locus-tag	class	description
CRH08_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CRH08_RS00010	COG0592	DNA-directed DNA polymerase activity
CRH08_RS00030	COG0012	GTP binding
CRH08_RS00035	COG0193	aminoacyl-tRNA hydrolase activity
CRH08_RS00040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CRH08_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CRH08_RS00065	COG0037	tRNA processing
CRH08_RS00075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CRH08_RS00185	COG1792	Involved in formation and maintenance of cell shape
CRH08_RS00200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CRH08_RS00205	COG0436	Aminotransferase
CRH08_RS00210	COG1381	Involved in DNA repair and RecF pathway recombination
CRH08_RS00215	COG0416	fatty acid biosynthetic process
CRH08_RS00220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CRH08_RS00230	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CRH08_RS00245	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CRH08_RS00250	COG0138	bifunctional purine biosynthesis protein purh
CRH08_RS00275	COG0151	Belongs to the GarS family
CRH08_RS00280	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CRH08_RS00295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CRH08_RS00335	COG1132	(ABC) transporter
CRH08_RS00340	COG2255	four-way junction helicase activity
CRH08_RS00350	COG0546	phosphoglycolate phosphatase activity
CRH08_RS00360	COG0285	dihydrofolate synthase activity
CRH08_RS00375	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CRH08_RS00380	COG0632	four-way junction helicase activity
CRH08_RS00385	COG0519	Catalyzes the synthesis of GMP from XMP
CRH08_RS00400	COG1393	Belongs to the ArsC family
CRH08_RS00405	COG4472	Bacterial protein of unknown function (DUF965)
CRH08_RS00410	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CRH08_RS00415	COG3906	Belongs to the UPF0473 family
CRH08_RS00430	COG0051	transcription antitermination factor activity, RNA binding
CRH08_RS00435	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CRH08_RS00440	COG0088	Forms part of the polypeptide exit tunnel
CRH08_RS00445	COG0089	rRNA binding
CRH08_RS00450	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CRH08_RS00455	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CRH08_RS00460	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CRH08_RS00465	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CRH08_RS00470	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CRH08_RS00475	COG0255	Belongs to the universal ribosomal protein uL29 family
CRH08_RS00480	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CRH08_RS00485	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CRH08_RS00490	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CRH08_RS00495	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CRH08_RS00500	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CRH08_RS00510	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CRH08_RS00520	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CRH08_RS00525	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CRH08_RS00530	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CRH08_RS00535	COG1841	ribosomal large subunit assembly
CRH08_RS00545	COG0201	protein transport
CRH08_RS00550	COG0563	adenylate kinase activity
CRH08_RS00555	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CRH08_RS00560	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CRH08_RS00565	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CRH08_RS00575	COG0202	RNA polymerase activity
CRH08_RS00675	COG0582	viral genome integration into host DNA
CRH08_RS00685	COG2946	Replication initiation factor
CRH08_RS00735	COG1121	(ABC) transporter
CRH08_RS00740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CRH08_RS00745	COG3443	Belongs to the bacterial solute-binding protein 9 family
CRH08_RS00745	COG0803	Belongs to the bacterial solute-binding protein 9 family
CRH08_RS00770	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CRH08_RS00775	COG0085	RNA polymerase activity
CRH08_RS00780	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CRH08_RS00790	COG1619	proteins homologs of microcin C7 resistance protein MccF
CRH08_RS00795	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CRH08_RS00800	COG1459	type II secretion system
CRH08_RS00805	COG4537	Required for transformation and DNA binding
CRH08_RS00835	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CRH08_RS00850	COG0285	dihydrofolate synthase activity
CRH08_RS00855	COG1363	Peptidase, m42
CRH08_RS00865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CRH08_RS00875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CRH08_RS00900	COG0459	protein refolding
CRH08_RS00910	COG0049	tRNA binding
CRH08_RS00915	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CRH08_RS00920	COG3590	peptidase
CRH08_RS00930	COG0126	phosphoglycerate kinase activity
CRH08_RS00940	COG0789	Transcriptional regulator
CRH08_RS00945	COG0174	glutamine synthetase
CRH08_RS00960	COG1214	PFAM Peptidase M22, glycoprotease
CRH08_RS00970	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CRH08_RS00975	COG2207	Transcriptional regulator
CRH08_RS00985	COG1175	transmembrane transport
CRH08_RS00990	COG0395	ABC-type sugar transport system, permease component
CRH08_RS01010	COG2855	membrane
CRH08_RS01020	COG1131	(ABC) transporter
CRH08_RS01030	COG2081	HI0933 family
CRH08_RS01035	COG2723	6-phospho-beta-galactosidase activity
CRH08_RS01045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRH08_RS01060	COG3959	Transketolase, thiamine diphosphate binding domain
CRH08_RS01065	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CRH08_RS01070	COG0584	glycerophosphoryl diester phosphodiesterase
CRH08_RS01075	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CRH08_RS01080	COG2222	sugar isomerase
CRH08_RS01110	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CRH08_RS01120	COG3942	CHAP domain
CRH08_RS01125	COG1882	Formate acetyltransferase
CRH08_RS01140	COG2910	NAD(P)H-binding
CRH08_RS01200	COG0363	glucosamine-6-phosphate deaminase activity
CRH08_RS01205	COG2217	Heavy metal translocating P-type atpase
CRH08_RS01215	COG2217	Heavy metal translocating P-type atpase
CRH08_RS01220	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CRH08_RS01225	COG0681	Belongs to the peptidase S26 family
CRH08_RS01245	COG0366	Alpha amylase catalytic
CRH08_RS01250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRH08_RS01250	COG1263	PTS System
CRH08_RS01255	COG2188	Transcriptional regulator
CRH08_RS01275	COG1193	negative regulation of DNA recombination
CRH08_RS01340	COG3118	belongs to the thioredoxin family
CRH08_RS01350	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CRH08_RS01350	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CRH08_RS01390	COG1115	amino acid carrier protein
CRH08_RS01455	COG0668	transmembrane transport
CRH08_RS01470	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CRH08_RS01475	COG0167	dihydroorotate dehydrogenase activity
CRH08_RS01480	COG2843	Capsule synthesis protein
CRH08_RS01485	COG0561	phosphatase activity
CRH08_RS01500	COG1131	(ABC) transporter
CRH08_RS01505	COG1309	transcriptional regulator
CRH08_RS01545	COG1346	cytolysis
CRH08_RS01550	COG2116	formate transmembrane transporter activity
CRH08_RS01555	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CRH08_RS01560	COG0433	COG0433 Predicted ATPase
CRH08_RS01565	COG0494	nUDIX hydrolase
CRH08_RS01590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CRH08_RS01595	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CRH08_RS01600	COG0124	histidyl-tRNA synthetase
CRH08_RS01605	COG1064	alcohol dehydrogenase
CRH08_RS01610	COG1454	alcohol dehydrogenase
CRH08_RS01610	COG1012	belongs to the aldehyde dehydrogenase family
CRH08_RS01630	COG1132	(ABC) transporter
CRH08_RS01640	COG0534	Mate efflux family protein
CRH08_RS01645	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CRH08_RS01660	COG1304	FMN binding
CRH08_RS01665	COG1132	(ABC) transporter
CRH08_RS01670	COG1132	(ABC) transporter
CRH08_RS01675	COG3830	Belongs to the UPF0237 family
CRH08_RS01680	COG2848	UPF0210 protein
CRH08_RS01685	COG0588	phosphoglycerate mutase activity
CRH08_RS01690	COG1420	regulation of RNA biosynthetic process
CRH08_RS01695	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CRH08_RS01700	COG0443	Heat shock 70 kDa protein
CRH08_RS01705	COG0484	heat shock protein binding
CRH08_RS01715	COG0095	Lipoate-protein ligase
CRH08_RS01725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRH08_RS01730	COG0765	amino acid transport
CRH08_RS01745	COG3655	Transcriptional regulator
CRH08_RS01755	COG2217	Heavy metal translocating P-type atpase
CRH08_RS01780	COG4475	Protein of unknown function (DUF436)
CRH08_RS01805	COG4221	oxidoreductase activity
CRH08_RS01810	COG0446	pyridine nucleotide-disulphide oxidoreductase
CRH08_RS01810	COG1902	pentaerythritol trinitrate reductase activity
CRH08_RS01830	COG0544	peptidyl-prolyl cis-trans isomerase activity
CRH08_RS01860	COG3343	RNA polymerase activity
CRH08_RS01865	COG0504	CTP synthase activity
CRH08_RS01875	COG0191	fructose-bisphosphate aldolase activity
CRH08_RS01880	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CRH08_RS01915	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CRH08_RS01945	COG0436	Aminotransferase
CRH08_RS01950	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CRH08_RS01955	COG1335	isochorismatase
CRH08_RS01965	COG0335	large ribosomal subunit rRNA binding
CRH08_RS01975	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CRH08_RS01980	COG0154	amidase activity
CRH08_RS01985	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CRH08_RS01995	COG1609	Transcriptional regulator
CRH08_RS02000	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CRH08_RS02005	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CRH08_RS02020	COG3142	Participates in the control of copper homeostasis
CRH08_RS02035	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CRH08_RS02045	COG1534	Rna-binding protein
CRH08_RS02050	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CRH08_RS02055	COG1713	HD superfamily hydrolase involved in NAD metabolism
CRH08_RS02070	COG0799	negative regulation of ribosome biogenesis
CRH08_RS02080	COG2226	methyltransferase
CRH08_RS02095	COG0789	Transcriptional regulator
CRH08_RS02105	COG0242	peptide deformylase activity
CRH08_RS02115	COG1640	4-alpha-glucanotransferase
CRH08_RS02120	COG0058	SHG alpha-glucan phosphorylase activity
CRH08_RS02135	COG1263	PTS System
CRH08_RS02135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRH08_RS02135	COG2190	(PTS) system
CRH08_RS02150	COG0217	transcriptional regulatory protein
CRH08_RS02160	COG4720	Psort location CytoplasmicMembrane, score
CRH08_RS02170	COG1054	Belongs to the UPF0176 family
CRH08_RS02180	COG1122	ATPase activity
CRH08_RS02195	COG0357	Ribosomal RNA small subunit methyltransferase G
CRH08_RS02200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CRH08_RS02205	COG3331	DNA recombination
CRH08_RS02210	COG4474	Belongs to the UPF0398 family
CRH08_RS02215	COG3599	regulation of cell shape
CRH08_RS02225	COG0116	Belongs to the methyltransferase superfamily
CRH08_RS02235	COG1854	S-ribosylhomocysteine lyase activity
CRH08_RS02240	COG1418	mRNA catabolic process
CRH08_RS02250	COG1758	RNA polymerase activity
CRH08_RS02260	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CRH08_RS02265	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CRH08_RS02270	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CRH08_RS02270	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CRH08_RS02275	COG0631	protein serine/threonine phosphatase activity
CRH08_RS02280	COG0515	serine threonine protein kinase
CRH08_RS02280	COG2815	serine threonine protein kinase
CRH08_RS02305	COG1098	S1 RNA binding domain
CRH08_RS02315	COG4974	Belongs to the 'phage' integrase family
CRH08_RS02475	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CRH08_RS02480	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CRH08_RS02485	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CRH08_RS02500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CRH08_RS02505	COG3022	response to hydroperoxide
CRH08_RS02515	COG3944	biosynthesis protein
CRH08_RS02525	COG4464	protein tyrosine phosphatase activity
CRH08_RS02540	COG0438	transferase activity, transferring glycosyl groups
CRH08_RS02555	COG1216	Glycosyl transferase, family 2
CRH08_RS02555	COG1442	glycosyl transferase family 8
CRH08_RS02560	COG1442	glycosyl transferase family 8
CRH08_RS02560	COG1216	Glycosyl transferase, family 2
CRH08_RS02595	COG2089	acid synthase
CRH08_RS02610	COG2755	lipolytic protein G-D-S-L family
CRH08_RS02610	COG1083	cytidylyl-transferase
CRH08_RS02675	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CRH08_RS02680	COG0077	Prephenate dehydratase
CRH08_RS02690	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CRH08_RS02700	COG0562	UDP-galactopyranose mutase
CRH08_RS02705	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CRH08_RS02720	COG0436	Aminotransferase
CRH08_RS02730	COG0017	Asparaginyl-tRNA synthetase
CRH08_RS02750	COG0534	Mate efflux family protein
CRH08_RS02755	COG0251	oxidation-reduction process
CRH08_RS02760	COG1660	Displays ATPase and GTPase activities
CRH08_RS02765	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CRH08_RS02770	COG1481	regulation of sporulation
CRH08_RS02785	COG0454	-acetyltransferase
CRH08_RS02790	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CRH08_RS02795	COG0549	Belongs to the carbamate kinase family
CRH08_RS02800	COG1288	antiporter activity
CRH08_RS02805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CRH08_RS02810	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CRH08_RS02810	COG3064	Membrane
CRH08_RS02810	COG3583	domain protein
CRH08_RS02815	COG1438	arginine binding
CRH08_RS02820	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CRH08_RS02825	COG0363	glucosamine-6-phosphate deaminase activity
CRH08_RS02855	COG1696	Membrane protein involved in D-alanine export
CRH08_RS02860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CRH08_RS02865	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CRH08_RS02875	COG0435	Glutathione S-transferase
CRH08_RS02880	COG1187	pseudouridine synthase activity
CRH08_RS02885	COG0386	Belongs to the glutathione peroxidase family
CRH08_RS02890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRH08_RS02895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRH08_RS02900	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CRH08_RS02905	COG1120	ATPase activity
CRH08_RS02910	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CRH08_RS02915	COG0204	Acyl-transferase
CRH08_RS02920	COG1555	photosystem II stabilization
CRH08_RS02920	COG1596	polysaccharide export
CRH08_RS02925	COG2333	competence protein COMEC
CRH08_RS02925	COG0658	competence protein
CRH08_RS02930	COG0517	IMP dehydrogenase activity
CRH08_RS02945	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CRH08_RS02950	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CRH08_RS02955	COG0470	DNA polymerase III
CRH08_RS02960	COG4467	Involved in initiation control of chromosome replication
CRH08_RS02970	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CRH08_RS02980	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CRH08_RS02985	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CRH08_RS02990	COG1393	Belongs to the ArsC family
CRH08_RS03005	COG0708	Exodeoxyribonuclease III
CRH08_RS03015	COG0531	amino acid
CRH08_RS03045	COG1061	Type III restriction enzyme res subunit
CRH08_RS03075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CRH08_RS03080	COG4684	Psort location CytoplasmicMembrane, score
CRH08_RS03085	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CRH08_RS03095	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CRH08_RS03135	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CRH08_RS03140	COG1349	DNA-binding transcription factor activity
CRH08_RS03150	COG1447	Phosphotransferase system cellobiose-specific component IIA
CRH08_RS03155	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CRH08_RS03160	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CRH08_RS03165	COG1882	Formate acetyltransferase
CRH08_RS03185	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CRH08_RS03190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CRH08_RS03210	COG1739	Uncharacterized protein family UPF0029
CRH08_RS03215	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CRH08_RS03300	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CRH08_RS03310	COG3557	Belongs to the UPF0374 family
CRH08_RS03320	COG2188	Transcriptional regulator
CRH08_RS03325	COG2188	Transcriptional regulator
CRH08_RS03335	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRH08_RS03345	COG3716	PTS system mannose fructose sorbose family IID component
CRH08_RS03355	COG2017	converts alpha-aldose to the beta-anomer
CRH08_RS03370	COG0346	lactoylglutathione lyase activity
CRH08_RS03405	COG0494	nUDIX hydrolase
CRH08_RS03420	COG1217	gtp-binding protein TYPA
CRH08_RS03435	COG0681	Belongs to the peptidase S26 family
CRH08_RS03470	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CRH08_RS03485	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CRH08_RS03490	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CRH08_RS03495	COG1799	cell septum assembly
CRH08_RS03510	COG3599	regulation of cell shape
CRH08_RS03535	COG0406	alpha-ribazole phosphatase activity
CRH08_RS03535	COG0494	nUDIX hydrolase
CRH08_RS03540	COG0542	response to heat
CRH08_RS03545	COG4703	Protein of unknown function (DUF1797)
CRH08_RS03550	COG0765	amino acid transport
CRH08_RS03560	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CRH08_RS03600	COG0789	Transcriptional regulator
CRH08_RS03615	COG0826	peptidase U32
CRH08_RS03630	COG4443	Transcriptional Coactivator p15 (PC4)
CRH08_RS03635	COG1268	BioY protein
CRH08_RS03645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CRH08_RS03655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CRH08_RS03660	COG1136	(ABC) transporter
CRH08_RS03665	COG0577	efflux transmembrane transporter activity
CRH08_RS03685	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CRH08_RS03695	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CRH08_RS03705	COG3859	Proton-coupled thiamine transporter YuaJ
CRH08_RS03725	COG0772	Belongs to the SEDS family
CRH08_RS03730	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CRH08_RS03745	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CRH08_RS03750	COG0149	triose-phosphate isomerase activity
CRH08_RS03760	COG1078	dGTPase activity
CRH08_RS03795	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CRH08_RS03805	COG2884	Cell division ATP-binding protein ftsE
CRH08_RS03810	COG2177	Part of the ABC transporter FtsEX involved in
CRH08_RS03835	COG1132	(ABC) transporter
CRH08_RS03840	COG1132	(ABC) transporter
CRH08_RS03845	COG1011	Hydrolase
CRH08_RS03865	COG1737	Transcriptional regulator
CRH08_RS03875	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CRH08_RS03880	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CRH08_RS03885	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CRH08_RS03890	COG0237	dephospho-CoA kinase activity
CRH08_RS03895	COG2814	Major facilitator Superfamily
CRH08_RS03900	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CRH08_RS03910	COG0017	Asparaginyl-tRNA synthetase
CRH08_RS03915	COG0557	exoribonuclease II activity
CRH08_RS03920	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CRH08_RS03925	COG1063	alcohol dehydrogenase
CRH08_RS03940	COG2217	Heavy metal translocating P-type atpase
CRH08_RS03945	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CRH08_RS03955	COG1136	(ABC) transporter
CRH08_RS03975	COG3547	Transposase (IS116 IS110 IS902 family)
CRH08_RS03995	COG0626	cystathionine gamma-synthase activity
CRH08_RS04000	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CRH08_RS04005	COG2207	Transcriptional regulator
CRH08_RS04015	COG1653	transport
CRH08_RS04020	COG1175	transmembrane transport
CRH08_RS04025	COG0395	ABC-type sugar transport system, permease component
CRH08_RS04035	COG0366	Alpha amylase catalytic
CRH08_RS04040	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CRH08_RS04055	COG0683	leucine binding
CRH08_RS04090	COG1466	dna polymerase III delta subunit
CRH08_RS04095	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CRH08_RS04100	COG0737	Belongs to the 5'-nucleotidase family
CRH08_RS04375	COG0038	chloride channel
CRH08_RS04380	COG0287	Prephenate dehydrogenase
CRH08_RS04380	COG1605	Chorismate mutase
CRH08_RS04390	COG0716	FMN binding
CRH08_RS04395	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CRH08_RS04415	COG1702	phosphate starvation-inducible protein PhoH
CRH08_RS04420	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CRH08_RS04425	COG2807	transmembrane transport
CRH08_RS04435	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CRH08_RS04440	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CRH08_RS04450	COG1234	tRNA 3'-trailer cleavage
CRH08_RS04455	COG0300	oxidoreductase activity
CRH08_RS04465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CRH08_RS04470	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CRH08_RS04470	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CRH08_RS04480	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CRH08_RS04495	COG2384	SAM-dependent methyltransferase
CRH08_RS04500	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CRH08_RS04510	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CRH08_RS04525	COG1088	dTDP-glucose 4,6-dehydratase activity
CRH08_RS04530	COG1091	dTDP-4-dehydrorhamnose reductase activity
CRH08_RS04560	COG1442	glycosyl transferase family 8
CRH08_RS04560	COG1216	Glycosyl transferase, family 2
CRH08_RS04590	COG1442	glycosyl transferase family 8
CRH08_RS04595	COG1216	Glycosyl transferase, family 2
CRH08_RS04595	COG1442	glycosyl transferase family 8
CRH08_RS04610	COG1216	Glycosyl transferase, family 2
CRH08_RS04640	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CRH08_RS04650	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CRH08_RS04665	COG1368	sulfuric ester hydrolase activity
CRH08_RS04670	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CRH08_RS04675	COG0710	3-dehydroquinate dehydratase activity
CRH08_RS04680	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CRH08_RS04685	COG0287	Prephenate dehydrogenase
CRH08_RS04690	COG3679	Belongs to the UPF0342 family
CRH08_RS04815	COG1164	Oligoendopeptidase f
CRH08_RS04830	COG0210	DNA helicase
CRH08_RS04840	COG1011	Hydrolase
CRH08_RS04870	COG1131	(ABC) transporter
CRH08_RS04900	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CRH08_RS04905	COG1074	ATP-dependent DNA helicase activity
CRH08_RS04915	COG0187	DNA topoisomerase II activity
CRH08_RS04920	COG2184	nucleotidyltransferase activity
CRH08_RS04935	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CRH08_RS04945	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CRH08_RS04970	COG0539	negative regulation of cytoplasmic translation
CRH08_RS04995	COG1104	cysteine desulfurase activity
CRH08_RS05000	COG0301	tRNA thio-modification
CRH08_RS05005	COG1114	Component of the transport system for branched-chain amino acids
CRH08_RS05015	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CRH08_RS05020	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CRH08_RS05040	COG0564	pseudouridine synthase activity
CRH08_RS05045	COG2824	Alkylphosphonate utilization operon protein PhnA
CRH08_RS05055	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CRH08_RS05060	COG0540	Belongs to the ATCase OTCase family
CRH08_RS05065	COG0505	Belongs to the CarA family
CRH08_RS05075	COG2136	Putative SAM-dependent methyltransferase
CRH08_RS05075	COG2521	methyltransferase
CRH08_RS05080	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CRH08_RS05090	COG0228	four-way junction DNA binding
CRH08_RS05105	COG1132	(ABC) transporter
CRH08_RS05110	COG0726	polysaccharide deacetylase
CRH08_RS05120	COG0083	homoserine kinase activity
CRH08_RS05130	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CRH08_RS05135	COG3842	ATPase activity
CRH08_RS05140	COG1176	ABC-type spermidine putrescine transport system, permease component I
CRH08_RS05145	COG1177	transmembrane transport
CRH08_RS05155	COG0038	chloride channel
CRH08_RS05170	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CRH08_RS05175	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CRH08_RS05185	COG0534	Mate efflux family protein
CRH08_RS05190	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CRH08_RS05195	COG0336	Belongs to the RNA methyltransferase TrmD family
CRH08_RS05200	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CRH08_RS05205	COG1349	DNA-binding transcription factor activity
CRH08_RS05210	COG1105	Belongs to the carbohydrate kinase PfkB family
CRH08_RS05215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRH08_RS05215	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CRH08_RS05215	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CRH08_RS05225	COG1307	EDD domain protein, DegV family
CRH08_RS05230	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CRH08_RS05235	COG0617	tRNA 3'-terminal CCA addition
CRH08_RS05240	COG0488	(ABC) transporter
CRH08_RS05250	COG1940	carbohydrate kinase activity
CRH08_RS05265	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CRH08_RS05270	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CRH08_RS05280	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CRH08_RS05295	COG0481	GTPase activity
CRH08_RS05320	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CRH08_RS05325	COG2890	protein-(glutamine-N5) methyltransferase activity
CRH08_RS05330	COG0009	L-threonylcarbamoyladenylate synthase
CRH08_RS05340	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CRH08_RS05350	COG0741	lytic transglycosylase activity
CRH08_RS05355	COG4221	oxidoreductase activity
CRH08_RS05380	COG1401	restriction endodeoxyribonuclease activity
CRH08_RS05385	COG4268	DNA restriction-modification system
CRH08_RS05395	COG2188	Transcriptional regulator
CRH08_RS05400	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CRH08_RS05405	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CRH08_RS05420	COG1660	Displays ATPase and GTPase activities
CRH08_RS05425	COG4974	Belongs to the 'phage' integrase family
CRH08_RS05440	COG0745	RESPONSE REGULATOR receiver
CRH08_RS05460	COG1136	(ABC) transporter
CRH08_RS05490	COG2382	esterase
CRH08_RS05500	COG3708	Transcriptional regulator
CRH08_RS05500	COG2207	Transcriptional regulator
CRH08_RS05505	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CRH08_RS05510	COG0647	UMP catabolic process
CRH08_RS05550	COG0395	ABC-type sugar transport system, permease component
CRH08_RS05555	COG1175	transmembrane transport
CRH08_RS05575	COG1070	Carbohydrate kinase
CRH08_RS05590	COG3843	relaxase mobilization nuclease domain protein
CRH08_RS05610	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CRH08_RS05630	COG0827	DNA restriction-modification system
CRH08_RS05645	COG0270	DNA (cytosine-5-)-methyltransferase activity
CRH08_RS05665	COG1705	Flagellar rod assembly protein muramidase FlgJ
CRH08_RS05665	COG3942	CHAP domain
CRH08_RS05715	COG4974	Belongs to the 'phage' integrase family
CRH08_RS05725	COG1396	sequence-specific DNA binding
CRH08_RS05745	COG1447	Phosphotransferase system cellobiose-specific component IIA
CRH08_RS05755	COG1105	Belongs to the carbohydrate kinase PfkB family
CRH08_RS05765	COG0698	ribose 5-phosphate isomerase
CRH08_RS05770	COG1940	carbohydrate kinase activity
CRH08_RS05785	COG3843	relaxase mobilization nuclease domain protein
CRH08_RS05805	COG0210	DNA helicase
CRH08_RS05830	COG0542	response to heat
CRH08_RS05835	COG1396	sequence-specific DNA binding
CRH08_RS05890	COG4443	Transcriptional Coactivator p15 (PC4)
CRH08_RS05895	COG1475	DNA binding
CRH08_RS06030	COG0270	DNA (cytosine-5-)-methyltransferase activity
CRH08_RS06045	COG0222	ribosome binding
CRH08_RS06050	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CRH08_RS06055	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CRH08_RS06060	COG0758	DNA mediated transformation
CRH08_RS06065	COG0110	maltose O-acetyltransferase activity
CRH08_RS06070	COG1937	Protein conserved in bacteria
CRH08_RS06080	COG0446	pyridine nucleotide-disulphide oxidoreductase
CRH08_RS06090	COG1272	protein, Hemolysin III
CRH08_RS06100	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CRH08_RS06105	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CRH08_RS06115	COG0424	maF-like protein
CRH08_RS06120	COG0737	Belongs to the 5'-nucleotidase family
CRH08_RS06130	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CRH08_RS06135	COG0463	Glycosyl transferase, family 2
CRH08_RS06145	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CRH08_RS06150	COG0284	orotidine-5'-phosphate decarboxylase activity
CRH08_RS06155	COG0167	dihydroorotate dehydrogenase activity
CRH08_RS06165	COG0583	DNA-binding transcription factor activity
CRH08_RS06180	COG0297	glycogen (starch) synthase activity
CRH08_RS06190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRH08_RS06195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRH08_RS06240	COG1126	abc transporter atp-binding protein
CRH08_RS06250	COG0488	(ABC) transporter
CRH08_RS06255	COG2873	o-acetylhomoserine
CRH08_RS06280	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CRH08_RS06280	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CRH08_RS06290	COG3711	transcriptional antiterminator
CRH08_RS06295	COG3684	Belongs to the aldolase LacD family
CRH08_RS06300	COG1105	Belongs to the carbohydrate kinase PfkB family
CRH08_RS06305	COG0698	ribose 5-phosphate isomerase
CRH08_RS06310	COG0698	ribose 5-phosphate isomerase
CRH08_RS06320	COG1349	DNA-binding transcription factor activity
CRH08_RS06350	COG1396	sequence-specific DNA binding
CRH08_RS06355	COG1194	a g-specific adenine glycosylase
CRH08_RS06365	COG1132	(ABC) transporter
CRH08_RS06370	COG1132	(ABC) transporter
CRH08_RS06375	COG0280	phosphate acetyltransferase
CRH08_RS06380	COG0564	pseudouridine synthase activity
CRH08_RS06385	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CRH08_RS06390	COG2357	RelA SpoT domain protein
CRH08_RS06395	COG4116	CYTH
CRH08_RS06405	COG1104	cysteine desulfurase activity
CRH08_RS06420	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CRH08_RS06425	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CRH08_RS06435	COG3764	Sortase (surface protein transpeptidase)
CRH08_RS06440	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CRH08_RS06445	COG0039	L-malate dehydrogenase activity
CRH08_RS06450	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CRH08_RS06460	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CRH08_RS06465	COG1079	Belongs to the binding-protein-dependent transport system permease family
CRH08_RS06470	COG4603	Belongs to the binding-protein-dependent transport system permease family
CRH08_RS06475	COG3845	ABC transporter
CRH08_RS06480	COG1744	ABC transporter substrate-binding protein PnrA-like
CRH08_RS06495	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CRH08_RS06500	COG2813	Specifically methylates the guanine in position
CRH08_RS06505	COG1072	(Pantothenic acid kinase))
CRH08_RS06525	COG5002	protein histidine kinase activity
CRH08_RS06530	COG0745	RESPONSE REGULATOR receiver
CRH08_RS06750	COG0556	nucleotide-excision repair
CRH08_RS06785	COG3561	AntA/AntB antirepressor
CRH08_RS06835	COG0704	Plays a role in the regulation of phosphate uptake
CRH08_RS06840	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CRH08_RS06845	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CRH08_RS06850	COG0581	inorganic phosphate transmembrane transporter activity
CRH08_RS06855	COG0573	inorganic phosphate transmembrane transporter activity
CRH08_RS06865	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CRH08_RS06865	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CRH08_RS06870	COG0483	inositol monophosphate 1-phosphatase activity
CRH08_RS06875	COG4476	Belongs to the UPF0223 family
CRH08_RS06880	COG1393	Belongs to the ArsC family
CRH08_RS06885	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CRH08_RS06890	COG0196	riboflavin kinase activity
CRH08_RS06895	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CRH08_RS06935	COG0561	phosphatase activity
CRH08_RS06940	COG2195	Cleaves the N-terminal amino acid of tripeptides
CRH08_RS06955	COG1695	Transcriptional regulator
CRH08_RS06975	COG3759	membrane
CRH08_RS06980	COG1846	Transcriptional regulator
CRH08_RS06995	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CRH08_RS07000	COG2610	gluconate transmembrane transporter activity
CRH08_RS07020	COG0302	gtp cyclohydrolase
CRH08_RS07025	COG1051	belongs to the nudix hydrolase family
CRH08_RS07050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CRH08_RS07050	COG0072	phenylalanine-tRNA ligase activity
CRH08_RS07080	COG1028	Short-chain dehydrogenase reductase Sdr
CRH08_RS07085	COG1312	Catalyzes the dehydration of D-mannonate
CRH08_RS07095	COG0800	Aldolase
CRH08_RS07105	COG3250	beta-galactosidase activity
CRH08_RS07115	COG2211	Major facilitator Superfamily
CRH08_RS07130	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CRH08_RS07140	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CRH08_RS07145	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CRH08_RS07150	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CRH08_RS07155	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CRH08_RS07160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CRH08_RS07165	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CRH08_RS07170	COG0356	it plays a direct role in the translocation of protons across the membrane
CRH08_RS07180	COG1597	lipid kinase activity
CRH08_RS07190	COG0701	Predicted permease
CRH08_RS07195	COG3689	TIGRFAM TIGR03943 family protein
CRH08_RS07200	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CRH08_RS07215	COG0552	protein localization to endoplasmic reticulum
CRH08_RS07220	COG0561	phosphatase activity
CRH08_RS07225	COG0561	phosphatase activity
CRH08_RS07230	COG1196	nuclear chromosome segregation
CRH08_RS07270	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRH08_RS07275	COG0538	isocitrate dehydrogenase activity
CRH08_RS07280	COG0372	Belongs to the citrate synthase family
CRH08_RS07285	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CRH08_RS07290	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CRH08_RS07295	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CRH08_RS07300	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CRH08_RS07305	COG1609	Transcriptional regulator
CRH08_RS07320	COG5492	domain, Protein
CRH08_RS07330	COG3716	PTS system mannose fructose sorbose family IID component
CRH08_RS07340	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRH08_RS07345	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
CRH08_RS07370	COG1028	Short-chain dehydrogenase reductase Sdr
CRH08_RS07405	COG1476	TRANSCRIPTIONal
CRH08_RS07425	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CRH08_RS07435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CRH08_RS07440	COG4122	O-methyltransferase activity
CRH08_RS07465	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CRH08_RS07465	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CRH08_RS07480	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CRH08_RS07485	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CRH08_RS07490	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CRH08_RS07495	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CRH08_RS07505	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CRH08_RS07505	COG1116	anion transmembrane transporter activity
CRH08_RS07510	COG4120	Belongs to the binding-protein-dependent transport system permease family
CRH08_RS07530	COG3684	Belongs to the aldolase LacD family
CRH08_RS07545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRH08_RS07550	COG1126	abc transporter atp-binding protein
CRH08_RS07555	COG0765	amino acid transport
CRH08_RS07560	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CRH08_RS07575	COG0657	acetylesterase activity
CRH08_RS07575	COG2755	lipolytic protein G-D-S-L family
CRH08_RS07580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CRH08_RS07600	COG0469	pyruvate kinase activity
CRH08_RS07605	COG0205	6-phosphofructokinase activity
CRH08_RS07615	COG2188	Transcriptional regulator
CRH08_RS07620	COG1131	(ABC) transporter
CRH08_RS07630	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CRH08_RS07665	COG2151	metal-sulfur cluster biosynthetic enzyme
CRH08_RS07670	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CRH08_RS07675	COG0358	DNA primase activity
CRH08_RS07680	COG1970	mechanosensitive ion channel activity
CRH08_RS07690	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CRH08_RS07695	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CRH08_RS07705	COG0647	UMP catabolic process
CRH08_RS07710	COG1051	belongs to the nudix hydrolase family
CRH08_RS07720	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CRH08_RS07730	COG0058	SHG alpha-glucan phosphorylase activity
CRH08_RS07735	COG0813	purine-nucleoside phosphorylase activity
CRH08_RS07740	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CRH08_RS07750	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CRH08_RS07755	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CRH08_RS07770	COG1518	maintenance of DNA repeat elements
CRH08_RS07780	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CRH08_RS07795	COG2268	Band 7 protein
CRH08_RS07800	COG1704	LemA family
CRH08_RS07810	COG1573	uracil-dna glycosylase
CRH08_RS07830	COG2226	methyltransferase
CRH08_RS07835	COG0488	(ABC) transporter
CRH08_RS07840	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CRH08_RS07855	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CRH08_RS07860	COG3442	glutamine amidotransferase
CRH08_RS07865	COG2226	methyltransferase
CRH08_RS07875	COG0488	(ABC) transporter
CRH08_RS07910	COG3842	ATPase activity
CRH08_RS07930	COG1263	PTS System
CRH08_RS07930	COG2190	(PTS) system
CRH08_RS07930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRH08_RS07935	COG3711	transcriptional antiterminator
CRH08_RS07940	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CRH08_RS07945	COG3527	Alpha-acetolactate decarboxylase
CRH08_RS07955	COG0628	permease
CRH08_RS07960	COG2706	6-phosphogluconolactonase activity
CRH08_RS07970	COG1011	Hydrolase
CRH08_RS08095	COG0560	Phosphoserine phosphatase
CRH08_RS08100	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CRH08_RS08105	COG0187	DNA topoisomerase II activity
CRH08_RS08110	COG0693	protein deglycase activity
CRH08_RS08115	COG0772	Belongs to the SEDS family
CRH08_RS08125	COG4479	Belongs to the UPF0346 family
CRH08_RS08140	COG2996	Protein conserved in bacteria
CRH08_RS08145	COG0233	cytoplasmic translational termination
CRH08_RS08150	COG0528	UMP kinase activity
CRH08_RS08155	COG2244	polysaccharide biosynthetic process
CRH08_RS08165	COG0625	glutathione transferase activity
CRH08_RS08190	COG0346	lactoylglutathione lyase activity
CRH08_RS08195	COG1674	ftsk spoiiie
CRH08_RS08195	COG0697	spore germination
CRH08_RS08200	COG1621	beta-fructofuranosidase activity
CRH08_RS08205	COG1653	transport
CRH08_RS08215	COG0395	ABC-type sugar transport system, permease component
CRH08_RS08220	COG4209	transmembrane transport
CRH08_RS08225	COG1609	Transcriptional regulator
CRH08_RS08245	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CRH08_RS08260	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CRH08_RS08270	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CRH08_RS08295	COG1181	Belongs to the D-alanine--D-alanine ligase family
CRH08_RS08300	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CRH08_RS08305	COG0768	penicillin binding
CRH08_RS08310	COG0488	(ABC) transporter
CRH08_RS08325	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CRH08_RS08335	COG0745	RESPONSE REGULATOR receiver
CRH08_RS08345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRH08_RS08350	COG0765	amino acid transport
CRH08_RS08355	COG0765	amino acid transport
CRH08_RS08360	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CRH08_RS08375	COG0438	transferase activity, transferring glycosyl groups
CRH08_RS08390	COG1609	Transcriptional regulator
CRH08_RS08405	COG0343	queuine tRNA-ribosyltransferase activity
CRH08_RS08415	COG1832	CoA-binding protein
CRH08_RS08425	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CRH08_RS08425	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CRH08_RS08435	COG3547	Transposase (IS116 IS110 IS902 family)
CRH08_RS08445	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CRH08_RS08450	COG2827	Endonuclease containing a URI domain
CRH08_RS08470	COG0640	Transcriptional regulator
CRH08_RS08475	COG0513	Belongs to the DEAD box helicase family
CRH08_RS08485	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CRH08_RS08530	COG0494	nUDIX hydrolase
CRH08_RS08535	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CRH08_RS08545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CRH08_RS08550	COG1028	Short-chain dehydrogenase reductase Sdr
CRH08_RS08575	COG0577	efflux transmembrane transporter activity
CRH08_RS08580	COG1136	(ABC) transporter
CRH08_RS08585	COG2205	protein histidine kinase activity
CRH08_RS08600	COG0436	Aminotransferase
CRH08_RS08610	COG1174	glycine betaine transport
CRH08_RS08615	COG1125	glycine betaine transport
CRH08_RS08615	COG0517	IMP dehydrogenase activity
CRH08_RS08635	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CRH08_RS08640	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CRH08_RS08645	COG1482	cell wall glycoprotein biosynthetic process
CRH08_RS08660	COG3091	SprT-like family
CRH08_RS08665	COG2183	response to ionizing radiation
CRH08_RS08685	COG0656	L-ascorbic acid biosynthetic process
CRH08_RS08690	COG4708	membrane
CRH08_RS08695	COG2246	polysaccharide biosynthetic process
CRH08_RS08705	COG0024	Methionine aminopeptidase
CRH08_RS08715	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CRH08_RS08720	COG2249	NAD(P)H dehydrogenase (quinone) activity
CRH08_RS08725	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CRH08_RS08735	COG2131	deaminase
CRH08_RS08755	COG1363	Peptidase, m42
CRH08_RS08770	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CRH08_RS08775	COG1956	GAF domain-containing protein
CRH08_RS08795	COG0673	inositol 2-dehydrogenase activity
CRH08_RS08800	COG0513	Belongs to the DEAD box helicase family
CRH08_RS08805	COG0726	polysaccharide deacetylase
CRH08_RS08820	COG0183	Belongs to the thiolase family
CRH08_RS08825	COG3425	synthase
CRH08_RS08850	COG0776	regulation of translation
CRH08_RS08860	COG2755	lipolytic protein G-D-S-L family
CRH08_RS08865	COG1307	EDD domain protein, DegV family
CRH08_RS08870	COG0497	DNA recombination
CRH08_RS08875	COG1438	arginine binding
CRH08_RS08880	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CRH08_RS08890	COG1722	exodeoxyribonuclease VII activity
CRH08_RS08895	COG1570	exodeoxyribonuclease VII activity
CRH08_RS08900	COG2321	neutral zinc metallopeptidase
CRH08_RS08905	COG1755	Isoprenylcysteine carboxyl methyltransferase
CRH08_RS08910	COG5002	protein histidine kinase activity
CRH08_RS08915	COG0745	RESPONSE REGULATOR receiver
CRH08_RS08935	COG1227	inorganic diphosphatase activity
CRH08_RS08945	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CRH08_RS08950	COG1253	flavin adenine dinucleotide binding
CRH08_RS08955	COG1119	ATPase activity
CRH08_RS08960	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CRH08_RS08970	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CRH08_RS08975	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CRH08_RS08990	COG4470	Protein conserved in bacteria
CRH08_RS09000	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CRH08_RS09005	COG0742	ribosomal rna small subunit methyltransferase
CRH08_RS09015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CRH08_RS09020	COG4483	Protein conserved in bacteria
CRH08_RS09025	COG2197	response regulator
CRH08_RS09030	COG4585	Histidine kinase
CRH08_RS09030	COG2203	Gaf domain
CRH08_RS09035	COG0842	Transport permease protein
CRH08_RS09040	COG1131	(ABC) transporter
CRH08_RS09060	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CRH08_RS09070	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CRH08_RS09070	COG2755	lipolytic protein G-D-S-L family
CRH08_RS09075	COG0671	phosphoesterase, PA-phosphatase related
CRH08_RS09080	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CRH08_RS09095	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CRH08_RS09100	COG1187	pseudouridine synthase activity
CRH08_RS09105	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CRH08_RS09110	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CRH08_RS09115	COG0582	viral genome integration into host DNA
CRH08_RS09135	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CRH08_RS09140	COG3763	UPF0154 protein
CRH08_RS09150	COG3579	cysteine-type endopeptidase activity
CRH08_RS09165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CRH08_RS09170	COG1254	Belongs to the acylphosphatase family
CRH08_RS09175	COG0706	membrane insertase activity
CRH08_RS09180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CRH08_RS09185	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CRH08_RS09195	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CRH08_RS09205	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CRH08_RS09220	COG1160	GTP binding
CRH08_RS09230	COG1484	DNA-dependent DNA replication
CRH08_RS09240	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CRH08_RS09245	COG0628	permease
CRH08_RS09250	COG0745	RESPONSE REGULATOR receiver
CRH08_RS09255	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CRH08_RS09265	COG0492	ferredoxin-NADP+ reductase activity
CRH08_RS09275	COG0513	Belongs to the DEAD box helicase family
CRH08_RS09295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CRH08_RS09300	COG0768	penicillin binding
CRH08_RS09310	COG0275	rRNA processing
CRH08_RS09365	COG4939	FMN-binding domain protein
CRH08_RS09370	COG0142	geranyltranstransferase activity
CRH08_RS09375	COG1252	NADH dehydrogenase
CRH08_RS09390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CRH08_RS09395	COG0569	domain protein
CRH08_RS09400	COG0534	Mate efflux family protein
CRH08_RS09410	COG4224	UPF0291 protein
CRH08_RS09415	COG0751	glycine-tRNA ligase activity
CRH08_RS09440	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CRH08_RS09445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CRH08_RS09450	COG1464	Belongs to the NlpA lipoprotein family
CRH08_RS09455	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CRH08_RS09460	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CRH08_RS09470	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CRH08_RS09480	COG0561	phosphatase activity
CRH08_RS09490	COG3715	PTS system
CRH08_RS09495	COG3716	PTS system mannose fructose sorbose family IID component
CRH08_RS09520	COG3177	Filamentation induced by cAMP protein fic
CRH08_RS09530	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CRH08_RS09565	COG0825	malonyl-CoA metabolic process
CRH08_RS09575	COG0439	Biotin carboxylase
CRH08_RS09600	COG1028	Short-chain dehydrogenase reductase Sdr
CRH08_RS09605	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CRH08_RS09610	COG2070	2-Nitropropane dioxygenase
CRH08_RS09620	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CRH08_RS09630	COG1024	Enoyl-CoA hydratase
CRH08_RS09635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CRH08_RS09640	COG0527	aspartate kinase activity
CRH08_RS09645	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CRH08_RS09650	COG0736	holo-[acyl-carrier-protein] synthase activity
CRH08_RS09655	COG0653	protein targeting
CRH08_RS09665	COG1940	carbohydrate kinase activity
CRH08_RS09670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRH08_RS09670	COG1263	PTS System
CRH08_RS09670	COG2190	(PTS) system
CRH08_RS09675	COG1621	beta-fructofuranosidase activity
CRH08_RS09680	COG1609	Transcriptional regulator
CRH08_RS09685	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CRH08_RS09700	COG0006	proline dipeptidase activity
CRH08_RS09705	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CRH08_RS09720	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CRH08_RS09725	COG0629	single-stranded DNA binding
CRH08_RS09735	COG0095	Lipoate-protein ligase
CRH08_RS09740	COG2723	6-phospho-beta-galactosidase activity
CRH08_RS09755	COG2723	6-phospho-beta-galactosidase activity
CRH08_RS09760	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CRH08_RS09770	COG1447	Phosphotransferase system cellobiose-specific component IIA
CRH08_RS09775	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRH08_RS09775	COG3711	transcriptional antiterminator
CRH08_RS09790	COG4095	Psort location CytoplasmicMembrane, score
CRH08_RS09795	COG2723	6-phospho-beta-galactosidase activity
CRH08_RS09800	COG0346	lactoylglutathione lyase activity
CRH08_RS09805	COG2723	6-phospho-beta-galactosidase activity
CRH08_RS09810	COG1917	Cupin 2, conserved barrel domain protein
CRH08_RS09810	COG2207	Transcriptional regulator
CRH08_RS09820	COG2190	(PTS) system
CRH08_RS09820	COG1263	PTS System
CRH08_RS09820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRH08_RS09825	COG3711	transcriptional antiterminator
CRH08_RS09840	COG0508	dehydrogenase complex catalyzes the overall conversion of
CRH08_RS09845	COG0508	dehydrogenase complex catalyzes the overall conversion of
CRH08_RS09845	COG0022	dehydrogenase e1 component
CRH08_RS09850	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CRH08_RS09855	COG2860	membrane
CRH08_RS09870	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CRH08_RS09875	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CRH08_RS09885	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CRH08_RS09890	COG0195	Participates in both transcription termination and antitermination
CRH08_RS09900	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CRH08_RS09910	COG4473	ABC transporter
CRH08_RS09915	COG1131	(ABC) transporter
CRH08_RS09920	COG0537	adenosine 5'-monophosphoramidase activity
CRH08_RS09930	COG1316	TRANSCRIPTIONal
CRH08_RS09940	COG0802	atpase or kinase
CRH08_RS09960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRH08_RS09965	COG0601	transmembrane transport
CRH08_RS09970	COG4608	Belongs to the ABC transporter superfamily
CRH08_RS09980	COG0747	negative chemotaxis
CRH08_RS09985	COG1686	Belongs to the peptidase S11 family
CRH08_RS10000	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CRH08_RS10005	COG0719	Fe-S assembly protein
CRH08_RS10015	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CRH08_RS10020	COG4862	establishment of competence for transformation
CRH08_RS10025	COG1968	undecaprenyl-diphosphatase activity
CRH08_RS10030	COG0765	amino acid transport
CRH08_RS10035	COG1126	abc transporter atp-binding protein
CRH08_RS10050	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CRH08_RS10055	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CRH08_RS10060	COG0440	acetolactate synthase activity
CRH08_RS10065	COG0028	Belongs to the TPP enzyme family
CRH08_RS10080	COG0129	dihydroxy-acid dehydratase activity
CRH08_RS10090	COG2151	metal-sulfur cluster biosynthetic enzyme
CRH08_RS10145	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CRH08_RS10165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CRH08_RS10180	COG3842	ATPase activity
CRH08_RS10190	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CRH08_RS10210	COG1045	serine acetyltransferase
CRH08_RS10215	COG1185	polyribonucleotide nucleotidyltransferase activity
CRH08_RS10225	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CRH08_RS10230	COG1131	(ABC) transporter
CRH08_RS10275	COG1187	pseudouridine synthase activity
CRH08_RS10295	COG0242	peptide deformylase activity
CRH08_RS10305	COG0066	3-isopropylmalate dehydratase activity
CRH08_RS10325	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CRH08_RS10335	COG2188	Transcriptional regulator
CRH08_RS10340	COG1447	Phosphotransferase system cellobiose-specific component IIA
CRH08_RS10355	COG2309	aminopeptidase activity
CRH08_RS10375	COG2176	DNA-directed DNA polymerase activity
CRH08_RS10380	COG2376	Dihydroxyacetone kinase
CRH08_RS10390	COG2376	Dihydroxyacetone kinase
CRH08_RS10395	COG1461	Dihydroxyacetone kinase
CRH08_RS10400	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CRH08_RS10405	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CRH08_RS10410	COG0442	prolyl-tRNA aminoacylation
CRH08_RS10420	COG4589	Belongs to the CDS family
CRH08_RS10425	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CRH08_RS10430	COG1862	Preprotein translocase
CRH08_RS10440	COG1181	Belongs to the D-alanine--D-alanine ligase family
CRH08_RS10440	COG2918	glutathione biosynthetic process
CRH08_RS10450	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CRH08_RS10455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CRH08_RS10460	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CRH08_RS10465	COG0542	response to heat
CRH08_RS10470	COG4463	regulation of RNA biosynthetic process
CRH08_RS10480	COG1388	LysM domain
CRH08_RS10480	COG4932	domain protein
CRH08_RS10490	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CRH08_RS10525	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CRH08_RS10530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CRH08_RS10535	COG0492	ferredoxin-NADP+ reductase activity
CRH08_RS10540	COG0564	pseudouridine synthase activity
CRH08_RS10580	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CRH08_RS10600	COG1564	THIamine pyrophosphokinase
CRH08_RS10610	COG1162	GTPase activity
CRH08_RS10630	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CRH08_RS10635	COG1132	(ABC) transporter
CRH08_RS10665	COG4115	mRNA cleavage
CRH08_RS10690	COG0084	hydrolase, TatD family'
CRH08_RS10700	COG1847	R3H domain protein
CRH08_RS10710	COG0594	ribonuclease P activity
CRH08_RS10715	COG0165	Argininosuccinate lyase
CRH08_RS10720	COG0137	argininosuccinate synthase activity
CRH08_RS10730	COG1827	regulation of RNA biosynthetic process
CRH08_RS10785	COG0756	dUTP diphosphatase activity
CRH08_RS10790	COG1132	(ABC) transporter
CRH08_RS10795	COG1132	(ABC) transporter
CRH08_RS10805	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CRH08_RS10810	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CRH08_RS10815	COG0705	Rhomboid family
CRH08_RS10820	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CRH08_RS10825	COG1473	amidohydrolase
CRH08_RS10830	COG2171	N-acyltransferase activity
CRH08_RS10840	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CRH08_RS10865	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CRH08_RS10890	COG3623	hexulose-6-phosphate isomerase
CRH08_RS10915	COG1523	belongs to the glycosyl hydrolase 13 family
CRH08_RS10920	COG1609	Transcriptional regulator
CRH08_RS10925	COG1126	abc transporter atp-binding protein
CRH08_RS10930	COG0765	amino acid transport
CRH08_RS10935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRH08_RS10940	COG3942	CHAP domain
CRH08_RS10945	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CRH08_RS10955	COG1447	Phosphotransferase system cellobiose-specific component IIA
CRH08_RS10965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRH08_RS10965	COG3711	transcriptional antiterminator
CRH08_RS10975	COG2723	6-phospho-beta-galactosidase activity
CRH08_RS10980	COG1486	melibiose metabolic process
CRH08_RS10990	COG3590	peptidase
CRH08_RS10995	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CRH08_RS11000	COG1321	iron dependent repressor
CRH08_RS11000	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CRH08_RS11005	COG1121	(ABC) transporter
CRH08_RS11020	COG0803	Belongs to the bacterial solute-binding protein 9 family
CRH08_RS11040	COG1490	D-aminoacyl-tRNA deacylase activity
CRH08_RS11050	COG0737	Belongs to the 5'-nucleotidase family
CRH08_RS11075	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CRH08_RS11095	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CRH08_RS11125	COG0737	Belongs to the 5'-nucleotidase family
CRH08_RS11135	COG1328	CTP reductase activity
CRH08_RS11140	COG1126	abc transporter atp-binding protein
CRH08_RS11150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRH08_RS11155	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CRH08_RS11175	COG1438	arginine binding
CRH08_RS11180	COG0018	arginyl-trna synthetase
CRH08_RS11200	COG1640	4-alpha-glucanotransferase
CRH08_RS11205	COG2182	Extracellular solute-binding protein
CRH08_RS11210	COG1175	transmembrane transport
CRH08_RS11215	COG3833	ABC-type maltose transport systems, permease component
CRH08_RS11220	COG5521	maltodextrose utilization protein MalA
CRH08_RS11225	COG1609	Transcriptional regulator
CRH08_RS11230	COG1523	belongs to the glycosyl hydrolase 13 family
CRH08_RS11235	COG1780	Probably involved in ribonucleotide reductase function
CRH08_RS11240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CRH08_RS11245	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CRH08_RS11250	COG2153	protein acetylation
CRH08_RS11255	COG4989	oxidoreductase activity
CRH08_RS11260	COG1216	Glycosyl transferase, family 2
CRH08_RS11280	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CRH08_RS11290	COG0305	Participates in initiation and elongation during chromosome replication
CRH08_RS11295	COG0359	binds to the 23S rRNA
CRH08_RS11305	COG0445	tRNA wobble uridine modification
CRH08_RS11310	COG0494	nUDIX hydrolase
CRH08_RS11315	COG1733	regulation of RNA biosynthetic process
CRH08_RS11325	COG0482	sulfurtransferase activity
CRH08_RS11330	COG1760	l-serine dehydratase
CRH08_RS11335	COG1760	l-serine dehydratase
CRH08_RS11345	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CRH08_RS11350	COG1122	ATPase activity
CRH08_RS11355	COG1122	ATPase activity
CRH08_RS11360	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CRH08_RS11365	COG1426	Protein conserved in bacteria
CRH08_RS11370	COG0612	Peptidase, M16
CRH08_RS11375	COG0612	Peptidase, M16
CRH08_RS11455	COG0582	viral genome integration into host DNA
CRH08_RS11465	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CRH08_RS11475	COG0517	IMP dehydrogenase activity
CRH08_RS11475	COG0516	GMP reductase activity
CRH08_RS11485	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CRH08_RS11490	COG0488	(ABC) transporter
CRH08_RS11520	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CRH08_RS11525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CRH08_RS11530	COG1475	DNA binding