locus-tag	class	description
D2E16_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D2E16_RS00010	COG0592	DNA-directed DNA polymerase activity
D2E16_RS00030	COG0012	GTP binding
D2E16_RS00035	COG0193	aminoacyl-tRNA hydrolase activity
D2E16_RS00040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D2E16_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D2E16_RS00060	COG0037	tRNA processing
D2E16_RS00070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D2E16_RS00195	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D2E16_RS00200	COG0436	Aminotransferase
D2E16_RS00205	COG1381	Involved in DNA repair and RecF pathway recombination
D2E16_RS00210	COG0416	fatty acid biosynthetic process
D2E16_RS00215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D2E16_RS00225	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D2E16_RS00240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D2E16_RS00250	COG0138	bifunctional purine biosynthesis protein purh
D2E16_RS00265	COG3583	domain protein
D2E16_RS00275	COG0151	Belongs to the GarS family
D2E16_RS00280	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D2E16_RS00295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D2E16_RS00315	COG1131	(ABC) transporter
D2E16_RS00325	COG1132	(ABC) transporter
D2E16_RS00330	COG0789	Transcriptional regulator
D2E16_RS00335	COG2255	four-way junction helicase activity
D2E16_RS00340	COG0546	phosphoglycolate phosphatase activity
D2E16_RS00355	COG0285	dihydrofolate synthase activity
D2E16_RS00365	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D2E16_RS00370	COG0632	four-way junction helicase activity
D2E16_RS00375	COG0519	Catalyzes the synthesis of GMP from XMP
D2E16_RS00385	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D2E16_RS00390	COG1393	Belongs to the ArsC family
D2E16_RS00395	COG4472	Bacterial protein of unknown function (DUF965)
D2E16_RS00400	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D2E16_RS00405	COG3906	Belongs to the UPF0473 family
D2E16_RS00420	COG0051	transcription antitermination factor activity, RNA binding
D2E16_RS00425	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D2E16_RS00430	COG0088	Forms part of the polypeptide exit tunnel
D2E16_RS00435	COG0089	rRNA binding
D2E16_RS00440	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D2E16_RS00445	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D2E16_RS00450	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D2E16_RS00455	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D2E16_RS00460	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D2E16_RS00465	COG0255	Belongs to the universal ribosomal protein uL29 family
D2E16_RS00470	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D2E16_RS00475	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D2E16_RS00480	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D2E16_RS00485	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D2E16_RS00490	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D2E16_RS00495	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D2E16_RS00500	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D2E16_RS00505	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D2E16_RS00510	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D2E16_RS00515	COG1841	ribosomal large subunit assembly
D2E16_RS00525	COG0201	protein transport
D2E16_RS00530	COG0563	adenylate kinase activity
D2E16_RS00535	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D2E16_RS00540	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D2E16_RS00545	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D2E16_RS00555	COG0202	RNA polymerase activity
D2E16_RS00580	COG4372	Transposase
D2E16_RS00675	COG0582	viral genome integration into host DNA
D2E16_RS00705	COG4372	Transposase
D2E16_RS00730	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D2E16_RS00755	COG1674	ftsk spoiiie
D2E16_RS00775	COG1121	(ABC) transporter
D2E16_RS00780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D2E16_RS00785	COG0803	Belongs to the bacterial solute-binding protein 9 family
D2E16_RS00785	COG3443	Belongs to the bacterial solute-binding protein 9 family
D2E16_RS00815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D2E16_RS00820	COG0085	RNA polymerase activity
D2E16_RS00825	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D2E16_RS00835	COG4372	Transposase
D2E16_RS00855	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D2E16_RS00860	COG1459	type II secretion system
D2E16_RS00865	COG4537	Required for transformation and DNA binding
D2E16_RS00895	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D2E16_RS00905	COG0285	dihydrofolate synthase activity
D2E16_RS00920	COG1363	Peptidase, m42
D2E16_RS00930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D2E16_RS00940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D2E16_RS00965	COG0459	protein refolding
D2E16_RS00975	COG0049	tRNA binding
D2E16_RS00980	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D2E16_RS00990	COG0126	phosphoglycerate kinase activity
D2E16_RS01000	COG0789	Transcriptional regulator
D2E16_RS01005	COG0174	glutamine synthetase
D2E16_RS01020	COG1396	sequence-specific DNA binding
D2E16_RS01035	COG1214	PFAM Peptidase M22, glycoprotease
D2E16_RS01045	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D2E16_RS01080	COG2855	membrane
D2E16_RS01090	COG1131	(ABC) transporter
D2E16_RS01100	COG2081	HI0933 family
D2E16_RS01125	COG0584	glycerophosphoryl diester phosphodiesterase
D2E16_RS01130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D2E16_RS01135	COG2222	sugar isomerase
D2E16_RS01155	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D2E16_RS01160	COG1882	Formate acetyltransferase
D2E16_RS01165	COG0366	Alpha amylase catalytic
D2E16_RS01165	COG0366	Alpha amylase catalytic
D2E16_RS01190	COG2910	NAD(P)H-binding
D2E16_RS01220	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D2E16_RS01225	COG0681	Belongs to the peptidase S26 family
D2E16_RS01250	COG0366	Alpha amylase catalytic
D2E16_RS01255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2E16_RS01255	COG1263	PTS System
D2E16_RS01260	COG2188	Transcriptional regulator
D2E16_RS01275	COG1193	negative regulation of DNA recombination
D2E16_RS01305	COG3279	Response regulator of the LytR AlgR family
D2E16_RS01320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D2E16_RS01325	COG2274	protein secretion by the type I secretion system
D2E16_RS01360	COG3118	belongs to the thioredoxin family
D2E16_RS01380	COG3118	belongs to the thioredoxin family
D2E16_RS01385	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D2E16_RS01385	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D2E16_RS01395	COG1136	(ABC) transporter
D2E16_RS01400	COG1115	amino acid carrier protein
D2E16_RS01405	COG0668	transmembrane transport
D2E16_RS01415	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D2E16_RS01420	COG0167	dihydroorotate dehydrogenase activity
D2E16_RS01425	COG2843	Capsule synthesis protein
D2E16_RS01430	COG0561	phosphatase activity
D2E16_RS01445	COG1131	(ABC) transporter
D2E16_RS01450	COG1309	transcriptional regulator
D2E16_RS01455	COG1511	domain protein
D2E16_RS01460	COG4152	abc transporter atp-binding protein
D2E16_RS01465	COG1668	transmembrane transport
D2E16_RS01490	COG1346	cytolysis
D2E16_RS01495	COG2116	formate transmembrane transporter activity
D2E16_RS01500	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D2E16_RS01510	COG0494	nUDIX hydrolase
D2E16_RS01520	COG1349	DNA-binding transcription factor activity
D2E16_RS01525	COG0698	ribose 5-phosphate isomerase
D2E16_RS01530	COG0698	ribose 5-phosphate isomerase
D2E16_RS01535	COG1105	Belongs to the carbohydrate kinase PfkB family
D2E16_RS01540	COG3684	Belongs to the aldolase LacD family
D2E16_RS01545	COG3711	transcriptional antiterminator
D2E16_RS01555	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D2E16_RS01555	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D2E16_RS01570	COG1408	metallophosphoesterase
D2E16_RS01585	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D2E16_RS01590	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D2E16_RS01605	COG0124	histidyl-tRNA synthetase
D2E16_RS01610	COG1064	alcohol dehydrogenase
D2E16_RS01615	COG1012	belongs to the aldehyde dehydrogenase family
D2E16_RS01615	COG1454	alcohol dehydrogenase
D2E16_RS01630	COG0732	type I restriction modification DNA specificity domain
D2E16_RS01650	COG4988	ABC transporter
D2E16_RS01655	COG1132	(ABC) transporter
D2E16_RS01670	COG1129	ABC transporter
D2E16_RS01675	COG0534	Mate efflux family protein
D2E16_RS01715	COG4372	Transposase
D2E16_RS01720	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D2E16_RS01735	COG1304	FMN binding
D2E16_RS01740	COG1132	(ABC) transporter
D2E16_RS01745	COG1132	(ABC) transporter
D2E16_RS01750	COG3830	Belongs to the UPF0237 family
D2E16_RS01755	COG2848	UPF0210 protein
D2E16_RS01765	COG0588	phosphoglycerate mutase activity
D2E16_RS01780	COG1420	regulation of RNA biosynthetic process
D2E16_RS01785	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D2E16_RS01790	COG0443	Heat shock 70 kDa protein
D2E16_RS01795	COG0484	heat shock protein binding
D2E16_RS01805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D2E16_RS01810	COG0765	amino acid transport
D2E16_RS01815	COG3655	Transcriptional regulator
D2E16_RS01825	COG2217	Heavy metal translocating P-type atpase
D2E16_RS01840	COG0351	phosphomethylpyrimidine kinase
D2E16_RS01850	COG4475	Protein of unknown function (DUF436)
D2E16_RS01865	COG1063	alcohol dehydrogenase
D2E16_RS01885	COG2910	NAD(P)H-binding
D2E16_RS01890	COG1959	2 iron, 2 sulfur cluster binding
D2E16_RS01910	COG0544	peptidyl-prolyl cis-trans isomerase activity
D2E16_RS01925	COG3343	RNA polymerase activity
D2E16_RS01930	COG0504	CTP synthase activity
D2E16_RS01940	COG0191	fructose-bisphosphate aldolase activity
D2E16_RS01945	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D2E16_RS01985	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D2E16_RS02010	COG0436	Aminotransferase
D2E16_RS02015	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
D2E16_RS02020	COG1335	isochorismatase
D2E16_RS02030	COG0335	large ribosomal subunit rRNA binding
D2E16_RS02040	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D2E16_RS02045	COG0154	amidase activity
D2E16_RS02050	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D2E16_RS02080	COG1609	Transcriptional regulator
D2E16_RS02085	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D2E16_RS02090	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
D2E16_RS02100	COG3142	Participates in the control of copper homeostasis
D2E16_RS02115	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D2E16_RS02120	COG1534	Rna-binding protein
D2E16_RS02125	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D2E16_RS02130	COG1713	HD superfamily hydrolase involved in NAD metabolism
D2E16_RS02140	COG1335	isochorismatase
D2E16_RS02145	COG0799	negative regulation of ribosome biogenesis
D2E16_RS02150	COG2226	methyltransferase
D2E16_RS02170	COG0789	Transcriptional regulator
D2E16_RS02175	COG2348	transferase activity, transferring amino-acyl groups
D2E16_RS02185	COG0242	peptide deformylase activity
D2E16_RS02195	COG1640	4-alpha-glucanotransferase
D2E16_RS02200	COG0058	SHG alpha-glucan phosphorylase activity
D2E16_RS02215	COG2190	(PTS) system
D2E16_RS02215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2E16_RS02215	COG1263	PTS System
D2E16_RS02220	COG0217	transcriptional regulatory protein
D2E16_RS02230	COG4720	Psort location CytoplasmicMembrane, score
D2E16_RS02240	COG1054	Belongs to the UPF0176 family
D2E16_RS02250	COG1122	ATPase activity
D2E16_RS02270	COG0357	Ribosomal RNA small subunit methyltransferase G
D2E16_RS02275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D2E16_RS02280	COG3331	DNA recombination
D2E16_RS02285	COG4474	Belongs to the UPF0398 family
D2E16_RS02290	COG3599	regulation of cell shape
D2E16_RS02310	COG1854	S-ribosylhomocysteine lyase activity
D2E16_RS02315	COG1418	mRNA catabolic process
D2E16_RS02325	COG1758	RNA polymerase activity
D2E16_RS02330	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D2E16_RS02335	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D2E16_RS02340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D2E16_RS02340	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D2E16_RS02345	COG0631	protein serine/threonine phosphatase activity
D2E16_RS02350	COG2815	serine threonine protein kinase
D2E16_RS02350	COG0515	serine threonine protein kinase
D2E16_RS02380	COG1098	S1 RNA binding domain
D2E16_RS02390	COG1739	Uncharacterized protein family UPF0029
D2E16_RS02395	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
D2E16_RS02510	COG2137	regulation of response to DNA damage stimulus
D2E16_RS02515	COG3557	Belongs to the UPF0374 family
D2E16_RS02525	COG2188	Transcriptional regulator
D2E16_RS02530	COG2188	Transcriptional regulator
D2E16_RS02540	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2E16_RS02550	COG3716	PTS system mannose fructose sorbose family IID component
D2E16_RS02560	COG2017	converts alpha-aldose to the beta-anomer
D2E16_RS02575	COG0346	lactoylglutathione lyase activity
D2E16_RS02615	COG1074	ATP-dependent DNA helicase activity
D2E16_RS02630	COG1217	gtp-binding protein TYPA
D2E16_RS02645	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D2E16_RS02660	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D2E16_RS02665	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D2E16_RS02670	COG1799	cell septum assembly
D2E16_RS02685	COG3599	regulation of cell shape
D2E16_RS02715	COG4372	Transposase
D2E16_RS02725	COG0494	nUDIX hydrolase
D2E16_RS02725	COG0406	alpha-ribazole phosphatase activity
D2E16_RS02730	COG0542	response to heat
D2E16_RS02735	COG4703	Protein of unknown function (DUF1797)
D2E16_RS02740	COG0765	amino acid transport
D2E16_RS02750	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D2E16_RS02780	COG0745	RESPONSE REGULATOR receiver
D2E16_RS02785	COG5002	protein histidine kinase activity
D2E16_RS02790	COG1755	Isoprenylcysteine carboxyl methyltransferase
D2E16_RS02800	COG1570	exodeoxyribonuclease VII activity
D2E16_RS02805	COG1722	exodeoxyribonuclease VII activity
D2E16_RS02815	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
D2E16_RS02820	COG1438	arginine binding
D2E16_RS02825	COG0497	DNA recombination
D2E16_RS02830	COG1307	EDD domain protein, DegV family
D2E16_RS02835	COG2755	lipolytic protein G-D-S-L family
D2E16_RS02845	COG0776	regulation of translation
D2E16_RS02865	COG3425	synthase
D2E16_RS02870	COG0183	Belongs to the thiolase family
D2E16_RS02885	COG0726	polysaccharide deacetylase
D2E16_RS02890	COG0513	Belongs to the DEAD box helicase family
D2E16_RS02895	COG0673	inositol 2-dehydrogenase activity
D2E16_RS02905	COG1695	Transcriptional regulator
D2E16_RS02920	COG1956	GAF domain-containing protein
D2E16_RS02925	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D2E16_RS02940	COG1363	Peptidase, m42
D2E16_RS02950	COG2131	deaminase
D2E16_RS02955	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D2E16_RS02960	COG2249	NAD(P)H dehydrogenase (quinone) activity
D2E16_RS02965	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D2E16_RS02975	COG0024	Methionine aminopeptidase
D2E16_RS02985	COG2246	polysaccharide biosynthetic process
D2E16_RS02990	COG4708	membrane
D2E16_RS02995	COG0656	L-ascorbic acid biosynthetic process
D2E16_RS03000	COG2183	response to ionizing radiation
D2E16_RS03005	COG3091	SprT-like family
D2E16_RS03020	COG1482	cell wall glycoprotein biosynthetic process
D2E16_RS03025	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
D2E16_RS03030	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D2E16_RS03045	COG1733	regulation of RNA biosynthetic process
D2E16_RS03050	COG0436	Aminotransferase
D2E16_RS03065	COG2205	protein histidine kinase activity
D2E16_RS03070	COG1136	(ABC) transporter
D2E16_RS03075	COG0577	efflux transmembrane transporter activity
D2E16_RS03105	COG1028	Short-chain dehydrogenase reductase Sdr
D2E16_RS03110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D2E16_RS03125	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D2E16_RS03130	COG0494	nUDIX hydrolase
D2E16_RS03155	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D2E16_RS03180	COG4209	transmembrane transport
D2E16_RS03185	COG0395	ABC-type sugar transport system, permease component
D2E16_RS03190	COG1653	transport
D2E16_RS03195	COG1621	beta-fructofuranosidase activity
D2E16_RS03200	COG0697	spore germination
D2E16_RS03200	COG1674	ftsk spoiiie
D2E16_RS03205	COG0346	lactoylglutathione lyase activity
D2E16_RS03230	COG4372	Transposase
D2E16_RS03265	COG0625	glutathione transferase activity
D2E16_RS03270	COG2244	polysaccharide biosynthetic process
D2E16_RS03275	COG0528	UMP kinase activity
D2E16_RS03280	COG0233	cytoplasmic translational termination
D2E16_RS03285	COG2996	Protein conserved in bacteria
D2E16_RS03300	COG4479	Belongs to the UPF0346 family
D2E16_RS03305	COG3583	domain protein
D2E16_RS03310	COG3583	domain protein
D2E16_RS03315	COG1702	phosphate starvation-inducible protein PhoH
D2E16_RS03320	COG3590	peptidase
D2E16_RS03335	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D2E16_RS03340	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D2E16_RS03345	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D2E16_RS03360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D2E16_RS03365	COG3022	response to hydroperoxide
D2E16_RS03370	COG1316	TRANSCRIPTIONal
D2E16_RS03375	COG3944	biosynthesis protein
D2E16_RS03385	COG4464	protein tyrosine phosphatase activity
D2E16_RS03395	COG3177	Filamentation induced by cAMP protein fic
D2E16_RS03400	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D2E16_RS03405	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D2E16_RS03410	COG1216	Glycosyl transferase, family 2
D2E16_RS03420	COG1216	Glycosyl transferase, family 2
D2E16_RS03420	COG1442	glycosyl transferase family 8
D2E16_RS03425	COG0438	transferase activity, transferring glycosyl groups
D2E16_RS03445	COG3475	LICD family
D2E16_RS03450	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D2E16_RS03460	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D2E16_RS03470	COG4750	Nucleotidyl transferase
D2E16_RS03490	COG0562	UDP-galactopyranose mutase
D2E16_RS03495	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D2E16_RS03515	COG0436	Aminotransferase
D2E16_RS03525	COG0534	Mate efflux family protein
D2E16_RS03530	COG0251	oxidation-reduction process
D2E16_RS03535	COG1660	Displays ATPase and GTPase activities
D2E16_RS03540	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D2E16_RS03545	COG1481	regulation of sporulation
D2E16_RS03560	COG0454	-acetyltransferase
D2E16_RS03565	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D2E16_RS03570	COG0549	Belongs to the carbamate kinase family
D2E16_RS03575	COG1288	antiporter activity
D2E16_RS03580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D2E16_RS03585	COG1438	arginine binding
D2E16_RS03590	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D2E16_RS03595	COG0363	glucosamine-6-phosphate deaminase activity
D2E16_RS03605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2E16_RS03610	COG1696	Membrane protein involved in D-alanine export
D2E16_RS03615	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D2E16_RS03620	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
D2E16_RS03635	COG0435	Glutathione S-transferase
D2E16_RS03640	COG1187	pseudouridine synthase activity
D2E16_RS03645	COG0386	Belongs to the glutathione peroxidase family
D2E16_RS03655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2E16_RS03660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2E16_RS03665	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D2E16_RS03670	COG1120	ATPase activity
D2E16_RS03675	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D2E16_RS03680	COG0204	Acyl-transferase
D2E16_RS03690	COG1555	photosystem II stabilization
D2E16_RS03690	COG1596	polysaccharide export
D2E16_RS03695	COG0658	competence protein
D2E16_RS03695	COG2333	competence protein COMEC
D2E16_RS03700	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
D2E16_RS03700	COG3583	domain protein
D2E16_RS03710	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D2E16_RS03715	COG0737	Belongs to the 5'-nucleotidase family
D2E16_RS03770	COG3561	AntA/AntB antirepressor
D2E16_RS04040	COG0038	chloride channel
D2E16_RS04045	COG1605	Chorismate mutase
D2E16_RS04045	COG0287	Prephenate dehydrogenase
D2E16_RS04055	COG0716	FMN binding
D2E16_RS04060	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D2E16_RS04080	COG0772	Belongs to the SEDS family
D2E16_RS04085	COG0693	protein deglycase activity
D2E16_RS04090	COG0187	DNA topoisomerase II activity
D2E16_RS04095	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
D2E16_RS04100	COG0560	Phosphoserine phosphatase
D2E16_RS04130	COG1011	Hydrolase
D2E16_RS04140	COG2706	6-phosphogluconolactonase activity
D2E16_RS04145	COG0628	permease
D2E16_RS04155	COG3527	Alpha-acetolactate decarboxylase
D2E16_RS04160	COG1293	RNA-binding protein homologous to eukaryotic snRNP
D2E16_RS04175	COG3842	ATPase activity
D2E16_RS04225	COG1216	Glycosyl transferase, family 2
D2E16_RS04225	COG1442	glycosyl transferase family 8
D2E16_RS04235	COG1216	Glycosyl transferase, family 2
D2E16_RS04235	COG1442	glycosyl transferase family 8
D2E16_RS04245	COG1215	transferase activity, transferring glycosyl groups
D2E16_RS04250	COG1442	glycosyl transferase family 8
D2E16_RS04255	COG1442	glycosyl transferase family 8
D2E16_RS04265	COG1442	glycosyl transferase family 8
D2E16_RS04265	COG1216	Glycosyl transferase, family 2
D2E16_RS04270	COG0201	protein transport
D2E16_RS04335	COG0488	(ABC) transporter
D2E16_RS04345	COG2226	methyltransferase
D2E16_RS04350	COG3442	glutamine amidotransferase
D2E16_RS04355	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D2E16_RS04370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D2E16_RS04375	COG0488	(ABC) transporter
D2E16_RS04380	COG0662	Cupin 2, conserved barrel domain protein
D2E16_RS04385	COG4619	ABC transporter
D2E16_RS04390	COG0390	transport system, permease component
D2E16_RS04410	COG1573	uracil-dna glycosylase
D2E16_RS04420	COG1704	LemA family
D2E16_RS04430	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D2E16_RS04435	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D2E16_RS04455	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D2E16_RS04460	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D2E16_RS04470	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D2E16_RS04475	COG0813	purine-nucleoside phosphorylase activity
D2E16_RS04480	COG0058	SHG alpha-glucan phosphorylase activity
D2E16_RS04490	COG1724	mRNA binding
D2E16_RS04500	COG0582	viral genome integration into host DNA
D2E16_RS04510	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D2E16_RS04520	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
D2E16_RS04525	COG3620	sequence-specific DNA binding
D2E16_RS04535	COG1216	Glycosyl transferase, family 2
D2E16_RS04550	COG1051	belongs to the nudix hydrolase family
D2E16_RS04555	COG0647	UMP catabolic process
D2E16_RS04565	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D2E16_RS04580	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D2E16_RS04585	COG1970	mechanosensitive ion channel activity
D2E16_RS04590	COG0358	DNA primase activity
D2E16_RS04595	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D2E16_RS04600	COG2151	metal-sulfur cluster biosynthetic enzyme
D2E16_RS04625	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D2E16_RS04635	COG1131	(ABC) transporter
D2E16_RS04640	COG2188	Transcriptional regulator
D2E16_RS04650	COG0205	6-phosphofructokinase activity
D2E16_RS04655	COG0469	pyruvate kinase activity
D2E16_RS04665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D2E16_RS04670	COG2755	lipolytic protein G-D-S-L family
D2E16_RS04670	COG0657	acetylesterase activity
D2E16_RS04680	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D2E16_RS04700	COG4372	Transposase
D2E16_RS04705	COG2213	PTS system mannitol-specific
D2E16_RS04710	COG3711	transcriptional antiterminator
D2E16_RS04715	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D2E16_RS04725	COG0765	amino acid transport
D2E16_RS04730	COG1126	abc transporter atp-binding protein
D2E16_RS04735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D2E16_RS04750	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D2E16_RS04765	COG1846	Transcriptional regulator
D2E16_RS04770	COG3759	membrane
D2E16_RS04805	COG2195	Cleaves the N-terminal amino acid of tripeptides
D2E16_RS04810	COG0561	phosphatase activity
D2E16_RS04830	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
D2E16_RS04845	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D2E16_RS04850	COG0196	riboflavin kinase activity
D2E16_RS04855	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D2E16_RS04860	COG1393	Belongs to the ArsC family
D2E16_RS04865	COG4476	Belongs to the UPF0223 family
D2E16_RS04870	COG0483	inositol monophosphate 1-phosphatase activity
D2E16_RS04875	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
D2E16_RS04875	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D2E16_RS04885	COG0573	inorganic phosphate transmembrane transporter activity
D2E16_RS04890	COG0581	inorganic phosphate transmembrane transporter activity
D2E16_RS04895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D2E16_RS04900	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D2E16_RS04920	COG0745	RESPONSE REGULATOR receiver
D2E16_RS04925	COG5002	protein histidine kinase activity
D2E16_RS04940	COG0268	Binds directly to 16S ribosomal RNA
D2E16_RS04945	COG1072	(Pantothenic acid kinase))
D2E16_RS04950	COG2813	Specifically methylates the guanine in position
D2E16_RS04955	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
D2E16_RS04965	COG0295	cytidine deaminase activity
D2E16_RS04970	COG1744	ABC transporter substrate-binding protein PnrA-like
D2E16_RS04975	COG3845	ABC transporter
D2E16_RS04980	COG4603	Belongs to the binding-protein-dependent transport system permease family
D2E16_RS04985	COG1079	Belongs to the binding-protein-dependent transport system permease family
D2E16_RS05005	COG4372	Transposase
D2E16_RS05010	COG0039	L-malate dehydrogenase activity
D2E16_RS05015	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D2E16_RS05020	COG3764	Sortase (surface protein transpeptidase)
D2E16_RS05030	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D2E16_RS05035	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
D2E16_RS05050	COG1104	cysteine desulfurase activity
D2E16_RS05060	COG4116	CYTH
D2E16_RS05095	COG1396	sequence-specific DNA binding
D2E16_RS05275	COG1475	DNA binding
D2E16_RS05410	COG5632	N-Acetylmuramoyl-L-alanine amidase
D2E16_RS05410	COG3409	Peptidoglycan-binding domain 1 protein
D2E16_RS05420	COG2357	RelA SpoT domain protein
D2E16_RS05425	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D2E16_RS05430	COG0564	pseudouridine synthase activity
D2E16_RS05435	COG0280	phosphate acetyltransferase
D2E16_RS05440	COG1132	(ABC) transporter
D2E16_RS05445	COG1132	(ABC) transporter
D2E16_RS05460	COG1396	sequence-specific DNA binding
D2E16_RS05475	COG1454	alcohol dehydrogenase
D2E16_RS05480	COG2873	o-acetylhomoserine
D2E16_RS05485	COG0488	(ABC) transporter
D2E16_RS05495	COG1126	abc transporter atp-binding protein
D2E16_RS05520	COG0494	nUDIX hydrolase
D2E16_RS05525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D2E16_RS05530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D2E16_RS05545	COG0297	glycogen (starch) synthase activity
D2E16_RS05555	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D2E16_RS05565	COG0543	2 iron, 2 sulfur cluster binding
D2E16_RS05570	COG0167	dihydroorotate dehydrogenase activity
D2E16_RS05575	COG0284	orotidine-5'-phosphate decarboxylase activity
D2E16_RS05580	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D2E16_RS05590	COG0463	Glycosyl transferase, family 2
D2E16_RS05595	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D2E16_RS05605	COG0737	Belongs to the 5'-nucleotidase family
D2E16_RS05610	COG0424	maF-like protein
D2E16_RS05635	COG1070	Carbohydrate kinase
D2E16_RS05655	COG1175	transmembrane transport
D2E16_RS05660	COG0395	ABC-type sugar transport system, permease component
D2E16_RS05675	COG1940	carbohydrate kinase activity
D2E16_RS05685	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D2E16_RS05690	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D2E16_RS05700	COG1272	protein, Hemolysin III
D2E16_RS05710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D2E16_RS05710	COG0425	Belongs to the sulfur carrier protein TusA family
D2E16_RS05715	COG0110	maltose O-acetyltransferase activity
D2E16_RS05720	COG0758	DNA mediated transformation
D2E16_RS05725	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D2E16_RS05730	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D2E16_RS05735	COG0222	ribosome binding
D2E16_RS05750	COG0270	DNA (cytosine-5-)-methyltransferase activity
D2E16_RS05820	COG4509	Sortase family
D2E16_RS05825	COG0741	lytic transglycosylase activity
D2E16_RS05825	COG0791	NLP P60 protein
D2E16_RS05855	COG1181	Belongs to the D-alanine--D-alanine ligase family
D2E16_RS05880	COG2337	Toxic component of a toxin-antitoxin (TA) module
D2E16_RS05945	COG2226	methyltransferase
D2E16_RS05955	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D2E16_RS05970	COG2378	regulation of single-species biofilm formation
D2E16_RS06075	COG1396	sequence-specific DNA binding
D2E16_RS06080	COG0542	response to heat
D2E16_RS06110	COG3843	relaxase mobilization nuclease domain protein
D2E16_RS06115	COG2205	protein histidine kinase activity
D2E16_RS06120	COG0745	RESPONSE REGULATOR receiver
D2E16_RS06155	COG0647	UMP catabolic process
D2E16_RS06160	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
D2E16_RS06165	COG2382	esterase
D2E16_RS06195	COG0577	efflux transmembrane transporter activity
D2E16_RS06210	COG0745	RESPONSE REGULATOR receiver
D2E16_RS06225	COG4974	Belongs to the 'phage' integrase family
D2E16_RS06240	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D2E16_RS06245	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
D2E16_RS06250	COG2188	Transcriptional regulator
D2E16_RS06260	COG4268	DNA restriction-modification system
D2E16_RS06265	COG1401	restriction endodeoxyribonuclease activity
D2E16_RS06290	COG4221	oxidoreductase activity
D2E16_RS06295	COG0741	lytic transglycosylase activity
D2E16_RS06305	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D2E16_RS06315	COG0009	L-threonylcarbamoyladenylate synthase
D2E16_RS06320	COG2890	protein-(glutamine-N5) methyltransferase activity
D2E16_RS06325	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D2E16_RS06350	COG0481	GTPase activity
D2E16_RS06365	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D2E16_RS06370	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D2E16_RS06375	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D2E16_RS06385	COG1940	carbohydrate kinase activity
D2E16_RS06395	COG0488	(ABC) transporter
D2E16_RS06400	COG0617	tRNA 3'-terminal CCA addition
D2E16_RS06405	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D2E16_RS06410	COG1307	EDD domain protein, DegV family
D2E16_RS06420	COG3583	domain protein
D2E16_RS06425	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D2E16_RS06425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D2E16_RS06425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D2E16_RS06430	COG1105	Belongs to the carbohydrate kinase PfkB family
D2E16_RS06435	COG1349	DNA-binding transcription factor activity
D2E16_RS06440	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D2E16_RS06445	COG0336	Belongs to the RNA methyltransferase TrmD family
D2E16_RS06450	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D2E16_RS06460	COG0534	Mate efflux family protein
D2E16_RS06470	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D2E16_RS06475	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D2E16_RS06490	COG0038	chloride channel
D2E16_RS06500	COG1177	transmembrane transport
D2E16_RS06505	COG1176	ABC-type spermidine putrescine transport system, permease component I
D2E16_RS06510	COG3842	ATPase activity
D2E16_RS06515	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D2E16_RS06520	COG0083	homoserine kinase activity
D2E16_RS06530	COG0726	polysaccharide deacetylase
D2E16_RS06535	COG1132	(ABC) transporter
D2E16_RS06550	COG0228	four-way junction DNA binding
D2E16_RS06560	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D2E16_RS06565	COG2136	Putative SAM-dependent methyltransferase
D2E16_RS06565	COG2521	methyltransferase
D2E16_RS06575	COG0505	Belongs to the CarA family
D2E16_RS06580	COG0540	Belongs to the ATCase OTCase family
D2E16_RS06585	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D2E16_RS06595	COG2824	Alkylphosphonate utilization operon protein PhnA
D2E16_RS06600	COG0564	pseudouridine synthase activity
D2E16_RS06620	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D2E16_RS06625	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D2E16_RS06635	COG0301	tRNA thio-modification
D2E16_RS06640	COG1104	cysteine desulfurase activity
D2E16_RS06665	COG0539	negative regulation of cytoplasmic translation
D2E16_RS06685	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D2E16_RS06705	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D2E16_RS06715	COG2184	nucleotidyltransferase activity
D2E16_RS06720	COG0187	DNA topoisomerase II activity
D2E16_RS06730	COG1074	ATP-dependent DNA helicase activity
D2E16_RS06770	COG1131	(ABC) transporter
D2E16_RS06795	COG1011	Hydrolase
D2E16_RS06805	COG0210	DNA helicase
D2E16_RS06810	COG3177	Filamentation induced by cAMP protein fic
D2E16_RS06830	COG1164	Oligoendopeptidase f
D2E16_RS06840	COG0346	lactoylglutathione lyase activity
D2E16_RS06845	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D2E16_RS06850	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D2E16_RS06855	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D2E16_RS06865	COG0446	pyridine nucleotide-disulphide oxidoreductase
D2E16_RS06870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D2E16_RS06875	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D2E16_RS06895	COG1882	Formate acetyltransferase
D2E16_RS06900	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D2E16_RS06905	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D2E16_RS06910	COG1447	Phosphotransferase system cellobiose-specific component IIA
D2E16_RS06920	COG1349	DNA-binding transcription factor activity
D2E16_RS06925	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D2E16_RS06950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D2E16_RS06960	COG2759	Belongs to the formate--tetrahydrofolate ligase family
D2E16_RS06970	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D2E16_RS06975	COG4684	Psort location CytoplasmicMembrane, score
D2E16_RS06980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D2E16_RS07075	COG0740	serine-type endopeptidase activity
D2E16_RS07080	COG4695	Portal protein
D2E16_RS07120	COG0270	DNA (cytosine-5-)-methyltransferase activity
D2E16_RS07150	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D2E16_RS07200	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D2E16_RS07200	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D2E16_RS07235	COG0488	(ABC) transporter
D2E16_RS07265	COG0456	acetyltransferase
D2E16_RS07315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D2E16_RS07325	COG0077	Prephenate dehydratase
D2E16_RS07330	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D2E16_RS07340	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D2E16_RS07345	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D2E16_RS07350	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D2E16_RS07355	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D2E16_RS07360	COG1116	anion transmembrane transporter activity
D2E16_RS07360	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D2E16_RS07365	COG4120	Belongs to the binding-protein-dependent transport system permease family
D2E16_RS07400	COG3684	Belongs to the aldolase LacD family
D2E16_RS07410	COG3679	Belongs to the UPF0342 family
D2E16_RS07415	COG0287	Prephenate dehydrogenase
D2E16_RS07420	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D2E16_RS07425	COG0710	3-dehydroquinate dehydratase activity
D2E16_RS07430	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D2E16_RS07435	COG1368	sulfuric ester hydrolase activity
D2E16_RS07460	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D2E16_RS07495	COG1216	Glycosyl transferase, family 2
D2E16_RS07510	COG1216	Glycosyl transferase, family 2
D2E16_RS07510	COG1442	glycosyl transferase family 8
D2E16_RS07515	COG1442	glycosyl transferase family 8
D2E16_RS07545	COG1216	Glycosyl transferase, family 2
D2E16_RS07545	COG1442	glycosyl transferase family 8
D2E16_RS07570	COG1091	dTDP-4-dehydrorhamnose reductase activity
D2E16_RS07575	COG1088	dTDP-glucose 4,6-dehydratase activity
D2E16_RS07580	COG0135	phosphoribosylanthranilate isomerase activity
D2E16_RS07590	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
D2E16_RS07600	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D2E16_RS07605	COG2384	SAM-dependent methyltransferase
D2E16_RS07620	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D2E16_RS07630	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D2E16_RS07630	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D2E16_RS07635	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D2E16_RS07640	COG2217	Heavy metal translocating P-type atpase
D2E16_RS07645	COG0300	oxidoreductase activity
D2E16_RS07650	COG1234	tRNA 3'-trailer cleavage
D2E16_RS07660	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D2E16_RS07665	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D2E16_RS07675	COG2807	transmembrane transport
D2E16_RS07680	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D2E16_RS07690	COG2610	gluconate transmembrane transporter activity
D2E16_RS07710	COG0302	gtp cyclohydrolase
D2E16_RS07715	COG1051	belongs to the nudix hydrolase family
D2E16_RS07740	COG0072	phenylalanine-tRNA ligase activity
D2E16_RS07740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D2E16_RS07765	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D2E16_RS07775	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D2E16_RS07780	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D2E16_RS07785	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D2E16_RS07790	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D2E16_RS07795	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D2E16_RS07800	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D2E16_RS07805	COG0356	it plays a direct role in the translocation of protons across the membrane
D2E16_RS07815	COG1597	lipid kinase activity
D2E16_RS07830	COG0701	Predicted permease
D2E16_RS07835	COG3689	TIGRFAM TIGR03943 family protein
D2E16_RS07840	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D2E16_RS07850	COG0552	protein localization to endoplasmic reticulum
D2E16_RS07855	COG0561	phosphatase activity
D2E16_RS07860	COG0561	phosphatase activity
D2E16_RS07865	COG1196	nuclear chromosome segregation
D2E16_RS07890	COG4868	Belongs to the UPF0371 family
D2E16_RS07895	COG1012	belongs to the aldehyde dehydrogenase family
D2E16_RS07910	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D2E16_RS07915	COG0538	isocitrate dehydrogenase activity
D2E16_RS07920	COG0372	Belongs to the citrate synthase family
D2E16_RS07925	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D2E16_RS07930	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D2E16_RS07935	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D2E16_RS07940	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D2E16_RS07975	COG1476	TRANSCRIPTIONal
D2E16_RS08000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D2E16_RS08010	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D2E16_RS08020	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D2E16_RS08025	COG4122	O-methyltransferase activity
D2E16_RS08050	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D2E16_RS08050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D2E16_RS08090	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D2E16_RS08110	COG0531	amino acid
D2E16_RS08120	COG0708	Exodeoxyribonuclease III
D2E16_RS08160	COG1393	Belongs to the ArsC family
D2E16_RS08165	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D2E16_RS08170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D2E16_RS08180	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D2E16_RS08190	COG4467	Involved in initiation control of chromosome replication
D2E16_RS08195	COG0470	DNA polymerase III
D2E16_RS08200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D2E16_RS08205	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D2E16_RS08220	COG0517	IMP dehydrogenase activity
D2E16_RS08250	COG0683	leucine binding
D2E16_RS08265	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D2E16_RS08270	COG0366	Alpha amylase catalytic
D2E16_RS08280	COG0395	ABC-type sugar transport system, permease component
D2E16_RS08285	COG1175	transmembrane transport
D2E16_RS08290	COG1653	transport
D2E16_RS08300	COG2207	Transcriptional regulator
D2E16_RS08305	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D2E16_RS08310	COG0626	cystathionine gamma-synthase activity
D2E16_RS08330	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D2E16_RS08335	COG2827	Endonuclease containing a URI domain
D2E16_RS08355	COG0640	Transcriptional regulator
D2E16_RS08360	COG0513	Belongs to the DEAD box helicase family
D2E16_RS08365	COG0823	Involved in the tonB-independent uptake of proteins
D2E16_RS08395	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D2E16_RS08405	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D2E16_RS08425	COG1181	Belongs to the D-alanine--D-alanine ligase family
D2E16_RS08430	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D2E16_RS08435	COG0768	penicillin binding
D2E16_RS08440	COG0488	(ABC) transporter
D2E16_RS08445	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D2E16_RS08465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D2E16_RS08470	COG0765	amino acid transport
D2E16_RS08475	COG0765	amino acid transport
D2E16_RS08485	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D2E16_RS08500	COG0438	transferase activity, transferring glycosyl groups
D2E16_RS08515	COG1609	Transcriptional regulator
D2E16_RS08525	COG0343	queuine tRNA-ribosyltransferase activity
D2E16_RS08535	COG1832	CoA-binding protein
D2E16_RS08545	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D2E16_RS08545	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D2E16_RS08630	COG1131	(ABC) transporter
D2E16_RS08660	COG0789	Transcriptional regulator
D2E16_RS08665	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D2E16_RS08670	COG2217	Heavy metal translocating P-type atpase
D2E16_RS08685	COG1063	alcohol dehydrogenase
D2E16_RS08700	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D2E16_RS08705	COG0557	exoribonuclease II activity
D2E16_RS08715	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D2E16_RS08720	COG2814	Major facilitator Superfamily
D2E16_RS08730	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D2E16_RS08740	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D2E16_RS08745	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D2E16_RS08755	COG1737	Transcriptional regulator
D2E16_RS08775	COG1011	Hydrolase
D2E16_RS08780	COG1132	(ABC) transporter
D2E16_RS08785	COG1132	(ABC) transporter
D2E16_RS08935	COG0740	serine-type endopeptidase activity
D2E16_RS08970	COG0582	viral genome integration into host DNA
D2E16_RS09085	COG3645	SOS response
D2E16_RS09090	COG4974	Belongs to the 'phage' integrase family
D2E16_RS09110	COG2177	Part of the ABC transporter FtsEX involved in
D2E16_RS09115	COG2884	Cell division ATP-binding protein ftsE
D2E16_RS09125	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D2E16_RS09165	COG1078	dGTPase activity
D2E16_RS09175	COG0149	triose-phosphate isomerase activity
D2E16_RS09180	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D2E16_RS09195	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D2E16_RS09200	COG0772	Belongs to the SEDS family
D2E16_RS09220	COG3859	Proton-coupled thiamine transporter YuaJ
D2E16_RS09230	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D2E16_RS09240	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D2E16_RS09250	COG0577	efflux transmembrane transporter activity
D2E16_RS09255	COG1136	(ABC) transporter
D2E16_RS09260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D2E16_RS09265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D2E16_RS09270	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D2E16_RS09275	COG1268	BioY protein
D2E16_RS09280	COG4443	Transcriptional Coactivator p15 (PC4)
D2E16_RS09290	COG0826	peptidase U32
D2E16_RS09305	COG0789	Transcriptional regulator
D2E16_RS09320	COG1227	inorganic diphosphatase activity
D2E16_RS09330	COG1733	regulation of RNA biosynthetic process
D2E16_RS09335	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D2E16_RS09355	COG2514	catechol 2,3-dioxygenase activity
D2E16_RS09360	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D2E16_RS09365	COG1253	flavin adenine dinucleotide binding
D2E16_RS09370	COG1119	ATPase activity
D2E16_RS09375	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D2E16_RS09395	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D2E16_RS09400	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D2E16_RS09405	COG0133	tryptophan synthase activity
D2E16_RS09420	COG4470	Protein conserved in bacteria
D2E16_RS09425	COG3480	Lon protease (S16) C-terminal proteolytic domain
D2E16_RS09430	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D2E16_RS09435	COG0742	ribosomal rna small subunit methyltransferase
D2E16_RS09445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D2E16_RS09450	COG4483	Protein conserved in bacteria
D2E16_RS09455	COG2197	response regulator
D2E16_RS09460	COG4585	Histidine kinase
D2E16_RS09465	COG0842	Transport permease protein
D2E16_RS09470	COG1131	(ABC) transporter
D2E16_RS09485	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D2E16_RS09495	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D2E16_RS09495	COG2755	lipolytic protein G-D-S-L family
D2E16_RS09500	COG4372	Transposase
D2E16_RS09520	COG0671	phosphoesterase, PA-phosphatase related
D2E16_RS09525	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
D2E16_RS09560	COG4372	Transposase
D2E16_RS09565	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D2E16_RS09570	COG1187	pseudouridine synthase activity
D2E16_RS09575	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D2E16_RS09580	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D2E16_RS09585	COG0582	viral genome integration into host DNA
D2E16_RS09605	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D2E16_RS09610	COG3763	UPF0154 protein
D2E16_RS09620	COG3579	cysteine-type endopeptidase activity
D2E16_RS09635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D2E16_RS09640	COG1254	Belongs to the acylphosphatase family
D2E16_RS09650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D2E16_RS09655	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D2E16_RS09660	COG2826	transposase and inactivated derivatives, IS30 family
D2E16_RS09675	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D2E16_RS09685	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D2E16_RS09700	COG1160	GTP binding
D2E16_RS09710	COG1484	DNA-dependent DNA replication
D2E16_RS09720	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D2E16_RS09725	COG0628	permease
D2E16_RS09730	COG0745	RESPONSE REGULATOR receiver
D2E16_RS09735	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D2E16_RS09745	COG0492	ferredoxin-NADP+ reductase activity
D2E16_RS09755	COG0513	Belongs to the DEAD box helicase family
D2E16_RS09765	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D2E16_RS09770	COG0768	penicillin binding
D2E16_RS09780	COG0275	rRNA processing
D2E16_RS09825	COG4939	FMN-binding domain protein
D2E16_RS09830	COG0142	geranyltranstransferase activity
D2E16_RS09835	COG1252	NADH dehydrogenase
D2E16_RS09845	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D2E16_RS09850	COG0569	domain protein
D2E16_RS09855	COG0534	Mate efflux family protein
D2E16_RS09870	COG0751	glycine-tRNA ligase activity
D2E16_RS09895	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D2E16_RS09900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D2E16_RS09905	COG1464	Belongs to the NlpA lipoprotein family
D2E16_RS09930	COG0444	Belongs to the ABC transporter superfamily
D2E16_RS09935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D2E16_RS09940	COG0601	transmembrane transport
D2E16_RS09950	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D2E16_RS09965	COG2252	PERMEase
D2E16_RS09970	COG0561	phosphatase activity
D2E16_RS09980	COG3715	PTS system
D2E16_RS09985	COG3716	PTS system mannose fructose sorbose family IID component
D2E16_RS10010	COG3177	Filamentation induced by cAMP protein fic
D2E16_RS10020	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D2E16_RS10035	COG1266	CAAX protease self-immunity
D2E16_RS10055	COG0439	Biotin carboxylase
D2E16_RS10075	COG1028	Short-chain dehydrogenase reductase Sdr
D2E16_RS10080	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D2E16_RS10085	COG2070	2-Nitropropane dioxygenase
D2E16_RS10095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D2E16_RS10105	COG1024	Enoyl-CoA hydratase
D2E16_RS10110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D2E16_RS10115	COG0527	aspartate kinase activity
D2E16_RS10120	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D2E16_RS10125	COG0736	holo-[acyl-carrier-protein] synthase activity
D2E16_RS10130	COG0653	protein targeting
D2E16_RS10145	COG1940	carbohydrate kinase activity
D2E16_RS10150	COG2190	(PTS) system
D2E16_RS10150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2E16_RS10150	COG1263	PTS System
D2E16_RS10155	COG1621	beta-fructofuranosidase activity
D2E16_RS10160	COG1609	Transcriptional regulator
D2E16_RS10165	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D2E16_RS10180	COG0006	proline dipeptidase activity
D2E16_RS10210	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D2E16_RS10225	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D2E16_RS10230	COG0629	single-stranded DNA binding
D2E16_RS10240	COG0095	Lipoate-protein ligase
D2E16_RS10250	COG0508	dehydrogenase complex catalyzes the overall conversion of
D2E16_RS10255	COG0022	dehydrogenase e1 component
D2E16_RS10255	COG0508	dehydrogenase complex catalyzes the overall conversion of
D2E16_RS10260	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D2E16_RS10265	COG2860	membrane
D2E16_RS10280	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D2E16_RS10285	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D2E16_RS10295	COG2740	Nucleic-acid-binding protein implicated in transcription termination
D2E16_RS10300	COG0195	Participates in both transcription termination and antitermination
D2E16_RS10310	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D2E16_RS10320	COG4473	ABC transporter
D2E16_RS10325	COG1131	(ABC) transporter
D2E16_RS10330	COG0537	adenosine 5'-monophosphoramidase activity
D2E16_RS10340	COG1316	TRANSCRIPTIONal
D2E16_RS10350	COG0802	atpase or kinase
D2E16_RS10355	COG1461	Dihydroxyacetone kinase
D2E16_RS10365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D2E16_RS10370	COG0601	transmembrane transport
D2E16_RS10375	COG4608	Belongs to the ABC transporter superfamily
D2E16_RS10390	COG1686	Belongs to the peptidase S11 family
D2E16_RS10405	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D2E16_RS10410	COG0719	Fe-S assembly protein
D2E16_RS10420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D2E16_RS10425	COG4862	establishment of competence for transformation
D2E16_RS10430	COG1968	undecaprenyl-diphosphatase activity
D2E16_RS10435	COG0765	amino acid transport
D2E16_RS10440	COG1126	abc transporter atp-binding protein
D2E16_RS10455	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D2E16_RS10460	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D2E16_RS10465	COG0440	acetolactate synthase activity
D2E16_RS10475	COG0463	Glycosyl transferase, family 2
D2E16_RS10490	COG0129	dihydroxy-acid dehydratase activity
D2E16_RS10495	COG1442	glycosyl transferase family 8
D2E16_RS10505	COG2151	metal-sulfur cluster biosynthetic enzyme
D2E16_RS10695	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D2E16_RS10715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D2E16_RS10740	COG3842	ATPase activity
D2E16_RS10750	COG4753	response regulator
D2E16_RS10750	COG2207	Transcriptional regulator
D2E16_RS10755	COG2972	Histidine kinase
D2E16_RS10765	COG1653	transport
D2E16_RS10770	COG0395	ABC-type sugar transport system, permease component
D2E16_RS10775	COG1175	transmembrane transport
D2E16_RS10780	COG2723	6-phospho-beta-galactosidase activity
D2E16_RS10800	COG0383	alpha-mannosidase activity
D2E16_RS10825	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
D2E16_RS10830	COG0215	cysteine-tRNA ligase activity
D2E16_RS10850	COG1045	serine acetyltransferase
D2E16_RS10855	COG1185	polyribonucleotide nucleotidyltransferase activity
D2E16_RS10860	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D2E16_RS10890	COG0464	growth
D2E16_RS10900	COG1174	glycine betaine transport
D2E16_RS10905	COG1125	glycine betaine transport
D2E16_RS10905	COG0517	IMP dehydrogenase activity
D2E16_RS10940	COG1733	regulation of RNA biosynthetic process
D2E16_RS10950	COG1187	pseudouridine synthase activity
D2E16_RS10970	COG0242	peptide deformylase activity
D2E16_RS10990	COG1136	(ABC) transporter
D2E16_RS11005	COG0066	3-isopropylmalate dehydratase activity
D2E16_RS11030	COG2309	aminopeptidase activity
D2E16_RS11040	COG2176	DNA-directed DNA polymerase activity
D2E16_RS11055	COG2376	Dihydroxyacetone kinase
D2E16_RS11065	COG2376	Dihydroxyacetone kinase
D2E16_RS11070	COG1461	Dihydroxyacetone kinase
D2E16_RS11075	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
D2E16_RS11080	COG0442	prolyl-tRNA aminoacylation
D2E16_RS11090	COG4589	Belongs to the CDS family
D2E16_RS11095	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D2E16_RS11100	COG1862	Preprotein translocase
D2E16_RS11110	COG2918	glutathione biosynthetic process
D2E16_RS11110	COG1181	Belongs to the D-alanine--D-alanine ligase family
D2E16_RS11120	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D2E16_RS11125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D2E16_RS11130	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D2E16_RS11135	COG0542	response to heat
D2E16_RS11140	COG4463	regulation of RNA biosynthetic process
D2E16_RS11155	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D2E16_RS11190	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D2E16_RS11195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D2E16_RS11200	COG0492	ferredoxin-NADP+ reductase activity
D2E16_RS11240	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D2E16_RS11260	COG1564	THIamine pyrophosphokinase
D2E16_RS11270	COG1162	GTPase activity
D2E16_RS11300	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D2E16_RS11305	COG1132	(ABC) transporter
D2E16_RS11335	COG4115	mRNA cleavage
D2E16_RS11370	COG0084	hydrolase, TatD family'
D2E16_RS11385	COG1847	R3H domain protein
D2E16_RS11395	COG0594	ribonuclease P activity
D2E16_RS11400	COG0165	Argininosuccinate lyase
D2E16_RS11405	COG0137	argininosuccinate synthase activity
D2E16_RS11415	COG2040	homocysteine
D2E16_RS11420	COG0833	amino acid
D2E16_RS11455	COG3764	Sortase (surface protein transpeptidase)
D2E16_RS11480	COG0756	dUTP diphosphatase activity
D2E16_RS11505	COG0577	efflux transmembrane transporter activity
D2E16_RS11505	COG1136	(ABC) transporter
D2E16_RS11530	COG2832	Protein of unknown function (DUF454)
D2E16_RS11540	COG0431	NADPH-dependent FMN reductase
D2E16_RS11540	COG1053	succinate dehydrogenase
D2E16_RS11540	COG3976	FMN-binding domain protein
D2E16_RS11550	COG1132	(ABC) transporter
D2E16_RS11555	COG1132	(ABC) transporter
D2E16_RS11565	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D2E16_RS11570	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D2E16_RS11575	COG0705	Rhomboid family
D2E16_RS11580	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D2E16_RS11585	COG1473	amidohydrolase
D2E16_RS11590	COG2171	N-acyltransferase activity
D2E16_RS11605	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D2E16_RS11635	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D2E16_RS11660	COG3623	hexulose-6-phosphate isomerase
D2E16_RS11690	COG1609	Transcriptional regulator
D2E16_RS11700	COG3942	CHAP domain
D2E16_RS11710	COG4667	esterase of the alpha-beta hydrolase superfamily
D2E16_RS11715	COG3590	peptidase
D2E16_RS11720	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D2E16_RS11725	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D2E16_RS11725	COG1321	iron dependent repressor
D2E16_RS11730	COG1121	(ABC) transporter
D2E16_RS11735	COG0803	Belongs to the bacterial solute-binding protein 9 family
D2E16_RS11805	COG3290	protein histidine kinase activity
D2E16_RS11830	COG1490	D-aminoacyl-tRNA deacylase activity
D2E16_RS11840	COG0737	Belongs to the 5'-nucleotidase family
D2E16_RS11845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D2E16_RS11855	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D2E16_RS11880	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D2E16_RS11910	COG1328	CTP reductase activity
D2E16_RS11935	COG0778	Nitroreductase
D2E16_RS11940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D2E16_RS11970	COG1438	arginine binding
D2E16_RS11975	COG0018	arginyl-trna synthetase
D2E16_RS12030	COG1640	4-alpha-glucanotransferase
D2E16_RS12035	COG2182	Extracellular solute-binding protein
D2E16_RS12040	COG1175	transmembrane transport
D2E16_RS12045	COG3833	ABC-type maltose transport systems, permease component
D2E16_RS12050	COG5521	maltodextrose utilization protein MalA
D2E16_RS12055	COG1609	Transcriptional regulator
D2E16_RS12060	COG1523	belongs to the glycosyl hydrolase 13 family
D2E16_RS12065	COG1780	Probably involved in ribonucleotide reductase function
D2E16_RS12070	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D2E16_RS12075	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D2E16_RS12080	COG2153	protein acetylation
D2E16_RS12085	COG4989	oxidoreductase activity
D2E16_RS12090	COG1216	Glycosyl transferase, family 2
D2E16_RS12095	COG1472	Belongs to the glycosyl hydrolase 3 family
D2E16_RS12140	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D2E16_RS12150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D2E16_RS12155	COG0785	Cytochrome C biogenesis protein
D2E16_RS12170	COG0305	Participates in initiation and elongation during chromosome replication
D2E16_RS12175	COG0359	binds to the 23S rRNA
D2E16_RS12185	COG0445	tRNA wobble uridine modification
D2E16_RS12190	COG0494	nUDIX hydrolase
D2E16_RS12200	COG1051	belongs to the nudix hydrolase family
D2E16_RS12205	COG1733	regulation of RNA biosynthetic process
D2E16_RS12215	COG0482	sulfurtransferase activity
D2E16_RS12220	COG1760	l-serine dehydratase
D2E16_RS12225	COG1760	l-serine dehydratase
D2E16_RS12245	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D2E16_RS12250	COG1122	ATPase activity
D2E16_RS12255	COG1122	ATPase activity
D2E16_RS12260	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D2E16_RS12270	COG0612	Peptidase, M16
D2E16_RS12275	COG0612	Peptidase, M16
D2E16_RS12345	COG0582	viral genome integration into host DNA
D2E16_RS12355	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D2E16_RS12360	COG0516	GMP reductase activity
D2E16_RS12360	COG0517	IMP dehydrogenase activity
D2E16_RS12370	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D2E16_RS12375	COG0488	(ABC) transporter
D2E16_RS12405	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D2E16_RS12410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D2E16_RS12415	COG1475	DNA binding