locus-tag	class	description
K6968_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K6968_RS00010	COG0592	DNA-directed DNA polymerase activity
K6968_RS00030	COG0012	GTP binding
K6968_RS00035	COG0193	aminoacyl-tRNA hydrolase activity
K6968_RS00040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K6968_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K6968_RS00060	COG0037	tRNA processing
K6968_RS00070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K6968_RS00180	COG1792	Involved in formation and maintenance of cell shape
K6968_RS00195	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K6968_RS00200	COG0436	Aminotransferase
K6968_RS00205	COG1381	Involved in DNA repair and RecF pathway recombination
K6968_RS00210	COG0416	fatty acid biosynthetic process
K6968_RS00215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6968_RS00225	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K6968_RS00240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K6968_RS00245	COG0138	bifunctional purine biosynthesis protein purh
K6968_RS00250	COG0151	Belongs to the GarS family
K6968_RS00255	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K6968_RS00295	COG1131	(ABC) transporter
K6968_RS00305	COG1132	(ABC) transporter
K6968_RS00315	COG2255	four-way junction helicase activity
K6968_RS00325	COG0546	phosphoglycolate phosphatase activity
K6968_RS00345	COG0285	dihydrofolate synthase activity
K6968_RS00355	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K6968_RS00360	COG0632	four-way junction helicase activity
K6968_RS00365	COG0519	Catalyzes the synthesis of GMP from XMP
K6968_RS00380	COG1393	Belongs to the ArsC family
K6968_RS00385	COG4472	Bacterial protein of unknown function (DUF965)
K6968_RS00390	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K6968_RS00395	COG3906	Belongs to the UPF0473 family
K6968_RS00415	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K6968_RS00420	COG0088	Forms part of the polypeptide exit tunnel
K6968_RS00425	COG0089	rRNA binding
K6968_RS00430	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K6968_RS00435	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K6968_RS00440	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K6968_RS00445	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K6968_RS00450	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K6968_RS00455	COG0255	Belongs to the universal ribosomal protein uL29 family
K6968_RS00460	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K6968_RS00465	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K6968_RS00470	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K6968_RS00475	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K6968_RS00480	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K6968_RS00485	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K6968_RS00490	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K6968_RS00495	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K6968_RS00500	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K6968_RS00505	COG1841	ribosomal large subunit assembly
K6968_RS00515	COG0201	protein transport
K6968_RS00520	COG0563	adenylate kinase activity
K6968_RS00525	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K6968_RS00530	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K6968_RS00535	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K6968_RS00545	COG0202	RNA polymerase activity
K6968_RS00635	COG0582	viral genome integration into host DNA
K6968_RS00645	COG2946	Replication initiation factor
K6968_RS00680	COG0582	viral genome integration into host DNA
K6968_RS00695	COG1121	(ABC) transporter
K6968_RS00700	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K6968_RS00705	COG0803	Belongs to the bacterial solute-binding protein 9 family
K6968_RS00705	COG3443	Belongs to the bacterial solute-binding protein 9 family
K6968_RS00730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6968_RS00735	COG0085	RNA polymerase activity
K6968_RS00740	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K6968_RS00755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K6968_RS00760	COG1459	type II secretion system
K6968_RS00765	COG4537	Required for transformation and DNA binding
K6968_RS00795	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K6968_RS00805	COG0285	dihydrofolate synthase activity
K6968_RS00810	COG1363	Peptidase, m42
K6968_RS00820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6968_RS00830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6968_RS00855	COG0459	protein refolding
K6968_RS00865	COG0049	tRNA binding
K6968_RS00870	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K6968_RS00875	COG3590	peptidase
K6968_RS00885	COG0126	phosphoglycerate kinase activity
K6968_RS00895	COG0789	Transcriptional regulator
K6968_RS00900	COG0174	glutamine synthetase
K6968_RS00915	COG1214	PFAM Peptidase M22, glycoprotease
K6968_RS00925	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K6968_RS00930	COG2207	Transcriptional regulator
K6968_RS00940	COG1175	transmembrane transport
K6968_RS00945	COG0395	ABC-type sugar transport system, permease component
K6968_RS00965	COG2855	membrane
K6968_RS00990	COG1131	(ABC) transporter
K6968_RS00995	COG2081	HI0933 family
K6968_RS01000	COG2723	6-phospho-beta-galactosidase activity
K6968_RS01010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6968_RS01025	COG3959	Transketolase, thiamine diphosphate binding domain
K6968_RS01030	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K6968_RS01035	COG0584	glycerophosphoryl diester phosphodiesterase
K6968_RS01040	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K6968_RS01045	COG2222	sugar isomerase
K6968_RS01070	COG1882	Formate acetyltransferase
K6968_RS01085	COG2910	NAD(P)H-binding
K6968_RS01105	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K6968_RS01140	COG0363	glucosamine-6-phosphate deaminase activity
K6968_RS01155	COG2217	Heavy metal translocating P-type atpase
K6968_RS01160	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K6968_RS01165	COG0681	Belongs to the peptidase S26 family
K6968_RS01185	COG0366	Alpha amylase catalytic
K6968_RS01190	COG1263	PTS System
K6968_RS01190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6968_RS01195	COG2188	Transcriptional regulator
K6968_RS01210	COG1193	negative regulation of DNA recombination
K6968_RS01220	COG3118	belongs to the thioredoxin family
K6968_RS01225	COG0318	PFAM AMP-dependent synthetase and ligase
K6968_RS01230	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6968_RS01230	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6968_RS01255	COG1115	amino acid carrier protein
K6968_RS01260	COG0668	transmembrane transport
K6968_RS01270	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K6968_RS01275	COG0167	dihydroorotate dehydrogenase activity
K6968_RS01280	COG2843	Capsule synthesis protein
K6968_RS01285	COG0561	phosphatase activity
K6968_RS01300	COG1131	(ABC) transporter
K6968_RS01305	COG1309	transcriptional regulator
K6968_RS01310	COG1511	domain protein
K6968_RS01335	COG1346	cytolysis
K6968_RS01340	COG2116	formate transmembrane transporter activity
K6968_RS01345	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K6968_RS01350	COG0433	COG0433 Predicted ATPase
K6968_RS01355	COG0494	nUDIX hydrolase
K6968_RS01375	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K6968_RS01380	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K6968_RS01385	COG0124	histidyl-tRNA synthetase
K6968_RS01390	COG1064	alcohol dehydrogenase
K6968_RS01395	COG1454	alcohol dehydrogenase
K6968_RS01395	COG1012	belongs to the aldehyde dehydrogenase family
K6968_RS01405	COG4988	ABC transporter
K6968_RS01410	COG1132	(ABC) transporter
K6968_RS01425	COG1129	ABC transporter
K6968_RS01430	COG0534	Mate efflux family protein
K6968_RS01435	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K6968_RS01450	COG1304	FMN binding
K6968_RS01455	COG1132	(ABC) transporter
K6968_RS01460	COG1132	(ABC) transporter
K6968_RS01465	COG3830	Belongs to the UPF0237 family
K6968_RS01470	COG2848	UPF0210 protein
K6968_RS01475	COG0588	phosphoglycerate mutase activity
K6968_RS01480	COG1420	regulation of RNA biosynthetic process
K6968_RS01485	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K6968_RS01490	COG0443	Heat shock 70 kDa protein
K6968_RS01495	COG0484	heat shock protein binding
K6968_RS01500	COG0095	Lipoate-protein ligase
K6968_RS01510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6968_RS01515	COG0765	amino acid transport
K6968_RS01520	COG3655	Transcriptional regulator
K6968_RS01530	COG2217	Heavy metal translocating P-type atpase
K6968_RS01555	COG4475	Protein of unknown function (DUF436)
K6968_RS01585	COG4221	oxidoreductase activity
K6968_RS01590	COG0446	pyridine nucleotide-disulphide oxidoreductase
K6968_RS01590	COG1902	pentaerythritol trinitrate reductase activity
K6968_RS01595	COG1959	2 iron, 2 sulfur cluster binding
K6968_RS01615	COG0544	peptidyl-prolyl cis-trans isomerase activity
K6968_RS01640	COG0504	CTP synthase activity
K6968_RS01650	COG0191	fructose-bisphosphate aldolase activity
K6968_RS01655	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K6968_RS01690	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K6968_RS01695	COG0252	asparaginase activity
K6968_RS01710	COG0589	response to stress
K6968_RS01715	COG0436	Aminotransferase
K6968_RS01720	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
K6968_RS01725	COG1335	isochorismatase
K6968_RS01730	COG0335	large ribosomal subunit rRNA binding
K6968_RS01740	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K6968_RS01745	COG0154	amidase activity
K6968_RS01750	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K6968_RS01755	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K6968_RS01760	COG1609	Transcriptional regulator
K6968_RS01765	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K6968_RS01770	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
K6968_RS01780	COG3142	Participates in the control of copper homeostasis
K6968_RS01795	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K6968_RS01800	COG1534	Rna-binding protein
K6968_RS01805	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K6968_RS01810	COG1713	HD superfamily hydrolase involved in NAD metabolism
K6968_RS01830	COG0799	negative regulation of ribosome biogenesis
K6968_RS01835	COG2226	methyltransferase
K6968_RS01840	COG5290	Psort location Cytoplasmic, score
K6968_RS01850	COG0789	Transcriptional regulator
K6968_RS01855	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
K6968_RS01875	COG0242	peptide deformylase activity
K6968_RS01885	COG1640	4-alpha-glucanotransferase
K6968_RS01890	COG0058	SHG alpha-glucan phosphorylase activity
K6968_RS01905	COG1263	PTS System
K6968_RS01905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6968_RS01905	COG2190	(PTS) system
K6968_RS01920	COG0217	transcriptional regulatory protein
K6968_RS01930	COG4720	Psort location CytoplasmicMembrane, score
K6968_RS01940	COG1054	Belongs to the UPF0176 family
K6968_RS01950	COG1122	ATPase activity
K6968_RS01970	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6968_RS01975	COG3331	DNA recombination
K6968_RS01980	COG4474	Belongs to the UPF0398 family
K6968_RS01985	COG3599	regulation of cell shape
K6968_RS01995	COG0116	Belongs to the methyltransferase superfamily
K6968_RS02005	COG1854	S-ribosylhomocysteine lyase activity
K6968_RS02010	COG1418	mRNA catabolic process
K6968_RS02020	COG1758	RNA polymerase activity
K6968_RS02025	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K6968_RS02030	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K6968_RS02035	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K6968_RS02035	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K6968_RS02040	COG0631	protein serine/threonine phosphatase activity
K6968_RS02045	COG2815	serine threonine protein kinase
K6968_RS02045	COG0515	serine threonine protein kinase
K6968_RS02070	COG1098	S1 RNA binding domain
K6968_RS02080	COG1739	Uncharacterized protein family UPF0029
K6968_RS02085	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
K6968_RS02170	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K6968_RS02175	COG2137	regulation of response to DNA damage stimulus
K6968_RS02180	COG3557	Belongs to the UPF0374 family
K6968_RS02190	COG2188	Transcriptional regulator
K6968_RS02195	COG2188	Transcriptional regulator
K6968_RS02205	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6968_RS02215	COG3716	PTS system mannose fructose sorbose family IID component
K6968_RS02225	COG2017	converts alpha-aldose to the beta-anomer
K6968_RS02240	COG0346	lactoylglutathione lyase activity
K6968_RS02290	COG1217	gtp-binding protein TYPA
K6968_RS02305	COG0681	Belongs to the peptidase S26 family
K6968_RS02340	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K6968_RS02355	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K6968_RS02360	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K6968_RS02365	COG1799	cell septum assembly
K6968_RS02380	COG3599	regulation of cell shape
K6968_RS02400	COG0406	alpha-ribazole phosphatase activity
K6968_RS02400	COG0494	nUDIX hydrolase
K6968_RS02405	COG0542	response to heat
K6968_RS02410	COG4703	Protein of unknown function (DUF1797)
K6968_RS02415	COG0765	amino acid transport
K6968_RS02425	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K6968_RS02455	COG0789	Transcriptional regulator
K6968_RS02470	COG0826	peptidase U32
K6968_RS02480	COG4443	Transcriptional Coactivator p15 (PC4)
K6968_RS02485	COG1268	BioY protein
K6968_RS02490	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
K6968_RS02495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6968_RS02500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6968_RS02505	COG1136	(ABC) transporter
K6968_RS02510	COG0577	efflux transmembrane transporter activity
K6968_RS02520	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K6968_RS02530	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K6968_RS02540	COG3859	Proton-coupled thiamine transporter YuaJ
K6968_RS02560	COG0772	Belongs to the SEDS family
K6968_RS02565	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K6968_RS02570	COG1595	DNA-templated transcription, initiation
K6968_RS02580	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K6968_RS02585	COG0149	triose-phosphate isomerase activity
K6968_RS02595	COG1078	dGTPase activity
K6968_RS02610	COG2826	transposase and inactivated derivatives, IS30 family
K6968_RS02615	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K6968_RS02625	COG1131	(ABC) transporter
K6968_RS02630	COG2188	Transcriptional regulator
K6968_RS02640	COG0205	6-phosphofructokinase activity
K6968_RS02645	COG0469	pyruvate kinase activity
K6968_RS02655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6968_RS02660	COG2755	lipolytic protein G-D-S-L family
K6968_RS02660	COG0657	acetylesterase activity
K6968_RS02670	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K6968_RS02675	COG0765	amino acid transport
K6968_RS02680	COG1126	abc transporter atp-binding protein
K6968_RS02685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6968_RS02700	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K6968_RS02705	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K6968_RS02710	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K6968_RS02725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6968_RS02730	COG3022	response to hydroperoxide
K6968_RS02740	COG3944	biosynthesis protein
K6968_RS02750	COG4464	protein tyrosine phosphatase activity
K6968_RS02765	COG0438	transferase activity, transferring glycosyl groups
K6968_RS02780	COG1442	glycosyl transferase family 8
K6968_RS02780	COG1216	Glycosyl transferase, family 2
K6968_RS02785	COG1442	glycosyl transferase family 8
K6968_RS02785	COG1216	Glycosyl transferase, family 2
K6968_RS02810	COG2089	acid synthase
K6968_RS02825	COG2755	lipolytic protein G-D-S-L family
K6968_RS02825	COG1083	cytidylyl-transferase
K6968_RS02900	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K6968_RS02905	COG0077	Prephenate dehydratase
K6968_RS02915	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K6968_RS02940	COG0488	(ABC) transporter
K6968_RS02975	COG2226	methyltransferase
K6968_RS03015	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6968_RS03015	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6968_RS03060	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K6968_RS03120	COG4695	Portal protein
K6968_RS03125	COG0740	serine-type endopeptidase activity
K6968_RS03195	COG0860	N-Acetylmuramoyl-L-alanine amidase
K6968_RS03195	COG1388	LysM domain
K6968_RS03230	COG2207	Transcriptional regulator
K6968_RS03230	COG3708	Transcriptional regulator
K6968_RS03245	COG0562	UDP-galactopyranose mutase
K6968_RS03250	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K6968_RS03270	COG0436	Aminotransferase
K6968_RS03290	COG0534	Mate efflux family protein
K6968_RS03295	COG0251	oxidation-reduction process
K6968_RS03300	COG1660	Displays ATPase and GTPase activities
K6968_RS03305	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K6968_RS03310	COG1481	regulation of sporulation
K6968_RS03325	COG0454	-acetyltransferase
K6968_RS03330	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K6968_RS03335	COG0549	Belongs to the carbamate kinase family
K6968_RS03340	COG1288	antiporter activity
K6968_RS03345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6968_RS03355	COG1438	arginine binding
K6968_RS03360	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K6968_RS03365	COG0363	glucosamine-6-phosphate deaminase activity
K6968_RS03400	COG1696	Membrane protein involved in D-alanine export
K6968_RS03405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6968_RS03410	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
K6968_RS03420	COG0435	Glutathione S-transferase
K6968_RS03425	COG1187	pseudouridine synthase activity
K6968_RS03430	COG0386	Belongs to the glutathione peroxidase family
K6968_RS03435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6968_RS03440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6968_RS03445	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K6968_RS03450	COG1120	ATPase activity
K6968_RS03455	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K6968_RS03460	COG0204	Acyl-transferase
K6968_RS03465	COG1555	photosystem II stabilization
K6968_RS03465	COG1596	polysaccharide export
K6968_RS03470	COG0658	competence protein
K6968_RS03470	COG2333	competence protein COMEC
K6968_RS03480	COG0517	IMP dehydrogenase activity
K6968_RS03495	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6968_RS03500	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K6968_RS03505	COG0470	DNA polymerase III
K6968_RS03510	COG4467	Involved in initiation control of chromosome replication
K6968_RS03520	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K6968_RS03530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K6968_RS03535	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K6968_RS03540	COG1393	Belongs to the ArsC family
K6968_RS03550	COG0708	Exodeoxyribonuclease III
K6968_RS03560	COG0531	amino acid
K6968_RS03620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6968_RS03625	COG4684	Psort location CytoplasmicMembrane, score
K6968_RS03630	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K6968_RS03640	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K6968_RS03650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6968_RS03655	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K6968_RS03665	COG0732	type I restriction modification DNA specificity domain
K6968_RS03700	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K6968_RS03705	COG1349	DNA-binding transcription factor activity
K6968_RS03715	COG1447	Phosphotransferase system cellobiose-specific component IIA
K6968_RS03720	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K6968_RS03725	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K6968_RS03730	COG1882	Formate acetyltransferase
K6968_RS03750	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K6968_RS03755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6968_RS03760	COG0446	pyridine nucleotide-disulphide oxidoreductase
K6968_RS03770	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K6968_RS03775	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K6968_RS03780	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K6968_RS03785	COG0346	lactoylglutathione lyase activity
K6968_RS03795	COG1164	Oligoendopeptidase f
K6968_RS03810	COG0210	DNA helicase
K6968_RS03825	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
K6968_RS03840	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
K6968_RS03855	COG1122	ATPase activity
K6968_RS03860	COG1122	ATPase activity
K6968_RS03865	COG1011	Hydrolase
K6968_RS03895	COG1131	(ABC) transporter
K6968_RS03925	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
K6968_RS03930	COG1074	ATP-dependent DNA helicase activity
K6968_RS03940	COG0187	DNA topoisomerase II activity
K6968_RS03965	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K6968_RS03975	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K6968_RS03995	COG0539	negative regulation of cytoplasmic translation
K6968_RS04020	COG1104	cysteine desulfurase activity
K6968_RS04025	COG0301	tRNA thio-modification
K6968_RS04030	COG1114	Component of the transport system for branched-chain amino acids
K6968_RS04035	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K6968_RS04040	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K6968_RS04060	COG0564	pseudouridine synthase activity
K6968_RS04065	COG2824	Alkylphosphonate utilization operon protein PhnA
K6968_RS04075	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
K6968_RS04080	COG0540	Belongs to the ATCase OTCase family
K6968_RS04085	COG0505	Belongs to the CarA family
K6968_RS04095	COG2521	methyltransferase
K6968_RS04095	COG2136	Putative SAM-dependent methyltransferase
K6968_RS04100	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
K6968_RS04110	COG0228	four-way junction DNA binding
K6968_RS04125	COG1132	(ABC) transporter
K6968_RS04130	COG0726	polysaccharide deacetylase
K6968_RS04135	COG0460	homoserine dehydrogenase
K6968_RS04140	COG0083	homoserine kinase activity
K6968_RS04145	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K6968_RS04150	COG3842	ATPase activity
K6968_RS04155	COG1176	ABC-type spermidine putrescine transport system, permease component I
K6968_RS04160	COG1177	transmembrane transport
K6968_RS04170	COG0038	chloride channel
K6968_RS04185	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K6968_RS04190	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K6968_RS04205	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K6968_RS04210	COG0336	Belongs to the RNA methyltransferase TrmD family
K6968_RS04215	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K6968_RS04220	COG1349	DNA-binding transcription factor activity
K6968_RS04225	COG1105	Belongs to the carbohydrate kinase PfkB family
K6968_RS04230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6968_RS04230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K6968_RS04230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K6968_RS04240	COG1307	EDD domain protein, DegV family
K6968_RS04245	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K6968_RS04250	COG0617	tRNA 3'-terminal CCA addition
K6968_RS04255	COG0488	(ABC) transporter
K6968_RS04265	COG1940	carbohydrate kinase activity
K6968_RS04280	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K6968_RS04285	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K6968_RS04290	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K6968_RS04310	COG0481	GTPase activity
K6968_RS04330	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K6968_RS04335	COG2890	protein-(glutamine-N5) methyltransferase activity
K6968_RS04340	COG0009	L-threonylcarbamoyladenylate synthase
K6968_RS04350	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K6968_RS04360	COG0741	lytic transglycosylase activity
K6968_RS04365	COG4221	oxidoreductase activity
K6968_RS04390	COG1401	restriction endodeoxyribonuclease activity
K6968_RS04395	COG4268	DNA restriction-modification system
K6968_RS04465	COG2188	Transcriptional regulator
K6968_RS04470	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
K6968_RS04475	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K6968_RS04490	COG1660	Displays ATPase and GTPase activities
K6968_RS04505	COG4974	Belongs to the 'phage' integrase family
K6968_RS04520	COG0745	RESPONSE REGULATOR receiver
K6968_RS04540	COG1136	(ABC) transporter
K6968_RS04580	COG2382	esterase
K6968_RS04590	COG3708	Transcriptional regulator
K6968_RS04590	COG2207	Transcriptional regulator
K6968_RS04595	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
K6968_RS04600	COG0647	UMP catabolic process
K6968_RS04605	COG0222	ribosome binding
K6968_RS04610	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K6968_RS04615	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K6968_RS04620	COG0758	DNA mediated transformation
K6968_RS04625	COG0110	maltose O-acetyltransferase activity
K6968_RS04630	COG1937	Protein conserved in bacteria
K6968_RS04640	COG0446	pyridine nucleotide-disulphide oxidoreductase
K6968_RS04650	COG1272	protein, Hemolysin III
K6968_RS04660	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K6968_RS04665	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K6968_RS04680	COG0737	Belongs to the 5'-nucleotidase family
K6968_RS04690	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K6968_RS04695	COG0463	Glycosyl transferase, family 2
K6968_RS04705	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K6968_RS04710	COG0284	orotidine-5'-phosphate decarboxylase activity
K6968_RS04715	COG0167	dihydroorotate dehydrogenase activity
K6968_RS04735	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K6968_RS04740	COG0297	glycogen (starch) synthase activity
K6968_RS04750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6968_RS04755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6968_RS04770	COG3583	domain protein
K6968_RS04795	COG1126	abc transporter atp-binding protein
K6968_RS04805	COG0488	(ABC) transporter
K6968_RS04810	COG2873	o-acetylhomoserine
K6968_RS04835	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K6968_RS04835	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K6968_RS04845	COG3711	transcriptional antiterminator
K6968_RS04850	COG3684	Belongs to the aldolase LacD family
K6968_RS04860	COG0698	ribose 5-phosphate isomerase
K6968_RS04865	COG0698	ribose 5-phosphate isomerase
K6968_RS04870	COG1349	DNA-binding transcription factor activity
K6968_RS04895	COG1396	sequence-specific DNA binding
K6968_RS04900	COG1194	a g-specific adenine glycosylase
K6968_RS04910	COG1132	(ABC) transporter
K6968_RS04915	COG1132	(ABC) transporter
K6968_RS04920	COG0280	phosphate acetyltransferase
K6968_RS04925	COG0564	pseudouridine synthase activity
K6968_RS04930	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K6968_RS04935	COG2357	RelA SpoT domain protein
K6968_RS04940	COG4116	CYTH
K6968_RS04950	COG1104	cysteine desulfurase activity
K6968_RS04965	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K6968_RS04970	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K6968_RS04980	COG3764	Sortase (surface protein transpeptidase)
K6968_RS04985	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K6968_RS04990	COG0039	L-malate dehydrogenase activity
K6968_RS05000	COG1079	Belongs to the binding-protein-dependent transport system permease family
K6968_RS05005	COG4603	Belongs to the binding-protein-dependent transport system permease family
K6968_RS05010	COG3845	ABC transporter
K6968_RS05015	COG1744	ABC transporter substrate-binding protein PnrA-like
K6968_RS05030	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K6968_RS05035	COG2813	Specifically methylates the guanine in position
K6968_RS05040	COG1072	(Pantothenic acid kinase))
K6968_RS05045	COG0268	Binds directly to 16S ribosomal RNA
K6968_RS05060	COG5002	protein histidine kinase activity
K6968_RS05065	COG0745	RESPONSE REGULATOR receiver
K6968_RS05080	COG0704	Plays a role in the regulation of phosphate uptake
K6968_RS05085	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K6968_RS05090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K6968_RS05095	COG0581	inorganic phosphate transmembrane transporter activity
K6968_RS05100	COG0573	inorganic phosphate transmembrane transporter activity
K6968_RS05110	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
K6968_RS05110	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K6968_RS05115	COG0483	inositol monophosphate 1-phosphatase activity
K6968_RS05120	COG4476	Belongs to the UPF0223 family
K6968_RS05125	COG1393	Belongs to the ArsC family
K6968_RS05130	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K6968_RS05135	COG0196	riboflavin kinase activity
K6968_RS05140	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K6968_RS05195	COG0561	phosphatase activity
K6968_RS05200	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6968_RS05235	COG3759	membrane
K6968_RS05240	COG1846	Transcriptional regulator
K6968_RS05255	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K6968_RS05260	COG2610	gluconate transmembrane transporter activity
K6968_RS05280	COG0302	gtp cyclohydrolase
K6968_RS05285	COG1051	belongs to the nudix hydrolase family
K6968_RS05310	COG0072	phenylalanine-tRNA ligase activity
K6968_RS05310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6968_RS05340	COG1028	Short-chain dehydrogenase reductase Sdr
K6968_RS05345	COG1312	Catalyzes the dehydration of D-mannonate
K6968_RS05355	COG0800	Aldolase
K6968_RS05365	COG3250	beta-galactosidase activity
K6968_RS05375	COG2211	Major facilitator Superfamily
K6968_RS05390	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K6968_RS05400	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K6968_RS05405	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K6968_RS05410	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K6968_RS05415	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K6968_RS05420	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K6968_RS05425	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K6968_RS05430	COG0356	it plays a direct role in the translocation of protons across the membrane
K6968_RS05440	COG1597	lipid kinase activity
K6968_RS05455	COG0701	Predicted permease
K6968_RS05460	COG3689	TIGRFAM TIGR03943 family protein
K6968_RS05465	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K6968_RS05480	COG0552	protein localization to endoplasmic reticulum
K6968_RS05485	COG0561	phosphatase activity
K6968_RS05490	COG0561	phosphatase activity
K6968_RS05495	COG1196	nuclear chromosome segregation
K6968_RS05520	COG2826	transposase and inactivated derivatives, IS30 family
K6968_RS05535	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6968_RS05540	COG0538	isocitrate dehydrogenase activity
K6968_RS05545	COG0372	Belongs to the citrate synthase family
K6968_RS05550	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K6968_RS05555	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K6968_RS05560	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K6968_RS05570	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K6968_RS05575	COG1609	Transcriptional regulator
K6968_RS05610	COG3716	PTS system mannose fructose sorbose family IID component
K6968_RS05620	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6968_RS05625	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6968_RS05650	COG1028	Short-chain dehydrogenase reductase Sdr
K6968_RS05685	COG1476	TRANSCRIPTIONal
K6968_RS05705	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K6968_RS05715	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6968_RS05720	COG4122	O-methyltransferase activity
K6968_RS05745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6968_RS05745	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6968_RS05755	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K6968_RS05760	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K6968_RS05765	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K6968_RS05770	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K6968_RS05775	COG1116	anion transmembrane transporter activity
K6968_RS05775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K6968_RS05780	COG4120	Belongs to the binding-protein-dependent transport system permease family
K6968_RS05795	COG3684	Belongs to the aldolase LacD family
K6968_RS05805	COG3679	Belongs to the UPF0342 family
K6968_RS05810	COG0287	Prephenate dehydrogenase
K6968_RS05815	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K6968_RS05820	COG0710	3-dehydroquinate dehydratase activity
K6968_RS05825	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K6968_RS05830	COG1368	sulfuric ester hydrolase activity
K6968_RS05845	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K6968_RS05855	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K6968_RS05885	COG1216	Glycosyl transferase, family 2
K6968_RS05900	COG1442	glycosyl transferase family 8
K6968_RS05900	COG1216	Glycosyl transferase, family 2
K6968_RS05905	COG1442	glycosyl transferase family 8
K6968_RS05935	COG0463	Glycosyl transferase, family 2
K6968_RS05965	COG1091	dTDP-4-dehydrorhamnose reductase activity
K6968_RS05970	COG1088	dTDP-glucose 4,6-dehydratase activity
K6968_RS05985	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K6968_RS05995	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K6968_RS06000	COG2384	SAM-dependent methyltransferase
K6968_RS06015	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K6968_RS06025	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K6968_RS06025	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
K6968_RS06030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6968_RS06040	COG0300	oxidoreductase activity
K6968_RS06045	COG1234	tRNA 3'-trailer cleavage
K6968_RS06055	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K6968_RS06060	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K6968_RS06070	COG2807	transmembrane transport
K6968_RS06075	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K6968_RS06080	COG1702	phosphate starvation-inducible protein PhoH
K6968_RS06085	COG4479	Belongs to the UPF0346 family
K6968_RS06100	COG2996	Protein conserved in bacteria
K6968_RS06105	COG0233	cytoplasmic translational termination
K6968_RS06110	COG0528	UMP kinase activity
K6968_RS06115	COG2244	polysaccharide biosynthetic process
K6968_RS06120	COG0625	glutathione transferase activity
K6968_RS06145	COG0346	lactoylglutathione lyase activity
K6968_RS06150	COG1674	ftsk spoiiie
K6968_RS06150	COG0697	spore germination
K6968_RS06155	COG1621	beta-fructofuranosidase activity
K6968_RS06165	COG0395	ABC-type sugar transport system, permease component
K6968_RS06170	COG4209	transmembrane transport
K6968_RS06175	COG1609	Transcriptional regulator
K6968_RS06195	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K6968_RS06210	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K6968_RS06220	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K6968_RS06230	COG1181	Belongs to the D-alanine--D-alanine ligase family
K6968_RS06235	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K6968_RS06240	COG0768	penicillin binding
K6968_RS06250	COG0488	(ABC) transporter
K6968_RS06255	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K6968_RS06265	COG0745	RESPONSE REGULATOR receiver
K6968_RS06270	COG1126	abc transporter atp-binding protein
K6968_RS06275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6968_RS06280	COG0765	amino acid transport
K6968_RS06285	COG0765	amino acid transport
K6968_RS06290	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K6968_RS06305	COG0438	transferase activity, transferring glycosyl groups
K6968_RS06320	COG1609	Transcriptional regulator
K6968_RS06330	COG0343	queuine tRNA-ribosyltransferase activity
K6968_RS06340	COG1832	CoA-binding protein
K6968_RS06350	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6968_RS06350	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6968_RS06365	COG1136	(ABC) transporter
K6968_RS06375	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
K6968_RS06380	COG2217	Heavy metal translocating P-type atpase
K6968_RS06395	COG1063	alcohol dehydrogenase
K6968_RS06400	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K6968_RS06405	COG0557	exoribonuclease II activity
K6968_RS06415	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K6968_RS06420	COG2814	Major facilitator Superfamily
K6968_RS06430	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K6968_RS06435	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K6968_RS06440	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K6968_RS06450	COG1737	Transcriptional regulator
K6968_RS06460	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
K6968_RS06470	COG1011	Hydrolase
K6968_RS06475	COG1132	(ABC) transporter
K6968_RS06480	COG1132	(ABC) transporter
K6968_RS06505	COG2177	Part of the ABC transporter FtsEX involved in
K6968_RS06510	COG2884	Cell division ATP-binding protein ftsE
K6968_RS06520	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K6968_RS06550	COG2826	transposase and inactivated derivatives, IS30 family
K6968_RS06585	COG2151	metal-sulfur cluster biosynthetic enzyme
K6968_RS06590	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K6968_RS06595	COG0358	DNA primase activity
K6968_RS06600	COG1970	mechanosensitive ion channel activity
K6968_RS06605	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K6968_RS06610	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K6968_RS06620	COG0647	UMP catabolic process
K6968_RS06625	COG1051	belongs to the nudix hydrolase family
K6968_RS06635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K6968_RS06645	COG0058	SHG alpha-glucan phosphorylase activity
K6968_RS06650	COG0813	purine-nucleoside phosphorylase activity
K6968_RS06655	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K6968_RS06665	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K6968_RS06670	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K6968_RS06675	COG0732	type I restriction modification DNA specificity domain
K6968_RS06695	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K6968_RS06710	COG2268	Band 7 protein
K6968_RS06715	COG1704	LemA family
K6968_RS06725	COG1573	uracil-dna glycosylase
K6968_RS06760	COG2226	methyltransferase
K6968_RS06765	COG0488	(ABC) transporter
K6968_RS06770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6968_RS06785	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K6968_RS06790	COG3442	glutamine amidotransferase
K6968_RS06795	COG2226	methyltransferase
K6968_RS06805	COG0488	(ABC) transporter
K6968_RS06840	COG3842	ATPase activity
K6968_RS06860	COG1263	PTS System
K6968_RS06860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6968_RS06860	COG2190	(PTS) system
K6968_RS06865	COG3711	transcriptional antiterminator
K6968_RS06870	COG1293	RNA-binding protein homologous to eukaryotic snRNP
K6968_RS06875	COG3527	Alpha-acetolactate decarboxylase
K6968_RS06885	COG0628	permease
K6968_RS06890	COG2706	6-phosphogluconolactonase activity
K6968_RS06900	COG1011	Hydrolase
K6968_RS06945	COG0560	Phosphoserine phosphatase
K6968_RS06950	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
K6968_RS06955	COG0187	DNA topoisomerase II activity
K6968_RS06960	COG0693	protein deglycase activity
K6968_RS06965	COG0772	Belongs to the SEDS family
K6968_RS06970	COG0582	viral genome integration into host DNA
K6968_RS07055	COG0582	viral genome integration into host DNA
K6968_RS07070	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K6968_RS07075	COG0716	FMN binding
K6968_RS07085	COG1605	Chorismate mutase
K6968_RS07085	COG0287	Prephenate dehydrogenase
K6968_RS07090	COG0038	chloride channel
K6968_RS07100	COG0737	Belongs to the 5'-nucleotidase family
K6968_RS07105	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K6968_RS07110	COG1466	dna polymerase III delta subunit
K6968_RS07145	COG0683	leucine binding
K6968_RS07160	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K6968_RS07165	COG0366	Alpha amylase catalytic
K6968_RS07175	COG0395	ABC-type sugar transport system, permease component
K6968_RS07180	COG1175	transmembrane transport
K6968_RS07185	COG1653	transport
K6968_RS07195	COG2207	Transcriptional regulator
K6968_RS07200	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K6968_RS07205	COG0626	cystathionine gamma-synthase activity
K6968_RS07225	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K6968_RS07230	COG2827	Endonuclease containing a URI domain
K6968_RS07255	COG0640	Transcriptional regulator
K6968_RS07260	COG0513	Belongs to the DEAD box helicase family
K6968_RS07265	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6968_RS07305	COG0494	nUDIX hydrolase
K6968_RS07310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K6968_RS07325	COG1028	Short-chain dehydrogenase reductase Sdr
K6968_RS07355	COG0577	efflux transmembrane transporter activity
K6968_RS07360	COG1136	(ABC) transporter
K6968_RS07365	COG2205	protein histidine kinase activity
K6968_RS07380	COG0436	Aminotransferase
K6968_RS07390	COG1174	glycine betaine transport
K6968_RS07395	COG1125	glycine betaine transport
K6968_RS07395	COG0517	IMP dehydrogenase activity
K6968_RS07415	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K6968_RS07420	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
K6968_RS07425	COG1482	cell wall glycoprotein biosynthetic process
K6968_RS07445	COG3091	SprT-like family
K6968_RS07455	COG0656	L-ascorbic acid biosynthetic process
K6968_RS07460	COG4708	membrane
K6968_RS07465	COG2246	polysaccharide biosynthetic process
K6968_RS07475	COG0024	Methionine aminopeptidase
K6968_RS07485	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K6968_RS07490	COG2249	NAD(P)H dehydrogenase (quinone) activity
K6968_RS07495	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K6968_RS07500	COG2131	deaminase
K6968_RS07510	COG1363	Peptidase, m42
K6968_RS07525	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K6968_RS07530	COG1956	GAF domain-containing protein
K6968_RS07540	COG1695	Transcriptional regulator
K6968_RS07555	COG0513	Belongs to the DEAD box helicase family
K6968_RS07560	COG0726	polysaccharide deacetylase
K6968_RS07580	COG0183	Belongs to the thiolase family
K6968_RS07585	COG3425	synthase
K6968_RS07610	COG0776	regulation of translation
K6968_RS07620	COG2755	lipolytic protein G-D-S-L family
K6968_RS07625	COG1307	EDD domain protein, DegV family
K6968_RS07630	COG0497	DNA recombination
K6968_RS07635	COG1438	arginine binding
K6968_RS07640	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
K6968_RS07650	COG1722	exodeoxyribonuclease VII activity
K6968_RS07655	COG1570	exodeoxyribonuclease VII activity
K6968_RS07660	COG2321	neutral zinc metallopeptidase
K6968_RS07665	COG1755	Isoprenylcysteine carboxyl methyltransferase
K6968_RS07670	COG5002	protein histidine kinase activity
K6968_RS07675	COG0745	RESPONSE REGULATOR receiver
K6968_RS07700	COG1227	inorganic diphosphatase activity
K6968_RS07710	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K6968_RS07715	COG1253	flavin adenine dinucleotide binding
K6968_RS07720	COG1119	ATPase activity
K6968_RS07725	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
K6968_RS07735	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K6968_RS07740	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K6968_RS07755	COG4470	Protein conserved in bacteria
K6968_RS07760	COG3480	Lon protease (S16) C-terminal proteolytic domain
K6968_RS07765	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K6968_RS07770	COG0742	ribosomal rna small subunit methyltransferase
K6968_RS07780	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6968_RS07785	COG4483	Protein conserved in bacteria
K6968_RS07790	COG2197	response regulator
K6968_RS07795	COG2203	Gaf domain
K6968_RS07795	COG4585	Histidine kinase
K6968_RS07800	COG0842	Transport permease protein
K6968_RS07805	COG1131	(ABC) transporter
K6968_RS07820	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K6968_RS07835	COG0671	phosphoesterase, PA-phosphatase related
K6968_RS07840	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
K6968_RS07850	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K6968_RS07855	COG1187	pseudouridine synthase activity
K6968_RS07860	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K6968_RS07865	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K6968_RS07870	COG0582	viral genome integration into host DNA
K6968_RS07890	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K6968_RS07895	COG3763	UPF0154 protein
K6968_RS07905	COG3579	cysteine-type endopeptidase activity
K6968_RS07920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6968_RS07925	COG1254	Belongs to the acylphosphatase family
K6968_RS07935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6968_RS07940	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K6968_RS07950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K6968_RS07960	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K6968_RS07970	COG1160	GTP binding
K6968_RS07980	COG1484	DNA-dependent DNA replication
K6968_RS07990	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K6968_RS07995	COG0628	permease
K6968_RS08000	COG0745	RESPONSE REGULATOR receiver
K6968_RS08005	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K6968_RS08015	COG0492	ferredoxin-NADP+ reductase activity
K6968_RS08025	COG0513	Belongs to the DEAD box helicase family
K6968_RS08035	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6968_RS08040	COG0768	penicillin binding
K6968_RS08050	COG0275	rRNA processing
K6968_RS08100	COG4939	FMN-binding domain protein
K6968_RS08105	COG0142	geranyltranstransferase activity
K6968_RS08110	COG1252	NADH dehydrogenase
K6968_RS08120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6968_RS08125	COG0569	domain protein
K6968_RS08130	COG0534	Mate efflux family protein
K6968_RS08140	COG4224	UPF0291 protein
K6968_RS08145	COG0751	glycine-tRNA ligase activity
K6968_RS08170	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K6968_RS08175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6968_RS08180	COG1464	Belongs to the NlpA lipoprotein family
K6968_RS08185	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K6968_RS08190	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K6968_RS08195	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K6968_RS08200	COG2252	PERMEase
K6968_RS08205	COG0561	phosphatase activity
K6968_RS08215	COG3715	PTS system
K6968_RS08220	COG3716	PTS system mannose fructose sorbose family IID component
K6968_RS08245	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K6968_RS08290	COG0439	Biotin carboxylase
K6968_RS08310	COG1028	Short-chain dehydrogenase reductase Sdr
K6968_RS08315	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K6968_RS08320	COG2070	2-Nitropropane dioxygenase
K6968_RS08330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6968_RS08340	COG1024	Enoyl-CoA hydratase
K6968_RS08345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6968_RS08350	COG0527	aspartate kinase activity
K6968_RS08355	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K6968_RS08360	COG0736	holo-[acyl-carrier-protein] synthase activity
K6968_RS08365	COG0653	protein targeting
K6968_RS08375	COG1940	carbohydrate kinase activity
K6968_RS08380	COG2190	(PTS) system
K6968_RS08380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6968_RS08380	COG1263	PTS System
K6968_RS08385	COG1621	beta-fructofuranosidase activity
K6968_RS08390	COG1609	Transcriptional regulator
K6968_RS08395	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K6968_RS08410	COG0006	proline dipeptidase activity
K6968_RS08415	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K6968_RS08430	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K6968_RS08435	COG0629	single-stranded DNA binding
K6968_RS08445	COG2826	transposase and inactivated derivatives, IS30 family
K6968_RS08450	COG0095	Lipoate-protein ligase
K6968_RS08465	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6968_RS08470	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6968_RS08470	COG0022	dehydrogenase e1 component
K6968_RS08475	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K6968_RS08480	COG2860	membrane
K6968_RS08495	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K6968_RS08500	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K6968_RS08510	COG2740	Nucleic-acid-binding protein implicated in transcription termination
K6968_RS08515	COG0195	Participates in both transcription termination and antitermination
K6968_RS08525	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K6968_RS08535	COG4473	ABC transporter
K6968_RS08540	COG1131	(ABC) transporter
K6968_RS08545	COG0537	adenosine 5'-monophosphoramidase activity
K6968_RS08555	COG1316	TRANSCRIPTIONal
K6968_RS08565	COG0802	atpase or kinase
K6968_RS08570	COG1461	Dihydroxyacetone kinase
K6968_RS08590	COG0601	transmembrane transport
K6968_RS08595	COG4608	Belongs to the ABC transporter superfamily
K6968_RS08610	COG1686	Belongs to the peptidase S11 family
K6968_RS08625	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K6968_RS08630	COG0719	Fe-S assembly protein
K6968_RS08640	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6968_RS08645	COG4862	establishment of competence for transformation
K6968_RS08650	COG1968	undecaprenyl-diphosphatase activity
K6968_RS08655	COG0765	amino acid transport
K6968_RS08675	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K6968_RS08680	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K6968_RS08685	COG0440	acetolactate synthase activity
K6968_RS08690	COG0028	Belongs to the TPP enzyme family
K6968_RS08710	COG0129	dihydroxy-acid dehydratase activity
K6968_RS08720	COG2151	metal-sulfur cluster biosynthetic enzyme
K6968_RS08735	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K6968_RS08750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6968_RS08775	COG3842	ATPase activity
K6968_RS08785	COG2207	Transcriptional regulator
K6968_RS08785	COG4753	response regulator
K6968_RS08790	COG2972	Histidine kinase
K6968_RS08805	COG1653	transport
K6968_RS08810	COG0395	ABC-type sugar transport system, permease component
K6968_RS08815	COG1175	transmembrane transport
K6968_RS08830	COG0383	alpha-mannosidase activity
K6968_RS08850	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
K6968_RS08865	COG1045	serine acetyltransferase
K6968_RS08870	COG1185	polyribonucleotide nucleotidyltransferase activity
K6968_RS08890	COG1263	PTS System
K6968_RS08890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6968_RS08900	COG1737	Transcriptional regulator
K6968_RS08905	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K6968_RS08925	COG1187	pseudouridine synthase activity
K6968_RS08945	COG0242	peptide deformylase activity
K6968_RS08955	COG0066	3-isopropylmalate dehydratase activity
K6968_RS08980	COG2309	aminopeptidase activity
K6968_RS08995	COG2176	DNA-directed DNA polymerase activity
K6968_RS09000	COG2376	Dihydroxyacetone kinase
K6968_RS09010	COG2376	Dihydroxyacetone kinase
K6968_RS09015	COG1461	Dihydroxyacetone kinase
K6968_RS09020	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
K6968_RS09025	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K6968_RS09030	COG0442	prolyl-tRNA aminoacylation
K6968_RS09040	COG4589	Belongs to the CDS family
K6968_RS09045	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K6968_RS09050	COG1862	Preprotein translocase
K6968_RS09060	COG1181	Belongs to the D-alanine--D-alanine ligase family
K6968_RS09060	COG2918	glutathione biosynthetic process
K6968_RS09070	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K6968_RS09075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6968_RS09090	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K6968_RS09100	COG4463	regulation of RNA biosynthetic process
K6968_RS09115	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K6968_RS09150	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K6968_RS09155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6968_RS09160	COG0492	ferredoxin-NADP+ reductase activity
K6968_RS09165	COG0564	pseudouridine synthase activity
K6968_RS09170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K6968_RS09190	COG1564	THIamine pyrophosphokinase
K6968_RS09200	COG1162	GTPase activity
K6968_RS09245	COG4115	mRNA cleavage
K6968_RS09280	COG0084	hydrolase, TatD family'
K6968_RS09290	COG1847	R3H domain protein
K6968_RS09300	COG0594	ribonuclease P activity
K6968_RS09305	COG0165	Argininosuccinate lyase
K6968_RS09310	COG0137	argininosuccinate synthase activity
K6968_RS09320	COG1827	regulation of RNA biosynthetic process
K6968_RS09335	COG2040	homocysteine
K6968_RS09340	COG0833	amino acid
K6968_RS09385	COG0756	dUTP diphosphatase activity
K6968_RS09390	COG1132	(ABC) transporter
K6968_RS09395	COG1132	(ABC) transporter
K6968_RS09405	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K6968_RS09410	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K6968_RS09415	COG0705	Rhomboid family
K6968_RS09420	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K6968_RS09425	COG1473	amidohydrolase
K6968_RS09430	COG2171	N-acyltransferase activity
K6968_RS09445	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K6968_RS09470	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K6968_RS09495	COG3623	hexulose-6-phosphate isomerase
K6968_RS09520	COG1523	belongs to the glycosyl hydrolase 13 family
K6968_RS09525	COG1609	Transcriptional regulator
K6968_RS09530	COG1126	abc transporter atp-binding protein
K6968_RS09535	COG0765	amino acid transport
K6968_RS09540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6968_RS09545	COG3942	CHAP domain
K6968_RS09550	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K6968_RS09560	COG1447	Phosphotransferase system cellobiose-specific component IIA
K6968_RS09570	COG3711	transcriptional antiterminator
K6968_RS09570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6968_RS09580	COG2723	6-phospho-beta-galactosidase activity
K6968_RS09585	COG1486	melibiose metabolic process
K6968_RS09595	COG3590	peptidase
K6968_RS09600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K6968_RS09605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K6968_RS09605	COG1321	iron dependent repressor
K6968_RS09610	COG1121	(ABC) transporter
K6968_RS09615	COG0803	Belongs to the bacterial solute-binding protein 9 family
K6968_RS09650	COG1490	D-aminoacyl-tRNA deacylase activity
K6968_RS09660	COG0737	Belongs to the 5'-nucleotidase family
K6968_RS09705	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K6968_RS09730	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K6968_RS09755	COG0737	Belongs to the 5'-nucleotidase family
K6968_RS09760	COG1328	CTP reductase activity
K6968_RS09790	COG1438	arginine binding
K6968_RS09795	COG0018	arginyl-trna synthetase
K6968_RS09815	COG1640	4-alpha-glucanotransferase
K6968_RS09820	COG2182	Extracellular solute-binding protein
K6968_RS09825	COG1175	transmembrane transport
K6968_RS09830	COG3833	ABC-type maltose transport systems, permease component
K6968_RS09835	COG5521	maltodextrose utilization protein MalA
K6968_RS09840	COG1609	Transcriptional regulator
K6968_RS09845	COG1523	belongs to the glycosyl hydrolase 13 family
K6968_RS09850	COG1780	Probably involved in ribonucleotide reductase function
K6968_RS09855	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6968_RS09860	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K6968_RS09865	COG2153	protein acetylation
K6968_RS09870	COG4989	oxidoreductase activity
K6968_RS09875	COG1216	Glycosyl transferase, family 2
K6968_RS09880	COG1472	Belongs to the glycosyl hydrolase 3 family
K6968_RS09920	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K6968_RS09930	COG0305	Participates in initiation and elongation during chromosome replication
K6968_RS09935	COG0359	binds to the 23S rRNA
K6968_RS09945	COG0445	tRNA wobble uridine modification
K6968_RS09960	COG1051	belongs to the nudix hydrolase family
K6968_RS09965	COG1733	regulation of RNA biosynthetic process
K6968_RS09975	COG0482	sulfurtransferase activity
K6968_RS09980	COG1760	l-serine dehydratase
K6968_RS09985	COG1760	l-serine dehydratase
K6968_RS09995	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
K6968_RS10000	COG1122	ATPase activity
K6968_RS10005	COG1122	ATPase activity
K6968_RS10010	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K6968_RS10015	COG1426	Protein conserved in bacteria
K6968_RS10020	COG0612	Peptidase, M16
K6968_RS10025	COG0612	Peptidase, M16
K6968_RS10035	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K6968_RS10040	COG0516	GMP reductase activity
K6968_RS10040	COG0517	IMP dehydrogenase activity
K6968_RS10050	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6968_RS10055	COG0488	(ABC) transporter
K6968_RS10085	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K6968_RS10090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6968_RS10095	COG1475	DNA binding
K6968_RS10160	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K6968_RS10170	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K6968_RS10175	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis