locus-tag	class	description
TL13_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TL13_RS00010	COG0592	DNA-directed DNA polymerase activity
TL13_RS00030	COG0012	GTP binding
TL13_RS00035	COG0193	aminoacyl-tRNA hydrolase activity
TL13_RS00040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TL13_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TL13_RS00065	COG0037	tRNA processing
TL13_RS00075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TL13_RS00185	COG1792	Involved in formation and maintenance of cell shape
TL13_RS00200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TL13_RS00205	COG0436	Aminotransferase
TL13_RS00210	COG1381	Involved in DNA repair and RecF pathway recombination
TL13_RS00215	COG0416	fatty acid biosynthetic process
TL13_RS00220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TL13_RS00230	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TL13_RS00245	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TL13_RS00250	COG0138	bifunctional purine biosynthesis protein purh
TL13_RS00260	COG0151	Belongs to the GarS family
TL13_RS00265	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TL13_RS00305	COG1131	(ABC) transporter
TL13_RS00320	COG2255	four-way junction helicase activity
TL13_RS00325	COG0546	phosphoglycolate phosphatase activity
TL13_RS00335	COG0285	dihydrofolate synthase activity
TL13_RS00350	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TL13_RS00355	COG0632	four-way junction helicase activity
TL13_RS00360	COG0519	Catalyzes the synthesis of GMP from XMP
TL13_RS00375	COG1393	Belongs to the ArsC family
TL13_RS00380	COG4472	Bacterial protein of unknown function (DUF965)
TL13_RS00385	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TL13_RS00390	COG3906	Belongs to the UPF0473 family
TL13_RS00405	COG0051	transcription antitermination factor activity, RNA binding
TL13_RS00410	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TL13_RS00415	COG0088	Forms part of the polypeptide exit tunnel
TL13_RS00420	COG0089	rRNA binding
TL13_RS00425	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TL13_RS00430	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TL13_RS00435	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TL13_RS00440	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TL13_RS00445	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TL13_RS00450	COG0255	Belongs to the universal ribosomal protein uL29 family
TL13_RS00455	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TL13_RS00460	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TL13_RS00465	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TL13_RS00470	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TL13_RS00475	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TL13_RS00480	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TL13_RS00485	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TL13_RS00490	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TL13_RS00495	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TL13_RS00500	COG1841	ribosomal large subunit assembly
TL13_RS00510	COG0201	protein transport
TL13_RS00515	COG0563	adenylate kinase activity
TL13_RS00520	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TL13_RS00525	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TL13_RS00530	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TL13_RS00540	COG0202	RNA polymerase activity
TL13_RS00645	COG0582	viral genome integration into host DNA
TL13_RS00655	COG2946	Replication initiation factor
TL13_RS00670	COG1196	nuclear chromosome segregation
TL13_RS00670	COG1674	ftsk spoiiie
TL13_RS00700	COG1121	(ABC) transporter
TL13_RS00705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TL13_RS00710	COG0803	Belongs to the bacterial solute-binding protein 9 family
TL13_RS00710	COG3443	Belongs to the bacterial solute-binding protein 9 family
TL13_RS00755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TL13_RS00760	COG0085	RNA polymerase activity
TL13_RS00765	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TL13_RS00775	COG1619	proteins homologs of microcin C7 resistance protein MccF
TL13_RS00780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TL13_RS00785	COG1459	type II secretion system
TL13_RS00790	COG4537	Required for transformation and DNA binding
TL13_RS00900	COG0582	viral genome integration into host DNA
TL13_RS00910	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TL13_RS00920	COG0285	dihydrofolate synthase activity
TL13_RS00925	COG1363	Peptidase, m42
TL13_RS00935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TL13_RS00945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TL13_RS00965	COG0459	protein refolding
TL13_RS00975	COG0049	tRNA binding
TL13_RS00980	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TL13_RS01015	COG0126	phosphoglycerate kinase activity
TL13_RS01025	COG0789	Transcriptional regulator
TL13_RS01030	COG0174	glutamine synthetase
TL13_RS01045	COG1214	PFAM Peptidase M22, glycoprotease
TL13_RS01055	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TL13_RS01060	COG2207	Transcriptional regulator
TL13_RS01070	COG1175	transmembrane transport
TL13_RS01075	COG0395	ABC-type sugar transport system, permease component
TL13_RS01105	COG1131	(ABC) transporter
TL13_RS01115	COG2081	HI0933 family
TL13_RS01120	COG2723	6-phospho-beta-galactosidase activity
TL13_RS01135	COG0584	glycerophosphoryl diester phosphodiesterase
TL13_RS01145	COG2801	Transposase and inactivated derivatives
TL13_RS01150	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TL13_RS01155	COG2222	sugar isomerase
TL13_RS01185	COG2936	dipeptidyl-peptidase activity
TL13_RS01195	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TL13_RS01205	COG3942	CHAP domain
TL13_RS01210	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TL13_RS01240	COG1882	Formate acetyltransferase
TL13_RS01255	COG2910	NAD(P)H-binding
TL13_RS01270	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TL13_RS01275	COG0681	Belongs to the peptidase S26 family
TL13_RS01305	COG0366	Alpha amylase catalytic
TL13_RS01310	COG1263	PTS System
TL13_RS01310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TL13_RS01315	COG2188	Transcriptional regulator
TL13_RS01330	COG1193	negative regulation of DNA recombination
TL13_RS01340	COG3118	belongs to the thioredoxin family
TL13_RS01350	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TL13_RS01350	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TL13_RS01375	COG1115	amino acid carrier protein
TL13_RS01380	COG0668	transmembrane transport
TL13_RS01395	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TL13_RS01405	COG0167	dihydroorotate dehydrogenase activity
TL13_RS01410	COG2843	Capsule synthesis protein
TL13_RS01415	COG0561	phosphatase activity
TL13_RS01430	COG4555	ABC transporter
TL13_RS01435	COG1309	transcriptional regulator
TL13_RS01440	COG1511	domain protein
TL13_RS01475	COG2801	Transposase and inactivated derivatives
TL13_RS01485	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
TL13_RS01490	COG0433	COG0433 Predicted ATPase
TL13_RS01515	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TL13_RS01520	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TL13_RS01530	COG0124	histidyl-tRNA synthetase
TL13_RS01535	COG1064	alcohol dehydrogenase
TL13_RS01540	COG1454	alcohol dehydrogenase
TL13_RS01540	COG1012	belongs to the aldehyde dehydrogenase family
TL13_RS01550	COG4988	ABC transporter
TL13_RS01555	COG1132	(ABC) transporter
TL13_RS01570	COG1129	ABC transporter
TL13_RS01575	COG0534	Mate efflux family protein
TL13_RS01580	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TL13_RS01595	COG1304	FMN binding
TL13_RS01600	COG1132	(ABC) transporter
TL13_RS01605	COG1132	(ABC) transporter
TL13_RS01610	COG3830	Belongs to the UPF0237 family
TL13_RS01615	COG2848	UPF0210 protein
TL13_RS01620	COG0588	phosphoglycerate mutase activity
TL13_RS01635	COG1420	regulation of RNA biosynthetic process
TL13_RS01640	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TL13_RS01645	COG0443	Heat shock 70 kDa protein
TL13_RS01650	COG0484	heat shock protein binding
TL13_RS01655	COG0095	Lipoate-protein ligase
TL13_RS01665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TL13_RS01695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TL13_RS01700	COG0765	amino acid transport
TL13_RS01715	COG3655	Transcriptional regulator
TL13_RS01725	COG2217	Heavy metal translocating P-type atpase
TL13_RS01740	COG0351	phosphomethylpyrimidine kinase
TL13_RS01750	COG4475	Protein of unknown function (DUF436)
TL13_RS01780	COG1028	Short-chain dehydrogenase reductase Sdr
TL13_RS01785	COG2801	Transposase and inactivated derivatives
TL13_RS01790	COG2801	Transposase and inactivated derivatives
TL13_RS01805	COG0446	pyridine nucleotide-disulphide oxidoreductase
TL13_RS01805	COG1902	pentaerythritol trinitrate reductase activity
TL13_RS01820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TL13_RS01825	COG1309	transcriptional regulator
TL13_RS01840	COG0544	peptidyl-prolyl cis-trans isomerase activity
TL13_RS01860	COG3343	RNA polymerase activity
TL13_RS01865	COG0504	CTP synthase activity
TL13_RS01875	COG0191	fructose-bisphosphate aldolase activity
TL13_RS01880	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TL13_RS01920	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TL13_RS01940	COG0589	response to stress
TL13_RS01945	COG0436	Aminotransferase
TL13_RS01950	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
TL13_RS01955	COG1335	isochorismatase
TL13_RS01960	COG0335	large ribosomal subunit rRNA binding
TL13_RS01970	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TL13_RS01975	COG0154	amidase activity
TL13_RS01980	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TL13_RS01985	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TL13_RS01990	COG1609	Transcriptional regulator
TL13_RS01995	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TL13_RS02000	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
TL13_RS02015	COG3142	Participates in the control of copper homeostasis
TL13_RS02030	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
TL13_RS02035	COG1534	Rna-binding protein
TL13_RS02040	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TL13_RS02045	COG1713	HD superfamily hydrolase involved in NAD metabolism
TL13_RS02055	COG1335	isochorismatase
TL13_RS02060	COG0799	negative regulation of ribosome biogenesis
TL13_RS02065	COG2226	methyltransferase
TL13_RS02075	COG0789	Transcriptional regulator
TL13_RS02080	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
TL13_RS02100	COG0242	peptide deformylase activity
TL13_RS02110	COG1640	4-alpha-glucanotransferase
TL13_RS02115	COG0058	SHG alpha-glucan phosphorylase activity
TL13_RS02130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TL13_RS02130	COG1263	PTS System
TL13_RS02130	COG2190	(PTS) system
TL13_RS02145	COG0217	transcriptional regulatory protein
TL13_RS02160	COG4720	Psort location CytoplasmicMembrane, score
TL13_RS02170	COG1054	Belongs to the UPF0176 family
TL13_RS02180	COG1122	ATPase activity
TL13_RS02195	COG0357	Ribosomal RNA small subunit methyltransferase G
TL13_RS02200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TL13_RS02205	COG3331	DNA recombination
TL13_RS02210	COG4474	Belongs to the UPF0398 family
TL13_RS02215	COG3599	regulation of cell shape
TL13_RS02220	COG0116	Belongs to the methyltransferase superfamily
TL13_RS02230	COG1854	S-ribosylhomocysteine lyase activity
TL13_RS02235	COG1418	mRNA catabolic process
TL13_RS02245	COG1758	RNA polymerase activity
TL13_RS02250	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TL13_RS02255	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TL13_RS02260	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TL13_RS02260	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TL13_RS02265	COG0631	protein serine/threonine phosphatase activity
TL13_RS02270	COG2815	serine threonine protein kinase
TL13_RS02270	COG0515	serine threonine protein kinase
TL13_RS02295	COG1098	S1 RNA binding domain
TL13_RS02305	COG1739	Uncharacterized protein family UPF0029
TL13_RS02310	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
TL13_RS02395	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TL13_RS02405	COG3557	Belongs to the UPF0374 family
TL13_RS02415	COG2188	Transcriptional regulator
TL13_RS02420	COG2188	Transcriptional regulator
TL13_RS02430	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TL13_RS02440	COG3716	PTS system mannose fructose sorbose family IID component
TL13_RS02450	COG2017	converts alpha-aldose to the beta-anomer
TL13_RS02465	COG0346	lactoylglutathione lyase activity
TL13_RS02505	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TL13_RS02535	COG1217	gtp-binding protein TYPA
TL13_RS02550	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TL13_RS02565	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TL13_RS02570	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TL13_RS02575	COG1799	cell septum assembly
TL13_RS02590	COG3599	regulation of cell shape
TL13_RS02610	COG0494	nUDIX hydrolase
TL13_RS02610	COG0406	alpha-ribazole phosphatase activity
TL13_RS02615	COG0542	response to heat
TL13_RS02620	COG4703	Protein of unknown function (DUF1797)
TL13_RS02625	COG0765	amino acid transport
TL13_RS02630	COG1126	abc transporter atp-binding protein
TL13_RS02635	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TL13_RS02675	COG0789	Transcriptional regulator
TL13_RS02690	COG0826	peptidase U32
TL13_RS02700	COG4443	Transcriptional Coactivator p15 (PC4)
TL13_RS02705	COG1268	BioY protein
TL13_RS02710	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TL13_RS02715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TL13_RS02720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TL13_RS02725	COG1136	(ABC) transporter
TL13_RS02730	COG0577	efflux transmembrane transporter activity
TL13_RS02745	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TL13_RS02755	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TL13_RS02765	COG3859	Proton-coupled thiamine transporter YuaJ
TL13_RS02785	COG0772	Belongs to the SEDS family
TL13_RS02790	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TL13_RS02810	COG0149	triose-phosphate isomerase activity
TL13_RS02825	COG1078	dGTPase activity
TL13_RS02860	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TL13_RS02870	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TL13_RS02875	COG2884	Cell division ATP-binding protein ftsE
TL13_RS02880	COG2177	Part of the ABC transporter FtsEX involved in
TL13_RS02900	COG1132	(ABC) transporter
TL13_RS02905	COG1132	(ABC) transporter
TL13_RS02910	COG1011	Hydrolase
TL13_RS02930	COG1737	Transcriptional regulator
TL13_RS02940	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TL13_RS02945	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TL13_RS02950	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TL13_RS02960	COG2814	Major facilitator Superfamily
TL13_RS02965	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TL13_RS02975	COG0557	exoribonuclease II activity
TL13_RS02980	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TL13_RS02995	COG1674	ftsk spoiiie
TL13_RS03005	COG2946	Replication initiation factor
TL13_RS03035	COG0741	lytic transglycosylase activity
TL13_RS03035	COG0791	NLP P60 protein
TL13_RS03095	COG1129	ABC transporter
TL13_RS03100	COG1063	alcohol dehydrogenase
TL13_RS03115	COG2217	Heavy metal translocating P-type atpase
TL13_RS03120	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
TL13_RS03145	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TL13_RS03145	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TL13_RS03155	COG1832	CoA-binding protein
TL13_RS03165	COG0343	queuine tRNA-ribosyltransferase activity
TL13_RS03180	COG1609	Transcriptional regulator
TL13_RS03190	COG0438	transferase activity, transferring glycosyl groups
TL13_RS03205	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TL13_RS03210	COG0765	amino acid transport
TL13_RS03215	COG0765	amino acid transport
TL13_RS03220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TL13_RS03230	COG0745	RESPONSE REGULATOR receiver
TL13_RS03240	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TL13_RS03255	COG0488	(ABC) transporter
TL13_RS03260	COG0768	penicillin binding
TL13_RS03265	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TL13_RS03270	COG1181	Belongs to the D-alanine--D-alanine ligase family
TL13_RS03295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TL13_RS03305	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TL13_RS03315	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TL13_RS03335	COG1609	Transcriptional regulator
TL13_RS03340	COG4209	transmembrane transport
TL13_RS03345	COG0395	ABC-type sugar transport system, permease component
TL13_RS03350	COG1653	transport
TL13_RS03360	COG0697	spore germination
TL13_RS03360	COG1674	ftsk spoiiie
TL13_RS03365	COG0346	lactoylglutathione lyase activity
TL13_RS03390	COG0625	glutathione transferase activity
TL13_RS03395	COG2244	polysaccharide biosynthetic process
TL13_RS03400	COG0528	UMP kinase activity
TL13_RS03405	COG0233	cytoplasmic translational termination
TL13_RS03410	COG2996	Protein conserved in bacteria
TL13_RS03425	COG4479	Belongs to the UPF0346 family
TL13_RS03430	COG1702	phosphate starvation-inducible protein PhoH
TL13_RS03435	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TL13_RS03440	COG2807	transmembrane transport
TL13_RS03450	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TL13_RS03455	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TL13_RS03465	COG1234	tRNA 3'-trailer cleavage
TL13_RS03470	COG0300	oxidoreductase activity
TL13_RS03480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TL13_RS03485	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TL13_RS03485	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TL13_RS03495	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TL13_RS03510	COG2384	SAM-dependent methyltransferase
TL13_RS03515	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TL13_RS03525	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
TL13_RS03535	COG0135	phosphoribosylanthranilate isomerase activity
TL13_RS03540	COG1088	dTDP-glucose 4,6-dehydratase activity
TL13_RS03545	COG1091	dTDP-4-dehydrorhamnose reductase activity
TL13_RS03575	COG0463	Glycosyl transferase, family 2
TL13_RS03600	COG0463	Glycosyl transferase, family 2
TL13_RS03615	COG0438	transferase activity, transferring glycosyl groups
TL13_RS03640	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TL13_RS03650	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TL13_RS03665	COG1368	sulfuric ester hydrolase activity
TL13_RS03670	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TL13_RS03675	COG0710	3-dehydroquinate dehydratase activity
TL13_RS03680	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TL13_RS03685	COG0287	Prephenate dehydrogenase
TL13_RS03690	COG3679	Belongs to the UPF0342 family
TL13_RS03700	COG3684	Belongs to the aldolase LacD family
TL13_RS03720	COG4120	Belongs to the binding-protein-dependent transport system permease family
TL13_RS03735	COG2801	Transposase and inactivated derivatives
TL13_RS03740	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TL13_RS03745	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TL13_RS03750	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TL13_RS03755	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TL13_RS03765	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TL13_RS03765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TL13_RS03790	COG4122	O-methyltransferase activity
TL13_RS03795	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TL13_RS03805	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TL13_RS03825	COG1476	TRANSCRIPTIONal
TL13_RS03860	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TL13_RS03865	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TL13_RS03870	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
TL13_RS03875	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TL13_RS03880	COG0372	Belongs to the citrate synthase family
TL13_RS03885	COG0538	isocitrate dehydrogenase activity
TL13_RS03900	COG1012	belongs to the aldehyde dehydrogenase family
TL13_RS03930	COG1196	nuclear chromosome segregation
TL13_RS03935	COG0561	phosphatase activity
TL13_RS03940	COG0561	phosphatase activity
TL13_RS03945	COG0552	protein localization to endoplasmic reticulum
TL13_RS03960	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TL13_RS03965	COG3689	TIGRFAM TIGR03943 family protein
TL13_RS03970	COG0701	Predicted permease
TL13_RS03980	COG1597	lipid kinase activity
TL13_RS03990	COG0356	it plays a direct role in the translocation of protons across the membrane
TL13_RS03995	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TL13_RS04000	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TL13_RS04005	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TL13_RS04010	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TL13_RS04015	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TL13_RS04020	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TL13_RS04030	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TL13_RS04045	COG2211	Major facilitator Superfamily
TL13_RS04055	COG3250	beta-galactosidase activity
TL13_RS04065	COG0800	Aldolase
TL13_RS04075	COG1312	Catalyzes the dehydration of D-mannonate
TL13_RS04080	COG1028	Short-chain dehydrogenase reductase Sdr
TL13_RS04110	COG0072	phenylalanine-tRNA ligase activity
TL13_RS04110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TL13_RS04135	COG1051	belongs to the nudix hydrolase family
TL13_RS04140	COG0302	gtp cyclohydrolase
TL13_RS04160	COG2610	gluconate transmembrane transporter activity
TL13_RS04165	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TL13_RS04180	COG1846	Transcriptional regulator
TL13_RS04185	COG3759	membrane
TL13_RS04200	COG1695	Transcriptional regulator
TL13_RS04215	COG2195	Cleaves the N-terminal amino acid of tripeptides
TL13_RS04220	COG0561	phosphatase activity
TL13_RS04255	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TL13_RS04260	COG0196	riboflavin kinase activity
TL13_RS04265	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TL13_RS04270	COG1393	Belongs to the ArsC family
TL13_RS04275	COG4476	Belongs to the UPF0223 family
TL13_RS04280	COG0483	inositol monophosphate 1-phosphatase activity
TL13_RS04285	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TL13_RS04285	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TL13_RS04295	COG0573	inorganic phosphate transmembrane transporter activity
TL13_RS04300	COG0581	inorganic phosphate transmembrane transporter activity
TL13_RS04305	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TL13_RS04310	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TL13_RS04315	COG0704	Plays a role in the regulation of phosphate uptake
TL13_RS04325	COG0745	RESPONSE REGULATOR receiver
TL13_RS04330	COG5002	protein histidine kinase activity
TL13_RS04345	COG1072	(Pantothenic acid kinase))
TL13_RS04350	COG2813	Specifically methylates the guanine in position
TL13_RS04355	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
TL13_RS04365	COG0295	cytidine deaminase activity
TL13_RS04370	COG1744	ABC transporter substrate-binding protein PnrA-like
TL13_RS04375	COG3845	ABC transporter
TL13_RS04380	COG4603	Belongs to the binding-protein-dependent transport system permease family
TL13_RS04385	COG1079	Belongs to the binding-protein-dependent transport system permease family
TL13_RS04390	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
TL13_RS04395	COG0039	L-malate dehydrogenase activity
TL13_RS04400	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TL13_RS04405	COG3764	Sortase (surface protein transpeptidase)
TL13_RS04415	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TL13_RS04420	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TL13_RS04435	COG1104	cysteine desulfurase activity
TL13_RS04445	COG4116	CYTH
TL13_RS04450	COG2357	RelA SpoT domain protein
TL13_RS04455	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TL13_RS04460	COG0564	pseudouridine synthase activity
TL13_RS04465	COG0280	phosphate acetyltransferase
TL13_RS04470	COG1132	(ABC) transporter
TL13_RS04475	COG1132	(ABC) transporter
TL13_RS04485	COG1194	a g-specific adenine glycosylase
TL13_RS04490	COG1396	sequence-specific DNA binding
TL13_RS04510	COG2873	o-acetylhomoserine
TL13_RS04515	COG0488	(ABC) transporter
TL13_RS04525	COG1126	abc transporter atp-binding protein
TL13_RS04575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TL13_RS04580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TL13_RS04590	COG0297	glycogen (starch) synthase activity
TL13_RS04615	COG0167	dihydroorotate dehydrogenase activity
TL13_RS04620	COG0284	orotidine-5'-phosphate decarboxylase activity
TL13_RS04625	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TL13_RS04635	COG0463	Glycosyl transferase, family 2
TL13_RS04640	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
TL13_RS04650	COG0737	Belongs to the 5'-nucleotidase family
TL13_RS04665	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
TL13_RS04670	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TL13_RS04680	COG1272	protein, Hemolysin III
TL13_RS04690	COG0425	Belongs to the sulfur carrier protein TusA family
TL13_RS04690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TL13_RS04695	COG0110	maltose O-acetyltransferase activity
TL13_RS04700	COG0758	DNA mediated transformation
TL13_RS04705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TL13_RS04710	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TL13_RS04715	COG0222	ribosome binding
TL13_RS04720	COG0647	UMP catabolic process
TL13_RS04725	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TL13_RS04735	COG2382	esterase
TL13_RS04760	COG1136	(ABC) transporter
TL13_RS04765	COG0577	efflux transmembrane transporter activity
TL13_RS04780	COG0745	RESPONSE REGULATOR receiver
TL13_RS04795	COG4974	Belongs to the 'phage' integrase family
TL13_RS04820	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TL13_RS04825	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
TL13_RS04830	COG2188	Transcriptional regulator
TL13_RS04840	COG4268	DNA restriction-modification system
TL13_RS04845	COG1401	restriction endodeoxyribonuclease activity
TL13_RS04870	COG4221	oxidoreductase activity
TL13_RS04875	COG0741	lytic transglycosylase activity
TL13_RS04885	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TL13_RS04895	COG0009	L-threonylcarbamoyladenylate synthase
TL13_RS04900	COG2890	protein-(glutamine-N5) methyltransferase activity
TL13_RS04905	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TL13_RS04930	COG0481	GTPase activity
TL13_RS04945	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TL13_RS04955	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
TL13_RS04960	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
TL13_RS04975	COG1940	carbohydrate kinase activity
TL13_RS04985	COG0488	(ABC) transporter
TL13_RS04990	COG0617	tRNA 3'-terminal CCA addition
TL13_RS04995	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TL13_RS05000	COG1307	EDD domain protein, DegV family
TL13_RS05010	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TL13_RS05010	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TL13_RS05010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TL13_RS05015	COG1105	Belongs to the carbohydrate kinase PfkB family
TL13_RS05020	COG1349	DNA-binding transcription factor activity
TL13_RS05025	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TL13_RS05030	COG0336	Belongs to the RNA methyltransferase TrmD family
TL13_RS05035	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TL13_RS05040	COG0534	Mate efflux family protein
TL13_RS05050	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TL13_RS05055	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TL13_RS05070	COG2801	Transposase and inactivated derivatives
TL13_RS05080	COG1177	transmembrane transport
TL13_RS05085	COG1176	ABC-type spermidine putrescine transport system, permease component I
TL13_RS05090	COG3842	ATPase activity
TL13_RS05095	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TL13_RS05100	COG0083	homoserine kinase activity
TL13_RS05105	COG0460	homoserine dehydrogenase
TL13_RS05110	COG0726	polysaccharide deacetylase
TL13_RS05115	COG1132	(ABC) transporter
TL13_RS05130	COG0228	four-way junction DNA binding
TL13_RS05140	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TL13_RS05145	COG2521	methyltransferase
TL13_RS05145	COG2136	Putative SAM-dependent methyltransferase
TL13_RS05155	COG0505	Belongs to the CarA family
TL13_RS05160	COG0540	Belongs to the ATCase OTCase family
TL13_RS05165	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TL13_RS05175	COG2824	Alkylphosphonate utilization operon protein PhnA
TL13_RS05180	COG0564	pseudouridine synthase activity
TL13_RS05200	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TL13_RS05205	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TL13_RS05210	COG1114	Component of the transport system for branched-chain amino acids
TL13_RS05215	COG0301	tRNA thio-modification
TL13_RS05220	COG1104	cysteine desulfurase activity
TL13_RS05245	COG0539	negative regulation of cytoplasmic translation
TL13_RS05265	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TL13_RS05275	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TL13_RS05285	COG0187	DNA topoisomerase II activity
TL13_RS05295	COG1074	ATP-dependent DNA helicase activity
TL13_RS05300	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
TL13_RS05330	COG1131	(ABC) transporter
TL13_RS05360	COG1011	Hydrolase
TL13_RS05370	COG0210	DNA helicase
TL13_RS05385	COG1164	Oligoendopeptidase f
TL13_RS05395	COG0346	lactoylglutathione lyase activity
TL13_RS05400	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
TL13_RS05405	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TL13_RS05410	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TL13_RS05420	COG0446	pyridine nucleotide-disulphide oxidoreductase
TL13_RS05425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TL13_RS05430	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TL13_RS05450	COG1882	Formate acetyltransferase
TL13_RS05455	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TL13_RS05460	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TL13_RS05465	COG1447	Phosphotransferase system cellobiose-specific component IIA
TL13_RS05475	COG1349	DNA-binding transcription factor activity
TL13_RS05480	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TL13_RS05510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TL13_RS05520	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TL13_RS05530	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TL13_RS05535	COG4684	Psort location CytoplasmicMembrane, score
TL13_RS05540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TL13_RS05570	COG0531	amino acid
TL13_RS05580	COG0708	Exodeoxyribonuclease III
TL13_RS05590	COG1393	Belongs to the ArsC family
TL13_RS05595	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TL13_RS05600	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TL13_RS05610	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TL13_RS05620	COG4467	Involved in initiation control of chromosome replication
TL13_RS05625	COG0470	DNA polymerase III
TL13_RS05630	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TL13_RS05635	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TL13_RS05650	COG0517	IMP dehydrogenase activity
TL13_RS05655	COG2333	competence protein COMEC
TL13_RS05655	COG0658	competence protein
TL13_RS05660	COG1555	photosystem II stabilization
TL13_RS05660	COG1596	polysaccharide export
TL13_RS05665	COG0204	Acyl-transferase
TL13_RS05670	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TL13_RS05675	COG1120	ATPase activity
TL13_RS05680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TL13_RS05685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TL13_RS05690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TL13_RS05695	COG0386	Belongs to the glutathione peroxidase family
TL13_RS05700	COG1187	pseudouridine synthase activity
TL13_RS05705	COG0435	Glutathione S-transferase
TL13_RS05715	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
TL13_RS05720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TL13_RS05725	COG1696	Membrane protein involved in D-alanine export
TL13_RS05775	COG0363	glucosamine-6-phosphate deaminase activity
TL13_RS05785	COG1438	arginine binding
TL13_RS05790	COG3583	domain protein
TL13_RS05790	COG3525	Glycosyl hydrolase, family 20, catalytic domain
TL13_RS05790	COG3064	Membrane
TL13_RS05795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TL13_RS05800	COG1288	antiporter activity
TL13_RS05805	COG0549	Belongs to the carbamate kinase family
TL13_RS05810	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TL13_RS05815	COG0454	-acetyltransferase
TL13_RS05830	COG1481	regulation of sporulation
TL13_RS05835	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TL13_RS05840	COG1660	Displays ATPase and GTPase activities
TL13_RS05845	COG0251	oxidation-reduction process
TL13_RS05850	COG0534	Mate efflux family protein
TL13_RS05860	COG0436	Aminotransferase
TL13_RS05875	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TL13_RS05880	COG0562	UDP-galactopyranose mutase
TL13_RS05885	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TL13_RS05895	COG0077	Prephenate dehydratase
TL13_RS05900	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TL13_RS05925	COG1083	cytidylyl-transferase
TL13_RS05925	COG2755	lipolytic protein G-D-S-L family
TL13_RS05940	COG2089	acid synthase
TL13_RS05970	COG1216	Glycosyl transferase, family 2
TL13_RS05970	COG1442	glycosyl transferase family 8
TL13_RS05975	COG1215	transferase activity, transferring glycosyl groups
TL13_RS06010	COG4464	protein tyrosine phosphatase activity
TL13_RS06020	COG3944	biosynthesis protein
TL13_RS06025	COG1316	TRANSCRIPTIONal
TL13_RS06030	COG3022	response to hydroperoxide
TL13_RS06050	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TL13_RS06055	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TL13_RS06080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TL13_RS06085	COG1126	abc transporter atp-binding protein
TL13_RS06090	COG0765	amino acid transport
TL13_RS06095	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TL13_RS06105	COG0657	acetylesterase activity
TL13_RS06105	COG2755	lipolytic protein G-D-S-L family
TL13_RS06110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TL13_RS06120	COG0469	pyruvate kinase activity
TL13_RS06125	COG0205	6-phosphofructokinase activity
TL13_RS06135	COG2188	Transcriptional regulator
TL13_RS06140	COG1131	(ABC) transporter
TL13_RS06150	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
TL13_RS06185	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TL13_RS06190	COG1982	Orn Lys Arg decarboxylase major
TL13_RS06195	COG2151	metal-sulfur cluster biosynthetic enzyme
TL13_RS06200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TL13_RS06205	COG0358	DNA primase activity
TL13_RS06210	COG1970	mechanosensitive ion channel activity
TL13_RS06215	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TL13_RS06220	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TL13_RS06230	COG0647	UMP catabolic process
TL13_RS06235	COG1051	belongs to the nudix hydrolase family
TL13_RS06245	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TL13_RS06255	COG0058	SHG alpha-glucan phosphorylase activity
TL13_RS06260	COG0813	purine-nucleoside phosphorylase activity
TL13_RS06265	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TL13_RS06275	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TL13_RS06280	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TL13_RS06325	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TL13_RS06340	COG2268	Band 7 protein
TL13_RS06345	COG1704	LemA family
TL13_RS06355	COG1573	uracil-dna glycosylase
TL13_RS06380	COG2226	methyltransferase
TL13_RS06385	COG0488	(ABC) transporter
TL13_RS06390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TL13_RS06405	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TL13_RS06410	COG3442	glutamine amidotransferase
TL13_RS06415	COG2226	methyltransferase
TL13_RS06425	COG0488	(ABC) transporter
TL13_RS06460	COG3842	ATPase activity
TL13_RS06480	COG1263	PTS System
TL13_RS06480	COG2190	(PTS) system
TL13_RS06480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TL13_RS06485	COG3711	transcriptional antiterminator
TL13_RS06490	COG1293	RNA-binding protein homologous to eukaryotic snRNP
TL13_RS06495	COG3527	Alpha-acetolactate decarboxylase
TL13_RS06505	COG0628	permease
TL13_RS06510	COG2706	6-phosphogluconolactonase activity
TL13_RS06520	COG1011	Hydrolase
TL13_RS06610	COG2801	Transposase and inactivated derivatives
TL13_RS06645	COG0560	Phosphoserine phosphatase
TL13_RS06650	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
TL13_RS06655	COG0187	DNA topoisomerase II activity
TL13_RS06660	COG0693	protein deglycase activity
TL13_RS06665	COG0772	Belongs to the SEDS family
TL13_RS06680	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TL13_RS06685	COG0716	FMN binding
TL13_RS06695	COG0287	Prephenate dehydrogenase
TL13_RS06695	COG1605	Chorismate mutase
TL13_RS06700	COG0038	chloride channel
TL13_RS06710	COG0737	Belongs to the 5'-nucleotidase family
TL13_RS06715	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TL13_RS06720	COG1466	dna polymerase III delta subunit
TL13_RS06750	COG0559	Belongs to the binding-protein-dependent transport system permease family
TL13_RS06755	COG0683	leucine binding
TL13_RS06770	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TL13_RS06775	COG0366	Alpha amylase catalytic
TL13_RS06785	COG0395	ABC-type sugar transport system, permease component
TL13_RS06790	COG1175	transmembrane transport
TL13_RS06795	COG1653	transport
TL13_RS06805	COG2207	Transcriptional regulator
TL13_RS06810	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TL13_RS06815	COG0626	cystathionine gamma-synthase activity
TL13_RS06835	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
TL13_RS06840	COG2827	Endonuclease containing a URI domain
TL13_RS06860	COG0640	Transcriptional regulator
TL13_RS06865	COG0513	Belongs to the DEAD box helicase family
TL13_RS06870	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TL13_RS06910	COG0494	nUDIX hydrolase
TL13_RS06915	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TL13_RS06925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TL13_RS06930	COG1028	Short-chain dehydrogenase reductase Sdr
TL13_RS06955	COG0577	efflux transmembrane transporter activity
TL13_RS06960	COG1136	(ABC) transporter
TL13_RS06965	COG2205	protein histidine kinase activity
TL13_RS06980	COG0436	Aminotransferase
TL13_RS06990	COG1174	glycine betaine transport
TL13_RS06995	COG0517	IMP dehydrogenase activity
TL13_RS06995	COG1125	glycine betaine transport
TL13_RS07015	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TL13_RS07020	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TL13_RS07025	COG1482	cell wall glycoprotein biosynthetic process
TL13_RS07040	COG3091	SprT-like family
TL13_RS07045	COG2183	response to ionizing radiation
TL13_RS07050	COG0656	L-ascorbic acid biosynthetic process
TL13_RS07055	COG4708	membrane
TL13_RS07060	COG2246	polysaccharide biosynthetic process
TL13_RS07070	COG0024	Methionine aminopeptidase
TL13_RS07080	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TL13_RS07085	COG2249	NAD(P)H dehydrogenase (quinone) activity
TL13_RS07090	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TL13_RS07095	COG2131	deaminase
TL13_RS07105	COG1363	Peptidase, m42
TL13_RS07120	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TL13_RS07125	COG1956	GAF domain-containing protein
TL13_RS07135	COG1695	Transcriptional regulator
TL13_RS07145	COG0673	inositol 2-dehydrogenase activity
TL13_RS07150	COG0513	Belongs to the DEAD box helicase family
TL13_RS07155	COG0726	polysaccharide deacetylase
TL13_RS07170	COG0183	Belongs to the thiolase family
TL13_RS07175	COG3425	synthase
TL13_RS07190	COG0776	regulation of translation
TL13_RS07200	COG2755	lipolytic protein G-D-S-L family
TL13_RS07205	COG1307	EDD domain protein, DegV family
TL13_RS07210	COG0497	DNA recombination
TL13_RS07215	COG1438	arginine binding
TL13_RS07220	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
TL13_RS07230	COG1722	exodeoxyribonuclease VII activity
TL13_RS07235	COG1570	exodeoxyribonuclease VII activity
TL13_RS07240	COG2321	neutral zinc metallopeptidase
TL13_RS07245	COG1755	Isoprenylcysteine carboxyl methyltransferase
TL13_RS07250	COG5002	protein histidine kinase activity
TL13_RS07255	COG0745	RESPONSE REGULATOR receiver
TL13_RS07280	COG1227	inorganic diphosphatase activity
TL13_RS07300	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TL13_RS07315	COG2514	catechol 2,3-dioxygenase activity
TL13_RS07320	COG1472	Belongs to the glycosyl hydrolase 3 family
TL13_RS07325	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TL13_RS07330	COG2801	Transposase and inactivated derivatives
TL13_RS07340	COG1253	flavin adenine dinucleotide binding
TL13_RS07345	COG1119	ATPase activity
TL13_RS07350	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TL13_RS07360	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TL13_RS07365	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TL13_RS07370	COG0133	tryptophan synthase activity
TL13_RS07385	COG4470	Protein conserved in bacteria
TL13_RS07390	COG3480	Lon protease (S16) C-terminal proteolytic domain
TL13_RS07395	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TL13_RS07400	COG0742	ribosomal rna small subunit methyltransferase
TL13_RS07410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TL13_RS07415	COG4483	Protein conserved in bacteria
TL13_RS07420	COG2197	response regulator
TL13_RS07425	COG2203	Gaf domain
TL13_RS07425	COG4585	Histidine kinase
TL13_RS07430	COG0842	Transport permease protein
TL13_RS07435	COG1131	(ABC) transporter
TL13_RS07455	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TL13_RS07465	COG2755	lipolytic protein G-D-S-L family
TL13_RS07465	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TL13_RS07470	COG0671	phosphoesterase, PA-phosphatase related
TL13_RS07475	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
TL13_RS07490	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TL13_RS07495	COG1187	pseudouridine synthase activity
TL13_RS07500	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TL13_RS07505	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TL13_RS07510	COG0582	viral genome integration into host DNA
TL13_RS07530	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TL13_RS07535	COG3763	UPF0154 protein
TL13_RS07545	COG3579	cysteine-type endopeptidase activity
TL13_RS07560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TL13_RS07565	COG1254	Belongs to the acylphosphatase family
TL13_RS07575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TL13_RS07580	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TL13_RS07590	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TL13_RS07600	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TL13_RS07615	COG1160	GTP binding
TL13_RS07625	COG1484	DNA-dependent DNA replication
TL13_RS07635	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TL13_RS07640	COG0628	permease
TL13_RS07655	COG0745	RESPONSE REGULATOR receiver
TL13_RS07660	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TL13_RS07670	COG0492	ferredoxin-NADP+ reductase activity
TL13_RS07680	COG0513	Belongs to the DEAD box helicase family
TL13_RS07695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TL13_RS07700	COG0768	penicillin binding
TL13_RS07710	COG0275	rRNA processing
TL13_RS07760	COG4939	FMN-binding domain protein
TL13_RS07765	COG0142	geranyltranstransferase activity
TL13_RS07770	COG1252	NADH dehydrogenase
TL13_RS07785	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TL13_RS07790	COG0569	domain protein
TL13_RS07795	COG0534	Mate efflux family protein
TL13_RS07805	COG4224	UPF0291 protein
TL13_RS07810	COG0751	glycine-tRNA ligase activity
TL13_RS07840	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TL13_RS07845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TL13_RS07850	COG1464	Belongs to the NlpA lipoprotein family
TL13_RS07855	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TL13_RS07860	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TL13_RS07865	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TL13_RS07870	COG2252	PERMEase
TL13_RS07875	COG0561	phosphatase activity
TL13_RS07885	COG3715	PTS system
TL13_RS07890	COG3716	PTS system mannose fructose sorbose family IID component
TL13_RS07910	COG2801	Transposase and inactivated derivatives
TL13_RS07935	COG0439	Biotin carboxylase
TL13_RS07950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TL13_RS07955	COG1028	Short-chain dehydrogenase reductase Sdr
TL13_RS07960	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TL13_RS07965	COG2070	2-Nitropropane dioxygenase
TL13_RS07975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TL13_RS07985	COG1024	Enoyl-CoA hydratase
TL13_RS07990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TL13_RS07995	COG0527	aspartate kinase activity
TL13_RS08005	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TL13_RS08010	COG0736	holo-[acyl-carrier-protein] synthase activity
TL13_RS08015	COG0653	protein targeting
TL13_RS08025	COG1940	carbohydrate kinase activity
TL13_RS08030	COG2190	(PTS) system
TL13_RS08030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TL13_RS08030	COG1263	PTS System
TL13_RS08035	COG1621	beta-fructofuranosidase activity
TL13_RS08040	COG1609	Transcriptional regulator
TL13_RS08045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TL13_RS08060	COG0006	proline dipeptidase activity
TL13_RS08065	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TL13_RS08095	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TL13_RS08100	COG0629	single-stranded DNA binding
TL13_RS08110	COG0095	Lipoate-protein ligase
TL13_RS08125	COG0508	dehydrogenase complex catalyzes the overall conversion of
TL13_RS08130	COG0022	dehydrogenase e1 component
TL13_RS08130	COG0508	dehydrogenase complex catalyzes the overall conversion of
TL13_RS08135	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TL13_RS08140	COG2860	membrane
TL13_RS08155	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TL13_RS08160	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TL13_RS08170	COG2740	Nucleic-acid-binding protein implicated in transcription termination
TL13_RS08175	COG0195	Participates in both transcription termination and antitermination
TL13_RS08185	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TL13_RS08195	COG4473	ABC transporter
TL13_RS08200	COG1131	(ABC) transporter
TL13_RS08205	COG0537	adenosine 5'-monophosphoramidase activity
TL13_RS08215	COG1316	TRANSCRIPTIONal
TL13_RS08225	COG0802	atpase or kinase
TL13_RS08230	COG1461	Dihydroxyacetone kinase
TL13_RS08245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TL13_RS08250	COG0601	transmembrane transport
TL13_RS08255	COG4608	Belongs to the ABC transporter superfamily
TL13_RS08270	COG1686	Belongs to the peptidase S11 family
TL13_RS08285	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TL13_RS08290	COG0719	Fe-S assembly protein
TL13_RS08300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TL13_RS08305	COG4862	establishment of competence for transformation
TL13_RS08310	COG1968	undecaprenyl-diphosphatase activity
TL13_RS08315	COG0765	amino acid transport
TL13_RS08335	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TL13_RS08340	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TL13_RS08345	COG0440	acetolactate synthase activity
TL13_RS08350	COG0028	Belongs to the TPP enzyme family
TL13_RS08355	COG0463	Glycosyl transferase, family 2
TL13_RS08370	COG0129	dihydroxy-acid dehydratase activity
TL13_RS08380	COG2151	metal-sulfur cluster biosynthetic enzyme
TL13_RS08410	COG1674	ftsk spoiiie
TL13_RS08515	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TL13_RS08530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TL13_RS08555	COG3842	ATPase activity
TL13_RS08565	COG4753	response regulator
TL13_RS08565	COG2207	Transcriptional regulator
TL13_RS08570	COG2972	Histidine kinase
TL13_RS08580	COG1653	transport
TL13_RS08585	COG0395	ABC-type sugar transport system, permease component
TL13_RS08590	COG1175	transmembrane transport
TL13_RS08605	COG0383	alpha-mannosidase activity
TL13_RS08625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
TL13_RS08645	COG1045	serine acetyltransferase
TL13_RS08650	COG1185	polyribonucleotide nucleotidyltransferase activity
TL13_RS08655	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TL13_RS08690	COG0464	growth
TL13_RS08710	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TL13_RS08715	COG1187	pseudouridine synthase activity
TL13_RS08730	COG0242	peptide deformylase activity
TL13_RS08740	COG0066	3-isopropylmalate dehydratase activity
TL13_RS08745	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TL13_RS08770	COG2309	aminopeptidase activity
TL13_RS08780	COG2176	DNA-directed DNA polymerase activity
TL13_RS08795	COG2376	Dihydroxyacetone kinase
TL13_RS08805	COG2376	Dihydroxyacetone kinase
TL13_RS08810	COG1461	Dihydroxyacetone kinase
TL13_RS08815	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
TL13_RS08820	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
TL13_RS08825	COG0442	prolyl-tRNA aminoacylation
TL13_RS08835	COG4589	Belongs to the CDS family
TL13_RS08840	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TL13_RS08845	COG1862	Preprotein translocase
TL13_RS08855	COG1181	Belongs to the D-alanine--D-alanine ligase family
TL13_RS08855	COG2918	glutathione biosynthetic process
TL13_RS08865	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TL13_RS08870	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TL13_RS08875	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TL13_RS08880	COG0542	response to heat
TL13_RS08885	COG4463	regulation of RNA biosynthetic process
TL13_RS08900	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TL13_RS08930	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TL13_RS08935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TL13_RS08940	COG0492	ferredoxin-NADP+ reductase activity
TL13_RS08945	COG0564	pseudouridine synthase activity
TL13_RS08985	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TL13_RS09005	COG1564	THIamine pyrophosphokinase
TL13_RS09015	COG1162	GTPase activity
TL13_RS09050	COG4115	mRNA cleavage
TL13_RS09075	COG0084	hydrolase, TatD family'
TL13_RS09085	COG1847	R3H domain protein
TL13_RS09095	COG0594	ribonuclease P activity
TL13_RS09100	COG0165	Argininosuccinate lyase
TL13_RS09105	COG0137	argininosuccinate synthase activity
TL13_RS09115	COG1827	regulation of RNA biosynthetic process
TL13_RS09130	COG2040	homocysteine
TL13_RS09135	COG0833	amino acid
TL13_RS09170	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TL13_RS09180	COG0756	dUTP diphosphatase activity
TL13_RS09185	COG2832	Protein of unknown function (DUF454)
TL13_RS09195	COG0431	NADPH-dependent FMN reductase
TL13_RS09195	COG1053	succinate dehydrogenase
TL13_RS09195	COG3976	FMN-binding domain protein
TL13_RS09205	COG1132	(ABC) transporter
TL13_RS09210	COG1132	(ABC) transporter
TL13_RS09220	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TL13_RS09225	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TL13_RS09230	COG0705	Rhomboid family
TL13_RS09235	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TL13_RS09240	COG1473	amidohydrolase
TL13_RS09245	COG2171	N-acyltransferase activity
TL13_RS09260	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TL13_RS09280	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TL13_RS09305	COG3623	hexulose-6-phosphate isomerase
TL13_RS09330	COG1523	belongs to the glycosyl hydrolase 13 family
TL13_RS09345	COG0463	Glycosyl transferase, family 2
TL13_RS09365	COG1609	Transcriptional regulator
TL13_RS09370	COG1126	abc transporter atp-binding protein
TL13_RS09375	COG0765	amino acid transport
TL13_RS09380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TL13_RS09390	COG2801	Transposase and inactivated derivatives
TL13_RS09400	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TL13_RS09410	COG1447	Phosphotransferase system cellobiose-specific component IIA
TL13_RS09420	COG3711	transcriptional antiterminator
TL13_RS09420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TL13_RS09430	COG2723	6-phospho-beta-galactosidase activity
TL13_RS09435	COG1486	melibiose metabolic process
TL13_RS09445	COG4667	esterase of the alpha-beta hydrolase superfamily
TL13_RS09450	COG3590	peptidase
TL13_RS09455	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TL13_RS09460	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TL13_RS09460	COG1321	iron dependent repressor
TL13_RS09465	COG1121	(ABC) transporter
TL13_RS09480	COG0803	Belongs to the bacterial solute-binding protein 9 family
TL13_RS09500	COG2801	Transposase and inactivated derivatives
TL13_RS09510	COG1490	D-aminoacyl-tRNA deacylase activity
TL13_RS09520	COG0737	Belongs to the 5'-nucleotidase family
TL13_RS09535	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TL13_RS09555	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TL13_RS09580	COG0737	Belongs to the 5'-nucleotidase family
TL13_RS09595	COG1126	abc transporter atp-binding protein
TL13_RS09620	COG1438	arginine binding
TL13_RS09625	COG0018	arginyl-trna synthetase
TL13_RS09645	COG1640	4-alpha-glucanotransferase
TL13_RS09650	COG2182	Extracellular solute-binding protein
TL13_RS09655	COG1175	transmembrane transport
TL13_RS09660	COG3833	ABC-type maltose transport systems, permease component
TL13_RS09665	COG5521	maltodextrose utilization protein MalA
TL13_RS09670	COG1609	Transcriptional regulator
TL13_RS09675	COG1523	belongs to the glycosyl hydrolase 13 family
TL13_RS09680	COG1780	Probably involved in ribonucleotide reductase function
TL13_RS09685	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TL13_RS09690	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TL13_RS09695	COG2153	protein acetylation
TL13_RS09700	COG4989	oxidoreductase activity
TL13_RS09705	COG1216	Glycosyl transferase, family 2
TL13_RS09725	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TL13_RS09740	COG0305	Participates in initiation and elongation during chromosome replication
TL13_RS09745	COG0359	binds to the 23S rRNA
TL13_RS09755	COG0445	tRNA wobble uridine modification
TL13_RS09760	COG0494	nUDIX hydrolase
TL13_RS09770	COG1733	regulation of RNA biosynthetic process
TL13_RS09780	COG0482	sulfurtransferase activity
TL13_RS09785	COG1760	l-serine dehydratase
TL13_RS09790	COG1760	l-serine dehydratase
TL13_RS09805	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TL13_RS09810	COG1122	ATPase activity
TL13_RS09815	COG1122	ATPase activity
TL13_RS09820	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TL13_RS09825	COG1426	Protein conserved in bacteria
TL13_RS09830	COG0612	Peptidase, M16
TL13_RS09835	COG0612	Peptidase, M16
TL13_RS09925	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TL13_RS09930	COG0517	IMP dehydrogenase activity
TL13_RS09930	COG0516	GMP reductase activity
TL13_RS09940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TL13_RS09945	COG0488	(ABC) transporter
TL13_RS10025	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TL13_RS10030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TL13_RS10035	COG1475	DNA binding