locus-tag	class	description
L3X15_RS00005	COG0592	DNA-directed DNA polymerase activity
L3X15_RS00025	COG0012	GTP binding
L3X15_RS00030	COG0193	aminoacyl-tRNA hydrolase activity
L3X15_RS00035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L3X15_RS00040	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L3X15_RS00055	COG0037	tRNA processing
L3X15_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L3X15_RS00175	COG1792	Involved in formation and maintenance of cell shape
L3X15_RS00190	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L3X15_RS00195	COG0436	Aminotransferase
L3X15_RS00200	COG1381	Involved in DNA repair and RecF pathway recombination
L3X15_RS00205	COG0416	fatty acid biosynthetic process
L3X15_RS00210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L3X15_RS00220	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L3X15_RS00235	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L3X15_RS00240	COG0138	bifunctional purine biosynthesis protein purh
L3X15_RS00245	COG0151	Belongs to the GarS family
L3X15_RS00250	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
L3X15_RS00270	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L3X15_RS00290	COG1131	(ABC) transporter
L3X15_RS00300	COG1132	(ABC) transporter
L3X15_RS00310	COG2255	four-way junction helicase activity
L3X15_RS00320	COG0546	phosphoglycolate phosphatase activity
L3X15_RS00340	COG0285	dihydrofolate synthase activity
L3X15_RS00350	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L3X15_RS00355	COG0632	four-way junction helicase activity
L3X15_RS00360	COG0519	Catalyzes the synthesis of GMP from XMP
L3X15_RS00375	COG1393	Belongs to the ArsC family
L3X15_RS00380	COG4472	Bacterial protein of unknown function (DUF965)
L3X15_RS00385	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L3X15_RS00390	COG3906	Belongs to the UPF0473 family
L3X15_RS00410	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
L3X15_RS00415	COG0088	Forms part of the polypeptide exit tunnel
L3X15_RS00420	COG0089	rRNA binding
L3X15_RS00425	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
L3X15_RS00430	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
L3X15_RS00435	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
L3X15_RS00440	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
L3X15_RS00445	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
L3X15_RS00450	COG0255	Belongs to the universal ribosomal protein uL29 family
L3X15_RS00455	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
L3X15_RS00460	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
L3X15_RS00465	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
L3X15_RS00470	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
L3X15_RS00475	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
L3X15_RS00480	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
L3X15_RS00485	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
L3X15_RS00490	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
L3X15_RS00495	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
L3X15_RS00500	COG1841	ribosomal large subunit assembly
L3X15_RS00510	COG0201	protein transport
L3X15_RS00515	COG0563	adenylate kinase activity
L3X15_RS00520	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
L3X15_RS00525	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L3X15_RS00530	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
L3X15_RS00540	COG0202	RNA polymerase activity
L3X15_RS00630	COG0582	viral genome integration into host DNA
L3X15_RS00640	COG2946	Replication initiation factor
L3X15_RS00675	COG0582	viral genome integration into host DNA
L3X15_RS00690	COG1121	(ABC) transporter
L3X15_RS00695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L3X15_RS00700	COG0803	Belongs to the bacterial solute-binding protein 9 family
L3X15_RS00700	COG3443	Belongs to the bacterial solute-binding protein 9 family
L3X15_RS00725	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L3X15_RS00730	COG0085	RNA polymerase activity
L3X15_RS00735	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
L3X15_RS00750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L3X15_RS00755	COG1459	type II secretion system
L3X15_RS00760	COG4537	Required for transformation and DNA binding
L3X15_RS00790	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L3X15_RS00800	COG0285	dihydrofolate synthase activity
L3X15_RS00805	COG1363	Peptidase, m42
L3X15_RS00815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L3X15_RS00825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L3X15_RS00850	COG0459	protein refolding
L3X15_RS00860	COG0049	tRNA binding
L3X15_RS00865	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L3X15_RS00870	COG3590	peptidase
L3X15_RS00880	COG0126	phosphoglycerate kinase activity
L3X15_RS00890	COG0789	Transcriptional regulator
L3X15_RS00895	COG0174	glutamine synthetase
L3X15_RS00910	COG1214	PFAM Peptidase M22, glycoprotease
L3X15_RS00920	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
L3X15_RS00925	COG2207	Transcriptional regulator
L3X15_RS00935	COG1175	transmembrane transport
L3X15_RS00940	COG0395	ABC-type sugar transport system, permease component
L3X15_RS00960	COG2855	membrane
L3X15_RS00985	COG1131	(ABC) transporter
L3X15_RS00990	COG2081	HI0933 family
L3X15_RS00995	COG2723	6-phospho-beta-galactosidase activity
L3X15_RS01005	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L3X15_RS01020	COG3959	Transketolase, thiamine diphosphate binding domain
L3X15_RS01025	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
L3X15_RS01030	COG0584	glycerophosphoryl diester phosphodiesterase
L3X15_RS01035	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
L3X15_RS01040	COG2222	sugar isomerase
L3X15_RS01065	COG1882	Formate acetyltransferase
L3X15_RS01080	COG2910	NAD(P)H-binding
L3X15_RS01100	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L3X15_RS01135	COG0363	glucosamine-6-phosphate deaminase activity
L3X15_RS01150	COG2217	Heavy metal translocating P-type atpase
L3X15_RS01155	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L3X15_RS01160	COG0681	Belongs to the peptidase S26 family
L3X15_RS01180	COG0366	Alpha amylase catalytic
L3X15_RS01185	COG1263	PTS System
L3X15_RS01185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L3X15_RS01190	COG2188	Transcriptional regulator
L3X15_RS01205	COG1193	negative regulation of DNA recombination
L3X15_RS01215	COG3118	belongs to the thioredoxin family
L3X15_RS01220	COG0318	PFAM AMP-dependent synthetase and ligase
L3X15_RS01225	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L3X15_RS01225	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L3X15_RS01245	COG1136	(ABC) transporter
L3X15_RS01250	COG1115	amino acid carrier protein
L3X15_RS01255	COG0668	transmembrane transport
L3X15_RS01265	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L3X15_RS01270	COG0167	dihydroorotate dehydrogenase activity
L3X15_RS01275	COG2843	Capsule synthesis protein
L3X15_RS01280	COG0561	phosphatase activity
L3X15_RS01295	COG1131	(ABC) transporter
L3X15_RS01300	COG1309	transcriptional regulator
L3X15_RS01305	COG1511	domain protein
L3X15_RS01330	COG1346	cytolysis
L3X15_RS01335	COG2116	formate transmembrane transporter activity
L3X15_RS01340	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L3X15_RS01345	COG0433	COG0433 Predicted ATPase
L3X15_RS01350	COG0494	nUDIX hydrolase
L3X15_RS01370	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L3X15_RS01375	COG0333	Belongs to the bacterial ribosomal protein bL32 family
L3X15_RS01380	COG0124	histidyl-tRNA synthetase
L3X15_RS01385	COG1064	alcohol dehydrogenase
L3X15_RS01390	COG1012	belongs to the aldehyde dehydrogenase family
L3X15_RS01390	COG1454	alcohol dehydrogenase
L3X15_RS01400	COG4988	ABC transporter
L3X15_RS01405	COG1132	(ABC) transporter
L3X15_RS01420	COG1129	ABC transporter
L3X15_RS01425	COG0534	Mate efflux family protein
L3X15_RS01430	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
L3X15_RS01445	COG1304	FMN binding
L3X15_RS01450	COG1132	(ABC) transporter
L3X15_RS01455	COG1132	(ABC) transporter
L3X15_RS01460	COG3830	Belongs to the UPF0237 family
L3X15_RS01465	COG2848	UPF0210 protein
L3X15_RS01470	COG0588	phosphoglycerate mutase activity
L3X15_RS01475	COG1420	regulation of RNA biosynthetic process
L3X15_RS01480	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
L3X15_RS01485	COG0443	Heat shock 70 kDa protein
L3X15_RS01490	COG0484	heat shock protein binding
L3X15_RS01495	COG0095	Lipoate-protein ligase
L3X15_RS01505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L3X15_RS01510	COG0765	amino acid transport
L3X15_RS01515	COG3655	Transcriptional regulator
L3X15_RS01525	COG2217	Heavy metal translocating P-type atpase
L3X15_RS01550	COG4475	Protein of unknown function (DUF436)
L3X15_RS01580	COG4221	oxidoreductase activity
L3X15_RS01585	COG0446	pyridine nucleotide-disulphide oxidoreductase
L3X15_RS01585	COG1902	pentaerythritol trinitrate reductase activity
L3X15_RS01590	COG1959	2 iron, 2 sulfur cluster binding
L3X15_RS01610	COG0544	peptidyl-prolyl cis-trans isomerase activity
L3X15_RS01630	COG3343	RNA polymerase activity
L3X15_RS01635	COG0504	CTP synthase activity
L3X15_RS01645	COG0191	fructose-bisphosphate aldolase activity
L3X15_RS01650	COG0227	Belongs to the bacterial ribosomal protein bL28 family
L3X15_RS01685	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L3X15_RS01690	COG0252	asparaginase activity
L3X15_RS01700	COG0589	response to stress
L3X15_RS01705	COG0436	Aminotransferase
L3X15_RS01710	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
L3X15_RS01715	COG1335	isochorismatase
L3X15_RS01720	COG0335	large ribosomal subunit rRNA binding
L3X15_RS01730	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L3X15_RS01735	COG0154	amidase activity
L3X15_RS01740	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L3X15_RS01745	COG0232	Belongs to the dGTPase family. Type 2 subfamily
L3X15_RS01750	COG1609	Transcriptional regulator
L3X15_RS01755	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
L3X15_RS01760	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
L3X15_RS01770	COG3142	Participates in the control of copper homeostasis
L3X15_RS01785	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
L3X15_RS01790	COG1534	Rna-binding protein
L3X15_RS01795	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
L3X15_RS01800	COG1713	HD superfamily hydrolase involved in NAD metabolism
L3X15_RS01820	COG0799	negative regulation of ribosome biogenesis
L3X15_RS01825	COG2226	methyltransferase
L3X15_RS01830	COG5290	Psort location Cytoplasmic, score
L3X15_RS01840	COG0789	Transcriptional regulator
L3X15_RS01845	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
L3X15_RS01865	COG0242	peptide deformylase activity
L3X15_RS01875	COG1640	4-alpha-glucanotransferase
L3X15_RS01880	COG0058	SHG alpha-glucan phosphorylase activity
L3X15_RS01895	COG2190	(PTS) system
L3X15_RS01895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L3X15_RS01895	COG1263	PTS System
L3X15_RS01910	COG0217	transcriptional regulatory protein
L3X15_RS01920	COG4720	Psort location CytoplasmicMembrane, score
L3X15_RS01930	COG1054	Belongs to the UPF0176 family
L3X15_RS01940	COG1122	ATPase activity
L3X15_RS01955	COG0357	Ribosomal RNA small subunit methyltransferase G
L3X15_RS01960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L3X15_RS01965	COG3331	DNA recombination
L3X15_RS01970	COG4474	Belongs to the UPF0398 family
L3X15_RS01975	COG3599	regulation of cell shape
L3X15_RS01985	COG0116	Belongs to the methyltransferase superfamily
L3X15_RS01995	COG1854	S-ribosylhomocysteine lyase activity
L3X15_RS02000	COG1418	mRNA catabolic process
L3X15_RS02010	COG1758	RNA polymerase activity
L3X15_RS02015	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L3X15_RS02020	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L3X15_RS02025	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L3X15_RS02025	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L3X15_RS02030	COG0631	protein serine/threonine phosphatase activity
L3X15_RS02035	COG2815	serine threonine protein kinase
L3X15_RS02035	COG0515	serine threonine protein kinase
L3X15_RS02060	COG1098	S1 RNA binding domain
L3X15_RS02070	COG1739	Uncharacterized protein family UPF0029
L3X15_RS02075	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
L3X15_RS02160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L3X15_RS02165	COG2137	regulation of response to DNA damage stimulus
L3X15_RS02170	COG3557	Belongs to the UPF0374 family
L3X15_RS02180	COG2188	Transcriptional regulator
L3X15_RS02185	COG2188	Transcriptional regulator
L3X15_RS02195	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L3X15_RS02205	COG3716	PTS system mannose fructose sorbose family IID component
L3X15_RS02215	COG2017	converts alpha-aldose to the beta-anomer
L3X15_RS02230	COG0346	lactoylglutathione lyase activity
L3X15_RS02280	COG1217	gtp-binding protein TYPA
L3X15_RS02295	COG0681	Belongs to the peptidase S26 family
L3X15_RS02330	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L3X15_RS02345	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L3X15_RS02350	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
L3X15_RS02355	COG1799	cell septum assembly
L3X15_RS02370	COG3599	regulation of cell shape
L3X15_RS02390	COG0494	nUDIX hydrolase
L3X15_RS02390	COG0406	alpha-ribazole phosphatase activity
L3X15_RS02395	COG0542	response to heat
L3X15_RS02400	COG4703	Protein of unknown function (DUF1797)
L3X15_RS02405	COG0765	amino acid transport
L3X15_RS02415	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
L3X15_RS02450	COG0789	Transcriptional regulator
L3X15_RS02465	COG0826	peptidase U32
L3X15_RS02475	COG4443	Transcriptional Coactivator p15 (PC4)
L3X15_RS02480	COG1268	BioY protein
L3X15_RS02485	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
L3X15_RS02490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L3X15_RS02495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L3X15_RS02500	COG1136	(ABC) transporter
L3X15_RS02505	COG0577	efflux transmembrane transporter activity
L3X15_RS02515	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
L3X15_RS02525	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L3X15_RS02535	COG3859	Proton-coupled thiamine transporter YuaJ
L3X15_RS02555	COG0772	Belongs to the SEDS family
L3X15_RS02560	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
L3X15_RS02565	COG1595	DNA-templated transcription, initiation
L3X15_RS02575	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L3X15_RS02580	COG0149	triose-phosphate isomerase activity
L3X15_RS02590	COG1078	dGTPase activity
L3X15_RS02605	COG2826	transposase and inactivated derivatives, IS30 family
L3X15_RS02610	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L3X15_RS02620	COG1131	(ABC) transporter
L3X15_RS02625	COG2188	Transcriptional regulator
L3X15_RS02635	COG0205	6-phosphofructokinase activity
L3X15_RS02640	COG0469	pyruvate kinase activity
L3X15_RS02650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L3X15_RS02655	COG2755	lipolytic protein G-D-S-L family
L3X15_RS02655	COG0657	acetylesterase activity
L3X15_RS02665	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L3X15_RS02670	COG0765	amino acid transport
L3X15_RS02675	COG1126	abc transporter atp-binding protein
L3X15_RS02680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L3X15_RS02705	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
L3X15_RS02710	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
L3X15_RS02715	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L3X15_RS02730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L3X15_RS02735	COG3022	response to hydroperoxide
L3X15_RS02745	COG3944	biosynthesis protein
L3X15_RS02755	COG4464	protein tyrosine phosphatase activity
L3X15_RS02770	COG0438	transferase activity, transferring glycosyl groups
L3X15_RS02785	COG1216	Glycosyl transferase, family 2
L3X15_RS02785	COG1442	glycosyl transferase family 8
L3X15_RS02790	COG1216	Glycosyl transferase, family 2
L3X15_RS02790	COG1442	glycosyl transferase family 8
L3X15_RS02820	COG2089	acid synthase
L3X15_RS02835	COG2755	lipolytic protein G-D-S-L family
L3X15_RS02835	COG1083	cytidylyl-transferase
L3X15_RS02905	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
L3X15_RS02910	COG0077	Prephenate dehydratase
L3X15_RS02920	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L3X15_RS02935	COG0270	DNA (cytosine-5-)-methyltransferase activity
L3X15_RS03085	COG1475	DNA binding
L3X15_RS03090	COG4443	Transcriptional Coactivator p15 (PC4)
L3X15_RS03125	COG1192	Involved in chromosome partitioning
L3X15_RS03175	COG3843	relaxase mobilization nuclease domain protein
L3X15_RS03225	COG1131	(ABC) transporter
L3X15_RS03265	COG0647	UMP catabolic process
L3X15_RS03275	COG0828	Belongs to the bacterial ribosomal protein bS21 family
L3X15_RS03280	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L3X15_RS03285	COG1970	mechanosensitive ion channel activity
L3X15_RS03290	COG0358	DNA primase activity
L3X15_RS03295	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L3X15_RS03300	COG2151	metal-sulfur cluster biosynthetic enzyme
L3X15_RS03335	COG2826	transposase and inactivated derivatives, IS30 family
L3X15_RS03365	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L3X15_RS03375	COG2884	Cell division ATP-binding protein ftsE
L3X15_RS03380	COG2177	Part of the ABC transporter FtsEX involved in
L3X15_RS03405	COG1132	(ABC) transporter
L3X15_RS03410	COG1132	(ABC) transporter
L3X15_RS03415	COG1011	Hydrolase
L3X15_RS03425	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
L3X15_RS03435	COG1737	Transcriptional regulator
L3X15_RS03445	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
L3X15_RS03450	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L3X15_RS03455	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L3X15_RS03465	COG2814	Major facilitator Superfamily
L3X15_RS03470	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L3X15_RS03480	COG0557	exoribonuclease II activity
L3X15_RS03485	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
L3X15_RS03490	COG1063	alcohol dehydrogenase
L3X15_RS03505	COG2217	Heavy metal translocating P-type atpase
L3X15_RS03520	COG1136	(ABC) transporter
L3X15_RS03535	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L3X15_RS03535	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L3X15_RS03545	COG1832	CoA-binding protein
L3X15_RS03555	COG0343	queuine tRNA-ribosyltransferase activity
L3X15_RS03575	COG1940	carbohydrate kinase activity
L3X15_RS03580	COG2115	Belongs to the xylose isomerase family
L3X15_RS03585	COG1070	Carbohydrate kinase
L3X15_RS03600	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L3X15_RS03605	COG3715	PTS system
L3X15_RS03610	COG3716	PTS system mannose fructose sorbose family IID component
L3X15_RS03625	COG1609	Transcriptional regulator
L3X15_RS03640	COG0438	transferase activity, transferring glycosyl groups
L3X15_RS03655	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L3X15_RS03660	COG0765	amino acid transport
L3X15_RS03665	COG0765	amino acid transport
L3X15_RS03670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L3X15_RS03675	COG1126	abc transporter atp-binding protein
L3X15_RS03680	COG0745	RESPONSE REGULATOR receiver
L3X15_RS03690	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
L3X15_RS03700	COG0488	(ABC) transporter
L3X15_RS03710	COG0768	penicillin binding
L3X15_RS03715	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L3X15_RS03720	COG1181	Belongs to the D-alanine--D-alanine ligase family
L3X15_RS03730	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L3X15_RS03740	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L3X15_RS03755	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L3X15_RS03775	COG1609	Transcriptional regulator
L3X15_RS03780	COG4209	transmembrane transport
L3X15_RS03785	COG0395	ABC-type sugar transport system, permease component
L3X15_RS03795	COG1621	beta-fructofuranosidase activity
L3X15_RS03800	COG0697	spore germination
L3X15_RS03800	COG1674	ftsk spoiiie
L3X15_RS03805	COG0346	lactoylglutathione lyase activity
L3X15_RS03830	COG0625	glutathione transferase activity
L3X15_RS03835	COG2244	polysaccharide biosynthetic process
L3X15_RS03840	COG0528	UMP kinase activity
L3X15_RS03845	COG0233	cytoplasmic translational termination
L3X15_RS03850	COG2996	Protein conserved in bacteria
L3X15_RS03865	COG4479	Belongs to the UPF0346 family
L3X15_RS03870	COG1702	phosphate starvation-inducible protein PhoH
L3X15_RS03880	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
L3X15_RS03885	COG2807	transmembrane transport
L3X15_RS03895	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
L3X15_RS03900	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L3X15_RS03910	COG1234	tRNA 3'-trailer cleavage
L3X15_RS03915	COG0300	oxidoreductase activity
L3X15_RS03925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L3X15_RS03930	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L3X15_RS03930	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
L3X15_RS03940	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L3X15_RS03955	COG2384	SAM-dependent methyltransferase
L3X15_RS03960	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L3X15_RS03970	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
L3X15_RS03985	COG1088	dTDP-glucose 4,6-dehydratase activity
L3X15_RS03990	COG1091	dTDP-4-dehydrorhamnose reductase activity
L3X15_RS04020	COG0463	Glycosyl transferase, family 2
L3X15_RS04050	COG1442	glycosyl transferase family 8
L3X15_RS04055	COG1216	Glycosyl transferase, family 2
L3X15_RS04055	COG1442	glycosyl transferase family 8
L3X15_RS04070	COG1216	Glycosyl transferase, family 2
L3X15_RS04100	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
L3X15_RS04110	COG0291	Belongs to the bacterial ribosomal protein bL35 family
L3X15_RS04125	COG1368	sulfuric ester hydrolase activity
L3X15_RS04130	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
L3X15_RS04135	COG0710	3-dehydroquinate dehydratase activity
L3X15_RS04140	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
L3X15_RS04145	COG0287	Prephenate dehydrogenase
L3X15_RS04150	COG3679	Belongs to the UPF0342 family
L3X15_RS04160	COG3684	Belongs to the aldolase LacD family
L3X15_RS04175	COG4120	Belongs to the binding-protein-dependent transport system permease family
L3X15_RS04180	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L3X15_RS04180	COG1116	anion transmembrane transporter activity
L3X15_RS04185	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
L3X15_RS04190	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L3X15_RS04195	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L3X15_RS04200	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L3X15_RS04210	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L3X15_RS04210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L3X15_RS04235	COG4122	O-methyltransferase activity
L3X15_RS04240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L3X15_RS04250	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L3X15_RS04270	COG1476	TRANSCRIPTIONal
L3X15_RS04305	COG1028	Short-chain dehydrogenase reductase Sdr
L3X15_RS04330	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
L3X15_RS04335	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L3X15_RS04345	COG3716	PTS system mannose fructose sorbose family IID component
L3X15_RS04375	COG1609	Transcriptional regulator
L3X15_RS04380	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L3X15_RS04390	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L3X15_RS04395	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L3X15_RS04400	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L3X15_RS04405	COG0372	Belongs to the citrate synthase family
L3X15_RS04410	COG0538	isocitrate dehydrogenase activity
L3X15_RS04415	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L3X15_RS04430	COG2826	transposase and inactivated derivatives, IS30 family
L3X15_RS04455	COG1196	nuclear chromosome segregation
L3X15_RS04460	COG0561	phosphatase activity
L3X15_RS04465	COG0561	phosphatase activity
L3X15_RS04470	COG0552	protein localization to endoplasmic reticulum
L3X15_RS04485	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L3X15_RS04490	COG3689	TIGRFAM TIGR03943 family protein
L3X15_RS04495	COG0701	Predicted permease
L3X15_RS04510	COG1597	lipid kinase activity
L3X15_RS04520	COG0356	it plays a direct role in the translocation of protons across the membrane
L3X15_RS04525	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
L3X15_RS04530	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L3X15_RS04535	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
L3X15_RS04540	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
L3X15_RS04545	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
L3X15_RS04550	COG0355	proton-transporting ATP synthase activity, rotational mechanism
L3X15_RS04560	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L3X15_RS04575	COG2211	Major facilitator Superfamily
L3X15_RS04585	COG3250	beta-galactosidase activity
L3X15_RS04595	COG0800	Aldolase
L3X15_RS04605	COG1312	Catalyzes the dehydration of D-mannonate
L3X15_RS04610	COG1028	Short-chain dehydrogenase reductase Sdr
L3X15_RS04640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L3X15_RS04640	COG0072	phenylalanine-tRNA ligase activity
L3X15_RS04665	COG1051	belongs to the nudix hydrolase family
L3X15_RS04670	COG0302	gtp cyclohydrolase
L3X15_RS04690	COG2610	gluconate transmembrane transporter activity
L3X15_RS04695	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
L3X15_RS04710	COG1846	Transcriptional regulator
L3X15_RS04715	COG3759	membrane
L3X15_RS04725	COG1695	Transcriptional regulator
L3X15_RS04740	COG2195	Cleaves the N-terminal amino acid of tripeptides
L3X15_RS04745	COG0561	phosphatase activity
L3X15_RS04785	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L3X15_RS04790	COG0196	riboflavin kinase activity
L3X15_RS04795	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L3X15_RS04800	COG1393	Belongs to the ArsC family
L3X15_RS04805	COG4476	Belongs to the UPF0223 family
L3X15_RS04810	COG0483	inositol monophosphate 1-phosphatase activity
L3X15_RS04815	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
L3X15_RS04815	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L3X15_RS04825	COG0573	inorganic phosphate transmembrane transporter activity
L3X15_RS04830	COG0581	inorganic phosphate transmembrane transporter activity
L3X15_RS04835	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L3X15_RS04840	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L3X15_RS04845	COG0704	Plays a role in the regulation of phosphate uptake
L3X15_RS04855	COG0745	RESPONSE REGULATOR receiver
L3X15_RS04860	COG5002	protein histidine kinase activity
L3X15_RS04875	COG0268	Binds directly to 16S ribosomal RNA
L3X15_RS04880	COG1072	(Pantothenic acid kinase))
L3X15_RS04885	COG2813	Specifically methylates the guanine in position
L3X15_RS04890	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
L3X15_RS04905	COG1744	ABC transporter substrate-binding protein PnrA-like
L3X15_RS04910	COG3845	ABC transporter
L3X15_RS04915	COG4603	Belongs to the binding-protein-dependent transport system permease family
L3X15_RS04920	COG1079	Belongs to the binding-protein-dependent transport system permease family
L3X15_RS04925	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L3X15_RS04930	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L3X15_RS04935	COG0039	L-malate dehydrogenase activity
L3X15_RS04940	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L3X15_RS04945	COG3764	Sortase (surface protein transpeptidase)
L3X15_RS04955	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
L3X15_RS04960	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
L3X15_RS04975	COG1104	cysteine desulfurase activity
L3X15_RS04985	COG4116	CYTH
L3X15_RS04990	COG2357	RelA SpoT domain protein
L3X15_RS04995	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L3X15_RS05000	COG0564	pseudouridine synthase activity
L3X15_RS05005	COG0280	phosphate acetyltransferase
L3X15_RS05010	COG1132	(ABC) transporter
L3X15_RS05015	COG1132	(ABC) transporter
L3X15_RS05025	COG1194	a g-specific adenine glycosylase
L3X15_RS05030	COG1396	sequence-specific DNA binding
L3X15_RS05060	COG1349	DNA-binding transcription factor activity
L3X15_RS05065	COG0698	ribose 5-phosphate isomerase
L3X15_RS05070	COG0698	ribose 5-phosphate isomerase
L3X15_RS05080	COG3684	Belongs to the aldolase LacD family
L3X15_RS05085	COG3711	transcriptional antiterminator
L3X15_RS05095	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L3X15_RS05095	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L3X15_RS05120	COG2873	o-acetylhomoserine
L3X15_RS05125	COG0488	(ABC) transporter
L3X15_RS05135	COG1126	abc transporter atp-binding protein
L3X15_RS05160	COG3583	domain protein
L3X15_RS05175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L3X15_RS05180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L3X15_RS05190	COG0297	glycogen (starch) synthase activity
L3X15_RS05215	COG0167	dihydroorotate dehydrogenase activity
L3X15_RS05220	COG0284	orotidine-5'-phosphate decarboxylase activity
L3X15_RS05225	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L3X15_RS05235	COG0463	Glycosyl transferase, family 2
L3X15_RS05240	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
L3X15_RS05250	COG0737	Belongs to the 5'-nucleotidase family
L3X15_RS05265	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
L3X15_RS05270	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L3X15_RS05280	COG1272	protein, Hemolysin III
L3X15_RS05290	COG0446	pyridine nucleotide-disulphide oxidoreductase
L3X15_RS05300	COG1937	Protein conserved in bacteria
L3X15_RS05305	COG0110	maltose O-acetyltransferase activity
L3X15_RS05310	COG0758	DNA mediated transformation
L3X15_RS05315	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L3X15_RS05320	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
L3X15_RS05325	COG0222	ribosome binding
L3X15_RS05330	COG0647	UMP catabolic process
L3X15_RS05335	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
L3X15_RS05340	COG2207	Transcriptional regulator
L3X15_RS05340	COG3708	Transcriptional regulator
L3X15_RS05350	COG2382	esterase
L3X15_RS05390	COG1136	(ABC) transporter
L3X15_RS05410	COG0745	RESPONSE REGULATOR receiver
L3X15_RS05425	COG4974	Belongs to the 'phage' integrase family
L3X15_RS05430	COG1660	Displays ATPase and GTPase activities
L3X15_RS05445	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L3X15_RS05450	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
L3X15_RS05455	COG2188	Transcriptional regulator
L3X15_RS05465	COG4268	DNA restriction-modification system
L3X15_RS05470	COG1401	restriction endodeoxyribonuclease activity
L3X15_RS05495	COG4221	oxidoreductase activity
L3X15_RS05500	COG0741	lytic transglycosylase activity
L3X15_RS05510	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L3X15_RS05520	COG0009	L-threonylcarbamoyladenylate synthase
L3X15_RS05525	COG2890	protein-(glutamine-N5) methyltransferase activity
L3X15_RS05530	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
L3X15_RS05550	COG0481	GTPase activity
L3X15_RS05570	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
L3X15_RS05575	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L3X15_RS05580	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
L3X15_RS05595	COG1940	carbohydrate kinase activity
L3X15_RS05605	COG0488	(ABC) transporter
L3X15_RS05610	COG0617	tRNA 3'-terminal CCA addition
L3X15_RS05615	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
L3X15_RS05620	COG1307	EDD domain protein, DegV family
L3X15_RS05630	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L3X15_RS05630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L3X15_RS05630	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L3X15_RS05635	COG1105	Belongs to the carbohydrate kinase PfkB family
L3X15_RS05640	COG1349	DNA-binding transcription factor activity
L3X15_RS05645	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L3X15_RS05650	COG0336	Belongs to the RNA methyltransferase TrmD family
L3X15_RS05655	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L3X15_RS05660	COG0534	Mate efflux family protein
L3X15_RS05670	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L3X15_RS05675	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L3X15_RS05690	COG0038	chloride channel
L3X15_RS05700	COG1177	transmembrane transport
L3X15_RS05705	COG1176	ABC-type spermidine putrescine transport system, permease component I
L3X15_RS05710	COG3842	ATPase activity
L3X15_RS05715	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L3X15_RS05720	COG0083	homoserine kinase activity
L3X15_RS05725	COG0460	homoserine dehydrogenase
L3X15_RS05730	COG0726	polysaccharide deacetylase
L3X15_RS05735	COG1132	(ABC) transporter
L3X15_RS05750	COG0228	four-way junction DNA binding
L3X15_RS05760	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
L3X15_RS05765	COG2136	Putative SAM-dependent methyltransferase
L3X15_RS05765	COG2521	methyltransferase
L3X15_RS05775	COG0505	Belongs to the CarA family
L3X15_RS05780	COG0540	Belongs to the ATCase OTCase family
L3X15_RS05785	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
L3X15_RS05795	COG2824	Alkylphosphonate utilization operon protein PhnA
L3X15_RS05800	COG0564	pseudouridine synthase activity
L3X15_RS05820	COG0211	Belongs to the bacterial ribosomal protein bL27 family
L3X15_RS05825	COG0261	This protein binds to 23S rRNA in the presence of protein L20
L3X15_RS05830	COG1114	Component of the transport system for branched-chain amino acids
L3X15_RS05835	COG0301	tRNA thio-modification
L3X15_RS05840	COG1104	cysteine desulfurase activity
L3X15_RS05865	COG0539	negative regulation of cytoplasmic translation
L3X15_RS05885	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L3X15_RS05895	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L3X15_RS05920	COG0187	DNA topoisomerase II activity
L3X15_RS05930	COG1074	ATP-dependent DNA helicase activity
L3X15_RS05935	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
L3X15_RS05975	COG1131	(ABC) transporter
L3X15_RS06005	COG1011	Hydrolase
L3X15_RS06010	COG1122	ATPase activity
L3X15_RS06015	COG1122	ATPase activity
L3X15_RS06030	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
L3X15_RS06045	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
L3X15_RS06060	COG0210	DNA helicase
L3X15_RS06075	COG1164	Oligoendopeptidase f
L3X15_RS06085	COG0346	lactoylglutathione lyase activity
L3X15_RS06090	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L3X15_RS06095	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
L3X15_RS06100	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L3X15_RS06110	COG0446	pyridine nucleotide-disulphide oxidoreductase
L3X15_RS06115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L3X15_RS06120	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L3X15_RS06140	COG1882	Formate acetyltransferase
L3X15_RS06145	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L3X15_RS06150	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L3X15_RS06155	COG1447	Phosphotransferase system cellobiose-specific component IIA
L3X15_RS06165	COG1349	DNA-binding transcription factor activity
L3X15_RS06170	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
L3X15_RS06205	COG0732	type I restriction modification DNA specificity domain
L3X15_RS06215	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
L3X15_RS06220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L3X15_RS06230	COG2759	Belongs to the formate--tetrahydrofolate ligase family
L3X15_RS06240	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L3X15_RS06245	COG4684	Psort location CytoplasmicMembrane, score
L3X15_RS06250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L3X15_RS06290	COG0531	amino acid
L3X15_RS06300	COG0708	Exodeoxyribonuclease III
L3X15_RS06310	COG1393	Belongs to the ArsC family
L3X15_RS06315	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L3X15_RS06320	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L3X15_RS06330	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
L3X15_RS06340	COG4467	Involved in initiation control of chromosome replication
L3X15_RS06345	COG0470	DNA polymerase III
L3X15_RS06350	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
L3X15_RS06355	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L3X15_RS06370	COG0517	IMP dehydrogenase activity
L3X15_RS06380	COG0658	competence protein
L3X15_RS06380	COG2333	competence protein COMEC
L3X15_RS06385	COG1555	photosystem II stabilization
L3X15_RS06385	COG1596	polysaccharide export
L3X15_RS06390	COG0204	Acyl-transferase
L3X15_RS06395	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L3X15_RS06400	COG1120	ATPase activity
L3X15_RS06405	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L3X15_RS06410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L3X15_RS06415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L3X15_RS06420	COG0386	Belongs to the glutathione peroxidase family
L3X15_RS06425	COG1187	pseudouridine synthase activity
L3X15_RS06430	COG0435	Glutathione S-transferase
L3X15_RS06440	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
L3X15_RS06445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L3X15_RS06450	COG1696	Membrane protein involved in D-alanine export
L3X15_RS06480	COG0363	glucosamine-6-phosphate deaminase activity
L3X15_RS06490	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
L3X15_RS06495	COG1438	arginine binding
L3X15_RS06510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L3X15_RS06515	COG1288	antiporter activity
L3X15_RS06520	COG0549	Belongs to the carbamate kinase family
L3X15_RS06525	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
L3X15_RS06530	COG0454	-acetyltransferase
L3X15_RS06545	COG1481	regulation of sporulation
L3X15_RS06550	COG0391	Required for morphogenesis under gluconeogenic growth conditions
L3X15_RS06555	COG1660	Displays ATPase and GTPase activities
L3X15_RS06560	COG0251	oxidation-reduction process
L3X15_RS06565	COG0534	Mate efflux family protein
L3X15_RS06585	COG0436	Aminotransferase
L3X15_RS06605	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L3X15_RS06665	COG1131	(ABC) transporter
L3X15_RS06685	COG3843	relaxase mobilization nuclease domain protein
L3X15_RS06700	COG0613	PHP domain protein
L3X15_RS06705	COG0542	response to heat
L3X15_RS06710	COG1396	sequence-specific DNA binding
L3X15_RS06765	COG4443	Transcriptional Coactivator p15 (PC4)
L3X15_RS06770	COG1475	DNA binding
L3X15_RS06900	COG0270	DNA (cytosine-5-)-methyltransferase activity
L3X15_RS06925	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L3X15_RS06935	COG0058	SHG alpha-glucan phosphorylase activity
L3X15_RS06940	COG0813	purine-nucleoside phosphorylase activity
L3X15_RS06945	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
L3X15_RS06955	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
L3X15_RS06960	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
L3X15_RS06965	COG0732	type I restriction modification DNA specificity domain
L3X15_RS06985	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
L3X15_RS07000	COG2268	Band 7 protein
L3X15_RS07005	COG1704	LemA family
L3X15_RS07015	COG1573	uracil-dna glycosylase
L3X15_RS07050	COG2226	methyltransferase
L3X15_RS07055	COG0488	(ABC) transporter
L3X15_RS07060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L3X15_RS07075	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L3X15_RS07080	COG3442	glutamine amidotransferase
L3X15_RS07085	COG2226	methyltransferase
L3X15_RS07095	COG0488	(ABC) transporter
L3X15_RS07130	COG3842	ATPase activity
L3X15_RS07145	COG1293	RNA-binding protein homologous to eukaryotic snRNP
L3X15_RS07150	COG3527	Alpha-acetolactate decarboxylase
L3X15_RS07160	COG0628	permease
L3X15_RS07165	COG2706	6-phosphogluconolactonase activity
L3X15_RS07175	COG1011	Hydrolase
L3X15_RS07210	COG0560	Phosphoserine phosphatase
L3X15_RS07215	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
L3X15_RS07220	COG0187	DNA topoisomerase II activity
L3X15_RS07225	COG0693	protein deglycase activity
L3X15_RS07230	COG0772	Belongs to the SEDS family
L3X15_RS07235	COG0582	viral genome integration into host DNA
L3X15_RS07320	COG0582	viral genome integration into host DNA
L3X15_RS07335	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
L3X15_RS07340	COG0716	FMN binding
L3X15_RS07350	COG0287	Prephenate dehydrogenase
L3X15_RS07350	COG1605	Chorismate mutase
L3X15_RS07355	COG0038	chloride channel
L3X15_RS07365	COG0737	Belongs to the 5'-nucleotidase family
L3X15_RS07370	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L3X15_RS07375	COG1466	dna polymerase III delta subunit
L3X15_RS07410	COG0683	leucine binding
L3X15_RS07425	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
L3X15_RS07430	COG0366	Alpha amylase catalytic
L3X15_RS07440	COG0395	ABC-type sugar transport system, permease component
L3X15_RS07445	COG1175	transmembrane transport
L3X15_RS07450	COG1653	transport
L3X15_RS07460	COG2207	Transcriptional regulator
L3X15_RS07465	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
L3X15_RS07470	COG0626	cystathionine gamma-synthase activity
L3X15_RS07490	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
L3X15_RS07495	COG2827	Endonuclease containing a URI domain
L3X15_RS07520	COG0640	Transcriptional regulator
L3X15_RS07525	COG0513	Belongs to the DEAD box helicase family
L3X15_RS07530	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L3X15_RS07575	COG0494	nUDIX hydrolase
L3X15_RS07580	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L3X15_RS07595	COG1028	Short-chain dehydrogenase reductase Sdr
L3X15_RS07625	COG0577	efflux transmembrane transporter activity
L3X15_RS07630	COG1136	(ABC) transporter
L3X15_RS07635	COG2205	protein histidine kinase activity
L3X15_RS07650	COG0436	Aminotransferase
L3X15_RS07660	COG1174	glycine betaine transport
L3X15_RS07665	COG1125	glycine betaine transport
L3X15_RS07665	COG0517	IMP dehydrogenase activity
L3X15_RS07685	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
L3X15_RS07690	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
L3X15_RS07695	COG1482	cell wall glycoprotein biosynthetic process
L3X15_RS07710	COG3091	SprT-like family
L3X15_RS07715	COG2183	response to ionizing radiation
L3X15_RS07720	COG0656	L-ascorbic acid biosynthetic process
L3X15_RS07725	COG4708	membrane
L3X15_RS07730	COG2246	polysaccharide biosynthetic process
L3X15_RS07740	COG0024	Methionine aminopeptidase
L3X15_RS07750	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L3X15_RS07755	COG2249	NAD(P)H dehydrogenase (quinone) activity
L3X15_RS07760	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
L3X15_RS07765	COG2131	deaminase
L3X15_RS07775	COG1363	Peptidase, m42
L3X15_RS07790	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L3X15_RS07795	COG1956	GAF domain-containing protein
L3X15_RS07805	COG1695	Transcriptional regulator
L3X15_RS07820	COG0513	Belongs to the DEAD box helicase family
L3X15_RS07825	COG0726	polysaccharide deacetylase
L3X15_RS07845	COG0183	Belongs to the thiolase family
L3X15_RS07850	COG3425	synthase
L3X15_RS07875	COG0776	regulation of translation
L3X15_RS07885	COG2755	lipolytic protein G-D-S-L family
L3X15_RS07890	COG1307	EDD domain protein, DegV family
L3X15_RS07895	COG0497	DNA recombination
L3X15_RS07900	COG1438	arginine binding
L3X15_RS07905	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
L3X15_RS07915	COG1722	exodeoxyribonuclease VII activity
L3X15_RS07920	COG1570	exodeoxyribonuclease VII activity
L3X15_RS07925	COG2321	neutral zinc metallopeptidase
L3X15_RS07930	COG1755	Isoprenylcysteine carboxyl methyltransferase
L3X15_RS07935	COG5002	protein histidine kinase activity
L3X15_RS07940	COG0745	RESPONSE REGULATOR receiver
L3X15_RS07965	COG1227	inorganic diphosphatase activity
L3X15_RS07975	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
L3X15_RS07980	COG1253	flavin adenine dinucleotide binding
L3X15_RS07985	COG1119	ATPase activity
L3X15_RS07990	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
L3X15_RS08000	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
L3X15_RS08005	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L3X15_RS08020	COG4470	Protein conserved in bacteria
L3X15_RS08025	COG3480	Lon protease (S16) C-terminal proteolytic domain
L3X15_RS08030	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
L3X15_RS08035	COG0742	ribosomal rna small subunit methyltransferase
L3X15_RS08045	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L3X15_RS08050	COG4483	Protein conserved in bacteria
L3X15_RS08055	COG2197	response regulator
L3X15_RS08060	COG4585	Histidine kinase
L3X15_RS08060	COG2203	Gaf domain
L3X15_RS08065	COG0842	Transport permease protein
L3X15_RS08070	COG1131	(ABC) transporter
L3X15_RS08085	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L3X15_RS08100	COG0671	phosphoesterase, PA-phosphatase related
L3X15_RS08105	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
L3X15_RS08115	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
L3X15_RS08120	COG1187	pseudouridine synthase activity
L3X15_RS08125	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L3X15_RS08130	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L3X15_RS08135	COG0582	viral genome integration into host DNA
L3X15_RS08155	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L3X15_RS08160	COG3763	UPF0154 protein
L3X15_RS08170	COG3579	cysteine-type endopeptidase activity
L3X15_RS08185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L3X15_RS08190	COG1254	Belongs to the acylphosphatase family
L3X15_RS08200	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L3X15_RS08205	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L3X15_RS08215	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L3X15_RS08225	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L3X15_RS08235	COG1160	GTP binding
L3X15_RS08245	COG1484	DNA-dependent DNA replication
L3X15_RS08255	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
L3X15_RS08260	COG0628	permease
L3X15_RS08265	COG0745	RESPONSE REGULATOR receiver
L3X15_RS08270	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
L3X15_RS08280	COG0492	ferredoxin-NADP+ reductase activity
L3X15_RS08290	COG0513	Belongs to the DEAD box helicase family
L3X15_RS08300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L3X15_RS08305	COG0768	penicillin binding
L3X15_RS08315	COG0275	rRNA processing
L3X15_RS08365	COG4939	FMN-binding domain protein
L3X15_RS08370	COG0142	geranyltranstransferase activity
L3X15_RS08375	COG1252	NADH dehydrogenase
L3X15_RS08385	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L3X15_RS08390	COG0569	domain protein
L3X15_RS08395	COG0534	Mate efflux family protein
L3X15_RS08405	COG4224	UPF0291 protein
L3X15_RS08410	COG0751	glycine-tRNA ligase activity
L3X15_RS08435	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L3X15_RS08440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L3X15_RS08445	COG1464	Belongs to the NlpA lipoprotein family
L3X15_RS08450	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
L3X15_RS08455	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
L3X15_RS08460	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L3X15_RS08465	COG2252	PERMEase
L3X15_RS08470	COG0561	phosphatase activity
L3X15_RS08480	COG3715	PTS system
L3X15_RS08485	COG3716	PTS system mannose fructose sorbose family IID component
L3X15_RS08510	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
L3X15_RS08555	COG0439	Biotin carboxylase
L3X15_RS08575	COG1028	Short-chain dehydrogenase reductase Sdr
L3X15_RS08580	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L3X15_RS08585	COG2070	2-Nitropropane dioxygenase
L3X15_RS08595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L3X15_RS08605	COG1024	Enoyl-CoA hydratase
L3X15_RS08610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L3X15_RS08615	COG0527	aspartate kinase activity
L3X15_RS08620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L3X15_RS08625	COG0736	holo-[acyl-carrier-protein] synthase activity
L3X15_RS08630	COG0653	protein targeting
L3X15_RS08640	COG1940	carbohydrate kinase activity
L3X15_RS08645	COG1263	PTS System
L3X15_RS08645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L3X15_RS08645	COG2190	(PTS) system
L3X15_RS08650	COG1621	beta-fructofuranosidase activity
L3X15_RS08655	COG1609	Transcriptional regulator
L3X15_RS08660	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L3X15_RS08675	COG0006	proline dipeptidase activity
L3X15_RS08680	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L3X15_RS08695	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
L3X15_RS08700	COG0629	single-stranded DNA binding
L3X15_RS08710	COG2826	transposase and inactivated derivatives, IS30 family
L3X15_RS08715	COG0095	Lipoate-protein ligase
L3X15_RS08730	COG0508	dehydrogenase complex catalyzes the overall conversion of
L3X15_RS08735	COG0508	dehydrogenase complex catalyzes the overall conversion of
L3X15_RS08735	COG0022	dehydrogenase e1 component
L3X15_RS08740	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L3X15_RS08745	COG2860	membrane
L3X15_RS08760	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
L3X15_RS08765	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
L3X15_RS08775	COG2740	Nucleic-acid-binding protein implicated in transcription termination
L3X15_RS08780	COG0195	Participates in both transcription termination and antitermination
L3X15_RS08790	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L3X15_RS08800	COG4473	ABC transporter
L3X15_RS08805	COG1131	(ABC) transporter
L3X15_RS08810	COG0537	adenosine 5'-monophosphoramidase activity
L3X15_RS08820	COG1316	TRANSCRIPTIONal
L3X15_RS08830	COG0802	atpase or kinase
L3X15_RS08835	COG1461	Dihydroxyacetone kinase
L3X15_RS08850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L3X15_RS08855	COG0601	transmembrane transport
L3X15_RS08860	COG4608	Belongs to the ABC transporter superfamily
L3X15_RS08875	COG1686	Belongs to the peptidase S11 family
L3X15_RS08890	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L3X15_RS08895	COG0719	Fe-S assembly protein
L3X15_RS08905	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L3X15_RS08910	COG4862	establishment of competence for transformation
L3X15_RS08915	COG1968	undecaprenyl-diphosphatase activity
L3X15_RS08920	COG0765	amino acid transport
L3X15_RS08940	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L3X15_RS08945	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L3X15_RS08950	COG0440	acetolactate synthase activity
L3X15_RS08955	COG0028	Belongs to the TPP enzyme family
L3X15_RS08975	COG0129	dihydroxy-acid dehydratase activity
L3X15_RS08985	COG2151	metal-sulfur cluster biosynthetic enzyme
L3X15_RS09020	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L3X15_RS09035	COG0488	(ABC) transporter
L3X15_RS09080	COG1192	Involved in chromosome partitioning
L3X15_RS09115	COG0789	Transcriptional regulator
L3X15_RS09115	COG4978	Transcriptional regulator
L3X15_RS09165	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
L3X15_RS09180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L3X15_RS09205	COG3842	ATPase activity
L3X15_RS09215	COG2207	Transcriptional regulator
L3X15_RS09215	COG4753	response regulator
L3X15_RS09220	COG2972	Histidine kinase
L3X15_RS09235	COG1653	transport
L3X15_RS09240	COG0395	ABC-type sugar transport system, permease component
L3X15_RS09245	COG1175	transmembrane transport
L3X15_RS09260	COG0383	alpha-mannosidase activity
L3X15_RS09280	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
L3X15_RS09295	COG1045	serine acetyltransferase
L3X15_RS09300	COG1185	polyribonucleotide nucleotidyltransferase activity
L3X15_RS09320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L3X15_RS09320	COG1263	PTS System
L3X15_RS09325	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
L3X15_RS09330	COG1737	Transcriptional regulator
L3X15_RS09335	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
L3X15_RS09355	COG1187	pseudouridine synthase activity
L3X15_RS09375	COG0242	peptide deformylase activity
L3X15_RS09385	COG0066	3-isopropylmalate dehydratase activity
L3X15_RS09410	COG2309	aminopeptidase activity
L3X15_RS09425	COG2176	DNA-directed DNA polymerase activity
L3X15_RS09430	COG2376	Dihydroxyacetone kinase
L3X15_RS09440	COG2376	Dihydroxyacetone kinase
L3X15_RS09445	COG1461	Dihydroxyacetone kinase
L3X15_RS09450	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
L3X15_RS09455	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L3X15_RS09460	COG0442	prolyl-tRNA aminoacylation
L3X15_RS09470	COG4589	Belongs to the CDS family
L3X15_RS09475	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L3X15_RS09480	COG1862	Preprotein translocase
L3X15_RS09490	COG2918	glutathione biosynthetic process
L3X15_RS09490	COG1181	Belongs to the D-alanine--D-alanine ligase family
L3X15_RS09500	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
L3X15_RS09505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L3X15_RS09520	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
L3X15_RS09530	COG4463	regulation of RNA biosynthetic process
L3X15_RS09545	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
L3X15_RS09580	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L3X15_RS09585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L3X15_RS09590	COG0492	ferredoxin-NADP+ reductase activity
L3X15_RS09595	COG0564	pseudouridine synthase activity
L3X15_RS09600	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L3X15_RS09620	COG1564	THIamine pyrophosphokinase
L3X15_RS09630	COG1162	GTPase activity
L3X15_RS09675	COG4115	mRNA cleavage
L3X15_RS09710	COG0084	hydrolase, TatD family'
L3X15_RS09720	COG1847	R3H domain protein
L3X15_RS09730	COG0594	ribonuclease P activity
L3X15_RS09735	COG0165	Argininosuccinate lyase
L3X15_RS09740	COG0137	argininosuccinate synthase activity
L3X15_RS09750	COG1827	regulation of RNA biosynthetic process
L3X15_RS09765	COG2040	homocysteine
L3X15_RS09770	COG0833	amino acid
L3X15_RS09815	COG0756	dUTP diphosphatase activity
L3X15_RS09820	COG1132	(ABC) transporter
L3X15_RS09825	COG1132	(ABC) transporter
L3X15_RS09835	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
L3X15_RS09840	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L3X15_RS09845	COG0705	Rhomboid family
L3X15_RS09850	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L3X15_RS09855	COG1473	amidohydrolase
L3X15_RS09860	COG2171	N-acyltransferase activity
L3X15_RS09875	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L3X15_RS09900	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L3X15_RS09925	COG3623	hexulose-6-phosphate isomerase
L3X15_RS09950	COG1523	belongs to the glycosyl hydrolase 13 family
L3X15_RS09955	COG1609	Transcriptional regulator
L3X15_RS09960	COG1126	abc transporter atp-binding protein
L3X15_RS09965	COG0765	amino acid transport
L3X15_RS09970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L3X15_RS09975	COG3942	CHAP domain
L3X15_RS09980	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L3X15_RS09990	COG1447	Phosphotransferase system cellobiose-specific component IIA
L3X15_RS10000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L3X15_RS10000	COG3711	transcriptional antiterminator
L3X15_RS10010	COG2723	6-phospho-beta-galactosidase activity
L3X15_RS10015	COG1486	melibiose metabolic process
L3X15_RS10025	COG3590	peptidase
L3X15_RS10030	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L3X15_RS10035	COG1321	iron dependent repressor
L3X15_RS10035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L3X15_RS10040	COG1121	(ABC) transporter
L3X15_RS10045	COG0803	Belongs to the bacterial solute-binding protein 9 family
L3X15_RS10080	COG1490	D-aminoacyl-tRNA deacylase activity
L3X15_RS10090	COG0737	Belongs to the 5'-nucleotidase family
L3X15_RS10135	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L3X15_RS10160	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L3X15_RS10185	COG0737	Belongs to the 5'-nucleotidase family
L3X15_RS10190	COG1328	CTP reductase activity
L3X15_RS10220	COG1438	arginine binding
L3X15_RS10225	COG0018	arginyl-trna synthetase
L3X15_RS10245	COG1640	4-alpha-glucanotransferase
L3X15_RS10250	COG2182	Extracellular solute-binding protein
L3X15_RS10255	COG1175	transmembrane transport
L3X15_RS10260	COG3833	ABC-type maltose transport systems, permease component
L3X15_RS10265	COG5521	maltodextrose utilization protein MalA
L3X15_RS10270	COG1609	Transcriptional regulator
L3X15_RS10275	COG1523	belongs to the glycosyl hydrolase 13 family
L3X15_RS10280	COG1780	Probably involved in ribonucleotide reductase function
L3X15_RS10285	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L3X15_RS10290	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
L3X15_RS10295	COG2153	protein acetylation
L3X15_RS10300	COG4989	oxidoreductase activity
L3X15_RS10305	COG1216	Glycosyl transferase, family 2
L3X15_RS10310	COG1472	Belongs to the glycosyl hydrolase 3 family
L3X15_RS10350	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
L3X15_RS10360	COG0305	Participates in initiation and elongation during chromosome replication
L3X15_RS10365	COG0359	binds to the 23S rRNA
L3X15_RS10375	COG0445	tRNA wobble uridine modification
L3X15_RS10390	COG1051	belongs to the nudix hydrolase family
L3X15_RS10395	COG1733	regulation of RNA biosynthetic process
L3X15_RS10405	COG0482	sulfurtransferase activity
L3X15_RS10410	COG1760	l-serine dehydratase
L3X15_RS10415	COG1760	l-serine dehydratase
L3X15_RS10425	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
L3X15_RS10430	COG1122	ATPase activity
L3X15_RS10435	COG1122	ATPase activity
L3X15_RS10440	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L3X15_RS10445	COG1426	Protein conserved in bacteria
L3X15_RS10450	COG0612	Peptidase, M16
L3X15_RS10455	COG0612	Peptidase, M16
L3X15_RS10465	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L3X15_RS10470	COG0516	GMP reductase activity
L3X15_RS10470	COG0517	IMP dehydrogenase activity
L3X15_RS10480	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L3X15_RS10485	COG0488	(ABC) transporter
L3X15_RS10515	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
L3X15_RS10520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L3X15_RS10525	COG1475	DNA binding
L3X15_RS10530	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids