locus-tag	class	description
SSUD12_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SSUD12_RS00010	COG0592	DNA-directed DNA polymerase activity
SSUD12_RS00030	COG0012	GTP binding
SSUD12_RS00035	COG0193	aminoacyl-tRNA hydrolase activity
SSUD12_RS00040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SSUD12_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SSUD12_RS00065	COG0037	tRNA processing
SSUD12_RS00185	COG1792	Involved in formation and maintenance of cell shape
SSUD12_RS00200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SSUD12_RS00205	COG0436	Aminotransferase
SSUD12_RS00210	COG1381	Involved in DNA repair and RecF pathway recombination
SSUD12_RS00215	COG0416	fatty acid biosynthetic process
SSUD12_RS00220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SSUD12_RS00245	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SSUD12_RS00255	COG0138	bifunctional purine biosynthesis protein purh
SSUD12_RS00280	COG0151	Belongs to the GarS family
SSUD12_RS00285	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SSUD12_RS00305	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SSUD12_RS00325	COG1131	(ABC) transporter
SSUD12_RS00335	COG1132	(ABC) transporter
SSUD12_RS00340	COG2255	four-way junction helicase activity
SSUD12_RS00350	COG0546	phosphoglycolate phosphatase activity
SSUD12_RS00365	COG0285	dihydrofolate synthase activity
SSUD12_RS00380	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SSUD12_RS00385	COG0632	four-way junction helicase activity
SSUD12_RS00390	COG0519	Catalyzes the synthesis of GMP from XMP
SSUD12_RS00415	COG1393	Belongs to the ArsC family
SSUD12_RS00420	COG4472	Bacterial protein of unknown function (DUF965)
SSUD12_RS00425	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SSUD12_RS00430	COG3906	Belongs to the UPF0473 family
SSUD12_RS00435	COG0051	transcription antitermination factor activity, RNA binding
SSUD12_RS00440	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SSUD12_RS00445	COG0088	Forms part of the polypeptide exit tunnel
SSUD12_RS00450	COG0089	rRNA binding
SSUD12_RS00455	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SSUD12_RS00460	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SSUD12_RS00465	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SSUD12_RS00470	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SSUD12_RS00475	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SSUD12_RS00480	COG0255	Belongs to the universal ribosomal protein uL29 family
SSUD12_RS00485	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SSUD12_RS00490	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SSUD12_RS00495	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SSUD12_RS00500	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SSUD12_RS00505	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SSUD12_RS00510	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SSUD12_RS00520	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SSUD12_RS00525	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SSUD12_RS00530	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SSUD12_RS00535	COG1841	ribosomal large subunit assembly
SSUD12_RS00545	COG0201	protein transport
SSUD12_RS00550	COG0563	adenylate kinase activity
SSUD12_RS00555	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SSUD12_RS00560	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SSUD12_RS00565	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SSUD12_RS00575	COG0202	RNA polymerase activity
SSUD12_RS00685	COG1121	(ABC) transporter
SSUD12_RS00690	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SSUD12_RS00695	COG3443	Belongs to the bacterial solute-binding protein 9 family
SSUD12_RS00695	COG0803	Belongs to the bacterial solute-binding protein 9 family
SSUD12_RS00745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SSUD12_RS00750	COG0085	RNA polymerase activity
SSUD12_RS00755	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SSUD12_RS00765	COG1619	proteins homologs of microcin C7 resistance protein MccF
SSUD12_RS00770	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SSUD12_RS00775	COG1459	type II secretion system
SSUD12_RS00780	COG4537	Required for transformation and DNA binding
SSUD12_RS00810	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SSUD12_RS00825	COG1363	Peptidase, m42
SSUD12_RS00835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SSUD12_RS00845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SSUD12_RS00870	COG0459	protein refolding
SSUD12_RS00880	COG0049	tRNA binding
SSUD12_RS00885	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SSUD12_RS00915	COG0126	phosphoglycerate kinase activity
SSUD12_RS00925	COG0789	Transcriptional regulator
SSUD12_RS00930	COG0174	glutamine synthetase
SSUD12_RS00955	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SSUD12_RS00960	COG2207	Transcriptional regulator
SSUD12_RS00970	COG1175	transmembrane transport
SSUD12_RS00975	COG0395	ABC-type sugar transport system, permease component
SSUD12_RS00995	COG2855	membrane
SSUD12_RS01005	COG1131	(ABC) transporter
SSUD12_RS01015	COG2081	HI0933 family
SSUD12_RS01020	COG2723	6-phospho-beta-galactosidase activity
SSUD12_RS01030	COG0584	glycerophosphoryl diester phosphodiesterase
SSUD12_RS01035	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SSUD12_RS01040	COG2222	sugar isomerase
SSUD12_RS01065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SSUD12_RS01075	COG3942	CHAP domain
SSUD12_RS01080	COG1882	Formate acetyltransferase
SSUD12_RS01095	COG2910	NAD(P)H-binding
SSUD12_RS01110	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SSUD12_RS01115	COG0681	Belongs to the peptidase S26 family
SSUD12_RS01140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SSUD12_RS01140	COG1263	PTS System
SSUD12_RS01155	COG2188	Transcriptional regulator
SSUD12_RS01170	COG1193	negative regulation of DNA recombination
SSUD12_RS01215	COG3118	belongs to the thioredoxin family
SSUD12_RS01220	COG0318	PFAM AMP-dependent synthetase and ligase
SSUD12_RS01225	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SSUD12_RS01225	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SSUD12_RS01255	COG1115	amino acid carrier protein
SSUD12_RS01260	COG0668	transmembrane transport
SSUD12_RS01275	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SSUD12_RS01285	COG0167	dihydroorotate dehydrogenase activity
SSUD12_RS01290	COG2843	Capsule synthesis protein
SSUD12_RS01295	COG0561	phosphatase activity
SSUD12_RS01310	COG1131	(ABC) transporter
SSUD12_RS01315	COG1309	transcriptional regulator
SSUD12_RS01320	COG1511	domain protein
SSUD12_RS01345	COG0433	COG0433 Predicted ATPase
SSUD12_RS01350	COG0494	nUDIX hydrolase
SSUD12_RS01385	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SSUD12_RS01390	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SSUD12_RS01395	COG0124	histidyl-tRNA synthetase
SSUD12_RS01400	COG1064	alcohol dehydrogenase
SSUD12_RS01405	COG1454	alcohol dehydrogenase
SSUD12_RS01405	COG1012	belongs to the aldehyde dehydrogenase family
SSUD12_RS01415	COG4988	ABC transporter
SSUD12_RS01420	COG1132	(ABC) transporter
SSUD12_RS01435	COG1129	ABC transporter
SSUD12_RS01440	COG0534	Mate efflux family protein
SSUD12_RS01445	COG1132	(ABC) transporter
SSUD12_RS01455	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SSUD12_RS01470	COG1304	FMN binding
SSUD12_RS01475	COG1132	(ABC) transporter
SSUD12_RS01480	COG1132	(ABC) transporter
SSUD12_RS01485	COG3830	Belongs to the UPF0237 family
SSUD12_RS01490	COG2848	UPF0210 protein
SSUD12_RS01495	COG0588	phosphoglycerate mutase activity
SSUD12_RS01510	COG1396	sequence-specific DNA binding
SSUD12_RS01520	COG1695	Transcriptional regulator
SSUD12_RS01530	COG1420	regulation of RNA biosynthetic process
SSUD12_RS01535	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SSUD12_RS01540	COG0443	Heat shock 70 kDa protein
SSUD12_RS01550	COG0484	heat shock protein binding
SSUD12_RS01555	COG0095	Lipoate-protein ligase
SSUD12_RS01565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SSUD12_RS01570	COG0765	amino acid transport
SSUD12_RS01575	COG3655	Transcriptional regulator
SSUD12_RS01585	COG2217	Heavy metal translocating P-type atpase
SSUD12_RS01610	COG4475	Protein of unknown function (DUF436)
SSUD12_RS01645	COG4221	oxidoreductase activity
SSUD12_RS01650	COG0446	pyridine nucleotide-disulphide oxidoreductase
SSUD12_RS01650	COG1902	pentaerythritol trinitrate reductase activity
SSUD12_RS01670	COG2910	NAD(P)H-binding
SSUD12_RS01675	COG1959	2 iron, 2 sulfur cluster binding
SSUD12_RS01680	COG1309	transcriptional regulator
SSUD12_RS01695	COG0544	peptidyl-prolyl cis-trans isomerase activity
SSUD12_RS01725	COG3343	RNA polymerase activity
SSUD12_RS01730	COG0504	CTP synthase activity
SSUD12_RS01740	COG0191	fructose-bisphosphate aldolase activity
SSUD12_RS01745	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SSUD12_RS01785	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SSUD12_RS01810	COG0589	response to stress
SSUD12_RS01815	COG0436	Aminotransferase
SSUD12_RS01820	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SSUD12_RS01825	COG1335	isochorismatase
SSUD12_RS01830	COG0335	large ribosomal subunit rRNA binding
SSUD12_RS01845	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SSUD12_RS01850	COG0154	amidase activity
SSUD12_RS01855	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SSUD12_RS01860	COG1609	Transcriptional regulator
SSUD12_RS01865	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SSUD12_RS01870	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SSUD12_RS01880	COG3142	Participates in the control of copper homeostasis
SSUD12_RS01895	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SSUD12_RS01900	COG1534	Rna-binding protein
SSUD12_RS01905	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SSUD12_RS01910	COG1713	HD superfamily hydrolase involved in NAD metabolism
SSUD12_RS01925	COG1335	isochorismatase
SSUD12_RS01930	COG0799	negative regulation of ribosome biogenesis
SSUD12_RS01935	COG2226	methyltransferase
SSUD12_RS01950	COG2348	transferase activity, transferring amino-acyl groups
SSUD12_RS01960	COG0242	peptide deformylase activity
SSUD12_RS01970	COG1640	4-alpha-glucanotransferase
SSUD12_RS01975	COG0058	SHG alpha-glucan phosphorylase activity
SSUD12_RS01990	COG1263	PTS System
SSUD12_RS01990	COG2190	(PTS) system
SSUD12_RS01990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SSUD12_RS02005	COG0217	transcriptional regulatory protein
SSUD12_RS02020	COG4720	Psort location CytoplasmicMembrane, score
SSUD12_RS02030	COG1054	Belongs to the UPF0176 family
SSUD12_RS02040	COG1122	ATPase activity
SSUD12_RS02055	COG0357	Ribosomal RNA small subunit methyltransferase G
SSUD12_RS02060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SSUD12_RS02065	COG3331	DNA recombination
SSUD12_RS02070	COG4474	Belongs to the UPF0398 family
SSUD12_RS02075	COG3599	regulation of cell shape
SSUD12_RS02080	COG0116	Belongs to the methyltransferase superfamily
SSUD12_RS02090	COG1854	S-ribosylhomocysteine lyase activity
SSUD12_RS02095	COG1418	mRNA catabolic process
SSUD12_RS02105	COG1758	RNA polymerase activity
SSUD12_RS02110	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SSUD12_RS02115	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SSUD12_RS02120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SSUD12_RS02120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SSUD12_RS02125	COG0631	protein serine/threonine phosphatase activity
SSUD12_RS02130	COG0515	serine threonine protein kinase
SSUD12_RS02130	COG2815	serine threonine protein kinase
SSUD12_RS02155	COG1098	S1 RNA binding domain
SSUD12_RS02165	COG1739	Uncharacterized protein family UPF0029
SSUD12_RS02170	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SSUD12_RS02265	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SSUD12_RS02275	COG3557	Belongs to the UPF0374 family
SSUD12_RS02285	COG2188	Transcriptional regulator
SSUD12_RS02300	COG2188	Transcriptional regulator
SSUD12_RS02310	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SSUD12_RS02320	COG3716	PTS system mannose fructose sorbose family IID component
SSUD12_RS02330	COG2017	converts alpha-aldose to the beta-anomer
SSUD12_RS02345	COG0346	lactoylglutathione lyase activity
SSUD12_RS02360	COG0525	valine-tRNA ligase activity
SSUD12_RS02395	COG1217	gtp-binding protein TYPA
SSUD12_RS02410	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SSUD12_RS02425	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SSUD12_RS02430	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SSUD12_RS02435	COG1799	cell septum assembly
SSUD12_RS02450	COG3599	regulation of cell shape
SSUD12_RS02470	COG0494	nUDIX hydrolase
SSUD12_RS02470	COG0406	alpha-ribazole phosphatase activity
SSUD12_RS02475	COG0542	response to heat
SSUD12_RS02480	COG4703	Protein of unknown function (DUF1797)
SSUD12_RS02485	COG0765	amino acid transport
SSUD12_RS02495	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SSUD12_RS02530	COG0789	Transcriptional regulator
SSUD12_RS02545	COG0826	peptidase U32
SSUD12_RS02555	COG4443	Transcriptional Coactivator p15 (PC4)
SSUD12_RS02560	COG1268	BioY protein
SSUD12_RS02565	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
SSUD12_RS02570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SSUD12_RS02575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SSUD12_RS02580	COG1136	(ABC) transporter
SSUD12_RS02585	COG0577	efflux transmembrane transporter activity
SSUD12_RS02680	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SSUD12_RS02690	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SSUD12_RS02700	COG3859	Proton-coupled thiamine transporter YuaJ
SSUD12_RS02720	COG0772	Belongs to the SEDS family
SSUD12_RS02725	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SSUD12_RS02740	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SSUD12_RS02745	COG0149	triose-phosphate isomerase activity
SSUD12_RS02755	COG1078	dGTPase activity
SSUD12_RS02790	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SSUD12_RS02800	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SSUD12_RS02805	COG2884	Cell division ATP-binding protein ftsE
SSUD12_RS02810	COG2177	Part of the ABC transporter FtsEX involved in
SSUD12_RS02835	COG1132	(ABC) transporter
SSUD12_RS02840	COG1132	(ABC) transporter
SSUD12_RS02845	COG1011	Hydrolase
SSUD12_RS02865	COG1737	Transcriptional regulator
SSUD12_RS02875	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SSUD12_RS02880	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SSUD12_RS02890	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SSUD12_RS02900	COG2814	Major facilitator Superfamily
SSUD12_RS02905	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SSUD12_RS02915	COG0557	exoribonuclease II activity
SSUD12_RS02920	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SSUD12_RS02940	COG1129	ABC transporter
SSUD12_RS02960	COG1063	alcohol dehydrogenase
SSUD12_RS02975	COG2217	Heavy metal translocating P-type atpase
SSUD12_RS02980	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SSUD12_RS02990	COG1136	(ABC) transporter
SSUD12_RS03015	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SSUD12_RS03015	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SSUD12_RS03025	COG1832	CoA-binding protein
SSUD12_RS03040	COG0343	queuine tRNA-ribosyltransferase activity
SSUD12_RS03055	COG1609	Transcriptional regulator
SSUD12_RS03070	COG0438	transferase activity, transferring glycosyl groups
SSUD12_RS03085	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SSUD12_RS03090	COG0765	amino acid transport
SSUD12_RS03095	COG0765	amino acid transport
SSUD12_RS03100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SSUD12_RS03110	COG0745	RESPONSE REGULATOR receiver
SSUD12_RS03120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SSUD12_RS03130	COG0768	penicillin binding
SSUD12_RS03135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SSUD12_RS03140	COG1181	Belongs to the D-alanine--D-alanine ligase family
SSUD12_RS03160	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SSUD12_RS03170	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SSUD12_RS03180	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SSUD12_RS03200	COG1609	Transcriptional regulator
SSUD12_RS03205	COG4209	transmembrane transport
SSUD12_RS03210	COG0395	ABC-type sugar transport system, permease component
SSUD12_RS03215	COG1653	transport
SSUD12_RS03225	COG1674	ftsk spoiiie
SSUD12_RS03225	COG0697	spore germination
SSUD12_RS03230	COG0346	lactoylglutathione lyase activity
SSUD12_RS03255	COG0625	glutathione transferase activity
SSUD12_RS03260	COG2244	polysaccharide biosynthetic process
SSUD12_RS03265	COG0528	UMP kinase activity
SSUD12_RS03270	COG0233	cytoplasmic translational termination
SSUD12_RS03275	COG2996	Protein conserved in bacteria
SSUD12_RS03290	COG4479	Belongs to the UPF0346 family
SSUD12_RS03295	COG1702	phosphate starvation-inducible protein PhoH
SSUD12_RS03300	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SSUD12_RS03305	COG2807	transmembrane transport
SSUD12_RS03320	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SSUD12_RS03325	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SSUD12_RS03335	COG1234	tRNA 3'-trailer cleavage
SSUD12_RS03340	COG0300	oxidoreductase activity
SSUD12_RS03345	COG2217	Heavy metal translocating P-type atpase
SSUD12_RS03350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SSUD12_RS03355	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SSUD12_RS03355	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SSUD12_RS03365	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SSUD12_RS03380	COG2384	SAM-dependent methyltransferase
SSUD12_RS03385	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SSUD12_RS03395	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SSUD12_RS03415	COG1088	dTDP-glucose 4,6-dehydratase activity
SSUD12_RS03420	COG1091	dTDP-4-dehydrorhamnose reductase activity
SSUD12_RS03455	COG1216	Glycosyl transferase, family 2
SSUD12_RS03455	COG1442	glycosyl transferase family 8
SSUD12_RS03485	COG1442	glycosyl transferase family 8
SSUD12_RS03490	COG1442	glycosyl transferase family 8
SSUD12_RS03490	COG1216	Glycosyl transferase, family 2
SSUD12_RS03505	COG1216	Glycosyl transferase, family 2
SSUD12_RS03535	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SSUD12_RS03545	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SSUD12_RS03560	COG1368	sulfuric ester hydrolase activity
SSUD12_RS03565	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SSUD12_RS03570	COG0710	3-dehydroquinate dehydratase activity
SSUD12_RS03575	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SSUD12_RS03580	COG0287	Prephenate dehydrogenase
SSUD12_RS03585	COG3679	Belongs to the UPF0342 family
SSUD12_RS03595	COG3684	Belongs to the aldolase LacD family
SSUD12_RS03615	COG4120	Belongs to the binding-protein-dependent transport system permease family
SSUD12_RS03620	COG1116	anion transmembrane transporter activity
SSUD12_RS03620	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SSUD12_RS03625	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SSUD12_RS03630	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SSUD12_RS03635	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SSUD12_RS03640	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SSUD12_RS03650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SSUD12_RS03650	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SSUD12_RS03660	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
SSUD12_RS03665	COG3620	sequence-specific DNA binding
SSUD12_RS03695	COG4122	O-methyltransferase activity
SSUD12_RS03700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SSUD12_RS03710	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SSUD12_RS03730	COG1476	TRANSCRIPTIONal
SSUD12_RS03765	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SSUD12_RS03770	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SSUD12_RS03775	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SSUD12_RS03780	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SSUD12_RS03785	COG0372	Belongs to the citrate synthase family
SSUD12_RS03790	COG0538	isocitrate dehydrogenase activity
SSUD12_RS03795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SSUD12_RS03835	COG1196	nuclear chromosome segregation
SSUD12_RS03840	COG0561	phosphatase activity
SSUD12_RS03845	COG0561	phosphatase activity
SSUD12_RS03850	COG0552	protein localization to endoplasmic reticulum
SSUD12_RS03865	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SSUD12_RS03870	COG3689	TIGRFAM TIGR03943 family protein
SSUD12_RS03875	COG0701	Predicted permease
SSUD12_RS03885	COG1597	lipid kinase activity
SSUD12_RS03895	COG0356	it plays a direct role in the translocation of protons across the membrane
SSUD12_RS03900	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SSUD12_RS03905	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SSUD12_RS03910	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SSUD12_RS03915	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SSUD12_RS03920	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SSUD12_RS03925	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SSUD12_RS03935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SSUD12_RS03950	COG2211	Major facilitator Superfamily
SSUD12_RS03960	COG3250	beta-galactosidase activity
SSUD12_RS03970	COG0800	Aldolase
SSUD12_RS03980	COG1312	Catalyzes the dehydration of D-mannonate
SSUD12_RS03985	COG1028	Short-chain dehydrogenase reductase Sdr
SSUD12_RS04015	COG0072	phenylalanine-tRNA ligase activity
SSUD12_RS04015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SSUD12_RS04040	COG1051	belongs to the nudix hydrolase family
SSUD12_RS04045	COG0302	gtp cyclohydrolase
SSUD12_RS04065	COG2610	gluconate transmembrane transporter activity
SSUD12_RS04070	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SSUD12_RS04085	COG1846	Transcriptional regulator
SSUD12_RS04090	COG3759	membrane
SSUD12_RS04120	COG2195	Cleaves the N-terminal amino acid of tripeptides
SSUD12_RS04125	COG0561	phosphatase activity
SSUD12_RS04160	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SSUD12_RS04165	COG0196	riboflavin kinase activity
SSUD12_RS04170	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SSUD12_RS04175	COG1393	Belongs to the ArsC family
SSUD12_RS04180	COG4476	Belongs to the UPF0223 family
SSUD12_RS04185	COG0483	inositol monophosphate 1-phosphatase activity
SSUD12_RS04190	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SSUD12_RS04190	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SSUD12_RS04200	COG0573	inorganic phosphate transmembrane transporter activity
SSUD12_RS04205	COG0581	inorganic phosphate transmembrane transporter activity
SSUD12_RS04210	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SSUD12_RS04215	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SSUD12_RS04220	COG0704	Plays a role in the regulation of phosphate uptake
SSUD12_RS04230	COG0745	RESPONSE REGULATOR receiver
SSUD12_RS04235	COG5002	protein histidine kinase activity
SSUD12_RS04250	COG1072	(Pantothenic acid kinase))
SSUD12_RS04255	COG2813	Specifically methylates the guanine in position
SSUD12_RS04260	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SSUD12_RS04270	COG0295	cytidine deaminase activity
SSUD12_RS04275	COG1744	ABC transporter substrate-binding protein PnrA-like
SSUD12_RS04280	COG3845	ABC transporter
SSUD12_RS04285	COG4603	Belongs to the binding-protein-dependent transport system permease family
SSUD12_RS04290	COG1079	Belongs to the binding-protein-dependent transport system permease family
SSUD12_RS04295	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SSUD12_RS04300	COG0039	L-malate dehydrogenase activity
SSUD12_RS04305	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SSUD12_RS04310	COG3764	Sortase (surface protein transpeptidase)
SSUD12_RS04320	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SSUD12_RS04325	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SSUD12_RS04340	COG1104	cysteine desulfurase activity
SSUD12_RS04350	COG4116	CYTH
SSUD12_RS04355	COG2357	RelA SpoT domain protein
SSUD12_RS04360	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SSUD12_RS04365	COG0564	pseudouridine synthase activity
SSUD12_RS04370	COG0280	phosphate acetyltransferase
SSUD12_RS04375	COG1132	(ABC) transporter
SSUD12_RS04380	COG1132	(ABC) transporter
SSUD12_RS04390	COG1194	a g-specific adenine glycosylase
SSUD12_RS04395	COG1396	sequence-specific DNA binding
SSUD12_RS04415	COG2873	o-acetylhomoserine
SSUD12_RS04420	COG0488	(ABC) transporter
SSUD12_RS04430	COG1126	abc transporter atp-binding protein
SSUD12_RS04450	COG3583	domain protein
SSUD12_RS04465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SSUD12_RS04470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SSUD12_RS04480	COG0297	glycogen (starch) synthase activity
SSUD12_RS04505	COG0167	dihydroorotate dehydrogenase activity
SSUD12_RS04510	COG0284	orotidine-5'-phosphate decarboxylase activity
SSUD12_RS04515	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SSUD12_RS04525	COG0463	Glycosyl transferase, family 2
SSUD12_RS04530	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SSUD12_RS04540	COG0737	Belongs to the 5'-nucleotidase family
SSUD12_RS04545	COG0424	maF-like protein
SSUD12_RS04555	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SSUD12_RS04560	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SSUD12_RS04570	COG1272	protein, Hemolysin III
SSUD12_RS04580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SSUD12_RS04580	COG0425	Belongs to the sulfur carrier protein TusA family
SSUD12_RS04585	COG0110	maltose O-acetyltransferase activity
SSUD12_RS04590	COG0758	DNA mediated transformation
SSUD12_RS04595	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SSUD12_RS04600	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SSUD12_RS04605	COG0222	ribosome binding
SSUD12_RS04645	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SSUD12_RS04655	COG2382	esterase
SSUD12_RS04685	COG1136	(ABC) transporter
SSUD12_RS04705	COG0745	RESPONSE REGULATOR receiver
SSUD12_RS04710	COG5002	protein histidine kinase activity
SSUD12_RS04720	COG4974	Belongs to the 'phage' integrase family
SSUD12_RS04725	COG1660	Displays ATPase and GTPase activities
SSUD12_RS04740	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SSUD12_RS04745	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
SSUD12_RS04750	COG2188	Transcriptional regulator
SSUD12_RS04760	COG4268	DNA restriction-modification system
SSUD12_RS04765	COG1401	restriction endodeoxyribonuclease activity
SSUD12_RS04790	COG4221	oxidoreductase activity
SSUD12_RS04795	COG0741	lytic transglycosylase activity
SSUD12_RS04805	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SSUD12_RS04815	COG0009	L-threonylcarbamoyladenylate synthase
SSUD12_RS04820	COG2890	protein-(glutamine-N5) methyltransferase activity
SSUD12_RS04825	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SSUD12_RS04850	COG0481	GTPase activity
SSUD12_RS04865	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SSUD12_RS04875	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SSUD12_RS04880	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SSUD12_RS04895	COG1940	carbohydrate kinase activity
SSUD12_RS04905	COG0488	(ABC) transporter
SSUD12_RS04910	COG0617	tRNA 3'-terminal CCA addition
SSUD12_RS04915	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SSUD12_RS04920	COG1307	EDD domain protein, DegV family
SSUD12_RS04930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SSUD12_RS04930	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SSUD12_RS04930	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SSUD12_RS04935	COG1105	Belongs to the carbohydrate kinase PfkB family
SSUD12_RS04940	COG1349	DNA-binding transcription factor activity
SSUD12_RS04945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SSUD12_RS04950	COG0336	Belongs to the RNA methyltransferase TrmD family
SSUD12_RS04955	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SSUD12_RS04960	COG0534	Mate efflux family protein
SSUD12_RS04970	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SSUD12_RS04975	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SSUD12_RS04990	COG1177	transmembrane transport
SSUD12_RS04995	COG1176	ABC-type spermidine putrescine transport system, permease component I
SSUD12_RS05000	COG3842	ATPase activity
SSUD12_RS05005	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SSUD12_RS05010	COG0083	homoserine kinase activity
SSUD12_RS05015	COG0460	homoserine dehydrogenase
SSUD12_RS05020	COG0726	polysaccharide deacetylase
SSUD12_RS05075	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SSUD12_RS05080	COG1132	(ABC) transporter
SSUD12_RS05095	COG0228	four-way junction DNA binding
SSUD12_RS05105	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SSUD12_RS05135	COG0505	Belongs to the CarA family
SSUD12_RS05140	COG0540	Belongs to the ATCase OTCase family
SSUD12_RS05145	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SSUD12_RS05155	COG2824	Alkylphosphonate utilization operon protein PhnA
SSUD12_RS05160	COG0564	pseudouridine synthase activity
SSUD12_RS05180	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SSUD12_RS05185	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SSUD12_RS05195	COG3843	relaxase mobilization nuclease domain protein
SSUD12_RS05250	COG3942	CHAP domain
SSUD12_RS05250	COG1388	LysM domain
SSUD12_RS05340	COG1114	Component of the transport system for branched-chain amino acids
SSUD12_RS05345	COG0301	tRNA thio-modification
SSUD12_RS05350	COG1104	cysteine desulfurase activity
SSUD12_RS05375	COG0539	negative regulation of cytoplasmic translation
SSUD12_RS05395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SSUD12_RS05405	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SSUD12_RS05415	COG0187	DNA topoisomerase II activity
SSUD12_RS05425	COG1074	ATP-dependent DNA helicase activity
SSUD12_RS05430	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SSUD12_RS05460	COG1131	(ABC) transporter
SSUD12_RS05495	COG1011	Hydrolase
SSUD12_RS05505	COG0210	DNA helicase
SSUD12_RS05520	COG1164	Oligoendopeptidase f
SSUD12_RS05530	COG0346	lactoylglutathione lyase activity
SSUD12_RS05535	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SSUD12_RS05540	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SSUD12_RS05545	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SSUD12_RS05555	COG0446	pyridine nucleotide-disulphide oxidoreductase
SSUD12_RS05560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SSUD12_RS05565	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SSUD12_RS05585	COG1882	Formate acetyltransferase
SSUD12_RS05590	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SSUD12_RS05595	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SSUD12_RS05600	COG1447	Phosphotransferase system cellobiose-specific component IIA
SSUD12_RS05610	COG1349	DNA-binding transcription factor activity
SSUD12_RS05615	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SSUD12_RS05650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SSUD12_RS05660	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SSUD12_RS05670	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SSUD12_RS05675	COG4684	Psort location CytoplasmicMembrane, score
SSUD12_RS05680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SSUD12_RS05715	COG0531	amino acid
SSUD12_RS05725	COG0708	Exodeoxyribonuclease III
SSUD12_RS05735	COG1393	Belongs to the ArsC family
SSUD12_RS05740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SSUD12_RS05745	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SSUD12_RS05755	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SSUD12_RS05765	COG4467	Involved in initiation control of chromosome replication
SSUD12_RS05770	COG0470	DNA polymerase III
SSUD12_RS05775	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SSUD12_RS05780	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SSUD12_RS05795	COG0517	IMP dehydrogenase activity
SSUD12_RS05800	COG0658	competence protein
SSUD12_RS05800	COG2333	competence protein COMEC
SSUD12_RS05840	COG1388	LysM domain
SSUD12_RS05840	COG0860	N-Acetylmuramoyl-L-alanine amidase
SSUD12_RS05915	COG0740	serine-type endopeptidase activity
SSUD12_RS05920	COG4695	Portal protein
SSUD12_RS05955	COG0270	DNA (cytosine-5-)-methyltransferase activity
SSUD12_RS05980	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SSUD12_RS06025	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SSUD12_RS06025	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SSUD12_RS06080	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SSUD12_RS06095	COG3684	Belongs to the aldolase LacD family
SSUD12_RS06100	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SSUD12_RS06100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SSUD12_RS06100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SSUD12_RS06105	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SSUD12_RS06105	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SSUD12_RS06105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SSUD12_RS06135	COG0658	competence protein
SSUD12_RS06135	COG2333	competence protein COMEC
SSUD12_RS06140	COG1596	polysaccharide export
SSUD12_RS06140	COG1555	photosystem II stabilization
SSUD12_RS06145	COG0204	Acyl-transferase
SSUD12_RS06150	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SSUD12_RS06155	COG1120	ATPase activity
SSUD12_RS06160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SSUD12_RS06165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SSUD12_RS06170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SSUD12_RS06175	COG0386	Belongs to the glutathione peroxidase family
SSUD12_RS06180	COG1187	pseudouridine synthase activity
SSUD12_RS06185	COG0435	Glutathione S-transferase
SSUD12_RS06205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SSUD12_RS06210	COG1696	Membrane protein involved in D-alanine export
SSUD12_RS06265	COG0363	glucosamine-6-phosphate deaminase activity
SSUD12_RS06270	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SSUD12_RS06275	COG1438	arginine binding
SSUD12_RS06280	COG3064	Membrane
SSUD12_RS06280	COG3583	domain protein
SSUD12_RS06280	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SSUD12_RS06290	COG1288	antiporter activity
SSUD12_RS06295	COG0549	Belongs to the carbamate kinase family
SSUD12_RS06300	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SSUD12_RS06305	COG0454	-acetyltransferase
SSUD12_RS06320	COG1481	regulation of sporulation
SSUD12_RS06325	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SSUD12_RS06330	COG1660	Displays ATPase and GTPase activities
SSUD12_RS06335	COG0251	oxidation-reduction process
SSUD12_RS06345	COG0534	Mate efflux family protein
SSUD12_RS06355	COG0436	Aminotransferase
SSUD12_RS06370	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SSUD12_RS06375	COG0562	UDP-galactopyranose mutase
SSUD12_RS06400	COG2274	protein secretion by the type I secretion system
SSUD12_RS06405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SSUD12_RS06465	COG0613	PHP domain protein
SSUD12_RS06470	COG0542	response to heat
SSUD12_RS06475	COG1396	sequence-specific DNA binding
SSUD12_RS06505	COG2197	response regulator
SSUD12_RS06530	COG1132	(ABC) transporter
SSUD12_RS06555	COG4443	Transcriptional Coactivator p15 (PC4)
SSUD12_RS06560	COG1475	DNA binding
SSUD12_RS06685	COG0270	DNA (cytosine-5-)-methyltransferase activity
SSUD12_RS06705	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SSUD12_RS06730	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SSUD12_RS06740	COG0077	Prephenate dehydratase
SSUD12_RS06745	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SSUD12_RS06760	COG0562	UDP-galactopyranose mutase
SSUD12_RS06775	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SSUD12_RS06790	COG3475	LICD family
SSUD12_RS06800	COG1216	Glycosyl transferase, family 2
SSUD12_RS06815	COG4464	protein tyrosine phosphatase activity
SSUD12_RS06825	COG3944	biosynthesis protein
SSUD12_RS06830	COG1316	TRANSCRIPTIONal
SSUD12_RS06835	COG3022	response to hydroperoxide
SSUD12_RS06840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SSUD12_RS06860	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SSUD12_RS06865	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SSUD12_RS06870	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SSUD12_RS06890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SSUD12_RS06895	COG1126	abc transporter atp-binding protein
SSUD12_RS06900	COG0765	amino acid transport
SSUD12_RS06905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SSUD12_RS06915	COG2755	lipolytic protein G-D-S-L family
SSUD12_RS06915	COG0657	acetylesterase activity
SSUD12_RS06920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SSUD12_RS06930	COG0469	pyruvate kinase activity
SSUD12_RS06935	COG0205	6-phosphofructokinase activity
SSUD12_RS06945	COG2188	Transcriptional regulator
SSUD12_RS06950	COG1131	(ABC) transporter
SSUD12_RS06960	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SSUD12_RS07000	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SSUD12_RS07005	COG1982	Orn Lys Arg decarboxylase major
SSUD12_RS07010	COG2151	metal-sulfur cluster biosynthetic enzyme
SSUD12_RS07015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SSUD12_RS07020	COG0358	DNA primase activity
SSUD12_RS07025	COG1970	mechanosensitive ion channel activity
SSUD12_RS07035	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SSUD12_RS07040	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SSUD12_RS07050	COG0647	UMP catabolic process
SSUD12_RS07055	COG1051	belongs to the nudix hydrolase family
SSUD12_RS07065	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SSUD12_RS07075	COG0058	SHG alpha-glucan phosphorylase activity
SSUD12_RS07080	COG0813	purine-nucleoside phosphorylase activity
SSUD12_RS07085	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SSUD12_RS07095	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
SSUD12_RS07100	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SSUD12_RS07130	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SSUD12_RS07135	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SSUD12_RS07150	COG2268	Band 7 protein
SSUD12_RS07155	COG1704	LemA family
SSUD12_RS07165	COG1573	uracil-dna glycosylase
SSUD12_RS07190	COG2226	methyltransferase
SSUD12_RS07195	COG0488	(ABC) transporter
SSUD12_RS07200	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SSUD12_RS07215	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SSUD12_RS07220	COG3442	glutamine amidotransferase
SSUD12_RS07225	COG2226	methyltransferase
SSUD12_RS07235	COG0488	(ABC) transporter
SSUD12_RS07275	COG3842	ATPase activity
SSUD12_RS07295	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SSUD12_RS07300	COG3527	Alpha-acetolactate decarboxylase
SSUD12_RS07310	COG0628	permease
SSUD12_RS07315	COG2706	6-phosphogluconolactonase activity
SSUD12_RS07325	COG1011	Hydrolase
SSUD12_RS07350	COG0560	Phosphoserine phosphatase
SSUD12_RS07355	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
SSUD12_RS07360	COG0187	DNA topoisomerase II activity
SSUD12_RS07365	COG0693	protein deglycase activity
SSUD12_RS07370	COG0772	Belongs to the SEDS family
SSUD12_RS07395	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SSUD12_RS07400	COG0716	FMN binding
SSUD12_RS07410	COG1605	Chorismate mutase
SSUD12_RS07410	COG0287	Prephenate dehydrogenase
SSUD12_RS07415	COG0038	chloride channel
SSUD12_RS07425	COG0737	Belongs to the 5'-nucleotidase family
SSUD12_RS07430	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SSUD12_RS07435	COG1466	dna polymerase III delta subunit
SSUD12_RS07465	COG0559	Belongs to the binding-protein-dependent transport system permease family
SSUD12_RS07470	COG0683	leucine binding
SSUD12_RS07485	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SSUD12_RS07490	COG0366	Alpha amylase catalytic
SSUD12_RS07500	COG0395	ABC-type sugar transport system, permease component
SSUD12_RS07505	COG1175	transmembrane transport
SSUD12_RS07510	COG1653	transport
SSUD12_RS07520	COG2207	Transcriptional regulator
SSUD12_RS07525	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SSUD12_RS07530	COG0626	cystathionine gamma-synthase activity
SSUD12_RS07550	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SSUD12_RS07555	COG2827	Endonuclease containing a URI domain
SSUD12_RS07585	COG0640	Transcriptional regulator
SSUD12_RS07590	COG0513	Belongs to the DEAD box helicase family
SSUD12_RS07595	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SSUD12_RS07635	COG0494	nUDIX hydrolase
SSUD12_RS07640	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SSUD12_RS07650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SSUD12_RS07655	COG1028	Short-chain dehydrogenase reductase Sdr
SSUD12_RS07675	COG1695	Transcriptional regulator
SSUD12_RS07685	COG0577	efflux transmembrane transporter activity
SSUD12_RS07690	COG1136	(ABC) transporter
SSUD12_RS07695	COG2205	protein histidine kinase activity
SSUD12_RS07710	COG0436	Aminotransferase
SSUD12_RS07720	COG1174	glycine betaine transport
SSUD12_RS07725	COG0517	IMP dehydrogenase activity
SSUD12_RS07725	COG1125	glycine betaine transport
SSUD12_RS07745	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SSUD12_RS07750	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SSUD12_RS07755	COG1482	cell wall glycoprotein biosynthetic process
SSUD12_RS07785	COG3091	SprT-like family
SSUD12_RS07790	COG2183	response to ionizing radiation
SSUD12_RS07795	COG0656	L-ascorbic acid biosynthetic process
SSUD12_RS07805	COG4708	membrane
SSUD12_RS07810	COG2246	polysaccharide biosynthetic process
SSUD12_RS07820	COG0024	Methionine aminopeptidase
SSUD12_RS07830	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SSUD12_RS07835	COG2249	NAD(P)H dehydrogenase (quinone) activity
SSUD12_RS07840	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SSUD12_RS07845	COG2131	deaminase
SSUD12_RS07855	COG1363	Peptidase, m42
SSUD12_RS07870	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SSUD12_RS07875	COG1956	GAF domain-containing protein
SSUD12_RS07885	COG1695	Transcriptional regulator
SSUD12_RS07895	COG0673	inositol 2-dehydrogenase activity
SSUD12_RS07900	COG0513	Belongs to the DEAD box helicase family
SSUD12_RS07905	COG0726	polysaccharide deacetylase
SSUD12_RS07920	COG0183	Belongs to the thiolase family
SSUD12_RS07925	COG3425	synthase
SSUD12_RS07960	COG3422	double-strand break repair
SSUD12_RS07995	COG0776	regulation of translation
SSUD12_RS08005	COG2755	lipolytic protein G-D-S-L family
SSUD12_RS08010	COG1307	EDD domain protein, DegV family
SSUD12_RS08015	COG0497	DNA recombination
SSUD12_RS08020	COG1438	arginine binding
SSUD12_RS08025	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SSUD12_RS08035	COG1722	exodeoxyribonuclease VII activity
SSUD12_RS08040	COG1570	exodeoxyribonuclease VII activity
SSUD12_RS08045	COG2321	neutral zinc metallopeptidase
SSUD12_RS08050	COG1755	Isoprenylcysteine carboxyl methyltransferase
SSUD12_RS08055	COG2801	Transposase and inactivated derivatives
SSUD12_RS08065	COG5002	protein histidine kinase activity
SSUD12_RS08070	COG0745	RESPONSE REGULATOR receiver
SSUD12_RS08095	COG1227	inorganic diphosphatase activity
SSUD12_RS08105	COG1733	regulation of RNA biosynthetic process
SSUD12_RS08130	COG2514	catechol 2,3-dioxygenase activity
SSUD12_RS08140	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SSUD12_RS08145	COG1253	flavin adenine dinucleotide binding
SSUD12_RS08150	COG1119	ATPase activity
SSUD12_RS08155	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SSUD12_RS08175	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SSUD12_RS08180	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SSUD12_RS08185	COG0133	tryptophan synthase activity
SSUD12_RS08210	COG4470	Protein conserved in bacteria
SSUD12_RS08215	COG3480	Lon protease (S16) C-terminal proteolytic domain
SSUD12_RS08220	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SSUD12_RS08225	COG0742	ribosomal rna small subunit methyltransferase
SSUD12_RS08235	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SSUD12_RS08240	COG4483	Protein conserved in bacteria
SSUD12_RS08245	COG2197	response regulator
SSUD12_RS08250	COG4585	Histidine kinase
SSUD12_RS08250	COG2203	Gaf domain
SSUD12_RS08260	COG1131	(ABC) transporter
SSUD12_RS08275	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SSUD12_RS08285	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SSUD12_RS08285	COG2755	lipolytic protein G-D-S-L family
SSUD12_RS08290	COG0671	phosphoesterase, PA-phosphatase related
SSUD12_RS08295	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SSUD12_RS08310	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SSUD12_RS08315	COG1187	pseudouridine synthase activity
SSUD12_RS08320	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SSUD12_RS08325	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SSUD12_RS08330	COG0582	viral genome integration into host DNA
SSUD12_RS08350	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SSUD12_RS08355	COG3763	UPF0154 protein
SSUD12_RS08365	COG3579	cysteine-type endopeptidase activity
SSUD12_RS08380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SSUD12_RS08385	COG1254	Belongs to the acylphosphatase family
SSUD12_RS08395	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SSUD12_RS08400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SSUD12_RS08410	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SSUD12_RS08420	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SSUD12_RS08435	COG1160	GTP binding
SSUD12_RS08445	COG1484	DNA-dependent DNA replication
SSUD12_RS08455	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SSUD12_RS08460	COG0628	permease
SSUD12_RS08465	COG0745	RESPONSE REGULATOR receiver
SSUD12_RS08470	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SSUD12_RS08480	COG0492	ferredoxin-NADP+ reductase activity
SSUD12_RS08490	COG0513	Belongs to the DEAD box helicase family
SSUD12_RS08505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SSUD12_RS08510	COG0768	penicillin binding
SSUD12_RS08520	COG0275	rRNA processing
SSUD12_RS08565	COG4939	FMN-binding domain protein
SSUD12_RS08570	COG0142	geranyltranstransferase activity
SSUD12_RS08575	COG1252	NADH dehydrogenase
SSUD12_RS08590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SSUD12_RS08595	COG0569	domain protein
SSUD12_RS08600	COG0534	Mate efflux family protein
SSUD12_RS08610	COG4224	UPF0291 protein
SSUD12_RS08620	COG0751	glycine-tRNA ligase activity
SSUD12_RS08645	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SSUD12_RS08650	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SSUD12_RS08655	COG1464	Belongs to the NlpA lipoprotein family
SSUD12_RS08660	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SSUD12_RS08675	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SSUD12_RS08680	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SSUD12_RS08685	COG2252	PERMEase
SSUD12_RS08690	COG0561	phosphatase activity
SSUD12_RS08700	COG3715	PTS system
SSUD12_RS08705	COG3716	PTS system mannose fructose sorbose family IID component
SSUD12_RS08725	COG1266	CAAX protease self-immunity
SSUD12_RS08745	COG0439	Biotin carboxylase
SSUD12_RS08765	COG1028	Short-chain dehydrogenase reductase Sdr
SSUD12_RS08770	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SSUD12_RS08775	COG2070	2-Nitropropane dioxygenase
SSUD12_RS08785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SSUD12_RS08795	COG1024	Enoyl-CoA hydratase
SSUD12_RS08800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SSUD12_RS08805	COG0527	aspartate kinase activity
SSUD12_RS08815	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SSUD12_RS08820	COG0736	holo-[acyl-carrier-protein] synthase activity
SSUD12_RS08825	COG0653	protein targeting
SSUD12_RS08835	COG1940	carbohydrate kinase activity
SSUD12_RS08840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SSUD12_RS08840	COG2190	(PTS) system
SSUD12_RS08840	COG1263	PTS System
SSUD12_RS08845	COG1621	beta-fructofuranosidase activity
SSUD12_RS08850	COG1609	Transcriptional regulator
SSUD12_RS08855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SSUD12_RS08870	COG0006	proline dipeptidase activity
SSUD12_RS08895	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SSUD12_RS08915	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SSUD12_RS08920	COG0629	single-stranded DNA binding
SSUD12_RS08930	COG0095	Lipoate-protein ligase
SSUD12_RS08935	COG2723	6-phospho-beta-galactosidase activity
SSUD12_RS08950	COG2723	6-phospho-beta-galactosidase activity
SSUD12_RS08955	COG2723	6-phospho-beta-galactosidase activity
SSUD12_RS08960	COG2207	Transcriptional regulator
SSUD12_RS08960	COG1917	Cupin 2, conserved barrel domain protein
SSUD12_RS08970	COG1263	PTS System
SSUD12_RS08970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SSUD12_RS08970	COG2190	(PTS) system
SSUD12_RS08975	COG3711	transcriptional antiterminator
SSUD12_RS08990	COG0508	dehydrogenase complex catalyzes the overall conversion of
SSUD12_RS08995	COG0508	dehydrogenase complex catalyzes the overall conversion of
SSUD12_RS08995	COG0022	dehydrogenase e1 component
SSUD12_RS09000	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SSUD12_RS09005	COG2860	membrane
SSUD12_RS09020	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SSUD12_RS09025	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SSUD12_RS09035	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SSUD12_RS09040	COG0195	Participates in both transcription termination and antitermination
SSUD12_RS09050	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SSUD12_RS09060	COG4473	ABC transporter
SSUD12_RS09065	COG1131	(ABC) transporter
SSUD12_RS09070	COG0537	adenosine 5'-monophosphoramidase activity
SSUD12_RS09080	COG1316	TRANSCRIPTIONal
SSUD12_RS09090	COG0802	atpase or kinase
SSUD12_RS09095	COG1461	Dihydroxyacetone kinase
SSUD12_RS09105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SSUD12_RS09110	COG0601	transmembrane transport
SSUD12_RS09115	COG4608	Belongs to the ABC transporter superfamily
SSUD12_RS09130	COG1686	Belongs to the peptidase S11 family
SSUD12_RS09145	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SSUD12_RS09150	COG0719	Fe-S assembly protein
SSUD12_RS09160	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SSUD12_RS09165	COG4862	establishment of competence for transformation
SSUD12_RS09170	COG1968	undecaprenyl-diphosphatase activity
SSUD12_RS09175	COG0765	amino acid transport
SSUD12_RS09195	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SSUD12_RS09200	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SSUD12_RS09205	COG0440	acetolactate synthase activity
SSUD12_RS09210	COG0028	Belongs to the TPP enzyme family
SSUD12_RS09215	COG0463	Glycosyl transferase, family 2
SSUD12_RS09230	COG0129	dihydroxy-acid dehydratase activity
SSUD12_RS09235	COG1442	glycosyl transferase family 8
SSUD12_RS09245	COG2151	metal-sulfur cluster biosynthetic enzyme
SSUD12_RS09265	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SSUD12_RS09280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SSUD12_RS09305	COG3842	ATPase activity
SSUD12_RS09315	COG2207	Transcriptional regulator
SSUD12_RS09315	COG4753	response regulator
SSUD12_RS09320	COG2972	Histidine kinase
SSUD12_RS09330	COG1653	transport
SSUD12_RS09335	COG0395	ABC-type sugar transport system, permease component
SSUD12_RS09340	COG1175	transmembrane transport
SSUD12_RS09355	COG0383	alpha-mannosidase activity
SSUD12_RS09375	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SSUD12_RS09395	COG1045	serine acetyltransferase
SSUD12_RS09400	COG1185	polyribonucleotide nucleotidyltransferase activity
SSUD12_RS09405	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SSUD12_RS09440	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SSUD12_RS09445	COG1187	pseudouridine synthase activity
SSUD12_RS09460	COG0242	peptide deformylase activity
SSUD12_RS09470	COG0066	3-isopropylmalate dehydratase activity
SSUD12_RS09475	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SSUD12_RS09500	COG2309	aminopeptidase activity
SSUD12_RS09510	COG2176	DNA-directed DNA polymerase activity
SSUD12_RS09515	COG2376	Dihydroxyacetone kinase
SSUD12_RS09525	COG2376	Dihydroxyacetone kinase
SSUD12_RS09530	COG1461	Dihydroxyacetone kinase
SSUD12_RS09535	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SSUD12_RS09540	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SSUD12_RS09545	COG0442	prolyl-tRNA aminoacylation
SSUD12_RS09555	COG4589	Belongs to the CDS family
SSUD12_RS09560	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SSUD12_RS09565	COG1862	Preprotein translocase
SSUD12_RS09575	COG1181	Belongs to the D-alanine--D-alanine ligase family
SSUD12_RS09575	COG2918	glutathione biosynthetic process
SSUD12_RS09585	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SSUD12_RS09590	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SSUD12_RS09595	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SSUD12_RS09600	COG0542	response to heat
SSUD12_RS09605	COG4463	regulation of RNA biosynthetic process
SSUD12_RS09620	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SSUD12_RS09655	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SSUD12_RS09660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SSUD12_RS09665	COG0492	ferredoxin-NADP+ reductase activity
SSUD12_RS09670	COG0564	pseudouridine synthase activity
SSUD12_RS09715	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SSUD12_RS09735	COG1564	THIamine pyrophosphokinase
SSUD12_RS09745	COG1162	GTPase activity
SSUD12_RS09755	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SSUD12_RS09760	COG1132	(ABC) transporter
SSUD12_RS09815	COG0084	hydrolase, TatD family'
SSUD12_RS09825	COG1847	R3H domain protein
SSUD12_RS09835	COG0594	ribonuclease P activity
SSUD12_RS09840	COG0165	Argininosuccinate lyase
SSUD12_RS09845	COG0137	argininosuccinate synthase activity
SSUD12_RS09855	COG1827	regulation of RNA biosynthetic process
SSUD12_RS09870	COG2040	homocysteine
SSUD12_RS09875	COG0833	amino acid
SSUD12_RS09920	COG0756	dUTP diphosphatase activity
SSUD12_RS09945	COG0577	efflux transmembrane transporter activity
SSUD12_RS09945	COG1136	(ABC) transporter
SSUD12_RS09950	COG1132	(ABC) transporter
SSUD12_RS09955	COG1132	(ABC) transporter
SSUD12_RS09965	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SSUD12_RS09970	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SSUD12_RS09975	COG0705	Rhomboid family
SSUD12_RS09980	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SSUD12_RS09985	COG1473	amidohydrolase
SSUD12_RS09990	COG2171	N-acyltransferase activity
SSUD12_RS10000	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SSUD12_RS10005	COG0166	Belongs to the GPI family
SSUD12_RS10020	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SSUD12_RS10045	COG3623	hexulose-6-phosphate isomerase
SSUD12_RS10070	COG1523	belongs to the glycosyl hydrolase 13 family
SSUD12_RS10085	COG0463	Glycosyl transferase, family 2
SSUD12_RS10105	COG1609	Transcriptional regulator
SSUD12_RS10110	COG1126	abc transporter atp-binding protein
SSUD12_RS10115	COG0765	amino acid transport
SSUD12_RS10120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SSUD12_RS10125	COG3942	CHAP domain
SSUD12_RS10130	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SSUD12_RS10140	COG1447	Phosphotransferase system cellobiose-specific component IIA
SSUD12_RS10150	COG3711	transcriptional antiterminator
SSUD12_RS10150	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SSUD12_RS10160	COG2723	6-phospho-beta-galactosidase activity
SSUD12_RS10165	COG1486	melibiose metabolic process
SSUD12_RS10175	COG4667	esterase of the alpha-beta hydrolase superfamily
SSUD12_RS10180	COG3590	peptidase
SSUD12_RS10185	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SSUD12_RS10190	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SSUD12_RS10190	COG1321	iron dependent repressor
SSUD12_RS10195	COG1121	(ABC) transporter
SSUD12_RS10205	COG0803	Belongs to the bacterial solute-binding protein 9 family
SSUD12_RS10230	COG1490	D-aminoacyl-tRNA deacylase activity
SSUD12_RS10240	COG0737	Belongs to the 5'-nucleotidase family
SSUD12_RS10255	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SSUD12_RS10280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SSUD12_RS10305	COG0737	Belongs to the 5'-nucleotidase family
SSUD12_RS10315	COG1328	CTP reductase activity
SSUD12_RS10320	COG1126	abc transporter atp-binding protein
SSUD12_RS10330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SSUD12_RS10335	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SSUD12_RS10350	COG1438	arginine binding
SSUD12_RS10355	COG0018	arginyl-trna synthetase
SSUD12_RS10375	COG1640	4-alpha-glucanotransferase
SSUD12_RS10380	COG2182	Extracellular solute-binding protein
SSUD12_RS10385	COG1175	transmembrane transport
SSUD12_RS10390	COG3833	ABC-type maltose transport systems, permease component
SSUD12_RS10395	COG5521	maltodextrose utilization protein MalA
SSUD12_RS10400	COG1609	Transcriptional regulator
SSUD12_RS10405	COG1523	belongs to the glycosyl hydrolase 13 family
SSUD12_RS10410	COG1780	Probably involved in ribonucleotide reductase function
SSUD12_RS10415	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SSUD12_RS10420	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SSUD12_RS10425	COG2153	protein acetylation
SSUD12_RS10430	COG4989	oxidoreductase activity
SSUD12_RS10435	COG1216	Glycosyl transferase, family 2
SSUD12_RS10455	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SSUD12_RS10470	COG0305	Participates in initiation and elongation during chromosome replication
SSUD12_RS10475	COG0359	binds to the 23S rRNA
SSUD12_RS10485	COG0445	tRNA wobble uridine modification
SSUD12_RS10500	COG1051	belongs to the nudix hydrolase family
SSUD12_RS10505	COG1733	regulation of RNA biosynthetic process
SSUD12_RS10515	COG0482	sulfurtransferase activity
SSUD12_RS10520	COG1760	l-serine dehydratase
SSUD12_RS10525	COG1760	l-serine dehydratase
SSUD12_RS10535	COG0745	RESPONSE REGULATOR receiver
SSUD12_RS10540	COG3850	Histidine kinase
SSUD12_RS10540	COG5002	protein histidine kinase activity
SSUD12_RS10550	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SSUD12_RS10555	COG1122	ATPase activity
SSUD12_RS10560	COG1122	ATPase activity
SSUD12_RS10565	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SSUD12_RS10570	COG1426	Protein conserved in bacteria
SSUD12_RS10575	COG0612	Peptidase, M16
SSUD12_RS10580	COG0612	Peptidase, M16
SSUD12_RS10650	COG0582	viral genome integration into host DNA
SSUD12_RS10660	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SSUD12_RS10665	COG0517	IMP dehydrogenase activity
SSUD12_RS10665	COG0516	GMP reductase activity
SSUD12_RS10675	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SSUD12_RS10680	COG0488	(ABC) transporter
SSUD12_RS10715	COG1674	ftsk spoiiie
SSUD12_RS10755	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SSUD12_RS10760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SSUD12_RS10765	COG1475	DNA binding
SSUD12_RS10805	COG0488	(ABC) transporter
SSUD12_RS10810	COG0488	(ABC) transporter
SSUD12_RS10835	COG3843	relaxase mobilization nuclease domain protein