_RS06490	COG0504	CTP synthase activity
HW271_RS06500	COG1668	transmembrane transport
HW271_RS06505	COG4152	abc transporter atp-binding protein
HW271_RS06510	COG0072	phenylalanine-tRNA ligase activity
HW271_RS06510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HW271_RS06530	COG1363	Peptidase, m42
HW271_RS06540	COG1114	Component of the transport system for branched-chain amino acids
HW271_RS06550	COG1573	uracil-dna glycosylase
HW271_RS06620	COG0681	Belongs to the peptidase S26 family
HW271_RS06625	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HW271_RS06630	COG0544	peptidyl-prolyl cis-trans isomerase activity
HW271_RS06635	COG2197	response regulator
HW271_RS06640	COG4585	Histidine kinase
HW271_RS06675	COG0745	RESPONSE REGULATOR receiver
HW271_RS06680	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HW271_RS06690	COG0116	Belongs to the methyltransferase superfamily
HW271_RS06715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HW271_RS06720	COG4166	transmembrane transport
HW271_RS06735	COG1882	Formate acetyltransferase
HW271_RS06740	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HW271_RS06755	COG0765	amino acid transport
HW271_RS06760	COG1126	abc transporter atp-binding protein
HW271_RS06775	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HW271_RS06780	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HW271_RS06785	COG0440	acetolactate synthase activity
HW271_RS06790	COG0028	Belongs to the TPP enzyme family
HW271_RS06795	COG0081	regulation of translation
HW271_RS06815	COG0671	phosphoesterase, PA-phosphatase related
HW271_RS06820	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HW271_RS06830	COG0569	domain protein
HW271_RS06835	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HW271_RS06845	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HW271_RS06870	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HW271_RS06910	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HW271_RS06915	COG0439	Biotin carboxylase
HW271_RS06930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HW271_RS06935	COG1028	Short-chain dehydrogenase reductase Sdr
HW271_RS06940	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HW271_RS06950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HW271_RS06960	COG1846	Transcriptional regulator
HW271_RS06965	COG1024	Enoyl-CoA hydratase
HW271_RS06970	COG0527	aspartate kinase activity
HW271_RS07000	COG3716	PTS system mannose fructose sorbose family IID component
HW271_RS07025	COG2197	response regulator
HW271_RS07030	COG4585	Histidine kinase
HW271_RS07045	COG4221	oxidoreductase activity
HW271_RS07050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HW271_RS07055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW271_RS07100	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HW271_RS07105	COG0195	Participates in both transcription termination and antitermination
HW271_RS07130	COG1131	(ABC) transporter
HW271_RS07135	COG0537	adenosine 5'-monophosphoramidase activity
HW271_RS07150	COG0484	heat shock protein binding
HW271_RS07165	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HW271_RS07190	COG0174	glutamine synthetase
HW271_RS07195	COG0789	Transcriptional regulator
HW271_RS07210	COG0768	penicillin binding
HW271_RS07215	COG4839	cell division protein FtsL
HW271_RS07230	COG5549	protein import
HW271_RS07230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HW271_RS07245	COG3942	CHAP domain
HW271_RS07250	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HW271_RS07250	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HW271_RS07255	COG1959	2 iron, 2 sulfur cluster binding
HW271_RS07265	COG0589	response to stress
HW271_RS07270	COG0561	phosphatase activity
HW271_RS07275	COG0252	asparaginase activity
HW271_RS07280	COG1609	Transcriptional regulator
HW271_RS07295	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HW271_RS07295	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HW271_RS07305	COG0285	dihydrofolate synthase activity
HW271_RS07310	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HW271_RS07315	COG0126	phosphoglycerate kinase activity
HW271_RS07325	COG3064	Membrane
HW271_RS07325	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HW271_RS07325	COG3583	domain protein
HW271_RS07330	COG1283	sodium-dependent phosphate transmembrane transporter activity
HW271_RS07340	COG1363	Peptidase, m42
HW271_RS07350	COG1187	pseudouridine synthase activity
HW271_RS07370	COG0517	IMP dehydrogenase activity
HW271_RS07380	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HW271_RS07395	COG0366	Alpha amylase catalytic
HW271_RS07405	COG4608	Belongs to the ABC transporter superfamily
HW271_RS07410	COG0444	Belongs to the ABC transporter superfamily
HW271_RS07415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW271_RS07420	COG0601	transmembrane transport
HW271_RS07425	COG4166	transmembrane transport
HW271_RS07435	COG1253	flavin adenine dinucleotide binding
HW271_RS07450	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HW271_RS07465	COG3480	Lon protease (S16) C-terminal proteolytic domain
HW271_RS07475	COG0742	ribosomal rna small subunit methyltransferase
HW271_RS07490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HW271_RS07495	COG1254	Belongs to the acylphosphatase family
HW271_RS07505	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HW271_RS07515	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HW271_RS07520	COG3481	metal-dependent phosphohydrolase, HD sub domain
HW271_RS07530	COG1564	THIamine pyrophosphokinase
HW271_RS07540	COG1162	GTPase activity
HW271_RS07565	COG0084	hydrolase, TatD family'
HW271_RS07570	COG0531	amino acid
HW271_RS07580	COG0436	Aminotransferase
HW271_RS07590	COG0166	Belongs to the GPI family
HW271_RS07595	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HW271_RS07600	COG1132	(ABC) transporter
HW271_RS07605	COG1132	(ABC) transporter
HW271_RS07635	COG4537	Required for transformation and DNA binding
HW271_RS07640	COG1459	type II secretion system
HW271_RS07645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HW271_RS07685	COG1674	ftsk spoiiie
HW271_RS07800	COG5002	protein histidine kinase activity
HW271_RS07805	COG0745	RESPONSE REGULATOR receiver
HW271_RS07820	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HW271_RS07840	COG3237	CsbD-like
HW271_RS07850	COG0110	maltose O-acetyltransferase activity
HW271_RS07870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HW271_RS07870	COG0425	Belongs to the sulfur carrier protein TusA family
HW271_RS07875	COG0446	pyridine nucleotide-disulphide oxidoreductase
HW271_RS07880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HW271_RS07880	COG0425	Belongs to the sulfur carrier protein TusA family
HW271_RS07885	COG1937	Protein conserved in bacteria
HW271_RS07895	COG2514	catechol 2,3-dioxygenase activity
HW271_RS07900	COG0803	Belongs to the bacterial solute-binding protein 9 family
HW271_RS07900	COG3443	Belongs to the bacterial solute-binding protein 9 family
HW271_RS07905	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HW271_RS07910	COG1121	(ABC) transporter
HW271_RS07915	COG1846	Transcriptional regulator
HW271_RS07920	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HW271_RS07930	COG1696	Membrane protein involved in D-alanine export
HW271_RS07950	COG1696	Membrane protein involved in D-alanine export
HW271_RS07960	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HW271_RS07995	COG4463	regulation of RNA biosynthetic process
HW271_RS08010	COG1116	anion transmembrane transporter activity
HW271_RS08015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW271_RS08020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW271_RS08030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW271_RS08035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HW271_RS08045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW271_RS08050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HW271_RS08135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HW271_RS08140	COG0564	pseudouridine synthase activity
HW271_RS08150	COG1012	belongs to the aldehyde dehydrogenase family
HW271_RS08150	COG1454	alcohol dehydrogenase
HW271_RS08165	COG1862	Preprotein translocase
HW271_RS08170	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HW271_RS08185	COG0706	membrane insertase activity
HW271_RS08195	COG2848	UPF0210 protein
HW271_RS08200	COG3830	Belongs to the UPF0237 family
HW271_RS08210	COG0202	RNA polymerase activity
HW271_RS08215	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HW271_RS08225	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HW271_RS08230	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HW271_RS08240	COG0201	protein transport
HW271_RS08255	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HW271_RS08275	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HW271_RS08295	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HW271_RS08305	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HW271_RS08320	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HW271_RS08335	COG0088	Forms part of the polypeptide exit tunnel
HW271_RS08370	COG1328	CTP reductase activity
HW271_RS08380	COG0445	tRNA wobble uridine modification
HW271_RS08385	COG0494	nUDIX hydrolase
HW271_RS08400	COG1652	LysM domain
HW271_RS08400	COG2823	Periplasmic or secreted lipoprotein
HW271_RS08405	COG1760	l-serine dehydratase
HW271_RS08410	COG1760	l-serine dehydratase
HW271_RS08415	COG0546	phosphoglycolate phosphatase activity
HW271_RS08435	COG1216	Glycosyl transferase, family 2
HW271_RS08440	COG2807	transmembrane transport
HW271_RS08455	COG1695	Transcriptional regulator
HW271_RS08475	COG0751	glycine-tRNA ligase activity
HW271_RS08495	COG0395	ABC-type sugar transport system, permease component
HW271_RS08500	COG4209	transmembrane transport
HW271_RS08515	COG0383	alpha-mannosidase activity
HW271_RS08525	COG3537	Alpha-1,2-mannosidase
HW271_RS08530	COG0531	amino acid
HW271_RS08535	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HW271_RS08535	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HW271_RS08540	COG1388	LysM domain
HW271_RS08540	COG0860	N-Acetylmuramoyl-L-alanine amidase
HW271_RS08550	COG0305	Participates in initiation and elongation during chromosome replication
HW271_RS08570	COG1040	competence protein
HW271_RS08575	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HW271_RS08580	COG1739	Uncharacterized protein family UPF0029
HW271_RS08605	COG2348	transferase activity, transferring amino-acyl groups
HW271_RS08610	COG3942	CHAP domain
HW271_RS08620	COG1792	Involved in formation and maintenance of cell shape
HW271_RS08625	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HW271_RS08630	COG1122	ATPase activity
HW271_RS08635	COG1122	ATPase activity
HW271_RS08640	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HW271_RS08650	COG0612	Peptidase, M16
HW271_RS08660	COG2501	S4 domain
HW271_RS08670	COG0517	IMP dehydrogenase activity
HW271_RS08670	COG0516	GMP reductase activity
HW271_RS08675	COG0180	Tryptophanyl-tRNA synthetase
HW271_RS08680	COG0488	(ABC) transporter
HW271_RS08685	COG1511	domain protein
HW271_RS08685	COG1511	domain protein
HW271_RS08725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HW271_RS08730	COG1475	DNA binding