locus-tag	class	description
T15_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
T15_RS00010	COG0592	DNA-directed DNA polymerase activity
T15_RS00030	COG0012	GTP binding
T15_RS00035	COG0193	aminoacyl-tRNA hydrolase activity
T15_RS00040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
T15_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
T15_RS00065	COG0037	tRNA processing
T15_RS00075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
T15_RS00185	COG1792	Involved in formation and maintenance of cell shape
T15_RS00200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
T15_RS00205	COG0436	Aminotransferase
T15_RS00210	COG1381	Involved in DNA repair and RecF pathway recombination
T15_RS00215	COG0416	fatty acid biosynthetic process
T15_RS00220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
T15_RS00245	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
T15_RS00250	COG0138	bifunctional purine biosynthesis protein purh
T15_RS00255	COG0151	Belongs to the GarS family
T15_RS00260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
T15_RS00280	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
T15_RS00315	COG2255	four-way junction helicase activity
T15_RS00325	COG0546	phosphoglycolate phosphatase activity
T15_RS00340	COG2801	Transposase and inactivated derivatives
T15_RS00355	COG0285	dihydrofolate synthase activity
T15_RS00370	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
T15_RS00375	COG0632	four-way junction helicase activity
T15_RS00385	COG2818	Glycosylase
T15_RS00390	COG1396	sequence-specific DNA binding
T15_RS00410	COG1393	Belongs to the ArsC family
T15_RS00415	COG4472	Bacterial protein of unknown function (DUF965)
T15_RS00420	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
T15_RS00425	COG3906	Belongs to the UPF0473 family
T15_RS00435	COG0051	transcription antitermination factor activity, RNA binding
T15_RS00440	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
T15_RS00445	COG0088	Forms part of the polypeptide exit tunnel
T15_RS00450	COG0089	rRNA binding
T15_RS00455	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
T15_RS00460	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
T15_RS00465	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
T15_RS00470	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
T15_RS00475	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
T15_RS00480	COG0255	Belongs to the universal ribosomal protein uL29 family
T15_RS00485	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
T15_RS00490	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
T15_RS00495	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
T15_RS00500	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
T15_RS00505	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
T15_RS00510	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
T15_RS00520	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
T15_RS00525	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
T15_RS00530	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
T15_RS00535	COG1841	ribosomal large subunit assembly
T15_RS00545	COG0201	protein transport
T15_RS00550	COG0563	adenylate kinase activity
T15_RS00555	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
T15_RS00560	COG0257	Belongs to the bacterial ribosomal protein bL36 family
T15_RS00565	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
T15_RS00575	COG0202	RNA polymerase activity
T15_RS00690	COG1121	(ABC) transporter
T15_RS00695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
T15_RS00700	COG3443	Belongs to the bacterial solute-binding protein 9 family
T15_RS00700	COG0803	Belongs to the bacterial solute-binding protein 9 family
T15_RS00735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
T15_RS00740	COG0085	RNA polymerase activity
T15_RS00745	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
T15_RS00755	COG1619	proteins homologs of microcin C7 resistance protein MccF
T15_RS00760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
T15_RS00765	COG1459	type II secretion system
T15_RS00770	COG4537	Required for transformation and DNA binding
T15_RS00800	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
T15_RS00810	COG0285	dihydrofolate synthase activity
T15_RS00815	COG1363	Peptidase, m42
T15_RS00825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
T15_RS00835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
T15_RS00860	COG0459	protein refolding
T15_RS00870	COG0049	tRNA binding
T15_RS00875	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
T15_RS00890	COG0126	phosphoglycerate kinase activity
T15_RS00900	COG0789	Transcriptional regulator
T15_RS00905	COG0174	glutamine synthetase
T15_RS00920	COG1214	PFAM Peptidase M22, glycoprotease
T15_RS00930	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
T15_RS00935	COG2207	Transcriptional regulator
T15_RS00945	COG1175	transmembrane transport
T15_RS00950	COG0395	ABC-type sugar transport system, permease component
T15_RS00970	COG2855	membrane
T15_RS00980	COG1131	(ABC) transporter
T15_RS00985	COG2081	HI0933 family
T15_RS00990	COG2723	6-phospho-beta-galactosidase activity
T15_RS01000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
T15_RS01015	COG3959	Transketolase, thiamine diphosphate binding domain
T15_RS01020	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
T15_RS01025	COG0584	glycerophosphoryl diester phosphodiesterase
T15_RS01030	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
T15_RS01035	COG2222	sugar isomerase
T15_RS01045	COG2801	Transposase and inactivated derivatives
T15_RS01065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
T15_RS01080	COG1882	Formate acetyltransferase
T15_RS01095	COG2910	NAD(P)H-binding
T15_RS01105	COG2801	Transposase and inactivated derivatives
T15_RS01130	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
T15_RS01165	COG0363	glucosamine-6-phosphate deaminase activity
T15_RS01175	COG2217	Heavy metal translocating P-type atpase
T15_RS01180	COG2217	Heavy metal translocating P-type atpase
T15_RS01185	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
T15_RS01190	COG2801	Transposase and inactivated derivatives
T15_RS01200	COG0681	Belongs to the peptidase S26 family
T15_RS01220	COG2801	Transposase and inactivated derivatives
T15_RS01225	COG1115	amino acid carrier protein
T15_RS01230	COG1136	(ABC) transporter
T15_RS01240	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
T15_RS01240	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
T15_RS01245	COG0318	PFAM AMP-dependent synthetase and ligase
T15_RS01250	COG3118	belongs to the thioredoxin family
T15_RS01295	COG1193	negative regulation of DNA recombination
T15_RS01310	COG2188	Transcriptional regulator
T15_RS01315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
T15_RS01315	COG1263	PTS System
T15_RS01320	COG0366	Alpha amylase catalytic
T15_RS01330	COG2801	Transposase and inactivated derivatives
T15_RS01340	COG0668	transmembrane transport
T15_RS01355	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
T15_RS01360	COG0167	dihydroorotate dehydrogenase activity
T15_RS01370	COG0561	phosphatase activity
T15_RS01385	COG1131	(ABC) transporter
T15_RS01390	COG1309	transcriptional regulator
T15_RS01395	COG1511	domain protein
T15_RS01420	COG1346	cytolysis
T15_RS01425	COG2116	formate transmembrane transporter activity
T15_RS01430	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
T15_RS01435	COG0433	COG0433 Predicted ATPase
T15_RS01440	COG0494	nUDIX hydrolase
T15_RS01470	COG0267	Belongs to the bacterial ribosomal protein bL33 family
T15_RS01475	COG0333	Belongs to the bacterial ribosomal protein bL32 family
T15_RS01485	COG0124	histidyl-tRNA synthetase
T15_RS01490	COG1064	alcohol dehydrogenase
T15_RS01495	COG1454	alcohol dehydrogenase
T15_RS01495	COG1012	belongs to the aldehyde dehydrogenase family
T15_RS01505	COG4988	ABC transporter
T15_RS01510	COG1132	(ABC) transporter
T15_RS01525	COG1129	ABC transporter
T15_RS01530	COG0534	Mate efflux family protein
T15_RS01535	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
T15_RS01550	COG1304	FMN binding
T15_RS01565	COG1132	(ABC) transporter
T15_RS01570	COG1132	(ABC) transporter
T15_RS01575	COG3830	Belongs to the UPF0237 family
T15_RS01580	COG2848	UPF0210 protein
T15_RS01585	COG0588	phosphoglycerate mutase activity
T15_RS01600	COG1420	regulation of RNA biosynthetic process
T15_RS01605	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
T15_RS01610	COG0443	Heat shock 70 kDa protein
T15_RS01620	COG0484	heat shock protein binding
T15_RS01625	COG2801	Transposase and inactivated derivatives
T15_RS01635	COG0095	Lipoate-protein ligase
T15_RS01645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
T15_RS01675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
T15_RS01680	COG0765	amino acid transport
T15_RS01695	COG3655	Transcriptional regulator
T15_RS01705	COG2217	Heavy metal translocating P-type atpase
T15_RS01720	COG0351	phosphomethylpyrimidine kinase
T15_RS01730	COG4475	Protein of unknown function (DUF436)
T15_RS01760	COG4221	oxidoreductase activity
T15_RS01765	COG0446	pyridine nucleotide-disulphide oxidoreductase
T15_RS01765	COG1902	pentaerythritol trinitrate reductase activity
T15_RS01780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
T15_RS01800	COG0544	peptidyl-prolyl cis-trans isomerase activity
T15_RS01830	COG3343	RNA polymerase activity
T15_RS01835	COG0504	CTP synthase activity
T15_RS01845	COG0191	fructose-bisphosphate aldolase activity
T15_RS01850	COG0227	Belongs to the bacterial ribosomal protein bL28 family
T15_RS01895	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
T15_RS01900	COG0252	asparaginase activity
T15_RS01915	COG0589	response to stress
T15_RS01920	COG0436	Aminotransferase
T15_RS01925	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
T15_RS01930	COG1335	isochorismatase
T15_RS01935	COG0335	large ribosomal subunit rRNA binding
T15_RS01945	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
T15_RS01950	COG0154	amidase activity
T15_RS01955	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
T15_RS01960	COG1609	Transcriptional regulator
T15_RS01965	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
T15_RS01970	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
T15_RS01980	COG3142	Participates in the control of copper homeostasis
T15_RS01995	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
T15_RS02000	COG1534	Rna-binding protein
T15_RS02005	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
T15_RS02010	COG1713	HD superfamily hydrolase involved in NAD metabolism
T15_RS02020	COG1335	isochorismatase
T15_RS02025	COG0799	negative regulation of ribosome biogenesis
T15_RS02030	COG2226	methyltransferase
T15_RS02050	COG0789	Transcriptional regulator
T15_RS02055	COG2348	transferase activity, transferring amino-acyl groups
T15_RS02065	COG0242	peptide deformylase activity
T15_RS02075	COG1640	4-alpha-glucanotransferase
T15_RS02080	COG0058	SHG alpha-glucan phosphorylase activity
T15_RS02095	COG1263	PTS System
T15_RS02095	COG2190	(PTS) system
T15_RS02095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
T15_RS02110	COG0217	transcriptional regulatory protein
T15_RS02120	COG2801	Transposase and inactivated derivatives
T15_RS02130	COG4720	Psort location CytoplasmicMembrane, score
T15_RS02140	COG1054	Belongs to the UPF0176 family
T15_RS02150	COG1122	ATPase activity
T15_RS02165	COG0357	Ribosomal RNA small subunit methyltransferase G
T15_RS02170	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
T15_RS02175	COG3331	DNA recombination
T15_RS02180	COG4474	Belongs to the UPF0398 family
T15_RS02185	COG3599	regulation of cell shape
T15_RS02190	COG0116	Belongs to the methyltransferase superfamily
T15_RS02200	COG1854	S-ribosylhomocysteine lyase activity
T15_RS02205	COG1418	mRNA catabolic process
T15_RS02215	COG1758	RNA polymerase activity
T15_RS02220	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
T15_RS02225	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
T15_RS02230	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
T15_RS02230	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
T15_RS02235	COG0631	protein serine/threonine phosphatase activity
T15_RS02240	COG2815	serine threonine protein kinase
T15_RS02240	COG0515	serine threonine protein kinase
T15_RS02265	COG1098	S1 RNA binding domain
T15_RS02275	COG1739	Uncharacterized protein family UPF0029
T15_RS02280	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
T15_RS02360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
T15_RS02370	COG3557	Belongs to the UPF0374 family
T15_RS02380	COG2188	Transcriptional regulator
T15_RS02385	COG2188	Transcriptional regulator
T15_RS02395	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
T15_RS02405	COG3716	PTS system mannose fructose sorbose family IID component
T15_RS02415	COG2017	converts alpha-aldose to the beta-anomer
T15_RS02430	COG0346	lactoylglutathione lyase activity
T15_RS02445	COG0525	valine-tRNA ligase activity
T15_RS02495	COG2801	Transposase and inactivated derivatives
T15_RS02505	COG1217	gtp-binding protein TYPA
T15_RS02520	COG0681	Belongs to the peptidase S26 family
T15_RS02545	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
T15_RS02560	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
T15_RS02565	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
T15_RS02570	COG1799	cell septum assembly
T15_RS02585	COG3599	regulation of cell shape
T15_RS02605	COG0406	alpha-ribazole phosphatase activity
T15_RS02605	COG0494	nUDIX hydrolase
T15_RS02610	COG0542	response to heat
T15_RS02620	COG4703	Protein of unknown function (DUF1797)
T15_RS02625	COG0765	amino acid transport
T15_RS02635	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
T15_RS02670	COG0789	Transcriptional regulator
T15_RS02685	COG0826	peptidase U32
T15_RS02695	COG4443	Transcriptional Coactivator p15 (PC4)
T15_RS02705	COG1609	Transcriptional regulator
T15_RS02720	COG1175	transmembrane transport
T15_RS02725	COG3833	ABC-type maltose transport systems, permease component
T15_RS02735	COG1268	BioY protein
T15_RS02740	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
T15_RS02745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
T15_RS02750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
T15_RS02755	COG1136	(ABC) transporter
T15_RS02760	COG0577	efflux transmembrane transporter activity
T15_RS02770	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
T15_RS02780	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
T15_RS02790	COG3859	Proton-coupled thiamine transporter YuaJ
T15_RS02810	COG0772	Belongs to the SEDS family
T15_RS02815	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
T15_RS02830	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
T15_RS02835	COG0149	triose-phosphate isomerase activity
T15_RS02845	COG1078	dGTPase activity
T15_RS02880	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
T15_RS02885	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
T15_RS02890	COG2884	Cell division ATP-binding protein ftsE
T15_RS02895	COG2177	Part of the ABC transporter FtsEX involved in
T15_RS02925	COG1132	(ABC) transporter
T15_RS02930	COG1132	(ABC) transporter
T15_RS02935	COG1011	Hydrolase
T15_RS02945	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
T15_RS02955	COG1737	Transcriptional regulator
T15_RS02965	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
T15_RS02970	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
T15_RS02975	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
T15_RS02985	COG2814	Major facilitator Superfamily
T15_RS02990	COG0267	Belongs to the bacterial ribosomal protein bL33 family
T15_RS03000	COG0557	exoribonuclease II activity
T15_RS03005	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
T15_RS03010	COG1063	alcohol dehydrogenase
T15_RS03025	COG2217	Heavy metal translocating P-type atpase
T15_RS03030	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
T15_RS03040	COG1136	(ABC) transporter
T15_RS03055	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
T15_RS03055	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
T15_RS03065	COG1832	CoA-binding protein
T15_RS03075	COG2801	Transposase and inactivated derivatives
T15_RS03085	COG0343	queuine tRNA-ribosyltransferase activity
T15_RS03115	COG1940	carbohydrate kinase activity
T15_RS03120	COG2115	Belongs to the xylose isomerase family
T15_RS03125	COG1070	Carbohydrate kinase
T15_RS03140	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
T15_RS03145	COG3715	PTS system
T15_RS03150	COG3716	PTS system mannose fructose sorbose family IID component
T15_RS03165	COG1609	Transcriptional regulator
T15_RS03180	COG0438	transferase activity, transferring glycosyl groups
T15_RS03195	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
T15_RS03200	COG0765	amino acid transport
T15_RS03205	COG0765	amino acid transport
T15_RS03210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
T15_RS03220	COG0745	RESPONSE REGULATOR receiver
T15_RS03230	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
T15_RS03240	COG0768	penicillin binding
T15_RS03245	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
T15_RS03250	COG1181	Belongs to the D-alanine--D-alanine ligase family
T15_RS03260	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
T15_RS03270	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
T15_RS03280	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
T15_RS03300	COG1609	Transcriptional regulator
T15_RS03305	COG4209	transmembrane transport
T15_RS03310	COG0395	ABC-type sugar transport system, permease component
T15_RS03320	COG1621	beta-fructofuranosidase activity
T15_RS03325	COG0697	spore germination
T15_RS03325	COG1674	ftsk spoiiie
T15_RS03330	COG0346	lactoylglutathione lyase activity
T15_RS03355	COG0625	glutathione transferase activity
T15_RS03360	COG2244	polysaccharide biosynthetic process
T15_RS03365	COG0528	UMP kinase activity
T15_RS03370	COG0233	cytoplasmic translational termination
T15_RS03375	COG2996	Protein conserved in bacteria
T15_RS03390	COG4479	Belongs to the UPF0346 family
T15_RS03395	COG1702	phosphate starvation-inducible protein PhoH
T15_RS03400	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
T15_RS03405	COG2807	transmembrane transport
T15_RS03415	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
T15_RS03420	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
T15_RS03430	COG1234	tRNA 3'-trailer cleavage
T15_RS03435	COG0300	oxidoreductase activity
T15_RS03445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
T15_RS03450	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
T15_RS03450	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
T15_RS03460	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
T15_RS03475	COG2384	SAM-dependent methyltransferase
T15_RS03480	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
T15_RS03490	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
T15_RS03505	COG1088	dTDP-glucose 4,6-dehydratase activity
T15_RS03510	COG1091	dTDP-4-dehydrorhamnose reductase activity
T15_RS03540	COG1442	glycosyl transferase family 8
T15_RS03540	COG1216	Glycosyl transferase, family 2
T15_RS03570	COG1442	glycosyl transferase family 8
T15_RS03575	COG1442	glycosyl transferase family 8
T15_RS03575	COG1216	Glycosyl transferase, family 2
T15_RS03590	COG1216	Glycosyl transferase, family 2
T15_RS03620	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
T15_RS03630	COG0291	Belongs to the bacterial ribosomal protein bL35 family
T15_RS03645	COG1368	sulfuric ester hydrolase activity
T15_RS03650	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
T15_RS03655	COG0710	3-dehydroquinate dehydratase activity
T15_RS03660	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
T15_RS03665	COG0287	Prephenate dehydrogenase
T15_RS03670	COG3679	Belongs to the UPF0342 family
T15_RS03680	COG3684	Belongs to the aldolase LacD family
T15_RS03700	COG4120	Belongs to the binding-protein-dependent transport system permease family
T15_RS03705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
T15_RS03705	COG1116	anion transmembrane transporter activity
T15_RS03710	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
T15_RS03715	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
T15_RS03720	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
T15_RS03725	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
T15_RS03735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
T15_RS03735	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
T15_RS03760	COG4122	O-methyltransferase activity
T15_RS03765	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
T15_RS03775	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
T15_RS03800	COG1476	TRANSCRIPTIONal
T15_RS03835	COG1028	Short-chain dehydrogenase reductase Sdr
T15_RS03860	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
T15_RS03865	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
T15_RS03875	COG3716	PTS system mannose fructose sorbose family IID component
T15_RS03885	COG5492	domain, Protein
T15_RS03895	COG1609	Transcriptional regulator
T15_RS03900	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
T15_RS03905	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
T15_RS03910	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
T15_RS03915	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
T15_RS03920	COG0372	Belongs to the citrate synthase family
T15_RS03925	COG0538	isocitrate dehydrogenase activity
T15_RS03930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
T15_RS03970	COG1196	nuclear chromosome segregation
T15_RS03975	COG0561	phosphatase activity
T15_RS03980	COG0561	phosphatase activity
T15_RS03985	COG0552	protein localization to endoplasmic reticulum
T15_RS04000	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
T15_RS04005	COG3689	TIGRFAM TIGR03943 family protein
T15_RS04010	COG0701	Predicted permease
T15_RS04020	COG1597	lipid kinase activity
T15_RS04030	COG0356	it plays a direct role in the translocation of protons across the membrane
T15_RS04035	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
T15_RS04040	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
T15_RS04045	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
T15_RS04050	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
T15_RS04055	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
T15_RS04060	COG0355	proton-transporting ATP synthase activity, rotational mechanism
T15_RS04070	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
T15_RS04085	COG2211	Major facilitator Superfamily
T15_RS04095	COG3250	beta-galactosidase activity
T15_RS04105	COG0800	Aldolase
T15_RS04115	COG1312	Catalyzes the dehydration of D-mannonate
T15_RS04120	COG1028	Short-chain dehydrogenase reductase Sdr
T15_RS04150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
T15_RS04150	COG0072	phenylalanine-tRNA ligase activity
T15_RS04165	COG2801	Transposase and inactivated derivatives
T15_RS04175	COG5002	protein histidine kinase activity
T15_RS04180	COG0745	RESPONSE REGULATOR receiver
T15_RS04190	COG0704	Plays a role in the regulation of phosphate uptake
T15_RS04195	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
T15_RS04200	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
T15_RS04205	COG0581	inorganic phosphate transmembrane transporter activity
T15_RS04210	COG0573	inorganic phosphate transmembrane transporter activity
T15_RS04220	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
T15_RS04220	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
T15_RS04225	COG0483	inositol monophosphate 1-phosphatase activity
T15_RS04230	COG4476	Belongs to the UPF0223 family
T15_RS04235	COG1393	Belongs to the ArsC family
T15_RS04245	COG0196	riboflavin kinase activity
T15_RS04250	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
T15_RS04290	COG0561	phosphatase activity
T15_RS04295	COG2195	Cleaves the N-terminal amino acid of tripeptides
T15_RS04310	COG1695	Transcriptional regulator
T15_RS04320	COG3759	membrane
T15_RS04325	COG1846	Transcriptional regulator
T15_RS04340	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
T15_RS04345	COG2610	gluconate transmembrane transporter activity
T15_RS04365	COG0302	gtp cyclohydrolase
T15_RS04370	COG1051	belongs to the nudix hydrolase family
T15_RS04390	COG2801	Transposase and inactivated derivatives
T15_RS04405	COG1072	(Pantothenic acid kinase))
T15_RS04410	COG2813	Specifically methylates the guanine in position
T15_RS04415	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
T15_RS04430	COG1744	ABC transporter substrate-binding protein PnrA-like
T15_RS04435	COG3845	ABC transporter
T15_RS04440	COG4603	Belongs to the binding-protein-dependent transport system permease family
T15_RS04445	COG1079	Belongs to the binding-protein-dependent transport system permease family
T15_RS04450	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
T15_RS04455	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
T15_RS04460	COG0039	L-malate dehydrogenase activity
T15_RS04465	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
T15_RS04470	COG3764	Sortase (surface protein transpeptidase)
T15_RS04480	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
T15_RS04485	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
T15_RS04500	COG1104	cysteine desulfurase activity
T15_RS04510	COG4116	CYTH
T15_RS04515	COG2357	RelA SpoT domain protein
T15_RS04520	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
T15_RS04525	COG0564	pseudouridine synthase activity
T15_RS04530	COG0280	phosphate acetyltransferase
T15_RS04540	COG1132	(ABC) transporter
T15_RS04550	COG1194	a g-specific adenine glycosylase
T15_RS04555	COG1396	sequence-specific DNA binding
T15_RS04585	COG1349	DNA-binding transcription factor activity
T15_RS04590	COG0698	ribose 5-phosphate isomerase
T15_RS04595	COG0698	ribose 5-phosphate isomerase
T15_RS04600	COG1105	Belongs to the carbohydrate kinase PfkB family
T15_RS04605	COG3684	Belongs to the aldolase LacD family
T15_RS04690	COG0582	viral genome integration into host DNA
T15_RS04700	COG3711	transcriptional antiterminator
T15_RS04710	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
T15_RS04710	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
T15_RS04735	COG2873	o-acetylhomoserine
T15_RS04740	COG0488	(ABC) transporter
T15_RS04750	COG1126	abc transporter atp-binding protein
T15_RS04765	COG3583	domain protein
T15_RS04790	COG0270	DNA (cytosine-5-)-methyltransferase activity
T15_RS04845	COG1705	Flagellar rod assembly protein muramidase FlgJ
T15_RS04845	COG3942	CHAP domain
T15_RS04895	COG1396	sequence-specific DNA binding
T15_RS04920	COG3842	ATPase activity
T15_RS04940	COG2801	Transposase and inactivated derivatives
T15_RS04950	COG4804	nuclease activity
T15_RS04960	COG1484	DNA-dependent DNA replication
T15_RS05060	COG3843	relaxase mobilization nuclease domain protein
T15_RS05120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
T15_RS05130	COG0297	glycogen (starch) synthase activity
T15_RS05140	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
T15_RS05155	COG0167	dihydroorotate dehydrogenase activity
T15_RS05160	COG0284	orotidine-5'-phosphate decarboxylase activity
T15_RS05165	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
T15_RS05175	COG0463	Glycosyl transferase, family 2
T15_RS05180	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
T15_RS05190	COG0737	Belongs to the 5'-nucleotidase family
T15_RS05250	COG1705	Flagellar rod assembly protein muramidase FlgJ
T15_RS05250	COG3942	CHAP domain
T15_RS05275	COG0270	DNA (cytosine-5-)-methyltransferase activity
T15_RS05295	COG0629	single-stranded DNA binding
T15_RS05305	COG5290	Psort location Cytoplasmic, score
T15_RS05325	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
T15_RS05350	COG1070	Carbohydrate kinase
T15_RS05350	COG4806	L-rhamnose isomerase
T15_RS05370	COG1175	transmembrane transport
T15_RS05390	COG1940	carbohydrate kinase activity
T15_RS05400	COG1396	sequence-specific DNA binding
T15_RS05410	COG0582	viral genome integration into host DNA
T15_RS05415	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
T15_RS05420	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
T15_RS05430	COG1272	protein, Hemolysin III
T15_RS05440	COG0446	pyridine nucleotide-disulphide oxidoreductase
T15_RS05450	COG1937	Protein conserved in bacteria
T15_RS05455	COG0110	maltose O-acetyltransferase activity
T15_RS05460	COG0758	DNA mediated transformation
T15_RS05465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
T15_RS05470	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
T15_RS05475	COG0222	ribosome binding
T15_RS05480	COG0647	UMP catabolic process
T15_RS05485	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
T15_RS05495	COG2382	esterase
T15_RS05535	COG1136	(ABC) transporter
T15_RS05555	COG0745	RESPONSE REGULATOR receiver
T15_RS05570	COG4974	Belongs to the 'phage' integrase family
T15_RS05585	COG1660	Displays ATPase and GTPase activities
T15_RS05600	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
T15_RS05605	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
T15_RS05610	COG2188	Transcriptional regulator
T15_RS05625	COG1401	restriction endodeoxyribonuclease activity
T15_RS05650	COG4221	oxidoreductase activity
T15_RS05655	COG0741	lytic transglycosylase activity
T15_RS05665	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
T15_RS05675	COG0009	L-threonylcarbamoyladenylate synthase
T15_RS05680	COG2890	protein-(glutamine-N5) methyltransferase activity
T15_RS05685	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
T15_RS05715	COG0481	GTPase activity
T15_RS05730	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
T15_RS05740	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
T15_RS05745	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
T15_RS05760	COG1940	carbohydrate kinase activity
T15_RS05770	COG0488	(ABC) transporter
T15_RS05775	COG0617	tRNA 3'-terminal CCA addition
T15_RS05780	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
T15_RS05785	COG1307	EDD domain protein, DegV family
T15_RS05795	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
T15_RS05795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
T15_RS05795	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
T15_RS05800	COG1105	Belongs to the carbohydrate kinase PfkB family
T15_RS05805	COG1349	DNA-binding transcription factor activity
T15_RS05810	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
T15_RS05815	COG0336	Belongs to the RNA methyltransferase TrmD family
T15_RS05820	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
T15_RS05825	COG0534	Mate efflux family protein
T15_RS05835	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
T15_RS05840	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
T15_RS05855	COG0038	chloride channel
T15_RS05865	COG1177	transmembrane transport
T15_RS05870	COG1176	ABC-type spermidine putrescine transport system, permease component I
T15_RS05875	COG3842	ATPase activity
T15_RS05880	COG0812	UDP-N-acetylmuramate dehydrogenase activity
T15_RS05885	COG0083	homoserine kinase activity
T15_RS05890	COG0460	homoserine dehydrogenase
T15_RS05895	COG0726	polysaccharide deacetylase
T15_RS05900	COG1132	(ABC) transporter
T15_RS05915	COG0228	four-way junction DNA binding
T15_RS05925	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
T15_RS05930	COG2521	methyltransferase
T15_RS05930	COG2136	Putative SAM-dependent methyltransferase
T15_RS05940	COG0505	Belongs to the CarA family
T15_RS05945	COG0540	Belongs to the ATCase OTCase family
T15_RS05950	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
T15_RS05960	COG2824	Alkylphosphonate utilization operon protein PhnA
T15_RS05965	COG0564	pseudouridine synthase activity
T15_RS05985	COG0211	Belongs to the bacterial ribosomal protein bL27 family
T15_RS05990	COG0261	This protein binds to 23S rRNA in the presence of protein L20
T15_RS05995	COG1114	Component of the transport system for branched-chain amino acids
T15_RS06000	COG0301	tRNA thio-modification
T15_RS06005	COG1104	cysteine desulfurase activity
T15_RS06025	COG2801	Transposase and inactivated derivatives
T15_RS06140	COG0582	viral genome integration into host DNA
T15_RS06220	COG3561	AntA/AntB antirepressor
T15_RS06280	COG0539	negative regulation of cytoplasmic translation
T15_RS06300	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
T15_RS06310	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
T15_RS06320	COG2184	nucleotidyltransferase activity
T15_RS06330	COG0187	DNA topoisomerase II activity
T15_RS06340	COG1074	ATP-dependent DNA helicase activity
T15_RS06345	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
T15_RS06375	COG1131	(ABC) transporter
T15_RS06400	COG2801	Transposase and inactivated derivatives
T15_RS06415	COG1011	Hydrolase
T15_RS06425	COG0210	DNA helicase
T15_RS06430	COG3177	Filamentation induced by cAMP protein fic
T15_RS06445	COG1164	Oligoendopeptidase f
T15_RS06455	COG0346	lactoylglutathione lyase activity
T15_RS06460	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
T15_RS06465	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
T15_RS06470	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
T15_RS06480	COG0446	pyridine nucleotide-disulphide oxidoreductase
T15_RS06485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
T15_RS06490	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
T15_RS06530	COG0732	type I restriction modification DNA specificity domain
T15_RS06540	COG2801	Transposase and inactivated derivatives
T15_RS06555	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
T15_RS06560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
T15_RS06570	COG2759	Belongs to the formate--tetrahydrofolate ligase family
T15_RS06580	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
T15_RS06585	COG4684	Psort location CytoplasmicMembrane, score
T15_RS06590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
T15_RS06630	COG0531	amino acid
T15_RS06640	COG0708	Exodeoxyribonuclease III
T15_RS06650	COG1393	Belongs to the ArsC family
T15_RS06655	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
T15_RS06660	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
T15_RS06670	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
T15_RS06680	COG4467	Involved in initiation control of chromosome replication
T15_RS06685	COG0470	DNA polymerase III
T15_RS06690	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
T15_RS06695	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
T15_RS06710	COG0517	IMP dehydrogenase activity
T15_RS06715	COG2333	competence protein COMEC
T15_RS06715	COG0658	competence protein
T15_RS06720	COG1596	polysaccharide export
T15_RS06720	COG1555	photosystem II stabilization
T15_RS06725	COG0204	Acyl-transferase
T15_RS06730	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
T15_RS06735	COG1120	ATPase activity
T15_RS06740	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
T15_RS06745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
T15_RS06750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
T15_RS06755	COG0386	Belongs to the glutathione peroxidase family
T15_RS06760	COG1187	pseudouridine synthase activity
T15_RS06765	COG0435	Glutathione S-transferase
T15_RS06775	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
T15_RS06780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
T15_RS06785	COG1696	Membrane protein involved in D-alanine export
T15_RS06810	COG2801	Transposase and inactivated derivatives
T15_RS06825	COG0363	glucosamine-6-phosphate deaminase activity
T15_RS06830	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
T15_RS06835	COG1438	arginine binding
T15_RS06840	COG3583	domain protein
T15_RS06840	COG3525	Glycosyl hydrolase, family 20, catalytic domain
T15_RS06840	COG3064	Membrane
T15_RS06845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
T15_RS06850	COG1288	antiporter activity
T15_RS06855	COG0549	Belongs to the carbamate kinase family
T15_RS06860	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
T15_RS06865	COG0454	-acetyltransferase
T15_RS06880	COG1481	regulation of sporulation
T15_RS06885	COG0391	Required for morphogenesis under gluconeogenic growth conditions
T15_RS06890	COG1660	Displays ATPase and GTPase activities
T15_RS06895	COG0251	oxidation-reduction process
T15_RS06900	COG0534	Mate efflux family protein
T15_RS06920	COG0436	Aminotransferase
T15_RS06945	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
T15_RS06950	COG0562	UDP-galactopyranose mutase
T15_RS06955	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
T15_RS06965	COG0077	Prephenate dehydratase
T15_RS06970	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
T15_RS07050	COG2755	lipolytic protein G-D-S-L family
T15_RS07050	COG1083	cytidylyl-transferase
T15_RS07065	COG2089	acid synthase
T15_RS07095	COG1216	Glycosyl transferase, family 2
T15_RS07095	COG1442	glycosyl transferase family 8
T15_RS07100	COG1442	glycosyl transferase family 8
T15_RS07100	COG1216	Glycosyl transferase, family 2
T15_RS07115	COG0438	transferase activity, transferring glycosyl groups
T15_RS07130	COG4464	protein tyrosine phosphatase activity
T15_RS07140	COG3944	biosynthesis protein
T15_RS07150	COG3022	response to hydroperoxide
T15_RS07155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
T15_RS07170	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
T15_RS07175	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
T15_RS07180	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
T15_RS07195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
T15_RS07200	COG1126	abc transporter atp-binding protein
T15_RS07205	COG0765	amino acid transport
T15_RS07210	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
T15_RS07220	COG2755	lipolytic protein G-D-S-L family
T15_RS07220	COG0657	acetylesterase activity
T15_RS07225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
T15_RS07235	COG0469	pyruvate kinase activity
T15_RS07240	COG0205	6-phosphofructokinase activity
T15_RS07250	COG2188	Transcriptional regulator
T15_RS07255	COG1131	(ABC) transporter
T15_RS07265	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
T15_RS07270	COG2826	transposase and inactivated derivatives, IS30 family
T15_RS07290	COG5433	transposase activity
T15_RS07300	COG2151	metal-sulfur cluster biosynthetic enzyme
T15_RS07305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
T15_RS07310	COG0358	DNA primase activity
T15_RS07315	COG1970	mechanosensitive ion channel activity
T15_RS07320	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
T15_RS07325	COG0828	Belongs to the bacterial ribosomal protein bS21 family
T15_RS07335	COG0647	UMP catabolic process
T15_RS07340	COG1051	belongs to the nudix hydrolase family
T15_RS07350	COG0635	Involved in the biosynthesis of porphyrin-containing compound
T15_RS07360	COG0058	SHG alpha-glucan phosphorylase activity
T15_RS07365	COG0813	purine-nucleoside phosphorylase activity
T15_RS07370	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
T15_RS07380	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
T15_RS07385	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
T15_RS07390	COG1204	response to ionizing radiation
T15_RS07400	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
T15_RS07415	COG2268	Band 7 protein
T15_RS07420	COG1704	LemA family
T15_RS07430	COG1573	uracil-dna glycosylase
T15_RS07465	COG2226	methyltransferase
T15_RS07470	COG0488	(ABC) transporter
T15_RS07475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
T15_RS07490	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
T15_RS07495	COG3442	glutamine amidotransferase
T15_RS07500	COG2226	methyltransferase
T15_RS07510	COG0488	(ABC) transporter
T15_RS07565	COG1263	PTS System
T15_RS07565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
T15_RS07565	COG2190	(PTS) system
T15_RS07570	COG3711	transcriptional antiterminator
T15_RS07575	COG1293	RNA-binding protein homologous to eukaryotic snRNP
T15_RS07580	COG5002	protein histidine kinase activity
T15_RS07585	COG0745	RESPONSE REGULATOR receiver
T15_RS07595	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
T15_RS07600	COG0581	inorganic phosphate transmembrane transporter activity
T15_RS07605	COG0573	inorganic phosphate transmembrane transporter activity
T15_RS07615	COG2801	Transposase and inactivated derivatives
T15_RS07625	COG3527	Alpha-acetolactate decarboxylase
T15_RS07635	COG0628	permease
T15_RS07640	COG2706	6-phosphogluconolactonase activity
T15_RS07650	COG1011	Hydrolase
T15_RS07680	COG0560	Phosphoserine phosphatase
T15_RS07685	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
T15_RS07690	COG0187	DNA topoisomerase II activity
T15_RS07695	COG0693	protein deglycase activity
T15_RS07700	COG0772	Belongs to the SEDS family
T15_RS07715	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
T15_RS07720	COG0716	FMN binding
T15_RS07730	COG1605	Chorismate mutase
T15_RS07730	COG0287	Prephenate dehydrogenase
T15_RS07735	COG0038	chloride channel
T15_RS07745	COG0737	Belongs to the 5'-nucleotidase family
T15_RS07750	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
T15_RS07755	COG1466	dna polymerase III delta subunit
T15_RS07790	COG0683	leucine binding
T15_RS07805	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
T15_RS07810	COG0366	Alpha amylase catalytic
T15_RS07820	COG0395	ABC-type sugar transport system, permease component
T15_RS07825	COG1175	transmembrane transport
T15_RS07830	COG1653	transport
T15_RS07840	COG2207	Transcriptional regulator
T15_RS07845	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
T15_RS07850	COG0626	cystathionine gamma-synthase activity
T15_RS07870	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
T15_RS07875	COG2827	Endonuclease containing a URI domain
T15_RS07895	COG0640	Transcriptional regulator
T15_RS07900	COG0513	Belongs to the DEAD box helicase family
T15_RS07905	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
T15_RS07945	COG0494	nUDIX hydrolase
T15_RS07950	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
T15_RS07960	COG1028	Short-chain dehydrogenase reductase Sdr
T15_RS07970	COG0582	viral genome integration into host DNA
T15_RS08080	COG0577	efflux transmembrane transporter activity
T15_RS08085	COG1136	(ABC) transporter
T15_RS08105	COG0436	Aminotransferase
T15_RS08130	COG1174	glycine betaine transport
T15_RS08135	COG1125	glycine betaine transport
T15_RS08135	COG0517	IMP dehydrogenase activity
T15_RS08155	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
T15_RS08160	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
T15_RS08165	COG1482	cell wall glycoprotein biosynthetic process
T15_RS08180	COG3091	SprT-like family
T15_RS08185	COG2183	response to ionizing radiation
T15_RS08190	COG0656	L-ascorbic acid biosynthetic process
T15_RS08195	COG4708	membrane
T15_RS08200	COG2246	polysaccharide biosynthetic process
T15_RS08210	COG0024	Methionine aminopeptidase
T15_RS08220	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
T15_RS08225	COG2249	NAD(P)H dehydrogenase (quinone) activity
T15_RS08230	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
T15_RS08235	COG2131	deaminase
T15_RS08245	COG1363	Peptidase, m42
T15_RS08260	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
T15_RS08265	COG1956	GAF domain-containing protein
T15_RS08275	COG1695	Transcriptional regulator
T15_RS08285	COG0673	inositol 2-dehydrogenase activity
T15_RS08290	COG0513	Belongs to the DEAD box helicase family
T15_RS08310	COG0183	Belongs to the thiolase family
T15_RS08315	COG3425	synthase
T15_RS08590	COG0582	viral genome integration into host DNA
T15_RS08595	COG0776	regulation of translation
T15_RS08605	COG2755	lipolytic protein G-D-S-L family
T15_RS08610	COG1307	EDD domain protein, DegV family
T15_RS08615	COG0497	DNA recombination
T15_RS08620	COG1438	arginine binding
T15_RS08625	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
T15_RS08635	COG1722	exodeoxyribonuclease VII activity
T15_RS08640	COG1570	exodeoxyribonuclease VII activity
T15_RS08645	COG2321	neutral zinc metallopeptidase
T15_RS08650	COG1755	Isoprenylcysteine carboxyl methyltransferase
T15_RS08655	COG5002	protein histidine kinase activity
T15_RS08660	COG0745	RESPONSE REGULATOR receiver
T15_RS08680	COG1227	inorganic diphosphatase activity
T15_RS08690	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
T15_RS08695	COG1253	flavin adenine dinucleotide binding
T15_RS08700	COG1119	ATPase activity
T15_RS08705	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
T15_RS08715	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
T15_RS08720	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
T15_RS08725	COG0133	tryptophan synthase activity
T15_RS08740	COG4470	Protein conserved in bacteria
T15_RS08745	COG3480	Lon protease (S16) C-terminal proteolytic domain
T15_RS08750	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
T15_RS08755	COG0742	ribosomal rna small subunit methyltransferase
T15_RS08765	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
T15_RS08770	COG4483	Protein conserved in bacteria
T15_RS08775	COG2197	response regulator
T15_RS08780	COG4585	Histidine kinase
T15_RS08785	COG0842	Transport permease protein
T15_RS08805	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
T15_RS08820	COG0671	phosphoesterase, PA-phosphatase related
T15_RS08825	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
T15_RS08840	COG0747	negative chemotaxis
T15_RS08845	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
T15_RS08850	COG1187	pseudouridine synthase activity
T15_RS08855	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
T15_RS08860	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
T15_RS08865	COG0582	viral genome integration into host DNA
T15_RS08885	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
T15_RS08890	COG3763	UPF0154 protein
T15_RS08900	COG3579	cysteine-type endopeptidase activity
T15_RS08915	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
T15_RS08920	COG1254	Belongs to the acylphosphatase family
T15_RS08925	COG0706	membrane insertase activity
T15_RS08930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
T15_RS08935	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
T15_RS08945	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
T15_RS08955	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
T15_RS08970	COG1160	GTP binding
T15_RS08980	COG1484	DNA-dependent DNA replication
T15_RS08990	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
T15_RS08995	COG0628	permease
T15_RS09010	COG0745	RESPONSE REGULATOR receiver
T15_RS09015	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
T15_RS09025	COG0492	ferredoxin-NADP+ reductase activity
T15_RS09035	COG0513	Belongs to the DEAD box helicase family
T15_RS09045	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
T15_RS09050	COG0768	penicillin binding
T15_RS09060	COG0275	rRNA processing
T15_RS09105	COG4939	FMN-binding domain protein
T15_RS09110	COG0142	geranyltranstransferase activity
T15_RS09115	COG1252	NADH dehydrogenase
T15_RS09130	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
T15_RS09135	COG0569	domain protein
T15_RS09140	COG0534	Mate efflux family protein
T15_RS09150	COG4224	UPF0291 protein
T15_RS09160	COG0751	glycine-tRNA ligase activity
T15_RS09185	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
T15_RS09190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
T15_RS09195	COG1464	Belongs to the NlpA lipoprotein family
T15_RS09200	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
T15_RS09205	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
T15_RS09210	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
T15_RS09215	COG2252	PERMEase
T15_RS09220	COG0561	phosphatase activity
T15_RS09230	COG3715	PTS system
T15_RS09235	COG3716	PTS system mannose fructose sorbose family IID component
T15_RS09260	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
T15_RS09300	COG0439	Biotin carboxylase
T15_RS09320	COG1028	Short-chain dehydrogenase reductase Sdr
T15_RS09325	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
T15_RS09330	COG2070	2-Nitropropane dioxygenase
T15_RS09340	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
T15_RS09350	COG1024	Enoyl-CoA hydratase
T15_RS09365	COG2801	Transposase and inactivated derivatives
T15_RS09375	COG0527	aspartate kinase activity
T15_RS09385	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
T15_RS09390	COG0736	holo-[acyl-carrier-protein] synthase activity
T15_RS09395	COG0653	protein targeting
T15_RS09405	COG1940	carbohydrate kinase activity
T15_RS09410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
T15_RS09410	COG1263	PTS System
T15_RS09410	COG2190	(PTS) system
T15_RS09415	COG1621	beta-fructofuranosidase activity
T15_RS09420	COG1609	Transcriptional regulator
T15_RS09425	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
T15_RS09440	COG0006	proline dipeptidase activity
T15_RS09445	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
T15_RS09460	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
T15_RS09465	COG0629	single-stranded DNA binding
T15_RS09475	COG0095	Lipoate-protein ligase
T15_RS09485	COG2801	Transposase and inactivated derivatives
T15_RS09500	COG0508	dehydrogenase complex catalyzes the overall conversion of
T15_RS09505	COG0508	dehydrogenase complex catalyzes the overall conversion of
T15_RS09505	COG0022	dehydrogenase e1 component
T15_RS09510	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
T15_RS09515	COG2860	membrane
T15_RS09530	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
T15_RS09535	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
T15_RS09545	COG2740	Nucleic-acid-binding protein implicated in transcription termination
T15_RS09550	COG0195	Participates in both transcription termination and antitermination
T15_RS09565	COG0220	tRNA (guanine-N7-)-methyltransferase activity
T15_RS09575	COG4473	ABC transporter
T15_RS09580	COG1131	(ABC) transporter
T15_RS09585	COG0537	adenosine 5'-monophosphoramidase activity
T15_RS09595	COG1316	TRANSCRIPTIONal
T15_RS09605	COG0802	atpase or kinase
T15_RS09610	COG1461	Dihydroxyacetone kinase
T15_RS09630	COG2801	Transposase and inactivated derivatives
T15_RS09640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
T15_RS09645	COG0601	transmembrane transport
T15_RS09650	COG4608	Belongs to the ABC transporter superfamily
T15_RS09665	COG1686	Belongs to the peptidase S11 family
T15_RS09680	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
T15_RS09685	COG0719	Fe-S assembly protein
T15_RS09695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
T15_RS09700	COG4862	establishment of competence for transformation
T15_RS09705	COG1968	undecaprenyl-diphosphatase activity
T15_RS09710	COG0765	amino acid transport
T15_RS09730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
T15_RS09735	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
T15_RS09740	COG0440	acetolactate synthase activity
T15_RS09745	COG0028	Belongs to the TPP enzyme family
T15_RS09750	COG0463	Glycosyl transferase, family 2
T15_RS09765	COG0129	dihydroxy-acid dehydratase activity
T15_RS09775	COG2151	metal-sulfur cluster biosynthetic enzyme
T15_RS09800	COG1674	ftsk spoiiie
T15_RS09825	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
T15_RS09855	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
T15_RS09870	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
T15_RS09890	COG3842	ATPase activity
T15_RS09900	COG4753	response regulator
T15_RS09900	COG2207	Transcriptional regulator
T15_RS09905	COG2972	Histidine kinase
T15_RS09915	COG1653	transport
T15_RS09920	COG0395	ABC-type sugar transport system, permease component
T15_RS09925	COG1175	transmembrane transport
T15_RS09940	COG0383	alpha-mannosidase activity
T15_RS09960	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
T15_RS09980	COG1045	serine acetyltransferase
T15_RS09985	COG1185	polyribonucleotide nucleotidyltransferase activity
T15_RS10000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
T15_RS10000	COG1263	PTS System
T15_RS10010	COG1737	Transcriptional regulator
T15_RS10015	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
T15_RS10045	COG0464	growth
T15_RS10055	COG1187	pseudouridine synthase activity
T15_RS10070	COG0242	peptide deformylase activity
T15_RS10080	COG0066	3-isopropylmalate dehydratase activity
T15_RS10105	COG2309	aminopeptidase activity
T15_RS10120	COG2176	DNA-directed DNA polymerase activity
T15_RS10125	COG2376	Dihydroxyacetone kinase
T15_RS10135	COG2376	Dihydroxyacetone kinase
T15_RS10140	COG1461	Dihydroxyacetone kinase
T15_RS10145	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
T15_RS10150	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
T15_RS10155	COG0442	prolyl-tRNA aminoacylation
T15_RS10165	COG4589	Belongs to the CDS family
T15_RS10170	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
T15_RS10175	COG1862	Preprotein translocase
T15_RS10185	COG1181	Belongs to the D-alanine--D-alanine ligase family
T15_RS10185	COG2918	glutathione biosynthetic process
T15_RS10195	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
T15_RS10200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
T15_RS10210	COG0542	response to heat
T15_RS10215	COG4463	regulation of RNA biosynthetic process
T15_RS10230	COG4932	domain protein
T15_RS10230	COG1388	LysM domain
T15_RS10235	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
T15_RS10270	COG0267	Belongs to the bacterial ribosomal protein bL33 family
T15_RS10275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
T15_RS10280	COG0492	ferredoxin-NADP+ reductase activity
T15_RS10285	COG0564	pseudouridine synthase activity
T15_RS10290	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
T15_RS10310	COG1564	THIamine pyrophosphokinase
T15_RS10320	COG1162	GTPase activity
T15_RS10355	COG4115	mRNA cleavage
T15_RS10390	COG0084	hydrolase, TatD family'
T15_RS10405	COG1847	R3H domain protein
T15_RS10415	COG0594	ribonuclease P activity
T15_RS10420	COG0165	Argininosuccinate lyase
T15_RS10425	COG0137	argininosuccinate synthase activity
T15_RS10435	COG1827	regulation of RNA biosynthetic process
T15_RS10490	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
T15_RS10500	COG0756	dUTP diphosphatase activity
T15_RS10505	COG1132	(ABC) transporter
T15_RS10510	COG1132	(ABC) transporter
T15_RS10520	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
T15_RS10525	COG1210	Utp--glucose-1-phosphate uridylyltransferase
T15_RS10530	COG0705	Rhomboid family
T15_RS10540	COG1473	amidohydrolase
T15_RS10545	COG2171	N-acyltransferase activity
T15_RS10550	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
T15_RS10570	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
T15_RS10595	COG3623	hexulose-6-phosphate isomerase
T15_RS10620	COG1523	belongs to the glycosyl hydrolase 13 family
T15_RS10630	COG2801	Transposase and inactivated derivatives
T15_RS10635	COG1609	Transcriptional regulator
T15_RS10640	COG1126	abc transporter atp-binding protein
T15_RS10645	COG0765	amino acid transport
T15_RS10650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
T15_RS10655	COG3942	CHAP domain
T15_RS10660	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
T15_RS10670	COG1447	Phosphotransferase system cellobiose-specific component IIA
T15_RS10680	COG3711	transcriptional antiterminator
T15_RS10680	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
T15_RS10690	COG2723	6-phospho-beta-galactosidase activity
T15_RS10695	COG1486	melibiose metabolic process
T15_RS10705	COG4667	esterase of the alpha-beta hydrolase superfamily
T15_RS10710	COG3590	peptidase
T15_RS10715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
T15_RS10720	COG1321	iron dependent repressor
T15_RS10720	COG1108	ABC-type Mn2 Zn2 transport systems permease components
T15_RS10725	COG1121	(ABC) transporter
T15_RS10740	COG0803	Belongs to the bacterial solute-binding protein 9 family
T15_RS10760	COG1490	D-aminoacyl-tRNA deacylase activity
T15_RS10790	COG1385	rRNA (uridine-N3-)-methyltransferase activity
T15_RS10815	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
T15_RS10840	COG0737	Belongs to the 5'-nucleotidase family
T15_RS10850	COG1328	CTP reductase activity
T15_RS10880	COG1438	arginine binding
T15_RS10885	COG0018	arginyl-trna synthetase
T15_RS10905	COG1640	4-alpha-glucanotransferase
T15_RS10910	COG2182	Extracellular solute-binding protein
T15_RS10915	COG1175	transmembrane transport
T15_RS10920	COG3833	ABC-type maltose transport systems, permease component
T15_RS10925	COG5521	maltodextrose utilization protein MalA
T15_RS10930	COG1609	Transcriptional regulator
T15_RS10935	COG1523	belongs to the glycosyl hydrolase 13 family
T15_RS10940	COG1780	Probably involved in ribonucleotide reductase function
T15_RS10945	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
T15_RS10950	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
T15_RS10955	COG2153	protein acetylation
T15_RS10960	COG4989	oxidoreductase activity
T15_RS10965	COG1216	Glycosyl transferase, family 2
T15_RS10970	COG1472	Belongs to the glycosyl hydrolase 3 family
T15_RS11010	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
T15_RS11025	COG0305	Participates in initiation and elongation during chromosome replication
T15_RS11030	COG0359	binds to the 23S rRNA
T15_RS11040	COG0445	tRNA wobble uridine modification
T15_RS11055	COG1051	belongs to the nudix hydrolase family
T15_RS11060	COG1733	regulation of RNA biosynthetic process
T15_RS11070	COG0482	sulfurtransferase activity
T15_RS11075	COG1760	l-serine dehydratase
T15_RS11080	COG1760	l-serine dehydratase
T15_RS11090	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
T15_RS11095	COG1122	ATPase activity
T15_RS11100	COG1122	ATPase activity
T15_RS11105	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
T15_RS11110	COG1426	Protein conserved in bacteria
T15_RS11115	COG0612	Peptidase, M16
T15_RS11120	COG0612	Peptidase, M16
T15_RS11130	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
T15_RS11135	COG0516	GMP reductase activity
T15_RS11135	COG0517	IMP dehydrogenase activity
T15_RS11145	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
T15_RS11150	COG0488	(ABC) transporter
T15_RS11180	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
T15_RS11185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
T15_RS11190	COG1475	DNA binding