locus-tag	class	description
YYK_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
YYK_RS00010	COG0592	DNA-directed DNA polymerase activity
YYK_RS00030	COG0012	GTP binding
YYK_RS00035	COG0193	aminoacyl-tRNA hydrolase activity
YYK_RS00040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
YYK_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
YYK_RS00065	COG0037	tRNA processing
YYK_RS00075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
YYK_RS00185	COG1792	Involved in formation and maintenance of cell shape
YYK_RS00200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
YYK_RS00205	COG0436	Aminotransferase
YYK_RS00210	COG1381	Involved in DNA repair and RecF pathway recombination
YYK_RS00215	COG0416	fatty acid biosynthetic process
YYK_RS00220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YYK_RS00230	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
YYK_RS00245	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
YYK_RS00250	COG0138	bifunctional purine biosynthesis protein purh
YYK_RS00255	COG0151	Belongs to the GarS family
YYK_RS00260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
YYK_RS00280	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
YYK_RS00300	COG1131	(ABC) transporter
YYK_RS00310	COG1132	(ABC) transporter
YYK_RS00315	COG2255	four-way junction helicase activity
YYK_RS00325	COG0546	phosphoglycolate phosphatase activity
YYK_RS00350	COG0285	dihydrofolate synthase activity
YYK_RS00365	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
YYK_RS00370	COG0632	four-way junction helicase activity
YYK_RS00380	COG0519	Catalyzes the synthesis of GMP from XMP
YYK_RS00395	COG1393	Belongs to the ArsC family
YYK_RS00400	COG4472	Bacterial protein of unknown function (DUF965)
YYK_RS00405	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
YYK_RS00410	COG3906	Belongs to the UPF0473 family
YYK_RS00430	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
YYK_RS00435	COG0088	Forms part of the polypeptide exit tunnel
YYK_RS00440	COG0089	rRNA binding
YYK_RS00445	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
YYK_RS00450	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
YYK_RS00455	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
YYK_RS00460	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
YYK_RS00465	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
YYK_RS00470	COG0255	Belongs to the universal ribosomal protein uL29 family
YYK_RS00475	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
YYK_RS00480	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
YYK_RS00485	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
YYK_RS00490	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
YYK_RS00495	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
YYK_RS00505	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
YYK_RS00515	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
YYK_RS00520	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
YYK_RS00525	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
YYK_RS00530	COG1841	ribosomal large subunit assembly
YYK_RS00540	COG0201	protein transport
YYK_RS00545	COG0563	adenylate kinase activity
YYK_RS00550	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
YYK_RS00555	COG0257	Belongs to the bacterial ribosomal protein bL36 family
YYK_RS00560	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
YYK_RS00570	COG0202	RNA polymerase activity
YYK_RS00675	COG1121	(ABC) transporter
YYK_RS00680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
YYK_RS00685	COG0803	Belongs to the bacterial solute-binding protein 9 family
YYK_RS00685	COG3443	Belongs to the bacterial solute-binding protein 9 family
YYK_RS00715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
YYK_RS00720	COG0085	RNA polymerase activity
YYK_RS00725	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
YYK_RS00740	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
YYK_RS00745	COG1459	type II secretion system
YYK_RS00750	COG4537	Required for transformation and DNA binding
YYK_RS00780	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
YYK_RS00790	COG0285	dihydrofolate synthase activity
YYK_RS00795	COG1363	Peptidase, m42
YYK_RS00805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
YYK_RS00815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
YYK_RS00840	COG0459	protein refolding
YYK_RS00850	COG0049	tRNA binding
YYK_RS00855	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
YYK_RS00860	COG3590	peptidase
YYK_RS00870	COG0126	phosphoglycerate kinase activity
YYK_RS00880	COG0789	Transcriptional regulator
YYK_RS00885	COG0174	glutamine synthetase
YYK_RS00900	COG1214	PFAM Peptidase M22, glycoprotease
YYK_RS00910	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
YYK_RS00915	COG2207	Transcriptional regulator
YYK_RS00925	COG1175	transmembrane transport
YYK_RS00930	COG0395	ABC-type sugar transport system, permease component
YYK_RS00950	COG2855	membrane
YYK_RS00975	COG1131	(ABC) transporter
YYK_RS00980	COG2081	HI0933 family
YYK_RS00985	COG2723	6-phospho-beta-galactosidase activity
YYK_RS00995	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
YYK_RS01010	COG3959	Transketolase, thiamine diphosphate binding domain
YYK_RS01015	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
YYK_RS01020	COG0584	glycerophosphoryl diester phosphodiesterase
YYK_RS01025	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
YYK_RS01030	COG2222	sugar isomerase
YYK_RS01050	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
YYK_RS01055	COG1882	Formate acetyltransferase
YYK_RS01070	COG2910	NAD(P)H-binding
YYK_RS01095	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
YYK_RS01130	COG0363	glucosamine-6-phosphate deaminase activity
YYK_RS01140	COG2217	Heavy metal translocating P-type atpase
YYK_RS01145	COG2217	Heavy metal translocating P-type atpase
YYK_RS01150	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
YYK_RS01155	COG0681	Belongs to the peptidase S26 family
YYK_RS01175	COG0366	Alpha amylase catalytic
YYK_RS01190	COG1263	PTS System
YYK_RS01190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YYK_RS01195	COG2188	Transcriptional regulator
YYK_RS01210	COG1193	negative regulation of DNA recombination
YYK_RS01220	COG3118	belongs to the thioredoxin family
YYK_RS01225	COG0318	PFAM AMP-dependent synthetase and ligase
YYK_RS01230	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
YYK_RS01230	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
YYK_RS01250	COG1136	(ABC) transporter
YYK_RS01255	COG1115	amino acid carrier protein
YYK_RS01260	COG0668	transmembrane transport
YYK_RS01275	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
YYK_RS01280	COG0167	dihydroorotate dehydrogenase activity
YYK_RS01285	COG2843	Capsule synthesis protein
YYK_RS01290	COG0561	phosphatase activity
YYK_RS01305	COG1131	(ABC) transporter
YYK_RS01310	COG1309	transcriptional regulator
YYK_RS01315	COG1511	domain protein
YYK_RS01340	COG1346	cytolysis
YYK_RS01345	COG2116	formate transmembrane transporter activity
YYK_RS01350	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
YYK_RS01355	COG0433	COG0433 Predicted ATPase
YYK_RS01360	COG0494	nUDIX hydrolase
YYK_RS01385	COG0267	Belongs to the bacterial ribosomal protein bL33 family
YYK_RS01390	COG0333	Belongs to the bacterial ribosomal protein bL32 family
YYK_RS01395	COG0124	histidyl-tRNA synthetase
YYK_RS01400	COG1064	alcohol dehydrogenase
YYK_RS01405	COG1012	belongs to the aldehyde dehydrogenase family
YYK_RS01405	COG1454	alcohol dehydrogenase
YYK_RS01415	COG4988	ABC transporter
YYK_RS01420	COG1132	(ABC) transporter
YYK_RS01435	COG1129	ABC transporter
YYK_RS01440	COG0534	Mate efflux family protein
YYK_RS01445	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
YYK_RS01460	COG1304	FMN binding
YYK_RS01465	COG1132	(ABC) transporter
YYK_RS01470	COG1132	(ABC) transporter
YYK_RS01475	COG3830	Belongs to the UPF0237 family
YYK_RS01480	COG2848	UPF0210 protein
YYK_RS01485	COG0588	phosphoglycerate mutase activity
YYK_RS01490	COG1420	regulation of RNA biosynthetic process
YYK_RS01495	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
YYK_RS01500	COG0443	Heat shock 70 kDa protein
YYK_RS01505	COG0484	heat shock protein binding
YYK_RS01510	COG0095	Lipoate-protein ligase
YYK_RS01520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YYK_RS01525	COG0765	amino acid transport
YYK_RS01530	COG3655	Transcriptional regulator
YYK_RS01540	COG2217	Heavy metal translocating P-type atpase
YYK_RS01565	COG4475	Protein of unknown function (DUF436)
YYK_RS01595	COG4221	oxidoreductase activity
YYK_RS01600	COG1902	pentaerythritol trinitrate reductase activity
YYK_RS01600	COG0446	pyridine nucleotide-disulphide oxidoreductase
YYK_RS01605	COG1959	2 iron, 2 sulfur cluster binding
YYK_RS01625	COG0544	peptidyl-prolyl cis-trans isomerase activity
YYK_RS01645	COG3343	RNA polymerase activity
YYK_RS01650	COG0504	CTP synthase activity
YYK_RS01660	COG0191	fructose-bisphosphate aldolase activity
YYK_RS01665	COG0227	Belongs to the bacterial ribosomal protein bL28 family
YYK_RS01700	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
YYK_RS01705	COG0252	asparaginase activity
YYK_RS01720	COG0589	response to stress
YYK_RS01725	COG0436	Aminotransferase
YYK_RS01730	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
YYK_RS01735	COG1335	isochorismatase
YYK_RS01740	COG0335	large ribosomal subunit rRNA binding
YYK_RS01750	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
YYK_RS01755	COG0154	amidase activity
YYK_RS01760	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
YYK_RS01765	COG0232	Belongs to the dGTPase family. Type 2 subfamily
YYK_RS01770	COG1609	Transcriptional regulator
YYK_RS01775	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
YYK_RS01780	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
YYK_RS01790	COG3142	Participates in the control of copper homeostasis
YYK_RS01805	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
YYK_RS01810	COG1534	Rna-binding protein
YYK_RS01815	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
YYK_RS01820	COG1713	HD superfamily hydrolase involved in NAD metabolism
YYK_RS01835	COG0799	negative regulation of ribosome biogenesis
YYK_RS01840	COG2226	methyltransferase
YYK_RS01845	COG5290	Psort location Cytoplasmic, score
YYK_RS01855	COG0789	Transcriptional regulator
YYK_RS01860	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
YYK_RS01880	COG0242	peptide deformylase activity
YYK_RS01890	COG1640	4-alpha-glucanotransferase
YYK_RS01895	COG0058	SHG alpha-glucan phosphorylase activity
YYK_RS01910	COG2190	(PTS) system
YYK_RS01910	COG1263	PTS System
YYK_RS01910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YYK_RS01925	COG0217	transcriptional regulatory protein
YYK_RS01940	COG4720	Psort location CytoplasmicMembrane, score
YYK_RS01950	COG1054	Belongs to the UPF0176 family
YYK_RS01960	COG1122	ATPase activity
YYK_RS01975	COG0357	Ribosomal RNA small subunit methyltransferase G
YYK_RS01980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
YYK_RS01985	COG3331	DNA recombination
YYK_RS01990	COG4474	Belongs to the UPF0398 family
YYK_RS01995	COG3599	regulation of cell shape
YYK_RS02000	COG0116	Belongs to the methyltransferase superfamily
YYK_RS02010	COG1854	S-ribosylhomocysteine lyase activity
YYK_RS02015	COG1418	mRNA catabolic process
YYK_RS02025	COG1758	RNA polymerase activity
YYK_RS02030	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
YYK_RS02035	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
YYK_RS02040	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
YYK_RS02040	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
YYK_RS02045	COG0631	protein serine/threonine phosphatase activity
YYK_RS02050	COG2815	serine threonine protein kinase
YYK_RS02050	COG0515	serine threonine protein kinase
YYK_RS02075	COG1098	S1 RNA binding domain
YYK_RS02085	COG1739	Uncharacterized protein family UPF0029
YYK_RS02090	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
YYK_RS02170	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
YYK_RS02175	COG2137	regulation of response to DNA damage stimulus
YYK_RS02180	COG3557	Belongs to the UPF0374 family
YYK_RS02190	COG2188	Transcriptional regulator
YYK_RS02195	COG2188	Transcriptional regulator
YYK_RS02205	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YYK_RS02215	COG3716	PTS system mannose fructose sorbose family IID component
YYK_RS02225	COG2017	converts alpha-aldose to the beta-anomer
YYK_RS02240	COG0346	lactoylglutathione lyase activity
YYK_RS02290	COG1217	gtp-binding protein TYPA
YYK_RS02305	COG0681	Belongs to the peptidase S26 family
YYK_RS02335	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
YYK_RS02350	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
YYK_RS02355	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
YYK_RS02360	COG1799	cell septum assembly
YYK_RS02375	COG3599	regulation of cell shape
YYK_RS02390	COG0542	response to heat
YYK_RS02395	COG4703	Protein of unknown function (DUF1797)
YYK_RS02400	COG0765	amino acid transport
YYK_RS02410	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
YYK_RS02440	COG0789	Transcriptional regulator
YYK_RS02455	COG0826	peptidase U32
YYK_RS02470	COG4443	Transcriptional Coactivator p15 (PC4)
YYK_RS02475	COG1268	BioY protein
YYK_RS02480	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
YYK_RS02485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YYK_RS02490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YYK_RS02495	COG1136	(ABC) transporter
YYK_RS02500	COG0577	efflux transmembrane transporter activity
YYK_RS02515	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
YYK_RS02525	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
YYK_RS02535	COG3859	Proton-coupled thiamine transporter YuaJ
YYK_RS02555	COG0772	Belongs to the SEDS family
YYK_RS02560	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
YYK_RS02565	COG1595	DNA-templated transcription, initiation
YYK_RS02575	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
YYK_RS02580	COG0149	triose-phosphate isomerase activity
YYK_RS02590	COG1078	dGTPase activity
YYK_RS02605	COG2826	transposase and inactivated derivatives, IS30 family
YYK_RS02610	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
YYK_RS02620	COG1131	(ABC) transporter
YYK_RS02625	COG2188	Transcriptional regulator
YYK_RS02635	COG0205	6-phosphofructokinase activity
YYK_RS02640	COG0469	pyruvate kinase activity
YYK_RS02650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YYK_RS02655	COG2755	lipolytic protein G-D-S-L family
YYK_RS02655	COG0657	acetylesterase activity
YYK_RS02665	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
YYK_RS02670	COG0765	amino acid transport
YYK_RS02675	COG1126	abc transporter atp-binding protein
YYK_RS02680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YYK_RS02695	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
YYK_RS02700	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
YYK_RS02705	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
YYK_RS02720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YYK_RS02725	COG3022	response to hydroperoxide
YYK_RS02735	COG3944	biosynthesis protein
YYK_RS02745	COG4464	protein tyrosine phosphatase activity
YYK_RS02760	COG0438	transferase activity, transferring glycosyl groups
YYK_RS02775	COG1442	glycosyl transferase family 8
YYK_RS02775	COG1216	Glycosyl transferase, family 2
YYK_RS02780	COG1216	Glycosyl transferase, family 2
YYK_RS02780	COG1442	glycosyl transferase family 8
YYK_RS02805	COG2089	acid synthase
YYK_RS02820	COG1083	cytidylyl-transferase
YYK_RS02820	COG2755	lipolytic protein G-D-S-L family
YYK_RS02905	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
YYK_RS02910	COG0077	Prephenate dehydratase
YYK_RS02920	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
YYK_RS02925	COG0562	UDP-galactopyranose mutase
YYK_RS02930	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
YYK_RS02955	COG0436	Aminotransferase
YYK_RS02975	COG0534	Mate efflux family protein
YYK_RS02980	COG0251	oxidation-reduction process
YYK_RS02985	COG1660	Displays ATPase and GTPase activities
YYK_RS02990	COG0391	Required for morphogenesis under gluconeogenic growth conditions
YYK_RS02995	COG1481	regulation of sporulation
YYK_RS03010	COG0454	-acetyltransferase
YYK_RS03015	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
YYK_RS03020	COG0549	Belongs to the carbamate kinase family
YYK_RS03025	COG1288	antiporter activity
YYK_RS03030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
YYK_RS03035	COG3525	Glycosyl hydrolase, family 20, catalytic domain
YYK_RS03035	COG3064	Membrane
YYK_RS03035	COG3583	domain protein
YYK_RS03040	COG1438	arginine binding
YYK_RS03045	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
YYK_RS03050	COG0363	glucosamine-6-phosphate deaminase activity
YYK_RS03080	COG1696	Membrane protein involved in D-alanine export
YYK_RS03085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YYK_RS03090	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
YYK_RS03105	COG0435	Glutathione S-transferase
YYK_RS03110	COG1187	pseudouridine synthase activity
YYK_RS03115	COG0386	Belongs to the glutathione peroxidase family
YYK_RS03120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YYK_RS03125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YYK_RS03130	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
YYK_RS03135	COG1120	ATPase activity
YYK_RS03140	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
YYK_RS03145	COG0204	Acyl-transferase
YYK_RS03150	COG1596	polysaccharide export
YYK_RS03150	COG1555	photosystem II stabilization
YYK_RS03155	COG0658	competence protein
YYK_RS03155	COG2333	competence protein COMEC
YYK_RS03165	COG0517	IMP dehydrogenase activity
YYK_RS03180	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
YYK_RS03185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
YYK_RS03190	COG0470	DNA polymerase III
YYK_RS03195	COG4467	Involved in initiation control of chromosome replication
YYK_RS03205	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
YYK_RS03215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
YYK_RS03220	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
YYK_RS03225	COG1393	Belongs to the ArsC family
YYK_RS03235	COG0708	Exodeoxyribonuclease III
YYK_RS03245	COG0531	amino acid
YYK_RS03295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YYK_RS03300	COG4684	Psort location CytoplasmicMembrane, score
YYK_RS03305	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
YYK_RS03315	COG2759	Belongs to the formate--tetrahydrofolate ligase family
YYK_RS03325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YYK_RS03330	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
YYK_RS03345	COG0732	type I restriction modification DNA specificity domain
YYK_RS03380	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
YYK_RS03385	COG1349	DNA-binding transcription factor activity
YYK_RS03395	COG1447	Phosphotransferase system cellobiose-specific component IIA
YYK_RS03400	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
YYK_RS03405	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
YYK_RS03410	COG1882	Formate acetyltransferase
YYK_RS03430	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
YYK_RS03435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
YYK_RS03440	COG0446	pyridine nucleotide-disulphide oxidoreductase
YYK_RS03450	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
YYK_RS03455	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
YYK_RS03460	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
YYK_RS03465	COG0346	lactoylglutathione lyase activity
YYK_RS03475	COG1164	Oligoendopeptidase f
YYK_RS03490	COG0210	DNA helicase
YYK_RS03505	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
YYK_RS03520	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
YYK_RS03535	COG1122	ATPase activity
YYK_RS03540	COG1122	ATPase activity
YYK_RS03545	COG1011	Hydrolase
YYK_RS03575	COG1131	(ABC) transporter
YYK_RS03605	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
YYK_RS03610	COG1074	ATP-dependent DNA helicase activity
YYK_RS03620	COG0187	DNA topoisomerase II activity
YYK_RS03645	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
YYK_RS03655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
YYK_RS03675	COG0539	negative regulation of cytoplasmic translation
YYK_RS03700	COG1104	cysteine desulfurase activity
YYK_RS03705	COG0301	tRNA thio-modification
YYK_RS03710	COG1114	Component of the transport system for branched-chain amino acids
YYK_RS03715	COG0261	This protein binds to 23S rRNA in the presence of protein L20
YYK_RS03720	COG0211	Belongs to the bacterial ribosomal protein bL27 family
YYK_RS03740	COG0564	pseudouridine synthase activity
YYK_RS03745	COG2824	Alkylphosphonate utilization operon protein PhnA
YYK_RS03755	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
YYK_RS03760	COG0540	Belongs to the ATCase OTCase family
YYK_RS03765	COG0505	Belongs to the CarA family
YYK_RS03775	COG2521	methyltransferase
YYK_RS03775	COG2136	Putative SAM-dependent methyltransferase
YYK_RS03780	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
YYK_RS03790	COG0228	four-way junction DNA binding
YYK_RS03805	COG1132	(ABC) transporter
YYK_RS03810	COG0726	polysaccharide deacetylase
YYK_RS03815	COG0460	homoserine dehydrogenase
YYK_RS03820	COG0083	homoserine kinase activity
YYK_RS03825	COG0812	UDP-N-acetylmuramate dehydrogenase activity
YYK_RS03830	COG3842	ATPase activity
YYK_RS03835	COG1176	ABC-type spermidine putrescine transport system, permease component I
YYK_RS03840	COG1177	transmembrane transport
YYK_RS03850	COG0038	chloride channel
YYK_RS03865	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
YYK_RS03870	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
YYK_RS03885	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
YYK_RS03890	COG0336	Belongs to the RNA methyltransferase TrmD family
YYK_RS03895	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
YYK_RS03900	COG1349	DNA-binding transcription factor activity
YYK_RS03905	COG1105	Belongs to the carbohydrate kinase PfkB family
YYK_RS03910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
YYK_RS03910	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YYK_RS03910	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YYK_RS03920	COG1307	EDD domain protein, DegV family
YYK_RS03925	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
YYK_RS03930	COG0617	tRNA 3'-terminal CCA addition
YYK_RS03935	COG0488	(ABC) transporter
YYK_RS03945	COG1940	carbohydrate kinase activity
YYK_RS03960	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
YYK_RS03965	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
YYK_RS03975	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
YYK_RS03995	COG0481	GTPase activity
YYK_RS04020	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
YYK_RS04025	COG2890	protein-(glutamine-N5) methyltransferase activity
YYK_RS04030	COG0009	L-threonylcarbamoyladenylate synthase
YYK_RS04040	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
YYK_RS04050	COG0741	lytic transglycosylase activity
YYK_RS04055	COG4221	oxidoreductase activity
YYK_RS04080	COG1401	restriction endodeoxyribonuclease activity
YYK_RS04095	COG2188	Transcriptional regulator
YYK_RS04100	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
YYK_RS04105	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
YYK_RS04120	COG1660	Displays ATPase and GTPase activities
YYK_RS04135	COG4974	Belongs to the 'phage' integrase family
YYK_RS04150	COG0745	RESPONSE REGULATOR receiver
YYK_RS04170	COG1136	(ABC) transporter
YYK_RS04210	COG2382	esterase
YYK_RS04220	COG2207	Transcriptional regulator
YYK_RS04220	COG3708	Transcriptional regulator
YYK_RS04225	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
YYK_RS04230	COG0647	UMP catabolic process
YYK_RS04235	COG0222	ribosome binding
YYK_RS04240	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
YYK_RS04245	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
YYK_RS04250	COG0758	DNA mediated transformation
YYK_RS04255	COG0110	maltose O-acetyltransferase activity
YYK_RS04260	COG1937	Protein conserved in bacteria
YYK_RS04270	COG0446	pyridine nucleotide-disulphide oxidoreductase
YYK_RS04280	COG1272	protein, Hemolysin III
YYK_RS04290	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
YYK_RS04295	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
YYK_RS04310	COG0737	Belongs to the 5'-nucleotidase family
YYK_RS04320	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
YYK_RS04325	COG0463	Glycosyl transferase, family 2
YYK_RS04335	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
YYK_RS04340	COG0284	orotidine-5'-phosphate decarboxylase activity
YYK_RS04345	COG0167	dihydroorotate dehydrogenase activity
YYK_RS04370	COG0297	glycogen (starch) synthase activity
YYK_RS04380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YYK_RS04385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YYK_RS04400	COG3583	domain protein
YYK_RS04425	COG1126	abc transporter atp-binding protein
YYK_RS04435	COG0488	(ABC) transporter
YYK_RS04440	COG2873	o-acetylhomoserine
YYK_RS04465	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
YYK_RS04465	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
YYK_RS04475	COG3711	transcriptional antiterminator
YYK_RS04480	COG3684	Belongs to the aldolase LacD family
YYK_RS04485	COG1105	Belongs to the carbohydrate kinase PfkB family
YYK_RS04490	COG1105	Belongs to the carbohydrate kinase PfkB family
YYK_RS04495	COG0698	ribose 5-phosphate isomerase
YYK_RS04500	COG0698	ribose 5-phosphate isomerase
YYK_RS04510	COG1349	DNA-binding transcription factor activity
YYK_RS04540	COG1396	sequence-specific DNA binding
YYK_RS04545	COG1194	a g-specific adenine glycosylase
YYK_RS04555	COG1132	(ABC) transporter
YYK_RS04565	COG0280	phosphate acetyltransferase
YYK_RS04570	COG0564	pseudouridine synthase activity
YYK_RS04575	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
YYK_RS04580	COG2357	RelA SpoT domain protein
YYK_RS04585	COG4116	CYTH
YYK_RS04595	COG1104	cysteine desulfurase activity
YYK_RS04610	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
YYK_RS04615	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
YYK_RS04625	COG3764	Sortase (surface protein transpeptidase)
YYK_RS04630	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
YYK_RS04635	COG0039	L-malate dehydrogenase activity
YYK_RS04640	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
YYK_RS04645	COG1079	Belongs to the binding-protein-dependent transport system permease family
YYK_RS04650	COG4603	Belongs to the binding-protein-dependent transport system permease family
YYK_RS04655	COG3845	ABC transporter
YYK_RS04660	COG1744	ABC transporter substrate-binding protein PnrA-like
YYK_RS04665	COG0295	cytidine deaminase activity
YYK_RS04670	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
YYK_RS04675	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
YYK_RS04680	COG2813	Specifically methylates the guanine in position
YYK_RS04685	COG1072	(Pantothenic acid kinase))
YYK_RS04705	COG5002	protein histidine kinase activity
YYK_RS04710	COG0745	RESPONSE REGULATOR receiver
YYK_RS04725	COG0704	Plays a role in the regulation of phosphate uptake
YYK_RS04730	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
YYK_RS04735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
YYK_RS04740	COG0581	inorganic phosphate transmembrane transporter activity
YYK_RS04745	COG0573	inorganic phosphate transmembrane transporter activity
YYK_RS04755	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
YYK_RS04755	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
YYK_RS04760	COG0483	inositol monophosphate 1-phosphatase activity
YYK_RS04765	COG4476	Belongs to the UPF0223 family
YYK_RS04770	COG1393	Belongs to the ArsC family
YYK_RS04775	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
YYK_RS04780	COG0196	riboflavin kinase activity
YYK_RS04785	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
YYK_RS04845	COG0561	phosphatase activity
YYK_RS04850	COG2195	Cleaves the N-terminal amino acid of tripeptides
YYK_RS04885	COG3759	membrane
YYK_RS04890	COG1846	Transcriptional regulator
YYK_RS04905	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
YYK_RS04910	COG2610	gluconate transmembrane transporter activity
YYK_RS04930	COG0302	gtp cyclohydrolase
YYK_RS04935	COG1051	belongs to the nudix hydrolase family
YYK_RS04960	COG0072	phenylalanine-tRNA ligase activity
YYK_RS04960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
YYK_RS04990	COG1028	Short-chain dehydrogenase reductase Sdr
YYK_RS04995	COG1312	Catalyzes the dehydration of D-mannonate
YYK_RS05005	COG0800	Aldolase
YYK_RS05015	COG3250	beta-galactosidase activity
YYK_RS05025	COG2211	Major facilitator Superfamily
YYK_RS05040	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
YYK_RS05050	COG0355	proton-transporting ATP synthase activity, rotational mechanism
YYK_RS05055	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
YYK_RS05060	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
YYK_RS05065	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
YYK_RS05070	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
YYK_RS05075	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
YYK_RS05080	COG0356	it plays a direct role in the translocation of protons across the membrane
YYK_RS05090	COG1597	lipid kinase activity
YYK_RS05100	COG0701	Predicted permease
YYK_RS05105	COG3689	TIGRFAM TIGR03943 family protein
YYK_RS05110	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
YYK_RS05125	COG0552	protein localization to endoplasmic reticulum
YYK_RS05130	COG0561	phosphatase activity
YYK_RS05135	COG0561	phosphatase activity
YYK_RS05140	COG1196	nuclear chromosome segregation
YYK_RS05165	COG2826	transposase and inactivated derivatives, IS30 family
YYK_RS05180	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
YYK_RS05185	COG0538	isocitrate dehydrogenase activity
YYK_RS05190	COG0372	Belongs to the citrate synthase family
YYK_RS05195	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
YYK_RS05200	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
YYK_RS05205	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
YYK_RS05215	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
YYK_RS05220	COG1609	Transcriptional regulator
YYK_RS05235	COG5492	domain, Protein
YYK_RS05245	COG3716	PTS system mannose fructose sorbose family IID component
YYK_RS05255	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YYK_RS05260	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
YYK_RS05285	COG1028	Short-chain dehydrogenase reductase Sdr
YYK_RS05320	COG1476	TRANSCRIPTIONal
YYK_RS05345	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
YYK_RS05355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
YYK_RS05360	COG4122	O-methyltransferase activity
YYK_RS05385	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
YYK_RS05385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
YYK_RS05395	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
YYK_RS05400	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
YYK_RS05405	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
YYK_RS05410	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
YYK_RS05415	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
YYK_RS05415	COG1116	anion transmembrane transporter activity
YYK_RS05420	COG4120	Belongs to the binding-protein-dependent transport system permease family
YYK_RS05440	COG3684	Belongs to the aldolase LacD family
YYK_RS05450	COG3679	Belongs to the UPF0342 family
YYK_RS05455	COG0287	Prephenate dehydrogenase
YYK_RS05460	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
YYK_RS05465	COG0710	3-dehydroquinate dehydratase activity
YYK_RS05470	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
YYK_RS05475	COG1368	sulfuric ester hydrolase activity
YYK_RS05490	COG0291	Belongs to the bacterial ribosomal protein bL35 family
YYK_RS05500	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
YYK_RS05545	COG1216	Glycosyl transferase, family 2
YYK_RS05545	COG1442	glycosyl transferase family 8
YYK_RS05550	COG1442	glycosyl transferase family 8
YYK_RS05580	COG0463	Glycosyl transferase, family 2
YYK_RS05610	COG1091	dTDP-4-dehydrorhamnose reductase activity
YYK_RS05615	COG1088	dTDP-glucose 4,6-dehydratase activity
YYK_RS05630	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
YYK_RS05645	COG2384	SAM-dependent methyltransferase
YYK_RS05660	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
YYK_RS05675	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
YYK_RS05675	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
YYK_RS05680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
YYK_RS05690	COG0300	oxidoreductase activity
YYK_RS05695	COG1234	tRNA 3'-trailer cleavage
YYK_RS05705	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
YYK_RS05710	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
YYK_RS05720	COG2807	transmembrane transport
YYK_RS05725	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
YYK_RS05730	COG1702	phosphate starvation-inducible protein PhoH
YYK_RS05735	COG4479	Belongs to the UPF0346 family
YYK_RS05750	COG2996	Protein conserved in bacteria
YYK_RS05755	COG0233	cytoplasmic translational termination
YYK_RS05760	COG0528	UMP kinase activity
YYK_RS05765	COG2244	polysaccharide biosynthetic process
YYK_RS05770	COG0625	glutathione transferase activity
YYK_RS05795	COG0346	lactoylglutathione lyase activity
YYK_RS05800	COG1674	ftsk spoiiie
YYK_RS05800	COG0697	spore germination
YYK_RS05805	COG1621	beta-fructofuranosidase activity
YYK_RS05815	COG0395	ABC-type sugar transport system, permease component
YYK_RS05820	COG4209	transmembrane transport
YYK_RS05825	COG1609	Transcriptional regulator
YYK_RS05845	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
YYK_RS05860	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
YYK_RS05870	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
YYK_RS05880	COG1181	Belongs to the D-alanine--D-alanine ligase family
YYK_RS05885	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
YYK_RS05890	COG0768	penicillin binding
YYK_RS05900	COG0488	(ABC) transporter
YYK_RS05910	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
YYK_RS05920	COG0745	RESPONSE REGULATOR receiver
YYK_RS05925	COG1126	abc transporter atp-binding protein
YYK_RS05930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YYK_RS05935	COG0765	amino acid transport
YYK_RS05940	COG0765	amino acid transport
YYK_RS05945	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
YYK_RS05960	COG0438	transferase activity, transferring glycosyl groups
YYK_RS05975	COG1609	Transcriptional regulator
YYK_RS05985	COG0343	queuine tRNA-ribosyltransferase activity
YYK_RS05995	COG1832	CoA-binding protein
YYK_RS06005	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YYK_RS06005	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YYK_RS06020	COG1136	(ABC) transporter
YYK_RS06030	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
YYK_RS06050	COG1063	alcohol dehydrogenase
YYK_RS06055	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
YYK_RS06060	COG0557	exoribonuclease II activity
YYK_RS06070	COG0267	Belongs to the bacterial ribosomal protein bL33 family
YYK_RS06075	COG2814	Major facilitator Superfamily
YYK_RS06080	COG0237	dephospho-CoA kinase activity
YYK_RS06085	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
YYK_RS06090	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
YYK_RS06095	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
YYK_RS06105	COG1737	Transcriptional regulator
YYK_RS06115	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
YYK_RS06130	COG1132	(ABC) transporter
YYK_RS06135	COG1132	(ABC) transporter
YYK_RS06160	COG2177	Part of the ABC transporter FtsEX involved in
YYK_RS06165	COG2884	Cell division ATP-binding protein ftsE
YYK_RS06170	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
YYK_RS06175	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
YYK_RS06200	COG2826	transposase and inactivated derivatives, IS30 family
YYK_RS06230	COG2151	metal-sulfur cluster biosynthetic enzyme
YYK_RS06235	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
YYK_RS06240	COG0358	DNA primase activity
YYK_RS06245	COG1970	mechanosensitive ion channel activity
YYK_RS06250	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
YYK_RS06255	COG0828	Belongs to the bacterial ribosomal protein bS21 family
YYK_RS06265	COG0647	UMP catabolic process
YYK_RS06270	COG1051	belongs to the nudix hydrolase family
YYK_RS06280	COG0635	Involved in the biosynthesis of porphyrin-containing compound
YYK_RS06285	COG0058	SHG alpha-glucan phosphorylase activity
YYK_RS06290	COG0813	purine-nucleoside phosphorylase activity
YYK_RS06295	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
YYK_RS06305	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
YYK_RS06310	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
YYK_RS06315	COG0732	type I restriction modification DNA specificity domain
YYK_RS06335	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
YYK_RS06350	COG2268	Band 7 protein
YYK_RS06355	COG1704	LemA family
YYK_RS06365	COG1573	uracil-dna glycosylase
YYK_RS06400	COG2226	methyltransferase
YYK_RS06405	COG0488	(ABC) transporter
YYK_RS06410	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YYK_RS06425	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
YYK_RS06430	COG3442	glutamine amidotransferase
YYK_RS06445	COG2226	methyltransferase
YYK_RS06460	COG0488	(ABC) transporter
YYK_RS06495	COG3842	ATPase activity
YYK_RS06515	COG1263	PTS System
YYK_RS06515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YYK_RS06515	COG2190	(PTS) system
YYK_RS06520	COG3711	transcriptional antiterminator
YYK_RS06525	COG1293	RNA-binding protein homologous to eukaryotic snRNP
YYK_RS06530	COG3527	Alpha-acetolactate decarboxylase
YYK_RS06540	COG0628	permease
YYK_RS06545	COG2706	6-phosphogluconolactonase activity
YYK_RS06555	COG1011	Hydrolase
YYK_RS06600	COG0560	Phosphoserine phosphatase
YYK_RS06605	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
YYK_RS06610	COG0187	DNA topoisomerase II activity
YYK_RS06615	COG0693	protein deglycase activity
YYK_RS06620	COG0772	Belongs to the SEDS family
YYK_RS06635	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
YYK_RS06640	COG0716	FMN binding
YYK_RS06650	COG0287	Prephenate dehydrogenase
YYK_RS06650	COG1605	Chorismate mutase
YYK_RS06655	COG0038	chloride channel
YYK_RS06665	COG0737	Belongs to the 5'-nucleotidase family
YYK_RS06670	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
YYK_RS06675	COG1466	dna polymerase III delta subunit
YYK_RS06710	COG0683	leucine binding
YYK_RS06725	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
YYK_RS06730	COG0366	Alpha amylase catalytic
YYK_RS06740	COG0395	ABC-type sugar transport system, permease component
YYK_RS06745	COG1175	transmembrane transport
YYK_RS06750	COG1653	transport
YYK_RS06760	COG2207	Transcriptional regulator
YYK_RS06765	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
YYK_RS06770	COG0626	cystathionine gamma-synthase activity
YYK_RS06790	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
YYK_RS06795	COG2827	Endonuclease containing a URI domain
YYK_RS06820	COG0640	Transcriptional regulator
YYK_RS06825	COG0513	Belongs to the DEAD box helicase family
YYK_RS06830	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
YYK_RS06870	COG0494	nUDIX hydrolase
YYK_RS06875	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
YYK_RS06890	COG1028	Short-chain dehydrogenase reductase Sdr
YYK_RS06920	COG0577	efflux transmembrane transporter activity
YYK_RS06925	COG1136	(ABC) transporter
YYK_RS06930	COG2205	protein histidine kinase activity
YYK_RS06945	COG0436	Aminotransferase
YYK_RS06955	COG1174	glycine betaine transport
YYK_RS06960	COG1125	glycine betaine transport
YYK_RS06960	COG0517	IMP dehydrogenase activity
YYK_RS06980	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
YYK_RS06985	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
YYK_RS06990	COG1482	cell wall glycoprotein biosynthetic process
YYK_RS07015	COG3091	SprT-like family
YYK_RS07025	COG0656	L-ascorbic acid biosynthetic process
YYK_RS07030	COG4708	membrane
YYK_RS07035	COG2246	polysaccharide biosynthetic process
YYK_RS07045	COG0024	Methionine aminopeptidase
YYK_RS07055	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
YYK_RS07060	COG2249	NAD(P)H dehydrogenase (quinone) activity
YYK_RS07065	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
YYK_RS07070	COG2131	deaminase
YYK_RS07080	COG1363	Peptidase, m42
YYK_RS07095	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
YYK_RS07100	COG1956	GAF domain-containing protein
YYK_RS07110	COG1695	Transcriptional regulator
YYK_RS07125	COG0513	Belongs to the DEAD box helicase family
YYK_RS07130	COG0726	polysaccharide deacetylase
YYK_RS07150	COG0183	Belongs to the thiolase family
YYK_RS07155	COG3425	synthase
YYK_RS07185	COG0776	regulation of translation
YYK_RS07195	COG2755	lipolytic protein G-D-S-L family
YYK_RS07200	COG1307	EDD domain protein, DegV family
YYK_RS07205	COG0497	DNA recombination
YYK_RS07210	COG1438	arginine binding
YYK_RS07215	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
YYK_RS07225	COG1722	exodeoxyribonuclease VII activity
YYK_RS07230	COG1570	exodeoxyribonuclease VII activity
YYK_RS07235	COG2321	neutral zinc metallopeptidase
YYK_RS07240	COG1755	Isoprenylcysteine carboxyl methyltransferase
YYK_RS07245	COG5002	protein histidine kinase activity
YYK_RS07250	COG0745	RESPONSE REGULATOR receiver
YYK_RS07275	COG1227	inorganic diphosphatase activity
YYK_RS07285	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
YYK_RS07290	COG1253	flavin adenine dinucleotide binding
YYK_RS07295	COG1119	ATPase activity
YYK_RS07300	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
YYK_RS07310	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
YYK_RS07315	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
YYK_RS07330	COG4470	Protein conserved in bacteria
YYK_RS07335	COG3480	Lon protease (S16) C-terminal proteolytic domain
YYK_RS07340	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
YYK_RS07345	COG0742	ribosomal rna small subunit methyltransferase
YYK_RS07355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
YYK_RS07360	COG4483	Protein conserved in bacteria
YYK_RS07365	COG2197	response regulator
YYK_RS07370	COG2203	Gaf domain
YYK_RS07370	COG4585	Histidine kinase
YYK_RS07375	COG0842	Transport permease protein
YYK_RS07380	COG1131	(ABC) transporter
YYK_RS07395	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
YYK_RS07410	COG0671	phosphoesterase, PA-phosphatase related
YYK_RS07415	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
YYK_RS07430	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
YYK_RS07435	COG1187	pseudouridine synthase activity
YYK_RS07440	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
YYK_RS07445	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
YYK_RS07450	COG0582	viral genome integration into host DNA
YYK_RS07470	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
YYK_RS07475	COG3763	UPF0154 protein
YYK_RS07485	COG3579	cysteine-type endopeptidase activity
YYK_RS07500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YYK_RS07505	COG1254	Belongs to the acylphosphatase family
YYK_RS07515	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YYK_RS07520	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
YYK_RS07530	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
YYK_RS07540	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
YYK_RS07555	COG1160	GTP binding
YYK_RS07565	COG1484	DNA-dependent DNA replication
YYK_RS07575	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
YYK_RS07580	COG0628	permease
YYK_RS07585	COG0745	RESPONSE REGULATOR receiver
YYK_RS07590	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
YYK_RS07600	COG0492	ferredoxin-NADP+ reductase activity
YYK_RS07610	COG0513	Belongs to the DEAD box helicase family
YYK_RS07620	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YYK_RS07625	COG0768	penicillin binding
YYK_RS07635	COG0275	rRNA processing
YYK_RS07685	COG4939	FMN-binding domain protein
YYK_RS07695	COG1252	NADH dehydrogenase
YYK_RS07710	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
YYK_RS07715	COG0569	domain protein
YYK_RS07720	COG0534	Mate efflux family protein
YYK_RS07730	COG4224	UPF0291 protein
YYK_RS07735	COG0751	glycine-tRNA ligase activity
YYK_RS07760	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
YYK_RS07765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
YYK_RS07770	COG1464	Belongs to the NlpA lipoprotein family
YYK_RS07775	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
YYK_RS07780	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
YYK_RS07785	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
YYK_RS07790	COG2252	PERMEase
YYK_RS07795	COG0561	phosphatase activity
YYK_RS07805	COG3715	PTS system
YYK_RS07810	COG3716	PTS system mannose fructose sorbose family IID component
YYK_RS07835	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
YYK_RS07880	COG0439	Biotin carboxylase
YYK_RS07900	COG1028	Short-chain dehydrogenase reductase Sdr
YYK_RS07905	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
YYK_RS07910	COG2070	2-Nitropropane dioxygenase
YYK_RS07920	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
YYK_RS07930	COG1024	Enoyl-CoA hydratase
YYK_RS07935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YYK_RS07940	COG0527	aspartate kinase activity
YYK_RS07950	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
YYK_RS07955	COG0736	holo-[acyl-carrier-protein] synthase activity
YYK_RS07960	COG0653	protein targeting
YYK_RS07970	COG1940	carbohydrate kinase activity
YYK_RS07975	COG2190	(PTS) system
YYK_RS07975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YYK_RS07975	COG1263	PTS System
YYK_RS07980	COG1621	beta-fructofuranosidase activity
YYK_RS07985	COG1609	Transcriptional regulator
YYK_RS07990	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
YYK_RS08005	COG0006	proline dipeptidase activity
YYK_RS08010	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YYK_RS08030	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
YYK_RS08035	COG0629	single-stranded DNA binding
YYK_RS08045	COG2826	transposase and inactivated derivatives, IS30 family
YYK_RS08050	COG0095	Lipoate-protein ligase
YYK_RS08065	COG0508	dehydrogenase complex catalyzes the overall conversion of
YYK_RS08070	COG0022	dehydrogenase e1 component
YYK_RS08070	COG0508	dehydrogenase complex catalyzes the overall conversion of
YYK_RS08075	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
YYK_RS08080	COG2860	membrane
YYK_RS08095	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
YYK_RS08100	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
YYK_RS08110	COG2740	Nucleic-acid-binding protein implicated in transcription termination
YYK_RS08115	COG0195	Participates in both transcription termination and antitermination
YYK_RS08125	COG0220	tRNA (guanine-N7-)-methyltransferase activity
YYK_RS08135	COG4473	ABC transporter
YYK_RS08140	COG1131	(ABC) transporter
YYK_RS08145	COG0537	adenosine 5'-monophosphoramidase activity
YYK_RS08155	COG1316	TRANSCRIPTIONal
YYK_RS08165	COG0802	atpase or kinase
YYK_RS08170	COG1461	Dihydroxyacetone kinase
YYK_RS08185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YYK_RS08190	COG0601	transmembrane transport
YYK_RS08195	COG4608	Belongs to the ABC transporter superfamily
YYK_RS08210	COG1686	Belongs to the peptidase S11 family
YYK_RS08225	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
YYK_RS08230	COG0719	Fe-S assembly protein
YYK_RS08240	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YYK_RS08245	COG4862	establishment of competence for transformation
YYK_RS08250	COG1968	undecaprenyl-diphosphatase activity
YYK_RS08255	COG0765	amino acid transport
YYK_RS08275	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
YYK_RS08280	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
YYK_RS08285	COG0440	acetolactate synthase activity
YYK_RS08290	COG0028	Belongs to the TPP enzyme family
YYK_RS08310	COG0129	dihydroxy-acid dehydratase activity
YYK_RS08320	COG2151	metal-sulfur cluster biosynthetic enzyme
YYK_RS08340	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
YYK_RS08355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YYK_RS08380	COG3842	ATPase activity
YYK_RS08390	COG4753	response regulator
YYK_RS08390	COG2207	Transcriptional regulator
YYK_RS08395	COG2972	Histidine kinase
YYK_RS08410	COG1653	transport
YYK_RS08415	COG0395	ABC-type sugar transport system, permease component
YYK_RS08420	COG1175	transmembrane transport
YYK_RS08435	COG0383	alpha-mannosidase activity
YYK_RS08455	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
YYK_RS08475	COG1045	serine acetyltransferase
YYK_RS08480	COG1185	polyribonucleotide nucleotidyltransferase activity
YYK_RS08500	COG1263	PTS System
YYK_RS08500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YYK_RS08510	COG1737	Transcriptional regulator
YYK_RS08515	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
YYK_RS08535	COG1187	pseudouridine synthase activity
YYK_RS08555	COG0242	peptide deformylase activity
YYK_RS08565	COG0066	3-isopropylmalate dehydratase activity
YYK_RS08590	COG2309	aminopeptidase activity
YYK_RS08605	COG2176	DNA-directed DNA polymerase activity
YYK_RS08610	COG2376	Dihydroxyacetone kinase
YYK_RS08620	COG2376	Dihydroxyacetone kinase
YYK_RS08625	COG1461	Dihydroxyacetone kinase
YYK_RS08630	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
YYK_RS08635	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
YYK_RS08640	COG0442	prolyl-tRNA aminoacylation
YYK_RS08650	COG4589	Belongs to the CDS family
YYK_RS08655	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
YYK_RS08660	COG1862	Preprotein translocase
YYK_RS08670	COG2918	glutathione biosynthetic process
YYK_RS08670	COG1181	Belongs to the D-alanine--D-alanine ligase family
YYK_RS08680	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
YYK_RS08685	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
YYK_RS08695	COG3201	nicotinamide mononucleotide transporter
YYK_RS08700	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
YYK_RS08710	COG4463	regulation of RNA biosynthetic process
YYK_RS08725	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
YYK_RS08760	COG0267	Belongs to the bacterial ribosomal protein bL33 family
YYK_RS08765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
YYK_RS08770	COG0492	ferredoxin-NADP+ reductase activity
YYK_RS08775	COG0564	pseudouridine synthase activity
YYK_RS08780	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
YYK_RS08800	COG1564	THIamine pyrophosphokinase
YYK_RS08810	COG1162	GTPase activity
YYK_RS08860	COG4115	mRNA cleavage
YYK_RS08895	COG0084	hydrolase, TatD family'
YYK_RS08905	COG1847	R3H domain protein
YYK_RS08915	COG0594	ribonuclease P activity
YYK_RS08920	COG0165	Argininosuccinate lyase
YYK_RS08925	COG0137	argininosuccinate synthase activity
YYK_RS08935	COG1827	regulation of RNA biosynthetic process
YYK_RS08950	COG2040	homocysteine
YYK_RS08955	COG0833	amino acid
YYK_RS09000	COG0756	dUTP diphosphatase activity
YYK_RS09005	COG1132	(ABC) transporter
YYK_RS09010	COG1132	(ABC) transporter
YYK_RS09020	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
YYK_RS09025	COG1210	Utp--glucose-1-phosphate uridylyltransferase
YYK_RS09030	COG0705	Rhomboid family
YYK_RS09035	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
YYK_RS09040	COG1473	amidohydrolase
YYK_RS09045	COG2171	N-acyltransferase activity
YYK_RS09060	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
YYK_RS09080	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
YYK_RS09105	COG3623	hexulose-6-phosphate isomerase
YYK_RS09130	COG1523	belongs to the glycosyl hydrolase 13 family
YYK_RS09135	COG1609	Transcriptional regulator
YYK_RS09140	COG1126	abc transporter atp-binding protein
YYK_RS09145	COG0765	amino acid transport
YYK_RS09150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YYK_RS09155	COG3942	CHAP domain
YYK_RS09160	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
YYK_RS09170	COG1447	Phosphotransferase system cellobiose-specific component IIA
YYK_RS09180	COG3711	transcriptional antiterminator
YYK_RS09180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
YYK_RS09190	COG2723	6-phospho-beta-galactosidase activity
YYK_RS09195	COG1486	melibiose metabolic process
YYK_RS09205	COG3590	peptidase
YYK_RS09210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
YYK_RS09215	COG1321	iron dependent repressor
YYK_RS09215	COG1108	ABC-type Mn2 Zn2 transport systems permease components
YYK_RS09220	COG1121	(ABC) transporter
YYK_RS09230	COG0803	Belongs to the bacterial solute-binding protein 9 family
YYK_RS09265	COG1490	D-aminoacyl-tRNA deacylase activity
YYK_RS09275	COG0737	Belongs to the 5'-nucleotidase family
YYK_RS09330	COG1385	rRNA (uridine-N3-)-methyltransferase activity
YYK_RS09355	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
YYK_RS09380	COG0737	Belongs to the 5'-nucleotidase family
YYK_RS09390	COG1328	CTP reductase activity
YYK_RS09420	COG1438	arginine binding
YYK_RS09425	COG0018	arginyl-trna synthetase
YYK_RS09445	COG1640	4-alpha-glucanotransferase
YYK_RS09450	COG2182	Extracellular solute-binding protein
YYK_RS09455	COG1175	transmembrane transport
YYK_RS09460	COG3833	ABC-type maltose transport systems, permease component
YYK_RS09465	COG5521	maltodextrose utilization protein MalA
YYK_RS09470	COG1609	Transcriptional regulator
YYK_RS09475	COG1523	belongs to the glycosyl hydrolase 13 family
YYK_RS09480	COG1780	Probably involved in ribonucleotide reductase function
YYK_RS09485	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
YYK_RS09490	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
YYK_RS09495	COG2153	protein acetylation
YYK_RS09500	COG4989	oxidoreductase activity
YYK_RS09505	COG1216	Glycosyl transferase, family 2
YYK_RS09510	COG1472	Belongs to the glycosyl hydrolase 3 family
YYK_RS09550	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
YYK_RS09565	COG0305	Participates in initiation and elongation during chromosome replication
YYK_RS09570	COG0359	binds to the 23S rRNA
YYK_RS09580	COG0445	tRNA wobble uridine modification
YYK_RS09595	COG1051	belongs to the nudix hydrolase family
YYK_RS09600	COG1733	regulation of RNA biosynthetic process
YYK_RS09610	COG0482	sulfurtransferase activity
YYK_RS09615	COG1760	l-serine dehydratase
YYK_RS09620	COG1760	l-serine dehydratase
YYK_RS09630	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
YYK_RS09635	COG1122	ATPase activity
YYK_RS09640	COG1122	ATPase activity
YYK_RS09645	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
YYK_RS09650	COG1426	Protein conserved in bacteria
YYK_RS09655	COG0612	Peptidase, M16
YYK_RS09660	COG0612	Peptidase, M16
YYK_RS09670	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
YYK_RS09675	COG0517	IMP dehydrogenase activity
YYK_RS09675	COG0516	GMP reductase activity
YYK_RS09685	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
YYK_RS09690	COG0488	(ABC) transporter
YYK_RS09720	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
YYK_RS09725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YYK_RS09730	COG1475	DNA binding
YYK_RS09740	COG0582	viral genome integration into host DNA