locus-tag	class	description
A6M16_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A6M16_RS00010	COG0592	DNA-directed DNA polymerase activity
A6M16_RS00030	COG0012	GTP binding
A6M16_RS00035	COG0193	aminoacyl-tRNA hydrolase activity
A6M16_RS00040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6M16_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A6M16_RS00065	COG0037	tRNA processing
A6M16_RS00075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6M16_RS00190	COG1792	Involved in formation and maintenance of cell shape
A6M16_RS00205	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A6M16_RS00210	COG0436	Aminotransferase
A6M16_RS00215	COG1381	Involved in DNA repair and RecF pathway recombination
A6M16_RS00220	COG0416	fatty acid biosynthetic process
A6M16_RS00225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6M16_RS00250	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6M16_RS00255	COG0138	bifunctional purine biosynthesis protein purh
A6M16_RS00270	COG0151	Belongs to the GarS family
A6M16_RS00275	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A6M16_RS00295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6M16_RS00315	COG1131	(ABC) transporter
A6M16_RS00325	COG1132	(ABC) transporter
A6M16_RS00330	COG2255	four-way junction helicase activity
A6M16_RS00340	COG0546	phosphoglycolate phosphatase activity
A6M16_RS00350	COG0285	dihydrofolate synthase activity
A6M16_RS00365	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A6M16_RS00370	COG0632	four-way junction helicase activity
A6M16_RS00375	COG0519	Catalyzes the synthesis of GMP from XMP
A6M16_RS00390	COG1393	Belongs to the ArsC family
A6M16_RS00395	COG4472	Bacterial protein of unknown function (DUF965)
A6M16_RS00400	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A6M16_RS00405	COG3906	Belongs to the UPF0473 family
A6M16_RS00410	COG0051	transcription antitermination factor activity, RNA binding
A6M16_RS00415	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A6M16_RS00420	COG0088	Forms part of the polypeptide exit tunnel
A6M16_RS00425	COG0089	rRNA binding
A6M16_RS00430	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A6M16_RS00435	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6M16_RS00440	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A6M16_RS00445	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A6M16_RS00450	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A6M16_RS00455	COG0255	Belongs to the universal ribosomal protein uL29 family
A6M16_RS00460	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A6M16_RS00465	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A6M16_RS00470	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A6M16_RS00475	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A6M16_RS00480	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A6M16_RS00485	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A6M16_RS00495	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A6M16_RS00500	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A6M16_RS00505	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A6M16_RS00510	COG1841	ribosomal large subunit assembly
A6M16_RS00520	COG0201	protein transport
A6M16_RS00525	COG0563	adenylate kinase activity
A6M16_RS00530	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6M16_RS00535	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6M16_RS00540	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A6M16_RS00550	COG0202	RNA polymerase activity
A6M16_RS00690	COG2801	Transposase and inactivated derivatives
A6M16_RS00715	COG1121	(ABC) transporter
A6M16_RS00720	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6M16_RS00725	COG3443	Belongs to the bacterial solute-binding protein 9 family
A6M16_RS00725	COG0803	Belongs to the bacterial solute-binding protein 9 family
A6M16_RS00750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6M16_RS00755	COG0085	RNA polymerase activity
A6M16_RS00760	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A6M16_RS00770	COG1619	proteins homologs of microcin C7 resistance protein MccF
A6M16_RS00775	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6M16_RS00780	COG1459	type II secretion system
A6M16_RS00785	COG4537	Required for transformation and DNA binding
A6M16_RS00815	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A6M16_RS00825	COG0285	dihydrofolate synthase activity
A6M16_RS00830	COG1363	Peptidase, m42
A6M16_RS00840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6M16_RS00850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6M16_RS00875	COG0459	protein refolding
A6M16_RS00885	COG0049	tRNA binding
A6M16_RS00890	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6M16_RS00895	COG3590	peptidase
A6M16_RS00905	COG0126	phosphoglycerate kinase activity
A6M16_RS00915	COG0789	Transcriptional regulator
A6M16_RS00920	COG0174	glutamine synthetase
A6M16_RS00935	COG1214	PFAM Peptidase M22, glycoprotease
A6M16_RS00945	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A6M16_RS00950	COG2207	Transcriptional regulator
A6M16_RS00960	COG1175	transmembrane transport
A6M16_RS00965	COG0395	ABC-type sugar transport system, permease component
A6M16_RS00985	COG2855	membrane
A6M16_RS00995	COG1131	(ABC) transporter
A6M16_RS01005	COG2081	HI0933 family
A6M16_RS01010	COG2723	6-phospho-beta-galactosidase activity
A6M16_RS01020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6M16_RS01035	COG3959	Transketolase, thiamine diphosphate binding domain
A6M16_RS01040	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A6M16_RS01045	COG0584	glycerophosphoryl diester phosphodiesterase
A6M16_RS01050	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A6M16_RS01055	COG2222	sugar isomerase
A6M16_RS01085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A6M16_RS01095	COG3942	CHAP domain
A6M16_RS01100	COG1882	Formate acetyltransferase
A6M16_RS01115	COG2910	NAD(P)H-binding
A6M16_RS01130	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6M16_RS01135	COG0681	Belongs to the peptidase S26 family
A6M16_RS01155	COG0366	Alpha amylase catalytic
A6M16_RS01165	COG1263	PTS System
A6M16_RS01165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6M16_RS01170	COG2188	Transcriptional regulator
A6M16_RS01185	COG1193	negative regulation of DNA recombination
A6M16_RS01220	COG3118	belongs to the thioredoxin family
A6M16_RS01225	COG0318	PFAM AMP-dependent synthetase and ligase
A6M16_RS01230	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6M16_RS01230	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6M16_RS01255	COG1115	amino acid carrier protein
A6M16_RS01260	COG0668	transmembrane transport
A6M16_RS01275	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A6M16_RS01285	COG0167	dihydroorotate dehydrogenase activity
A6M16_RS01290	COG2843	Capsule synthesis protein
A6M16_RS01295	COG0561	phosphatase activity
A6M16_RS01310	COG1131	(ABC) transporter
A6M16_RS01315	COG1309	transcriptional regulator
A6M16_RS01320	COG1511	domain protein
A6M16_RS01365	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6M16_RS01370	COG0433	COG0433 Predicted ATPase
A6M16_RS01375	COG0494	nUDIX hydrolase
A6M16_RS01440	COG0701	Predicted permease
A6M16_RS01450	COG1393	Belongs to the ArsC family
A6M16_RS01470	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6M16_RS01475	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A6M16_RS01480	COG0124	histidyl-tRNA synthetase
A6M16_RS01485	COG1064	alcohol dehydrogenase
A6M16_RS01490	COG1454	alcohol dehydrogenase
A6M16_RS01490	COG1012	belongs to the aldehyde dehydrogenase family
A6M16_RS01500	COG4988	ABC transporter
A6M16_RS01505	COG1132	(ABC) transporter
A6M16_RS01520	COG1129	ABC transporter
A6M16_RS01525	COG0534	Mate efflux family protein
A6M16_RS01530	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A6M16_RS01545	COG1304	FMN binding
A6M16_RS01550	COG1132	(ABC) transporter
A6M16_RS01555	COG1132	(ABC) transporter
A6M16_RS01560	COG3830	Belongs to the UPF0237 family
A6M16_RS01565	COG2848	UPF0210 protein
A6M16_RS01570	COG0588	phosphoglycerate mutase activity
A6M16_RS01575	COG1420	regulation of RNA biosynthetic process
A6M16_RS01580	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A6M16_RS01585	COG0443	Heat shock 70 kDa protein
A6M16_RS01590	COG0484	heat shock protein binding
A6M16_RS01595	COG0095	Lipoate-protein ligase
A6M16_RS01605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6M16_RS01635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6M16_RS01640	COG0765	amino acid transport
A6M16_RS01645	COG3655	Transcriptional regulator
A6M16_RS01655	COG2217	Heavy metal translocating P-type atpase
A6M16_RS01670	COG0351	phosphomethylpyrimidine kinase
A6M16_RS01680	COG4475	Protein of unknown function (DUF436)
A6M16_RS01710	COG1902	pentaerythritol trinitrate reductase activity
A6M16_RS01710	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6M16_RS01730	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6M16_RS01755	COG2801	Transposase and inactivated derivatives
A6M16_RS01760	COG3343	RNA polymerase activity
A6M16_RS01765	COG0504	CTP synthase activity
A6M16_RS01780	COG0191	fructose-bisphosphate aldolase activity
A6M16_RS01785	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A6M16_RS01825	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6M16_RS01830	COG2801	Transposase and inactivated derivatives
A6M16_RS01865	COG0436	Aminotransferase
A6M16_RS01870	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A6M16_RS01875	COG1335	isochorismatase
A6M16_RS01880	COG0335	large ribosomal subunit rRNA binding
A6M16_RS01895	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6M16_RS01900	COG0154	amidase activity
A6M16_RS01905	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6M16_RS01910	COG1609	Transcriptional regulator
A6M16_RS01915	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A6M16_RS01920	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
A6M16_RS01930	COG3142	Participates in the control of copper homeostasis
A6M16_RS01945	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A6M16_RS01950	COG1534	Rna-binding protein
A6M16_RS01955	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A6M16_RS01960	COG1713	HD superfamily hydrolase involved in NAD metabolism
A6M16_RS01970	COG1335	isochorismatase
A6M16_RS01975	COG0799	negative regulation of ribosome biogenesis
A6M16_RS01980	COG2226	methyltransferase
A6M16_RS02000	COG0242	peptide deformylase activity
A6M16_RS02010	COG1640	4-alpha-glucanotransferase
A6M16_RS02015	COG0058	SHG alpha-glucan phosphorylase activity
A6M16_RS02030	COG2190	(PTS) system
A6M16_RS02030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6M16_RS02030	COG1263	PTS System
A6M16_RS02035	COG0217	transcriptional regulatory protein
A6M16_RS02045	COG4720	Psort location CytoplasmicMembrane, score
A6M16_RS02055	COG1054	Belongs to the UPF0176 family
A6M16_RS02065	COG1122	ATPase activity
A6M16_RS02080	COG0357	Ribosomal RNA small subunit methyltransferase G
A6M16_RS02085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6M16_RS02090	COG3331	DNA recombination
A6M16_RS02095	COG4474	Belongs to the UPF0398 family
A6M16_RS02100	COG3599	regulation of cell shape
A6M16_RS02110	COG0116	Belongs to the methyltransferase superfamily
A6M16_RS02120	COG1854	S-ribosylhomocysteine lyase activity
A6M16_RS02125	COG1418	mRNA catabolic process
A6M16_RS02135	COG1758	RNA polymerase activity
A6M16_RS02140	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A6M16_RS02145	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A6M16_RS02150	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6M16_RS02150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6M16_RS02155	COG0631	protein serine/threonine phosphatase activity
A6M16_RS02160	COG0515	serine threonine protein kinase
A6M16_RS02160	COG2815	serine threonine protein kinase
A6M16_RS02185	COG1098	S1 RNA binding domain
A6M16_RS02195	COG1739	Uncharacterized protein family UPF0029
A6M16_RS02200	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A6M16_RS02290	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6M16_RS02295	COG2137	regulation of response to DNA damage stimulus
A6M16_RS02300	COG3557	Belongs to the UPF0374 family
A6M16_RS02310	COG2188	Transcriptional regulator
A6M16_RS02315	COG2188	Transcriptional regulator
A6M16_RS02325	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6M16_RS02335	COG3716	PTS system mannose fructose sorbose family IID component
A6M16_RS02345	COG2017	converts alpha-aldose to the beta-anomer
A6M16_RS02360	COG0346	lactoylglutathione lyase activity
A6M16_RS02390	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A6M16_RS02420	COG1217	gtp-binding protein TYPA
A6M16_RS02435	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A6M16_RS02450	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A6M16_RS02455	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6M16_RS02460	COG1799	cell septum assembly
A6M16_RS02475	COG3599	regulation of cell shape
A6M16_RS02495	COG0494	nUDIX hydrolase
A6M16_RS02495	COG0406	alpha-ribazole phosphatase activity
A6M16_RS02510	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A6M16_RS02545	COG0789	Transcriptional regulator
A6M16_RS02560	COG0826	peptidase U32
A6M16_RS02570	COG4443	Transcriptional Coactivator p15 (PC4)
A6M16_RS02575	COG1268	BioY protein
A6M16_RS02580	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A6M16_RS02585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6M16_RS02590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6M16_RS02595	COG1136	(ABC) transporter
A6M16_RS02600	COG0577	efflux transmembrane transporter activity
A6M16_RS02625	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A6M16_RS02635	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A6M16_RS02645	COG3859	Proton-coupled thiamine transporter YuaJ
A6M16_RS02665	COG0772	Belongs to the SEDS family
A6M16_RS02670	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A6M16_RS02685	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6M16_RS02690	COG0149	triose-phosphate isomerase activity
A6M16_RS02700	COG1078	dGTPase activity
A6M16_RS02735	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A6M16_RS02740	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A6M16_RS02745	COG2884	Cell division ATP-binding protein ftsE
A6M16_RS02750	COG2177	Part of the ABC transporter FtsEX involved in
A6M16_RS02770	COG1132	(ABC) transporter
A6M16_RS02775	COG1132	(ABC) transporter
A6M16_RS02780	COG1011	Hydrolase
A6M16_RS02800	COG1737	Transcriptional regulator
A6M16_RS02810	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A6M16_RS02815	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A6M16_RS02820	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A6M16_RS02830	COG2814	Major facilitator Superfamily
A6M16_RS02835	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6M16_RS02845	COG0557	exoribonuclease II activity
A6M16_RS02850	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A6M16_RS02865	COG1063	alcohol dehydrogenase
A6M16_RS02880	COG2217	Heavy metal translocating P-type atpase
A6M16_RS02885	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A6M16_RS02895	COG1136	(ABC) transporter
A6M16_RS02910	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6M16_RS02910	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6M16_RS02920	COG1832	CoA-binding protein
A6M16_RS02930	COG0343	queuine tRNA-ribosyltransferase activity
A6M16_RS02945	COG1609	Transcriptional regulator
A6M16_RS02955	COG0438	transferase activity, transferring glycosyl groups
A6M16_RS02970	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A6M16_RS02975	COG0765	amino acid transport
A6M16_RS02980	COG0765	amino acid transport
A6M16_RS02985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6M16_RS02995	COG0745	RESPONSE REGULATOR receiver
A6M16_RS03005	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A6M16_RS03010	COG0488	(ABC) transporter
A6M16_RS03015	COG0768	penicillin binding
A6M16_RS03020	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A6M16_RS03025	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6M16_RS03045	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6M16_RS03055	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A6M16_RS03065	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6M16_RS03085	COG1609	Transcriptional regulator
A6M16_RS03090	COG4209	transmembrane transport
A6M16_RS03095	COG0395	ABC-type sugar transport system, permease component
A6M16_RS03105	COG1621	beta-fructofuranosidase activity
A6M16_RS03110	COG0697	spore germination
A6M16_RS03110	COG1674	ftsk spoiiie
A6M16_RS03115	COG0346	lactoylglutathione lyase activity
A6M16_RS03140	COG0625	glutathione transferase activity
A6M16_RS03145	COG2244	polysaccharide biosynthetic process
A6M16_RS03150	COG0528	UMP kinase activity
A6M16_RS03155	COG0233	cytoplasmic translational termination
A6M16_RS03160	COG2996	Protein conserved in bacteria
A6M16_RS03175	COG4479	Belongs to the UPF0346 family
A6M16_RS03180	COG1702	phosphate starvation-inducible protein PhoH
A6M16_RS03185	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A6M16_RS03190	COG2807	transmembrane transport
A6M16_RS03200	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6M16_RS03205	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6M16_RS03215	COG1234	tRNA 3'-trailer cleavage
A6M16_RS03220	COG0300	oxidoreductase activity
A6M16_RS03230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6M16_RS03235	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A6M16_RS03235	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A6M16_RS03245	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6M16_RS03260	COG2384	SAM-dependent methyltransferase
A6M16_RS03265	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A6M16_RS03275	COG0640	Transcriptional regulator
A6M16_RS03285	COG2801	Transposase and inactivated derivatives
A6M16_RS03295	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A6M16_RS03305	COG0135	phosphoribosylanthranilate isomerase activity
A6M16_RS03310	COG1088	dTDP-glucose 4,6-dehydratase activity
A6M16_RS03315	COG1091	dTDP-4-dehydrorhamnose reductase activity
A6M16_RS03345	COG1215	transferase activity, transferring glycosyl groups
A6M16_RS03375	COG1442	glycosyl transferase family 8
A6M16_RS03380	COG1442	glycosyl transferase family 8
A6M16_RS03380	COG1216	Glycosyl transferase, family 2
A6M16_RS03395	COG1216	Glycosyl transferase, family 2
A6M16_RS03425	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A6M16_RS03435	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A6M16_RS03450	COG1368	sulfuric ester hydrolase activity
A6M16_RS03455	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6M16_RS03460	COG0710	3-dehydroquinate dehydratase activity
A6M16_RS03465	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A6M16_RS03470	COG0287	Prephenate dehydrogenase
A6M16_RS03475	COG3679	Belongs to the UPF0342 family
A6M16_RS03485	COG3684	Belongs to the aldolase LacD family
A6M16_RS03505	COG4120	Belongs to the binding-protein-dependent transport system permease family
A6M16_RS03510	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A6M16_RS03510	COG1116	anion transmembrane transporter activity
A6M16_RS03515	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A6M16_RS03520	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A6M16_RS03525	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6M16_RS03530	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6M16_RS03540	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6M16_RS03540	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6M16_RS03550	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
A6M16_RS03555	COG3620	sequence-specific DNA binding
A6M16_RS03575	COG4122	O-methyltransferase activity
A6M16_RS03580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6M16_RS03590	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6M16_RS03615	COG1476	TRANSCRIPTIONal
A6M16_RS03650	COG1028	Short-chain dehydrogenase reductase Sdr
A6M16_RS03675	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A6M16_RS03680	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6M16_RS03690	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6M16_RS03700	COG3716	PTS system mannose fructose sorbose family IID component
A6M16_RS03710	COG5492	domain, Protein
A6M16_RS03720	COG1609	Transcriptional regulator
A6M16_RS03725	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6M16_RS03730	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6M16_RS03735	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6M16_RS03740	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A6M16_RS03745	COG0372	Belongs to the citrate synthase family
A6M16_RS03750	COG0538	isocitrate dehydrogenase activity
A6M16_RS03755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6M16_RS03790	COG1196	nuclear chromosome segregation
A6M16_RS03795	COG0561	phosphatase activity
A6M16_RS03800	COG0561	phosphatase activity
A6M16_RS03805	COG0552	protein localization to endoplasmic reticulum
A6M16_RS03820	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A6M16_RS03825	COG3689	TIGRFAM TIGR03943 family protein
A6M16_RS03830	COG0701	Predicted permease
A6M16_RS03840	COG1597	lipid kinase activity
A6M16_RS03850	COG0356	it plays a direct role in the translocation of protons across the membrane
A6M16_RS03855	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6M16_RS03860	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6M16_RS03865	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A6M16_RS03870	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6M16_RS03875	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A6M16_RS03880	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6M16_RS03890	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6M16_RS03905	COG2211	Major facilitator Superfamily
A6M16_RS03915	COG3250	beta-galactosidase activity
A6M16_RS03925	COG0800	Aldolase
A6M16_RS03935	COG1312	Catalyzes the dehydration of D-mannonate
A6M16_RS03940	COG1028	Short-chain dehydrogenase reductase Sdr
A6M16_RS03970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6M16_RS03970	COG0072	phenylalanine-tRNA ligase activity
A6M16_RS03995	COG1051	belongs to the nudix hydrolase family
A6M16_RS04000	COG0302	gtp cyclohydrolase
A6M16_RS04020	COG2610	gluconate transmembrane transporter activity
A6M16_RS04025	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A6M16_RS04040	COG1846	Transcriptional regulator
A6M16_RS04045	COG3759	membrane
A6M16_RS04080	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6M16_RS04085	COG0561	phosphatase activity
A6M16_RS04120	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6M16_RS04125	COG0196	riboflavin kinase activity
A6M16_RS04130	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A6M16_RS04135	COG1393	Belongs to the ArsC family
A6M16_RS04140	COG4476	Belongs to the UPF0223 family
A6M16_RS04145	COG0483	inositol monophosphate 1-phosphatase activity
A6M16_RS04150	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6M16_RS04150	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A6M16_RS04160	COG0573	inorganic phosphate transmembrane transporter activity
A6M16_RS04165	COG0581	inorganic phosphate transmembrane transporter activity
A6M16_RS04170	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6M16_RS04175	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6M16_RS04180	COG0704	Plays a role in the regulation of phosphate uptake
A6M16_RS04190	COG0745	RESPONSE REGULATOR receiver
A6M16_RS04195	COG5002	protein histidine kinase activity
A6M16_RS04210	COG0268	Binds directly to 16S ribosomal RNA
A6M16_RS04215	COG1072	(Pantothenic acid kinase))
A6M16_RS04220	COG2813	Specifically methylates the guanine in position
A6M16_RS04225	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A6M16_RS04235	COG0295	cytidine deaminase activity
A6M16_RS04240	COG1744	ABC transporter substrate-binding protein PnrA-like
A6M16_RS04245	COG3845	ABC transporter
A6M16_RS04250	COG4603	Belongs to the binding-protein-dependent transport system permease family
A6M16_RS04255	COG1079	Belongs to the binding-protein-dependent transport system permease family
A6M16_RS04260	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A6M16_RS04265	COG0039	L-malate dehydrogenase activity
A6M16_RS04270	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6M16_RS04275	COG3764	Sortase (surface protein transpeptidase)
A6M16_RS04285	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A6M16_RS04290	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A6M16_RS04305	COG1104	cysteine desulfurase activity
A6M16_RS04315	COG4116	CYTH
A6M16_RS04320	COG2357	RelA SpoT domain protein
A6M16_RS04325	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A6M16_RS04330	COG0564	pseudouridine synthase activity
A6M16_RS04335	COG0280	phosphate acetyltransferase
A6M16_RS04340	COG1132	(ABC) transporter
A6M16_RS04345	COG1132	(ABC) transporter
A6M16_RS04355	COG1194	a g-specific adenine glycosylase
A6M16_RS04360	COG1396	sequence-specific DNA binding
A6M16_RS04390	COG1349	DNA-binding transcription factor activity
A6M16_RS04395	COG0698	ribose 5-phosphate isomerase
A6M16_RS04400	COG0698	ribose 5-phosphate isomerase
A6M16_RS04405	COG1105	Belongs to the carbohydrate kinase PfkB family
A6M16_RS04410	COG3684	Belongs to the aldolase LacD family
A6M16_RS04415	COG3711	transcriptional antiterminator
A6M16_RS04425	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6M16_RS04425	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6M16_RS04450	COG2873	o-acetylhomoserine
A6M16_RS04455	COG0488	(ABC) transporter
A6M16_RS04465	COG1126	abc transporter atp-binding protein
A6M16_RS04480	COG3583	domain protein
A6M16_RS04605	COG3344	reverse transcriptase
A6M16_RS04620	COG1132	(ABC) transporter
A6M16_RS04710	COG1475	DNA binding
A6M16_RS04715	COG4443	Transcriptional Coactivator p15 (PC4)
A6M16_RS04805	COG3843	relaxase mobilization nuclease domain protein
A6M16_RS04835	COG1136	(ABC) transporter
A6M16_RS04850	COG2197	response regulator
A6M16_RS04855	COG1396	sequence-specific DNA binding
A6M16_RS04885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6M16_RS04890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6M16_RS04900	COG0297	glycogen (starch) synthase activity
A6M16_RS04905	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A6M16_RS04925	COG0167	dihydroorotate dehydrogenase activity
A6M16_RS04930	COG0284	orotidine-5'-phosphate decarboxylase activity
A6M16_RS04935	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A6M16_RS04945	COG0463	Glycosyl transferase, family 2
A6M16_RS04950	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A6M16_RS04960	COG0737	Belongs to the 5'-nucleotidase family
A6M16_RS04975	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A6M16_RS04980	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A6M16_RS04990	COG1272	protein, Hemolysin III
A6M16_RS05000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6M16_RS05000	COG0425	Belongs to the sulfur carrier protein TusA family
A6M16_RS05005	COG0110	maltose O-acetyltransferase activity
A6M16_RS05010	COG0758	DNA mediated transformation
A6M16_RS05015	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6M16_RS05020	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A6M16_RS05025	COG0222	ribosome binding
A6M16_RS05030	COG0647	UMP catabolic process
A6M16_RS05035	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A6M16_RS05045	COG2382	esterase
A6M16_RS05070	COG1136	(ABC) transporter
A6M16_RS05075	COG0577	efflux transmembrane transporter activity
A6M16_RS05090	COG0745	RESPONSE REGULATOR receiver
A6M16_RS05105	COG4974	Belongs to the 'phage' integrase family
A6M16_RS05125	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6M16_RS05130	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
A6M16_RS05135	COG2188	Transcriptional regulator
A6M16_RS05145	COG4268	DNA restriction-modification system
A6M16_RS05150	COG1401	restriction endodeoxyribonuclease activity
A6M16_RS05175	COG4221	oxidoreductase activity
A6M16_RS05180	COG0741	lytic transglycosylase activity
A6M16_RS05190	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6M16_RS05200	COG0009	L-threonylcarbamoyladenylate synthase
A6M16_RS05205	COG2890	protein-(glutamine-N5) methyltransferase activity
A6M16_RS05210	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A6M16_RS05235	COG0481	GTPase activity
A6M16_RS05255	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A6M16_RS05265	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A6M16_RS05270	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A6M16_RS05285	COG1940	carbohydrate kinase activity
A6M16_RS05300	COG0488	(ABC) transporter
A6M16_RS05305	COG0617	tRNA 3'-terminal CCA addition
A6M16_RS05310	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A6M16_RS05315	COG1307	EDD domain protein, DegV family
A6M16_RS05325	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6M16_RS05325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6M16_RS05325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6M16_RS05330	COG1105	Belongs to the carbohydrate kinase PfkB family
A6M16_RS05335	COG1349	DNA-binding transcription factor activity
A6M16_RS05345	COG0336	Belongs to the RNA methyltransferase TrmD family
A6M16_RS05350	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A6M16_RS05355	COG0534	Mate efflux family protein
A6M16_RS05365	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6M16_RS05370	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A6M16_RS05385	COG1177	transmembrane transport
A6M16_RS05390	COG1176	ABC-type spermidine putrescine transport system, permease component I
A6M16_RS05395	COG3842	ATPase activity
A6M16_RS05400	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6M16_RS05405	COG0083	homoserine kinase activity
A6M16_RS05410	COG0460	homoserine dehydrogenase
A6M16_RS05415	COG0726	polysaccharide deacetylase
A6M16_RS05420	COG1132	(ABC) transporter
A6M16_RS05435	COG0228	four-way junction DNA binding
A6M16_RS05445	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
A6M16_RS05450	COG2521	methyltransferase
A6M16_RS05450	COG2136	Putative SAM-dependent methyltransferase
A6M16_RS05460	COG0505	Belongs to the CarA family
A6M16_RS05465	COG0540	Belongs to the ATCase OTCase family
A6M16_RS05470	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A6M16_RS05480	COG2824	Alkylphosphonate utilization operon protein PhnA
A6M16_RS05485	COG0564	pseudouridine synthase activity
A6M16_RS05505	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A6M16_RS05510	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A6M16_RS05525	COG3843	relaxase mobilization nuclease domain protein
A6M16_RS05655	COG1114	Component of the transport system for branched-chain amino acids
A6M16_RS05660	COG0301	tRNA thio-modification
A6M16_RS05665	COG1104	cysteine desulfurase activity
A6M16_RS05690	COG0539	negative regulation of cytoplasmic translation
A6M16_RS05710	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6M16_RS05720	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6M16_RS05730	COG0187	DNA topoisomerase II activity
A6M16_RS05740	COG1074	ATP-dependent DNA helicase activity
A6M16_RS05745	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A6M16_RS05770	COG1131	(ABC) transporter
A6M16_RS05800	COG1011	Hydrolase
A6M16_RS05810	COG0210	DNA helicase
A6M16_RS05825	COG1164	Oligoendopeptidase f
A6M16_RS05835	COG2801	Transposase and inactivated derivatives
A6M16_RS05845	COG0346	lactoylglutathione lyase activity
A6M16_RS05850	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6M16_RS05855	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A6M16_RS05870	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6M16_RS05875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6M16_RS05880	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6M16_RS05900	COG1882	Formate acetyltransferase
A6M16_RS05905	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6M16_RS05910	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6M16_RS05915	COG1447	Phosphotransferase system cellobiose-specific component IIA
A6M16_RS05925	COG1349	DNA-binding transcription factor activity
A6M16_RS05930	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6M16_RS05960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6M16_RS05970	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A6M16_RS05980	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6M16_RS05985	COG4684	Psort location CytoplasmicMembrane, score
A6M16_RS05990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6M16_RS06010	COG2801	Transposase and inactivated derivatives
A6M16_RS06030	COG0531	amino acid
A6M16_RS06040	COG0708	Exodeoxyribonuclease III
A6M16_RS06050	COG1393	Belongs to the ArsC family
A6M16_RS06055	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6M16_RS06060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6M16_RS06070	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A6M16_RS06080	COG4467	Involved in initiation control of chromosome replication
A6M16_RS06085	COG0470	DNA polymerase III
A6M16_RS06090	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A6M16_RS06095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6M16_RS06110	COG0517	IMP dehydrogenase activity
A6M16_RS06115	COG0658	competence protein
A6M16_RS06115	COG2333	competence protein COMEC
A6M16_RS06120	COG1596	polysaccharide export
A6M16_RS06120	COG1555	photosystem II stabilization
A6M16_RS06125	COG0204	Acyl-transferase
A6M16_RS06130	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6M16_RS06135	COG1120	ATPase activity
A6M16_RS06140	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A6M16_RS06145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6M16_RS06150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6M16_RS06155	COG0386	Belongs to the glutathione peroxidase family
A6M16_RS06160	COG1187	pseudouridine synthase activity
A6M16_RS06165	COG0435	Glutathione S-transferase
A6M16_RS06175	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A6M16_RS06180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6M16_RS06185	COG1696	Membrane protein involved in D-alanine export
A6M16_RS06240	COG1073	alpha beta
A6M16_RS06245	COG0363	glucosamine-6-phosphate deaminase activity
A6M16_RS06250	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A6M16_RS06255	COG1438	arginine binding
A6M16_RS06260	COG3583	domain protein
A6M16_RS06260	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A6M16_RS06260	COG3064	Membrane
A6M16_RS06265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6M16_RS06270	COG1288	antiporter activity
A6M16_RS06275	COG0549	Belongs to the carbamate kinase family
A6M16_RS06280	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6M16_RS06285	COG0454	-acetyltransferase
A6M16_RS06300	COG1481	regulation of sporulation
A6M16_RS06305	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A6M16_RS06310	COG1660	Displays ATPase and GTPase activities
A6M16_RS06315	COG0251	oxidation-reduction process
A6M16_RS06320	COG0534	Mate efflux family protein
A6M16_RS06330	COG0436	Aminotransferase
A6M16_RS06345	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A6M16_RS06355	COG0562	UDP-galactopyranose mutase
A6M16_RS06360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6M16_RS06370	COG0077	Prephenate dehydratase
A6M16_RS06375	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A6M16_RS06400	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A6M16_RS06415	COG3475	LICD family
A6M16_RS06425	COG1216	Glycosyl transferase, family 2
A6M16_RS06440	COG4464	protein tyrosine phosphatase activity
A6M16_RS06450	COG3944	biosynthesis protein
A6M16_RS06455	COG1316	TRANSCRIPTIONal
A6M16_RS06460	COG3022	response to hydroperoxide
A6M16_RS06465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6M16_RS06480	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6M16_RS06485	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A6M16_RS06490	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A6M16_RS06515	COG2801	Transposase and inactivated derivatives
A6M16_RS06525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6M16_RS06530	COG1126	abc transporter atp-binding protein
A6M16_RS06535	COG0765	amino acid transport
A6M16_RS06540	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6M16_RS06550	COG0657	acetylesterase activity
A6M16_RS06550	COG2755	lipolytic protein G-D-S-L family
A6M16_RS06555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6M16_RS06565	COG0469	pyruvate kinase activity
A6M16_RS06570	COG0205	6-phosphofructokinase activity
A6M16_RS06580	COG2188	Transcriptional regulator
A6M16_RS06585	COG1131	(ABC) transporter
A6M16_RS06595	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6M16_RS06635	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A6M16_RS06640	COG1982	Orn Lys Arg decarboxylase major
A6M16_RS06645	COG2151	metal-sulfur cluster biosynthetic enzyme
A6M16_RS06650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6M16_RS06655	COG0358	DNA primase activity
A6M16_RS06660	COG1970	mechanosensitive ion channel activity
A6M16_RS06670	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6M16_RS06675	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A6M16_RS06685	COG0647	UMP catabolic process
A6M16_RS06690	COG1051	belongs to the nudix hydrolase family
A6M16_RS06700	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6M16_RS06710	COG0058	SHG alpha-glucan phosphorylase activity
A6M16_RS06715	COG0813	purine-nucleoside phosphorylase activity
A6M16_RS06720	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A6M16_RS06730	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A6M16_RS06735	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A6M16_RS06750	COG3421	Type III restriction
A6M16_RS06760	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A6M16_RS06775	COG2268	Band 7 protein
A6M16_RS06780	COG1704	LemA family
A6M16_RS06790	COG1573	uracil-dna glycosylase
A6M16_RS06815	COG0488	(ABC) transporter
A6M16_RS06820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6M16_RS06835	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6M16_RS06840	COG3442	glutamine amidotransferase
A6M16_RS06845	COG2226	methyltransferase
A6M16_RS06860	COG0488	(ABC) transporter
A6M16_RS06895	COG3842	ATPase activity
A6M16_RS06915	COG2190	(PTS) system
A6M16_RS06915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6M16_RS06915	COG1263	PTS System
A6M16_RS06920	COG3711	transcriptional antiterminator
A6M16_RS06925	COG1293	RNA-binding protein homologous to eukaryotic snRNP
A6M16_RS06930	COG3527	Alpha-acetolactate decarboxylase
A6M16_RS06940	COG0628	permease
A6M16_RS06945	COG2706	6-phosphogluconolactonase activity
A6M16_RS06955	COG1011	Hydrolase
A6M16_RS06985	COG0560	Phosphoserine phosphatase
A6M16_RS06990	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
A6M16_RS06995	COG0187	DNA topoisomerase II activity
A6M16_RS07000	COG0693	protein deglycase activity
A6M16_RS07005	COG0772	Belongs to the SEDS family
A6M16_RS07025	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A6M16_RS07030	COG0716	FMN binding
A6M16_RS07040	COG1605	Chorismate mutase
A6M16_RS07040	COG0287	Prephenate dehydrogenase
A6M16_RS07045	COG0038	chloride channel
A6M16_RS07055	COG0737	Belongs to the 5'-nucleotidase family
A6M16_RS07060	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A6M16_RS07065	COG1466	dna polymerase III delta subunit
A6M16_RS07100	COG0683	leucine binding
A6M16_RS07115	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A6M16_RS07120	COG0366	Alpha amylase catalytic
A6M16_RS07130	COG0395	ABC-type sugar transport system, permease component
A6M16_RS07135	COG1175	transmembrane transport
A6M16_RS07140	COG1653	transport
A6M16_RS07150	COG2207	Transcriptional regulator
A6M16_RS07155	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A6M16_RS07160	COG0626	cystathionine gamma-synthase activity
A6M16_RS07180	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A6M16_RS07185	COG2827	Endonuclease containing a URI domain
A6M16_RS07205	COG0640	Transcriptional regulator
A6M16_RS07210	COG0513	Belongs to the DEAD box helicase family
A6M16_RS07220	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6M16_RS07260	COG0494	nUDIX hydrolase
A6M16_RS07265	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A6M16_RS07275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6M16_RS07280	COG1028	Short-chain dehydrogenase reductase Sdr
A6M16_RS07325	COG0577	efflux transmembrane transporter activity
A6M16_RS07330	COG1136	(ABC) transporter
A6M16_RS07335	COG2205	protein histidine kinase activity
A6M16_RS07350	COG0436	Aminotransferase
A6M16_RS07360	COG1174	glycine betaine transport
A6M16_RS07365	COG1125	glycine betaine transport
A6M16_RS07365	COG0517	IMP dehydrogenase activity
A6M16_RS07385	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A6M16_RS07390	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A6M16_RS07395	COG1482	cell wall glycoprotein biosynthetic process
A6M16_RS07415	COG4974	Belongs to the 'phage' integrase family
A6M16_RS07425	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A6M16_RS07445	COG3091	SprT-like family
A6M16_RS07450	COG2183	response to ionizing radiation
A6M16_RS07455	COG0656	L-ascorbic acid biosynthetic process
A6M16_RS07465	COG2801	Transposase and inactivated derivatives
A6M16_RS07470	COG4708	membrane
A6M16_RS07475	COG2246	polysaccharide biosynthetic process
A6M16_RS07485	COG0024	Methionine aminopeptidase
A6M16_RS07495	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6M16_RS07500	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6M16_RS07505	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A6M16_RS07510	COG2131	deaminase
A6M16_RS07530	COG1363	Peptidase, m42
A6M16_RS07545	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A6M16_RS07550	COG1956	GAF domain-containing protein
A6M16_RS07560	COG1695	Transcriptional regulator
A6M16_RS07570	COG0673	inositol 2-dehydrogenase activity
A6M16_RS07575	COG0513	Belongs to the DEAD box helicase family
A6M16_RS07580	COG0726	polysaccharide deacetylase
A6M16_RS07595	COG0183	Belongs to the thiolase family
A6M16_RS07600	COG3425	synthase
A6M16_RS07635	COG3422	double-strand break repair
A6M16_RS07665	COG0582	viral genome integration into host DNA
A6M16_RS07670	COG0776	regulation of translation
A6M16_RS07680	COG2755	lipolytic protein G-D-S-L family
A6M16_RS07685	COG1307	EDD domain protein, DegV family
A6M16_RS07690	COG0497	DNA recombination
A6M16_RS07695	COG1438	arginine binding
A6M16_RS07700	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A6M16_RS07710	COG1722	exodeoxyribonuclease VII activity
A6M16_RS07715	COG1570	exodeoxyribonuclease VII activity
A6M16_RS07720	COG2321	neutral zinc metallopeptidase
A6M16_RS07725	COG1755	Isoprenylcysteine carboxyl methyltransferase
A6M16_RS07730	COG5002	protein histidine kinase activity
A6M16_RS07735	COG0745	RESPONSE REGULATOR receiver
A6M16_RS07760	COG1227	inorganic diphosphatase activity
A6M16_RS07770	COG1733	regulation of RNA biosynthetic process
A6M16_RS07795	COG2514	catechol 2,3-dioxygenase activity
A6M16_RS07805	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6M16_RS07810	COG1253	flavin adenine dinucleotide binding
A6M16_RS07815	COG1119	ATPase activity
A6M16_RS07820	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A6M16_RS07845	COG0133	tryptophan synthase activity
A6M16_RS07860	COG4470	Protein conserved in bacteria
A6M16_RS07865	COG3480	Lon protease (S16) C-terminal proteolytic domain
A6M16_RS07870	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A6M16_RS07875	COG0742	ribosomal rna small subunit methyltransferase
A6M16_RS07885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6M16_RS07890	COG4483	Protein conserved in bacteria
A6M16_RS07895	COG2197	response regulator
A6M16_RS07900	COG4585	Histidine kinase
A6M16_RS07905	COG0842	Transport permease protein
A6M16_RS07910	COG1131	(ABC) transporter
A6M16_RS07925	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6M16_RS07935	COG2755	lipolytic protein G-D-S-L family
A6M16_RS07935	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A6M16_RS07940	COG0671	phosphoesterase, PA-phosphatase related
A6M16_RS07945	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A6M16_RS07960	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A6M16_RS07965	COG1187	pseudouridine synthase activity
A6M16_RS07970	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A6M16_RS07975	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A6M16_RS07980	COG0582	viral genome integration into host DNA
A6M16_RS08000	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A6M16_RS08005	COG3763	UPF0154 protein
A6M16_RS08015	COG3579	cysteine-type endopeptidase activity
A6M16_RS08030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6M16_RS08035	COG1254	Belongs to the acylphosphatase family
A6M16_RS08045	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6M16_RS08050	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6M16_RS08070	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6M16_RS08080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A6M16_RS08095	COG1160	GTP binding
A6M16_RS08105	COG1484	DNA-dependent DNA replication
A6M16_RS08115	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A6M16_RS08120	COG0628	permease
A6M16_RS08125	COG0745	RESPONSE REGULATOR receiver
A6M16_RS08130	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A6M16_RS08140	COG0492	ferredoxin-NADP+ reductase activity
A6M16_RS08150	COG0513	Belongs to the DEAD box helicase family
A6M16_RS08170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6M16_RS08175	COG0768	penicillin binding
A6M16_RS08185	COG0275	rRNA processing
A6M16_RS08230	COG4939	FMN-binding domain protein
A6M16_RS08235	COG0142	geranyltranstransferase activity
A6M16_RS08240	COG1252	NADH dehydrogenase
A6M16_RS08255	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6M16_RS08260	COG0569	domain protein
A6M16_RS08265	COG0534	Mate efflux family protein
A6M16_RS08280	COG0751	glycine-tRNA ligase activity
A6M16_RS08310	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6M16_RS08315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6M16_RS08320	COG1464	Belongs to the NlpA lipoprotein family
A6M16_RS08325	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A6M16_RS08330	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A6M16_RS08335	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A6M16_RS08340	COG2252	PERMEase
A6M16_RS08345	COG0561	phosphatase activity
A6M16_RS08355	COG3715	PTS system
A6M16_RS08360	COG3716	PTS system mannose fructose sorbose family IID component
A6M16_RS08375	COG1983	PspC domain protein
A6M16_RS08380	COG1266	CAAX protease self-immunity
A6M16_RS08400	COG0439	Biotin carboxylase
A6M16_RS08415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6M16_RS08420	COG1028	Short-chain dehydrogenase reductase Sdr
A6M16_RS08425	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A6M16_RS08430	COG2070	2-Nitropropane dioxygenase
A6M16_RS08440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6M16_RS08450	COG1024	Enoyl-CoA hydratase
A6M16_RS08455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6M16_RS08460	COG0527	aspartate kinase activity
A6M16_RS08465	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6M16_RS08470	COG0736	holo-[acyl-carrier-protein] synthase activity
A6M16_RS08475	COG0653	protein targeting
A6M16_RS08495	COG1940	carbohydrate kinase activity
A6M16_RS08500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6M16_RS08500	COG1263	PTS System
A6M16_RS08500	COG2190	(PTS) system
A6M16_RS08505	COG1621	beta-fructofuranosidase activity
A6M16_RS08510	COG1609	Transcriptional regulator
A6M16_RS08515	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6M16_RS08530	COG0006	proline dipeptidase activity
A6M16_RS08550	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6M16_RS08570	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A6M16_RS08575	COG0629	single-stranded DNA binding
A6M16_RS08585	COG0095	Lipoate-protein ligase
A6M16_RS08590	COG2723	6-phospho-beta-galactosidase activity
A6M16_RS08605	COG2723	6-phospho-beta-galactosidase activity
A6M16_RS08610	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6M16_RS08620	COG1447	Phosphotransferase system cellobiose-specific component IIA
A6M16_RS08625	COG3711	transcriptional antiterminator
A6M16_RS08625	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6M16_RS08640	COG4095	Psort location CytoplasmicMembrane, score
A6M16_RS08645	COG2723	6-phospho-beta-galactosidase activity
A6M16_RS08650	COG0346	lactoylglutathione lyase activity
A6M16_RS08655	COG2723	6-phospho-beta-galactosidase activity
A6M16_RS08660	COG1917	Cupin 2, conserved barrel domain protein
A6M16_RS08660	COG2207	Transcriptional regulator
A6M16_RS08670	COG1263	PTS System
A6M16_RS08670	COG2190	(PTS) system
A6M16_RS08670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6M16_RS08675	COG3711	transcriptional antiterminator
A6M16_RS08690	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6M16_RS08695	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6M16_RS08695	COG0022	dehydrogenase e1 component
A6M16_RS08700	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A6M16_RS08705	COG2860	membrane
A6M16_RS08720	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A6M16_RS08725	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A6M16_RS08735	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A6M16_RS08740	COG0195	Participates in both transcription termination and antitermination
A6M16_RS08750	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6M16_RS08760	COG4473	ABC transporter
A6M16_RS08765	COG1131	(ABC) transporter
A6M16_RS08770	COG0537	adenosine 5'-monophosphoramidase activity
A6M16_RS08780	COG1316	TRANSCRIPTIONal
A6M16_RS08790	COG0802	atpase or kinase
A6M16_RS08795	COG1461	Dihydroxyacetone kinase
A6M16_RS08810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6M16_RS08815	COG0601	transmembrane transport
A6M16_RS08820	COG4608	Belongs to the ABC transporter superfamily
A6M16_RS08835	COG1686	Belongs to the peptidase S11 family
A6M16_RS08850	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6M16_RS08855	COG0719	Fe-S assembly protein
A6M16_RS08865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6M16_RS08870	COG4862	establishment of competence for transformation
A6M16_RS08875	COG1968	undecaprenyl-diphosphatase activity
A6M16_RS08880	COG0765	amino acid transport
A6M16_RS08900	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A6M16_RS08905	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A6M16_RS08910	COG0440	acetolactate synthase activity
A6M16_RS08915	COG0028	Belongs to the TPP enzyme family
A6M16_RS08920	COG0463	Glycosyl transferase, family 2
A6M16_RS08935	COG0129	dihydroxy-acid dehydratase activity
A6M16_RS08945	COG2151	metal-sulfur cluster biosynthetic enzyme
A6M16_RS08970	COG1674	ftsk spoiiie
A6M16_RS09005	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A6M16_RS09020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6M16_RS09035	COG3842	ATPase activity
A6M16_RS09045	COG2207	Transcriptional regulator
A6M16_RS09045	COG4753	response regulator
A6M16_RS09050	COG2972	Histidine kinase
A6M16_RS09060	COG1653	transport
A6M16_RS09065	COG0395	ABC-type sugar transport system, permease component
A6M16_RS09070	COG1175	transmembrane transport
A6M16_RS09085	COG0383	alpha-mannosidase activity
A6M16_RS09105	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
A6M16_RS09125	COG1045	serine acetyltransferase
A6M16_RS09130	COG1185	polyribonucleotide nucleotidyltransferase activity
A6M16_RS09135	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A6M16_RS09180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6M16_RS09185	COG1187	pseudouridine synthase activity
A6M16_RS09200	COG0242	peptide deformylase activity
A6M16_RS09210	COG0066	3-isopropylmalate dehydratase activity
A6M16_RS09215	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A6M16_RS09240	COG3590	peptidase
A6M16_RS09255	COG2309	aminopeptidase activity
A6M16_RS09265	COG2176	DNA-directed DNA polymerase activity
A6M16_RS09270	COG2376	Dihydroxyacetone kinase
A6M16_RS09280	COG2376	Dihydroxyacetone kinase
A6M16_RS09285	COG1461	Dihydroxyacetone kinase
A6M16_RS09290	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
A6M16_RS09295	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6M16_RS09305	COG2801	Transposase and inactivated derivatives
A6M16_RS09310	COG0442	prolyl-tRNA aminoacylation
A6M16_RS09320	COG4589	Belongs to the CDS family
A6M16_RS09325	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6M16_RS09330	COG1862	Preprotein translocase
A6M16_RS09340	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6M16_RS09340	COG2918	glutathione biosynthetic process
A6M16_RS09350	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A6M16_RS09355	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6M16_RS09360	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A6M16_RS09365	COG0542	response to heat
A6M16_RS09370	COG4463	regulation of RNA biosynthetic process
A6M16_RS09380	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A6M16_RS09415	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6M16_RS09420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6M16_RS09425	COG0492	ferredoxin-NADP+ reductase activity
A6M16_RS09430	COG0564	pseudouridine synthase activity
A6M16_RS09530	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6M16_RS09550	COG1564	THIamine pyrophosphokinase
A6M16_RS09560	COG1162	GTPase activity
A6M16_RS09595	COG4115	mRNA cleavage
A6M16_RS09620	COG0084	hydrolase, TatD family'
A6M16_RS09630	COG1847	R3H domain protein
A6M16_RS09640	COG0594	ribonuclease P activity
A6M16_RS09645	COG0165	Argininosuccinate lyase
A6M16_RS09650	COG0137	argininosuccinate synthase activity
A6M16_RS09660	COG1827	regulation of RNA biosynthetic process
A6M16_RS09675	COG2040	homocysteine
A6M16_RS09680	COG0833	amino acid
A6M16_RS09725	COG0756	dUTP diphosphatase activity
A6M16_RS09735	COG2832	Protein of unknown function (DUF454)
A6M16_RS09745	COG3976	FMN-binding domain protein
A6M16_RS09745	COG1053	succinate dehydrogenase
A6M16_RS09745	COG0431	NADPH-dependent FMN reductase
A6M16_RS09760	COG1132	(ABC) transporter
A6M16_RS09765	COG1132	(ABC) transporter
A6M16_RS09775	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A6M16_RS09780	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A6M16_RS09785	COG0705	Rhomboid family
A6M16_RS09790	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6M16_RS09795	COG1473	amidohydrolase
A6M16_RS09800	COG2171	N-acyltransferase activity
A6M16_RS09815	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A6M16_RS09840	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A6M16_RS09865	COG3623	hexulose-6-phosphate isomerase
A6M16_RS09890	COG1523	belongs to the glycosyl hydrolase 13 family
A6M16_RS09905	COG0463	Glycosyl transferase, family 2
A6M16_RS09920	COG1609	Transcriptional regulator
A6M16_RS09925	COG1126	abc transporter atp-binding protein
A6M16_RS09930	COG0765	amino acid transport
A6M16_RS09935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6M16_RS09945	COG2801	Transposase and inactivated derivatives
A6M16_RS09950	COG3942	CHAP domain
A6M16_RS09955	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6M16_RS09965	COG1447	Phosphotransferase system cellobiose-specific component IIA
A6M16_RS09975	COG3711	transcriptional antiterminator
A6M16_RS09975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6M16_RS09985	COG2723	6-phospho-beta-galactosidase activity
A6M16_RS09990	COG1486	melibiose metabolic process
A6M16_RS10000	COG4667	esterase of the alpha-beta hydrolase superfamily
A6M16_RS10005	COG3590	peptidase
A6M16_RS10010	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6M16_RS10015	COG1321	iron dependent repressor
A6M16_RS10015	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6M16_RS10020	COG1121	(ABC) transporter
A6M16_RS10035	COG0803	Belongs to the bacterial solute-binding protein 9 family
A6M16_RS10055	COG1490	D-aminoacyl-tRNA deacylase activity
A6M16_RS10065	COG0737	Belongs to the 5'-nucleotidase family
A6M16_RS10085	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6M16_RS10110	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6M16_RS10140	COG0737	Belongs to the 5'-nucleotidase family
A6M16_RS10150	COG1328	CTP reductase activity
A6M16_RS10155	COG1126	abc transporter atp-binding protein
A6M16_RS10165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6M16_RS10170	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A6M16_RS10185	COG1438	arginine binding
A6M16_RS10190	COG0018	arginyl-trna synthetase
A6M16_RS10210	COG1640	4-alpha-glucanotransferase
A6M16_RS10215	COG2182	Extracellular solute-binding protein
A6M16_RS10220	COG1175	transmembrane transport
A6M16_RS10225	COG3833	ABC-type maltose transport systems, permease component
A6M16_RS10230	COG5521	maltodextrose utilization protein MalA
A6M16_RS10240	COG1523	belongs to the glycosyl hydrolase 13 family
A6M16_RS10245	COG1780	Probably involved in ribonucleotide reductase function
A6M16_RS10250	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6M16_RS10255	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A6M16_RS10260	COG2153	protein acetylation
A6M16_RS10265	COG4989	oxidoreductase activity
A6M16_RS10270	COG1216	Glycosyl transferase, family 2
A6M16_RS10290	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A6M16_RS10300	COG0305	Participates in initiation and elongation during chromosome replication
A6M16_RS10305	COG0359	binds to the 23S rRNA
A6M16_RS10315	COG0445	tRNA wobble uridine modification
A6M16_RS10320	COG0494	nUDIX hydrolase
A6M16_RS10325	COG0494	nUDIX hydrolase
A6M16_RS10330	COG1733	regulation of RNA biosynthetic process
A6M16_RS10340	COG0482	sulfurtransferase activity
A6M16_RS10345	COG1760	l-serine dehydratase
A6M16_RS10350	COG1760	l-serine dehydratase
A6M16_RS10360	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A6M16_RS10365	COG1122	ATPase activity
A6M16_RS10370	COG1122	ATPase activity
A6M16_RS10375	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6M16_RS10380	COG1426	Protein conserved in bacteria
A6M16_RS10385	COG0612	Peptidase, M16
A6M16_RS10390	COG0612	Peptidase, M16
A6M16_RS10400	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6M16_RS10405	COG0517	IMP dehydrogenase activity
A6M16_RS10405	COG0516	GMP reductase activity
A6M16_RS10415	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6M16_RS10420	COG0488	(ABC) transporter
A6M16_RS10450	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A6M16_RS10455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6M16_RS10460	COG1475	DNA binding