locus-tag	class	description
I5V48_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I5V48_RS00010	COG0592	DNA-directed DNA polymerase activity
I5V48_RS00030	COG0012	GTP binding
I5V48_RS00035	COG0193	aminoacyl-tRNA hydrolase activity
I5V48_RS00040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I5V48_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I5V48_RS00060	COG0037	tRNA processing
I5V48_RS00070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I5V48_RS00180	COG1792	Involved in formation and maintenance of cell shape
I5V48_RS00195	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I5V48_RS00200	COG0436	Aminotransferase
I5V48_RS00205	COG1381	Involved in DNA repair and RecF pathway recombination
I5V48_RS00210	COG0416	fatty acid biosynthetic process
I5V48_RS00215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I5V48_RS00225	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I5V48_RS00240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I5V48_RS00250	COG0138	bifunctional purine biosynthesis protein purh
I5V48_RS00265	COG3583	domain protein
I5V48_RS00275	COG0151	Belongs to the GarS family
I5V48_RS00280	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I5V48_RS00300	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I5V48_RS00320	COG1131	(ABC) transporter
I5V48_RS00330	COG1132	(ABC) transporter
I5V48_RS00335	COG0789	Transcriptional regulator
I5V48_RS00340	COG2255	four-way junction helicase activity
I5V48_RS00350	COG0546	phosphoglycolate phosphatase activity
I5V48_RS00360	COG0285	dihydrofolate synthase activity
I5V48_RS00370	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I5V48_RS00375	COG0632	four-way junction helicase activity
I5V48_RS00380	COG0519	Catalyzes the synthesis of GMP from XMP
I5V48_RS00395	COG1393	Belongs to the ArsC family
I5V48_RS00400	COG4472	Bacterial protein of unknown function (DUF965)
I5V48_RS00405	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I5V48_RS00410	COG3906	Belongs to the UPF0473 family
I5V48_RS00425	COG0051	transcription antitermination factor activity, RNA binding
I5V48_RS00430	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I5V48_RS00435	COG0088	Forms part of the polypeptide exit tunnel
I5V48_RS00440	COG0089	rRNA binding
I5V48_RS00445	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I5V48_RS00450	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I5V48_RS00455	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I5V48_RS00460	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I5V48_RS00465	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I5V48_RS00470	COG0255	Belongs to the universal ribosomal protein uL29 family
I5V48_RS00475	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I5V48_RS00480	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I5V48_RS00485	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I5V48_RS00490	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I5V48_RS00495	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I5V48_RS00500	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I5V48_RS00505	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I5V48_RS00510	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I5V48_RS00515	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I5V48_RS00520	COG1841	ribosomal large subunit assembly
I5V48_RS00530	COG0201	protein transport
I5V48_RS00535	COG0563	adenylate kinase activity
I5V48_RS00540	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I5V48_RS00545	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I5V48_RS00550	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I5V48_RS00560	COG0202	RNA polymerase activity
I5V48_RS00670	COG1121	(ABC) transporter
I5V48_RS00675	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5V48_RS00680	COG0803	Belongs to the bacterial solute-binding protein 9 family
I5V48_RS00680	COG3443	Belongs to the bacterial solute-binding protein 9 family
I5V48_RS00710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5V48_RS00715	COG0085	RNA polymerase activity
I5V48_RS00720	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I5V48_RS00735	COG1619	proteins homologs of microcin C7 resistance protein MccF
I5V48_RS00740	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5V48_RS00745	COG1459	type II secretion system
I5V48_RS00750	COG4537	Required for transformation and DNA binding
I5V48_RS00780	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I5V48_RS00790	COG0285	dihydrofolate synthase activity
I5V48_RS00805	COG1363	Peptidase, m42
I5V48_RS00820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5V48_RS00830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5V48_RS00860	COG0049	tRNA binding
I5V48_RS00865	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I5V48_RS00880	COG0126	phosphoglycerate kinase activity
I5V48_RS00890	COG0789	Transcriptional regulator
I5V48_RS00895	COG0174	glutamine synthetase
I5V48_RS00905	COG5503	Protein of unknown function (DUF1447)
I5V48_RS00910	COG1396	sequence-specific DNA binding
I5V48_RS00915	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I5V48_RS00920	COG1214	PFAM Peptidase M22, glycoprotease
I5V48_RS00930	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I5V48_RS00975	COG2855	membrane
I5V48_RS00985	COG1131	(ABC) transporter
I5V48_RS00995	COG2081	HI0933 family
I5V48_RS01015	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5V48_RS01030	COG3959	Transketolase, thiamine diphosphate binding domain
I5V48_RS01035	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I5V48_RS01045	COG0584	glycerophosphoryl diester phosphodiesterase
I5V48_RS01050	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I5V48_RS01055	COG2222	sugar isomerase
I5V48_RS01080	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I5V48_RS01085	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I5V48_RS01105	COG3177	Filamentation induced by cAMP protein fic
I5V48_RS01115	COG1882	Formate acetyltransferase
I5V48_RS01120	COG0366	Alpha amylase catalytic
I5V48_RS01120	COG0366	Alpha amylase catalytic
I5V48_RS01135	COG1959	2 iron, 2 sulfur cluster binding
I5V48_RS01140	COG2910	NAD(P)H-binding
I5V48_RS01170	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I5V48_RS01175	COG0681	Belongs to the peptidase S26 family
I5V48_RS01200	COG0366	Alpha amylase catalytic
I5V48_RS01205	COG1263	PTS System
I5V48_RS01205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5V48_RS01210	COG2188	Transcriptional regulator
I5V48_RS01225	COG1193	negative regulation of DNA recombination
I5V48_RS01235	COG3118	belongs to the thioredoxin family
I5V48_RS01240	COG1021	2,3-dihydroxybenzoate-AMP ligase
I5V48_RS01245	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I5V48_RS01245	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I5V48_RS01255	COG1136	(ABC) transporter
I5V48_RS01260	COG1115	amino acid carrier protein
I5V48_RS01270	COG0668	transmembrane transport
I5V48_RS01280	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I5V48_RS01285	COG0167	dihydroorotate dehydrogenase activity
I5V48_RS01290	COG2843	Capsule synthesis protein
I5V48_RS01310	COG0561	phosphatase activity
I5V48_RS01325	COG1131	(ABC) transporter
I5V48_RS01330	COG1309	transcriptional regulator
I5V48_RS01335	COG1511	domain protein
I5V48_RS01360	COG1346	cytolysis
I5V48_RS01365	COG2116	formate transmembrane transporter activity
I5V48_RS01370	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I5V48_RS01380	COG0494	nUDIX hydrolase
I5V48_RS01385	COG1396	sequence-specific DNA binding
I5V48_RS01390	COG0542	response to heat
I5V48_RS01410	COG1349	DNA-binding transcription factor activity
I5V48_RS01415	COG0698	ribose 5-phosphate isomerase
I5V48_RS01420	COG0698	ribose 5-phosphate isomerase
I5V48_RS01425	COG1105	Belongs to the carbohydrate kinase PfkB family
I5V48_RS01430	COG3684	Belongs to the aldolase LacD family
I5V48_RS01435	COG3711	transcriptional antiterminator
I5V48_RS01445	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5V48_RS01445	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5V48_RS01460	COG1408	metallophosphoesterase
I5V48_RS01490	COG2946	Replication initiation factor
I5V48_RS01505	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I5V48_RS01510	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I5V48_RS01530	COG0124	histidyl-tRNA synthetase
I5V48_RS01535	COG1064	alcohol dehydrogenase
I5V48_RS01540	COG1454	alcohol dehydrogenase
I5V48_RS01540	COG1012	belongs to the aldehyde dehydrogenase family
I5V48_RS01550	COG4988	ABC transporter
I5V48_RS01555	COG1132	(ABC) transporter
I5V48_RS01570	COG1129	ABC transporter
I5V48_RS01575	COG0534	Mate efflux family protein
I5V48_RS01580	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I5V48_RS01595	COG1304	FMN binding
I5V48_RS01645	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I5V48_RS01650	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I5V48_RS01665	COG3830	Belongs to the UPF0237 family
I5V48_RS01670	COG2848	UPF0210 protein
I5V48_RS01675	COG0588	phosphoglycerate mutase activity
I5V48_RS01690	COG1420	regulation of RNA biosynthetic process
I5V48_RS01695	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I5V48_RS01700	COG0443	Heat shock 70 kDa protein
I5V48_RS01705	COG0484	heat shock protein binding
I5V48_RS01710	COG0095	Lipoate-protein ligase
I5V48_RS01720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5V48_RS01750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5V48_RS01755	COG0765	amino acid transport
I5V48_RS01775	COG3655	Transcriptional regulator
I5V48_RS01785	COG2217	Heavy metal translocating P-type atpase
I5V48_RS01800	COG0351	phosphomethylpyrimidine kinase
I5V48_RS01810	COG4475	Protein of unknown function (DUF436)
I5V48_RS01835	COG4221	oxidoreductase activity
I5V48_RS01840	COG0446	pyridine nucleotide-disulphide oxidoreductase
I5V48_RS01840	COG1902	pentaerythritol trinitrate reductase activity
I5V48_RS01860	COG2910	NAD(P)H-binding
I5V48_RS01865	COG1959	2 iron, 2 sulfur cluster binding
I5V48_RS01890	COG0544	peptidyl-prolyl cis-trans isomerase activity
I5V48_RS01905	COG3343	RNA polymerase activity
I5V48_RS01910	COG0504	CTP synthase activity
I5V48_RS01920	COG0191	fructose-bisphosphate aldolase activity
I5V48_RS01925	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I5V48_RS01965	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I5V48_RS01990	COG0436	Aminotransferase
I5V48_RS01995	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I5V48_RS02000	COG1335	isochorismatase
I5V48_RS02010	COG2860	membrane
I5V48_RS02015	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I5V48_RS02020	COG0022	dehydrogenase e1 component
I5V48_RS02020	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5V48_RS02025	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5V48_RS02035	COG0095	Lipoate-protein ligase
I5V48_RS02045	COG0629	single-stranded DNA binding
I5V48_RS02050	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I5V48_RS02070	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I5V48_RS02120	COG0006	proline dipeptidase activity
I5V48_RS02135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I5V48_RS02140	COG1609	Transcriptional regulator
I5V48_RS02145	COG1621	beta-fructofuranosidase activity
I5V48_RS02150	COG1263	PTS System
I5V48_RS02150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5V48_RS02150	COG2190	(PTS) system
I5V48_RS02155	COG1940	carbohydrate kinase activity
I5V48_RS02175	COG0582	viral genome integration into host DNA
I5V48_RS02180	COG3645	SOS response
I5V48_RS02285	COG3935	DnaD domain protein
I5V48_RS02310	COG0863	Belongs to the N(4) N(6)-methyltransferase family
I5V48_RS02360	COG0582	viral genome integration into host DNA
I5V48_RS02490	COG0653	protein targeting
I5V48_RS02495	COG0736	holo-[acyl-carrier-protein] synthase activity
I5V48_RS02500	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I5V48_RS02505	COG0527	aspartate kinase activity
I5V48_RS02515	COG1024	Enoyl-CoA hydratase
I5V48_RS02525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I5V48_RS02540	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I5V48_RS02545	COG1028	Short-chain dehydrogenase reductase Sdr
I5V48_RS02565	COG0439	Biotin carboxylase
I5V48_RS02585	COG1266	CAAX protease self-immunity
I5V48_RS02590	COG1266	CAAX protease self-immunity
I5V48_RS02605	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I5V48_RS02615	COG3177	Filamentation induced by cAMP protein fic
I5V48_RS02640	COG3716	PTS system mannose fructose sorbose family IID component
I5V48_RS02645	COG3715	PTS system
I5V48_RS02655	COG0561	phosphatase activity
I5V48_RS02660	COG2252	PERMEase
I5V48_RS02670	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I5V48_RS02675	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I5V48_RS02685	COG0601	transmembrane transport
I5V48_RS02690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5V48_RS02695	COG0444	Belongs to the ABC transporter superfamily
I5V48_RS02705	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I5V48_RS02715	COG1464	Belongs to the NlpA lipoprotein family
I5V48_RS02725	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I5V48_RS02750	COG0751	glycine-tRNA ligase activity
I5V48_RS02765	COG0534	Mate efflux family protein
I5V48_RS02770	COG0569	domain protein
I5V48_RS02775	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I5V48_RS02785	COG1252	NADH dehydrogenase
I5V48_RS02790	COG0142	geranyltranstransferase activity
I5V48_RS02795	COG4939	FMN-binding domain protein
I5V48_RS02840	COG0275	rRNA processing
I5V48_RS02850	COG0768	penicillin binding
I5V48_RS02855	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I5V48_RS02865	COG0513	Belongs to the DEAD box helicase family
I5V48_RS02875	COG0492	ferredoxin-NADP+ reductase activity
I5V48_RS02885	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I5V48_RS02890	COG0745	RESPONSE REGULATOR receiver
I5V48_RS02895	COG0628	permease
I5V48_RS02900	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I5V48_RS02910	COG1484	DNA-dependent DNA replication
I5V48_RS02920	COG1160	GTP binding
I5V48_RS02930	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I5V48_RS02940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I5V48_RS02950	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I5V48_RS02955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I5V48_RS02965	COG1254	Belongs to the acylphosphatase family
I5V48_RS02970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5V48_RS02985	COG3579	cysteine-type endopeptidase activity
I5V48_RS02995	COG3763	UPF0154 protein
I5V48_RS03000	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I5V48_RS03020	COG0582	viral genome integration into host DNA
I5V48_RS03025	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I5V48_RS03030	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I5V48_RS03035	COG1187	pseudouridine synthase activity
I5V48_RS03040	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I5V48_RS03055	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I5V48_RS03060	COG0671	phosphoesterase, PA-phosphatase related
I5V48_RS03065	COG2755	lipolytic protein G-D-S-L family
I5V48_RS03065	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I5V48_RS03090	COG1131	(ABC) transporter
I5V48_RS03095	COG0842	Transport permease protein
I5V48_RS03100	COG4585	Histidine kinase
I5V48_RS03105	COG2197	response regulator
I5V48_RS03110	COG4483	Protein conserved in bacteria
I5V48_RS03115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5V48_RS03125	COG0742	ribosomal rna small subunit methyltransferase
I5V48_RS03130	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I5V48_RS03135	COG3480	Lon protease (S16) C-terminal proteolytic domain
I5V48_RS03140	COG4470	Protein conserved in bacteria
I5V48_RS03155	COG0133	tryptophan synthase activity
I5V48_RS03160	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I5V48_RS03165	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I5V48_RS03185	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I5V48_RS03190	COG1119	ATPase activity
I5V48_RS03195	COG1253	flavin adenine dinucleotide binding
I5V48_RS03200	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I5V48_RS03205	COG1472	Belongs to the glycosyl hydrolase 3 family
I5V48_RS03215	COG2514	catechol 2,3-dioxygenase activity
I5V48_RS03235	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I5V48_RS03240	COG1733	regulation of RNA biosynthetic process
I5V48_RS03250	COG1227	inorganic diphosphatase activity
I5V48_RS03260	COG0789	Transcriptional regulator
I5V48_RS03275	COG0826	peptidase U32
I5V48_RS03290	COG4443	Transcriptional Coactivator p15 (PC4)
I5V48_RS03295	COG1268	BioY protein
I5V48_RS03300	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
I5V48_RS03305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5V48_RS03310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5V48_RS03315	COG1136	(ABC) transporter
I5V48_RS03320	COG0577	efflux transmembrane transporter activity
I5V48_RS03330	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I5V48_RS03340	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I5V48_RS03350	COG3859	Proton-coupled thiamine transporter YuaJ
I5V48_RS03370	COG0772	Belongs to the SEDS family
I5V48_RS03375	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I5V48_RS03390	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I5V48_RS03395	COG0149	triose-phosphate isomerase activity
I5V48_RS03405	COG1078	dGTPase activity
I5V48_RS03440	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I5V48_RS03450	COG2884	Cell division ATP-binding protein ftsE
I5V48_RS03455	COG2177	Part of the ABC transporter FtsEX involved in
I5V48_RS03475	COG1132	(ABC) transporter
I5V48_RS03480	COG1132	(ABC) transporter
I5V48_RS03485	COG1011	Hydrolase
I5V48_RS03505	COG1737	Transcriptional regulator
I5V48_RS03515	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I5V48_RS03520	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I5V48_RS03525	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I5V48_RS03535	COG2814	Major facilitator Superfamily
I5V48_RS03550	COG0557	exoribonuclease II activity
I5V48_RS03555	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I5V48_RS03570	COG1063	alcohol dehydrogenase
I5V48_RS03585	COG2217	Heavy metal translocating P-type atpase
I5V48_RS03595	COG0110	maltose O-acetyltransferase activity
I5V48_RS03600	COG0583	DNA-binding transcription factor activity
I5V48_RS03605	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I5V48_RS03615	COG1131	(ABC) transporter
I5V48_RS03635	COG1136	(ABC) transporter
I5V48_RS03650	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I5V48_RS03650	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I5V48_RS03660	COG1832	CoA-binding protein
I5V48_RS03675	COG0343	queuine tRNA-ribosyltransferase activity
I5V48_RS03695	COG1940	carbohydrate kinase activity
I5V48_RS03700	COG2115	Belongs to the xylose isomerase family
I5V48_RS03705	COG1070	Carbohydrate kinase
I5V48_RS03720	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5V48_RS03725	COG3715	PTS system
I5V48_RS03730	COG3716	PTS system mannose fructose sorbose family IID component
I5V48_RS03750	COG1609	Transcriptional regulator
I5V48_RS03765	COG0438	transferase activity, transferring glycosyl groups
I5V48_RS03780	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I5V48_RS03785	COG0765	amino acid transport
I5V48_RS03790	COG0765	amino acid transport
I5V48_RS03795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5V48_RS03805	COG0745	RESPONSE REGULATOR receiver
I5V48_RS03815	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I5V48_RS03820	COG0488	(ABC) transporter
I5V48_RS03825	COG0768	penicillin binding
I5V48_RS03830	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I5V48_RS03835	COG1181	Belongs to the D-alanine--D-alanine ligase family
I5V48_RS03855	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I5V48_RS03865	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I5V48_RS03880	COG1131	(ABC) transporter
I5V48_RS03900	COG0513	Belongs to the DEAD box helicase family
I5V48_RS03905	COG0640	Transcriptional regulator
I5V48_RS03925	COG2827	Endonuclease containing a URI domain
I5V48_RS03930	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I5V48_RS03950	COG0626	cystathionine gamma-synthase activity
I5V48_RS03955	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I5V48_RS03960	COG2207	Transcriptional regulator
I5V48_RS03970	COG1653	transport
I5V48_RS03975	COG1175	transmembrane transport
I5V48_RS03980	COG0395	ABC-type sugar transport system, permease component
I5V48_RS03990	COG0366	Alpha amylase catalytic
I5V48_RS03995	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I5V48_RS04010	COG0683	leucine binding
I5V48_RS04045	COG0517	IMP dehydrogenase activity
I5V48_RS04060	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I5V48_RS04065	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I5V48_RS04070	COG0470	DNA polymerase III
I5V48_RS04075	COG4467	Involved in initiation control of chromosome replication
I5V48_RS04085	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I5V48_RS04095	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5V48_RS04105	COG1393	Belongs to the ArsC family
I5V48_RS04145	COG0708	Exodeoxyribonuclease III
I5V48_RS04155	COG0531	amino acid
I5V48_RS04205	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5V48_RS04205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5V48_RS04230	COG4122	O-methyltransferase activity
I5V48_RS04235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5V48_RS04245	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I5V48_RS04265	COG1476	TRANSCRIPTIONal
I5V48_RS04305	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5V48_RS04310	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5V48_RS04315	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I5V48_RS04320	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I5V48_RS04325	COG0372	Belongs to the citrate synthase family
I5V48_RS04330	COG0538	isocitrate dehydrogenase activity
I5V48_RS04335	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5V48_RS04345	COG1012	belongs to the aldehyde dehydrogenase family
I5V48_RS04380	COG1196	nuclear chromosome segregation
I5V48_RS04385	COG0561	phosphatase activity
I5V48_RS04390	COG0561	phosphatase activity
I5V48_RS04395	COG0552	protein localization to endoplasmic reticulum
I5V48_RS04410	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I5V48_RS04415	COG3689	TIGRFAM TIGR03943 family protein
I5V48_RS04420	COG0701	Predicted permease
I5V48_RS04435	COG1597	lipid kinase activity
I5V48_RS04445	COG0356	it plays a direct role in the translocation of protons across the membrane
I5V48_RS04450	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I5V48_RS04455	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I5V48_RS04460	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I5V48_RS04465	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I5V48_RS04470	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I5V48_RS04475	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I5V48_RS04485	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I5V48_RS04500	COG2211	Major facilitator Superfamily
I5V48_RS04510	COG3250	beta-galactosidase activity
I5V48_RS04520	COG0800	Aldolase
I5V48_RS04530	COG1312	Catalyzes the dehydration of D-mannonate
I5V48_RS04535	COG1028	Short-chain dehydrogenase reductase Sdr
I5V48_RS04565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5V48_RS04565	COG0072	phenylalanine-tRNA ligase activity
I5V48_RS04590	COG1051	belongs to the nudix hydrolase family
I5V48_RS04595	COG0302	gtp cyclohydrolase
I5V48_RS04615	COG2610	gluconate transmembrane transporter activity
I5V48_RS04620	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I5V48_RS04625	COG2807	transmembrane transport
I5V48_RS04635	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I5V48_RS04640	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I5V48_RS04650	COG1234	tRNA 3'-trailer cleavage
I5V48_RS04655	COG0300	oxidoreductase activity
I5V48_RS04665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5V48_RS04670	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I5V48_RS04670	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I5V48_RS04680	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I5V48_RS04695	COG2384	SAM-dependent methyltransferase
I5V48_RS04700	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I5V48_RS04710	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I5V48_RS04720	COG0135	phosphoribosylanthranilate isomerase activity
I5V48_RS04725	COG1088	dTDP-glucose 4,6-dehydratase activity
I5V48_RS04730	COG1091	dTDP-4-dehydrorhamnose reductase activity
I5V48_RS04760	COG1442	glycosyl transferase family 8
I5V48_RS04760	COG1216	Glycosyl transferase, family 2
I5V48_RS04790	COG1442	glycosyl transferase family 8
I5V48_RS04795	COG1442	glycosyl transferase family 8
I5V48_RS04795	COG1216	Glycosyl transferase, family 2
I5V48_RS04810	COG1216	Glycosyl transferase, family 2
I5V48_RS04850	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I5V48_RS04860	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I5V48_RS04875	COG1368	sulfuric ester hydrolase activity
I5V48_RS04880	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I5V48_RS04885	COG0710	3-dehydroquinate dehydratase activity
I5V48_RS04890	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I5V48_RS04895	COG0287	Prephenate dehydrogenase
I5V48_RS04900	COG3679	Belongs to the UPF0342 family
I5V48_RS04910	COG3684	Belongs to the aldolase LacD family
I5V48_RS04925	COG4120	Belongs to the binding-protein-dependent transport system permease family
I5V48_RS04930	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5V48_RS04930	COG1116	anion transmembrane transporter activity
I5V48_RS04945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5V48_RS04950	COG0657	acetylesterase activity
I5V48_RS04950	COG2755	lipolytic protein G-D-S-L family
I5V48_RS04960	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I5V48_RS04965	COG2213	PTS system mannitol-specific
I5V48_RS04970	COG3711	transcriptional antiterminator
I5V48_RS04975	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5V48_RS04980	COG0246	Mannitol dehydrogenase
I5V48_RS04985	COG0765	amino acid transport
I5V48_RS04990	COG1126	abc transporter atp-binding protein
I5V48_RS04995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5V48_RS05000	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I5V48_RS05015	COG1846	Transcriptional regulator
I5V48_RS05020	COG3759	membrane
I5V48_RS05055	COG2195	Cleaves the N-terminal amino acid of tripeptides
I5V48_RS05060	COG0561	phosphatase activity
I5V48_RS05080	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I5V48_RS05090	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I5V48_RS05095	COG0196	riboflavin kinase activity
I5V48_RS05100	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I5V48_RS05105	COG1393	Belongs to the ArsC family
I5V48_RS05110	COG4476	Belongs to the UPF0223 family
I5V48_RS05115	COG0483	inositol monophosphate 1-phosphatase activity
I5V48_RS05120	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I5V48_RS05120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I5V48_RS05130	COG0573	inorganic phosphate transmembrane transporter activity
I5V48_RS05135	COG0581	inorganic phosphate transmembrane transporter activity
I5V48_RS05140	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I5V48_RS05145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I5V48_RS05160	COG0745	RESPONSE REGULATOR receiver
I5V48_RS05165	COG5002	protein histidine kinase activity
I5V48_RS05175	COG0268	Binds directly to 16S ribosomal RNA
I5V48_RS05180	COG1072	(Pantothenic acid kinase))
I5V48_RS05185	COG2813	Specifically methylates the guanine in position
I5V48_RS05190	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I5V48_RS05200	COG0295	cytidine deaminase activity
I5V48_RS05205	COG1744	ABC transporter substrate-binding protein PnrA-like
I5V48_RS05210	COG3845	ABC transporter
I5V48_RS05215	COG4603	Belongs to the binding-protein-dependent transport system permease family
I5V48_RS05220	COG1079	Belongs to the binding-protein-dependent transport system permease family
I5V48_RS05225	COG0039	L-malate dehydrogenase activity
I5V48_RS05230	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I5V48_RS05235	COG3764	Sortase (surface protein transpeptidase)
I5V48_RS05245	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I5V48_RS05250	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I5V48_RS05265	COG1104	cysteine desulfurase activity
I5V48_RS05275	COG4116	CYTH
I5V48_RS05325	COG3561	AntA/AntB antirepressor
I5V48_RS05445	COG1475	DNA binding
I5V48_RS05575	COG5632	N-Acetylmuramoyl-L-alanine amidase
I5V48_RS05575	COG1388	LysM domain
I5V48_RS05575	COG3409	Peptidoglycan-binding domain 1 protein
I5V48_RS05585	COG2357	RelA SpoT domain protein
I5V48_RS05590	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I5V48_RS05595	COG0564	pseudouridine synthase activity
I5V48_RS05600	COG0280	phosphate acetyltransferase
I5V48_RS05605	COG1132	(ABC) transporter
I5V48_RS05610	COG1132	(ABC) transporter
I5V48_RS05620	COG1194	a g-specific adenine glycosylase
I5V48_RS05625	COG1396	sequence-specific DNA binding
I5V48_RS05635	COG1454	alcohol dehydrogenase
I5V48_RS05640	COG2873	o-acetylhomoserine
I5V48_RS05645	COG0488	(ABC) transporter
I5V48_RS05650	COG0456	acetyltransferase
I5V48_RS05655	COG1126	abc transporter atp-binding protein
I5V48_RS05695	COG0270	DNA (cytosine-5-)-methyltransferase activity
I5V48_RS05805	COG4443	Transcriptional Coactivator p15 (PC4)
I5V48_RS05840	COG1192	Involved in chromosome partitioning
I5V48_RS05915	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I5V48_RS05950	COG3843	relaxase mobilization nuclease domain protein
I5V48_RS05985	COG1136	(ABC) transporter
I5V48_RS06000	COG2197	response regulator
I5V48_RS06005	COG1396	sequence-specific DNA binding
I5V48_RS06035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5V48_RS06040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5V48_RS06050	COG0297	glycogen (starch) synthase activity
I5V48_RS06060	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I5V48_RS06075	COG0167	dihydroorotate dehydrogenase activity
I5V48_RS06080	COG0284	orotidine-5'-phosphate decarboxylase activity
I5V48_RS06095	COG0463	Glycosyl transferase, family 2
I5V48_RS06100	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I5V48_RS06110	COG0737	Belongs to the 5'-nucleotidase family
I5V48_RS06130	COG1737	Transcriptional regulator
I5V48_RS06150	COG1175	transmembrane transport
I5V48_RS06160	COG4409	exo-alpha-(2->6)-sialidase activity
I5V48_RS06165	COG0673	inositol 2-dehydrogenase activity
I5V48_RS06170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I5V48_RS06180	COG3458	cephalosporin-C deacetylase activity
I5V48_RS06200	COG1070	Carbohydrate kinase
I5V48_RS06220	COG1175	transmembrane transport
I5V48_RS06225	COG0395	ABC-type sugar transport system, permease component
I5V48_RS06260	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I5V48_RS06265	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I5V48_RS06275	COG1272	protein, Hemolysin III
I5V48_RS06285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5V48_RS06285	COG0425	Belongs to the sulfur carrier protein TusA family
I5V48_RS06290	COG0110	maltose O-acetyltransferase activity
I5V48_RS06295	COG0758	DNA mediated transformation
I5V48_RS06300	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I5V48_RS06305	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I5V48_RS06310	COG0222	ribosome binding
I5V48_RS06315	COG0647	UMP catabolic process
I5V48_RS06320	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I5V48_RS06325	COG2382	esterase
I5V48_RS06355	COG1136	(ABC) transporter
I5V48_RS06375	COG0745	RESPONSE REGULATOR receiver
I5V48_RS06380	COG5002	protein histidine kinase activity
I5V48_RS06400	COG4974	Belongs to the 'phage' integrase family
I5V48_RS06455	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I5V48_RS06460	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I5V48_RS06465	COG2188	Transcriptional regulator
I5V48_RS06475	COG4268	DNA restriction-modification system
I5V48_RS06480	COG1401	restriction endodeoxyribonuclease activity
I5V48_RS06505	COG4221	oxidoreductase activity
I5V48_RS06510	COG0741	lytic transglycosylase activity
I5V48_RS06520	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I5V48_RS06530	COG0009	L-threonylcarbamoyladenylate synthase
I5V48_RS06535	COG2890	protein-(glutamine-N5) methyltransferase activity
I5V48_RS06540	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I5V48_RS06555	COG0481	GTPase activity
I5V48_RS06570	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I5V48_RS06575	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I5V48_RS06580	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I5V48_RS06595	COG1940	carbohydrate kinase activity
I5V48_RS06605	COG0488	(ABC) transporter
I5V48_RS06610	COG0617	tRNA 3'-terminal CCA addition
I5V48_RS06615	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I5V48_RS06620	COG1307	EDD domain protein, DegV family
I5V48_RS06630	COG3583	domain protein
I5V48_RS06635	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5V48_RS06635	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5V48_RS06635	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5V48_RS06640	COG1105	Belongs to the carbohydrate kinase PfkB family
I5V48_RS06645	COG1349	DNA-binding transcription factor activity
I5V48_RS06655	COG0336	Belongs to the RNA methyltransferase TrmD family
I5V48_RS06660	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I5V48_RS06665	COG0534	Mate efflux family protein
I5V48_RS06675	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I5V48_RS06680	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I5V48_RS06695	COG0038	chloride channel
I5V48_RS06705	COG1177	transmembrane transport
I5V48_RS06710	COG1176	ABC-type spermidine putrescine transport system, permease component I
I5V48_RS06715	COG3842	ATPase activity
I5V48_RS06720	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I5V48_RS06725	COG0083	homoserine kinase activity
I5V48_RS06730	COG0460	homoserine dehydrogenase
I5V48_RS06740	COG1132	(ABC) transporter
I5V48_RS06755	COG0228	four-way junction DNA binding
I5V48_RS06765	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I5V48_RS06770	COG2136	Putative SAM-dependent methyltransferase
I5V48_RS06770	COG2521	methyltransferase
I5V48_RS06780	COG0505	Belongs to the CarA family
I5V48_RS06785	COG0540	Belongs to the ATCase OTCase family
I5V48_RS06790	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I5V48_RS06800	COG2824	Alkylphosphonate utilization operon protein PhnA
I5V48_RS06805	COG0564	pseudouridine synthase activity
I5V48_RS06835	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I5V48_RS06840	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I5V48_RS06850	COG1114	Component of the transport system for branched-chain amino acids
I5V48_RS06855	COG0301	tRNA thio-modification
I5V48_RS06860	COG1104	cysteine desulfurase activity
I5V48_RS06885	COG0539	negative regulation of cytoplasmic translation
I5V48_RS06905	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I5V48_RS06910	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I5V48_RS06930	COG2184	nucleotidyltransferase activity
I5V48_RS06935	COG0187	DNA topoisomerase II activity
I5V48_RS06950	COG1074	ATP-dependent DNA helicase activity
I5V48_RS06955	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I5V48_RS06995	COG1131	(ABC) transporter
I5V48_RS07020	COG1011	Hydrolase
I5V48_RS07030	COG0210	DNA helicase
I5V48_RS07035	COG3177	Filamentation induced by cAMP protein fic
I5V48_RS07050	COG1164	Oligoendopeptidase f
I5V48_RS07060	COG0346	lactoylglutathione lyase activity
I5V48_RS07065	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I5V48_RS07070	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I5V48_RS07075	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I5V48_RS07085	COG0446	pyridine nucleotide-disulphide oxidoreductase
I5V48_RS07090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I5V48_RS07095	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I5V48_RS07120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5V48_RS07130	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I5V48_RS07140	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I5V48_RS07145	COG4684	Psort location CytoplasmicMembrane, score
I5V48_RS07150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I5V48_RS07160	COG0454	-acetyltransferase
I5V48_RS07230	COG3620	sequence-specific DNA binding
I5V48_RS07240	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I5V48_RS07285	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I5V48_RS07295	COG0077	Prephenate dehydratase
I5V48_RS07300	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I5V48_RS07310	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I5V48_RS07315	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I5V48_RS07320	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I5V48_RS07325	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I5V48_RS07340	COG0469	pyruvate kinase activity
I5V48_RS07345	COG0205	6-phosphofructokinase activity
I5V48_RS07355	COG2188	Transcriptional regulator
I5V48_RS07360	COG1131	(ABC) transporter
I5V48_RS07370	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I5V48_RS07420	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I5V48_RS07425	COG1982	Orn Lys Arg decarboxylase major
I5V48_RS07430	COG2151	metal-sulfur cluster biosynthetic enzyme
I5V48_RS07435	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I5V48_RS07440	COG0358	DNA primase activity
I5V48_RS07445	COG1970	mechanosensitive ion channel activity
I5V48_RS07450	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I5V48_RS07455	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I5V48_RS07460	COG2826	transposase and inactivated derivatives, IS30 family
I5V48_RS07470	COG0647	UMP catabolic process
I5V48_RS07475	COG1051	belongs to the nudix hydrolase family
I5V48_RS07485	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I5V48_RS07495	COG0582	viral genome integration into host DNA
I5V48_RS07505	COG1724	mRNA binding
I5V48_RS07520	COG0813	purine-nucleoside phosphorylase activity
I5V48_RS07525	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I5V48_RS07535	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I5V48_RS07540	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I5V48_RS07545	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I5V48_RS07555	COG1704	LemA family
I5V48_RS07565	COG1573	uracil-dna glycosylase
I5V48_RS07595	COG0488	(ABC) transporter
I5V48_RS07600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I5V48_RS07615	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I5V48_RS07620	COG3442	glutamine amidotransferase
I5V48_RS07625	COG2226	methyltransferase
I5V48_RS07635	COG0488	(ABC) transporter
I5V48_RS07680	COG0201	protein transport
I5V48_RS07685	COG1215	transferase activity, transferring glycosyl groups
I5V48_RS07695	COG1442	glycosyl transferase family 8
I5V48_RS07700	COG1442	glycosyl transferase family 8
I5V48_RS07705	COG1215	transferase activity, transferring glycosyl groups
I5V48_RS07715	COG1216	Glycosyl transferase, family 2
I5V48_RS07715	COG1442	glycosyl transferase family 8
I5V48_RS07730	COG1442	glycosyl transferase family 8
I5V48_RS07730	COG1216	Glycosyl transferase, family 2
I5V48_RS07775	COG1442	glycosyl transferase family 8
I5V48_RS07775	COG1216	Glycosyl transferase, family 2
I5V48_RS07780	COG3842	ATPase activity
I5V48_RS07795	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I5V48_RS07800	COG3527	Alpha-acetolactate decarboxylase
I5V48_RS07810	COG0628	permease
I5V48_RS07815	COG2706	6-phosphogluconolactonase activity
I5V48_RS07910	COG0560	Phosphoserine phosphatase
I5V48_RS07915	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I5V48_RS07920	COG0187	DNA topoisomerase II activity
I5V48_RS07925	COG0693	protein deglycase activity
I5V48_RS07930	COG0772	Belongs to the SEDS family
I5V48_RS07950	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I5V48_RS07955	COG0716	FMN binding
I5V48_RS07965	COG0287	Prephenate dehydrogenase
I5V48_RS07965	COG1605	Chorismate mutase
I5V48_RS07970	COG0038	chloride channel
I5V48_RS07980	COG0737	Belongs to the 5'-nucleotidase family
I5V48_RS07985	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I5V48_RS07990	COG1466	dna polymerase III delta subunit
I5V48_RS07995	COG3064	Membrane
I5V48_RS08010	COG0658	competence protein
I5V48_RS08010	COG2333	competence protein COMEC
I5V48_RS08015	COG1596	polysaccharide export
I5V48_RS08015	COG1555	photosystem II stabilization
I5V48_RS08020	COG0204	Acyl-transferase
I5V48_RS08025	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I5V48_RS08030	COG1120	ATPase activity
I5V48_RS08035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5V48_RS08040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5V48_RS08045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5V48_RS08055	COG0386	Belongs to the glutathione peroxidase family
I5V48_RS08060	COG1187	pseudouridine synthase activity
I5V48_RS08065	COG0435	Glutathione S-transferase
I5V48_RS08075	COG0363	glucosamine-6-phosphate deaminase activity
I5V48_RS08080	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I5V48_RS08085	COG1438	arginine binding
I5V48_RS08095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I5V48_RS08100	COG1288	antiporter activity
I5V48_RS08105	COG0549	Belongs to the carbamate kinase family
I5V48_RS08110	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I5V48_RS08115	COG0454	-acetyltransferase
I5V48_RS08135	COG1481	regulation of sporulation
I5V48_RS08140	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I5V48_RS08145	COG1660	Displays ATPase and GTPase activities
I5V48_RS08150	COG0251	oxidation-reduction process
I5V48_RS08170	COG0436	Aminotransferase
I5V48_RS08185	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I5V48_RS08190	COG0562	UDP-galactopyranose mutase
I5V48_RS08215	COG0438	transferase activity, transferring glycosyl groups
I5V48_RS08220	COG1215	transferase activity, transferring glycosyl groups
I5V48_RS08230	COG0438	transferase activity, transferring glycosyl groups
I5V48_RS08235	COG0110	maltose O-acetyltransferase activity
I5V48_RS08240	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I5V48_RS08245	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I5V48_RS08250	COG3177	Filamentation induced by cAMP protein fic
I5V48_RS08260	COG4464	protein tyrosine phosphatase activity
I5V48_RS08270	COG3944	biosynthesis protein
I5V48_RS08275	COG1316	TRANSCRIPTIONal
I5V48_RS08280	COG3022	response to hydroperoxide
I5V48_RS08285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5V48_RS08300	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I5V48_RS08305	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I5V48_RS08310	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I5V48_RS08315	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I5V48_RS08315	COG1199	ATP-dependent helicase activity
I5V48_RS08325	COG3590	peptidase
I5V48_RS08330	COG1702	phosphate starvation-inducible protein PhoH
I5V48_RS08335	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I5V48_RS08335	COG3583	domain protein
I5V48_RS08340	COG3583	domain protein
I5V48_RS08345	COG4479	Belongs to the UPF0346 family
I5V48_RS08360	COG2996	Protein conserved in bacteria
I5V48_RS08365	COG0233	cytoplasmic translational termination
I5V48_RS08370	COG0528	UMP kinase activity
I5V48_RS08375	COG2244	polysaccharide biosynthetic process
I5V48_RS08380	COG0625	glutathione transferase activity
I5V48_RS08420	COG0346	lactoylglutathione lyase activity
I5V48_RS08425	COG0697	spore germination
I5V48_RS08425	COG1674	ftsk spoiiie
I5V48_RS08430	COG1621	beta-fructofuranosidase activity
I5V48_RS08440	COG0395	ABC-type sugar transport system, permease component
I5V48_RS08445	COG4209	transmembrane transport
I5V48_RS08450	COG1609	Transcriptional regulator
I5V48_RS08470	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I5V48_RS08495	COG0494	nUDIX hydrolase
I5V48_RS08500	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I5V48_RS08520	COG1028	Short-chain dehydrogenase reductase Sdr
I5V48_RS08550	COG0577	efflux transmembrane transporter activity
I5V48_RS08555	COG1136	(ABC) transporter
I5V48_RS08560	COG2205	protein histidine kinase activity
I5V48_RS08565	COG0745	RESPONSE REGULATOR receiver
I5V48_RS08585	COG1174	glycine betaine transport
I5V48_RS08590	COG1125	glycine betaine transport
I5V48_RS08590	COG0517	IMP dehydrogenase activity
I5V48_RS08610	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I5V48_RS08615	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I5V48_RS08620	COG1482	cell wall glycoprotein biosynthetic process
I5V48_RS08625	COG2723	6-phospho-beta-galactosidase activity
I5V48_RS08630	COG1940	carbohydrate kinase activity
I5V48_RS08640	COG2273	Hydrolase Family 16
I5V48_RS08645	COG2273	Hydrolase Family 16
I5V48_RS08650	COG0395	ABC-type sugar transport system, permease component
I5V48_RS08685	COG3091	SprT-like family
I5V48_RS08690	COG2183	response to ionizing radiation
I5V48_RS08695	COG0656	L-ascorbic acid biosynthetic process
I5V48_RS08700	COG4708	membrane
I5V48_RS08705	COG2246	polysaccharide biosynthetic process
I5V48_RS08715	COG0024	Methionine aminopeptidase
I5V48_RS08725	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I5V48_RS08730	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I5V48_RS08735	COG2131	deaminase
I5V48_RS08745	COG1363	Peptidase, m42
I5V48_RS08760	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I5V48_RS08765	COG1956	GAF domain-containing protein
I5V48_RS08775	COG1695	Transcriptional regulator
I5V48_RS08785	COG0673	inositol 2-dehydrogenase activity
I5V48_RS08790	COG0513	Belongs to the DEAD box helicase family
I5V48_RS08795	COG0726	polysaccharide deacetylase
I5V48_RS08830	COG0183	Belongs to the thiolase family
I5V48_RS08835	COG3425	synthase
I5V48_RS08850	COG0776	regulation of translation
I5V48_RS08860	COG2755	lipolytic protein G-D-S-L family
I5V48_RS08865	COG1307	EDD domain protein, DegV family
I5V48_RS08870	COG0497	DNA recombination
I5V48_RS08875	COG1438	arginine binding
I5V48_RS08880	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I5V48_RS08890	COG1722	exodeoxyribonuclease VII activity
I5V48_RS08895	COG1570	exodeoxyribonuclease VII activity
I5V48_RS08905	COG1755	Isoprenylcysteine carboxyl methyltransferase
I5V48_RS08910	COG5002	protein histidine kinase activity
I5V48_RS08915	COG0745	RESPONSE REGULATOR receiver
I5V48_RS08940	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I5V48_RS08950	COG0765	amino acid transport
I5V48_RS08955	COG4703	Protein of unknown function (DUF1797)
I5V48_RS08960	COG0542	response to heat
I5V48_RS08970	COG0494	nUDIX hydrolase
I5V48_RS08970	COG0406	alpha-ribazole phosphatase activity
I5V48_RS08990	COG3599	regulation of cell shape
I5V48_RS09005	COG1799	cell septum assembly
I5V48_RS09010	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I5V48_RS09015	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I5V48_RS09030	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I5V48_RS09045	COG1217	gtp-binding protein TYPA
I5V48_RS09095	COG0346	lactoylglutathione lyase activity
I5V48_RS09125	COG3716	PTS system mannose fructose sorbose family IID component
I5V48_RS09130	COG3715	PTS system
I5V48_RS09135	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5V48_RS09145	COG2188	Transcriptional regulator
I5V48_RS09150	COG2188	Transcriptional regulator
I5V48_RS09160	COG3557	Belongs to the UPF0374 family
I5V48_RS09170	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I5V48_RS09255	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I5V48_RS09260	COG1739	Uncharacterized protein family UPF0029
I5V48_RS09270	COG1098	S1 RNA binding domain
I5V48_RS09300	COG2815	serine threonine protein kinase
I5V48_RS09300	COG0515	serine threonine protein kinase
I5V48_RS09305	COG0631	protein serine/threonine phosphatase activity
I5V48_RS09310	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I5V48_RS09310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I5V48_RS09315	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I5V48_RS09320	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I5V48_RS09325	COG1758	RNA polymerase activity
I5V48_RS09335	COG1418	mRNA catabolic process
I5V48_RS09340	COG1854	S-ribosylhomocysteine lyase activity
I5V48_RS09350	COG0116	Belongs to the methyltransferase superfamily
I5V48_RS09360	COG3599	regulation of cell shape
I5V48_RS09365	COG4474	Belongs to the UPF0398 family
I5V48_RS09370	COG3331	DNA recombination
I5V48_RS09375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5V48_RS09380	COG0357	Ribosomal RNA small subunit methyltransferase G
I5V48_RS09400	COG1122	ATPase activity
I5V48_RS09410	COG1054	Belongs to the UPF0176 family
I5V48_RS09425	COG4720	Psort location CytoplasmicMembrane, score
I5V48_RS09435	COG0217	transcriptional regulatory protein
I5V48_RS09450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5V48_RS09450	COG2190	(PTS) system
I5V48_RS09450	COG1263	PTS System
I5V48_RS09465	COG0058	SHG alpha-glucan phosphorylase activity
I5V48_RS09470	COG1640	4-alpha-glucanotransferase
I5V48_RS09480	COG0242	peptide deformylase activity
I5V48_RS09515	COG2226	methyltransferase
I5V48_RS09520	COG0799	negative regulation of ribosome biogenesis
I5V48_RS09525	COG1335	isochorismatase
I5V48_RS09540	COG1713	HD superfamily hydrolase involved in NAD metabolism
I5V48_RS09545	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I5V48_RS09550	COG1534	Rna-binding protein
I5V48_RS09555	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I5V48_RS09570	COG3142	Participates in the control of copper homeostasis
I5V48_RS09575	COG0697	spore germination
I5V48_RS09580	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I5V48_RS09585	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I5V48_RS09590	COG1609	Transcriptional regulator
I5V48_RS09600	COG0464	growth
I5V48_RS09635	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I5V48_RS09640	COG0154	amidase activity
I5V48_RS09645	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I5V48_RS09655	COG0335	large ribosomal subunit rRNA binding
I5V48_RS09690	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I5V48_RS09695	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I5V48_RS09705	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I5V48_RS09710	COG0195	Participates in both transcription termination and antitermination
I5V48_RS09720	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I5V48_RS09730	COG4473	ABC transporter
I5V48_RS09735	COG1131	(ABC) transporter
I5V48_RS09740	COG0537	adenosine 5'-monophosphoramidase activity
I5V48_RS09750	COG1316	TRANSCRIPTIONal
I5V48_RS09760	COG0802	atpase or kinase
I5V48_RS09765	COG1461	Dihydroxyacetone kinase
I5V48_RS09775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5V48_RS09780	COG0601	transmembrane transport
I5V48_RS09785	COG4608	Belongs to the ABC transporter superfamily
I5V48_RS09800	COG1686	Belongs to the peptidase S11 family
I5V48_RS09815	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I5V48_RS09820	COG0719	Fe-S assembly protein
I5V48_RS09830	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I5V48_RS09835	COG4862	establishment of competence for transformation
I5V48_RS09840	COG1968	undecaprenyl-diphosphatase activity
I5V48_RS09845	COG0765	amino acid transport
I5V48_RS09865	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I5V48_RS09870	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I5V48_RS09875	COG0440	acetolactate synthase activity
I5V48_RS09880	COG0028	Belongs to the TPP enzyme family
I5V48_RS09900	COG0129	dihydroxy-acid dehydratase activity
I5V48_RS09905	COG1442	glycosyl transferase family 8
I5V48_RS09915	COG2151	metal-sulfur cluster biosynthetic enzyme
I5V48_RS10025	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I5V48_RS10045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5V48_RS10065	COG3842	ATPase activity
I5V48_RS10075	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I5V48_RS10095	COG1045	serine acetyltransferase
I5V48_RS10100	COG1185	polyribonucleotide nucleotidyltransferase activity
I5V48_RS10105	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I5V48_RS10135	COG0464	growth
I5V48_RS10150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I5V48_RS10155	COG1187	pseudouridine synthase activity
I5V48_RS10175	COG0242	peptide deformylase activity
I5V48_RS10205	COG0066	3-isopropylmalate dehydratase activity
I5V48_RS10230	COG2309	aminopeptidase activity
I5V48_RS10240	COG2176	DNA-directed DNA polymerase activity
I5V48_RS10245	COG2376	Dihydroxyacetone kinase
I5V48_RS10255	COG2376	Dihydroxyacetone kinase
I5V48_RS10260	COG1461	Dihydroxyacetone kinase
I5V48_RS10265	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I5V48_RS10270	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I5V48_RS10275	COG0442	prolyl-tRNA aminoacylation
I5V48_RS10285	COG4589	Belongs to the CDS family
I5V48_RS10290	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I5V48_RS10315	COG3583	domain protein
I5V48_RS10355	COG1862	Preprotein translocase
I5V48_RS10365	COG1181	Belongs to the D-alanine--D-alanine ligase family
I5V48_RS10365	COG2918	glutathione biosynthetic process
I5V48_RS10380	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I5V48_RS10385	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I5V48_RS10400	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I5V48_RS10405	COG0542	response to heat
I5V48_RS10410	COG4463	regulation of RNA biosynthetic process
I5V48_RS10425	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I5V48_RS10560	COG0582	viral genome integration into host DNA
I5V48_RS10725	COG0582	viral genome integration into host DNA
I5V48_RS10745	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I5V48_RS10750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5V48_RS10755	COG0492	ferredoxin-NADP+ reductase activity
I5V48_RS10760	COG0564	pseudouridine synthase activity
I5V48_RS10815	COG0823	Involved in the tonB-independent uptake of proteins
I5V48_RS10825	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I5V48_RS10845	COG1564	THIamine pyrophosphokinase
I5V48_RS10855	COG1162	GTPase activity
I5V48_RS10875	COG1132	(ABC) transporter
I5V48_RS10935	COG0084	hydrolase, TatD family'
I5V48_RS10945	COG1847	R3H domain protein
I5V48_RS10955	COG0594	ribonuclease P activity
I5V48_RS10960	COG0165	Argininosuccinate lyase
I5V48_RS10965	COG0137	argininosuccinate synthase activity
I5V48_RS10985	COG2040	homocysteine
I5V48_RS10990	COG0833	amino acid
I5V48_RS11025	COG3764	Sortase (surface protein transpeptidase)
I5V48_RS11050	COG0756	dUTP diphosphatase activity
I5V48_RS11065	COG1132	(ABC) transporter
I5V48_RS11070	COG1132	(ABC) transporter
I5V48_RS11080	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I5V48_RS11085	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I5V48_RS11090	COG0705	Rhomboid family
I5V48_RS11095	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I5V48_RS11100	COG1473	amidohydrolase
I5V48_RS11105	COG2171	N-acyltransferase activity
I5V48_RS11115	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I5V48_RS11140	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I5V48_RS11165	COG3623	hexulose-6-phosphate isomerase
I5V48_RS11190	COG1523	belongs to the glycosyl hydrolase 13 family
I5V48_RS11195	COG1609	Transcriptional regulator
I5V48_RS11205	COG3942	CHAP domain
I5V48_RS11210	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5V48_RS11220	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5V48_RS11230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5V48_RS11230	COG3711	transcriptional antiterminator
I5V48_RS11240	COG2723	6-phospho-beta-galactosidase activity
I5V48_RS11245	COG1486	melibiose metabolic process
I5V48_RS11255	COG3590	peptidase
I5V48_RS11260	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5V48_RS11265	COG1321	iron dependent repressor
I5V48_RS11265	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5V48_RS11270	COG1121	(ABC) transporter
I5V48_RS11280	COG0803	Belongs to the bacterial solute-binding protein 9 family
I5V48_RS11300	COG1490	D-aminoacyl-tRNA deacylase activity
I5V48_RS11310	COG0737	Belongs to the 5'-nucleotidase family
I5V48_RS11325	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I5V48_RS11350	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I5V48_RS11385	COG1328	CTP reductase activity
I5V48_RS11420	COG1438	arginine binding
I5V48_RS11425	COG0018	arginyl-trna synthetase
I5V48_RS11445	COG1640	4-alpha-glucanotransferase
I5V48_RS11450	COG2182	Extracellular solute-binding protein
I5V48_RS11455	COG1175	transmembrane transport
I5V48_RS11460	COG3833	ABC-type maltose transport systems, permease component
I5V48_RS11465	COG5521	maltodextrose utilization protein MalA
I5V48_RS11470	COG1609	Transcriptional regulator
I5V48_RS11475	COG1523	belongs to the glycosyl hydrolase 13 family
I5V48_RS11480	COG1780	Probably involved in ribonucleotide reductase function
I5V48_RS11485	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I5V48_RS11490	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I5V48_RS11495	COG2153	protein acetylation
I5V48_RS11500	COG4989	oxidoreductase activity
I5V48_RS11505	COG1216	Glycosyl transferase, family 2
I5V48_RS11640	COG0582	viral genome integration into host DNA
I5V48_RS11645	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I5V48_RS11650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5V48_RS11655	COG0785	Cytochrome C biogenesis protein
I5V48_RS11665	COG0305	Participates in initiation and elongation during chromosome replication
I5V48_RS11670	COG0359	binds to the 23S rRNA
I5V48_RS11680	COG0445	tRNA wobble uridine modification
I5V48_RS11685	COG0494	nUDIX hydrolase
I5V48_RS11700	COG1733	regulation of RNA biosynthetic process
I5V48_RS11710	COG0482	sulfurtransferase activity
I5V48_RS11715	COG1760	l-serine dehydratase
I5V48_RS11720	COG1760	l-serine dehydratase
I5V48_RS11730	COG0745	RESPONSE REGULATOR receiver
I5V48_RS11735	COG5002	protein histidine kinase activity
I5V48_RS11745	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I5V48_RS11750	COG1122	ATPase activity
I5V48_RS11755	COG1122	ATPase activity
I5V48_RS11760	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I5V48_RS11765	COG1426	Protein conserved in bacteria
I5V48_RS11770	COG0612	Peptidase, M16
I5V48_RS11775	COG0612	Peptidase, M16
I5V48_RS11855	COG0582	viral genome integration into host DNA
I5V48_RS11865	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I5V48_RS11870	COG0517	IMP dehydrogenase activity
I5V48_RS11870	COG0516	GMP reductase activity
I5V48_RS11880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I5V48_RS11885	COG0488	(ABC) transporter
I5V48_RS11930	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I5V48_RS11935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5V48_RS11940	COG1475	DNA binding