locus-tag	class	description
A7J09_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A7J09_RS00010	COG0592	DNA-directed DNA polymerase activity
A7J09_RS00030	COG0012	GTP binding
A7J09_RS00035	COG0193	aminoacyl-tRNA hydrolase activity
A7J09_RS00040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A7J09_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A7J09_RS00065	COG0037	tRNA processing
A7J09_RS00075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A7J09_RS00205	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A7J09_RS00210	COG0436	Aminotransferase
A7J09_RS00215	COG1381	Involved in DNA repair and RecF pathway recombination
A7J09_RS00220	COG0416	fatty acid biosynthetic process
A7J09_RS00225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7J09_RS00235	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A7J09_RS00250	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A7J09_RS00255	COG0138	bifunctional purine biosynthesis protein purh
A7J09_RS00270	COG3583	domain protein
A7J09_RS00295	COG0151	Belongs to the GarS family
A7J09_RS00300	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A7J09_RS00315	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A7J09_RS00345	COG1131	(ABC) transporter
A7J09_RS00355	COG1132	(ABC) transporter
A7J09_RS00360	COG2255	four-way junction helicase activity
A7J09_RS00365	COG0546	phosphoglycolate phosphatase activity
A7J09_RS00380	COG0285	dihydrofolate synthase activity
A7J09_RS00395	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A7J09_RS00400	COG0632	four-way junction helicase activity
A7J09_RS00405	COG0519	Catalyzes the synthesis of GMP from XMP
A7J09_RS00420	COG1393	Belongs to the ArsC family
A7J09_RS00425	COG4472	Bacterial protein of unknown function (DUF965)
A7J09_RS00430	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A7J09_RS00435	COG3906	Belongs to the UPF0473 family
A7J09_RS00445	COG0051	transcription antitermination factor activity, RNA binding
A7J09_RS00450	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A7J09_RS00455	COG0088	Forms part of the polypeptide exit tunnel
A7J09_RS00460	COG0089	rRNA binding
A7J09_RS00465	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A7J09_RS00470	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A7J09_RS00475	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A7J09_RS00480	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A7J09_RS00485	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A7J09_RS00490	COG0255	Belongs to the universal ribosomal protein uL29 family
A7J09_RS00495	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A7J09_RS00500	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A7J09_RS00505	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A7J09_RS00510	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A7J09_RS00515	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A7J09_RS00520	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A7J09_RS00525	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A7J09_RS00530	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A7J09_RS00535	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A7J09_RS00540	COG1841	ribosomal large subunit assembly
A7J09_RS00550	COG0201	protein transport
A7J09_RS00555	COG0563	adenylate kinase activity
A7J09_RS00560	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A7J09_RS00565	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A7J09_RS00570	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A7J09_RS00580	COG0202	RNA polymerase activity
A7J09_RS00700	COG0582	viral genome integration into host DNA
A7J09_RS00710	COG2946	Replication initiation factor
A7J09_RS00755	COG1121	(ABC) transporter
A7J09_RS00760	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A7J09_RS00765	COG3443	Belongs to the bacterial solute-binding protein 9 family
A7J09_RS00765	COG0803	Belongs to the bacterial solute-binding protein 9 family
A7J09_RS00805	COG1187	pseudouridine synthase activity
A7J09_RS00825	COG0242	peptide deformylase activity
A7J09_RS00835	COG0066	3-isopropylmalate dehydratase activity
A7J09_RS00845	COG0473	3-isopropylmalate dehydrogenase activity
A7J09_RS00865	COG2309	aminopeptidase activity
A7J09_RS00875	COG2176	DNA-directed DNA polymerase activity
A7J09_RS00880	COG2376	Dihydroxyacetone kinase
A7J09_RS00910	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
A7J09_RS00930	COG1045	serine acetyltransferase
A7J09_RS00935	COG1185	polyribonucleotide nucleotidyltransferase activity
A7J09_RS00960	COG4372	Transposase
A7J09_RS00965	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A7J09_RS00970	COG1131	(ABC) transporter
A7J09_RS01020	COG1181	Belongs to the D-alanine--D-alanine ligase family
A7J09_RS01020	COG2918	glutathione biosynthetic process
A7J09_RS01035	COG1862	Preprotein translocase
A7J09_RS01055	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A7J09_RS01060	COG4589	Belongs to the CDS family
A7J09_RS01070	COG0442	prolyl-tRNA aminoacylation
A7J09_RS01075	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
A7J09_RS01080	COG1461	Dihydroxyacetone kinase
A7J09_RS01085	COG2376	Dihydroxyacetone kinase
A7J09_RS01135	COG1175	transmembrane transport
A7J09_RS01140	COG0395	ABC-type sugar transport system, permease component
A7J09_RS01145	COG1653	transport
A7J09_RS01155	COG2972	Histidine kinase
A7J09_RS01165	COG3842	ATPase activity
A7J09_RS01190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A7J09_RS01210	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A7J09_RS01235	COG5290	Psort location Cytoplasmic, score
A7J09_RS01260	COG2151	metal-sulfur cluster biosynthetic enzyme
A7J09_RS01275	COG1442	glycosyl transferase family 8
A7J09_RS01280	COG0129	dihydroxy-acid dehydratase activity
A7J09_RS01295	COG0463	Glycosyl transferase, family 2
A7J09_RS01300	COG0028	Belongs to the TPP enzyme family
A7J09_RS01305	COG0440	acetolactate synthase activity
A7J09_RS01310	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A7J09_RS01315	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A7J09_RS01340	COG0765	amino acid transport
A7J09_RS01345	COG1968	undecaprenyl-diphosphatase activity
A7J09_RS01350	COG4862	establishment of competence for transformation
A7J09_RS01355	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A7J09_RS01370	COG0719	Fe-S assembly protein
A7J09_RS01375	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A7J09_RS01395	COG1686	Belongs to the peptidase S11 family
A7J09_RS01405	COG5433	transposase activity
A7J09_RS01415	COG4608	Belongs to the ABC transporter superfamily
A7J09_RS01420	COG0601	transmembrane transport
A7J09_RS01425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7J09_RS01440	COG0802	atpase or kinase
A7J09_RS01450	COG1316	TRANSCRIPTIONal
A7J09_RS01460	COG0537	adenosine 5'-monophosphoramidase activity
A7J09_RS01465	COG1131	(ABC) transporter
A7J09_RS01470	COG4473	ABC transporter
A7J09_RS01480	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A7J09_RS01490	COG0195	Participates in both transcription termination and antitermination
A7J09_RS01495	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A7J09_RS01505	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A7J09_RS01510	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A7J09_RS01525	COG2860	membrane
A7J09_RS01530	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A7J09_RS01535	COG0508	dehydrogenase complex catalyzes the overall conversion of
A7J09_RS01535	COG0022	dehydrogenase e1 component
A7J09_RS01540	COG0508	dehydrogenase complex catalyzes the overall conversion of
A7J09_RS01560	COG1263	PTS System
A7J09_RS01560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7J09_RS01560	COG2190	(PTS) system
A7J09_RS01575	COG2207	Transcriptional regulator
A7J09_RS01580	COG2723	6-phospho-beta-galactosidase activity
A7J09_RS01585	COG0346	lactoylglutathione lyase activity
A7J09_RS01625	COG0446	pyridine nucleotide-disulphide oxidoreductase
A7J09_RS01625	COG1902	pentaerythritol trinitrate reductase activity
A7J09_RS01660	COG2910	NAD(P)H-binding
A7J09_RS01665	COG1959	2 iron, 2 sulfur cluster binding
A7J09_RS01705	COG0544	peptidyl-prolyl cis-trans isomerase activity
A7J09_RS01725	COG3343	RNA polymerase activity
A7J09_RS01730	COG0504	CTP synthase activity
A7J09_RS01755	COG0191	fructose-bisphosphate aldolase activity
A7J09_RS01760	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A7J09_RS01890	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A7J09_RS01910	COG0589	response to stress
A7J09_RS01915	COG0436	Aminotransferase
A7J09_RS01920	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A7J09_RS01925	COG1335	isochorismatase
A7J09_RS01930	COG0335	large ribosomal subunit rRNA binding
A7J09_RS01945	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A7J09_RS01950	COG0154	amidase activity
A7J09_RS01955	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A7J09_RS01970	COG1609	Transcriptional regulator
A7J09_RS01975	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A7J09_RS01980	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
A7J09_RS01995	COG3142	Participates in the control of copper homeostasis
A7J09_RS02010	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A7J09_RS02020	COG1534	Rna-binding protein
A7J09_RS02025	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A7J09_RS02030	COG1713	HD superfamily hydrolase involved in NAD metabolism
A7J09_RS02045	COG1335	isochorismatase
A7J09_RS02050	COG0799	negative regulation of ribosome biogenesis
A7J09_RS02055	COG2226	methyltransferase
A7J09_RS02085	COG0789	Transcriptional regulator
A7J09_RS02090	COG2348	transferase activity, transferring amino-acyl groups
A7J09_RS02100	COG0242	peptide deformylase activity
A7J09_RS02115	COG1640	4-alpha-glucanotransferase
A7J09_RS02120	COG0058	SHG alpha-glucan phosphorylase activity
A7J09_RS02135	COG2190	(PTS) system
A7J09_RS02135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7J09_RS02135	COG1263	PTS System
A7J09_RS02150	COG0217	transcriptional regulatory protein
A7J09_RS02160	COG4720	Psort location CytoplasmicMembrane, score
A7J09_RS02170	COG1054	Belongs to the UPF0176 family
A7J09_RS02185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7J09_RS02190	COG0765	amino acid transport
A7J09_RS02195	COG1126	abc transporter atp-binding protein
A7J09_RS02200	COG1609	Transcriptional regulator
A7J09_RS02205	COG1523	belongs to the glycosyl hydrolase 13 family
A7J09_RS02230	COG3623	hexulose-6-phosphate isomerase
A7J09_RS02255	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A7J09_RS02290	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A7J09_RS02295	COG2171	N-acyltransferase activity
A7J09_RS02300	COG1473	amidohydrolase
A7J09_RS02305	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A7J09_RS02310	COG0705	Rhomboid family
A7J09_RS02315	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A7J09_RS02320	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A7J09_RS02330	COG1132	(ABC) transporter
A7J09_RS02335	COG1132	(ABC) transporter
A7J09_RS02340	COG0756	dUTP diphosphatase activity
A7J09_RS02385	COG0833	amino acid
A7J09_RS02390	COG2040	homocysteine
A7J09_RS02405	COG1827	regulation of RNA biosynthetic process
A7J09_RS02415	COG0137	argininosuccinate synthase activity
A7J09_RS02420	COG0165	Argininosuccinate lyase
A7J09_RS02425	COG0594	ribonuclease P activity
A7J09_RS02435	COG1847	R3H domain protein
A7J09_RS02455	COG0084	hydrolase, TatD family'
A7J09_RS02510	COG1346	cytolysis
A7J09_RS02515	COG2116	formate transmembrane transporter activity
A7J09_RS02520	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A7J09_RS02525	COG0433	COG0433 Predicted ATPase
A7J09_RS02530	COG0494	nUDIX hydrolase
A7J09_RS02570	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A7J09_RS02575	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A7J09_RS02600	COG0124	histidyl-tRNA synthetase
A7J09_RS02605	COG1064	alcohol dehydrogenase
A7J09_RS02610	COG1012	belongs to the aldehyde dehydrogenase family
A7J09_RS02610	COG1454	alcohol dehydrogenase
A7J09_RS02620	COG4988	ABC transporter
A7J09_RS02625	COG1132	(ABC) transporter
A7J09_RS02640	COG1129	ABC transporter
A7J09_RS02645	COG0534	Mate efflux family protein
A7J09_RS02665	COG1304	FMN binding
A7J09_RS02670	COG1132	(ABC) transporter
A7J09_RS02675	COG1132	(ABC) transporter
A7J09_RS02680	COG3830	Belongs to the UPF0237 family
A7J09_RS02685	COG2848	UPF0210 protein
A7J09_RS02690	COG0588	phosphoglycerate mutase activity
A7J09_RS02695	COG1420	regulation of RNA biosynthetic process
A7J09_RS02700	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A7J09_RS02705	COG0443	Heat shock 70 kDa protein
A7J09_RS02710	COG0484	heat shock protein binding
A7J09_RS02715	COG0095	Lipoate-protein ligase
A7J09_RS02725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7J09_RS02730	COG0765	amino acid transport
A7J09_RS02760	COG2217	Heavy metal translocating P-type atpase
A7J09_RS02775	COG0351	phosphomethylpyrimidine kinase
A7J09_RS02785	COG4475	Protein of unknown function (DUF436)
A7J09_RS02805	COG2723	6-phospho-beta-galactosidase activity
A7J09_RS02825	COG3711	transcriptional antiterminator
A7J09_RS02825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7J09_RS02830	COG1447	Phosphotransferase system cellobiose-specific component IIA
A7J09_RS02840	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A7J09_RS02845	COG2723	6-phospho-beta-galactosidase activity
A7J09_RS02860	COG2723	6-phospho-beta-galactosidase activity
A7J09_RS02865	COG0095	Lipoate-protein ligase
A7J09_RS02875	COG0629	single-stranded DNA binding
A7J09_RS02880	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A7J09_RS02895	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A7J09_RS02900	COG0006	proline dipeptidase activity
A7J09_RS02915	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A7J09_RS02920	COG1609	Transcriptional regulator
A7J09_RS02925	COG1621	beta-fructofuranosidase activity
A7J09_RS02930	COG1263	PTS System
A7J09_RS02930	COG2190	(PTS) system
A7J09_RS02930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7J09_RS02935	COG1940	carbohydrate kinase activity
A7J09_RS02950	COG0653	protein targeting
A7J09_RS02955	COG0736	holo-[acyl-carrier-protein] synthase activity
A7J09_RS02960	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A7J09_RS02965	COG0527	aspartate kinase activity
A7J09_RS02970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A7J09_RS02975	COG1024	Enoyl-CoA hydratase
A7J09_RS02985	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A7J09_RS03000	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A7J09_RS03005	COG1028	Short-chain dehydrogenase reductase Sdr
A7J09_RS03025	COG0439	Biotin carboxylase
A7J09_RS03050	COG1266	CAAX protease self-immunity
A7J09_RS03055	COG1266	CAAX protease self-immunity
A7J09_RS03070	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A7J09_RS03080	COG3177	Filamentation induced by cAMP protein fic
A7J09_RS03105	COG3716	PTS system mannose fructose sorbose family IID component
A7J09_RS03110	COG3715	PTS system
A7J09_RS03125	COG0561	phosphatase activity
A7J09_RS03130	COG2252	PERMEase
A7J09_RS03155	COG1104	cysteine desulfurase activity
A7J09_RS03160	COG0301	tRNA thio-modification
A7J09_RS03170	COG1114	Component of the transport system for branched-chain amino acids
A7J09_RS03175	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A7J09_RS03180	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A7J09_RS03200	COG0564	pseudouridine synthase activity
A7J09_RS03205	COG2824	Alkylphosphonate utilization operon protein PhnA
A7J09_RS03215	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A7J09_RS03220	COG0540	Belongs to the ATCase OTCase family
A7J09_RS03225	COG0505	Belongs to the CarA family
A7J09_RS03235	COG2521	methyltransferase
A7J09_RS03235	COG2136	Putative SAM-dependent methyltransferase
A7J09_RS03240	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
A7J09_RS03250	COG0228	four-way junction DNA binding
A7J09_RS03265	COG1132	(ABC) transporter
A7J09_RS03270	COG0726	polysaccharide deacetylase
A7J09_RS03275	COG0460	homoserine dehydrogenase
A7J09_RS03280	COG0083	homoserine kinase activity
A7J09_RS03285	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A7J09_RS03290	COG3842	ATPase activity
A7J09_RS03295	COG1176	ABC-type spermidine putrescine transport system, permease component I
A7J09_RS03300	COG1177	transmembrane transport
A7J09_RS03330	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A7J09_RS03340	COG0534	Mate efflux family protein
A7J09_RS03345	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A7J09_RS03350	COG0336	Belongs to the RNA methyltransferase TrmD family
A7J09_RS03355	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A7J09_RS03360	COG1349	DNA-binding transcription factor activity
A7J09_RS03365	COG1105	Belongs to the carbohydrate kinase PfkB family
A7J09_RS03370	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7J09_RS03370	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7J09_RS03370	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7J09_RS03380	COG3557	Belongs to the UPF0374 family
A7J09_RS03390	COG2188	Transcriptional regulator
A7J09_RS03395	COG2188	Transcriptional regulator
A7J09_RS03405	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7J09_RS03415	COG3716	PTS system mannose fructose sorbose family IID component
A7J09_RS03425	COG2017	converts alpha-aldose to the beta-anomer
A7J09_RS03440	COG0346	lactoylglutathione lyase activity
A7J09_RS03450	COG0525	valine-tRNA ligase activity
A7J09_RS03515	COG1217	gtp-binding protein TYPA
A7J09_RS03545	COG0681	Belongs to the peptidase S26 family
A7J09_RS03550	COG4886	Leucine-rich repeat (LRR) protein
A7J09_RS03575	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A7J09_RS03590	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A7J09_RS03595	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A7J09_RS03600	COG1799	cell septum assembly
A7J09_RS03615	COG3599	regulation of cell shape
A7J09_RS03645	COG4372	Transposase
A7J09_RS03655	COG0494	nUDIX hydrolase
A7J09_RS03655	COG0406	alpha-ribazole phosphatase activity
A7J09_RS03660	COG0542	response to heat
A7J09_RS03665	COG4703	Protein of unknown function (DUF1797)
A7J09_RS03670	COG0765	amino acid transport
A7J09_RS03680	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A7J09_RS03725	COG0789	Transcriptional regulator
A7J09_RS03740	COG0826	peptidase U32
A7J09_RS03755	COG4443	Transcriptional Coactivator p15 (PC4)
A7J09_RS03760	COG1268	BioY protein
A7J09_RS03770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A7J09_RS03775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7J09_RS03780	COG1136	(ABC) transporter
A7J09_RS03785	COG0577	efflux transmembrane transporter activity
A7J09_RS03795	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A7J09_RS03805	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A7J09_RS03815	COG3859	Proton-coupled thiamine transporter YuaJ
A7J09_RS03835	COG0772	Belongs to the SEDS family
A7J09_RS03840	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A7J09_RS03855	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A7J09_RS03865	COG3093	addiction module antidote protein HigA
A7J09_RS03875	COG0149	triose-phosphate isomerase activity
A7J09_RS03885	COG1078	dGTPase activity
A7J09_RS03925	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A7J09_RS03935	COG2884	Cell division ATP-binding protein ftsE
A7J09_RS03940	COG2177	Part of the ABC transporter FtsEX involved in
A7J09_RS03970	COG1132	(ABC) transporter
A7J09_RS03975	COG1132	(ABC) transporter
A7J09_RS03980	COG1011	Hydrolase
A7J09_RS03990	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
A7J09_RS04000	COG1737	Transcriptional regulator
A7J09_RS04010	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A7J09_RS04015	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A7J09_RS04020	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A7J09_RS04030	COG2814	Major facilitator Superfamily
A7J09_RS04035	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A7J09_RS04045	COG0017	Asparaginyl-tRNA synthetase
A7J09_RS04050	COG0557	exoribonuclease II activity
A7J09_RS04055	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A7J09_RS04060	COG1063	alcohol dehydrogenase
A7J09_RS04075	COG2217	Heavy metal translocating P-type atpase
A7J09_RS04080	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A7J09_RS04105	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A7J09_RS04105	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A7J09_RS04115	COG1832	CoA-binding protein
A7J09_RS04125	COG0343	queuine tRNA-ribosyltransferase activity
A7J09_RS04145	COG4470	Protein conserved in bacteria
A7J09_RS04165	COG0133	tryptophan synthase activity
A7J09_RS04170	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A7J09_RS04175	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A7J09_RS04185	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A7J09_RS04190	COG1119	ATPase activity
A7J09_RS04195	COG1253	flavin adenine dinucleotide binding
A7J09_RS04200	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A7J09_RS04205	COG1472	Belongs to the glycosyl hydrolase 3 family
A7J09_RS04230	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A7J09_RS04235	COG1733	regulation of RNA biosynthetic process
A7J09_RS04245	COG1227	inorganic diphosphatase activity
A7J09_RS04265	COG5433	transposase activity
A7J09_RS04280	COG0745	RESPONSE REGULATOR receiver
A7J09_RS04285	COG5002	protein histidine kinase activity
A7J09_RS04290	COG1755	Isoprenylcysteine carboxyl methyltransferase
A7J09_RS04310	COG2321	neutral zinc metallopeptidase
A7J09_RS04315	COG1570	exodeoxyribonuclease VII activity
A7J09_RS04320	COG1722	exodeoxyribonuclease VII activity
A7J09_RS04330	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A7J09_RS04335	COG1438	arginine binding
A7J09_RS04340	COG0497	DNA recombination
A7J09_RS04345	COG1307	EDD domain protein, DegV family
A7J09_RS04350	COG2755	lipolytic protein G-D-S-L family
A7J09_RS04360	COG0776	regulation of translation
A7J09_RS04385	COG3425	synthase
A7J09_RS04390	COG0183	Belongs to the thiolase family
A7J09_RS04425	COG0726	polysaccharide deacetylase
A7J09_RS04430	COG0513	Belongs to the DEAD box helicase family
A7J09_RS04435	COG0673	inositol 2-dehydrogenase activity
A7J09_RS04445	COG1695	Transcriptional regulator
A7J09_RS04455	COG1956	GAF domain-containing protein
A7J09_RS04460	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A7J09_RS04480	COG4372	Transposase
A7J09_RS04495	COG1363	Peptidase, m42
A7J09_RS04505	COG2131	deaminase
A7J09_RS04510	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A7J09_RS04515	COG2249	NAD(P)H dehydrogenase (quinone) activity
A7J09_RS04520	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A7J09_RS04530	COG0024	Methionine aminopeptidase
A7J09_RS04540	COG2246	polysaccharide biosynthetic process
A7J09_RS04545	COG4708	membrane
A7J09_RS04550	COG0656	L-ascorbic acid biosynthetic process
A7J09_RS04555	COG2183	response to ionizing radiation
A7J09_RS04560	COG3091	SprT-like family
A7J09_RS04575	COG1482	cell wall glycoprotein biosynthetic process
A7J09_RS04580	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A7J09_RS04585	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A7J09_RS04605	COG0517	IMP dehydrogenase activity
A7J09_RS04605	COG1125	glycine betaine transport
A7J09_RS04610	COG1174	glycine betaine transport
A7J09_RS04620	COG0436	Aminotransferase
A7J09_RS04630	COG0745	RESPONSE REGULATOR receiver
A7J09_RS04635	COG2205	protein histidine kinase activity
A7J09_RS04640	COG1136	(ABC) transporter
A7J09_RS04645	COG0577	efflux transmembrane transporter activity
A7J09_RS04675	COG1028	Short-chain dehydrogenase reductase Sdr
A7J09_RS04690	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A7J09_RS04695	COG0494	nUDIX hydrolase
A7J09_RS04735	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A7J09_RS04750	COG0513	Belongs to the DEAD box helicase family
A7J09_RS04755	COG0640	Transcriptional regulator
A7J09_RS04780	COG2827	Endonuclease containing a URI domain
A7J09_RS04785	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A7J09_RS04805	COG0626	cystathionine gamma-synthase activity
A7J09_RS04810	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A7J09_RS04815	COG2207	Transcriptional regulator
A7J09_RS04825	COG1653	transport
A7J09_RS04830	COG1175	transmembrane transport
A7J09_RS04835	COG0395	ABC-type sugar transport system, permease component
A7J09_RS04845	COG0366	Alpha amylase catalytic
A7J09_RS04850	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A7J09_RS04865	COG5433	transposase activity
A7J09_RS04875	COG0683	leucine binding
A7J09_RS04910	COG1466	dna polymerase III delta subunit
A7J09_RS04915	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A7J09_RS04920	COG0737	Belongs to the 5'-nucleotidase family
A7J09_RS04925	COG5433	transposase activity
A7J09_RS04935	COG0038	chloride channel
A7J09_RS04940	COG0287	Prephenate dehydrogenase
A7J09_RS04940	COG1605	Chorismate mutase
A7J09_RS04950	COG0716	FMN binding
A7J09_RS04955	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A7J09_RS04995	COG0772	Belongs to the SEDS family
A7J09_RS05000	COG0693	protein deglycase activity
A7J09_RS05005	COG0187	DNA topoisomerase II activity
A7J09_RS05010	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
A7J09_RS05015	COG0560	Phosphoserine phosphatase
A7J09_RS05030	COG4372	Transposase
A7J09_RS05065	COG1929	Belongs to the glycerate kinase type-1 family
A7J09_RS05105	COG1011	Hydrolase
A7J09_RS05115	COG2706	6-phosphogluconolactonase activity
A7J09_RS05120	COG0628	permease
A7J09_RS05130	COG3527	Alpha-acetolactate decarboxylase
A7J09_RS05140	COG1293	RNA-binding protein homologous to eukaryotic snRNP
A7J09_RS05155	COG3842	ATPase activity
A7J09_RS05160	COG1442	glycosyl transferase family 8
A7J09_RS05160	COG1216	Glycosyl transferase, family 2
A7J09_RS05210	COG1216	Glycosyl transferase, family 2
A7J09_RS05210	COG1442	glycosyl transferase family 8
A7J09_RS05220	COG1442	glycosyl transferase family 8
A7J09_RS05220	COG1216	Glycosyl transferase, family 2
A7J09_RS05230	COG1215	transferase activity, transferring glycosyl groups
A7J09_RS05235	COG1215	transferase activity, transferring glycosyl groups
A7J09_RS05245	COG5433	transposase activity
A7J09_RS05250	COG0201	protein transport
A7J09_RS05315	COG4372	Transposase
A7J09_RS05320	COG0488	(ABC) transporter
A7J09_RS05335	COG2226	methyltransferase
A7J09_RS05340	COG3442	glutamine amidotransferase
A7J09_RS05345	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A7J09_RS05360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A7J09_RS05365	COG0488	(ABC) transporter
A7J09_RS05390	COG1573	uracil-dna glycosylase
A7J09_RS05400	COG1704	LemA family
A7J09_RS05410	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A7J09_RS05420	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A7J09_RS05425	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A7J09_RS05435	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A7J09_RS05440	COG0813	purine-nucleoside phosphorylase activity
A7J09_RS05445	COG0058	SHG alpha-glucan phosphorylase activity
A7J09_RS05455	COG1724	mRNA binding
A7J09_RS05465	COG0582	viral genome integration into host DNA
A7J09_RS05475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A7J09_RS05490	COG0647	UMP catabolic process
A7J09_RS05500	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A7J09_RS05505	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A7J09_RS05510	COG1970	mechanosensitive ion channel activity
A7J09_RS05515	COG0358	DNA primase activity
A7J09_RS05520	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A7J09_RS05525	COG2151	metal-sulfur cluster biosynthetic enzyme
A7J09_RS05560	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A7J09_RS05570	COG1131	(ABC) transporter
A7J09_RS05575	COG2188	Transcriptional regulator
A7J09_RS05585	COG0205	6-phosphofructokinase activity
A7J09_RS05590	COG0469	pyruvate kinase activity
A7J09_RS05600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7J09_RS05605	COG0657	acetylesterase activity
A7J09_RS05605	COG2755	lipolytic protein G-D-S-L family
A7J09_RS05615	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A7J09_RS05620	COG2213	PTS system mannitol-specific
A7J09_RS05625	COG3711	transcriptional antiterminator
A7J09_RS05630	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7J09_RS05635	COG0246	Mannitol dehydrogenase
A7J09_RS05640	COG0765	amino acid transport
A7J09_RS05645	COG1126	abc transporter atp-binding protein
A7J09_RS05650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7J09_RS05655	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A7J09_RS05665	COG3583	domain protein
A7J09_RS05665	COG3583	domain protein
A7J09_RS05675	COG1307	EDD domain protein, DegV family
A7J09_RS05680	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A7J09_RS05685	COG0617	tRNA 3'-terminal CCA addition
A7J09_RS05690	COG0488	(ABC) transporter
A7J09_RS05700	COG1940	carbohydrate kinase activity
A7J09_RS05715	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A7J09_RS05720	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A7J09_RS05730	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A7J09_RS05750	COG4372	Transposase
A7J09_RS05770	COG4372	Transposase
A7J09_RS05810	COG1466	dna polymerase III delta subunit
A7J09_RS05815	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A7J09_RS05840	COG0481	GTPase activity
A7J09_RS05865	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A7J09_RS05870	COG2890	protein-(glutamine-N5) methyltransferase activity
A7J09_RS05875	COG0009	L-threonylcarbamoyladenylate synthase
A7J09_RS05885	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A7J09_RS05895	COG0741	lytic transglycosylase activity
A7J09_RS05900	COG4221	oxidoreductase activity
A7J09_RS05930	COG1401	restriction endodeoxyribonuclease activity
A7J09_RS05935	COG4268	DNA restriction-modification system
A7J09_RS05945	COG2188	Transcriptional regulator
A7J09_RS05950	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
A7J09_RS05955	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A7J09_RS05970	COG1660	Displays ATPase and GTPase activities
A7J09_RS05975	COG4974	Belongs to the 'phage' integrase family
A7J09_RS05990	COG0745	RESPONSE REGULATOR receiver
A7J09_RS06010	COG1136	(ABC) transporter
A7J09_RS06050	COG2382	esterase
A7J09_RS06065	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A7J09_RS06100	COG1396	sequence-specific DNA binding
A7J09_RS06105	COG1181	Belongs to the D-alanine--D-alanine ligase family
A7J09_RS06145	COG3843	relaxase mobilization nuclease domain protein
A7J09_RS06165	COG0542	response to heat
A7J09_RS06175	COG0542	response to heat
A7J09_RS06180	COG1396	sequence-specific DNA binding
A7J09_RS06270	COG4443	Transcriptional Coactivator p15 (PC4)
A7J09_RS06275	COG1475	DNA binding
A7J09_RS06420	COG0270	DNA (cytosine-5-)-methyltransferase activity
A7J09_RS06435	COG0222	ribosome binding
A7J09_RS06440	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A7J09_RS06445	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A7J09_RS06450	COG0758	DNA mediated transformation
A7J09_RS06455	COG0110	maltose O-acetyltransferase activity
A7J09_RS06460	COG0425	Belongs to the sulfur carrier protein TusA family
A7J09_RS06460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7J09_RS06470	COG1272	protein, Hemolysin III
A7J09_RS06480	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A7J09_RS06485	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A7J09_RS06490	COG0582	viral genome integration into host DNA
A7J09_RS06500	COG1396	sequence-specific DNA binding
A7J09_RS06505	COG4372	Transposase
A7J09_RS06530	COG1940	carbohydrate kinase activity
A7J09_RS06550	COG1175	transmembrane transport
A7J09_RS06570	COG4806	L-rhamnose isomerase
A7J09_RS06570	COG1070	Carbohydrate kinase
A7J09_RS06645	COG1263	PTS System
A7J09_RS06645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7J09_RS06645	COG2190	(PTS) system
A7J09_RS06720	COG3942	CHAP domain
A7J09_RS06720	COG1705	Flagellar rod assembly protein muramidase FlgJ
A7J09_RS06780	COG0424	maF-like protein
A7J09_RS06785	COG0737	Belongs to the 5'-nucleotidase family
A7J09_RS06795	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A7J09_RS06800	COG0463	Glycosyl transferase, family 2
A7J09_RS06810	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A7J09_RS06815	COG0284	orotidine-5'-phosphate decarboxylase activity
A7J09_RS06820	COG0167	dihydroorotate dehydrogenase activity
A7J09_RS06845	COG0297	glycogen (starch) synthase activity
A7J09_RS06865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7J09_RS06880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7J09_RS06925	COG3583	domain protein
A7J09_RS06940	COG1126	abc transporter atp-binding protein
A7J09_RS06950	COG0488	(ABC) transporter
A7J09_RS06955	COG2873	o-acetylhomoserine
A7J09_RS06980	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A7J09_RS06980	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A7J09_RS06990	COG3711	transcriptional antiterminator
A7J09_RS06995	COG3684	Belongs to the aldolase LacD family
A7J09_RS07000	COG1105	Belongs to the carbohydrate kinase PfkB family
A7J09_RS07005	COG0698	ribose 5-phosphate isomerase
A7J09_RS07010	COG0698	ribose 5-phosphate isomerase
A7J09_RS07020	COG1349	DNA-binding transcription factor activity
A7J09_RS07065	COG1194	a g-specific adenine glycosylase
A7J09_RS07075	COG1132	(ABC) transporter
A7J09_RS07080	COG1132	(ABC) transporter
A7J09_RS07095	COG0280	phosphate acetyltransferase
A7J09_RS07100	COG0564	pseudouridine synthase activity
A7J09_RS07105	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A7J09_RS07110	COG2357	RelA SpoT domain protein
A7J09_RS07115	COG4116	CYTH
A7J09_RS07125	COG1104	cysteine desulfurase activity
A7J09_RS07140	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A7J09_RS07145	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A7J09_RS07155	COG3764	Sortase (surface protein transpeptidase)
A7J09_RS07160	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A7J09_RS07165	COG0039	L-malate dehydrogenase activity
A7J09_RS07175	COG1079	Belongs to the binding-protein-dependent transport system permease family
A7J09_RS07180	COG4603	Belongs to the binding-protein-dependent transport system permease family
A7J09_RS07185	COG3845	ABC transporter
A7J09_RS07190	COG1744	ABC transporter substrate-binding protein PnrA-like
A7J09_RS07195	COG0295	cytidine deaminase activity
A7J09_RS07205	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A7J09_RS07210	COG2813	Specifically methylates the guanine in position
A7J09_RS07215	COG1072	(Pantothenic acid kinase))
A7J09_RS07240	COG5002	protein histidine kinase activity
A7J09_RS07245	COG0745	RESPONSE REGULATOR receiver
A7J09_RS07255	COG0704	Plays a role in the regulation of phosphate uptake
A7J09_RS07260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A7J09_RS07265	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A7J09_RS07270	COG0581	inorganic phosphate transmembrane transporter activity
A7J09_RS07275	COG0573	inorganic phosphate transmembrane transporter activity
A7J09_RS07285	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A7J09_RS07285	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A7J09_RS07290	COG0483	inositol monophosphate 1-phosphatase activity
A7J09_RS07295	COG4476	Belongs to the UPF0223 family
A7J09_RS07300	COG1393	Belongs to the ArsC family
A7J09_RS07305	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A7J09_RS07310	COG0196	riboflavin kinase activity
A7J09_RS07315	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A7J09_RS07360	COG0561	phosphatase activity
A7J09_RS07365	COG2195	Cleaves the N-terminal amino acid of tripeptides
A7J09_RS07380	COG1695	Transcriptional regulator
A7J09_RS07400	COG3759	membrane
A7J09_RS07405	COG1846	Transcriptional regulator
A7J09_RS07420	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A7J09_RS07430	COG2610	gluconate transmembrane transporter activity
A7J09_RS07450	COG0302	gtp cyclohydrolase
A7J09_RS07455	COG1051	belongs to the nudix hydrolase family
A7J09_RS07515	COG1028	Short-chain dehydrogenase reductase Sdr
A7J09_RS07520	COG1312	Catalyzes the dehydration of D-mannonate
A7J09_RS07530	COG0800	Aldolase
A7J09_RS07540	COG3250	beta-galactosidase activity
A7J09_RS07550	COG2211	Major facilitator Superfamily
A7J09_RS07575	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A7J09_RS07580	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A7J09_RS07585	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A7J09_RS07590	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A7J09_RS07595	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A7J09_RS07600	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A7J09_RS07605	COG0356	it plays a direct role in the translocation of protons across the membrane
A7J09_RS07615	COG1597	lipid kinase activity
A7J09_RS07625	COG0701	Predicted permease
A7J09_RS07630	COG3689	TIGRFAM TIGR03943 family protein
A7J09_RS07635	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A7J09_RS07645	COG0552	protein localization to endoplasmic reticulum
A7J09_RS07650	COG0561	phosphatase activity
A7J09_RS07655	COG0561	phosphatase activity
A7J09_RS07660	COG1196	nuclear chromosome segregation
A7J09_RS07700	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7J09_RS07705	COG0538	isocitrate dehydrogenase activity
A7J09_RS07710	COG0372	Belongs to the citrate synthase family
A7J09_RS07715	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A7J09_RS07720	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A7J09_RS07725	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A7J09_RS07730	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A7J09_RS07760	COG1476	TRANSCRIPTIONal
A7J09_RS07780	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A7J09_RS07790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A7J09_RS07795	COG4122	O-methyltransferase activity
A7J09_RS07820	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A7J09_RS07820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A7J09_RS07835	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A7J09_RS07840	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A7J09_RS07850	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A7J09_RS07880	COG4372	Transposase
A7J09_RS07885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7J09_RS07885	COG1116	anion transmembrane transporter activity
A7J09_RS07890	COG4120	Belongs to the binding-protein-dependent transport system permease family
A7J09_RS07905	COG3684	Belongs to the aldolase LacD family
A7J09_RS07915	COG3679	Belongs to the UPF0342 family
A7J09_RS07920	COG0287	Prephenate dehydrogenase
A7J09_RS07925	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A7J09_RS07930	COG0710	3-dehydroquinate dehydratase activity
A7J09_RS07935	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A7J09_RS07940	COG1368	sulfuric ester hydrolase activity
A7J09_RS07955	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A7J09_RS07965	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A7J09_RS08000	COG1216	Glycosyl transferase, family 2
A7J09_RS08015	COG1442	glycosyl transferase family 8
A7J09_RS08015	COG1216	Glycosyl transferase, family 2
A7J09_RS08020	COG1442	glycosyl transferase family 8
A7J09_RS08050	COG1216	Glycosyl transferase, family 2
A7J09_RS08050	COG1442	glycosyl transferase family 8
A7J09_RS08085	COG1091	dTDP-4-dehydrorhamnose reductase activity
A7J09_RS08090	COG1088	dTDP-glucose 4,6-dehydratase activity
A7J09_RS08105	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A7J09_RS08125	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A7J09_RS08130	COG2384	SAM-dependent methyltransferase
A7J09_RS08145	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A7J09_RS08155	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A7J09_RS08155	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A7J09_RS08160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A7J09_RS08170	COG0300	oxidoreductase activity
A7J09_RS08175	COG1234	tRNA 3'-trailer cleavage
A7J09_RS08185	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A7J09_RS08190	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A7J09_RS08210	COG2807	transmembrane transport
A7J09_RS08215	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A7J09_RS08220	COG1702	phosphate starvation-inducible protein PhoH
A7J09_RS08225	COG4479	Belongs to the UPF0346 family
A7J09_RS08240	COG2996	Protein conserved in bacteria
A7J09_RS08245	COG0233	cytoplasmic translational termination
A7J09_RS08250	COG0528	UMP kinase activity
A7J09_RS08255	COG2244	polysaccharide biosynthetic process
A7J09_RS08265	COG0625	glutathione transferase activity
A7J09_RS08295	COG0346	lactoylglutathione lyase activity
A7J09_RS08300	COG0697	spore germination
A7J09_RS08300	COG1674	ftsk spoiiie
A7J09_RS08305	COG1621	beta-fructofuranosidase activity
A7J09_RS08310	COG1653	transport
A7J09_RS08315	COG0395	ABC-type sugar transport system, permease component
A7J09_RS08320	COG4209	transmembrane transport
A7J09_RS08325	COG1609	Transcriptional regulator
A7J09_RS08345	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A7J09_RS08355	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A7J09_RS08365	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A7J09_RS08375	COG1181	Belongs to the D-alanine--D-alanine ligase family
A7J09_RS08380	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A7J09_RS08385	COG0768	penicillin binding
A7J09_RS08390	COG0488	(ABC) transporter
A7J09_RS08405	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A7J09_RS08415	COG0745	RESPONSE REGULATOR receiver
A7J09_RS08425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7J09_RS08430	COG0765	amino acid transport
A7J09_RS08435	COG0765	amino acid transport
A7J09_RS08450	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A7J09_RS08465	COG0438	transferase activity, transferring glycosyl groups
A7J09_RS08480	COG1609	Transcriptional regulator
A7J09_RS08495	COG3716	PTS system mannose fructose sorbose family IID component
A7J09_RS08500	COG3715	PTS system
A7J09_RS08505	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7J09_RS08520	COG1070	Carbohydrate kinase
A7J09_RS08525	COG2115	Belongs to the xylose isomerase family
A7J09_RS08535	COG1940	carbohydrate kinase activity
A7J09_RS08550	COG3480	Lon protease (S16) C-terminal proteolytic domain
A7J09_RS08555	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A7J09_RS08560	COG0742	ribosomal rna small subunit methyltransferase
A7J09_RS08570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7J09_RS08575	COG4483	Protein conserved in bacteria
A7J09_RS08585	COG2197	response regulator
A7J09_RS08590	COG4585	Histidine kinase
A7J09_RS08595	COG0842	Transport permease protein
A7J09_RS08600	COG1131	(ABC) transporter
A7J09_RS08615	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A7J09_RS08630	COG0671	phosphoesterase, PA-phosphatase related
A7J09_RS08635	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A7J09_RS08655	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A7J09_RS08660	COG1187	pseudouridine synthase activity
A7J09_RS08665	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A7J09_RS08670	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A7J09_RS08675	COG0582	viral genome integration into host DNA
A7J09_RS08695	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A7J09_RS08700	COG3763	UPF0154 protein
A7J09_RS08710	COG3579	cysteine-type endopeptidase activity
A7J09_RS08725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A7J09_RS08730	COG1254	Belongs to the acylphosphatase family
A7J09_RS08735	COG0706	membrane insertase activity
A7J09_RS08740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A7J09_RS08745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A7J09_RS08755	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A7J09_RS08765	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A7J09_RS08785	COG1160	GTP binding
A7J09_RS08795	COG1484	DNA-dependent DNA replication
A7J09_RS08805	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A7J09_RS08810	COG0628	permease
A7J09_RS08815	COG0745	RESPONSE REGULATOR receiver
A7J09_RS08820	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A7J09_RS08830	COG0492	ferredoxin-NADP+ reductase activity
A7J09_RS08840	COG0513	Belongs to the DEAD box helicase family
A7J09_RS08850	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A7J09_RS08855	COG0768	penicillin binding
A7J09_RS08865	COG0275	rRNA processing
A7J09_RS08915	COG4939	FMN-binding domain protein
A7J09_RS08920	COG0142	geranyltranstransferase activity
A7J09_RS08925	COG1252	NADH dehydrogenase
A7J09_RS08940	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A7J09_RS08945	COG0569	domain protein
A7J09_RS08950	COG0534	Mate efflux family protein
A7J09_RS08970	COG4224	UPF0291 protein
A7J09_RS08980	COG0751	glycine-tRNA ligase activity
A7J09_RS09005	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A7J09_RS09010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7J09_RS09015	COG1464	Belongs to the NlpA lipoprotein family
A7J09_RS09020	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A7J09_RS09025	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A7J09_RS09030	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A7J09_RS09045	COG0539	negative regulation of cytoplasmic translation
A7J09_RS09065	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A7J09_RS09075	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A7J09_RS09105	COG2184	nucleotidyltransferase activity
A7J09_RS09110	COG0187	DNA topoisomerase II activity
A7J09_RS09120	COG1074	ATP-dependent DNA helicase activity
A7J09_RS09125	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A7J09_RS09170	COG1131	(ABC) transporter
A7J09_RS09195	COG4372	Transposase
A7J09_RS09220	COG1011	Hydrolase
A7J09_RS09225	COG1122	ATPase activity
A7J09_RS09230	COG1122	ATPase activity
A7J09_RS09245	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
A7J09_RS09265	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A7J09_RS09280	COG0210	DNA helicase
A7J09_RS09315	COG1164	Oligoendopeptidase f
A7J09_RS09330	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A7J09_RS09335	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A7J09_RS09340	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A7J09_RS09350	COG0446	pyridine nucleotide-disulphide oxidoreductase
A7J09_RS09360	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A7J09_RS09430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A7J09_RS09445	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A7J09_RS09455	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A7J09_RS09460	COG4684	Psort location CytoplasmicMembrane, score
A7J09_RS09465	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A7J09_RS09525	COG0531	amino acid
A7J09_RS09535	COG0708	Exodeoxyribonuclease III
A7J09_RS09550	COG1393	Belongs to the ArsC family
A7J09_RS09555	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A7J09_RS09560	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A7J09_RS09570	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A7J09_RS09580	COG4467	Involved in initiation control of chromosome replication
A7J09_RS09585	COG0470	DNA polymerase III
A7J09_RS09590	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A7J09_RS09595	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A7J09_RS09615	COG0517	IMP dehydrogenase activity
A7J09_RS09620	COG2333	competence protein COMEC
A7J09_RS09620	COG0658	competence protein
A7J09_RS09625	COG1596	polysaccharide export
A7J09_RS09625	COG1555	photosystem II stabilization
A7J09_RS09630	COG0204	Acyl-transferase
A7J09_RS09635	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A7J09_RS09640	COG1120	ATPase activity
A7J09_RS09645	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A7J09_RS09660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7J09_RS09665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7J09_RS09675	COG0386	Belongs to the glutathione peroxidase family
A7J09_RS09680	COG1187	pseudouridine synthase activity
A7J09_RS09685	COG0435	Glutathione S-transferase
A7J09_RS09690	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A7J09_RS09710	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A7J09_RS09715	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A7J09_RS09720	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A7J09_RS09730	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A7J09_RS09735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7J09_RS09740	COG1696	Membrane protein involved in D-alanine export
A7J09_RS09745	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A7J09_RS09785	COG0363	glucosamine-6-phosphate deaminase activity
A7J09_RS09790	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A7J09_RS09795	COG1438	arginine binding
A7J09_RS09800	COG3583	domain protein
A7J09_RS09800	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A7J09_RS09800	COG3064	Membrane
A7J09_RS09805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7J09_RS09810	COG1288	antiporter activity
A7J09_RS09815	COG0549	Belongs to the carbamate kinase family
A7J09_RS09820	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A7J09_RS09825	COG0454	-acetyltransferase
A7J09_RS09845	COG1481	regulation of sporulation
A7J09_RS09850	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A7J09_RS09855	COG1660	Displays ATPase and GTPase activities
A7J09_RS09860	COG0251	oxidation-reduction process
A7J09_RS09885	COG0436	Aminotransferase
A7J09_RS09900	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A7J09_RS09905	COG0562	UDP-galactopyranose mutase
A7J09_RS09915	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A7J09_RS09925	COG0077	Prephenate dehydratase
A7J09_RS09930	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A7J09_RS09940	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A7J09_RS09950	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A7J09_RS09975	COG4372	Transposase
A7J09_RS09985	COG4372	Transposase
A7J09_RS10005	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A7J09_RS10025	COG0438	transferase activity, transferring glycosyl groups
A7J09_RS10035	COG1045	serine acetyltransferase
A7J09_RS10045	COG0438	transferase activity, transferring glycosyl groups
A7J09_RS10050	COG0438	transferase activity, transferring glycosyl groups
A7J09_RS10060	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A7J09_RS10065	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A7J09_RS10070	COG3177	Filamentation induced by cAMP protein fic
A7J09_RS10080	COG4464	protein tyrosine phosphatase activity
A7J09_RS10090	COG3944	biosynthesis protein
A7J09_RS10095	COG1316	TRANSCRIPTIONal
A7J09_RS10100	COG3022	response to hydroperoxide
A7J09_RS10105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7J09_RS10115	COG1307	EDD domain protein, DegV family
A7J09_RS10135	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A7J09_RS10140	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A7J09_RS10145	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A7J09_RS10150	COG2176	DNA-directed DNA polymerase activity
A7J09_RS10175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7J09_RS10180	COG1126	abc transporter atp-binding protein
A7J09_RS10185	COG0765	amino acid transport
A7J09_RS10195	COG2137	regulation of response to DNA damage stimulus
A7J09_RS10200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A7J09_RS10290	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A7J09_RS10295	COG1739	Uncharacterized protein family UPF0029
A7J09_RS10305	COG1098	S1 RNA binding domain
A7J09_RS10330	COG2815	serine threonine protein kinase
A7J09_RS10330	COG0515	serine threonine protein kinase
A7J09_RS10335	COG0631	protein serine/threonine phosphatase activity
A7J09_RS10340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A7J09_RS10340	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A7J09_RS10345	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A7J09_RS10355	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A7J09_RS10360	COG1758	RNA polymerase activity
A7J09_RS10370	COG1418	mRNA catabolic process
A7J09_RS10375	COG1854	S-ribosylhomocysteine lyase activity
A7J09_RS10395	COG0116	Belongs to the methyltransferase superfamily
A7J09_RS10405	COG3599	regulation of cell shape
A7J09_RS10410	COG4474	Belongs to the UPF0398 family
A7J09_RS10415	COG3331	DNA recombination
A7J09_RS10420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A7J09_RS10425	COG0357	Ribosomal RNA small subunit methyltransferase G
A7J09_RS10440	COG1122	ATPase activity
A7J09_RS10460	COG1115	amino acid carrier protein
A7J09_RS10485	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A7J09_RS10485	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A7J09_RS10495	COG3118	belongs to the thioredoxin family
A7J09_RS10505	COG1193	negative regulation of DNA recombination
A7J09_RS10520	COG2188	Transcriptional regulator
A7J09_RS10530	COG0366	Alpha amylase catalytic
A7J09_RS10555	COG0681	Belongs to the peptidase S26 family
A7J09_RS10560	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A7J09_RS10565	COG2217	Heavy metal translocating P-type atpase
A7J09_RS10575	COG2217	Heavy metal translocating P-type atpase
A7J09_RS10580	COG0363	glucosamine-6-phosphate deaminase activity
A7J09_RS10615	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A7J09_RS10640	COG2910	NAD(P)H-binding
A7J09_RS10655	COG1882	Formate acetyltransferase
A7J09_RS10670	COG3177	Filamentation induced by cAMP protein fic
A7J09_RS10690	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
A7J09_RS10695	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A7J09_RS10730	COG2222	sugar isomerase
A7J09_RS10735	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A7J09_RS10740	COG0584	glycerophosphoryl diester phosphodiesterase
A7J09_RS10765	COG3959	Transketolase, thiamine diphosphate binding domain
A7J09_RS10780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7J09_RS10790	COG2723	6-phospho-beta-galactosidase activity
A7J09_RS10795	COG2081	HI0933 family
A7J09_RS10800	COG1131	(ABC) transporter
A7J09_RS10810	COG4372	Transposase
A7J09_RS10845	COG2855	membrane
A7J09_RS10870	COG0395	ABC-type sugar transport system, permease component
A7J09_RS10875	COG1175	transmembrane transport
A7J09_RS10890	COG2207	Transcriptional regulator
A7J09_RS10895	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A7J09_RS10905	COG1214	PFAM Peptidase M22, glycoprotease
A7J09_RS10930	COG0174	glutamine synthetase
A7J09_RS10935	COG0789	Transcriptional regulator
A7J09_RS10945	COG0126	phosphoglycerate kinase activity
A7J09_RS10955	COG3590	peptidase
A7J09_RS10960	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A7J09_RS10965	COG0049	tRNA binding
A7J09_RS10980	COG0459	protein refolding
A7J09_RS11010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A7J09_RS11020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A7J09_RS11030	COG1363	Peptidase, m42
A7J09_RS11035	COG0285	dihydrofolate synthase activity
A7J09_RS11045	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A7J09_RS11075	COG4537	Required for transformation and DNA binding
A7J09_RS11080	COG1459	type II secretion system
A7J09_RS11085	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A7J09_RS11090	COG1619	proteins homologs of microcin C7 resistance protein MccF
A7J09_RS11100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A7J09_RS11105	COG0085	RNA polymerase activity
A7J09_RS11110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A7J09_RS11145	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A7J09_RS11150	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A7J09_RS11170	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A7J09_RS11175	COG0542	response to heat
A7J09_RS11180	COG4463	regulation of RNA biosynthetic process
A7J09_RS11190	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A7J09_RS11330	COG0582	viral genome integration into host DNA
A7J09_RS11420	COG1396	sequence-specific DNA binding
A7J09_RS11445	COG0582	viral genome integration into host DNA
A7J09_RS11465	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A7J09_RS11470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A7J09_RS11475	COG0492	ferredoxin-NADP+ reductase activity
A7J09_RS11480	COG0564	pseudouridine synthase activity
A7J09_RS11530	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A7J09_RS11550	COG1564	THIamine pyrophosphokinase
A7J09_RS11560	COG1162	GTPase activity
A7J09_RS11570	COG1132	(ABC) transporter
A7J09_RS11595	COG4115	mRNA cleavage
A7J09_RS11615	COG3290	protein histidine kinase activity
A7J09_RS11635	COG3843	relaxase mobilization nuclease domain protein
A7J09_RS11810	COG1511	domain protein
A7J09_RS11815	COG1309	transcriptional regulator
A7J09_RS11820	COG1131	(ABC) transporter
A7J09_RS11835	COG0561	phosphatase activity
A7J09_RS11870	COG2843	Capsule synthesis protein
A7J09_RS11875	COG0167	dihydroorotate dehydrogenase activity
A7J09_RS11885	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A7J09_RS11900	COG0668	transmembrane transport
A7J09_RS11910	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A7J09_RS11920	COG1447	Phosphotransferase system cellobiose-specific component IIA
A7J09_RS11930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7J09_RS11930	COG3711	transcriptional antiterminator
A7J09_RS11940	COG2723	6-phospho-beta-galactosidase activity
A7J09_RS11945	COG1486	melibiose metabolic process
A7J09_RS11960	COG3590	peptidase
A7J09_RS11970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A7J09_RS11975	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A7J09_RS11975	COG1321	iron dependent repressor
A7J09_RS11980	COG1121	(ABC) transporter
A7J09_RS11995	COG0803	Belongs to the bacterial solute-binding protein 9 family
A7J09_RS12015	COG1490	D-aminoacyl-tRNA deacylase activity
A7J09_RS12025	COG0737	Belongs to the 5'-nucleotidase family
A7J09_RS12040	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A7J09_RS12060	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A7J09_RS12090	COG0737	Belongs to the 5'-nucleotidase family
A7J09_RS12100	COG1328	CTP reductase activity
A7J09_RS12105	COG1126	abc transporter atp-binding protein
A7J09_RS12115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7J09_RS12120	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A7J09_RS12140	COG1438	arginine binding
A7J09_RS12145	COG0018	arginyl-trna synthetase
A7J09_RS12165	COG1640	4-alpha-glucanotransferase
A7J09_RS12170	COG2182	Extracellular solute-binding protein
A7J09_RS12175	COG1175	transmembrane transport
A7J09_RS12180	COG3833	ABC-type maltose transport systems, permease component
A7J09_RS12185	COG5521	maltodextrose utilization protein MalA
A7J09_RS12190	COG1609	Transcriptional regulator
A7J09_RS12195	COG1523	belongs to the glycosyl hydrolase 13 family
A7J09_RS12205	COG1780	Probably involved in ribonucleotide reductase function
A7J09_RS12210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A7J09_RS12215	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A7J09_RS12220	COG2153	protein acetylation
A7J09_RS12225	COG4989	oxidoreductase activity
A7J09_RS12235	COG1472	Belongs to the glycosyl hydrolase 3 family
A7J09_RS12275	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A7J09_RS12285	COG0305	Participates in initiation and elongation during chromosome replication
A7J09_RS12290	COG0359	binds to the 23S rRNA
A7J09_RS12300	COG0445	tRNA wobble uridine modification
A7J09_RS12310	COG1733	regulation of RNA biosynthetic process
A7J09_RS12320	COG0482	sulfurtransferase activity
A7J09_RS12325	COG1760	l-serine dehydratase
A7J09_RS12330	COG1760	l-serine dehydratase
A7J09_RS12345	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A7J09_RS12350	COG1122	ATPase activity
A7J09_RS12355	COG1122	ATPase activity
A7J09_RS12360	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A7J09_RS12365	COG1426	Protein conserved in bacteria
A7J09_RS12370	COG0612	Peptidase, M16
A7J09_RS12375	COG0612	Peptidase, M16
A7J09_RS12445	COG0582	viral genome integration into host DNA
A7J09_RS12455	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A7J09_RS12460	COG0516	GMP reductase activity
A7J09_RS12460	COG0517	IMP dehydrogenase activity
A7J09_RS12470	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A7J09_RS12475	COG0488	(ABC) transporter
A7J09_RS12515	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A7J09_RS12520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A7J09_RS12525	COG1475	DNA binding