locus-tag	class	description
BKM66_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BKM66_RS00010	COG0592	DNA-directed DNA polymerase activity
BKM66_RS00030	COG0012	GTP binding
BKM66_RS00035	COG0193	aminoacyl-tRNA hydrolase activity
BKM66_RS00040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BKM66_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BKM66_RS00065	COG0037	tRNA processing
BKM66_RS00075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BKM66_RS00190	COG1792	Involved in formation and maintenance of cell shape
BKM66_RS00205	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BKM66_RS00210	COG0436	Aminotransferase
BKM66_RS00215	COG1381	Involved in DNA repair and RecF pathway recombination
BKM66_RS00220	COG0416	fatty acid biosynthetic process
BKM66_RS00225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BKM66_RS00235	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BKM66_RS00250	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BKM66_RS00260	COG0138	bifunctional purine biosynthesis protein purh
BKM66_RS00270	COG0151	Belongs to the GarS family
BKM66_RS00275	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BKM66_RS00290	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BKM66_RS00310	COG1131	(ABC) transporter
BKM66_RS00320	COG1132	(ABC) transporter
BKM66_RS00335	COG0789	Transcriptional regulator
BKM66_RS00345	COG2255	four-way junction helicase activity
BKM66_RS00350	COG0546	phosphoglycolate phosphatase activity
BKM66_RS00370	COG0285	dihydrofolate synthase activity
BKM66_RS00385	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BKM66_RS00390	COG0632	four-way junction helicase activity
BKM66_RS00400	COG0519	Catalyzes the synthesis of GMP from XMP
BKM66_RS00415	COG1393	Belongs to the ArsC family
BKM66_RS00420	COG4472	Bacterial protein of unknown function (DUF965)
BKM66_RS00425	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BKM66_RS00430	COG3906	Belongs to the UPF0473 family
BKM66_RS00435	COG0051	transcription antitermination factor activity, RNA binding
BKM66_RS00440	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BKM66_RS00445	COG0088	Forms part of the polypeptide exit tunnel
BKM66_RS00450	COG0089	rRNA binding
BKM66_RS00455	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BKM66_RS00460	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BKM66_RS00465	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BKM66_RS00470	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BKM66_RS00475	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BKM66_RS00480	COG0255	Belongs to the universal ribosomal protein uL29 family
BKM66_RS00485	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BKM66_RS00490	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BKM66_RS00495	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BKM66_RS00500	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BKM66_RS00505	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BKM66_RS00510	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BKM66_RS00515	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BKM66_RS00520	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BKM66_RS00525	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BKM66_RS00530	COG1841	ribosomal large subunit assembly
BKM66_RS00545	COG0563	adenylate kinase activity
BKM66_RS00550	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BKM66_RS00555	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BKM66_RS00560	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BKM66_RS00570	COG0202	RNA polymerase activity
BKM66_RS00690	COG1121	(ABC) transporter
BKM66_RS00700	COG3443	Belongs to the bacterial solute-binding protein 9 family
BKM66_RS00700	COG0803	Belongs to the bacterial solute-binding protein 9 family
BKM66_RS00735	COG0085	RNA polymerase activity
BKM66_RS00740	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BKM66_RS00750	COG1619	proteins homologs of microcin C7 resistance protein MccF
BKM66_RS00755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BKM66_RS00760	COG1459	type II secretion system
BKM66_RS00765	COG4537	Required for transformation and DNA binding
BKM66_RS00795	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BKM66_RS00805	COG0285	dihydrofolate synthase activity
BKM66_RS00810	COG1363	Peptidase, m42
BKM66_RS00820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BKM66_RS00830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BKM66_RS00855	COG0459	protein refolding
BKM66_RS00865	COG0049	tRNA binding
BKM66_RS00870	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BKM66_RS00880	COG0126	phosphoglycerate kinase activity
BKM66_RS00890	COG0789	Transcriptional regulator
BKM66_RS00895	COG0174	glutamine synthetase
BKM66_RS00910	COG1396	sequence-specific DNA binding
BKM66_RS00930	COG1214	PFAM Peptidase M22, glycoprotease
BKM66_RS00940	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BKM66_RS00945	COG2207	Transcriptional regulator
BKM66_RS00955	COG1175	transmembrane transport
BKM66_RS00960	COG0395	ABC-type sugar transport system, permease component
BKM66_RS00980	COG2855	membrane
BKM66_RS00990	COG1131	(ABC) transporter
BKM66_RS00995	COG2081	HI0933 family
BKM66_RS01000	COG2723	6-phospho-beta-galactosidase activity
BKM66_RS01010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BKM66_RS01025	COG3959	Transketolase, thiamine diphosphate binding domain
BKM66_RS01030	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BKM66_RS01035	COG0584	glycerophosphoryl diester phosphodiesterase
BKM66_RS01040	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BKM66_RS01045	COG2222	sugar isomerase
BKM66_RS01070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BKM66_RS01080	COG3942	CHAP domain
BKM66_RS01085	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BKM66_RS01125	COG1882	Formate acetyltransferase
BKM66_RS01140	COG2910	NAD(P)H-binding
BKM66_RS01155	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BKM66_RS01165	COG0681	Belongs to the peptidase S26 family
BKM66_RS01185	COG0366	Alpha amylase catalytic
BKM66_RS01190	COG1263	PTS System
BKM66_RS01190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BKM66_RS01195	COG2188	Transcriptional regulator
BKM66_RS01210	COG1193	negative regulation of DNA recombination
BKM66_RS01220	COG3118	belongs to the thioredoxin family
BKM66_RS01230	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BKM66_RS01230	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BKM66_RS01245	COG1115	amino acid carrier protein
BKM66_RS01265	COG0668	transmembrane transport
BKM66_RS01275	COG3547	Transposase (IS116 IS110 IS902 family)
BKM66_RS01280	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BKM66_RS01290	COG0167	dihydroorotate dehydrogenase activity
BKM66_RS01295	COG2843	Capsule synthesis protein
BKM66_RS01300	COG0561	phosphatase activity
BKM66_RS01315	COG4555	ABC transporter
BKM66_RS01320	COG1309	transcriptional regulator
BKM66_RS01325	COG1511	domain protein
BKM66_RS01325	COG1511	domain protein
BKM66_RS01350	COG1346	cytolysis
BKM66_RS01355	COG2116	formate transmembrane transporter activity
BKM66_RS01360	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BKM66_RS01365	COG0433	COG0433 Predicted ATPase
BKM66_RS01375	COG0494	nUDIX hydrolase
BKM66_RS01380	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BKM66_RS01385	COG1396	sequence-specific DNA binding
BKM66_RS01390	COG0542	response to heat
BKM66_RS01405	COG1349	DNA-binding transcription factor activity
BKM66_RS01415	COG0698	ribose 5-phosphate isomerase
BKM66_RS01420	COG0698	ribose 5-phosphate isomerase
BKM66_RS01425	COG1105	Belongs to the carbohydrate kinase PfkB family
BKM66_RS01430	COG3684	Belongs to the aldolase LacD family
BKM66_RS01435	COG3711	transcriptional antiterminator
BKM66_RS01445	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BKM66_RS01445	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BKM66_RS01470	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BKM66_RS01475	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BKM66_RS01480	COG0124	histidyl-tRNA synthetase
BKM66_RS01485	COG1064	alcohol dehydrogenase
BKM66_RS01490	COG1012	belongs to the aldehyde dehydrogenase family
BKM66_RS01490	COG1454	alcohol dehydrogenase
BKM66_RS01505	COG4988	ABC transporter
BKM66_RS01510	COG1132	(ABC) transporter
BKM66_RS01525	COG1129	ABC transporter
BKM66_RS01530	COG0534	Mate efflux family protein
BKM66_RS01535	COG0515	serine threonine protein kinase
BKM66_RS01540	COG1132	(ABC) transporter
BKM66_RS01550	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BKM66_RS01565	COG1304	FMN binding
BKM66_RS01570	COG3830	Belongs to the UPF0237 family
BKM66_RS01575	COG2848	UPF0210 protein
BKM66_RS01580	COG0588	phosphoglycerate mutase activity
BKM66_RS01595	COG1396	sequence-specific DNA binding
BKM66_RS01620	COG1420	regulation of RNA biosynthetic process
BKM66_RS01625	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BKM66_RS01635	COG0443	Heat shock 70 kDa protein
BKM66_RS01640	COG0484	heat shock protein binding
BKM66_RS01655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BKM66_RS01660	COG0765	amino acid transport
BKM66_RS01665	COG3655	Transcriptional regulator
BKM66_RS01675	COG2217	Heavy metal translocating P-type atpase
BKM66_RS01690	COG0351	phosphomethylpyrimidine kinase
BKM66_RS01700	COG4475	Protein of unknown function (DUF436)
BKM66_RS01705	COG1959	2 iron, 2 sulfur cluster binding
BKM66_RS01710	COG3321	synthase
BKM66_RS01710	COG0604	alcohol dehydrogenase
BKM66_RS01725	COG0544	peptidyl-prolyl cis-trans isomerase activity
BKM66_RS01730	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BKM66_RS01740	COG0251	oxidation-reduction process
BKM66_RS01745	COG0626	cystathionine gamma-synthase activity
BKM66_RS01750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BKM66_RS01755	COG2964	Protein conserved in bacteria
BKM66_RS01780	COG1215	transferase activity, transferring glycosyl groups
BKM66_RS01795	COG3343	RNA polymerase activity
BKM66_RS01800	COG0504	CTP synthase activity
BKM66_RS01810	COG0191	fructose-bisphosphate aldolase activity
BKM66_RS01815	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BKM66_RS01855	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BKM66_RS01860	COG0252	asparaginase activity
BKM66_RS01875	COG0589	response to stress
BKM66_RS01880	COG0436	Aminotransferase
BKM66_RS01885	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BKM66_RS01890	COG1335	isochorismatase
BKM66_RS01895	COG0335	large ribosomal subunit rRNA binding
BKM66_RS01905	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BKM66_RS01910	COG0154	amidase activity
BKM66_RS01915	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BKM66_RS01925	COG1609	Transcriptional regulator
BKM66_RS01930	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BKM66_RS01935	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
BKM66_RS01945	COG3142	Participates in the control of copper homeostasis
BKM66_RS01960	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BKM66_RS01965	COG1534	Rna-binding protein
BKM66_RS01970	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BKM66_RS01975	COG1713	HD superfamily hydrolase involved in NAD metabolism
BKM66_RS01985	COG1335	isochorismatase
BKM66_RS01990	COG0799	negative regulation of ribosome biogenesis
BKM66_RS01995	COG2226	methyltransferase
BKM66_RS02015	COG0789	Transcriptional regulator
BKM66_RS02020	COG2348	transferase activity, transferring amino-acyl groups
BKM66_RS02030	COG0242	peptide deformylase activity
BKM66_RS02045	COG1640	4-alpha-glucanotransferase
BKM66_RS02050	COG0058	SHG alpha-glucan phosphorylase activity
BKM66_RS02080	COG0217	transcriptional regulatory protein
BKM66_RS02090	COG4720	Psort location CytoplasmicMembrane, score
BKM66_RS02100	COG1054	Belongs to the UPF0176 family
BKM66_RS02110	COG1122	ATPase activity
BKM66_RS02125	COG0357	Ribosomal RNA small subunit methyltransferase G
BKM66_RS02130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BKM66_RS02135	COG3331	DNA recombination
BKM66_RS02140	COG4474	Belongs to the UPF0398 family
BKM66_RS02145	COG3599	regulation of cell shape
BKM66_RS02155	COG0116	Belongs to the methyltransferase superfamily
BKM66_RS02165	COG1854	S-ribosylhomocysteine lyase activity
BKM66_RS02170	COG1418	mRNA catabolic process
BKM66_RS02180	COG1758	RNA polymerase activity
BKM66_RS02185	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BKM66_RS02190	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BKM66_RS02195	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BKM66_RS02195	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BKM66_RS02200	COG0631	protein serine/threonine phosphatase activity
BKM66_RS02205	COG0515	serine threonine protein kinase
BKM66_RS02205	COG2815	serine threonine protein kinase
BKM66_RS02230	COG1098	S1 RNA binding domain
BKM66_RS02240	COG1739	Uncharacterized protein family UPF0029
BKM66_RS02245	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BKM66_RS02340	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BKM66_RS02350	COG3557	Belongs to the UPF0374 family
BKM66_RS02360	COG2188	Transcriptional regulator
BKM66_RS02365	COG2188	Transcriptional regulator
BKM66_RS02375	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BKM66_RS02385	COG3716	PTS system mannose fructose sorbose family IID component
BKM66_RS02400	COG2017	converts alpha-aldose to the beta-anomer
BKM66_RS02415	COG0346	lactoylglutathione lyase activity
BKM66_RS02440	COG0270	DNA (cytosine-5-)-methyltransferase activity
BKM66_RS02465	COG1217	gtp-binding protein TYPA
BKM66_RS02480	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BKM66_RS02500	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BKM66_RS02505	COG1799	cell septum assembly
BKM66_RS02520	COG3599	regulation of cell shape
BKM66_RS02540	COG0494	nUDIX hydrolase
BKM66_RS02540	COG0406	alpha-ribazole phosphatase activity
BKM66_RS02545	COG0542	response to heat
BKM66_RS02550	COG4703	Protein of unknown function (DUF1797)
BKM66_RS02555	COG0765	amino acid transport
BKM66_RS02565	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BKM66_RS02595	COG3590	peptidase
BKM66_RS02610	COG0745	RESPONSE REGULATOR receiver
BKM66_RS02615	COG5002	protein histidine kinase activity
BKM66_RS02615	COG3850	Histidine kinase
BKM66_RS02620	COG1755	Isoprenylcysteine carboxyl methyltransferase
BKM66_RS02635	COG1755	Isoprenylcysteine carboxyl methyltransferase
BKM66_RS02645	COG2321	neutral zinc metallopeptidase
BKM66_RS02650	COG1570	exodeoxyribonuclease VII activity
BKM66_RS02655	COG1722	exodeoxyribonuclease VII activity
BKM66_RS02665	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BKM66_RS02670	COG1438	arginine binding
BKM66_RS02675	COG0497	DNA recombination
BKM66_RS02695	COG0776	regulation of translation
BKM66_RS02710	COG3425	synthase
BKM66_RS02715	COG0183	Belongs to the thiolase family
BKM66_RS02730	COG0726	polysaccharide deacetylase
BKM66_RS02735	COG0513	Belongs to the DEAD box helicase family
BKM66_RS02740	COG0673	inositol 2-dehydrogenase activity
BKM66_RS02750	COG1695	Transcriptional regulator
BKM66_RS02760	COG1956	GAF domain-containing protein
BKM66_RS02780	COG1363	Peptidase, m42
BKM66_RS02790	COG2131	deaminase
BKM66_RS02795	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BKM66_RS02800	COG2249	NAD(P)H dehydrogenase (quinone) activity
BKM66_RS02805	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BKM66_RS02815	COG0024	Methionine aminopeptidase
BKM66_RS02825	COG2246	polysaccharide biosynthetic process
BKM66_RS02835	COG0656	L-ascorbic acid biosynthetic process
BKM66_RS02840	COG2183	response to ionizing radiation
BKM66_RS02845	COG3091	SprT-like family
BKM66_RS02860	COG1482	cell wall glycoprotein biosynthetic process
BKM66_RS02865	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BKM66_RS02870	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BKM66_RS02885	COG1733	regulation of RNA biosynthetic process
BKM66_RS02910	COG1125	glycine betaine transport
BKM66_RS02910	COG0517	IMP dehydrogenase activity
BKM66_RS02915	COG1174	glycine betaine transport
BKM66_RS02925	COG0436	Aminotransferase
BKM66_RS02945	COG2205	protein histidine kinase activity
BKM66_RS02950	COG1136	(ABC) transporter
BKM66_RS02955	COG0577	efflux transmembrane transporter activity
BKM66_RS02975	COG2264	protein methyltransferase activity
BKM66_RS02995	COG0732	type I restriction modification DNA specificity domain
BKM66_RS03020	COG1028	Short-chain dehydrogenase reductase Sdr
BKM66_RS03025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BKM66_RS03035	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BKM66_RS03040	COG0494	nUDIX hydrolase
BKM66_RS03050	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BKM66_RS03080	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BKM66_RS03100	COG1609	Transcriptional regulator
BKM66_RS03105	COG1653	transport
BKM66_RS03110	COG1175	transmembrane transport
BKM66_RS03115	COG0395	ABC-type sugar transport system, permease component
BKM66_RS03125	COG1674	ftsk spoiiie
BKM66_RS03125	COG0697	spore germination
BKM66_RS03130	COG0346	lactoylglutathione lyase activity
BKM66_RS03155	COG0625	glutathione transferase activity
BKM66_RS03165	COG2244	polysaccharide biosynthetic process
BKM66_RS03170	COG0528	UMP kinase activity
BKM66_RS03175	COG0233	cytoplasmic translational termination
BKM66_RS03180	COG2996	Protein conserved in bacteria
BKM66_RS03195	COG4479	Belongs to the UPF0346 family
BKM66_RS03200	COG1702	phosphate starvation-inducible protein PhoH
BKM66_RS03220	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BKM66_RS03225	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BKM66_RS03230	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BKM66_RS03245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BKM66_RS03250	COG3022	response to hydroperoxide
BKM66_RS03255	COG1316	TRANSCRIPTIONal
BKM66_RS03260	COG3944	biosynthesis protein
BKM66_RS03270	COG4464	protein tyrosine phosphatase activity
BKM66_RS03285	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BKM66_RS03290	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BKM66_RS03295	COG3475	LICD family
BKM66_RS03300	COG0110	maltose O-acetyltransferase activity
BKM66_RS03305	COG0438	transferase activity, transferring glycosyl groups
BKM66_RS03330	COG0562	UDP-galactopyranose mutase
BKM66_RS03335	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BKM66_RS03350	COG0436	Aminotransferase
BKM66_RS03360	COG0017	Asparaginyl-tRNA synthetase
BKM66_RS03375	COG0534	Mate efflux family protein
BKM66_RS03380	COG0251	oxidation-reduction process
BKM66_RS03385	COG1660	Displays ATPase and GTPase activities
BKM66_RS03390	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BKM66_RS03395	COG1481	regulation of sporulation
BKM66_RS03410	COG0454	-acetyltransferase
BKM66_RS03415	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BKM66_RS03420	COG0549	Belongs to the carbamate kinase family
BKM66_RS03425	COG1288	antiporter activity
BKM66_RS03430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BKM66_RS03435	COG3064	Membrane
BKM66_RS03435	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BKM66_RS03435	COG3583	domain protein
BKM66_RS03445	COG0443	Heat shock 70 kDa protein
BKM66_RS03455	COG1438	arginine binding
BKM66_RS03465	COG0363	glucosamine-6-phosphate deaminase activity
BKM66_RS03475	COG0435	Glutathione S-transferase
BKM66_RS03480	COG1187	pseudouridine synthase activity
BKM66_RS03485	COG0386	Belongs to the glutathione peroxidase family
BKM66_RS03490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BKM66_RS03495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BKM66_RS03500	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BKM66_RS03505	COG1120	ATPase activity
BKM66_RS03510	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BKM66_RS03515	COG0204	Acyl-transferase
BKM66_RS03520	COG1555	photosystem II stabilization
BKM66_RS03520	COG1596	polysaccharide export
BKM66_RS03525	COG2333	competence protein COMEC
BKM66_RS03525	COG0658	competence protein
BKM66_RS03535	COG3547	Transposase (IS116 IS110 IS902 family)
BKM66_RS03540	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
BKM66_RS03540	COG3583	domain protein
BKM66_RS03545	COG1466	dna polymerase III delta subunit
BKM66_RS03550	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BKM66_RS03555	COG0737	Belongs to the 5'-nucleotidase family
BKM66_RS03570	COG0038	chloride channel
BKM66_RS03575	COG0287	Prephenate dehydrogenase
BKM66_RS03575	COG1605	Chorismate mutase
BKM66_RS03585	COG0716	FMN binding
BKM66_RS03590	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BKM66_RS03610	COG0772	Belongs to the SEDS family
BKM66_RS03615	COG0693	protein deglycase activity
BKM66_RS03620	COG0187	DNA topoisomerase II activity
BKM66_RS03625	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BKM66_RS03630	COG0560	Phosphoserine phosphatase
BKM66_RS03665	COG1011	Hydrolase
BKM66_RS03675	COG2706	6-phosphogluconolactonase activity
BKM66_RS03680	COG0628	permease
BKM66_RS03690	COG3527	Alpha-acetolactate decarboxylase
BKM66_RS03695	COG1293	RNA-binding protein homologous to eukaryotic snRNP
BKM66_RS03710	COG3842	ATPase activity
BKM66_RS03745	COG0488	(ABC) transporter
BKM66_RS03760	COG2226	methyltransferase
BKM66_RS03785	COG3442	glutamine amidotransferase
BKM66_RS03790	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BKM66_RS03805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BKM66_RS03810	COG0488	(ABC) transporter
BKM66_RS03815	COG2226	methyltransferase
BKM66_RS03840	COG1573	uracil-dna glycosylase
BKM66_RS03850	COG1704	LemA family
BKM66_RS03855	COG2268	Band 7 protein
BKM66_RS03870	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BKM66_RS03890	COG1674	ftsk spoiiie
BKM66_RS03900	COG2946	Replication initiation factor
BKM66_RS03930	COG0741	lytic transglycosylase activity
BKM66_RS03930	COG0791	NLP P60 protein
BKM66_RS03995	COG1518	maintenance of DNA repeat elements
BKM66_RS04000	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BKM66_RS04010	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BKM66_RS04015	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BKM66_RS04020	COG1393	Belongs to the ArsC family
BKM66_RS04025	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BKM66_RS04030	COG0813	purine-nucleoside phosphorylase activity
BKM66_RS04040	COG0058	SHG alpha-glucan phosphorylase activity
BKM66_RS04050	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BKM66_RS04060	COG1051	belongs to the nudix hydrolase family
BKM66_RS04065	COG0647	UMP catabolic process
BKM66_RS04075	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BKM66_RS04080	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BKM66_RS04085	COG1970	mechanosensitive ion channel activity
BKM66_RS04090	COG0358	DNA primase activity
BKM66_RS04095	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BKM66_RS04100	COG2151	metal-sulfur cluster biosynthetic enzyme
BKM66_RS04105	COG1982	Orn Lys Arg decarboxylase major
BKM66_RS04110	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BKM66_RS04150	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BKM66_RS04160	COG1131	(ABC) transporter
BKM66_RS04165	COG2188	Transcriptional regulator
BKM66_RS04175	COG0205	6-phosphofructokinase activity
BKM66_RS04180	COG0469	pyruvate kinase activity
BKM66_RS04210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BKM66_RS04215	COG2755	lipolytic protein G-D-S-L family
BKM66_RS04215	COG0657	acetylesterase activity
BKM66_RS04225	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BKM66_RS04230	COG0765	amino acid transport
BKM66_RS04235	COG1126	abc transporter atp-binding protein
BKM66_RS04240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BKM66_RS04245	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BKM66_RS04260	COG1846	Transcriptional regulator
BKM66_RS04265	COG3759	membrane
BKM66_RS04300	COG2195	Cleaves the N-terminal amino acid of tripeptides
BKM66_RS04305	COG0561	phosphatase activity
BKM66_RS04340	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BKM66_RS04345	COG0196	riboflavin kinase activity
BKM66_RS04350	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BKM66_RS04355	COG1393	Belongs to the ArsC family
BKM66_RS04360	COG4476	Belongs to the UPF0223 family
BKM66_RS04365	COG0483	inositol monophosphate 1-phosphatase activity
BKM66_RS04370	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BKM66_RS04370	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
BKM66_RS04380	COG0573	inorganic phosphate transmembrane transporter activity
BKM66_RS04385	COG0581	inorganic phosphate transmembrane transporter activity
BKM66_RS04390	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BKM66_RS04395	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BKM66_RS04410	COG0745	RESPONSE REGULATOR receiver
BKM66_RS04415	COG5002	protein histidine kinase activity
BKM66_RS04430	COG1072	(Pantothenic acid kinase))
BKM66_RS04435	COG2813	Specifically methylates the guanine in position
BKM66_RS04440	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
BKM66_RS04450	COG0295	cytidine deaminase activity
BKM66_RS04455	COG1744	ABC transporter substrate-binding protein PnrA-like
BKM66_RS04460	COG3845	ABC transporter
BKM66_RS04465	COG4603	Belongs to the binding-protein-dependent transport system permease family
BKM66_RS04470	COG1079	Belongs to the binding-protein-dependent transport system permease family
BKM66_RS04480	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BKM66_RS04485	COG0039	L-malate dehydrogenase activity
BKM66_RS04490	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BKM66_RS04495	COG3764	Sortase (surface protein transpeptidase)
BKM66_RS04510	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BKM66_RS04525	COG1104	cysteine desulfurase activity
BKM66_RS04535	COG4116	CYTH
BKM66_RS04540	COG2357	RelA SpoT domain protein
BKM66_RS04545	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BKM66_RS04550	COG0564	pseudouridine synthase activity
BKM66_RS04555	COG0280	phosphate acetyltransferase
BKM66_RS04565	COG1132	(ABC) transporter
BKM66_RS04575	COG1194	a g-specific adenine glycosylase
BKM66_RS04580	COG1396	sequence-specific DNA binding
BKM66_RS04600	COG2873	o-acetylhomoserine
BKM66_RS04605	COG0488	(ABC) transporter
BKM66_RS04630	COG1126	abc transporter atp-binding protein
BKM66_RS04645	COG3583	domain protein
BKM66_RS04660	COG0789	Transcriptional regulator
BKM66_RS04660	COG4978	Transcriptional regulator
BKM66_RS04680	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
BKM66_RS04685	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
BKM66_RS04690	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BKM66_RS04695	COG1882	Formate acetyltransferase
BKM66_RS04700	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BKM66_RS04730	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
BKM66_RS04735	COG4766	ethanolamine catabolic process
BKM66_RS04745	COG1454	alcohol dehydrogenase
BKM66_RS04745	COG1012	belongs to the aldehyde dehydrogenase family
BKM66_RS04750	COG4869	propanediol catabolic process
BKM66_RS04775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BKM66_RS04780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BKM66_RS04790	COG0297	glycogen (starch) synthase activity
BKM66_RS04800	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BKM66_RS04810	COG0543	2 iron, 2 sulfur cluster binding
BKM66_RS04815	COG0167	dihydroorotate dehydrogenase activity
BKM66_RS04820	COG0284	orotidine-5'-phosphate decarboxylase activity
BKM66_RS04825	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BKM66_RS04835	COG0463	Glycosyl transferase, family 2
BKM66_RS04840	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BKM66_RS04850	COG0737	Belongs to the 5'-nucleotidase family
BKM66_RS04865	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BKM66_RS04870	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BKM66_RS04880	COG1272	protein, Hemolysin III
BKM66_RS04890	COG0446	pyridine nucleotide-disulphide oxidoreductase
BKM66_RS04895	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BKM66_RS04900	COG1937	Protein conserved in bacteria
BKM66_RS04905	COG0110	maltose O-acetyltransferase activity
BKM66_RS04910	COG0758	DNA mediated transformation
BKM66_RS04915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BKM66_RS04920	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BKM66_RS04925	COG0222	ribosome binding
BKM66_RS04930	COG0647	UMP catabolic process
BKM66_RS04935	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BKM66_RS04945	COG2382	esterase
BKM66_RS04970	COG1136	(ABC) transporter
BKM66_RS04975	COG0577	efflux transmembrane transporter activity
BKM66_RS04990	COG0745	RESPONSE REGULATOR receiver
BKM66_RS05010	COG4974	Belongs to the 'phage' integrase family
BKM66_RS05015	COG1660	Displays ATPase and GTPase activities
BKM66_RS05030	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BKM66_RS05035	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BKM66_RS05040	COG2188	Transcriptional regulator
BKM66_RS05110	COG4268	DNA restriction-modification system
BKM66_RS05115	COG1401	restriction endodeoxyribonuclease activity
BKM66_RS05140	COG4221	oxidoreductase activity
BKM66_RS05170	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BKM66_RS05180	COG0009	L-threonylcarbamoyladenylate synthase
BKM66_RS05185	COG2890	protein-(glutamine-N5) methyltransferase activity
BKM66_RS05190	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BKM66_RS05215	COG0481	GTPase activity
BKM66_RS05235	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BKM66_RS05245	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BKM66_RS05250	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BKM66_RS05265	COG1940	carbohydrate kinase activity
BKM66_RS05275	COG0488	(ABC) transporter
BKM66_RS05280	COG0617	tRNA 3'-terminal CCA addition
BKM66_RS05285	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BKM66_RS05290	COG1307	EDD domain protein, DegV family
BKM66_RS05300	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BKM66_RS05300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BKM66_RS05300	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BKM66_RS05305	COG1105	Belongs to the carbohydrate kinase PfkB family
BKM66_RS05310	COG1349	DNA-binding transcription factor activity
BKM66_RS05315	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BKM66_RS05320	COG0336	Belongs to the RNA methyltransferase TrmD family
BKM66_RS05325	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BKM66_RS05330	COG0534	Mate efflux family protein
BKM66_RS05340	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BKM66_RS05345	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BKM66_RS05360	COG1177	transmembrane transport
BKM66_RS05365	COG1176	ABC-type spermidine putrescine transport system, permease component I
BKM66_RS05370	COG3842	ATPase activity
BKM66_RS05375	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BKM66_RS05380	COG0083	homoserine kinase activity
BKM66_RS05385	COG0460	homoserine dehydrogenase
BKM66_RS05390	COG0726	polysaccharide deacetylase
BKM66_RS05395	COG1132	(ABC) transporter
BKM66_RS05410	COG0228	four-way junction DNA binding
BKM66_RS05420	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BKM66_RS05425	COG2136	Putative SAM-dependent methyltransferase
BKM66_RS05425	COG2521	methyltransferase
BKM66_RS05440	COG0505	Belongs to the CarA family
BKM66_RS05445	COG0540	Belongs to the ATCase OTCase family
BKM66_RS05450	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BKM66_RS05460	COG2824	Alkylphosphonate utilization operon protein PhnA
BKM66_RS05465	COG0564	pseudouridine synthase activity
BKM66_RS05485	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BKM66_RS05490	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BKM66_RS05500	COG1114	Component of the transport system for branched-chain amino acids
BKM66_RS05505	COG0301	tRNA thio-modification
BKM66_RS05510	COG1104	cysteine desulfurase activity
BKM66_RS05535	COG0539	negative regulation of cytoplasmic translation
BKM66_RS05555	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BKM66_RS05565	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BKM66_RS05580	COG0187	DNA topoisomerase II activity
BKM66_RS05590	COG1074	ATP-dependent DNA helicase activity
BKM66_RS05595	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BKM66_RS05640	COG1131	(ABC) transporter
BKM66_RS05670	COG1011	Hydrolase
BKM66_RS05680	COG0210	DNA helicase
BKM66_RS05695	COG1164	Oligoendopeptidase f
BKM66_RS05705	COG0346	lactoylglutathione lyase activity
BKM66_RS05710	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BKM66_RS05715	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BKM66_RS05720	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BKM66_RS05730	COG0446	pyridine nucleotide-disulphide oxidoreductase
BKM66_RS05735	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BKM66_RS05740	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BKM66_RS05760	COG1882	Formate acetyltransferase
BKM66_RS05765	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BKM66_RS05770	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BKM66_RS05775	COG1447	Phosphotransferase system cellobiose-specific component IIA
BKM66_RS05785	COG1349	DNA-binding transcription factor activity
BKM66_RS05790	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BKM66_RS05820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BKM66_RS05830	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BKM66_RS05840	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BKM66_RS05845	COG4684	Psort location CytoplasmicMembrane, score
BKM66_RS05850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BKM66_RS05860	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BKM66_RS05870	COG0500	methyltransferase
BKM66_RS05880	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BKM66_RS05890	COG0077	Prephenate dehydratase
BKM66_RS05895	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BKM66_RS05905	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BKM66_RS05910	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BKM66_RS05915	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BKM66_RS05920	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BKM66_RS05925	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BKM66_RS05925	COG1116	anion transmembrane transporter activity
BKM66_RS05930	COG4120	Belongs to the binding-protein-dependent transport system permease family
BKM66_RS05950	COG3684	Belongs to the aldolase LacD family
BKM66_RS05960	COG3679	Belongs to the UPF0342 family
BKM66_RS05965	COG0287	Prephenate dehydrogenase
BKM66_RS05970	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BKM66_RS05975	COG0710	3-dehydroquinate dehydratase activity
BKM66_RS05980	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BKM66_RS05985	COG1368	sulfuric ester hydrolase activity
BKM66_RS06000	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BKM66_RS06010	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BKM66_RS06045	COG1216	Glycosyl transferase, family 2
BKM66_RS06050	COG1442	glycosyl transferase family 8
BKM66_RS06070	COG1368	sulfuric ester hydrolase activity
BKM66_RS06095	COG1216	Glycosyl transferase, family 2
BKM66_RS06095	COG1442	glycosyl transferase family 8
BKM66_RS06125	COG1091	dTDP-4-dehydrorhamnose reductase activity
BKM66_RS06130	COG1088	dTDP-glucose 4,6-dehydratase activity
BKM66_RS06145	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BKM66_RS06155	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BKM66_RS06175	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BKM66_RS06185	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BKM66_RS06185	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BKM66_RS06190	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BKM66_RS06195	COG2217	Heavy metal translocating P-type atpase
BKM66_RS06200	COG0300	oxidoreductase activity
BKM66_RS06205	COG1234	tRNA 3'-trailer cleavage
BKM66_RS06215	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BKM66_RS06220	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BKM66_RS06230	COG2807	transmembrane transport
BKM66_RS06235	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BKM66_RS06240	COG2610	gluconate transmembrane transporter activity
BKM66_RS06260	COG0302	gtp cyclohydrolase
BKM66_RS06265	COG1051	belongs to the nudix hydrolase family
BKM66_RS06290	COG0072	phenylalanine-tRNA ligase activity
BKM66_RS06290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BKM66_RS06320	COG1028	Short-chain dehydrogenase reductase Sdr
BKM66_RS06325	COG1312	Catalyzes the dehydration of D-mannonate
BKM66_RS06335	COG0800	Aldolase
BKM66_RS06345	COG3250	beta-galactosidase activity
BKM66_RS06355	COG2211	Major facilitator Superfamily
BKM66_RS06370	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BKM66_RS06380	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BKM66_RS06385	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BKM66_RS06390	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BKM66_RS06395	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BKM66_RS06400	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BKM66_RS06405	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BKM66_RS06410	COG0356	it plays a direct role in the translocation of protons across the membrane
BKM66_RS06420	COG1597	lipid kinase activity
BKM66_RS06430	COG0701	Predicted permease
BKM66_RS06435	COG3689	TIGRFAM TIGR03943 family protein
BKM66_RS06440	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BKM66_RS06460	COG0552	protein localization to endoplasmic reticulum
BKM66_RS06465	COG0561	phosphatase activity
BKM66_RS06470	COG0561	phosphatase activity
BKM66_RS06475	COG1196	nuclear chromosome segregation
BKM66_RS06510	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BKM66_RS06515	COG0538	isocitrate dehydrogenase activity
BKM66_RS06520	COG0372	Belongs to the citrate synthase family
BKM66_RS06525	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BKM66_RS06530	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BKM66_RS06535	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BKM66_RS06540	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BKM66_RS06575	COG1476	TRANSCRIPTIONal
BKM66_RS06595	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BKM66_RS06605	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BKM66_RS06610	COG4122	O-methyltransferase activity
BKM66_RS06650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BKM66_RS06650	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BKM66_RS06690	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BKM66_RS06715	COG0531	amino acid
BKM66_RS06725	COG0708	Exodeoxyribonuclease III
BKM66_RS06740	COG1393	Belongs to the ArsC family
BKM66_RS06745	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BKM66_RS06750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BKM66_RS06760	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BKM66_RS06770	COG4467	Involved in initiation control of chromosome replication
BKM66_RS06775	COG0470	DNA polymerase III
BKM66_RS06780	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BKM66_RS06785	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BKM66_RS06800	COG0517	IMP dehydrogenase activity
BKM66_RS06830	COG0559	Belongs to the binding-protein-dependent transport system permease family
BKM66_RS06835	COG0683	leucine binding
BKM66_RS06850	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BKM66_RS06855	COG0366	Alpha amylase catalytic
BKM66_RS06865	COG0395	ABC-type sugar transport system, permease component
BKM66_RS06870	COG1175	transmembrane transport
BKM66_RS06875	COG1653	transport
BKM66_RS06885	COG2207	Transcriptional regulator
BKM66_RS06890	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BKM66_RS06895	COG0626	cystathionine gamma-synthase activity
BKM66_RS06915	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BKM66_RS06920	COG2827	Endonuclease containing a URI domain
BKM66_RS06940	COG0640	Transcriptional regulator
BKM66_RS06945	COG0513	Belongs to the DEAD box helicase family
BKM66_RS06955	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BKM66_RS06985	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BKM66_RS06995	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BKM66_RS07020	COG1181	Belongs to the D-alanine--D-alanine ligase family
BKM66_RS07025	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BKM66_RS07030	COG0768	penicillin binding
BKM66_RS07035	COG0488	(ABC) transporter
BKM66_RS07040	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BKM66_RS07050	COG0745	RESPONSE REGULATOR receiver
BKM66_RS07060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BKM66_RS07065	COG0765	amino acid transport
BKM66_RS07070	COG0765	amino acid transport
BKM66_RS07075	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BKM66_RS07090	COG0438	transferase activity, transferring glycosyl groups
BKM66_RS07105	COG5002	protein histidine kinase activity
BKM66_RS07115	COG1609	Transcriptional regulator
BKM66_RS07135	COG0343	queuine tRNA-ribosyltransferase activity
BKM66_RS07145	COG1832	CoA-binding protein
BKM66_RS07170	COG1136	(ABC) transporter
BKM66_RS07185	COG1131	(ABC) transporter
BKM66_RS07195	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BKM66_RS07200	COG0583	DNA-binding transcription factor activity
BKM66_RS07210	COG0110	maltose O-acetyltransferase activity
BKM66_RS07215	COG2217	Heavy metal translocating P-type atpase
BKM66_RS07245	COG1063	alcohol dehydrogenase
BKM66_RS07255	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BKM66_RS07260	COG0557	exoribonuclease II activity
BKM66_RS07270	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BKM66_RS07275	COG2814	Major facilitator Superfamily
BKM66_RS07285	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BKM66_RS07295	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BKM66_RS07300	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BKM66_RS07310	COG1737	Transcriptional regulator
BKM66_RS07330	COG1011	Hydrolase
BKM66_RS07335	COG1132	(ABC) transporter
BKM66_RS07340	COG1132	(ABC) transporter
BKM66_RS07370	COG2177	Part of the ABC transporter FtsEX involved in
BKM66_RS07375	COG2884	Cell division ATP-binding protein ftsE
BKM66_RS07385	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BKM66_RS07425	COG1078	dGTPase activity
BKM66_RS07435	COG0149	triose-phosphate isomerase activity
BKM66_RS07440	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BKM66_RS07455	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BKM66_RS07460	COG0772	Belongs to the SEDS family
BKM66_RS07490	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BKM66_RS07500	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BKM66_RS07510	COG0577	efflux transmembrane transporter activity
BKM66_RS07515	COG1136	(ABC) transporter
BKM66_RS07520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BKM66_RS07525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BKM66_RS07530	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BKM66_RS07535	COG1268	BioY protein
BKM66_RS07540	COG4443	Transcriptional Coactivator p15 (PC4)
BKM66_RS07550	COG0826	peptidase U32
BKM66_RS07565	COG0789	Transcriptional regulator
BKM66_RS07575	COG1227	inorganic diphosphatase activity
BKM66_RS07585	COG1733	regulation of RNA biosynthetic process
BKM66_RS07590	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BKM66_RS07595	COG2514	catechol 2,3-dioxygenase activity
BKM66_RS07600	COG1472	Belongs to the glycosyl hydrolase 3 family
BKM66_RS07605	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BKM66_RS07610	COG1253	flavin adenine dinucleotide binding
BKM66_RS07615	COG1119	ATPase activity
BKM66_RS07620	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BKM66_RS07640	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BKM66_RS07645	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BKM66_RS07650	COG0133	tryptophan synthase activity
BKM66_RS07665	COG4470	Protein conserved in bacteria
BKM66_RS07670	COG3480	Lon protease (S16) C-terminal proteolytic domain
BKM66_RS07675	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BKM66_RS07680	COG0742	ribosomal rna small subunit methyltransferase
BKM66_RS07690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BKM66_RS07695	COG4483	Protein conserved in bacteria
BKM66_RS07700	COG2197	response regulator
BKM66_RS07705	COG4585	Histidine kinase
BKM66_RS07710	COG0842	Transport permease protein
BKM66_RS07715	COG1131	(ABC) transporter
BKM66_RS07730	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BKM66_RS07745	COG0671	phosphoesterase, PA-phosphatase related
BKM66_RS07750	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BKM66_RS07765	COG0747	negative chemotaxis
BKM66_RS07770	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BKM66_RS07775	COG1187	pseudouridine synthase activity
BKM66_RS07780	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BKM66_RS07785	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BKM66_RS07790	COG0582	viral genome integration into host DNA
BKM66_RS07810	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BKM66_RS07815	COG3763	UPF0154 protein
BKM66_RS07825	COG3579	cysteine-type endopeptidase activity
BKM66_RS07840	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BKM66_RS07845	COG1254	Belongs to the acylphosphatase family
BKM66_RS07855	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BKM66_RS07860	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BKM66_RS07870	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BKM66_RS07880	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BKM66_RS07895	COG1160	GTP binding
BKM66_RS07905	COG1484	DNA-dependent DNA replication
BKM66_RS07915	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BKM66_RS07920	COG0628	permease
BKM66_RS07925	COG0745	RESPONSE REGULATOR receiver
BKM66_RS07930	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BKM66_RS07940	COG0492	ferredoxin-NADP+ reductase activity
BKM66_RS07950	COG0513	Belongs to the DEAD box helicase family
BKM66_RS07955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BKM66_RS07960	COG0768	penicillin binding
BKM66_RS07970	COG0275	rRNA processing
BKM66_RS08015	COG4939	FMN-binding domain protein
BKM66_RS08020	COG0142	geranyltranstransferase activity
BKM66_RS08025	COG1252	NADH dehydrogenase
BKM66_RS08040	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BKM66_RS08045	COG0569	domain protein
BKM66_RS08050	COG0534	Mate efflux family protein
BKM66_RS08065	COG0751	glycine-tRNA ligase activity
BKM66_RS08090	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BKM66_RS08095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BKM66_RS08100	COG1464	Belongs to the NlpA lipoprotein family
BKM66_RS08105	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BKM66_RS08110	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BKM66_RS08115	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BKM66_RS08120	COG2252	PERMEase
BKM66_RS08125	COG0561	phosphatase activity
BKM66_RS08135	COG3715	PTS system
BKM66_RS08140	COG3716	PTS system mannose fructose sorbose family IID component
BKM66_RS08155	COG1983	PspC domain protein
BKM66_RS08160	COG1266	CAAX protease self-immunity
BKM66_RS08180	COG0439	Biotin carboxylase
BKM66_RS08200	COG1028	Short-chain dehydrogenase reductase Sdr
BKM66_RS08205	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BKM66_RS08210	COG2070	2-Nitropropane dioxygenase
BKM66_RS08220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BKM66_RS08230	COG1024	Enoyl-CoA hydratase
BKM66_RS08235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BKM66_RS08240	COG0527	aspartate kinase activity
BKM66_RS08245	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BKM66_RS08250	COG0736	holo-[acyl-carrier-protein] synthase activity
BKM66_RS08255	COG0653	protein targeting
BKM66_RS08260	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
BKM66_RS08260	COG3583	domain protein
BKM66_RS08265	COG1940	carbohydrate kinase activity
BKM66_RS08270	COG2190	(PTS) system
BKM66_RS08270	COG1263	PTS System
BKM66_RS08270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BKM66_RS08275	COG1621	beta-fructofuranosidase activity
BKM66_RS08280	COG1609	Transcriptional regulator
BKM66_RS08285	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BKM66_RS08300	COG0006	proline dipeptidase activity
BKM66_RS08305	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BKM66_RS08320	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BKM66_RS08325	COG0629	single-stranded DNA binding
BKM66_RS08335	COG0095	Lipoate-protein ligase
BKM66_RS08340	COG2723	6-phospho-beta-galactosidase activity
BKM66_RS08355	COG2723	6-phospho-beta-galactosidase activity
BKM66_RS08360	COG0346	lactoylglutathione lyase activity
BKM66_RS08365	COG2723	6-phospho-beta-galactosidase activity
BKM66_RS08370	COG2207	Transcriptional regulator
BKM66_RS08380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BKM66_RS08380	COG2190	(PTS) system
BKM66_RS08380	COG1263	PTS System
BKM66_RS08400	COG4095	Psort location CytoplasmicMembrane, score
BKM66_RS08415	COG0508	dehydrogenase complex catalyzes the overall conversion of
BKM66_RS08420	COG0022	dehydrogenase e1 component
BKM66_RS08420	COG0508	dehydrogenase complex catalyzes the overall conversion of
BKM66_RS08425	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BKM66_RS08430	COG2860	membrane
BKM66_RS08445	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BKM66_RS08450	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BKM66_RS08460	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BKM66_RS08465	COG0195	Participates in both transcription termination and antitermination
BKM66_RS08475	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BKM66_RS08485	COG4473	ABC transporter
BKM66_RS08490	COG1131	(ABC) transporter
BKM66_RS08495	COG0537	adenosine 5'-monophosphoramidase activity
BKM66_RS08505	COG1316	TRANSCRIPTIONal
BKM66_RS08515	COG0802	atpase or kinase
BKM66_RS08520	COG1461	Dihydroxyacetone kinase
BKM66_RS08530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BKM66_RS08535	COG0601	transmembrane transport
BKM66_RS08540	COG4608	Belongs to the ABC transporter superfamily
BKM66_RS08555	COG1686	Belongs to the peptidase S11 family
BKM66_RS08575	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BKM66_RS08580	COG0719	Fe-S assembly protein
BKM66_RS08590	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BKM66_RS08595	COG4862	establishment of competence for transformation
BKM66_RS08600	COG1968	undecaprenyl-diphosphatase activity
BKM66_RS08605	COG0765	amino acid transport
BKM66_RS08625	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BKM66_RS08630	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BKM66_RS08635	COG0440	acetolactate synthase activity
BKM66_RS08645	COG0463	Glycosyl transferase, family 2
BKM66_RS08675	COG2151	metal-sulfur cluster biosynthetic enzyme
BKM66_RS08730	COG1216	Glycosyl transferase, family 2
BKM66_RS08730	COG1442	glycosyl transferase family 8
BKM66_RS08745	COG1216	Glycosyl transferase, family 2
BKM66_RS08745	COG1442	glycosyl transferase family 8
BKM66_RS08755	COG1442	glycosyl transferase family 8
BKM66_RS08805	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BKM66_RS08830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BKM66_RS08855	COG3842	ATPase activity
BKM66_RS08865	COG4753	response regulator
BKM66_RS08865	COG2207	Transcriptional regulator
BKM66_RS08870	COG2972	Histidine kinase
BKM66_RS08885	COG3547	Transposase (IS116 IS110 IS902 family)
BKM66_RS08890	COG1653	transport
BKM66_RS08895	COG0395	ABC-type sugar transport system, permease component
BKM66_RS08900	COG1175	transmembrane transport
BKM66_RS08945	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BKM66_RS08960	COG1045	serine acetyltransferase
BKM66_RS08965	COG1185	polyribonucleotide nucleotidyltransferase activity
BKM66_RS08985	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BKM66_RS09015	COG0464	growth
BKM66_RS09030	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BKM66_RS09035	COG1187	pseudouridine synthase activity
BKM66_RS09055	COG0242	peptide deformylase activity
BKM66_RS09085	COG0066	3-isopropylmalate dehydratase activity
BKM66_RS09115	COG2309	aminopeptidase activity
BKM66_RS09135	COG2176	DNA-directed DNA polymerase activity
BKM66_RS09155	COG2376	Dihydroxyacetone kinase
BKM66_RS09165	COG2376	Dihydroxyacetone kinase
BKM66_RS09170	COG1461	Dihydroxyacetone kinase
BKM66_RS09175	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
BKM66_RS09180	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BKM66_RS09185	COG0442	prolyl-tRNA aminoacylation
BKM66_RS09195	COG4589	Belongs to the CDS family
BKM66_RS09200	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BKM66_RS09205	COG1862	Preprotein translocase
BKM66_RS09215	COG2918	glutathione biosynthetic process
BKM66_RS09215	COG1181	Belongs to the D-alanine--D-alanine ligase family
BKM66_RS09225	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BKM66_RS09230	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BKM66_RS09235	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BKM66_RS09240	COG0454	-acetyltransferase
BKM66_RS09250	COG0542	response to heat
BKM66_RS09255	COG4463	regulation of RNA biosynthetic process
BKM66_RS09270	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BKM66_RS09300	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BKM66_RS09305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BKM66_RS09310	COG0492	ferredoxin-NADP+ reductase activity
BKM66_RS09315	COG0564	pseudouridine synthase activity
BKM66_RS09320	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BKM66_RS09350	COG1564	THIamine pyrophosphokinase
BKM66_RS09360	COG1162	GTPase activity
BKM66_RS09370	COG4988	ABC transporter
BKM66_RS09400	COG4115	mRNA cleavage
BKM66_RS09425	COG0084	hydrolase, TatD family'
BKM66_RS09435	COG1847	R3H domain protein
BKM66_RS09445	COG0594	ribonuclease P activity
BKM66_RS09450	COG0165	Argininosuccinate lyase
BKM66_RS09455	COG0137	argininosuccinate synthase activity
BKM66_RS09465	COG1827	regulation of RNA biosynthetic process
BKM66_RS09480	COG2040	homocysteine
BKM66_RS09485	COG0833	amino acid
BKM66_RS09540	COG0756	dUTP diphosphatase activity
BKM66_RS09555	COG1132	(ABC) transporter
BKM66_RS09560	COG1132	(ABC) transporter
BKM66_RS09570	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BKM66_RS09575	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BKM66_RS09580	COG0705	Rhomboid family
BKM66_RS09585	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BKM66_RS09590	COG1473	amidohydrolase
BKM66_RS09595	COG2171	N-acyltransferase activity
BKM66_RS09605	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BKM66_RS09620	COG1442	glycosyl transferase family 8
BKM66_RS09645	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BKM66_RS09670	COG3623	hexulose-6-phosphate isomerase
BKM66_RS09695	COG1523	belongs to the glycosyl hydrolase 13 family
BKM66_RS09700	COG1609	Transcriptional regulator
BKM66_RS09705	COG1126	abc transporter atp-binding protein
BKM66_RS09710	COG0765	amino acid transport
BKM66_RS09715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BKM66_RS09720	COG3942	CHAP domain
BKM66_RS09730	COG3590	peptidase
BKM66_RS09735	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BKM66_RS09740	COG1321	iron dependent repressor
BKM66_RS09740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BKM66_RS09745	COG1121	(ABC) transporter
BKM66_RS09760	COG0803	Belongs to the bacterial solute-binding protein 9 family
BKM66_RS09780	COG1490	D-aminoacyl-tRNA deacylase activity
BKM66_RS09790	COG0737	Belongs to the 5'-nucleotidase family
BKM66_RS09800	COG1811	Na channel or pump
BKM66_RS09805	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BKM66_RS09830	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BKM66_RS09870	COG1328	CTP reductase activity
BKM66_RS09875	COG1126	abc transporter atp-binding protein
BKM66_RS09885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BKM66_RS09890	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BKM66_RS09910	COG1438	arginine binding
BKM66_RS09915	COG0018	arginyl-trna synthetase
BKM66_RS09935	COG1640	4-alpha-glucanotransferase
BKM66_RS09940	COG2182	Extracellular solute-binding protein
BKM66_RS09945	COG1175	transmembrane transport
BKM66_RS09950	COG3833	ABC-type maltose transport systems, permease component
BKM66_RS09955	COG5521	maltodextrose utilization protein MalA
BKM66_RS09960	COG1609	Transcriptional regulator
BKM66_RS09965	COG1523	belongs to the glycosyl hydrolase 13 family
BKM66_RS09970	COG1780	Probably involved in ribonucleotide reductase function
BKM66_RS09975	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BKM66_RS09980	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BKM66_RS09985	COG2153	protein acetylation
BKM66_RS09995	COG1216	Glycosyl transferase, family 2
BKM66_RS10000	COG1472	Belongs to the glycosyl hydrolase 3 family
BKM66_RS10090	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BKM66_RS10100	COG0305	Participates in initiation and elongation during chromosome replication
BKM66_RS10105	COG0359	binds to the 23S rRNA
BKM66_RS10115	COG0445	tRNA wobble uridine modification
BKM66_RS10130	COG1051	belongs to the nudix hydrolase family
BKM66_RS10135	COG1733	regulation of RNA biosynthetic process
BKM66_RS10145	COG0482	sulfurtransferase activity
BKM66_RS10150	COG1760	l-serine dehydratase
BKM66_RS10155	COG1760	l-serine dehydratase
BKM66_RS10165	COG0745	RESPONSE REGULATOR receiver
BKM66_RS10170	COG3850	Histidine kinase
BKM66_RS10170	COG5002	protein histidine kinase activity
BKM66_RS10180	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BKM66_RS10185	COG1122	ATPase activity
BKM66_RS10190	COG1122	ATPase activity
BKM66_RS10195	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BKM66_RS10200	COG1426	Protein conserved in bacteria
BKM66_RS10205	COG0612	Peptidase, M16
BKM66_RS10210	COG0612	Peptidase, M16
BKM66_RS10220	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BKM66_RS10225	COG0516	GMP reductase activity
BKM66_RS10225	COG0517	IMP dehydrogenase activity
BKM66_RS10235	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BKM66_RS10240	COG0488	(ABC) transporter
BKM66_RS10300	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BKM66_RS10305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BKM66_RS10310	COG1475	DNA binding