locus-tag	class	description
NOV99_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NOV99_RS00010	COG0592	DNA-directed DNA polymerase activity
NOV99_RS00030	COG0012	GTP binding
NOV99_RS00035	COG0193	aminoacyl-tRNA hydrolase activity
NOV99_RS00040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NOV99_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NOV99_RS00065	COG0037	tRNA processing
NOV99_RS00075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NOV99_RS00185	COG1792	Involved in formation and maintenance of cell shape
NOV99_RS00200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NOV99_RS00205	COG0436	Aminotransferase
NOV99_RS00210	COG1381	Involved in DNA repair and RecF pathway recombination
NOV99_RS00215	COG0416	fatty acid biosynthetic process
NOV99_RS00220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NOV99_RS00230	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NOV99_RS00245	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NOV99_RS00250	COG0138	bifunctional purine biosynthesis protein purh
NOV99_RS00275	COG0151	Belongs to the GarS family
NOV99_RS00280	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NOV99_RS00295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NOV99_RS00325	COG1131	(ABC) transporter
NOV99_RS00335	COG1132	(ABC) transporter
NOV99_RS00345	COG2255	four-way junction helicase activity
NOV99_RS00355	COG0546	phosphoglycolate phosphatase activity
NOV99_RS00370	COG0285	dihydrofolate synthase activity
NOV99_RS00385	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NOV99_RS00390	COG0632	four-way junction helicase activity
NOV99_RS00395	COG0519	Catalyzes the synthesis of GMP from XMP
NOV99_RS00410	COG1393	Belongs to the ArsC family
NOV99_RS00415	COG4472	Bacterial protein of unknown function (DUF965)
NOV99_RS00420	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NOV99_RS00425	COG3906	Belongs to the UPF0473 family
NOV99_RS00440	COG0051	transcription antitermination factor activity, RNA binding
NOV99_RS00445	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NOV99_RS00450	COG0088	Forms part of the polypeptide exit tunnel
NOV99_RS00455	COG0089	rRNA binding
NOV99_RS00460	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NOV99_RS00465	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NOV99_RS00470	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NOV99_RS00475	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NOV99_RS00480	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NOV99_RS00485	COG0255	Belongs to the universal ribosomal protein uL29 family
NOV99_RS00490	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NOV99_RS00495	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NOV99_RS00500	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NOV99_RS00505	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NOV99_RS00510	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NOV99_RS00515	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NOV99_RS00520	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NOV99_RS00525	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NOV99_RS00530	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NOV99_RS00535	COG1841	ribosomal large subunit assembly
NOV99_RS00545	COG0201	protein transport
NOV99_RS00550	COG0563	adenylate kinase activity
NOV99_RS00555	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NOV99_RS00560	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NOV99_RS00565	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NOV99_RS00575	COG0202	RNA polymerase activity
NOV99_RS00670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NOV99_RS00680	COG3557	Belongs to the UPF0374 family
NOV99_RS00690	COG2188	Transcriptional regulator
NOV99_RS00695	COG2188	Transcriptional regulator
NOV99_RS00705	COG3716	PTS system mannose fructose sorbose family IID component
NOV99_RS00715	COG2017	converts alpha-aldose to the beta-anomer
NOV99_RS00730	COG0346	lactoylglutathione lyase activity
NOV99_RS00765	COG0494	nUDIX hydrolase
NOV99_RS00780	COG1217	gtp-binding protein TYPA
NOV99_RS00795	COG0681	Belongs to the peptidase S26 family
NOV99_RS00820	COG0242	peptide deformylase activity
NOV99_RS00830	COG1640	4-alpha-glucanotransferase
NOV99_RS00835	COG0058	SHG alpha-glucan phosphorylase activity
NOV99_RS00855	COG1263	PTS System
NOV99_RS00855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NOV99_RS00855	COG2190	(PTS) system
NOV99_RS00870	COG0217	transcriptional regulatory protein
NOV99_RS00880	COG4720	Psort location CytoplasmicMembrane, score
NOV99_RS00890	COG1054	Belongs to the UPF0176 family
NOV99_RS00900	COG1122	ATPase activity
NOV99_RS00920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NOV99_RS00925	COG3331	DNA recombination
NOV99_RS00930	COG4474	Belongs to the UPF0398 family
NOV99_RS00935	COG3599	regulation of cell shape
NOV99_RS00945	COG0116	Belongs to the methyltransferase superfamily
NOV99_RS00955	COG1854	S-ribosylhomocysteine lyase activity
NOV99_RS00960	COG1418	mRNA catabolic process
NOV99_RS00970	COG1758	RNA polymerase activity
NOV99_RS00975	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NOV99_RS00980	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NOV99_RS00985	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NOV99_RS00985	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NOV99_RS00990	COG0631	protein serine/threonine phosphatase activity
NOV99_RS00995	COG0515	serine threonine protein kinase
NOV99_RS00995	COG2815	serine threonine protein kinase
NOV99_RS01010	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NOV99_RS01015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NOV99_RS01030	COG1126	abc transporter atp-binding protein
NOV99_RS01035	COG1328	CTP reductase activity
NOV99_RS01045	COG0737	Belongs to the 5'-nucleotidase family
NOV99_RS01070	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NOV99_RS01090	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NOV99_RS01110	COG0737	Belongs to the 5'-nucleotidase family
NOV99_RS01120	COG1490	D-aminoacyl-tRNA deacylase activity
NOV99_RS01135	COG0803	Belongs to the bacterial solute-binding protein 9 family
NOV99_RS01145	COG1121	(ABC) transporter
NOV99_RS01150	COG1321	iron dependent repressor
NOV99_RS01150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NOV99_RS01155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NOV99_RS01160	COG3590	peptidase
NOV99_RS01170	COG1486	melibiose metabolic process
NOV99_RS01175	COG2723	6-phospho-beta-galactosidase activity
NOV99_RS01185	COG3711	transcriptional antiterminator
NOV99_RS01185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NOV99_RS01195	COG1447	Phosphotransferase system cellobiose-specific component IIA
NOV99_RS01205	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NOV99_RS01210	COG3942	CHAP domain
NOV99_RS01215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NOV99_RS01220	COG0765	amino acid transport
NOV99_RS01225	COG1126	abc transporter atp-binding protein
NOV99_RS01230	COG1609	Transcriptional regulator
NOV99_RS01235	COG1523	belongs to the glycosyl hydrolase 13 family
NOV99_RS01260	COG3623	hexulose-6-phosphate isomerase
NOV99_RS01285	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NOV99_RS01310	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NOV99_RS01320	COG2171	N-acyltransferase activity
NOV99_RS01325	COG1473	amidohydrolase
NOV99_RS01330	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NOV99_RS01335	COG0705	Rhomboid family
NOV99_RS01340	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NOV99_RS01345	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NOV99_RS01355	COG1132	(ABC) transporter
NOV99_RS01360	COG1132	(ABC) transporter
NOV99_RS01365	COG0756	dUTP diphosphatase activity
NOV99_RS01420	COG1827	regulation of RNA biosynthetic process
NOV99_RS01430	COG0137	argininosuccinate synthase activity
NOV99_RS01435	COG0165	Argininosuccinate lyase
NOV99_RS01440	COG0594	ribonuclease P activity
NOV99_RS01450	COG1847	R3H domain protein
NOV99_RS01460	COG0084	hydrolase, TatD family'
NOV99_RS01485	COG4115	mRNA cleavage
NOV99_RS01520	COG1132	(ABC) transporter
NOV99_RS01525	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NOV99_RS01540	COG1162	GTPase activity
NOV99_RS01550	COG1564	THIamine pyrophosphokinase
NOV99_RS01570	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NOV99_RS01615	COG0564	pseudouridine synthase activity
NOV99_RS01620	COG0492	ferredoxin-NADP+ reductase activity
NOV99_RS01625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NOV99_RS01630	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NOV99_RS01665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NOV99_RS01670	COG3022	response to hydroperoxide
NOV99_RS01675	COG1316	TRANSCRIPTIONal
NOV99_RS01680	COG3944	biosynthesis protein
NOV99_RS01690	COG4464	protein tyrosine phosphatase activity
NOV99_RS01705	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
NOV99_RS01710	COG3475	LICD family
NOV99_RS01715	COG1215	transferase activity, transferring glycosyl groups
NOV99_RS01725	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NOV99_RS01740	COG0562	UDP-galactopyranose mutase
NOV99_RS01745	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NOV99_RS01760	COG0436	Aminotransferase
NOV99_RS01775	COG0534	Mate efflux family protein
NOV99_RS01785	COG0251	oxidation-reduction process
NOV99_RS01790	COG1660	Displays ATPase and GTPase activities
NOV99_RS01795	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NOV99_RS01800	COG1481	regulation of sporulation
NOV99_RS01815	COG0454	-acetyltransferase
NOV99_RS01820	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NOV99_RS01825	COG0549	Belongs to the carbamate kinase family
NOV99_RS01830	COG1288	antiporter activity
NOV99_RS01835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NOV99_RS01850	COG1438	arginine binding
NOV99_RS01855	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NOV99_RS01860	COG0363	glucosamine-6-phosphate deaminase activity
NOV99_RS01880	COG0463	Glycosyl transferase, family 2
NOV99_RS01925	COG1696	Membrane protein involved in D-alanine export
NOV99_RS01930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NOV99_RS01935	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
NOV99_RS01945	COG0435	Glutathione S-transferase
NOV99_RS01950	COG1187	pseudouridine synthase activity
NOV99_RS01955	COG0386	Belongs to the glutathione peroxidase family
NOV99_RS01960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NOV99_RS01965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NOV99_RS01970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NOV99_RS01975	COG1120	ATPase activity
NOV99_RS01980	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NOV99_RS01985	COG0204	Acyl-transferase
NOV99_RS01990	COG1555	photosystem II stabilization
NOV99_RS01990	COG1596	polysaccharide export
NOV99_RS01995	COG2333	competence protein COMEC
NOV99_RS01995	COG0658	competence protein
NOV99_RS02005	COG0517	IMP dehydrogenase activity
NOV99_RS02020	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NOV99_RS02025	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NOV99_RS02030	COG0470	DNA polymerase III
NOV99_RS02035	COG4467	Involved in initiation control of chromosome replication
NOV99_RS02045	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NOV99_RS02055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NOV99_RS02060	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NOV99_RS02065	COG1393	Belongs to the ArsC family
NOV99_RS02075	COG0708	Exodeoxyribonuclease III
NOV99_RS02085	COG0531	amino acid
NOV99_RS02115	COG1061	Type III restriction enzyme res subunit
NOV99_RS02120	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NOV99_RS02140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NOV99_RS02145	COG4684	Psort location CytoplasmicMembrane, score
NOV99_RS02150	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NOV99_RS02160	COG2759	Belongs to the formate--tetrahydrofolate ligase family
NOV99_RS02205	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NOV99_RS02210	COG1349	DNA-binding transcription factor activity
NOV99_RS02220	COG1447	Phosphotransferase system cellobiose-specific component IIA
NOV99_RS02225	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NOV99_RS02230	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NOV99_RS02235	COG1882	Formate acetyltransferase
NOV99_RS02255	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NOV99_RS02260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NOV99_RS02275	COG1164	Oligoendopeptidase f
NOV99_RS02290	COG0210	DNA helicase
NOV99_RS02335	COG1131	(ABC) transporter
NOV99_RS02340	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NOV99_RS02350	COG1185	polyribonucleotide nucleotidyltransferase activity
NOV99_RS02355	COG1045	serine acetyltransferase
NOV99_RS02375	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
NOV99_RS02385	COG3842	ATPase activity
NOV99_RS02400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NOV99_RS02415	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NOV99_RS02465	COG2151	metal-sulfur cluster biosynthetic enzyme
NOV99_RS02475	COG0129	dihydroxy-acid dehydratase activity
NOV99_RS02490	COG0463	Glycosyl transferase, family 2
NOV99_RS02495	COG0028	Belongs to the TPP enzyme family
NOV99_RS02500	COG0440	acetolactate synthase activity
NOV99_RS02505	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NOV99_RS02510	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NOV99_RS02530	COG0765	amino acid transport
NOV99_RS02535	COG1968	undecaprenyl-diphosphatase activity
NOV99_RS02540	COG4862	establishment of competence for transformation
NOV99_RS02545	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NOV99_RS02555	COG0719	Fe-S assembly protein
NOV99_RS02560	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NOV99_RS02575	COG1686	Belongs to the peptidase S11 family
NOV99_RS02580	COG0747	negative chemotaxis
NOV99_RS02590	COG4608	Belongs to the ABC transporter superfamily
NOV99_RS02595	COG0601	transmembrane transport
NOV99_RS02600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NOV99_RS02620	COG0802	atpase or kinase
NOV99_RS02630	COG1316	TRANSCRIPTIONal
NOV99_RS02640	COG0537	adenosine 5'-monophosphoramidase activity
NOV99_RS02645	COG1131	(ABC) transporter
NOV99_RS02650	COG4473	ABC transporter
NOV99_RS02660	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NOV99_RS02670	COG0195	Participates in both transcription termination and antitermination
NOV99_RS02675	COG2740	Nucleic-acid-binding protein implicated in transcription termination
NOV99_RS02685	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NOV99_RS02690	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NOV99_RS02705	COG2860	membrane
NOV99_RS02710	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NOV99_RS02715	COG0508	dehydrogenase complex catalyzes the overall conversion of
NOV99_RS02715	COG0022	dehydrogenase e1 component
NOV99_RS02720	COG0508	dehydrogenase complex catalyzes the overall conversion of
NOV99_RS02740	COG2190	(PTS) system
NOV99_RS02740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NOV99_RS02740	COG1263	PTS System
NOV99_RS02755	COG2207	Transcriptional regulator
NOV99_RS02760	COG2723	6-phospho-beta-galactosidase activity
NOV99_RS02765	COG0346	lactoylglutathione lyase activity
NOV99_RS02770	COG2723	6-phospho-beta-galactosidase activity
NOV99_RS02775	COG4095	Psort location CytoplasmicMembrane, score
NOV99_RS02795	COG1447	Phosphotransferase system cellobiose-specific component IIA
NOV99_RS02805	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NOV99_RS02810	COG2723	6-phospho-beta-galactosidase activity
NOV99_RS02825	COG2723	6-phospho-beta-galactosidase activity
NOV99_RS02830	COG0095	Lipoate-protein ligase
NOV99_RS02840	COG0629	single-stranded DNA binding
NOV99_RS02845	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NOV99_RS02860	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NOV99_RS02865	COG0006	proline dipeptidase activity
NOV99_RS02880	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NOV99_RS02885	COG1609	Transcriptional regulator
NOV99_RS02890	COG1621	beta-fructofuranosidase activity
NOV99_RS02895	COG1263	PTS System
NOV99_RS02895	COG2190	(PTS) system
NOV99_RS02895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NOV99_RS02900	COG1940	carbohydrate kinase activity
NOV99_RS02910	COG0653	protein targeting
NOV99_RS02915	COG0736	holo-[acyl-carrier-protein] synthase activity
NOV99_RS02920	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NOV99_RS02925	COG0527	aspartate kinase activity
NOV99_RS02930	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NOV99_RS02935	COG1024	Enoyl-CoA hydratase
NOV99_RS02945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NOV99_RS02955	COG2070	2-Nitropropane dioxygenase
NOV99_RS02960	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NOV99_RS02965	COG1028	Short-chain dehydrogenase reductase Sdr
NOV99_RS02985	COG0439	Biotin carboxylase
NOV99_RS03025	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
NOV99_RS03035	COG3177	Filamentation induced by cAMP protein fic
NOV99_RS03060	COG3716	PTS system mannose fructose sorbose family IID component
NOV99_RS03065	COG3715	PTS system
NOV99_RS03075	COG0561	phosphatase activity
NOV99_RS03080	COG2252	PERMEase
NOV99_RS03090	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NOV99_RS03095	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NOV99_RS03100	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NOV99_RS03105	COG1464	Belongs to the NlpA lipoprotein family
NOV99_RS03110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NOV99_RS03115	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NOV99_RS03140	COG0751	glycine-tRNA ligase activity
NOV99_RS03145	COG4224	UPF0291 protein
NOV99_RS03155	COG0534	Mate efflux family protein
NOV99_RS03160	COG0569	domain protein
NOV99_RS03165	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NOV99_RS03175	COG1252	NADH dehydrogenase
NOV99_RS03180	COG0142	geranyltranstransferase activity
NOV99_RS03185	COG4939	FMN-binding domain protein
NOV99_RS03230	COG0275	rRNA processing
NOV99_RS03240	COG0768	penicillin binding
NOV99_RS03245	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NOV99_RS03265	COG0513	Belongs to the DEAD box helicase family
NOV99_RS03275	COG0492	ferredoxin-NADP+ reductase activity
NOV99_RS03285	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NOV99_RS03290	COG0745	RESPONSE REGULATOR receiver
NOV99_RS03300	COG0628	permease
NOV99_RS03305	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NOV99_RS03315	COG1484	DNA-dependent DNA replication
NOV99_RS03325	COG1160	GTP binding
NOV99_RS03335	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NOV99_RS03345	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NOV99_RS03360	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NOV99_RS03365	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NOV99_RS03370	COG0706	membrane insertase activity
NOV99_RS03375	COG1254	Belongs to the acylphosphatase family
NOV99_RS03380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NOV99_RS03395	COG3579	cysteine-type endopeptidase activity
NOV99_RS03405	COG3763	UPF0154 protein
NOV99_RS03410	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NOV99_RS03430	COG0582	viral genome integration into host DNA
NOV99_RS03435	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NOV99_RS03440	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NOV99_RS03445	COG1187	pseudouridine synthase activity
NOV99_RS03450	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NOV99_RS03465	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
NOV99_RS03470	COG0671	phosphoesterase, PA-phosphatase related
NOV99_RS03475	COG2755	lipolytic protein G-D-S-L family
NOV99_RS03475	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NOV99_RS03485	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NOV99_RS03510	COG2827	Endonuclease containing a URI domain
NOV99_RS03515	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NOV99_RS03535	COG2195	Cleaves the N-terminal amino acid of tripeptides
NOV99_RS03540	COG0561	phosphatase activity
NOV99_RS03580	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NOV99_RS03585	COG0196	riboflavin kinase activity
NOV99_RS03590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NOV99_RS03595	COG1393	Belongs to the ArsC family
NOV99_RS03600	COG4476	Belongs to the UPF0223 family
NOV99_RS03605	COG0483	inositol monophosphate 1-phosphatase activity
NOV99_RS03610	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
NOV99_RS03610	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NOV99_RS03620	COG0573	inorganic phosphate transmembrane transporter activity
NOV99_RS03625	COG0581	inorganic phosphate transmembrane transporter activity
NOV99_RS03630	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NOV99_RS03635	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NOV99_RS03640	COG0704	Plays a role in the regulation of phosphate uptake
NOV99_RS03655	COG0745	RESPONSE REGULATOR receiver
NOV99_RS03660	COG5002	protein histidine kinase activity
NOV99_RS03670	COG0268	Binds directly to 16S ribosomal RNA
NOV99_RS03675	COG1072	(Pantothenic acid kinase))
NOV99_RS03680	COG2813	Specifically methylates the guanine in position
NOV99_RS03685	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
NOV99_RS03700	COG1744	ABC transporter substrate-binding protein PnrA-like
NOV99_RS03705	COG3845	ABC transporter
NOV99_RS03710	COG4603	Belongs to the binding-protein-dependent transport system permease family
NOV99_RS03715	COG1079	Belongs to the binding-protein-dependent transport system permease family
NOV99_RS03720	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NOV99_RS03730	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NOV99_RS03735	COG0039	L-malate dehydrogenase activity
NOV99_RS03740	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NOV99_RS03745	COG3764	Sortase (surface protein transpeptidase)
NOV99_RS03755	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NOV99_RS03760	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
NOV99_RS03775	COG1104	cysteine desulfurase activity
NOV99_RS03785	COG4116	CYTH
NOV99_RS03790	COG2357	RelA SpoT domain protein
NOV99_RS03795	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NOV99_RS03800	COG0564	pseudouridine synthase activity
NOV99_RS03805	COG0280	phosphate acetyltransferase
NOV99_RS03810	COG1132	(ABC) transporter
NOV99_RS03815	COG1132	(ABC) transporter
NOV99_RS03825	COG1194	a g-specific adenine glycosylase
NOV99_RS03835	COG1396	sequence-specific DNA binding
NOV99_RS03865	COG1349	DNA-binding transcription factor activity
NOV99_RS03870	COG0698	ribose 5-phosphate isomerase
NOV99_RS03875	COG0698	ribose 5-phosphate isomerase
NOV99_RS03880	COG1105	Belongs to the carbohydrate kinase PfkB family
NOV99_RS03885	COG3684	Belongs to the aldolase LacD family
NOV99_RS03890	COG3711	transcriptional antiterminator
NOV99_RS03900	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NOV99_RS03900	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NOV99_RS03940	COG1070	Carbohydrate kinase
NOV99_RS03960	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NOV99_RS03970	COG3716	PTS system mannose fructose sorbose family IID component
NOV99_RS04060	COG0488	(ABC) transporter
NOV99_RS04070	COG1126	abc transporter atp-binding protein
NOV99_RS04095	COG3583	domain protein
NOV99_RS04110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NOV99_RS04125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NOV99_RS04140	COG0297	glycogen (starch) synthase activity
NOV99_RS04165	COG0167	dihydroorotate dehydrogenase activity
NOV99_RS04170	COG0284	orotidine-5'-phosphate decarboxylase activity
NOV99_RS04175	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NOV99_RS04185	COG0463	Glycosyl transferase, family 2
NOV99_RS04190	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NOV99_RS04200	COG0737	Belongs to the 5'-nucleotidase family
NOV99_RS04205	COG0424	maF-like protein
NOV99_RS04215	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NOV99_RS04220	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NOV99_RS04230	COG1272	protein, Hemolysin III
NOV99_RS04240	COG0446	pyridine nucleotide-disulphide oxidoreductase
NOV99_RS04250	COG1937	Protein conserved in bacteria
NOV99_RS04255	COG0110	maltose O-acetyltransferase activity
NOV99_RS04260	COG0758	DNA mediated transformation
NOV99_RS04265	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NOV99_RS04270	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NOV99_RS04275	COG0222	ribosome binding
NOV99_RS04280	COG0647	UMP catabolic process
NOV99_RS04285	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
NOV99_RS04290	COG2207	Transcriptional regulator
NOV99_RS04290	COG3708	Transcriptional regulator
NOV99_RS04300	COG2382	esterase
NOV99_RS04335	COG1136	(ABC) transporter
NOV99_RS04355	COG0745	RESPONSE REGULATOR receiver
NOV99_RS04370	COG4974	Belongs to the 'phage' integrase family
NOV99_RS04375	COG1660	Displays ATPase and GTPase activities
NOV99_RS04390	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NOV99_RS04395	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
NOV99_RS04400	COG2188	Transcriptional regulator
NOV99_RS04410	COG4268	DNA restriction-modification system
NOV99_RS04415	COG1401	restriction endodeoxyribonuclease activity
NOV99_RS04440	COG4221	oxidoreductase activity
NOV99_RS04445	COG0741	lytic transglycosylase activity
NOV99_RS04455	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NOV99_RS04465	COG0009	L-threonylcarbamoyladenylate synthase
NOV99_RS04470	COG2890	protein-(glutamine-N5) methyltransferase activity
NOV99_RS04475	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NOV99_RS04495	COG0481	GTPase activity
NOV99_RS04510	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NOV99_RS04515	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NOV99_RS04520	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NOV99_RS04535	COG1940	carbohydrate kinase activity
NOV99_RS04545	COG0488	(ABC) transporter
NOV99_RS04550	COG0617	tRNA 3'-terminal CCA addition
NOV99_RS04555	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NOV99_RS04560	COG1307	EDD domain protein, DegV family
NOV99_RS04570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NOV99_RS04570	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NOV99_RS04570	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NOV99_RS04575	COG1105	Belongs to the carbohydrate kinase PfkB family
NOV99_RS04580	COG1349	DNA-binding transcription factor activity
NOV99_RS04585	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NOV99_RS04590	COG0336	Belongs to the RNA methyltransferase TrmD family
NOV99_RS04595	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NOV99_RS04600	COG0534	Mate efflux family protein
NOV99_RS04610	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NOV99_RS04615	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NOV99_RS04630	COG0038	chloride channel
NOV99_RS04640	COG1177	transmembrane transport
NOV99_RS04645	COG1176	ABC-type spermidine putrescine transport system, permease component I
NOV99_RS04650	COG3842	ATPase activity
NOV99_RS04655	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NOV99_RS04665	COG0083	homoserine kinase activity
NOV99_RS04675	COG0726	polysaccharide deacetylase
NOV99_RS04680	COG1132	(ABC) transporter
NOV99_RS04695	COG0228	four-way junction DNA binding
NOV99_RS04705	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
NOV99_RS04710	COG2136	Putative SAM-dependent methyltransferase
NOV99_RS04710	COG2521	methyltransferase
NOV99_RS04720	COG0505	Belongs to the CarA family
NOV99_RS04725	COG0540	Belongs to the ATCase OTCase family
NOV99_RS04730	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NOV99_RS04740	COG2824	Alkylphosphonate utilization operon protein PhnA
NOV99_RS04745	COG0564	pseudouridine synthase activity
NOV99_RS04770	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NOV99_RS04775	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NOV99_RS04780	COG1114	Component of the transport system for branched-chain amino acids
NOV99_RS04785	COG0301	tRNA thio-modification
NOV99_RS04790	COG1104	cysteine desulfurase activity
NOV99_RS04815	COG0539	negative regulation of cytoplasmic translation
NOV99_RS04840	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NOV99_RS04845	COG1956	GAF domain-containing protein
NOV99_RS04865	COG0673	inositol 2-dehydrogenase activity
NOV99_RS04870	COG0513	Belongs to the DEAD box helicase family
NOV99_RS04875	COG0726	polysaccharide deacetylase
NOV99_RS04890	COG0183	Belongs to the thiolase family
NOV99_RS04895	COG3425	synthase
NOV99_RS04920	COG0776	regulation of translation
NOV99_RS04930	COG2755	lipolytic protein G-D-S-L family
NOV99_RS04935	COG1307	EDD domain protein, DegV family
NOV99_RS04940	COG0497	DNA recombination
NOV99_RS04945	COG1438	arginine binding
NOV99_RS04950	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
NOV99_RS04960	COG1722	exodeoxyribonuclease VII activity
NOV99_RS04965	COG1570	exodeoxyribonuclease VII activity
NOV99_RS04970	COG2321	neutral zinc metallopeptidase
NOV99_RS04975	COG1755	Isoprenylcysteine carboxyl methyltransferase
NOV99_RS04980	COG5002	protein histidine kinase activity
NOV99_RS04985	COG0745	RESPONSE REGULATOR receiver
NOV99_RS05010	COG1227	inorganic diphosphatase activity
NOV99_RS05020	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NOV99_RS05025	COG1253	flavin adenine dinucleotide binding
NOV99_RS05030	COG1119	ATPase activity
NOV99_RS05035	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
NOV99_RS05040	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NOV99_RS05045	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NOV99_RS05050	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NOV99_RS05065	COG4470	Protein conserved in bacteria
NOV99_RS05070	COG3480	Lon protease (S16) C-terminal proteolytic domain
NOV99_RS05075	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NOV99_RS05080	COG0742	ribosomal rna small subunit methyltransferase
NOV99_RS05090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NOV99_RS05095	COG4483	Protein conserved in bacteria
NOV99_RS05100	COG2197	response regulator
NOV99_RS05105	COG2203	Gaf domain
NOV99_RS05105	COG4585	Histidine kinase
NOV99_RS05110	COG0842	Transport permease protein
NOV99_RS05115	COG1131	(ABC) transporter
NOV99_RS05135	COG3716	PTS system mannose fructose sorbose family IID component
NOV99_RS05145	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NOV99_RS05150	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NOV99_RS05175	COG1028	Short-chain dehydrogenase reductase Sdr
NOV99_RS05210	COG1476	TRANSCRIPTIONal
NOV99_RS05230	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NOV99_RS05240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NOV99_RS05245	COG4122	O-methyltransferase activity
NOV99_RS05270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NOV99_RS05270	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NOV99_RS05280	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NOV99_RS05285	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NOV99_RS05290	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NOV99_RS05295	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NOV99_RS05300	COG1116	anion transmembrane transporter activity
NOV99_RS05300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NOV99_RS05305	COG4120	Belongs to the binding-protein-dependent transport system permease family
NOV99_RS05320	COG3684	Belongs to the aldolase LacD family
NOV99_RS05335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NOV99_RS05340	COG1126	abc transporter atp-binding protein
NOV99_RS05345	COG0765	amino acid transport
NOV99_RS05350	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NOV99_RS05365	COG2755	lipolytic protein G-D-S-L family
NOV99_RS05365	COG0657	acetylesterase activity
NOV99_RS05370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NOV99_RS05385	COG0469	pyruvate kinase activity
NOV99_RS05390	COG0205	6-phosphofructokinase activity
NOV99_RS05400	COG2188	Transcriptional regulator
NOV99_RS05405	COG1131	(ABC) transporter
NOV99_RS05415	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NOV99_RS05635	COG3723	Recombinational DNA repair protein, rece pathway
NOV99_RS05695	COG3561	AntA/AntB antirepressor
NOV99_RS05705	COG1396	sequence-specific DNA binding
NOV99_RS05755	COG2151	metal-sulfur cluster biosynthetic enzyme
NOV99_RS05760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NOV99_RS05765	COG0358	DNA primase activity
NOV99_RS05770	COG1970	mechanosensitive ion channel activity
NOV99_RS05775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NOV99_RS05780	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NOV99_RS05790	COG0647	UMP catabolic process
NOV99_RS05795	COG1051	belongs to the nudix hydrolase family
NOV99_RS05805	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NOV99_RS05815	COG0058	SHG alpha-glucan phosphorylase activity
NOV99_RS05820	COG0813	purine-nucleoside phosphorylase activity
NOV99_RS05825	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NOV99_RS05835	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
NOV99_RS05840	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
NOV99_RS05855	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NOV99_RS05870	COG2268	Band 7 protein
NOV99_RS05875	COG1704	LemA family
NOV99_RS05885	COG1573	uracil-dna glycosylase
NOV99_RS05905	COG2226	methyltransferase
NOV99_RS05910	COG0488	(ABC) transporter
NOV99_RS05915	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NOV99_RS05930	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NOV99_RS05935	COG3442	glutamine amidotransferase
NOV99_RS05940	COG2226	methyltransferase
NOV99_RS05950	COG0488	(ABC) transporter
NOV99_RS05985	COG3842	ATPase activity
NOV99_RS06005	COG2190	(PTS) system
NOV99_RS06005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NOV99_RS06005	COG1263	PTS System
NOV99_RS06010	COG3711	transcriptional antiterminator
NOV99_RS06015	COG1293	RNA-binding protein homologous to eukaryotic snRNP
NOV99_RS06020	COG3527	Alpha-acetolactate decarboxylase
NOV99_RS06030	COG0628	permease
NOV99_RS06035	COG2706	6-phosphogluconolactonase activity
NOV99_RS06045	COG1011	Hydrolase
NOV99_RS06070	COG1929	Belongs to the glycerate kinase type-1 family
NOV99_RS06100	COG0560	Phosphoserine phosphatase
NOV99_RS06110	COG0187	DNA topoisomerase II activity
NOV99_RS06115	COG0693	protein deglycase activity
NOV99_RS06120	COG0772	Belongs to the SEDS family
NOV99_RS06140	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NOV99_RS06145	COG0716	FMN binding
NOV99_RS06155	COG1605	Chorismate mutase
NOV99_RS06155	COG0287	Prephenate dehydrogenase
NOV99_RS06160	COG0038	chloride channel
NOV99_RS06170	COG0737	Belongs to the 5'-nucleotidase family
NOV99_RS06175	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NOV99_RS06180	COG1466	dna polymerase III delta subunit
NOV99_RS06215	COG0683	leucine binding
NOV99_RS06230	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NOV99_RS06235	COG0366	Alpha amylase catalytic
NOV99_RS06245	COG0395	ABC-type sugar transport system, permease component
NOV99_RS06250	COG1175	transmembrane transport
NOV99_RS06255	COG1653	transport
NOV99_RS06265	COG2207	Transcriptional regulator
NOV99_RS06270	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NOV99_RS06275	COG0626	cystathionine gamma-synthase activity
NOV99_RS06295	COG3547	Transposase (IS116 IS110 IS902 family)
NOV99_RS06315	COG1695	Transcriptional regulator
NOV99_RS06340	COG3759	membrane
NOV99_RS06345	COG1846	Transcriptional regulator
NOV99_RS06370	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NOV99_RS06380	COG2610	gluconate transmembrane transporter activity
NOV99_RS06400	COG0302	gtp cyclohydrolase
NOV99_RS06405	COG1051	belongs to the nudix hydrolase family
NOV99_RS06435	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NOV99_RS06435	COG0072	phenylalanine-tRNA ligase activity
NOV99_RS06465	COG1028	Short-chain dehydrogenase reductase Sdr
NOV99_RS06480	COG0800	Aldolase
NOV99_RS06490	COG3250	beta-galactosidase activity
NOV99_RS06515	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NOV99_RS06525	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NOV99_RS06530	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NOV99_RS06535	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NOV99_RS06540	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NOV99_RS06545	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NOV99_RS06550	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NOV99_RS06555	COG0356	it plays a direct role in the translocation of protons across the membrane
NOV99_RS06565	COG1597	lipid kinase activity
NOV99_RS06580	COG0701	Predicted permease
NOV99_RS06585	COG3689	TIGRFAM TIGR03943 family protein
NOV99_RS06590	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NOV99_RS06605	COG0552	protein localization to endoplasmic reticulum
NOV99_RS06610	COG0561	phosphatase activity
NOV99_RS06615	COG0561	phosphatase activity
NOV99_RS06620	COG1196	nuclear chromosome segregation
NOV99_RS06655	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NOV99_RS06660	COG0538	isocitrate dehydrogenase activity
NOV99_RS06665	COG0372	Belongs to the citrate synthase family
NOV99_RS06670	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NOV99_RS06675	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NOV99_RS06680	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NOV99_RS06685	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NOV99_RS06690	COG1609	Transcriptional regulator
NOV99_RS06725	COG0640	Transcriptional regulator
NOV99_RS06730	COG0513	Belongs to the DEAD box helicase family
NOV99_RS06735	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NOV99_RS06785	COG0494	nUDIX hydrolase
NOV99_RS06790	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NOV99_RS06800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NOV99_RS06805	COG1028	Short-chain dehydrogenase reductase Sdr
NOV99_RS06830	COG0577	efflux transmembrane transporter activity
NOV99_RS06835	COG1136	(ABC) transporter
NOV99_RS06840	COG2205	protein histidine kinase activity
NOV99_RS06855	COG0436	Aminotransferase
NOV99_RS06865	COG1174	glycine betaine transport
NOV99_RS06870	COG0517	IMP dehydrogenase activity
NOV99_RS06870	COG1125	glycine betaine transport
NOV99_RS06890	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NOV99_RS06895	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
NOV99_RS06900	COG1482	cell wall glycoprotein biosynthetic process
NOV99_RS06915	COG3091	SprT-like family
NOV99_RS06920	COG2183	response to ionizing radiation
NOV99_RS06940	COG0656	L-ascorbic acid biosynthetic process
NOV99_RS06945	COG4708	membrane
NOV99_RS06950	COG2246	polysaccharide biosynthetic process
NOV99_RS06960	COG0024	Methionine aminopeptidase
NOV99_RS06970	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NOV99_RS06975	COG2249	NAD(P)H dehydrogenase (quinone) activity
NOV99_RS06985	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NOV99_RS06990	COG2131	deaminase
NOV99_RS07000	COG1363	Peptidase, m42
NOV99_RS07020	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NOV99_RS07030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NOV99_RS07045	COG2184	nucleotidyltransferase activity
NOV99_RS07050	COG0187	DNA topoisomerase II activity
NOV99_RS07060	COG1074	ATP-dependent DNA helicase activity
NOV99_RS07065	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
NOV99_RS07095	COG1131	(ABC) transporter
NOV99_RS07125	COG1832	CoA-binding protein
NOV99_RS07135	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NOV99_RS07135	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NOV99_RS07145	COG3547	Transposase (IS116 IS110 IS902 family)
NOV99_RS07155	COG1136	(ABC) transporter
NOV99_RS07165	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
NOV99_RS07170	COG2217	Heavy metal translocating P-type atpase
NOV99_RS07185	COG1063	alcohol dehydrogenase
NOV99_RS07190	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NOV99_RS07195	COG0557	exoribonuclease II activity
NOV99_RS07205	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NOV99_RS07210	COG2814	Major facilitator Superfamily
NOV99_RS07215	COG0237	dephospho-CoA kinase activity
NOV99_RS07220	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NOV99_RS07225	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NOV99_RS07230	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NOV99_RS07240	COG1737	Transcriptional regulator
NOV99_RS07260	COG1011	Hydrolase
NOV99_RS07265	COG1132	(ABC) transporter
NOV99_RS07270	COG1132	(ABC) transporter
NOV99_RS07295	COG2177	Part of the ABC transporter FtsEX involved in
NOV99_RS07300	COG2884	Cell division ATP-binding protein ftsE
NOV99_RS07310	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NOV99_RS07350	COG1078	dGTPase activity
NOV99_RS07380	COG1187	pseudouridine synthase activity
NOV99_RS07395	COG0242	peptide deformylase activity
NOV99_RS07405	COG0066	3-isopropylmalate dehydratase activity
NOV99_RS07430	COG2309	aminopeptidase activity
NOV99_RS07445	COG2176	DNA-directed DNA polymerase activity
NOV99_RS07450	COG2376	Dihydroxyacetone kinase
NOV99_RS07465	COG2376	Dihydroxyacetone kinase
NOV99_RS07470	COG1461	Dihydroxyacetone kinase
NOV99_RS07475	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
NOV99_RS07480	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NOV99_RS07485	COG0442	prolyl-tRNA aminoacylation
NOV99_RS07495	COG4589	Belongs to the CDS family
NOV99_RS07500	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NOV99_RS07505	COG1862	Preprotein translocase
NOV99_RS07515	COG2918	glutathione biosynthetic process
NOV99_RS07515	COG1181	Belongs to the D-alanine--D-alanine ligase family
NOV99_RS07525	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NOV99_RS07530	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NOV99_RS07550	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NOV99_RS07555	COG0542	response to heat
NOV99_RS07560	COG4463	regulation of RNA biosynthetic process
NOV99_RS07575	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NOV99_RS07595	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NOV99_RS07600	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NOV99_RS07605	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NOV99_RS07635	COG3679	Belongs to the UPF0342 family
NOV99_RS07640	COG0287	Prephenate dehydrogenase
NOV99_RS07645	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NOV99_RS07650	COG0710	3-dehydroquinate dehydratase activity
NOV99_RS07655	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NOV99_RS07660	COG1368	sulfuric ester hydrolase activity
NOV99_RS07675	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NOV99_RS07685	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NOV99_RS07715	COG1216	Glycosyl transferase, family 2
NOV99_RS07730	COG1216	Glycosyl transferase, family 2
NOV99_RS07730	COG1442	glycosyl transferase family 8
NOV99_RS07735	COG1442	glycosyl transferase family 8
NOV99_RS07765	COG1216	Glycosyl transferase, family 2
NOV99_RS07765	COG1442	glycosyl transferase family 8
NOV99_RS07795	COG1091	dTDP-4-dehydrorhamnose reductase activity
NOV99_RS07800	COG1088	dTDP-glucose 4,6-dehydratase activity
NOV99_RS07815	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NOV99_RS07825	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NOV99_RS07830	COG2384	SAM-dependent methyltransferase
NOV99_RS07845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NOV99_RS07855	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
NOV99_RS07855	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NOV99_RS07860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NOV99_RS07870	COG0300	oxidoreductase activity
NOV99_RS07875	COG1234	tRNA 3'-trailer cleavage
NOV99_RS07885	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NOV99_RS07890	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NOV99_RS07900	COG2807	transmembrane transport
NOV99_RS07905	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NOV99_RS07920	COG1702	phosphate starvation-inducible protein PhoH
NOV99_RS07930	COG4479	Belongs to the UPF0346 family
NOV99_RS07945	COG2996	Protein conserved in bacteria
NOV99_RS07950	COG0233	cytoplasmic translational termination
NOV99_RS07955	COG0528	UMP kinase activity
NOV99_RS07960	COG2244	polysaccharide biosynthetic process
NOV99_RS07965	COG0625	glutathione transferase activity
NOV99_RS07990	COG0346	lactoylglutathione lyase activity
NOV99_RS07995	COG1674	ftsk spoiiie
NOV99_RS07995	COG0697	spore germination
NOV99_RS08005	COG1653	transport
NOV99_RS08010	COG0395	ABC-type sugar transport system, permease component
NOV99_RS08015	COG4209	transmembrane transport
NOV99_RS08020	COG1609	Transcriptional regulator
NOV99_RS08040	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NOV99_RS08050	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NOV99_RS08060	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NOV99_RS08080	COG1181	Belongs to the D-alanine--D-alanine ligase family
NOV99_RS08085	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NOV99_RS08090	COG0768	penicillin binding
NOV99_RS08095	COG0488	(ABC) transporter
NOV99_RS08105	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NOV99_RS08115	COG0745	RESPONSE REGULATOR receiver
NOV99_RS08125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NOV99_RS08130	COG0765	amino acid transport
NOV99_RS08135	COG0765	amino acid transport
NOV99_RS08140	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NOV99_RS08155	COG0438	transferase activity, transferring glycosyl groups
NOV99_RS08170	COG1609	Transcriptional regulator
NOV99_RS08180	COG0343	queuine tRNA-ribosyltransferase activity
NOV99_RS08200	COG0149	triose-phosphate isomerase activity
NOV99_RS08205	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NOV99_RS08220	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NOV99_RS08225	COG0772	Belongs to the SEDS family
NOV99_RS08245	COG3859	Proton-coupled thiamine transporter YuaJ
NOV99_RS08255	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NOV99_RS08265	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NOV99_RS08305	COG0577	efflux transmembrane transporter activity
NOV99_RS08310	COG1136	(ABC) transporter
NOV99_RS08315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NOV99_RS08330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NOV99_RS08340	COG1268	BioY protein
NOV99_RS08345	COG4443	Transcriptional Coactivator p15 (PC4)
NOV99_RS08360	COG0826	peptidase U32
NOV99_RS08375	COG0789	Transcriptional regulator
NOV99_RS08410	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NOV99_RS08420	COG0765	amino acid transport
NOV99_RS08425	COG4703	Protein of unknown function (DUF1797)
NOV99_RS08430	COG0542	response to heat
NOV99_RS08435	COG0406	alpha-ribazole phosphatase activity
NOV99_RS08435	COG0494	nUDIX hydrolase
NOV99_RS08465	COG3599	regulation of cell shape
NOV99_RS08480	COG1799	cell septum assembly
NOV99_RS08485	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NOV99_RS08490	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NOV99_RS08505	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NOV99_RS08590	COG2226	methyltransferase
NOV99_RS08595	COG0799	negative regulation of ribosome biogenesis
NOV99_RS08610	COG1713	HD superfamily hydrolase involved in NAD metabolism
NOV99_RS08615	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NOV99_RS08620	COG1534	Rna-binding protein
NOV99_RS08625	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NOV99_RS08640	COG3142	Participates in the control of copper homeostasis
NOV99_RS08655	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
NOV99_RS08660	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NOV99_RS08665	COG1609	Transcriptional regulator
NOV99_RS08675	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NOV99_RS08680	COG0154	amidase activity
NOV99_RS08685	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NOV99_RS08695	COG0335	large ribosomal subunit rRNA binding
NOV99_RS08705	COG1335	isochorismatase
NOV99_RS08710	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
NOV99_RS08715	COG0436	Aminotransferase
NOV99_RS08745	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NOV99_RS08780	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NOV99_RS08785	COG0191	fructose-bisphosphate aldolase activity
NOV99_RS08795	COG0504	CTP synthase activity
NOV99_RS08800	COG3343	RNA polymerase activity
NOV99_RS08830	COG0544	peptidyl-prolyl cis-trans isomerase activity
NOV99_RS08850	COG1902	pentaerythritol trinitrate reductase activity
NOV99_RS08850	COG0446	pyridine nucleotide-disulphide oxidoreductase
NOV99_RS08855	COG4221	oxidoreductase activity
NOV99_RS08880	COG4475	Protein of unknown function (DUF436)
NOV99_RS08905	COG2217	Heavy metal translocating P-type atpase
NOV99_RS08915	COG3655	Transcriptional regulator
NOV99_RS08930	COG0765	amino acid transport
NOV99_RS08935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NOV99_RS08945	COG0095	Lipoate-protein ligase
NOV99_RS08950	COG0484	heat shock protein binding
NOV99_RS08955	COG0443	Heat shock 70 kDa protein
NOV99_RS08960	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NOV99_RS08965	COG1420	regulation of RNA biosynthetic process
NOV99_RS08970	COG0588	phosphoglycerate mutase activity
NOV99_RS08975	COG2848	UPF0210 protein
NOV99_RS08980	COG3830	Belongs to the UPF0237 family
NOV99_RS08985	COG1132	(ABC) transporter
NOV99_RS08990	COG1132	(ABC) transporter
NOV99_RS08995	COG1304	FMN binding
NOV99_RS09010	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NOV99_RS09015	COG0534	Mate efflux family protein
NOV99_RS09020	COG1129	ABC transporter
NOV99_RS09035	COG1132	(ABC) transporter
NOV99_RS09055	COG1454	alcohol dehydrogenase
NOV99_RS09055	COG1012	belongs to the aldehyde dehydrogenase family
NOV99_RS09060	COG1064	alcohol dehydrogenase
NOV99_RS09065	COG0124	histidyl-tRNA synthetase
NOV99_RS09075	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NOV99_RS09080	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NOV99_RS09105	COG0494	nUDIX hydrolase
NOV99_RS09110	COG0433	COG0433 Predicted ATPase
NOV99_RS09115	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NOV99_RS09120	COG2116	formate transmembrane transporter activity
NOV99_RS09125	COG1346	cytolysis
NOV99_RS09130	COG1380	Effector of murein hydrolase LrgA
NOV99_RS09150	COG1511	domain protein
NOV99_RS09155	COG1309	transcriptional regulator
NOV99_RS09160	COG1131	(ABC) transporter
NOV99_RS09175	COG0561	phosphatase activity
NOV99_RS09180	COG2843	Capsule synthesis protein
NOV99_RS09185	COG0167	dihydroorotate dehydrogenase activity
NOV99_RS09190	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NOV99_RS09200	COG0668	transmembrane transport
NOV99_RS09210	COG2188	Transcriptional regulator
NOV99_RS09225	COG1193	negative regulation of DNA recombination
NOV99_RS09250	COG3118	belongs to the thioredoxin family
NOV99_RS09260	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NOV99_RS09260	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NOV99_RS09320	COG1115	amino acid carrier protein
NOV99_RS09340	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NOV99_RS09345	COG0077	Prephenate dehydratase
NOV99_RS09355	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NOV99_RS09370	COG0270	DNA (cytosine-5-)-methyltransferase activity
NOV99_RS09535	COG1475	DNA binding
NOV99_RS09540	COG4443	Transcriptional Coactivator p15 (PC4)
NOV99_RS09575	COG1192	Involved in chromosome partitioning
NOV99_RS09605	COG1396	sequence-specific DNA binding
NOV99_RS09610	COG0542	response to heat
NOV99_RS09615	COG0613	PHP domain protein
NOV99_RS09630	COG3843	relaxase mobilization nuclease domain protein
NOV99_RS09650	COG1131	(ABC) transporter
NOV99_RS09685	COG0562	UDP-galactopyranose mutase
NOV99_RS09700	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NOV99_RS09715	COG0436	Aminotransferase
NOV99_RS09750	COG0366	Alpha amylase catalytic
NOV99_RS09770	COG0681	Belongs to the peptidase S26 family
NOV99_RS09775	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NOV99_RS09780	COG2217	Heavy metal translocating P-type atpase
NOV99_RS09795	COG2217	Heavy metal translocating P-type atpase
NOV99_RS09800	COG2217	Heavy metal translocating P-type atpase
NOV99_RS09805	COG0363	glucosamine-6-phosphate deaminase activity
NOV99_RS09840	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NOV99_RS09865	COG2910	NAD(P)H-binding
NOV99_RS09880	COG1882	Formate acetyltransferase
NOV99_RS09885	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NOV99_RS09915	COG2222	sugar isomerase
NOV99_RS09920	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NOV99_RS09925	COG0584	glycerophosphoryl diester phosphodiesterase
NOV99_RS09930	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NOV99_RS09935	COG3959	Transketolase, thiamine diphosphate binding domain
NOV99_RS09950	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NOV99_RS09960	COG2723	6-phospho-beta-galactosidase activity
NOV99_RS09965	COG2081	HI0933 family
NOV99_RS09975	COG1131	(ABC) transporter
NOV99_RS09985	COG2855	membrane
NOV99_RS10005	COG0395	ABC-type sugar transport system, permease component
NOV99_RS10010	COG1175	transmembrane transport
NOV99_RS10020	COG2207	Transcriptional regulator
NOV99_RS10025	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NOV99_RS10035	COG1214	PFAM Peptidase M22, glycoprotease
NOV99_RS10050	COG0174	glutamine synthetase
NOV99_RS10055	COG0789	Transcriptional regulator
NOV99_RS10065	COG0126	phosphoglycerate kinase activity
NOV99_RS10075	COG3590	peptidase
NOV99_RS10080	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NOV99_RS10085	COG0049	tRNA binding
NOV99_RS10095	COG0459	protein refolding
NOV99_RS10120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NOV99_RS10130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NOV99_RS10140	COG1363	Peptidase, m42
NOV99_RS10145	COG0285	dihydrofolate synthase activity
NOV99_RS10155	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NOV99_RS10185	COG4537	Required for transformation and DNA binding
NOV99_RS10190	COG1459	type II secretion system
NOV99_RS10195	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NOV99_RS10200	COG1619	proteins homologs of microcin C7 resistance protein MccF
NOV99_RS10210	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NOV99_RS10215	COG0085	RNA polymerase activity
NOV99_RS10220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NOV99_RS10250	COG0803	Belongs to the bacterial solute-binding protein 9 family
NOV99_RS10250	COG3443	Belongs to the bacterial solute-binding protein 9 family
NOV99_RS10255	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NOV99_RS10260	COG1121	(ABC) transporter
NOV99_RS10295	COG1674	ftsk spoiiie
NOV99_RS10305	COG2946	Replication initiation factor
NOV99_RS10315	COG0582	viral genome integration into host DNA
NOV99_RS10405	COG1739	Uncharacterized protein family UPF0029
NOV99_RS10410	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
NOV99_RS10545	COG2369	cell adhesion
NOV99_RS10620	COG0556	nucleotide-excision repair
NOV99_RS10700	COG4974	Belongs to the 'phage' integrase family
NOV99_RS10710	COG1098	S1 RNA binding domain
NOV99_RS10750	COG1438	arginine binding
NOV99_RS10755	COG0018	arginyl-trna synthetase
NOV99_RS10775	COG1640	4-alpha-glucanotransferase
NOV99_RS10780	COG2182	Extracellular solute-binding protein
NOV99_RS10785	COG1175	transmembrane transport
NOV99_RS10790	COG3833	ABC-type maltose transport systems, permease component
NOV99_RS10795	COG5521	maltodextrose utilization protein MalA
NOV99_RS10800	COG1609	Transcriptional regulator
NOV99_RS10805	COG1523	belongs to the glycosyl hydrolase 13 family
NOV99_RS10810	COG1780	Probably involved in ribonucleotide reductase function
NOV99_RS10815	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NOV99_RS10820	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NOV99_RS10825	COG2153	protein acetylation
NOV99_RS10830	COG4989	oxidoreductase activity
NOV99_RS10835	COG1216	Glycosyl transferase, family 2
NOV99_RS10855	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NOV99_RS10865	COG0305	Participates in initiation and elongation during chromosome replication
NOV99_RS10870	COG0359	binds to the 23S rRNA
NOV99_RS10880	COG0445	tRNA wobble uridine modification
NOV99_RS10885	COG0494	nUDIX hydrolase
NOV99_RS10890	COG1733	regulation of RNA biosynthetic process
NOV99_RS10900	COG0482	sulfurtransferase activity
NOV99_RS10905	COG1760	l-serine dehydratase
NOV99_RS10910	COG1760	l-serine dehydratase
NOV99_RS10920	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NOV99_RS10925	COG1122	ATPase activity
NOV99_RS10930	COG1122	ATPase activity
NOV99_RS10935	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NOV99_RS10940	COG1426	Protein conserved in bacteria
NOV99_RS10945	COG0612	Peptidase, M16
NOV99_RS10950	COG0612	Peptidase, M16
NOV99_RS10960	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NOV99_RS10970	COG0516	GMP reductase activity
NOV99_RS10970	COG0517	IMP dehydrogenase activity
NOV99_RS10980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NOV99_RS10985	COG0488	(ABC) transporter
NOV99_RS11015	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NOV99_RS11020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NOV99_RS11025	COG1475	DNA binding