locus-tag	class	description
CWM22_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CWM22_RS00010	COG0592	DNA-directed DNA polymerase activity
CWM22_RS00030	COG0012	GTP binding
CWM22_RS00035	COG0193	aminoacyl-tRNA hydrolase activity
CWM22_RS00040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CWM22_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CWM22_RS00065	COG0037	tRNA processing
CWM22_RS00075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CWM22_RS00205	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CWM22_RS00215	COG0436	Aminotransferase
CWM22_RS00220	COG1381	Involved in DNA repair and RecF pathway recombination
CWM22_RS00225	COG0416	fatty acid biosynthetic process
CWM22_RS00230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CWM22_RS00240	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CWM22_RS00255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CWM22_RS00265	COG0138	bifunctional purine biosynthesis protein purh
CWM22_RS00280	COG3583	domain protein
CWM22_RS00315	COG4372	Transposase
CWM22_RS00325	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CWM22_RS00340	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CWM22_RS00360	COG1131	(ABC) transporter
CWM22_RS00370	COG1132	(ABC) transporter
CWM22_RS00375	COG0789	Transcriptional regulator
CWM22_RS00380	COG2255	four-way junction helicase activity
CWM22_RS00385	COG0546	phosphoglycolate phosphatase activity
CWM22_RS00410	COG0285	dihydrofolate synthase activity
CWM22_RS00425	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CWM22_RS00435	COG1266	CAAX protease self-immunity
CWM22_RS00440	COG0632	four-way junction helicase activity
CWM22_RS00445	COG0519	Catalyzes the synthesis of GMP from XMP
CWM22_RS00460	COG1393	Belongs to the ArsC family
CWM22_RS00465	COG4472	Bacterial protein of unknown function (DUF965)
CWM22_RS00470	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CWM22_RS00475	COG3906	Belongs to the UPF0473 family
CWM22_RS00490	COG0051	transcription antitermination factor activity, RNA binding
CWM22_RS00495	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CWM22_RS00500	COG0088	Forms part of the polypeptide exit tunnel
CWM22_RS00505	COG0089	rRNA binding
CWM22_RS00510	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CWM22_RS00515	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CWM22_RS00520	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CWM22_RS00525	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CWM22_RS00530	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CWM22_RS00535	COG0255	Belongs to the universal ribosomal protein uL29 family
CWM22_RS00540	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CWM22_RS00545	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CWM22_RS00550	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CWM22_RS00555	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CWM22_RS00560	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CWM22_RS00565	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CWM22_RS00570	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CWM22_RS00575	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CWM22_RS00580	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CWM22_RS00585	COG1841	ribosomal large subunit assembly
CWM22_RS00595	COG0201	protein transport
CWM22_RS00600	COG0563	adenylate kinase activity
CWM22_RS00605	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CWM22_RS00610	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CWM22_RS00615	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CWM22_RS00625	COG0202	RNA polymerase activity
CWM22_RS00775	COG4372	Transposase
CWM22_RS00815	COG1121	(ABC) transporter
CWM22_RS00820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CWM22_RS00825	COG3443	Belongs to the bacterial solute-binding protein 9 family
CWM22_RS00825	COG0803	Belongs to the bacterial solute-binding protein 9 family
CWM22_RS00860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CWM22_RS00870	COG0085	RNA polymerase activity
CWM22_RS00875	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CWM22_RS00885	COG1619	proteins homologs of microcin C7 resistance protein MccF
CWM22_RS00890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CWM22_RS00895	COG1459	type II secretion system
CWM22_RS00900	COG4537	Required for transformation and DNA binding
CWM22_RS00930	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CWM22_RS00940	COG0285	dihydrofolate synthase activity
CWM22_RS00960	COG1363	Peptidase, m42
CWM22_RS00970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CWM22_RS00980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CWM22_RS01005	COG0459	protein refolding
CWM22_RS01020	COG0049	tRNA binding
CWM22_RS01025	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CWM22_RS01045	COG0126	phosphoglycerate kinase activity
CWM22_RS01060	COG0789	Transcriptional regulator
CWM22_RS01065	COG0174	glutamine synthetase
CWM22_RS01080	COG1396	sequence-specific DNA binding
CWM22_RS01100	COG1214	PFAM Peptidase M22, glycoprotease
CWM22_RS01110	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CWM22_RS01145	COG2855	membrane
CWM22_RS01155	COG1131	(ABC) transporter
CWM22_RS01165	COG2081	HI0933 family
CWM22_RS01185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWM22_RS01200	COG3959	Transketolase, thiamine diphosphate binding domain
CWM22_RS01205	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CWM22_RS01215	COG0584	glycerophosphoryl diester phosphodiesterase
CWM22_RS01220	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CWM22_RS01230	COG2222	sugar isomerase
CWM22_RS01255	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CWM22_RS01265	COG1882	Formate acetyltransferase
CWM22_RS01270	COG0366	Alpha amylase catalytic
CWM22_RS01270	COG0366	Alpha amylase catalytic
CWM22_RS01290	COG2910	NAD(P)H-binding
CWM22_RS01350	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CWM22_RS01355	COG0681	Belongs to the peptidase S26 family
CWM22_RS01385	COG0366	Alpha amylase catalytic
CWM22_RS01400	COG1263	PTS System
CWM22_RS01400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWM22_RS01405	COG2188	Transcriptional regulator
CWM22_RS01430	COG1193	negative regulation of DNA recombination
CWM22_RS01445	COG0656	L-ascorbic acid biosynthetic process
CWM22_RS01450	COG3118	belongs to the thioredoxin family
CWM22_RS01470	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CWM22_RS01470	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CWM22_RS01480	COG1136	(ABC) transporter
CWM22_RS01485	COG1115	amino acid carrier protein
CWM22_RS01490	COG0668	transmembrane transport
CWM22_RS01505	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CWM22_RS01510	COG0167	dihydroorotate dehydrogenase activity
CWM22_RS01520	COG0561	phosphatase activity
CWM22_RS01540	COG1131	(ABC) transporter
CWM22_RS01545	COG1309	transcriptional regulator
CWM22_RS01550	COG1511	domain protein
CWM22_RS01560	COG1668	transmembrane transport
CWM22_RS01585	COG1346	cytolysis
CWM22_RS01590	COG2116	formate transmembrane transporter activity
CWM22_RS01595	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CWM22_RS01605	COG0494	nUDIX hydrolase
CWM22_RS01610	COG1349	DNA-binding transcription factor activity
CWM22_RS01620	COG0698	ribose 5-phosphate isomerase
CWM22_RS01625	COG0698	ribose 5-phosphate isomerase
CWM22_RS01630	COG1105	Belongs to the carbohydrate kinase PfkB family
CWM22_RS01635	COG3684	Belongs to the aldolase LacD family
CWM22_RS01640	COG3711	transcriptional antiterminator
CWM22_RS01650	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CWM22_RS01650	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CWM22_RS01665	COG1408	metallophosphoesterase
CWM22_RS01710	COG1136	(ABC) transporter
CWM22_RS01710	COG0577	efflux transmembrane transporter activity
CWM22_RS01735	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CWM22_RS01740	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CWM22_RS01755	COG0124	histidyl-tRNA synthetase
CWM22_RS01760	COG1064	alcohol dehydrogenase
CWM22_RS01765	COG1454	alcohol dehydrogenase
CWM22_RS01765	COG1012	belongs to the aldehyde dehydrogenase family
CWM22_RS01775	COG4988	ABC transporter
CWM22_RS01795	COG1129	ABC transporter
CWM22_RS01800	COG0534	Mate efflux family protein
CWM22_RS01820	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CWM22_RS01835	COG1304	FMN binding
CWM22_RS01840	COG1132	(ABC) transporter
CWM22_RS01845	COG1132	(ABC) transporter
CWM22_RS01855	COG3830	Belongs to the UPF0237 family
CWM22_RS01860	COG2848	UPF0210 protein
CWM22_RS01865	COG0588	phosphoglycerate mutase activity
CWM22_RS01880	COG1420	regulation of RNA biosynthetic process
CWM22_RS01885	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CWM22_RS01890	COG0443	Heat shock 70 kDa protein
CWM22_RS01895	COG0484	heat shock protein binding
CWM22_RS01905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWM22_RS01910	COG0765	amino acid transport
CWM22_RS01925	COG3655	Transcriptional regulator
CWM22_RS01935	COG2217	Heavy metal translocating P-type atpase
CWM22_RS01950	COG0351	phosphomethylpyrimidine kinase
CWM22_RS01960	COG4475	Protein of unknown function (DUF436)
CWM22_RS01995	COG2910	NAD(P)H-binding
CWM22_RS02000	COG1959	2 iron, 2 sulfur cluster binding
CWM22_RS02030	COG0544	peptidyl-prolyl cis-trans isomerase activity
CWM22_RS02045	COG3343	RNA polymerase activity
CWM22_RS02050	COG0504	CTP synthase activity
CWM22_RS02060	COG0191	fructose-bisphosphate aldolase activity
CWM22_RS02065	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CWM22_RS02100	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CWM22_RS02125	COG0436	Aminotransferase
CWM22_RS02135	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CWM22_RS02140	COG1335	isochorismatase
CWM22_RS02145	COG0335	large ribosomal subunit rRNA binding
CWM22_RS02155	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CWM22_RS02160	COG0154	amidase activity
CWM22_RS02165	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CWM22_RS02200	COG1609	Transcriptional regulator
CWM22_RS02205	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CWM22_RS02210	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CWM22_RS02220	COG3142	Participates in the control of copper homeostasis
CWM22_RS02235	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CWM22_RS02240	COG1534	Rna-binding protein
CWM22_RS02245	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CWM22_RS02250	COG1713	HD superfamily hydrolase involved in NAD metabolism
CWM22_RS02260	COG1335	isochorismatase
CWM22_RS02265	COG0799	negative regulation of ribosome biogenesis
CWM22_RS02275	COG2226	methyltransferase
CWM22_RS02305	COG0789	Transcriptional regulator
CWM22_RS02310	COG2348	transferase activity, transferring amino-acyl groups
CWM22_RS02320	COG0242	peptide deformylase activity
CWM22_RS02330	COG1640	4-alpha-glucanotransferase
CWM22_RS02335	COG0058	SHG alpha-glucan phosphorylase activity
CWM22_RS02350	COG1263	PTS System
CWM22_RS02350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWM22_RS02350	COG2190	(PTS) system
CWM22_RS02355	COG0217	transcriptional regulatory protein
CWM22_RS02380	COG4720	Psort location CytoplasmicMembrane, score
CWM22_RS02390	COG1054	Belongs to the UPF0176 family
CWM22_RS02400	COG1122	ATPase activity
CWM22_RS02415	COG0357	Ribosomal RNA small subunit methyltransferase G
CWM22_RS02420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CWM22_RS02425	COG3331	DNA recombination
CWM22_RS02430	COG4474	Belongs to the UPF0398 family
CWM22_RS02435	COG3599	regulation of cell shape
CWM22_RS02445	COG0116	Belongs to the methyltransferase superfamily
CWM22_RS02460	COG1854	S-ribosylhomocysteine lyase activity
CWM22_RS02465	COG1418	mRNA catabolic process
CWM22_RS02475	COG1758	RNA polymerase activity
CWM22_RS02480	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CWM22_RS02485	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CWM22_RS02490	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CWM22_RS02490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CWM22_RS02495	COG0631	protein serine/threonine phosphatase activity
CWM22_RS02500	COG2815	serine threonine protein kinase
CWM22_RS02500	COG0515	serine threonine protein kinase
CWM22_RS02525	COG1098	S1 RNA binding domain
CWM22_RS02535	COG1739	Uncharacterized protein family UPF0029
CWM22_RS02540	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CWM22_RS02630	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CWM22_RS02640	COG3557	Belongs to the UPF0374 family
CWM22_RS02650	COG2188	Transcriptional regulator
CWM22_RS02655	COG2188	Transcriptional regulator
CWM22_RS02665	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWM22_RS02675	COG3716	PTS system mannose fructose sorbose family IID component
CWM22_RS02685	COG2017	converts alpha-aldose to the beta-anomer
CWM22_RS02700	COG0346	lactoylglutathione lyase activity
CWM22_RS02735	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CWM22_RS02770	COG1217	gtp-binding protein TYPA
CWM22_RS02790	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CWM22_RS02815	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CWM22_RS02820	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CWM22_RS02825	COG1799	cell septum assembly
CWM22_RS02840	COG3599	regulation of cell shape
CWM22_RS02860	COG0406	alpha-ribazole phosphatase activity
CWM22_RS02860	COG0494	nUDIX hydrolase
CWM22_RS02865	COG0542	response to heat
CWM22_RS02870	COG4703	Protein of unknown function (DUF1797)
CWM22_RS02875	COG0765	amino acid transport
CWM22_RS02885	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CWM22_RS02915	COG0745	RESPONSE REGULATOR receiver
CWM22_RS02920	COG5002	protein histidine kinase activity
CWM22_RS02930	COG1755	Isoprenylcysteine carboxyl methyltransferase
CWM22_RS02935	COG2321	neutral zinc metallopeptidase
CWM22_RS02940	COG1570	exodeoxyribonuclease VII activity
CWM22_RS02945	COG1722	exodeoxyribonuclease VII activity
CWM22_RS02955	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CWM22_RS02960	COG1438	arginine binding
CWM22_RS02965	COG0497	DNA recombination
CWM22_RS02970	COG1307	EDD domain protein, DegV family
CWM22_RS02975	COG2755	lipolytic protein G-D-S-L family
CWM22_RS02985	COG0776	regulation of translation
CWM22_RS03010	COG3425	synthase
CWM22_RS03030	COG0726	polysaccharide deacetylase
CWM22_RS03035	COG0513	Belongs to the DEAD box helicase family
CWM22_RS03040	COG0673	inositol 2-dehydrogenase activity
CWM22_RS03050	COG1695	Transcriptional regulator
CWM22_RS03065	COG1956	GAF domain-containing protein
CWM22_RS03070	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CWM22_RS03085	COG1363	Peptidase, m42
CWM22_RS03095	COG2131	deaminase
CWM22_RS03105	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CWM22_RS03110	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CWM22_RS03120	COG0024	Methionine aminopeptidase
CWM22_RS03130	COG2246	polysaccharide biosynthetic process
CWM22_RS03135	COG4708	membrane
CWM22_RS03140	COG0656	L-ascorbic acid biosynthetic process
CWM22_RS03145	COG2183	response to ionizing radiation
CWM22_RS03150	COG3091	SprT-like family
CWM22_RS03170	COG1482	cell wall glycoprotein biosynthetic process
CWM22_RS03175	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CWM22_RS03180	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CWM22_RS03200	COG0517	IMP dehydrogenase activity
CWM22_RS03200	COG1125	glycine betaine transport
CWM22_RS03205	COG1732	Glycine betaine
CWM22_RS03215	COG0436	Aminotransferase
CWM22_RS03230	COG2205	protein histidine kinase activity
CWM22_RS03235	COG1136	(ABC) transporter
CWM22_RS03240	COG0577	efflux transmembrane transporter activity
CWM22_RS03275	COG1028	Short-chain dehydrogenase reductase Sdr
CWM22_RS03295	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CWM22_RS03300	COG0494	nUDIX hydrolase
CWM22_RS03310	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CWM22_RS03325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CWM22_RS03350	COG4209	transmembrane transport
CWM22_RS03355	COG0395	ABC-type sugar transport system, permease component
CWM22_RS03360	COG1653	transport
CWM22_RS03365	COG1621	beta-fructofuranosidase activity
CWM22_RS03375	COG0346	lactoylglutathione lyase activity
CWM22_RS03415	COG2244	polysaccharide biosynthetic process
CWM22_RS03420	COG0528	UMP kinase activity
CWM22_RS03425	COG0233	cytoplasmic translational termination
CWM22_RS03430	COG2996	Protein conserved in bacteria
CWM22_RS03445	COG4479	Belongs to the UPF0346 family
CWM22_RS03450	COG3583	domain protein
CWM22_RS03455	COG3583	domain protein
CWM22_RS03475	COG1702	phosphate starvation-inducible protein PhoH
CWM22_RS03480	COG3590	peptidase
CWM22_RS03490	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CWM22_RS03490	COG1199	ATP-dependent helicase activity
CWM22_RS03495	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CWM22_RS03500	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CWM22_RS03505	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CWM22_RS03520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWM22_RS03525	COG3022	response to hydroperoxide
CWM22_RS03530	COG1316	TRANSCRIPTIONal
CWM22_RS03535	COG3944	biosynthesis protein
CWM22_RS03545	COG4464	protein tyrosine phosphatase activity
CWM22_RS03555	COG3177	Filamentation induced by cAMP protein fic
CWM22_RS03560	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CWM22_RS03580	COG1442	glycosyl transferase family 8
CWM22_RS03580	COG1216	Glycosyl transferase, family 2
CWM22_RS03605	COG3475	LICD family
CWM22_RS03610	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CWM22_RS03630	COG4750	Nucleotidyl transferase
CWM22_RS03640	COG0562	UDP-galactopyranose mutase
CWM22_RS03645	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CWM22_RS03660	COG0436	Aminotransferase
CWM22_RS03685	COG0534	Mate efflux family protein
CWM22_RS03690	COG0251	oxidation-reduction process
CWM22_RS03695	COG1660	Displays ATPase and GTPase activities
CWM22_RS03700	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CWM22_RS03705	COG1481	regulation of sporulation
CWM22_RS03720	COG0454	-acetyltransferase
CWM22_RS03725	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CWM22_RS03730	COG0549	Belongs to the carbamate kinase family
CWM22_RS03735	COG1288	antiporter activity
CWM22_RS03740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CWM22_RS03745	COG1438	arginine binding
CWM22_RS03750	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CWM22_RS03755	COG0363	glucosamine-6-phosphate deaminase activity
CWM22_RS03775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CWM22_RS03780	COG1696	Membrane protein involved in D-alanine export
CWM22_RS03785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CWM22_RS03790	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CWM22_RS03800	COG0435	Glutathione S-transferase
CWM22_RS03805	COG1187	pseudouridine synthase activity
CWM22_RS03810	COG0386	Belongs to the glutathione peroxidase family
CWM22_RS03820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWM22_RS03825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWM22_RS03830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CWM22_RS03835	COG1120	ATPase activity
CWM22_RS03840	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CWM22_RS03845	COG0204	Acyl-transferase
CWM22_RS03850	COG1596	polysaccharide export
CWM22_RS03850	COG1555	photosystem II stabilization
CWM22_RS03855	COG2333	competence protein COMEC
CWM22_RS03855	COG0658	competence protein
CWM22_RS03865	COG1466	dna polymerase III delta subunit
CWM22_RS03870	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CWM22_RS03875	COG0737	Belongs to the 5'-nucleotidase family
CWM22_RS03965	COG0556	nucleotide-excision repair
CWM22_RS04050	COG1475	DNA binding
CWM22_RS04190	COG0038	chloride channel
CWM22_RS04195	COG1605	Chorismate mutase
CWM22_RS04195	COG0287	Prephenate dehydrogenase
CWM22_RS04205	COG0716	FMN binding
CWM22_RS04210	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CWM22_RS04240	COG0772	Belongs to the SEDS family
CWM22_RS04245	COG0693	protein deglycase activity
CWM22_RS04250	COG0187	DNA topoisomerase II activity
CWM22_RS04255	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CWM22_RS04260	COG0560	Phosphoserine phosphatase
CWM22_RS04310	COG2706	6-phosphogluconolactonase activity
CWM22_RS04315	COG0628	permease
CWM22_RS04325	COG3527	Alpha-acetolactate decarboxylase
CWM22_RS04330	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CWM22_RS04355	COG3842	ATPase activity
CWM22_RS04405	COG1216	Glycosyl transferase, family 2
CWM22_RS04405	COG1442	glycosyl transferase family 8
CWM22_RS04415	COG1442	glycosyl transferase family 8
CWM22_RS04415	COG1216	Glycosyl transferase, family 2
CWM22_RS04425	COG1215	transferase activity, transferring glycosyl groups
CWM22_RS04430	COG1442	glycosyl transferase family 8
CWM22_RS04435	COG1442	glycosyl transferase family 8
CWM22_RS04450	COG1215	transferase activity, transferring glycosyl groups
CWM22_RS04455	COG0201	protein transport
CWM22_RS04530	COG0488	(ABC) transporter
CWM22_RS04545	COG2226	methyltransferase
CWM22_RS04550	COG3442	glutamine amidotransferase
CWM22_RS04555	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CWM22_RS04570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CWM22_RS04575	COG0488	(ABC) transporter
CWM22_RS04605	COG1573	uracil-dna glycosylase
CWM22_RS04615	COG1704	LemA family
CWM22_RS04625	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CWM22_RS04630	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CWM22_RS04660	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CWM22_RS04665	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CWM22_RS04675	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CWM22_RS04680	COG0813	purine-nucleoside phosphorylase activity
CWM22_RS04685	COG0058	SHG alpha-glucan phosphorylase activity
CWM22_RS04695	COG1724	mRNA binding
CWM22_RS04705	COG0582	viral genome integration into host DNA
CWM22_RS04715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CWM22_RS04730	COG1216	Glycosyl transferase, family 2
CWM22_RS04745	COG1051	belongs to the nudix hydrolase family
CWM22_RS04750	COG0647	UMP catabolic process
CWM22_RS04760	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CWM22_RS04765	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CWM22_RS04770	COG1970	mechanosensitive ion channel activity
CWM22_RS04775	COG0358	DNA primase activity
CWM22_RS04780	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CWM22_RS04785	COG2151	metal-sulfur cluster biosynthetic enzyme
CWM22_RS04825	COG1131	(ABC) transporter
CWM22_RS04830	COG2188	Transcriptional regulator
CWM22_RS04840	COG0205	6-phosphofructokinase activity
CWM22_RS04845	COG0469	pyruvate kinase activity
CWM22_RS04865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CWM22_RS04870	COG0657	acetylesterase activity
CWM22_RS04870	COG2755	lipolytic protein G-D-S-L family
CWM22_RS04880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CWM22_RS04885	COG0765	amino acid transport
CWM22_RS04890	COG1126	abc transporter atp-binding protein
CWM22_RS04895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWM22_RS04905	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CWM22_RS04920	COG1846	Transcriptional regulator
CWM22_RS04925	COG3759	membrane
CWM22_RS04945	COG1695	Transcriptional regulator
CWM22_RS04960	COG2195	Cleaves the N-terminal amino acid of tripeptides
CWM22_RS04965	COG0561	phosphatase activity
CWM22_RS04985	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CWM22_RS05000	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CWM22_RS05005	COG0196	riboflavin kinase activity
CWM22_RS05010	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CWM22_RS05015	COG1393	Belongs to the ArsC family
CWM22_RS05020	COG4476	Belongs to the UPF0223 family
CWM22_RS05025	COG0483	inositol monophosphate 1-phosphatase activity
CWM22_RS05030	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CWM22_RS05030	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CWM22_RS05040	COG0573	inorganic phosphate transmembrane transporter activity
CWM22_RS05045	COG0581	inorganic phosphate transmembrane transporter activity
CWM22_RS05050	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CWM22_RS05055	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CWM22_RS05070	COG0745	RESPONSE REGULATOR receiver
CWM22_RS05075	COG5002	protein histidine kinase activity
CWM22_RS05090	COG1072	(Pantothenic acid kinase))
CWM22_RS05095	COG2813	Specifically methylates the guanine in position
CWM22_RS05100	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CWM22_RS05110	COG0295	cytidine deaminase activity
CWM22_RS05115	COG1744	ABC transporter substrate-binding protein PnrA-like
CWM22_RS05120	COG3845	ABC transporter
CWM22_RS05125	COG4603	Belongs to the binding-protein-dependent transport system permease family
CWM22_RS05130	COG1079	Belongs to the binding-protein-dependent transport system permease family
CWM22_RS05135	COG0039	L-malate dehydrogenase activity
CWM22_RS05140	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CWM22_RS05145	COG3764	Sortase (surface protein transpeptidase)
CWM22_RS05165	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CWM22_RS05175	COG0489	protein tyrosine kinase activity
CWM22_RS05185	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CWM22_RS05190	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CWM22_RS05205	COG0438	transferase activity, transferring glycosyl groups
CWM22_RS05215	COG1215	transferase activity, transferring glycosyl groups
CWM22_RS05255	COG1215	transferase activity, transferring glycosyl groups
CWM22_RS05260	COG1215	transferase activity, transferring glycosyl groups
CWM22_RS05265	COG1216	Glycosyl transferase, family 2
CWM22_RS05270	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CWM22_RS05270	COG1215	transferase activity, transferring glycosyl groups
CWM22_RS05275	COG0463	Glycosyl transferase, family 2
CWM22_RS05315	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CWM22_RS05320	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CWM22_RS05335	COG1104	cysteine desulfurase activity
CWM22_RS05345	COG4116	CYTH
CWM22_RS05350	COG2357	RelA SpoT domain protein
CWM22_RS05355	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CWM22_RS05360	COG0564	pseudouridine synthase activity
CWM22_RS05365	COG0280	phosphate acetyltransferase
CWM22_RS05370	COG1132	(ABC) transporter
CWM22_RS05375	COG1132	(ABC) transporter
CWM22_RS05385	COG1194	a g-specific adenine glycosylase
CWM22_RS05390	COG1396	sequence-specific DNA binding
CWM22_RS05405	COG1454	alcohol dehydrogenase
CWM22_RS05410	COG2873	o-acetylhomoserine
CWM22_RS05430	COG4372	Transposase
CWM22_RS05435	COG0488	(ABC) transporter
CWM22_RS05445	COG1126	abc transporter atp-binding protein
CWM22_RS05490	COG0270	DNA (cytosine-5-)-methyltransferase activity
CWM22_RS05540	COG1192	Involved in chromosome partitioning
CWM22_RS05665	COG1192	Involved in chromosome partitioning
CWM22_RS05740	COG1475	DNA binding
CWM22_RS05745	COG4443	Transcriptional Coactivator p15 (PC4)
CWM22_RS05825	COG3843	relaxase mobilization nuclease domain protein
CWM22_RS05850	COG1131	(ABC) transporter
CWM22_RS05900	COG1396	sequence-specific DNA binding
CWM22_RS05925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWM22_RS05930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWM22_RS05940	COG0297	glycogen (starch) synthase activity
CWM22_RS05950	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CWM22_RS05960	COG0543	2 iron, 2 sulfur cluster binding
CWM22_RS05965	COG0167	dihydroorotate dehydrogenase activity
CWM22_RS05970	COG0284	orotidine-5'-phosphate decarboxylase activity
CWM22_RS05975	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CWM22_RS05985	COG0463	Glycosyl transferase, family 2
CWM22_RS05990	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CWM22_RS06000	COG0737	Belongs to the 5'-nucleotidase family
CWM22_RS06015	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CWM22_RS06020	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CWM22_RS06030	COG1272	protein, Hemolysin III
CWM22_RS06040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CWM22_RS06040	COG0425	Belongs to the sulfur carrier protein TusA family
CWM22_RS06045	COG0110	maltose O-acetyltransferase activity
CWM22_RS06050	COG0758	DNA mediated transformation
CWM22_RS06055	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CWM22_RS06060	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CWM22_RS06065	COG0222	ribosome binding
CWM22_RS06115	COG1705	Flagellar rod assembly protein muramidase FlgJ
CWM22_RS06115	COG3942	CHAP domain
CWM22_RS06155	COG0827	DNA restriction-modification system
CWM22_RS06175	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CWM22_RS06195	COG3843	relaxase mobilization nuclease domain protein
CWM22_RS06210	COG4806	L-rhamnose isomerase
CWM22_RS06210	COG1070	Carbohydrate kinase
CWM22_RS06230	COG1175	transmembrane transport
CWM22_RS06235	COG0395	ABC-type sugar transport system, permease component
CWM22_RS06290	COG0270	DNA (cytosine-5-)-methyltransferase activity
CWM22_RS06460	COG1475	DNA binding
CWM22_RS06465	COG4443	Transcriptional Coactivator p15 (PC4)
CWM22_RS06530	COG1396	sequence-specific DNA binding
CWM22_RS06535	COG0542	response to heat
CWM22_RS06540	COG0613	PHP domain protein
CWM22_RS06560	COG3843	relaxase mobilization nuclease domain protein
CWM22_RS06565	COG2205	protein histidine kinase activity
CWM22_RS06570	COG0745	RESPONSE REGULATOR receiver
CWM22_RS06630	COG0647	UMP catabolic process
CWM22_RS06640	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CWM22_RS06650	COG2382	esterase
CWM22_RS06675	COG1136	(ABC) transporter
CWM22_RS06680	COG0577	efflux transmembrane transporter activity
CWM22_RS06695	COG0745	RESPONSE REGULATOR receiver
CWM22_RS06700	COG2205	protein histidine kinase activity
CWM22_RS06700	COG0784	Response regulator, receiver
CWM22_RS06710	COG4974	Belongs to the 'phage' integrase family
CWM22_RS06725	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CWM22_RS06730	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CWM22_RS06735	COG2188	Transcriptional regulator
CWM22_RS06800	COG4268	DNA restriction-modification system
CWM22_RS06805	COG1401	restriction endodeoxyribonuclease activity
CWM22_RS06835	COG4372	Transposase
CWM22_RS06850	COG4221	oxidoreductase activity
CWM22_RS06855	COG0741	lytic transglycosylase activity
CWM22_RS06865	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CWM22_RS06875	COG0009	L-threonylcarbamoyladenylate synthase
CWM22_RS06880	COG2890	protein-(glutamine-N5) methyltransferase activity
CWM22_RS06885	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CWM22_RS06910	COG0481	GTPase activity
CWM22_RS06925	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CWM22_RS06935	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CWM22_RS06940	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CWM22_RS06955	COG1940	carbohydrate kinase activity
CWM22_RS06965	COG0488	(ABC) transporter
CWM22_RS06970	COG0617	tRNA 3'-terminal CCA addition
CWM22_RS06975	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CWM22_RS06980	COG1307	EDD domain protein, DegV family
CWM22_RS06990	COG3583	domain protein
CWM22_RS06995	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWM22_RS06995	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWM22_RS06995	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWM22_RS07000	COG1105	Belongs to the carbohydrate kinase PfkB family
CWM22_RS07005	COG1349	DNA-binding transcription factor activity
CWM22_RS07010	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CWM22_RS07015	COG0336	Belongs to the RNA methyltransferase TrmD family
CWM22_RS07020	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CWM22_RS07030	COG0534	Mate efflux family protein
CWM22_RS07040	COG1136	(ABC) transporter
CWM22_RS07040	COG0577	efflux transmembrane transporter activity
CWM22_RS07060	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CWM22_RS07065	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CWM22_RS07090	COG0038	chloride channel
CWM22_RS07100	COG1177	transmembrane transport
CWM22_RS07105	COG1176	ABC-type spermidine putrescine transport system, permease component I
CWM22_RS07115	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CWM22_RS07120	COG0083	homoserine kinase activity
CWM22_RS07125	COG0460	homoserine dehydrogenase
CWM22_RS07130	COG0726	polysaccharide deacetylase
CWM22_RS07135	COG1132	(ABC) transporter
CWM22_RS07150	COG0228	four-way junction DNA binding
CWM22_RS07160	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CWM22_RS07165	COG2136	Putative SAM-dependent methyltransferase
CWM22_RS07165	COG2521	methyltransferase
CWM22_RS07175	COG0505	Belongs to the CarA family
CWM22_RS07180	COG0540	Belongs to the ATCase OTCase family
CWM22_RS07185	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CWM22_RS07195	COG2824	Alkylphosphonate utilization operon protein PhnA
CWM22_RS07200	COG0564	pseudouridine synthase activity
CWM22_RS07220	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CWM22_RS07225	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CWM22_RS07230	COG1114	Component of the transport system for branched-chain amino acids
CWM22_RS07235	COG0301	tRNA thio-modification
CWM22_RS07240	COG1104	cysteine desulfurase activity
CWM22_RS07265	COG0539	negative regulation of cytoplasmic translation
CWM22_RS07285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CWM22_RS07295	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CWM22_RS07305	COG2184	nucleotidyltransferase activity
CWM22_RS07310	COG0187	DNA topoisomerase II activity
CWM22_RS07325	COG1074	ATP-dependent DNA helicase activity
CWM22_RS07330	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CWM22_RS07365	COG1131	(ABC) transporter
CWM22_RS07395	COG1011	Hydrolase
CWM22_RS07405	COG0210	DNA helicase
CWM22_RS07410	COG3177	Filamentation induced by cAMP protein fic
CWM22_RS07430	COG1164	Oligoendopeptidase f
CWM22_RS07445	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CWM22_RS07450	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CWM22_RS07455	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CWM22_RS07465	COG0446	pyridine nucleotide-disulphide oxidoreductase
CWM22_RS07475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CWM22_RS07480	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CWM22_RS07505	COG1882	Formate acetyltransferase
CWM22_RS07510	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CWM22_RS07515	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CWM22_RS07520	COG1447	Phosphotransferase system cellobiose-specific component IIA
CWM22_RS07530	COG1349	DNA-binding transcription factor activity
CWM22_RS07535	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CWM22_RS07560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CWM22_RS07570	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CWM22_RS07580	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CWM22_RS07585	COG4684	Psort location CytoplasmicMembrane, score
CWM22_RS07590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CWM22_RS07595	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CWM22_RS07605	COG0077	Prephenate dehydratase
CWM22_RS07610	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CWM22_RS07620	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CWM22_RS07625	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CWM22_RS07630	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CWM22_RS07635	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CWM22_RS07645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CWM22_RS07645	COG1116	anion transmembrane transporter activity
CWM22_RS07650	COG4120	Belongs to the binding-protein-dependent transport system permease family
CWM22_RS07670	COG4372	Transposase
CWM22_RS07705	COG3684	Belongs to the aldolase LacD family
CWM22_RS07715	COG3679	Belongs to the UPF0342 family
CWM22_RS07720	COG0287	Prephenate dehydrogenase
CWM22_RS07725	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CWM22_RS07730	COG0710	3-dehydroquinate dehydratase activity
CWM22_RS07735	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CWM22_RS07740	COG1368	sulfuric ester hydrolase activity
CWM22_RS07755	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CWM22_RS07765	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CWM22_RS07800	COG1216	Glycosyl transferase, family 2
CWM22_RS07815	COG1216	Glycosyl transferase, family 2
CWM22_RS07815	COG1442	glycosyl transferase family 8
CWM22_RS07820	COG1442	glycosyl transferase family 8
CWM22_RS07850	COG1442	glycosyl transferase family 8
CWM22_RS07850	COG1216	Glycosyl transferase, family 2
CWM22_RS07885	COG1091	dTDP-4-dehydrorhamnose reductase activity
CWM22_RS07890	COG1088	dTDP-glucose 4,6-dehydratase activity
CWM22_RS07905	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CWM22_RS07915	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CWM22_RS07920	COG2384	SAM-dependent methyltransferase
CWM22_RS07935	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CWM22_RS07945	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CWM22_RS07945	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CWM22_RS07950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CWM22_RS07955	COG2217	Heavy metal translocating P-type atpase
CWM22_RS07960	COG0300	oxidoreductase activity
CWM22_RS07965	COG1234	tRNA 3'-trailer cleavage
CWM22_RS07975	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CWM22_RS07980	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CWM22_RS07995	COG2807	transmembrane transport
CWM22_RS08000	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CWM22_RS08010	COG2610	gluconate transmembrane transporter activity
CWM22_RS08030	COG0302	gtp cyclohydrolase
CWM22_RS08035	COG1051	belongs to the nudix hydrolase family
CWM22_RS08065	COG0072	phenylalanine-tRNA ligase activity
CWM22_RS08065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CWM22_RS08095	COG1028	Short-chain dehydrogenase reductase Sdr
CWM22_RS08100	COG1312	Catalyzes the dehydration of D-mannonate
CWM22_RS08110	COG0800	Aldolase
CWM22_RS08120	COG3250	beta-galactosidase activity
CWM22_RS08130	COG2211	Major facilitator Superfamily
CWM22_RS08145	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CWM22_RS08155	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CWM22_RS08160	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CWM22_RS08165	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CWM22_RS08170	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CWM22_RS08175	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CWM22_RS08180	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CWM22_RS08185	COG0356	it plays a direct role in the translocation of protons across the membrane
CWM22_RS08195	COG1597	lipid kinase activity
CWM22_RS08205	COG0701	Predicted permease
CWM22_RS08210	COG3689	TIGRFAM TIGR03943 family protein
CWM22_RS08215	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CWM22_RS08250	COG4372	Transposase
CWM22_RS08255	COG0552	protein localization to endoplasmic reticulum
CWM22_RS08260	COG0561	phosphatase activity
CWM22_RS08265	COG0561	phosphatase activity
CWM22_RS08270	COG1196	nuclear chromosome segregation
CWM22_RS08300	COG1012	belongs to the aldehyde dehydrogenase family
CWM22_RS08310	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWM22_RS08320	COG0538	isocitrate dehydrogenase activity
CWM22_RS08325	COG0372	Belongs to the citrate synthase family
CWM22_RS08330	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CWM22_RS08335	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CWM22_RS08340	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CWM22_RS08345	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CWM22_RS08380	COG1476	TRANSCRIPTIONal
CWM22_RS08400	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CWM22_RS08410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CWM22_RS08415	COG4122	O-methyltransferase activity
CWM22_RS08445	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CWM22_RS08445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CWM22_RS08495	COG0531	amino acid
CWM22_RS08505	COG0708	Exodeoxyribonuclease III
CWM22_RS08555	COG1393	Belongs to the ArsC family
CWM22_RS08560	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CWM22_RS08565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CWM22_RS08575	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CWM22_RS08585	COG4467	Involved in initiation control of chromosome replication
CWM22_RS08590	COG0470	DNA polymerase III
CWM22_RS08595	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CWM22_RS08600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CWM22_RS08620	COG0517	IMP dehydrogenase activity
CWM22_RS08675	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CWM22_RS08680	COG0366	Alpha amylase catalytic
CWM22_RS08685	COG0366	Alpha amylase catalytic
CWM22_RS08690	COG0395	ABC-type sugar transport system, permease component
CWM22_RS08695	COG1175	transmembrane transport
CWM22_RS08700	COG1653	transport
CWM22_RS08715	COG1653	transport
CWM22_RS08725	COG2207	Transcriptional regulator
CWM22_RS08730	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CWM22_RS08735	COG0626	cystathionine gamma-synthase activity
CWM22_RS08755	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CWM22_RS08760	COG2827	Endonuclease containing a URI domain
CWM22_RS08780	COG0640	Transcriptional regulator
CWM22_RS08785	COG0513	Belongs to the DEAD box helicase family
CWM22_RS08795	COG0823	Involved in the tonB-independent uptake of proteins
CWM22_RS08830	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CWM22_RS08840	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CWM22_RS08860	COG4372	Transposase
CWM22_RS08880	COG1181	Belongs to the D-alanine--D-alanine ligase family
CWM22_RS08885	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CWM22_RS08890	COG0768	penicillin binding
CWM22_RS08895	COG0488	(ABC) transporter
CWM22_RS08905	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CWM22_RS08925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWM22_RS08930	COG0765	amino acid transport
CWM22_RS08935	COG0765	amino acid transport
CWM22_RS08950	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CWM22_RS09010	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CWM22_RS09085	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CWM22_RS09085	COG0551	DNA topoisomerase type I activity
CWM22_RS09210	COG0438	transferase activity, transferring glycosyl groups
CWM22_RS09225	COG1609	Transcriptional regulator
CWM22_RS09235	COG0343	queuine tRNA-ribosyltransferase activity
CWM22_RS09245	COG1832	CoA-binding protein
CWM22_RS09255	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CWM22_RS09255	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CWM22_RS09295	COG1136	(ABC) transporter
CWM22_RS09320	COG1131	(ABC) transporter
CWM22_RS09345	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CWM22_RS09350	COG0583	DNA-binding transcription factor activity
CWM22_RS09360	COG0110	maltose O-acetyltransferase activity
CWM22_RS09365	COG2217	Heavy metal translocating P-type atpase
CWM22_RS09380	COG1063	alcohol dehydrogenase
CWM22_RS09405	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CWM22_RS09410	COG0557	exoribonuclease II activity
CWM22_RS09415	COG0017	Asparaginyl-tRNA synthetase
CWM22_RS09425	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CWM22_RS09430	COG2814	Major facilitator Superfamily
CWM22_RS09440	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CWM22_RS09450	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CWM22_RS09455	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CWM22_RS09470	COG1737	Transcriptional regulator
CWM22_RS09485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CWM22_RS09500	COG0395	ABC-type sugar transport system, permease component
CWM22_RS09505	COG1175	transmembrane transport
CWM22_RS09525	COG1132	(ABC) transporter
CWM22_RS09530	COG1132	(ABC) transporter
CWM22_RS09685	COG4372	Transposase
CWM22_RS09735	COG0582	viral genome integration into host DNA
CWM22_RS09820	COG3561	AntA/AntB antirepressor
CWM22_RS09860	COG3645	SOS response
CWM22_RS09865	COG4974	Belongs to the 'phage' integrase family
CWM22_RS09890	COG2177	Part of the ABC transporter FtsEX involved in
CWM22_RS09895	COG2884	Cell division ATP-binding protein ftsE
CWM22_RS09905	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CWM22_RS09920	COG1705	Flagellar rod assembly protein muramidase FlgJ
CWM22_RS09925	COG0860	N-Acetylmuramoyl-L-alanine amidase
CWM22_RS09990	COG1078	dGTPase activity
CWM22_RS10000	COG0149	triose-phosphate isomerase activity
CWM22_RS10005	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CWM22_RS10020	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CWM22_RS10025	COG0772	Belongs to the SEDS family
CWM22_RS10045	COG3859	Proton-coupled thiamine transporter YuaJ
CWM22_RS10055	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CWM22_RS10065	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CWM22_RS10075	COG0577	efflux transmembrane transporter activity
CWM22_RS10080	COG1136	(ABC) transporter
CWM22_RS10085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CWM22_RS10090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CWM22_RS10095	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CWM22_RS10100	COG1268	BioY protein
CWM22_RS10105	COG4443	Transcriptional Coactivator p15 (PC4)
CWM22_RS10115	COG0826	peptidase U32
CWM22_RS10130	COG0789	Transcriptional regulator
CWM22_RS10140	COG1227	inorganic diphosphatase activity
CWM22_RS10150	COG1733	regulation of RNA biosynthetic process
CWM22_RS10155	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CWM22_RS10175	COG2514	catechol 2,3-dioxygenase activity
CWM22_RS10190	COG1472	Belongs to the glycosyl hydrolase 3 family
CWM22_RS10195	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CWM22_RS10200	COG1253	flavin adenine dinucleotide binding
CWM22_RS10205	COG1119	ATPase activity
CWM22_RS10220	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CWM22_RS10240	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CWM22_RS10245	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CWM22_RS10250	COG0133	tryptophan synthase activity
CWM22_RS10265	COG4470	Protein conserved in bacteria
CWM22_RS10270	COG3480	Lon protease (S16) C-terminal proteolytic domain
CWM22_RS10275	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CWM22_RS10280	COG0742	ribosomal rna small subunit methyltransferase
CWM22_RS10290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CWM22_RS10295	COG4483	Protein conserved in bacteria
CWM22_RS10300	COG2197	response regulator
CWM22_RS10305	COG4585	Histidine kinase
CWM22_RS10310	COG0842	Transport permease protein
CWM22_RS10315	COG1131	(ABC) transporter
CWM22_RS10335	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CWM22_RS10345	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CWM22_RS10345	COG2755	lipolytic protein G-D-S-L family
CWM22_RS10350	COG0671	phosphoesterase, PA-phosphatase related
CWM22_RS10355	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CWM22_RS10365	COG0747	negative chemotaxis
CWM22_RS10370	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CWM22_RS10375	COG1187	pseudouridine synthase activity
CWM22_RS10380	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CWM22_RS10385	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CWM22_RS10390	COG0582	viral genome integration into host DNA
CWM22_RS10410	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CWM22_RS10415	COG3763	UPF0154 protein
CWM22_RS10425	COG3579	cysteine-type endopeptidase activity
CWM22_RS10440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CWM22_RS10445	COG1254	Belongs to the acylphosphatase family
CWM22_RS10455	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CWM22_RS10460	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CWM22_RS10470	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CWM22_RS10480	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CWM22_RS10510	COG1160	GTP binding
CWM22_RS10520	COG1484	DNA-dependent DNA replication
CWM22_RS10530	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CWM22_RS10535	COG0628	permease
CWM22_RS10545	COG0745	RESPONSE REGULATOR receiver
CWM22_RS10550	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CWM22_RS10560	COG0492	ferredoxin-NADP+ reductase activity
CWM22_RS10570	COG0513	Belongs to the DEAD box helicase family
CWM22_RS10595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CWM22_RS10600	COG0768	penicillin binding
CWM22_RS10610	COG0275	rRNA processing
CWM22_RS10660	COG4939	FMN-binding domain protein
CWM22_RS10665	COG0142	geranyltranstransferase activity
CWM22_RS10670	COG1252	NADH dehydrogenase
CWM22_RS10685	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CWM22_RS10690	COG0569	domain protein
CWM22_RS10695	COG0534	Mate efflux family protein
CWM22_RS10710	COG4224	UPF0291 protein
CWM22_RS10715	COG0751	glycine-tRNA ligase activity
CWM22_RS10740	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CWM22_RS10745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CWM22_RS10750	COG1464	Belongs to the NlpA lipoprotein family
CWM22_RS10760	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CWM22_RS10770	COG0444	Belongs to the ABC transporter superfamily
CWM22_RS10775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CWM22_RS10780	COG0601	transmembrane transport
CWM22_RS10790	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CWM22_RS10805	COG2252	PERMEase
CWM22_RS10810	COG0561	phosphatase activity
CWM22_RS10820	COG3715	PTS system
CWM22_RS10825	COG3716	PTS system mannose fructose sorbose family IID component
CWM22_RS10860	COG3177	Filamentation induced by cAMP protein fic
CWM22_RS10870	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CWM22_RS10885	COG1266	CAAX protease self-immunity
CWM22_RS10890	COG1266	CAAX protease self-immunity
CWM22_RS10910	COG0439	Biotin carboxylase
CWM22_RS10930	COG1028	Short-chain dehydrogenase reductase Sdr
CWM22_RS10935	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CWM22_RS10950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CWM22_RS10960	COG1024	Enoyl-CoA hydratase
CWM22_RS10965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CWM22_RS10970	COG0527	aspartate kinase activity
CWM22_RS10975	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CWM22_RS10980	COG0736	holo-[acyl-carrier-protein] synthase activity
CWM22_RS10985	COG0653	protein targeting
CWM22_RS10995	COG1940	carbohydrate kinase activity
CWM22_RS11000	COG2190	(PTS) system
CWM22_RS11000	COG1263	PTS System
CWM22_RS11000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWM22_RS11005	COG1621	beta-fructofuranosidase activity
CWM22_RS11010	COG1609	Transcriptional regulator
CWM22_RS11015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CWM22_RS11030	COG0006	proline dipeptidase activity
CWM22_RS11055	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CWM22_RS11070	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CWM22_RS11075	COG0629	single-stranded DNA binding
CWM22_RS11085	COG0095	Lipoate-protein ligase
CWM22_RS11090	COG2723	6-phospho-beta-galactosidase activity
CWM22_RS11105	COG2723	6-phospho-beta-galactosidase activity
CWM22_RS11110	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CWM22_RS11120	COG1447	Phosphotransferase system cellobiose-specific component IIA
CWM22_RS11125	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWM22_RS11125	COG3711	transcriptional antiterminator
CWM22_RS11140	COG4095	Psort location CytoplasmicMembrane, score
CWM22_RS11145	COG2723	6-phospho-beta-galactosidase activity
CWM22_RS11155	COG2723	6-phospho-beta-galactosidase activity
CWM22_RS11160	COG2207	Transcriptional regulator
CWM22_RS11170	COG1263	PTS System
CWM22_RS11170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWM22_RS11170	COG2190	(PTS) system
CWM22_RS11175	COG3711	transcriptional antiterminator
CWM22_RS11190	COG0508	dehydrogenase complex catalyzes the overall conversion of
CWM22_RS11200	COG0022	dehydrogenase e1 component
CWM22_RS11200	COG0508	dehydrogenase complex catalyzes the overall conversion of
CWM22_RS11205	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CWM22_RS11210	COG2860	membrane
CWM22_RS11235	COG1396	sequence-specific DNA binding
CWM22_RS11255	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CWM22_RS11260	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CWM22_RS11270	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CWM22_RS11275	COG0195	Participates in both transcription termination and antitermination
CWM22_RS11290	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CWM22_RS11300	COG4473	ABC transporter
CWM22_RS11305	COG1131	(ABC) transporter
CWM22_RS11310	COG0537	adenosine 5'-monophosphoramidase activity
CWM22_RS11325	COG1316	TRANSCRIPTIONal
CWM22_RS11335	COG0802	atpase or kinase
CWM22_RS11340	COG1461	Dihydroxyacetone kinase
CWM22_RS11350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CWM22_RS11355	COG0601	transmembrane transport
CWM22_RS11360	COG4608	Belongs to the ABC transporter superfamily
CWM22_RS11375	COG1686	Belongs to the peptidase S11 family
CWM22_RS11390	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CWM22_RS11395	COG0719	Fe-S assembly protein
CWM22_RS11405	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CWM22_RS11410	COG4862	establishment of competence for transformation
CWM22_RS11415	COG1968	undecaprenyl-diphosphatase activity
CWM22_RS11420	COG0765	amino acid transport
CWM22_RS11440	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CWM22_RS11445	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CWM22_RS11450	COG0440	acetolactate synthase activity
CWM22_RS11455	COG0028	Belongs to the TPP enzyme family
CWM22_RS11460	COG0463	Glycosyl transferase, family 2
CWM22_RS11475	COG0129	dihydroxy-acid dehydratase activity
CWM22_RS11485	COG2151	metal-sulfur cluster biosynthetic enzyme
CWM22_RS11515	COG5290	Psort location Cytoplasmic, score
CWM22_RS11540	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CWM22_RS11560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CWM22_RS11585	COG3842	ATPase activity
CWM22_RS11590	COG1442	glycosyl transferase family 8
CWM22_RS11600	COG4753	response regulator
CWM22_RS11600	COG2207	Transcriptional regulator
CWM22_RS11605	COG2972	Histidine kinase
CWM22_RS11615	COG1653	transport
CWM22_RS11620	COG0395	ABC-type sugar transport system, permease component
CWM22_RS11625	COG1175	transmembrane transport
CWM22_RS11640	COG0383	alpha-mannosidase activity
CWM22_RS11660	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CWM22_RS11685	COG1045	serine acetyltransferase
CWM22_RS11690	COG1185	polyribonucleotide nucleotidyltransferase activity
CWM22_RS11700	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CWM22_RS11730	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CWM22_RS11745	COG1187	pseudouridine synthase activity
CWM22_RS11765	COG0242	peptide deformylase activity
CWM22_RS11785	COG1136	(ABC) transporter
CWM22_RS11800	COG0066	3-isopropylmalate dehydratase activity
CWM22_RS11825	COG2309	aminopeptidase activity
CWM22_RS11835	COG2176	DNA-directed DNA polymerase activity
CWM22_RS11840	COG2376	Dihydroxyacetone kinase
CWM22_RS11850	COG2376	Dihydroxyacetone kinase
CWM22_RS11855	COG1461	Dihydroxyacetone kinase
CWM22_RS11860	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CWM22_RS11865	COG0442	prolyl-tRNA aminoacylation
CWM22_RS11875	COG4589	Belongs to the CDS family
CWM22_RS11880	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CWM22_RS11885	COG1862	Preprotein translocase
CWM22_RS11895	COG1181	Belongs to the D-alanine--D-alanine ligase family
CWM22_RS11895	COG2918	glutathione biosynthetic process
CWM22_RS11900	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CWM22_RS11905	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CWM22_RS11915	COG0542	response to heat
CWM22_RS11920	COG4463	regulation of RNA biosynthetic process
CWM22_RS11935	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CWM22_RS11965	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CWM22_RS11970	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CWM22_RS11975	COG0492	ferredoxin-NADP+ reductase activity
CWM22_RS11980	COG0564	pseudouridine synthase activity
CWM22_RS11985	COG4372	Transposase
CWM22_RS12065	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CWM22_RS12085	COG1564	THIamine pyrophosphokinase
CWM22_RS12095	COG1162	GTPase activity
CWM22_RS12125	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CWM22_RS12130	COG1132	(ABC) transporter
CWM22_RS12170	COG4115	mRNA cleavage
CWM22_RS12205	COG0084	hydrolase, TatD family'
CWM22_RS12215	COG1847	R3H domain protein
CWM22_RS12225	COG0594	ribonuclease P activity
CWM22_RS12230	COG0165	Argininosuccinate lyase
CWM22_RS12235	COG0137	argininosuccinate synthase activity
CWM22_RS12250	COG2040	homocysteine
CWM22_RS12255	COG0833	amino acid
CWM22_RS12340	COG0756	dUTP diphosphatase activity
CWM22_RS12360	COG1136	(ABC) transporter
CWM22_RS12360	COG0577	efflux transmembrane transporter activity
CWM22_RS12385	COG2832	Protein of unknown function (DUF454)
CWM22_RS12395	COG3976	FMN-binding domain protein
CWM22_RS12395	COG1053	succinate dehydrogenase
CWM22_RS12395	COG0431	NADPH-dependent FMN reductase
CWM22_RS12410	COG1132	(ABC) transporter
CWM22_RS12415	COG1132	(ABC) transporter
CWM22_RS12425	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CWM22_RS12430	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CWM22_RS12435	COG0705	Rhomboid family
CWM22_RS12440	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CWM22_RS12445	COG1473	amidohydrolase
CWM22_RS12450	COG2171	N-acyltransferase activity
CWM22_RS12455	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CWM22_RS12460	COG0166	Belongs to the GPI family
CWM22_RS12480	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CWM22_RS12505	COG3623	hexulose-6-phosphate isomerase
CWM22_RS12530	COG1523	belongs to the glycosyl hydrolase 13 family
CWM22_RS12540	COG1609	Transcriptional regulator
CWM22_RS12550	COG3942	CHAP domain
CWM22_RS12555	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CWM22_RS12565	COG1447	Phosphotransferase system cellobiose-specific component IIA
CWM22_RS12575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWM22_RS12575	COG3711	transcriptional antiterminator
CWM22_RS12585	COG2723	6-phospho-beta-galactosidase activity
CWM22_RS12590	COG1486	melibiose metabolic process
CWM22_RS12610	COG0584	glycerophosphoryl diester phosphodiesterase
CWM22_RS12615	COG3590	peptidase
CWM22_RS12620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CWM22_RS12625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CWM22_RS12625	COG1321	iron dependent repressor
CWM22_RS12630	COG1121	(ABC) transporter
CWM22_RS12645	COG0803	Belongs to the bacterial solute-binding protein 9 family
CWM22_RS12725	COG3290	protein histidine kinase activity
CWM22_RS12745	COG1490	D-aminoacyl-tRNA deacylase activity
CWM22_RS12755	COG0737	Belongs to the 5'-nucleotidase family
CWM22_RS12760	COG1811	Na channel or pump
CWM22_RS12765	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CWM22_RS12790	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CWM22_RS12815	COG1705	Flagellar rod assembly protein muramidase FlgJ
CWM22_RS12815	COG3942	CHAP domain
CWM22_RS12835	COG0433	COG0433 Predicted ATPase
CWM22_RS12910	COG1674	ftsk spoiiie
CWM22_RS13005	COG1328	CTP reductase activity
CWM22_RS13025	COG4372	Transposase
CWM22_RS13060	COG1438	arginine binding
CWM22_RS13065	COG0018	arginyl-trna synthetase
CWM22_RS13115	COG1131	(ABC) transporter
CWM22_RS13130	COG1640	4-alpha-glucanotransferase
CWM22_RS13135	COG2182	Extracellular solute-binding protein
CWM22_RS13140	COG1175	transmembrane transport
CWM22_RS13145	COG3833	ABC-type maltose transport systems, permease component
CWM22_RS13150	COG5521	maltodextrose utilization protein MalA
CWM22_RS13155	COG1609	Transcriptional regulator
CWM22_RS13160	COG1523	belongs to the glycosyl hydrolase 13 family
CWM22_RS13165	COG1780	Probably involved in ribonucleotide reductase function
CWM22_RS13170	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CWM22_RS13175	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CWM22_RS13190	COG4989	oxidoreductase activity
CWM22_RS13195	COG1216	Glycosyl transferase, family 2
CWM22_RS13215	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CWM22_RS13225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CWM22_RS13230	COG0785	Cytochrome C biogenesis protein
CWM22_RS13240	COG0305	Participates in initiation and elongation during chromosome replication
CWM22_RS13245	COG0359	binds to the 23S rRNA
CWM22_RS13255	COG0445	tRNA wobble uridine modification
CWM22_RS13260	COG0494	nUDIX hydrolase
CWM22_RS13270	COG1051	belongs to the nudix hydrolase family
CWM22_RS13275	COG1733	regulation of RNA biosynthetic process
CWM22_RS13285	COG0482	sulfurtransferase activity
CWM22_RS13290	COG1760	l-serine dehydratase
CWM22_RS13295	COG1760	l-serine dehydratase
CWM22_RS13305	COG0745	RESPONSE REGULATOR receiver
CWM22_RS13310	COG3850	Histidine kinase
CWM22_RS13310	COG5002	protein histidine kinase activity
CWM22_RS13325	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CWM22_RS13330	COG1122	ATPase activity
CWM22_RS13335	COG1122	ATPase activity
CWM22_RS13340	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CWM22_RS13345	COG1426	Protein conserved in bacteria
CWM22_RS13350	COG0612	Peptidase, M16
CWM22_RS13355	COG0612	Peptidase, M16
CWM22_RS13365	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CWM22_RS13370	COG0516	GMP reductase activity
CWM22_RS13370	COG0517	IMP dehydrogenase activity
CWM22_RS13380	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CWM22_RS13385	COG0488	(ABC) transporter
CWM22_RS13415	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CWM22_RS13420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CWM22_RS13425	COG1475	DNA binding