locus-tag	class	description
DF184_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DF184_RS00010	COG0592	DNA-directed DNA polymerase activity
DF184_RS00030	COG0012	GTP binding
DF184_RS00035	COG0193	aminoacyl-tRNA hydrolase activity
DF184_RS00040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DF184_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DF184_RS00065	COG0037	tRNA processing
DF184_RS00075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DF184_RS00190	COG1792	Involved in formation and maintenance of cell shape
DF184_RS00205	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DF184_RS00210	COG0436	Aminotransferase
DF184_RS00215	COG1381	Involved in DNA repair and RecF pathway recombination
DF184_RS00220	COG0416	fatty acid biosynthetic process
DF184_RS00225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DF184_RS00235	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DF184_RS00250	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DF184_RS00255	COG0138	bifunctional purine biosynthesis protein purh
DF184_RS00265	COG0151	Belongs to the GarS family
DF184_RS00270	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DF184_RS00285	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DF184_RS00305	COG1132	(ABC) transporter
DF184_RS00310	COG2255	four-way junction helicase activity
DF184_RS00320	COG0546	phosphoglycolate phosphatase activity
DF184_RS00340	COG0285	dihydrofolate synthase activity
DF184_RS00355	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DF184_RS00360	COG0632	four-way junction helicase activity
DF184_RS00365	COG0519	Catalyzes the synthesis of GMP from XMP
DF184_RS00380	COG1393	Belongs to the ArsC family
DF184_RS00385	COG4472	Bacterial protein of unknown function (DUF965)
DF184_RS00390	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DF184_RS00395	COG3906	Belongs to the UPF0473 family
DF184_RS00410	COG0051	transcription antitermination factor activity, RNA binding
DF184_RS00415	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DF184_RS00420	COG0088	Forms part of the polypeptide exit tunnel
DF184_RS00425	COG0089	rRNA binding
DF184_RS00430	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DF184_RS00435	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DF184_RS00440	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DF184_RS00445	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DF184_RS00450	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DF184_RS00455	COG0255	Belongs to the universal ribosomal protein uL29 family
DF184_RS00460	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DF184_RS00465	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DF184_RS00470	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DF184_RS00475	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DF184_RS00480	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DF184_RS00485	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DF184_RS00490	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DF184_RS00495	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DF184_RS00500	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DF184_RS00505	COG1841	ribosomal large subunit assembly
DF184_RS00515	COG0201	protein transport
DF184_RS00520	COG0563	adenylate kinase activity
DF184_RS00525	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DF184_RS00530	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DF184_RS00535	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DF184_RS00545	COG0202	RNA polymerase activity
DF184_RS00660	COG1121	(ABC) transporter
DF184_RS00665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DF184_RS00670	COG0803	Belongs to the bacterial solute-binding protein 9 family
DF184_RS00670	COG3443	Belongs to the bacterial solute-binding protein 9 family
DF184_RS00715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DF184_RS00720	COG0085	RNA polymerase activity
DF184_RS00725	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DF184_RS00735	COG1619	proteins homologs of microcin C7 resistance protein MccF
DF184_RS00740	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DF184_RS00745	COG1459	type II secretion system
DF184_RS00750	COG4537	Required for transformation and DNA binding
DF184_RS00780	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DF184_RS00790	COG0285	dihydrofolate synthase activity
DF184_RS00795	COG1363	Peptidase, m42
DF184_RS00805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DF184_RS00815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DF184_RS00840	COG0459	protein refolding
DF184_RS00850	COG0049	tRNA binding
DF184_RS00860	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DF184_RS00870	COG0126	phosphoglycerate kinase activity
DF184_RS00885	COG0789	Transcriptional regulator
DF184_RS00890	COG0174	glutamine synthetase
DF184_RS00905	COG1396	sequence-specific DNA binding
DF184_RS00925	COG1214	PFAM Peptidase M22, glycoprotease
DF184_RS00935	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DF184_RS00940	COG2207	Transcriptional regulator
DF184_RS00950	COG1175	transmembrane transport
DF184_RS00955	COG0395	ABC-type sugar transport system, permease component
DF184_RS00975	COG2855	membrane
DF184_RS00985	COG1846	Transcriptional regulator
DF184_RS00985	COG0456	acetyltransferase
DF184_RS01000	COG1131	(ABC) transporter
DF184_RS01005	COG2081	HI0933 family
DF184_RS01010	COG2723	6-phospho-beta-galactosidase activity
DF184_RS01020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DF184_RS01035	COG3959	Transketolase, thiamine diphosphate binding domain
DF184_RS01040	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DF184_RS01045	COG0584	glycerophosphoryl diester phosphodiesterase
DF184_RS01050	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DF184_RS01060	COG2222	sugar isomerase
DF184_RS01085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DF184_RS01095	COG3942	CHAP domain
DF184_RS01100	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DF184_RS01145	COG1882	Formate acetyltransferase
DF184_RS01160	COG2910	NAD(P)H-binding
DF184_RS01175	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DF184_RS01180	COG0681	Belongs to the peptidase S26 family
DF184_RS01205	COG0366	Alpha amylase catalytic
DF184_RS01210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DF184_RS01210	COG1263	PTS System
DF184_RS01215	COG2188	Transcriptional regulator
DF184_RS01230	COG1193	negative regulation of DNA recombination
DF184_RS01245	COG0656	L-ascorbic acid biosynthetic process
DF184_RS01250	COG3118	belongs to the thioredoxin family
DF184_RS01255	COG0318	PFAM AMP-dependent synthetase and ligase
DF184_RS01260	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DF184_RS01260	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DF184_RS01275	COG1115	amino acid carrier protein
DF184_RS01295	COG0668	transmembrane transport
DF184_RS01305	COG3547	Transposase (IS116 IS110 IS902 family)
DF184_RS01310	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DF184_RS01320	COG0167	dihydroorotate dehydrogenase activity
DF184_RS01345	COG4555	ABC transporter
DF184_RS01350	COG1309	transcriptional regulator
DF184_RS01355	COG1511	domain protein
DF184_RS01355	COG1511	domain protein
DF184_RS01380	COG1346	cytolysis
DF184_RS01385	COG2116	formate transmembrane transporter activity
DF184_RS01390	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DF184_RS01395	COG0433	COG0433 Predicted ATPase
DF184_RS01400	COG0494	nUDIX hydrolase
DF184_RS01415	COG1349	DNA-binding transcription factor activity
DF184_RS01425	COG0698	ribose 5-phosphate isomerase
DF184_RS01430	COG0698	ribose 5-phosphate isomerase
DF184_RS01435	COG1105	Belongs to the carbohydrate kinase PfkB family
DF184_RS01440	COG3684	Belongs to the aldolase LacD family
DF184_RS01445	COG3711	transcriptional antiterminator
DF184_RS01455	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DF184_RS01455	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DF184_RS01470	COG1408	metallophosphoesterase
DF184_RS01475	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DF184_RS01480	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DF184_RS01485	COG0124	histidyl-tRNA synthetase
DF184_RS01490	COG1064	alcohol dehydrogenase
DF184_RS01495	COG1012	belongs to the aldehyde dehydrogenase family
DF184_RS01495	COG1454	alcohol dehydrogenase
DF184_RS01505	COG4988	ABC transporter
DF184_RS01510	COG1132	(ABC) transporter
DF184_RS01525	COG1129	ABC transporter
DF184_RS01530	COG0534	Mate efflux family protein
DF184_RS01535	COG1132	(ABC) transporter
DF184_RS01560	COG1304	FMN binding
DF184_RS01565	COG1132	(ABC) transporter
DF184_RS01570	COG1132	(ABC) transporter
DF184_RS01575	COG3830	Belongs to the UPF0237 family
DF184_RS01580	COG2848	UPF0210 protein
DF184_RS01585	COG0588	phosphoglycerate mutase activity
DF184_RS01600	COG1396	sequence-specific DNA binding
DF184_RS01620	COG1420	regulation of RNA biosynthetic process
DF184_RS01625	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DF184_RS01630	COG0443	Heat shock 70 kDa protein
DF184_RS01635	COG0484	heat shock protein binding
DF184_RS01640	COG0095	Lipoate-protein ligase
DF184_RS01650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DF184_RS01655	COG0765	amino acid transport
DF184_RS01660	COG3655	Transcriptional regulator
DF184_RS01670	COG2217	Heavy metal translocating P-type atpase
DF184_RS01685	COG0351	phosphomethylpyrimidine kinase
DF184_RS01695	COG4475	Protein of unknown function (DUF436)
DF184_RS01705	COG1064	alcohol dehydrogenase
DF184_RS01720	COG0544	peptidyl-prolyl cis-trans isomerase activity
DF184_RS01725	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DF184_RS01735	COG0251	oxidation-reduction process
DF184_RS01740	COG0626	cystathionine gamma-synthase activity
DF184_RS01745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DF184_RS01750	COG2964	Protein conserved in bacteria
DF184_RS01775	COG1215	transferase activity, transferring glycosyl groups
DF184_RS01790	COG3343	RNA polymerase activity
DF184_RS01795	COG0504	CTP synthase activity
DF184_RS01805	COG0191	fructose-bisphosphate aldolase activity
DF184_RS01810	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DF184_RS01855	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DF184_RS01880	COG0589	response to stress
DF184_RS01885	COG0436	Aminotransferase
DF184_RS01890	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DF184_RS01895	COG1335	isochorismatase
DF184_RS01900	COG0335	large ribosomal subunit rRNA binding
DF184_RS01910	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DF184_RS01915	COG0154	amidase activity
DF184_RS01920	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DF184_RS01925	COG1609	Transcriptional regulator
DF184_RS01930	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DF184_RS01935	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
DF184_RS01945	COG3142	Participates in the control of copper homeostasis
DF184_RS01960	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DF184_RS01965	COG1534	Rna-binding protein
DF184_RS01970	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DF184_RS01975	COG1713	HD superfamily hydrolase involved in NAD metabolism
DF184_RS01990	COG1335	isochorismatase
DF184_RS01995	COG0799	negative regulation of ribosome biogenesis
DF184_RS02005	COG2226	methyltransferase
DF184_RS02015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DF184_RS02020	COG0789	Transcriptional regulator
DF184_RS02030	COG0242	peptide deformylase activity
DF184_RS02040	COG1640	4-alpha-glucanotransferase
DF184_RS02045	COG0058	SHG alpha-glucan phosphorylase activity
DF184_RS02060	COG1263	PTS System
DF184_RS02060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DF184_RS02060	COG2190	(PTS) system
DF184_RS02065	COG0217	transcriptional regulatory protein
DF184_RS02075	COG4720	Psort location CytoplasmicMembrane, score
DF184_RS02085	COG1054	Belongs to the UPF0176 family
DF184_RS02095	COG1122	ATPase activity
DF184_RS02110	COG0357	Ribosomal RNA small subunit methyltransferase G
DF184_RS02115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DF184_RS02120	COG3331	DNA recombination
DF184_RS02125	COG4474	Belongs to the UPF0398 family
DF184_RS02130	COG3599	regulation of cell shape
DF184_RS02140	COG0116	Belongs to the methyltransferase superfamily
DF184_RS02150	COG1854	S-ribosylhomocysteine lyase activity
DF184_RS02155	COG1418	mRNA catabolic process
DF184_RS02165	COG1758	RNA polymerase activity
DF184_RS02170	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DF184_RS02175	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DF184_RS02180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DF184_RS02180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DF184_RS02185	COG0631	protein serine/threonine phosphatase activity
DF184_RS02190	COG0515	serine threonine protein kinase
DF184_RS02190	COG2815	serine threonine protein kinase
DF184_RS02215	COG1098	S1 RNA binding domain
DF184_RS02225	COG1739	Uncharacterized protein family UPF0029
DF184_RS02230	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DF184_RS02330	COG2217	Heavy metal translocating P-type atpase
DF184_RS02340	COG2132	Multicopper oxidase
DF184_RS02375	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DF184_RS02385	COG3557	Belongs to the UPF0374 family
DF184_RS02395	COG2188	Transcriptional regulator
DF184_RS02400	COG2188	Transcriptional regulator
DF184_RS02410	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DF184_RS02420	COG3716	PTS system mannose fructose sorbose family IID component
DF184_RS02430	COG2017	converts alpha-aldose to the beta-anomer
DF184_RS02445	COG0346	lactoylglutathione lyase activity
DF184_RS02500	COG1217	gtp-binding protein TYPA
DF184_RS02515	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DF184_RS02535	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DF184_RS02540	COG1799	cell septum assembly
DF184_RS02555	COG3599	regulation of cell shape
DF184_RS02575	COG0494	nUDIX hydrolase
DF184_RS02575	COG0406	alpha-ribazole phosphatase activity
DF184_RS02580	COG0542	response to heat
DF184_RS02585	COG4703	Protein of unknown function (DUF1797)
DF184_RS02590	COG0765	amino acid transport
DF184_RS02600	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DF184_RS02625	COG3590	peptidase
DF184_RS02640	COG0745	RESPONSE REGULATOR receiver
DF184_RS02645	COG3850	Histidine kinase
DF184_RS02645	COG5002	protein histidine kinase activity
DF184_RS02650	COG1755	Isoprenylcysteine carboxyl methyltransferase
DF184_RS02660	COG1755	Isoprenylcysteine carboxyl methyltransferase
DF184_RS02670	COG2321	neutral zinc metallopeptidase
DF184_RS02675	COG1570	exodeoxyribonuclease VII activity
DF184_RS02680	COG1722	exodeoxyribonuclease VII activity
DF184_RS02690	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DF184_RS02695	COG1438	arginine binding
DF184_RS02700	COG0497	DNA recombination
DF184_RS02705	COG1307	EDD domain protein, DegV family
DF184_RS02710	COG2755	lipolytic protein G-D-S-L family
DF184_RS02720	COG0776	regulation of translation
DF184_RS02740	COG3425	synthase
DF184_RS02745	COG0183	Belongs to the thiolase family
DF184_RS02760	COG0726	polysaccharide deacetylase
DF184_RS02765	COG0513	Belongs to the DEAD box helicase family
DF184_RS02770	COG0673	inositol 2-dehydrogenase activity
DF184_RS02780	COG1695	Transcriptional regulator
DF184_RS02790	COG1956	GAF domain-containing protein
DF184_RS02795	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DF184_RS02810	COG1363	Peptidase, m42
DF184_RS02820	COG2131	deaminase
DF184_RS02830	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DF184_RS02835	COG2249	NAD(P)H dehydrogenase (quinone) activity
DF184_RS02840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DF184_RS02850	COG0024	Methionine aminopeptidase
DF184_RS02860	COG2246	polysaccharide biosynthetic process
DF184_RS02865	COG4708	membrane
DF184_RS02870	COG0656	L-ascorbic acid biosynthetic process
DF184_RS02875	COG2183	response to ionizing radiation
DF184_RS02880	COG3091	SprT-like family
DF184_RS02895	COG1482	cell wall glycoprotein biosynthetic process
DF184_RS02900	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DF184_RS02905	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DF184_RS02920	COG1733	regulation of RNA biosynthetic process
DF184_RS02945	COG0517	IMP dehydrogenase activity
DF184_RS02945	COG1125	glycine betaine transport
DF184_RS02950	COG1174	glycine betaine transport
DF184_RS02960	COG0436	Aminotransferase
DF184_RS02975	COG2205	protein histidine kinase activity
DF184_RS02980	COG1136	(ABC) transporter
DF184_RS02985	COG0577	efflux transmembrane transporter activity
DF184_RS03015	COG1028	Short-chain dehydrogenase reductase Sdr
DF184_RS03020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DF184_RS03035	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DF184_RS03040	COG0494	nUDIX hydrolase
DF184_RS03080	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DF184_RS03105	COG4209	transmembrane transport
DF184_RS03110	COG0395	ABC-type sugar transport system, permease component
DF184_RS03115	COG1653	transport
DF184_RS03120	COG1621	beta-fructofuranosidase activity
DF184_RS03125	COG1674	ftsk spoiiie
DF184_RS03125	COG0697	spore germination
DF184_RS03130	COG0346	lactoylglutathione lyase activity
DF184_RS03155	COG0625	glutathione transferase activity
DF184_RS03165	COG2244	polysaccharide biosynthetic process
DF184_RS03170	COG0528	UMP kinase activity
DF184_RS03175	COG0233	cytoplasmic translational termination
DF184_RS03180	COG2996	Protein conserved in bacteria
DF184_RS03195	COG4479	Belongs to the UPF0346 family
DF184_RS03200	COG1702	phosphate starvation-inducible protein PhoH
DF184_RS03220	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DF184_RS03225	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DF184_RS03230	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DF184_RS03245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DF184_RS03250	COG3022	response to hydroperoxide
DF184_RS03255	COG1316	TRANSCRIPTIONal
DF184_RS03260	COG3944	biosynthesis protein
DF184_RS03270	COG4464	protein tyrosine phosphatase activity
DF184_RS03280	COG3177	Filamentation induced by cAMP protein fic
DF184_RS03285	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DF184_RS03290	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DF184_RS03295	COG1216	Glycosyl transferase, family 2
DF184_RS03305	COG0438	transferase activity, transferring glycosyl groups
DF184_RS03310	COG0438	transferase activity, transferring glycosyl groups
DF184_RS03345	COG0562	UDP-galactopyranose mutase
DF184_RS03350	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DF184_RS03365	COG0436	Aminotransferase
DF184_RS03375	COG0534	Mate efflux family protein
DF184_RS03380	COG0251	oxidation-reduction process
DF184_RS03385	COG1660	Displays ATPase and GTPase activities
DF184_RS03390	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DF184_RS03395	COG1481	regulation of sporulation
DF184_RS03410	COG0454	-acetyltransferase
DF184_RS03415	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DF184_RS03420	COG0549	Belongs to the carbamate kinase family
DF184_RS03425	COG1288	antiporter activity
DF184_RS03430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DF184_RS03435	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DF184_RS03435	COG3583	domain protein
DF184_RS03435	COG3064	Membrane
DF184_RS03440	COG1438	arginine binding
DF184_RS03445	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DF184_RS03450	COG0363	glucosamine-6-phosphate deaminase activity
DF184_RS03475	COG1696	Membrane protein involved in D-alanine export
DF184_RS03480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DF184_RS03485	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DF184_RS03495	COG0435	Glutathione S-transferase
DF184_RS03500	COG1187	pseudouridine synthase activity
DF184_RS03505	COG0386	Belongs to the glutathione peroxidase family
DF184_RS03510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DF184_RS03515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DF184_RS03520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DF184_RS03525	COG1120	ATPase activity
DF184_RS03530	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DF184_RS03535	COG0204	Acyl-transferase
DF184_RS03540	COG1555	photosystem II stabilization
DF184_RS03540	COG1596	polysaccharide export
DF184_RS03545	COG0658	competence protein
DF184_RS03545	COG2333	competence protein COMEC
DF184_RS03550	COG1466	dna polymerase III delta subunit
DF184_RS03555	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DF184_RS03560	COG0737	Belongs to the 5'-nucleotidase family
DF184_RS03580	COG0038	chloride channel
DF184_RS03585	COG1605	Chorismate mutase
DF184_RS03585	COG0287	Prephenate dehydrogenase
DF184_RS03595	COG0716	FMN binding
DF184_RS03600	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DF184_RS03615	COG0772	Belongs to the SEDS family
DF184_RS03620	COG0693	protein deglycase activity
DF184_RS03625	COG0187	DNA topoisomerase II activity
DF184_RS03630	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
DF184_RS03635	COG0560	Phosphoserine phosphatase
DF184_RS03660	COG1011	Hydrolase
DF184_RS03670	COG2706	6-phosphogluconolactonase activity
DF184_RS03675	COG0628	permease
DF184_RS03685	COG3527	Alpha-acetolactate decarboxylase
DF184_RS03690	COG1293	RNA-binding protein homologous to eukaryotic snRNP
DF184_RS03705	COG3842	ATPase activity
DF184_RS03740	COG0488	(ABC) transporter
DF184_RS03750	COG2226	methyltransferase
DF184_RS03760	COG3442	glutamine amidotransferase
DF184_RS03765	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DF184_RS03780	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DF184_RS03785	COG0488	(ABC) transporter
DF184_RS03790	COG2226	methyltransferase
DF184_RS03825	COG1573	uracil-dna glycosylase
DF184_RS03835	COG1704	LemA family
DF184_RS03840	COG2268	Band 7 protein
DF184_RS03855	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DF184_RS03870	COG0732	type I restriction modification DNA specificity domain
DF184_RS03875	COG4974	Belongs to the 'phage' integrase family
DF184_RS03885	COG0732	type I restriction modification DNA specificity domain
DF184_RS03890	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DF184_RS03895	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DF184_RS03900	COG1393	Belongs to the ArsC family
DF184_RS03905	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DF184_RS03910	COG0813	purine-nucleoside phosphorylase activity
DF184_RS03915	COG0058	SHG alpha-glucan phosphorylase activity
DF184_RS03925	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DF184_RS03935	COG1051	belongs to the nudix hydrolase family
DF184_RS03940	COG0647	UMP catabolic process
DF184_RS03950	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DF184_RS03955	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DF184_RS03960	COG1970	mechanosensitive ion channel activity
DF184_RS03965	COG0358	DNA primase activity
DF184_RS03970	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DF184_RS03975	COG2151	metal-sulfur cluster biosynthetic enzyme
DF184_RS03980	COG1982	Orn Lys Arg decarboxylase major
DF184_RS03985	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DF184_RS04025	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DF184_RS04035	COG1131	(ABC) transporter
DF184_RS04040	COG2188	Transcriptional regulator
DF184_RS04050	COG0205	6-phosphofructokinase activity
DF184_RS04055	COG0469	pyruvate kinase activity
DF184_RS04085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DF184_RS04090	COG2755	lipolytic protein G-D-S-L family
DF184_RS04090	COG0657	acetylesterase activity
DF184_RS04100	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DF184_RS04105	COG0765	amino acid transport
DF184_RS04110	COG1126	abc transporter atp-binding protein
DF184_RS04115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DF184_RS04120	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DF184_RS04140	COG1846	Transcriptional regulator
DF184_RS04145	COG3759	membrane
DF184_RS04170	COG2195	Cleaves the N-terminal amino acid of tripeptides
DF184_RS04175	COG0561	phosphatase activity
DF184_RS04210	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DF184_RS04215	COG0196	riboflavin kinase activity
DF184_RS04220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DF184_RS04225	COG1393	Belongs to the ArsC family
DF184_RS04230	COG4476	Belongs to the UPF0223 family
DF184_RS04235	COG0483	inositol monophosphate 1-phosphatase activity
DF184_RS04240	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
DF184_RS04240	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DF184_RS04250	COG0573	inorganic phosphate transmembrane transporter activity
DF184_RS04255	COG0581	inorganic phosphate transmembrane transporter activity
DF184_RS04260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DF184_RS04265	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DF184_RS04270	COG0704	Plays a role in the regulation of phosphate uptake
DF184_RS04280	COG0745	RESPONSE REGULATOR receiver
DF184_RS04285	COG5002	protein histidine kinase activity
DF184_RS04300	COG1072	(Pantothenic acid kinase))
DF184_RS04305	COG2813	Specifically methylates the guanine in position
DF184_RS04310	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DF184_RS04320	COG0295	cytidine deaminase activity
DF184_RS04325	COG1744	ABC transporter substrate-binding protein PnrA-like
DF184_RS04330	COG3845	ABC transporter
DF184_RS04335	COG4603	Belongs to the binding-protein-dependent transport system permease family
DF184_RS04340	COG1079	Belongs to the binding-protein-dependent transport system permease family
DF184_RS04345	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DF184_RS04350	COG0039	L-malate dehydrogenase activity
DF184_RS04355	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DF184_RS04360	COG3764	Sortase (surface protein transpeptidase)
DF184_RS04370	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DF184_RS04375	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DF184_RS04390	COG1104	cysteine desulfurase activity
DF184_RS04400	COG4116	CYTH
DF184_RS04405	COG2357	RelA SpoT domain protein
DF184_RS04410	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DF184_RS04415	COG0564	pseudouridine synthase activity
DF184_RS04420	COG0280	phosphate acetyltransferase
DF184_RS04425	COG1132	(ABC) transporter
DF184_RS04430	COG1132	(ABC) transporter
DF184_RS04440	COG1194	a g-specific adenine glycosylase
DF184_RS04445	COG1396	sequence-specific DNA binding
DF184_RS04465	COG2873	o-acetylhomoserine
DF184_RS04470	COG0488	(ABC) transporter
DF184_RS04475	COG0456	acetyltransferase
DF184_RS04480	COG1126	abc transporter atp-binding protein
DF184_RS04495	COG3583	domain protein
DF184_RS04510	COG4978	Transcriptional regulator
DF184_RS04510	COG0789	Transcriptional regulator
DF184_RS04530	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
DF184_RS04535	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
DF184_RS04540	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DF184_RS04545	COG1882	Formate acetyltransferase
DF184_RS04550	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DF184_RS04580	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
DF184_RS04585	COG4766	ethanolamine catabolic process
DF184_RS04595	COG1012	belongs to the aldehyde dehydrogenase family
DF184_RS04595	COG1454	alcohol dehydrogenase
DF184_RS04600	COG4869	propanediol catabolic process
DF184_RS04625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DF184_RS04630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DF184_RS04640	COG0297	glycogen (starch) synthase activity
DF184_RS04665	COG0167	dihydroorotate dehydrogenase activity
DF184_RS04670	COG0284	orotidine-5'-phosphate decarboxylase activity
DF184_RS04675	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DF184_RS04685	COG0463	Glycosyl transferase, family 2
DF184_RS04690	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DF184_RS04700	COG0737	Belongs to the 5'-nucleotidase family
DF184_RS04715	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DF184_RS04720	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DF184_RS04730	COG1272	protein, Hemolysin III
DF184_RS04740	COG0446	pyridine nucleotide-disulphide oxidoreductase
DF184_RS04745	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DF184_RS04750	COG1937	Protein conserved in bacteria
DF184_RS04755	COG0110	maltose O-acetyltransferase activity
DF184_RS04760	COG0758	DNA mediated transformation
DF184_RS04765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DF184_RS04770	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DF184_RS04775	COG0222	ribosome binding
DF184_RS04975	COG0500	methyltransferase
DF184_RS04985	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DF184_RS05060	COG1475	DNA binding
DF184_RS05065	COG4443	Transcriptional Coactivator p15 (PC4)
DF184_RS05135	COG1396	sequence-specific DNA binding
DF184_RS05140	COG0542	response to heat
DF184_RS05145	COG0613	PHP domain protein
DF184_RS05165	COG3843	relaxase mobilization nuclease domain protein
DF184_RS05170	COG2205	protein histidine kinase activity
DF184_RS05175	COG0745	RESPONSE REGULATOR receiver
DF184_RS05220	COG1396	sequence-specific DNA binding
DF184_RS05230	COG4974	Belongs to the 'phage' integrase family
DF184_RS05235	COG0647	UMP catabolic process
DF184_RS05240	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DF184_RS05280	COG1136	(ABC) transporter
DF184_RS05285	COG0577	efflux transmembrane transporter activity
DF184_RS05300	COG0745	RESPONSE REGULATOR receiver
DF184_RS05315	COG4974	Belongs to the 'phage' integrase family
DF184_RS05335	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DF184_RS05340	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DF184_RS05345	COG2188	Transcriptional regulator
DF184_RS05365	COG4268	DNA restriction-modification system
DF184_RS05370	COG1401	restriction endodeoxyribonuclease activity
DF184_RS05395	COG4221	oxidoreductase activity
DF184_RS05400	COG0741	lytic transglycosylase activity
DF184_RS05410	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DF184_RS05420	COG0009	L-threonylcarbamoyladenylate synthase
DF184_RS05425	COG2890	protein-(glutamine-N5) methyltransferase activity
DF184_RS05430	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DF184_RS05455	COG0481	GTPase activity
DF184_RS05475	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DF184_RS05485	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DF184_RS05490	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DF184_RS05505	COG1940	carbohydrate kinase activity
DF184_RS05515	COG0488	(ABC) transporter
DF184_RS05520	COG0617	tRNA 3'-terminal CCA addition
DF184_RS05525	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DF184_RS05530	COG1307	EDD domain protein, DegV family
DF184_RS05540	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DF184_RS05540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DF184_RS05540	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DF184_RS05545	COG1105	Belongs to the carbohydrate kinase PfkB family
DF184_RS05550	COG1349	DNA-binding transcription factor activity
DF184_RS05555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DF184_RS05560	COG0336	Belongs to the RNA methyltransferase TrmD family
DF184_RS05565	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DF184_RS05570	COG0534	Mate efflux family protein
DF184_RS05580	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DF184_RS05585	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DF184_RS05600	COG1177	transmembrane transport
DF184_RS05605	COG1176	ABC-type spermidine putrescine transport system, permease component I
DF184_RS05615	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DF184_RS05620	COG0083	homoserine kinase activity
DF184_RS05625	COG0460	homoserine dehydrogenase
DF184_RS05630	COG0726	polysaccharide deacetylase
DF184_RS05635	COG1132	(ABC) transporter
DF184_RS05650	COG0228	four-way junction DNA binding
DF184_RS05660	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DF184_RS05665	COG2521	methyltransferase
DF184_RS05665	COG2136	Putative SAM-dependent methyltransferase
DF184_RS05680	COG0505	Belongs to the CarA family
DF184_RS05685	COG0540	Belongs to the ATCase OTCase family
DF184_RS05690	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DF184_RS05700	COG2824	Alkylphosphonate utilization operon protein PhnA
DF184_RS05705	COG0564	pseudouridine synthase activity
DF184_RS05720	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DF184_RS05725	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DF184_RS05735	COG1114	Component of the transport system for branched-chain amino acids
DF184_RS05740	COG0301	tRNA thio-modification
DF184_RS05745	COG1104	cysteine desulfurase activity
DF184_RS05770	COG0539	negative regulation of cytoplasmic translation
DF184_RS05790	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DF184_RS05800	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DF184_RS05820	COG2184	nucleotidyltransferase activity
DF184_RS05830	COG0187	DNA topoisomerase II activity
DF184_RS05845	COG1074	ATP-dependent DNA helicase activity
DF184_RS05850	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DF184_RS05885	COG1131	(ABC) transporter
DF184_RS05925	COG1011	Hydrolase
DF184_RS05935	COG0210	DNA helicase
DF184_RS05950	COG1164	Oligoendopeptidase f
DF184_RS05965	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DF184_RS05970	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DF184_RS05975	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DF184_RS05985	COG0446	pyridine nucleotide-disulphide oxidoreductase
DF184_RS05990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DF184_RS05995	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DF184_RS06015	COG1882	Formate acetyltransferase
DF184_RS06020	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DF184_RS06025	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DF184_RS06030	COG1447	Phosphotransferase system cellobiose-specific component IIA
DF184_RS06040	COG1349	DNA-binding transcription factor activity
DF184_RS06045	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DF184_RS06075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DF184_RS06085	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DF184_RS06095	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DF184_RS06100	COG4684	Psort location CytoplasmicMembrane, score
DF184_RS06105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DF184_RS06120	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DF184_RS06130	COG0077	Prephenate dehydratase
DF184_RS06135	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DF184_RS06145	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DF184_RS06150	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DF184_RS06155	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DF184_RS06160	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DF184_RS06170	COG1116	anion transmembrane transporter activity
DF184_RS06170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DF184_RS06175	COG4120	Belongs to the binding-protein-dependent transport system permease family
DF184_RS06195	COG3684	Belongs to the aldolase LacD family
DF184_RS06205	COG3679	Belongs to the UPF0342 family
DF184_RS06210	COG0287	Prephenate dehydrogenase
DF184_RS06215	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DF184_RS06220	COG0710	3-dehydroquinate dehydratase activity
DF184_RS06225	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DF184_RS06230	COG1368	sulfuric ester hydrolase activity
DF184_RS06245	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DF184_RS06255	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DF184_RS06285	COG1216	Glycosyl transferase, family 2
DF184_RS06300	COG1442	glycosyl transferase family 8
DF184_RS06300	COG1216	Glycosyl transferase, family 2
DF184_RS06305	COG1442	glycosyl transferase family 8
DF184_RS06335	COG1216	Glycosyl transferase, family 2
DF184_RS06335	COG1442	glycosyl transferase family 8
DF184_RS06365	COG1091	dTDP-4-dehydrorhamnose reductase activity
DF184_RS06370	COG1088	dTDP-glucose 4,6-dehydratase activity
DF184_RS06385	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DF184_RS06395	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DF184_RS06400	COG2384	SAM-dependent methyltransferase
DF184_RS06415	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DF184_RS06425	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DF184_RS06425	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DF184_RS06430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DF184_RS06440	COG0300	oxidoreductase activity
DF184_RS06445	COG1234	tRNA 3'-trailer cleavage
DF184_RS06455	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DF184_RS06460	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DF184_RS06470	COG2807	transmembrane transport
DF184_RS06475	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DF184_RS06480	COG2610	gluconate transmembrane transporter activity
DF184_RS06500	COG0302	gtp cyclohydrolase
DF184_RS06505	COG1051	belongs to the nudix hydrolase family
DF184_RS06530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DF184_RS06530	COG0072	phenylalanine-tRNA ligase activity
DF184_RS06560	COG1028	Short-chain dehydrogenase reductase Sdr
DF184_RS06565	COG1312	Catalyzes the dehydration of D-mannonate
DF184_RS06575	COG0800	Aldolase
DF184_RS06585	COG3250	beta-galactosidase activity
DF184_RS06595	COG2211	Major facilitator Superfamily
DF184_RS06610	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DF184_RS06620	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DF184_RS06625	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DF184_RS06630	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DF184_RS06635	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DF184_RS06640	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DF184_RS06645	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DF184_RS06650	COG0356	it plays a direct role in the translocation of protons across the membrane
DF184_RS06660	COG1597	lipid kinase activity
DF184_RS06670	COG0701	Predicted permease
DF184_RS06675	COG3689	TIGRFAM TIGR03943 family protein
DF184_RS06680	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DF184_RS06695	COG0552	protein localization to endoplasmic reticulum
DF184_RS06700	COG0561	phosphatase activity
DF184_RS06705	COG0561	phosphatase activity
DF184_RS06710	COG1196	nuclear chromosome segregation
DF184_RS06745	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DF184_RS06750	COG0538	isocitrate dehydrogenase activity
DF184_RS06755	COG0372	Belongs to the citrate synthase family
DF184_RS06760	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DF184_RS06765	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DF184_RS06770	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DF184_RS06775	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DF184_RS06810	COG1476	TRANSCRIPTIONal
DF184_RS06825	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DF184_RS06835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DF184_RS06840	COG4122	O-methyltransferase activity
DF184_RS06875	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DF184_RS06875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DF184_RS06890	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DF184_RS06895	COG1061	Type III restriction enzyme res subunit
DF184_RS06900	COG1002	Type II restriction enzyme, methylase subunits
DF184_RS06925	COG0531	amino acid
DF184_RS06935	COG0708	Exodeoxyribonuclease III
DF184_RS06945	COG1393	Belongs to the ArsC family
DF184_RS06950	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DF184_RS06955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DF184_RS06965	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DF184_RS06975	COG4467	Involved in initiation control of chromosome replication
DF184_RS06980	COG0470	DNA polymerase III
DF184_RS06985	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DF184_RS06990	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DF184_RS07005	COG0517	IMP dehydrogenase activity
DF184_RS07035	COG0683	leucine binding
DF184_RS07050	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DF184_RS07055	COG0366	Alpha amylase catalytic
DF184_RS07065	COG0395	ABC-type sugar transport system, permease component
DF184_RS07070	COG1175	transmembrane transport
DF184_RS07075	COG1653	transport
DF184_RS07085	COG2207	Transcriptional regulator
DF184_RS07090	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DF184_RS07095	COG0626	cystathionine gamma-synthase activity
DF184_RS07115	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DF184_RS07120	COG2827	Endonuclease containing a URI domain
DF184_RS07140	COG0640	Transcriptional regulator
DF184_RS07145	COG0513	Belongs to the DEAD box helicase family
DF184_RS07155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DF184_RS07180	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DF184_RS07190	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DF184_RS07215	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DF184_RS07220	COG0768	penicillin binding
DF184_RS07225	COG0488	(ABC) transporter
DF184_RS07230	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DF184_RS07240	COG0745	RESPONSE REGULATOR receiver
DF184_RS07250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DF184_RS07255	COG0765	amino acid transport
DF184_RS07260	COG0765	amino acid transport
DF184_RS07280	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DF184_RS07295	COG0438	transferase activity, transferring glycosyl groups
DF184_RS07310	COG5002	protein histidine kinase activity
DF184_RS07320	COG1609	Transcriptional regulator
DF184_RS07350	COG0343	queuine tRNA-ribosyltransferase activity
DF184_RS07365	COG1832	CoA-binding protein
DF184_RS07375	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DF184_RS07375	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DF184_RS07395	COG1136	(ABC) transporter
DF184_RS07410	COG1131	(ABC) transporter
DF184_RS07420	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DF184_RS07425	COG0583	DNA-binding transcription factor activity
DF184_RS07435	COG0110	maltose O-acetyltransferase activity
DF184_RS07440	COG2217	Heavy metal translocating P-type atpase
DF184_RS07455	COG1063	alcohol dehydrogenase
DF184_RS07475	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DF184_RS07480	COG0557	exoribonuclease II activity
DF184_RS07490	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DF184_RS07495	COG2814	Major facilitator Superfamily
DF184_RS07505	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DF184_RS07510	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DF184_RS07515	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DF184_RS07525	COG1737	Transcriptional regulator
DF184_RS07545	COG1011	Hydrolase
DF184_RS07550	COG1132	(ABC) transporter
DF184_RS07555	COG1132	(ABC) transporter
DF184_RS07585	COG2177	Part of the ABC transporter FtsEX involved in
DF184_RS07590	COG2884	Cell division ATP-binding protein ftsE
DF184_RS07600	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DF184_RS07640	COG1078	dGTPase activity
DF184_RS07650	COG0149	triose-phosphate isomerase activity
DF184_RS07655	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DF184_RS07670	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DF184_RS07675	COG0772	Belongs to the SEDS family
DF184_RS07695	COG3859	Proton-coupled thiamine transporter YuaJ
DF184_RS07705	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DF184_RS07715	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DF184_RS07730	COG0577	efflux transmembrane transporter activity
DF184_RS07735	COG1136	(ABC) transporter
DF184_RS07740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DF184_RS07745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DF184_RS07750	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DF184_RS07755	COG1268	BioY protein
DF184_RS07760	COG4443	Transcriptional Coactivator p15 (PC4)
DF184_RS07770	COG0826	peptidase U32
DF184_RS07785	COG0789	Transcriptional regulator
DF184_RS07795	COG1227	inorganic diphosphatase activity
DF184_RS07810	COG1733	regulation of RNA biosynthetic process
DF184_RS07815	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DF184_RS07820	COG2514	catechol 2,3-dioxygenase activity
DF184_RS07825	COG1472	Belongs to the glycosyl hydrolase 3 family
DF184_RS07830	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DF184_RS07835	COG1253	flavin adenine dinucleotide binding
DF184_RS07840	COG1119	ATPase activity
DF184_RS07845	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DF184_RS07865	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DF184_RS07870	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DF184_RS07875	COG0133	tryptophan synthase activity
DF184_RS07890	COG4470	Protein conserved in bacteria
DF184_RS07895	COG3480	Lon protease (S16) C-terminal proteolytic domain
DF184_RS07900	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DF184_RS07905	COG0742	ribosomal rna small subunit methyltransferase
DF184_RS07915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DF184_RS07920	COG4483	Protein conserved in bacteria
DF184_RS07925	COG2197	response regulator
DF184_RS07930	COG4585	Histidine kinase
DF184_RS07935	COG0842	Transport permease protein
DF184_RS07940	COG1131	(ABC) transporter
DF184_RS07955	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DF184_RS07965	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DF184_RS07965	COG2755	lipolytic protein G-D-S-L family
DF184_RS07970	COG0671	phosphoesterase, PA-phosphatase related
DF184_RS07975	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DF184_RS07990	COG0747	negative chemotaxis
DF184_RS07995	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DF184_RS08000	COG1187	pseudouridine synthase activity
DF184_RS08005	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DF184_RS08010	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DF184_RS08015	COG0582	viral genome integration into host DNA
DF184_RS08035	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DF184_RS08040	COG3763	UPF0154 protein
DF184_RS08050	COG3579	cysteine-type endopeptidase activity
DF184_RS08065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DF184_RS08070	COG1254	Belongs to the acylphosphatase family
DF184_RS08080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DF184_RS08085	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DF184_RS08095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DF184_RS08105	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DF184_RS08120	COG1160	GTP binding
DF184_RS08135	COG1484	DNA-dependent DNA replication
DF184_RS08145	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DF184_RS08150	COG0628	permease
DF184_RS08155	COG0745	RESPONSE REGULATOR receiver
DF184_RS08160	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DF184_RS08170	COG0492	ferredoxin-NADP+ reductase activity
DF184_RS08180	COG0513	Belongs to the DEAD box helicase family
DF184_RS08185	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DF184_RS08190	COG0768	penicillin binding
DF184_RS08200	COG0275	rRNA processing
DF184_RS08245	COG4939	FMN-binding domain protein
DF184_RS08250	COG0142	geranyltranstransferase activity
DF184_RS08255	COG1252	NADH dehydrogenase
DF184_RS08270	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DF184_RS08275	COG0569	domain protein
DF184_RS08280	COG0534	Mate efflux family protein
DF184_RS08290	COG4224	UPF0291 protein
DF184_RS08295	COG0751	glycine-tRNA ligase activity
DF184_RS08320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DF184_RS08325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DF184_RS08330	COG1464	Belongs to the NlpA lipoprotein family
DF184_RS08335	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DF184_RS08340	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DF184_RS08345	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DF184_RS08350	COG2252	PERMEase
DF184_RS08355	COG0561	phosphatase activity
DF184_RS08365	COG3715	PTS system
DF184_RS08370	COG3716	PTS system mannose fructose sorbose family IID component
DF184_RS08400	COG0439	Biotin carboxylase
DF184_RS08420	COG1028	Short-chain dehydrogenase reductase Sdr
DF184_RS08425	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DF184_RS08430	COG2070	2-Nitropropane dioxygenase
DF184_RS08440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DF184_RS08450	COG1024	Enoyl-CoA hydratase
DF184_RS08455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DF184_RS08460	COG0527	aspartate kinase activity
DF184_RS08465	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DF184_RS08470	COG0736	holo-[acyl-carrier-protein] synthase activity
DF184_RS08475	COG0653	protein targeting
DF184_RS08480	COG3583	domain protein
DF184_RS08480	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
DF184_RS08485	COG1940	carbohydrate kinase activity
DF184_RS08490	COG2190	(PTS) system
DF184_RS08490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DF184_RS08490	COG1263	PTS System
DF184_RS08495	COG1621	beta-fructofuranosidase activity
DF184_RS08500	COG1609	Transcriptional regulator
DF184_RS08505	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DF184_RS08520	COG0006	proline dipeptidase activity
DF184_RS08540	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DF184_RS08560	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DF184_RS08565	COG0629	single-stranded DNA binding
DF184_RS08575	COG0095	Lipoate-protein ligase
DF184_RS08580	COG2723	6-phospho-beta-galactosidase activity
DF184_RS08595	COG2723	6-phospho-beta-galactosidase activity
DF184_RS08600	COG0346	lactoylglutathione lyase activity
DF184_RS08605	COG2723	6-phospho-beta-galactosidase activity
DF184_RS08610	COG2207	Transcriptional regulator
DF184_RS08610	COG1917	Cupin 2, conserved barrel domain protein
DF184_RS08620	COG2272	Belongs to the type-B carboxylesterase lipase family
DF184_RS08625	COG2190	(PTS) system
DF184_RS08625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DF184_RS08625	COG1263	PTS System
DF184_RS08630	COG3711	transcriptional antiterminator
DF184_RS08645	COG0508	dehydrogenase complex catalyzes the overall conversion of
DF184_RS08650	COG0508	dehydrogenase complex catalyzes the overall conversion of
DF184_RS08650	COG0022	dehydrogenase e1 component
DF184_RS08655	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DF184_RS08660	COG2860	membrane
DF184_RS08685	COG1396	sequence-specific DNA binding
DF184_RS08710	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DF184_RS08715	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DF184_RS08725	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DF184_RS08730	COG0195	Participates in both transcription termination and antitermination
DF184_RS08740	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DF184_RS08750	COG4473	ABC transporter
DF184_RS08755	COG1131	(ABC) transporter
DF184_RS08760	COG0537	adenosine 5'-monophosphoramidase activity
DF184_RS08770	COG1316	TRANSCRIPTIONal
DF184_RS08780	COG0802	atpase or kinase
DF184_RS08785	COG1461	Dihydroxyacetone kinase
DF184_RS08795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DF184_RS08800	COG0601	transmembrane transport
DF184_RS08805	COG4608	Belongs to the ABC transporter superfamily
DF184_RS08825	COG1686	Belongs to the peptidase S11 family
DF184_RS08840	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DF184_RS08845	COG0719	Fe-S assembly protein
DF184_RS08855	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DF184_RS08860	COG4862	establishment of competence for transformation
DF184_RS08865	COG1968	undecaprenyl-diphosphatase activity
DF184_RS08870	COG0765	amino acid transport
DF184_RS08890	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DF184_RS08895	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DF184_RS08900	COG0440	acetolactate synthase activity
DF184_RS08905	COG0028	Belongs to the TPP enzyme family
DF184_RS08910	COG0463	Glycosyl transferase, family 2
DF184_RS08925	COG0129	dihydroxy-acid dehydratase activity
DF184_RS08935	COG2151	metal-sulfur cluster biosynthetic enzyme
DF184_RS08995	COG1216	Glycosyl transferase, family 2
DF184_RS08995	COG1442	glycosyl transferase family 8
DF184_RS09010	COG1216	Glycosyl transferase, family 2
DF184_RS09010	COG1442	glycosyl transferase family 8
DF184_RS09020	COG1442	glycosyl transferase family 8
DF184_RS09095	COG0582	viral genome integration into host DNA
DF184_RS09105	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DF184_RS09130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DF184_RS09145	COG3842	ATPase activity
DF184_RS09155	COG4753	response regulator
DF184_RS09155	COG2207	Transcriptional regulator
DF184_RS09160	COG2972	Histidine kinase
DF184_RS09175	COG1653	transport
DF184_RS09180	COG0395	ABC-type sugar transport system, permease component
DF184_RS09185	COG1175	transmembrane transport
DF184_RS09200	COG0383	alpha-mannosidase activity
DF184_RS09225	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DF184_RS09245	COG1045	serine acetyltransferase
DF184_RS09250	COG1185	polyribonucleotide nucleotidyltransferase activity
DF184_RS09270	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DF184_RS09300	COG0464	growth
DF184_RS09315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DF184_RS09320	COG1187	pseudouridine synthase activity
DF184_RS09335	COG3547	Transposase (IS116 IS110 IS902 family)
DF184_RS09345	COG0242	peptide deformylase activity
DF184_RS09365	COG1136	(ABC) transporter
DF184_RS09390	COG0066	3-isopropylmalate dehydratase activity
DF184_RS09400	COG0473	3-isopropylmalate dehydrogenase activity
DF184_RS09415	COG2309	aminopeptidase activity
DF184_RS09425	COG2176	DNA-directed DNA polymerase activity
DF184_RS09445	COG2376	Dihydroxyacetone kinase
DF184_RS09455	COG2376	Dihydroxyacetone kinase
DF184_RS09460	COG1461	Dihydroxyacetone kinase
DF184_RS09465	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
DF184_RS09470	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DF184_RS09475	COG0442	prolyl-tRNA aminoacylation
DF184_RS09485	COG4589	Belongs to the CDS family
DF184_RS09490	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DF184_RS09495	COG1862	Preprotein translocase
DF184_RS09510	COG2918	glutathione biosynthetic process
DF184_RS09510	COG1181	Belongs to the D-alanine--D-alanine ligase family
DF184_RS09520	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DF184_RS09525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DF184_RS09530	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DF184_RS09535	COG0542	response to heat
DF184_RS09540	COG4463	regulation of RNA biosynthetic process
DF184_RS09555	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DF184_RS09690	COG0740	serine-type endopeptidase activity
DF184_RS09725	COG0582	viral genome integration into host DNA
DF184_RS09845	COG0582	viral genome integration into host DNA
DF184_RS09865	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DF184_RS09870	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DF184_RS09875	COG0492	ferredoxin-NADP+ reductase activity
DF184_RS09880	COG0564	pseudouridine synthase activity
DF184_RS09885	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DF184_RS09905	COG1564	THIamine pyrophosphokinase
DF184_RS09915	COG1162	GTPase activity
DF184_RS09925	COG1132	(ABC) transporter
DF184_RS09950	COG4115	mRNA cleavage
DF184_RS09975	COG0084	hydrolase, TatD family'
DF184_RS09985	COG1847	R3H domain protein
DF184_RS09995	COG0594	ribonuclease P activity
DF184_RS10000	COG0165	Argininosuccinate lyase
DF184_RS10005	COG0137	argininosuccinate synthase activity
DF184_RS10015	COG1827	regulation of RNA biosynthetic process
DF184_RS10030	COG2040	homocysteine
DF184_RS10035	COG0833	amino acid
DF184_RS10065	COG1442	glycosyl transferase family 8
DF184_RS10090	COG0756	dUTP diphosphatase activity
DF184_RS10120	COG0577	efflux transmembrane transporter activity
DF184_RS10120	COG1136	(ABC) transporter
DF184_RS10125	COG1132	(ABC) transporter
DF184_RS10130	COG1132	(ABC) transporter
DF184_RS10140	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DF184_RS10145	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DF184_RS10150	COG0705	Rhomboid family
DF184_RS10155	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DF184_RS10160	COG1473	amidohydrolase
DF184_RS10165	COG2171	N-acyltransferase activity
DF184_RS10175	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DF184_RS10190	COG1442	glycosyl transferase family 8
DF184_RS10210	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DF184_RS10235	COG3623	hexulose-6-phosphate isomerase
DF184_RS10260	COG1523	belongs to the glycosyl hydrolase 13 family
DF184_RS10265	COG1609	Transcriptional regulator
DF184_RS10270	COG1126	abc transporter atp-binding protein
DF184_RS10275	COG0765	amino acid transport
DF184_RS10280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DF184_RS10290	COG3942	CHAP domain
DF184_RS10300	COG3590	peptidase
DF184_RS10305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DF184_RS10310	COG1321	iron dependent repressor
DF184_RS10310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DF184_RS10315	COG1121	(ABC) transporter
DF184_RS10330	COG0803	Belongs to the bacterial solute-binding protein 9 family
DF184_RS10350	COG1490	D-aminoacyl-tRNA deacylase activity
DF184_RS10360	COG0737	Belongs to the 5'-nucleotidase family
DF184_RS10370	COG1811	Na channel or pump
DF184_RS10375	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DF184_RS10400	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DF184_RS10430	COG0737	Belongs to the 5'-nucleotidase family
DF184_RS10440	COG1328	CTP reductase activity
DF184_RS10445	COG1126	abc transporter atp-binding protein
DF184_RS10455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DF184_RS10460	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DF184_RS10485	COG1438	arginine binding
DF184_RS10490	COG0018	arginyl-trna synthetase
DF184_RS10510	COG1640	4-alpha-glucanotransferase
DF184_RS10515	COG2182	Extracellular solute-binding protein
DF184_RS10520	COG1175	transmembrane transport
DF184_RS10525	COG3833	ABC-type maltose transport systems, permease component
DF184_RS10530	COG5521	maltodextrose utilization protein MalA
DF184_RS10535	COG1609	Transcriptional regulator
DF184_RS10540	COG1523	belongs to the glycosyl hydrolase 13 family
DF184_RS10545	COG1780	Probably involved in ribonucleotide reductase function
DF184_RS10550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DF184_RS10555	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DF184_RS10560	COG2153	protein acetylation
DF184_RS10565	COG4989	oxidoreductase activity
DF184_RS10570	COG1216	Glycosyl transferase, family 2
DF184_RS10575	COG1472	Belongs to the glycosyl hydrolase 3 family
DF184_RS10620	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DF184_RS10635	COG0305	Participates in initiation and elongation during chromosome replication
DF184_RS10640	COG0359	binds to the 23S rRNA
DF184_RS10650	COG0445	tRNA wobble uridine modification
DF184_RS10655	COG0494	nUDIX hydrolase
DF184_RS10670	COG1733	regulation of RNA biosynthetic process
DF184_RS10680	COG0482	sulfurtransferase activity
DF184_RS10685	COG1760	l-serine dehydratase
DF184_RS10690	COG1760	l-serine dehydratase
DF184_RS10700	COG0745	RESPONSE REGULATOR receiver
DF184_RS10705	COG3850	Histidine kinase
DF184_RS10705	COG5002	protein histidine kinase activity
DF184_RS10715	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DF184_RS10720	COG1122	ATPase activity
DF184_RS10725	COG1122	ATPase activity
DF184_RS10730	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DF184_RS10735	COG1426	Protein conserved in bacteria
DF184_RS10740	COG0612	Peptidase, M16
DF184_RS10745	COG0612	Peptidase, M16
DF184_RS10755	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DF184_RS10760	COG0516	GMP reductase activity
DF184_RS10760	COG0517	IMP dehydrogenase activity
DF184_RS10770	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DF184_RS10775	COG0488	(ABC) transporter
DF184_RS10810	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DF184_RS10815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DF184_RS10820	COG1475	DNA binding
DF184_RS10855	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DF184_RS10875	COG3290	protein histidine kinase activity
DF184_RS10895	COG2274	protein secretion by the type I secretion system
DF184_RS10900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family