locus-tag	class	description
ZY05719_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ZY05719_RS00010	COG0592	DNA-directed DNA polymerase activity
ZY05719_RS00030	COG0012	GTP binding
ZY05719_RS00035	COG0193	aminoacyl-tRNA hydrolase activity
ZY05719_RS00040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ZY05719_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ZY05719_RS00065	COG0037	tRNA processing
ZY05719_RS00075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ZY05719_RS00185	COG1792	Involved in formation and maintenance of cell shape
ZY05719_RS00200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ZY05719_RS00205	COG0436	Aminotransferase
ZY05719_RS00210	COG1381	Involved in DNA repair and RecF pathway recombination
ZY05719_RS00215	COG0416	fatty acid biosynthetic process
ZY05719_RS00220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ZY05719_RS00230	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ZY05719_RS00245	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ZY05719_RS00250	COG0138	bifunctional purine biosynthesis protein purh
ZY05719_RS00255	COG0151	Belongs to the GarS family
ZY05719_RS00260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ZY05719_RS00280	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ZY05719_RS00300	COG1131	(ABC) transporter
ZY05719_RS00310	COG1132	(ABC) transporter
ZY05719_RS00315	COG2255	four-way junction helicase activity
ZY05719_RS00325	COG0546	phosphoglycolate phosphatase activity
ZY05719_RS00350	COG0285	dihydrofolate synthase activity
ZY05719_RS00365	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ZY05719_RS00370	COG0632	four-way junction helicase activity
ZY05719_RS00380	COG0519	Catalyzes the synthesis of GMP from XMP
ZY05719_RS00395	COG1393	Belongs to the ArsC family
ZY05719_RS00400	COG4472	Bacterial protein of unknown function (DUF965)
ZY05719_RS00405	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ZY05719_RS00410	COG3906	Belongs to the UPF0473 family
ZY05719_RS00430	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ZY05719_RS00435	COG0088	Forms part of the polypeptide exit tunnel
ZY05719_RS00440	COG0089	rRNA binding
ZY05719_RS00445	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ZY05719_RS00450	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ZY05719_RS00455	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ZY05719_RS00460	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ZY05719_RS00465	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ZY05719_RS00470	COG0255	Belongs to the universal ribosomal protein uL29 family
ZY05719_RS00475	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ZY05719_RS00480	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ZY05719_RS00485	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ZY05719_RS00490	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ZY05719_RS00495	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ZY05719_RS00505	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ZY05719_RS00515	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ZY05719_RS00520	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ZY05719_RS00525	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ZY05719_RS00530	COG1841	ribosomal large subunit assembly
ZY05719_RS00540	COG0201	protein transport
ZY05719_RS00545	COG0563	adenylate kinase activity
ZY05719_RS00550	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ZY05719_RS00555	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ZY05719_RS00560	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ZY05719_RS00570	COG0202	RNA polymerase activity
ZY05719_RS00660	COG0582	viral genome integration into host DNA
ZY05719_RS00670	COG2946	Replication initiation factor
ZY05719_RS00715	COG1121	(ABC) transporter
ZY05719_RS00720	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ZY05719_RS00725	COG0803	Belongs to the bacterial solute-binding protein 9 family
ZY05719_RS00725	COG3443	Belongs to the bacterial solute-binding protein 9 family
ZY05719_RS00755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ZY05719_RS00760	COG0085	RNA polymerase activity
ZY05719_RS00765	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ZY05719_RS00780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ZY05719_RS00785	COG1459	type II secretion system
ZY05719_RS00790	COG4537	Required for transformation and DNA binding
ZY05719_RS00820	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ZY05719_RS00830	COG0285	dihydrofolate synthase activity
ZY05719_RS00835	COG1363	Peptidase, m42
ZY05719_RS00845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ZY05719_RS00855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ZY05719_RS00880	COG0459	protein refolding
ZY05719_RS00890	COG0049	tRNA binding
ZY05719_RS00895	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ZY05719_RS00900	COG3590	peptidase
ZY05719_RS00910	COG0126	phosphoglycerate kinase activity
ZY05719_RS00920	COG0789	Transcriptional regulator
ZY05719_RS00925	COG0174	glutamine synthetase
ZY05719_RS00940	COG1214	PFAM Peptidase M22, glycoprotease
ZY05719_RS00950	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ZY05719_RS00955	COG2207	Transcriptional regulator
ZY05719_RS00965	COG1175	transmembrane transport
ZY05719_RS00970	COG0395	ABC-type sugar transport system, permease component
ZY05719_RS00990	COG2855	membrane
ZY05719_RS01015	COG1131	(ABC) transporter
ZY05719_RS01020	COG2081	HI0933 family
ZY05719_RS01025	COG2723	6-phospho-beta-galactosidase activity
ZY05719_RS01035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ZY05719_RS01050	COG3959	Transketolase, thiamine diphosphate binding domain
ZY05719_RS01055	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ZY05719_RS01060	COG0584	glycerophosphoryl diester phosphodiesterase
ZY05719_RS01065	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ZY05719_RS01070	COG2222	sugar isomerase
ZY05719_RS01090	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ZY05719_RS01095	COG1882	Formate acetyltransferase
ZY05719_RS01110	COG2910	NAD(P)H-binding
ZY05719_RS01135	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ZY05719_RS01170	COG0363	glucosamine-6-phosphate deaminase activity
ZY05719_RS01180	COG2217	Heavy metal translocating P-type atpase
ZY05719_RS01185	COG2217	Heavy metal translocating P-type atpase
ZY05719_RS01190	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ZY05719_RS01195	COG0681	Belongs to the peptidase S26 family
ZY05719_RS01215	COG0366	Alpha amylase catalytic
ZY05719_RS01220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ZY05719_RS01220	COG1263	PTS System
ZY05719_RS01225	COG2188	Transcriptional regulator
ZY05719_RS01240	COG1193	negative regulation of DNA recombination
ZY05719_RS01250	COG3118	belongs to the thioredoxin family
ZY05719_RS01255	COG0318	PFAM AMP-dependent synthetase and ligase
ZY05719_RS01260	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ZY05719_RS01260	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ZY05719_RS01285	COG1115	amino acid carrier protein
ZY05719_RS01290	COG0668	transmembrane transport
ZY05719_RS01305	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ZY05719_RS01310	COG0167	dihydroorotate dehydrogenase activity
ZY05719_RS01315	COG2843	Capsule synthesis protein
ZY05719_RS01320	COG0561	phosphatase activity
ZY05719_RS01335	COG1131	(ABC) transporter
ZY05719_RS01340	COG1309	transcriptional regulator
ZY05719_RS01345	COG1511	domain protein
ZY05719_RS01370	COG1346	cytolysis
ZY05719_RS01375	COG2116	formate transmembrane transporter activity
ZY05719_RS01380	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ZY05719_RS01385	COG0433	COG0433 Predicted ATPase
ZY05719_RS01390	COG0494	nUDIX hydrolase
ZY05719_RS01415	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ZY05719_RS01420	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ZY05719_RS01425	COG0124	histidyl-tRNA synthetase
ZY05719_RS01430	COG1064	alcohol dehydrogenase
ZY05719_RS01435	COG1012	belongs to the aldehyde dehydrogenase family
ZY05719_RS01435	COG1454	alcohol dehydrogenase
ZY05719_RS01445	COG4988	ABC transporter
ZY05719_RS01450	COG1132	(ABC) transporter
ZY05719_RS01465	COG1129	ABC transporter
ZY05719_RS01470	COG0534	Mate efflux family protein
ZY05719_RS01475	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ZY05719_RS01490	COG1304	FMN binding
ZY05719_RS01495	COG1132	(ABC) transporter
ZY05719_RS01500	COG1132	(ABC) transporter
ZY05719_RS01505	COG3830	Belongs to the UPF0237 family
ZY05719_RS01510	COG2848	UPF0210 protein
ZY05719_RS01515	COG0588	phosphoglycerate mutase activity
ZY05719_RS01520	COG1420	regulation of RNA biosynthetic process
ZY05719_RS01525	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ZY05719_RS01530	COG0443	Heat shock 70 kDa protein
ZY05719_RS01535	COG0484	heat shock protein binding
ZY05719_RS01540	COG0095	Lipoate-protein ligase
ZY05719_RS01550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ZY05719_RS01555	COG0765	amino acid transport
ZY05719_RS01560	COG3655	Transcriptional regulator
ZY05719_RS01570	COG2217	Heavy metal translocating P-type atpase
ZY05719_RS01595	COG4475	Protein of unknown function (DUF436)
ZY05719_RS01625	COG4221	oxidoreductase activity
ZY05719_RS01630	COG1902	pentaerythritol trinitrate reductase activity
ZY05719_RS01630	COG0446	pyridine nucleotide-disulphide oxidoreductase
ZY05719_RS01635	COG1959	2 iron, 2 sulfur cluster binding
ZY05719_RS01655	COG0544	peptidyl-prolyl cis-trans isomerase activity
ZY05719_RS01675	COG3343	RNA polymerase activity
ZY05719_RS01680	COG0504	CTP synthase activity
ZY05719_RS01690	COG0191	fructose-bisphosphate aldolase activity
ZY05719_RS01695	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ZY05719_RS01730	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ZY05719_RS01735	COG0252	asparaginase activity
ZY05719_RS01750	COG0589	response to stress
ZY05719_RS01755	COG0436	Aminotransferase
ZY05719_RS01760	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ZY05719_RS01765	COG1335	isochorismatase
ZY05719_RS01770	COG0335	large ribosomal subunit rRNA binding
ZY05719_RS01780	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ZY05719_RS01785	COG0154	amidase activity
ZY05719_RS01790	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ZY05719_RS01795	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ZY05719_RS01800	COG1609	Transcriptional regulator
ZY05719_RS01805	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ZY05719_RS01810	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
ZY05719_RS01820	COG3142	Participates in the control of copper homeostasis
ZY05719_RS01835	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ZY05719_RS01840	COG1534	Rna-binding protein
ZY05719_RS01845	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ZY05719_RS01850	COG1713	HD superfamily hydrolase involved in NAD metabolism
ZY05719_RS01860	COG1335	isochorismatase
ZY05719_RS01865	COG0799	negative regulation of ribosome biogenesis
ZY05719_RS01870	COG2226	methyltransferase
ZY05719_RS01875	COG5290	Psort location Cytoplasmic, score
ZY05719_RS01885	COG0789	Transcriptional regulator
ZY05719_RS01890	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ZY05719_RS01910	COG0242	peptide deformylase activity
ZY05719_RS01920	COG1640	4-alpha-glucanotransferase
ZY05719_RS01925	COG0058	SHG alpha-glucan phosphorylase activity
ZY05719_RS01940	COG1263	PTS System
ZY05719_RS01940	COG2190	(PTS) system
ZY05719_RS01940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ZY05719_RS01955	COG0217	transcriptional regulatory protein
ZY05719_RS01965	COG4720	Psort location CytoplasmicMembrane, score
ZY05719_RS01975	COG1054	Belongs to the UPF0176 family
ZY05719_RS01985	COG1122	ATPase activity
ZY05719_RS02000	COG0357	Ribosomal RNA small subunit methyltransferase G
ZY05719_RS02005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ZY05719_RS02010	COG3331	DNA recombination
ZY05719_RS02015	COG4474	Belongs to the UPF0398 family
ZY05719_RS02020	COG3599	regulation of cell shape
ZY05719_RS02030	COG0116	Belongs to the methyltransferase superfamily
ZY05719_RS02040	COG1854	S-ribosylhomocysteine lyase activity
ZY05719_RS02045	COG1418	mRNA catabolic process
ZY05719_RS02055	COG1758	RNA polymerase activity
ZY05719_RS02060	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ZY05719_RS02065	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ZY05719_RS02070	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ZY05719_RS02070	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ZY05719_RS02075	COG0631	protein serine/threonine phosphatase activity
ZY05719_RS02080	COG0515	serine threonine protein kinase
ZY05719_RS02080	COG2815	serine threonine protein kinase
ZY05719_RS02105	COG1098	S1 RNA binding domain
ZY05719_RS02115	COG1739	Uncharacterized protein family UPF0029
ZY05719_RS02120	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
ZY05719_RS02200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ZY05719_RS02205	COG2137	regulation of response to DNA damage stimulus
ZY05719_RS02210	COG3557	Belongs to the UPF0374 family
ZY05719_RS02220	COG2188	Transcriptional regulator
ZY05719_RS02225	COG2188	Transcriptional regulator
ZY05719_RS02235	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ZY05719_RS02245	COG3716	PTS system mannose fructose sorbose family IID component
ZY05719_RS02255	COG2017	converts alpha-aldose to the beta-anomer
ZY05719_RS02270	COG0346	lactoylglutathione lyase activity
ZY05719_RS02320	COG1217	gtp-binding protein TYPA
ZY05719_RS02335	COG0681	Belongs to the peptidase S26 family
ZY05719_RS02365	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ZY05719_RS02380	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ZY05719_RS02385	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ZY05719_RS02390	COG1799	cell septum assembly
ZY05719_RS02405	COG3599	regulation of cell shape
ZY05719_RS02425	COG0494	nUDIX hydrolase
ZY05719_RS02425	COG0406	alpha-ribazole phosphatase activity
ZY05719_RS02430	COG0542	response to heat
ZY05719_RS02435	COG4703	Protein of unknown function (DUF1797)
ZY05719_RS02440	COG0765	amino acid transport
ZY05719_RS02450	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ZY05719_RS02480	COG0789	Transcriptional regulator
ZY05719_RS02495	COG0826	peptidase U32
ZY05719_RS02510	COG4443	Transcriptional Coactivator p15 (PC4)
ZY05719_RS02515	COG1268	BioY protein
ZY05719_RS02520	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ZY05719_RS02525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ZY05719_RS02530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZY05719_RS02535	COG1136	(ABC) transporter
ZY05719_RS02540	COG0577	efflux transmembrane transporter activity
ZY05719_RS02555	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ZY05719_RS02565	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ZY05719_RS02575	COG3859	Proton-coupled thiamine transporter YuaJ
ZY05719_RS02595	COG0772	Belongs to the SEDS family
ZY05719_RS02600	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ZY05719_RS02605	COG1595	DNA-templated transcription, initiation
ZY05719_RS02615	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ZY05719_RS02620	COG0149	triose-phosphate isomerase activity
ZY05719_RS02630	COG1078	dGTPase activity
ZY05719_RS02645	COG2826	transposase and inactivated derivatives, IS30 family
ZY05719_RS02650	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ZY05719_RS02660	COG1131	(ABC) transporter
ZY05719_RS02665	COG2188	Transcriptional regulator
ZY05719_RS02675	COG0205	6-phosphofructokinase activity
ZY05719_RS02680	COG0469	pyruvate kinase activity
ZY05719_RS02690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ZY05719_RS02695	COG0657	acetylesterase activity
ZY05719_RS02695	COG2755	lipolytic protein G-D-S-L family
ZY05719_RS02705	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ZY05719_RS02710	COG0765	amino acid transport
ZY05719_RS02715	COG1126	abc transporter atp-binding protein
ZY05719_RS02720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ZY05719_RS02735	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ZY05719_RS02740	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ZY05719_RS02745	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ZY05719_RS02760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ZY05719_RS02765	COG3022	response to hydroperoxide
ZY05719_RS02775	COG3944	biosynthesis protein
ZY05719_RS02785	COG4464	protein tyrosine phosphatase activity
ZY05719_RS02800	COG0438	transferase activity, transferring glycosyl groups
ZY05719_RS02815	COG1442	glycosyl transferase family 8
ZY05719_RS02815	COG1216	Glycosyl transferase, family 2
ZY05719_RS02820	COG1442	glycosyl transferase family 8
ZY05719_RS02820	COG1216	Glycosyl transferase, family 2
ZY05719_RS02850	COG2089	acid synthase
ZY05719_RS02865	COG1083	cytidylyl-transferase
ZY05719_RS02865	COG2755	lipolytic protein G-D-S-L family
ZY05719_RS02950	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ZY05719_RS02955	COG0077	Prephenate dehydratase
ZY05719_RS02965	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ZY05719_RS02970	COG0562	UDP-galactopyranose mutase
ZY05719_RS02975	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ZY05719_RS03000	COG0436	Aminotransferase
ZY05719_RS03020	COG0534	Mate efflux family protein
ZY05719_RS03025	COG0251	oxidation-reduction process
ZY05719_RS03030	COG1660	Displays ATPase and GTPase activities
ZY05719_RS03035	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ZY05719_RS03040	COG1481	regulation of sporulation
ZY05719_RS03055	COG0454	-acetyltransferase
ZY05719_RS03060	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ZY05719_RS03065	COG0549	Belongs to the carbamate kinase family
ZY05719_RS03070	COG1288	antiporter activity
ZY05719_RS03075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ZY05719_RS03080	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ZY05719_RS03080	COG3583	domain protein
ZY05719_RS03080	COG3064	Membrane
ZY05719_RS03085	COG1438	arginine binding
ZY05719_RS03090	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ZY05719_RS03095	COG0363	glucosamine-6-phosphate deaminase activity
ZY05719_RS03125	COG1696	Membrane protein involved in D-alanine export
ZY05719_RS03130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ZY05719_RS03135	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
ZY05719_RS03145	COG0435	Glutathione S-transferase
ZY05719_RS03150	COG1187	pseudouridine synthase activity
ZY05719_RS03155	COG0386	Belongs to the glutathione peroxidase family
ZY05719_RS03160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ZY05719_RS03165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ZY05719_RS03170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ZY05719_RS03175	COG1120	ATPase activity
ZY05719_RS03180	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ZY05719_RS03185	COG0204	Acyl-transferase
ZY05719_RS03190	COG1555	photosystem II stabilization
ZY05719_RS03190	COG1596	polysaccharide export
ZY05719_RS03195	COG2333	competence protein COMEC
ZY05719_RS03195	COG0658	competence protein
ZY05719_RS03205	COG0517	IMP dehydrogenase activity
ZY05719_RS03220	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ZY05719_RS03225	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ZY05719_RS03230	COG0470	DNA polymerase III
ZY05719_RS03235	COG4467	Involved in initiation control of chromosome replication
ZY05719_RS03245	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ZY05719_RS03255	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ZY05719_RS03260	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ZY05719_RS03265	COG1393	Belongs to the ArsC family
ZY05719_RS03275	COG0708	Exodeoxyribonuclease III
ZY05719_RS03285	COG0531	amino acid
ZY05719_RS03335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ZY05719_RS03340	COG4684	Psort location CytoplasmicMembrane, score
ZY05719_RS03345	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ZY05719_RS03355	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ZY05719_RS03365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ZY05719_RS03370	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ZY05719_RS03385	COG0732	type I restriction modification DNA specificity domain
ZY05719_RS03420	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ZY05719_RS03425	COG1349	DNA-binding transcription factor activity
ZY05719_RS03435	COG1447	Phosphotransferase system cellobiose-specific component IIA
ZY05719_RS03440	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ZY05719_RS03445	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ZY05719_RS03450	COG1882	Formate acetyltransferase
ZY05719_RS03470	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ZY05719_RS03475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ZY05719_RS03480	COG0446	pyridine nucleotide-disulphide oxidoreductase
ZY05719_RS03490	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ZY05719_RS03495	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ZY05719_RS03500	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ZY05719_RS03505	COG0346	lactoylglutathione lyase activity
ZY05719_RS03515	COG1164	Oligoendopeptidase f
ZY05719_RS03530	COG0210	DNA helicase
ZY05719_RS03545	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ZY05719_RS03560	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
ZY05719_RS03575	COG1122	ATPase activity
ZY05719_RS03580	COG1122	ATPase activity
ZY05719_RS03585	COG1011	Hydrolase
ZY05719_RS03615	COG1131	(ABC) transporter
ZY05719_RS03645	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ZY05719_RS03650	COG1074	ATP-dependent DNA helicase activity
ZY05719_RS03660	COG0187	DNA topoisomerase II activity
ZY05719_RS03685	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ZY05719_RS03695	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ZY05719_RS03715	COG0539	negative regulation of cytoplasmic translation
ZY05719_RS03740	COG1104	cysteine desulfurase activity
ZY05719_RS03745	COG0301	tRNA thio-modification
ZY05719_RS03750	COG1114	Component of the transport system for branched-chain amino acids
ZY05719_RS03755	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ZY05719_RS03760	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ZY05719_RS03780	COG0564	pseudouridine synthase activity
ZY05719_RS03785	COG2824	Alkylphosphonate utilization operon protein PhnA
ZY05719_RS03795	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ZY05719_RS03800	COG0540	Belongs to the ATCase OTCase family
ZY05719_RS03805	COG0505	Belongs to the CarA family
ZY05719_RS03815	COG2136	Putative SAM-dependent methyltransferase
ZY05719_RS03815	COG2521	methyltransferase
ZY05719_RS03820	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
ZY05719_RS03830	COG0228	four-way junction DNA binding
ZY05719_RS03845	COG1132	(ABC) transporter
ZY05719_RS03850	COG0726	polysaccharide deacetylase
ZY05719_RS03855	COG0460	homoserine dehydrogenase
ZY05719_RS03860	COG0083	homoserine kinase activity
ZY05719_RS03865	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ZY05719_RS03870	COG3842	ATPase activity
ZY05719_RS03875	COG1176	ABC-type spermidine putrescine transport system, permease component I
ZY05719_RS03880	COG1177	transmembrane transport
ZY05719_RS03890	COG0038	chloride channel
ZY05719_RS03910	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ZY05719_RS03915	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ZY05719_RS03930	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ZY05719_RS03935	COG0336	Belongs to the RNA methyltransferase TrmD family
ZY05719_RS03940	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ZY05719_RS03945	COG1349	DNA-binding transcription factor activity
ZY05719_RS03950	COG1105	Belongs to the carbohydrate kinase PfkB family
ZY05719_RS03955	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ZY05719_RS03955	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ZY05719_RS03955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ZY05719_RS03965	COG1307	EDD domain protein, DegV family
ZY05719_RS03970	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ZY05719_RS03975	COG0617	tRNA 3'-terminal CCA addition
ZY05719_RS03980	COG0488	(ABC) transporter
ZY05719_RS03990	COG1940	carbohydrate kinase activity
ZY05719_RS04005	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ZY05719_RS04010	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ZY05719_RS04020	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ZY05719_RS04040	COG0481	GTPase activity
ZY05719_RS04065	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ZY05719_RS04070	COG2890	protein-(glutamine-N5) methyltransferase activity
ZY05719_RS04075	COG0009	L-threonylcarbamoyladenylate synthase
ZY05719_RS04085	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ZY05719_RS04095	COG0741	lytic transglycosylase activity
ZY05719_RS04100	COG4221	oxidoreductase activity
ZY05719_RS04125	COG1401	restriction endodeoxyribonuclease activity
ZY05719_RS04130	COG4268	DNA restriction-modification system
ZY05719_RS04200	COG2188	Transcriptional regulator
ZY05719_RS04205	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
ZY05719_RS04210	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ZY05719_RS04225	COG1660	Displays ATPase and GTPase activities
ZY05719_RS04235	COG4974	Belongs to the 'phage' integrase family
ZY05719_RS04250	COG0745	RESPONSE REGULATOR receiver
ZY05719_RS04270	COG1136	(ABC) transporter
ZY05719_RS04310	COG2382	esterase
ZY05719_RS04320	COG2207	Transcriptional regulator
ZY05719_RS04320	COG3708	Transcriptional regulator
ZY05719_RS04325	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ZY05719_RS04330	COG0647	UMP catabolic process
ZY05719_RS04335	COG4974	Belongs to the 'phage' integrase family
ZY05719_RS04345	COG1396	sequence-specific DNA binding
ZY05719_RS04370	COG1131	(ABC) transporter
ZY05719_RS04375	COG1132	(ABC) transporter
ZY05719_RS04390	COG3843	relaxase mobilization nuclease domain protein
ZY05719_RS04450	COG0791	NLP P60 protein
ZY05719_RS04450	COG0741	lytic transglycosylase activity
ZY05719_RS04480	COG2946	Replication initiation factor
ZY05719_RS04485	COG1674	ftsk spoiiie
ZY05719_RS04510	COG0542	response to heat
ZY05719_RS04515	COG1396	sequence-specific DNA binding
ZY05719_RS04545	COG2197	response regulator
ZY05719_RS04570	COG1132	(ABC) transporter
ZY05719_RS04605	COG2226	methyltransferase
ZY05719_RS04615	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ZY05719_RS04730	COG0270	DNA (cytosine-5-)-methyltransferase activity
ZY05719_RS04745	COG0222	ribosome binding
ZY05719_RS04750	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ZY05719_RS04755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ZY05719_RS04760	COG0758	DNA mediated transformation
ZY05719_RS04765	COG0110	maltose O-acetyltransferase activity
ZY05719_RS04770	COG1937	Protein conserved in bacteria
ZY05719_RS04780	COG0446	pyridine nucleotide-disulphide oxidoreductase
ZY05719_RS04790	COG1272	protein, Hemolysin III
ZY05719_RS04800	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ZY05719_RS04805	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ZY05719_RS04820	COG0737	Belongs to the 5'-nucleotidase family
ZY05719_RS04830	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ZY05719_RS04835	COG0463	Glycosyl transferase, family 2
ZY05719_RS04845	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ZY05719_RS04850	COG0284	orotidine-5'-phosphate decarboxylase activity
ZY05719_RS04855	COG0167	dihydroorotate dehydrogenase activity
ZY05719_RS04880	COG0297	glycogen (starch) synthase activity
ZY05719_RS04890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ZY05719_RS04895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ZY05719_RS04910	COG3583	domain protein
ZY05719_RS04935	COG1126	abc transporter atp-binding protein
ZY05719_RS04945	COG0488	(ABC) transporter
ZY05719_RS04950	COG2873	o-acetylhomoserine
ZY05719_RS04975	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ZY05719_RS04975	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ZY05719_RS04985	COG3711	transcriptional antiterminator
ZY05719_RS04990	COG3684	Belongs to the aldolase LacD family
ZY05719_RS04995	COG1105	Belongs to the carbohydrate kinase PfkB family
ZY05719_RS05000	COG1105	Belongs to the carbohydrate kinase PfkB family
ZY05719_RS05005	COG0698	ribose 5-phosphate isomerase
ZY05719_RS05010	COG0698	ribose 5-phosphate isomerase
ZY05719_RS05020	COG1349	DNA-binding transcription factor activity
ZY05719_RS05050	COG1396	sequence-specific DNA binding
ZY05719_RS05055	COG1194	a g-specific adenine glycosylase
ZY05719_RS05065	COG1132	(ABC) transporter
ZY05719_RS05070	COG1132	(ABC) transporter
ZY05719_RS05075	COG0280	phosphate acetyltransferase
ZY05719_RS05080	COG0564	pseudouridine synthase activity
ZY05719_RS05085	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ZY05719_RS05090	COG2357	RelA SpoT domain protein
ZY05719_RS05095	COG4116	CYTH
ZY05719_RS05105	COG1104	cysteine desulfurase activity
ZY05719_RS05120	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ZY05719_RS05125	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ZY05719_RS05135	COG3764	Sortase (surface protein transpeptidase)
ZY05719_RS05140	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ZY05719_RS05145	COG0039	L-malate dehydrogenase activity
ZY05719_RS05150	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ZY05719_RS05155	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ZY05719_RS05160	COG1079	Belongs to the binding-protein-dependent transport system permease family
ZY05719_RS05165	COG4603	Belongs to the binding-protein-dependent transport system permease family
ZY05719_RS05170	COG3845	ABC transporter
ZY05719_RS05175	COG1744	ABC transporter substrate-binding protein PnrA-like
ZY05719_RS05190	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ZY05719_RS05195	COG2813	Specifically methylates the guanine in position
ZY05719_RS05200	COG1072	(Pantothenic acid kinase))
ZY05719_RS05230	COG5002	protein histidine kinase activity
ZY05719_RS05235	COG0745	RESPONSE REGULATOR receiver
ZY05719_RS05250	COG0704	Plays a role in the regulation of phosphate uptake
ZY05719_RS05255	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ZY05719_RS05260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ZY05719_RS05265	COG0581	inorganic phosphate transmembrane transporter activity
ZY05719_RS05270	COG0573	inorganic phosphate transmembrane transporter activity
ZY05719_RS05280	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ZY05719_RS05280	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
ZY05719_RS05285	COG0483	inositol monophosphate 1-phosphatase activity
ZY05719_RS05290	COG4476	Belongs to the UPF0223 family
ZY05719_RS05295	COG1393	Belongs to the ArsC family
ZY05719_RS05300	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ZY05719_RS05305	COG0196	riboflavin kinase activity
ZY05719_RS05310	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ZY05719_RS05370	COG0561	phosphatase activity
ZY05719_RS05375	COG2195	Cleaves the N-terminal amino acid of tripeptides
ZY05719_RS05410	COG3759	membrane
ZY05719_RS05415	COG1846	Transcriptional regulator
ZY05719_RS05430	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ZY05719_RS05435	COG2610	gluconate transmembrane transporter activity
ZY05719_RS05455	COG0302	gtp cyclohydrolase
ZY05719_RS05460	COG1051	belongs to the nudix hydrolase family
ZY05719_RS05485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ZY05719_RS05485	COG0072	phenylalanine-tRNA ligase activity
ZY05719_RS05515	COG1028	Short-chain dehydrogenase reductase Sdr
ZY05719_RS05520	COG1312	Catalyzes the dehydration of D-mannonate
ZY05719_RS05530	COG0800	Aldolase
ZY05719_RS05540	COG3250	beta-galactosidase activity
ZY05719_RS05550	COG2211	Major facilitator Superfamily
ZY05719_RS05565	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ZY05719_RS05575	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ZY05719_RS05580	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ZY05719_RS05585	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ZY05719_RS05590	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ZY05719_RS05595	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ZY05719_RS05600	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ZY05719_RS05605	COG0356	it plays a direct role in the translocation of protons across the membrane
ZY05719_RS05615	COG1597	lipid kinase activity
ZY05719_RS05625	COG0701	Predicted permease
ZY05719_RS05630	COG3689	TIGRFAM TIGR03943 family protein
ZY05719_RS05635	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ZY05719_RS05650	COG0552	protein localization to endoplasmic reticulum
ZY05719_RS05655	COG0561	phosphatase activity
ZY05719_RS05660	COG0561	phosphatase activity
ZY05719_RS05665	COG1196	nuclear chromosome segregation
ZY05719_RS05690	COG2826	transposase and inactivated derivatives, IS30 family
ZY05719_RS05705	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ZY05719_RS05710	COG0538	isocitrate dehydrogenase activity
ZY05719_RS05715	COG0372	Belongs to the citrate synthase family
ZY05719_RS05720	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ZY05719_RS05725	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ZY05719_RS05730	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ZY05719_RS05740	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ZY05719_RS05745	COG1609	Transcriptional regulator
ZY05719_RS05760	COG5492	domain, Protein
ZY05719_RS05765	COG5492	domain, Protein
ZY05719_RS05770	COG5492	domain, Protein
ZY05719_RS05780	COG3716	PTS system mannose fructose sorbose family IID component
ZY05719_RS05790	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ZY05719_RS05795	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ZY05719_RS05820	COG1028	Short-chain dehydrogenase reductase Sdr
ZY05719_RS05855	COG1476	TRANSCRIPTIONal
ZY05719_RS05880	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ZY05719_RS05890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ZY05719_RS05895	COG4122	O-methyltransferase activity
ZY05719_RS05920	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ZY05719_RS05920	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ZY05719_RS05930	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ZY05719_RS05935	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ZY05719_RS05940	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ZY05719_RS05945	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ZY05719_RS05950	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ZY05719_RS05950	COG1116	anion transmembrane transporter activity
ZY05719_RS05955	COG4120	Belongs to the binding-protein-dependent transport system permease family
ZY05719_RS05975	COG3684	Belongs to the aldolase LacD family
ZY05719_RS05985	COG3679	Belongs to the UPF0342 family
ZY05719_RS05990	COG0287	Prephenate dehydrogenase
ZY05719_RS05995	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ZY05719_RS06000	COG0710	3-dehydroquinate dehydratase activity
ZY05719_RS06005	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ZY05719_RS06010	COG1368	sulfuric ester hydrolase activity
ZY05719_RS06025	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ZY05719_RS06035	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ZY05719_RS06080	COG1216	Glycosyl transferase, family 2
ZY05719_RS06080	COG1442	glycosyl transferase family 8
ZY05719_RS06085	COG1442	glycosyl transferase family 8
ZY05719_RS06115	COG0463	Glycosyl transferase, family 2
ZY05719_RS06145	COG1091	dTDP-4-dehydrorhamnose reductase activity
ZY05719_RS06150	COG1088	dTDP-glucose 4,6-dehydratase activity
ZY05719_RS06165	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ZY05719_RS06175	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ZY05719_RS06180	COG2384	SAM-dependent methyltransferase
ZY05719_RS06195	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ZY05719_RS06210	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ZY05719_RS06210	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ZY05719_RS06215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ZY05719_RS06225	COG0300	oxidoreductase activity
ZY05719_RS06230	COG1234	tRNA 3'-trailer cleavage
ZY05719_RS06240	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ZY05719_RS06245	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ZY05719_RS06255	COG2807	transmembrane transport
ZY05719_RS06260	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ZY05719_RS06265	COG1702	phosphate starvation-inducible protein PhoH
ZY05719_RS06270	COG4479	Belongs to the UPF0346 family
ZY05719_RS06285	COG2996	Protein conserved in bacteria
ZY05719_RS06290	COG0233	cytoplasmic translational termination
ZY05719_RS06295	COG0528	UMP kinase activity
ZY05719_RS06300	COG2244	polysaccharide biosynthetic process
ZY05719_RS06305	COG0625	glutathione transferase activity
ZY05719_RS06330	COG0346	lactoylglutathione lyase activity
ZY05719_RS06335	COG0697	spore germination
ZY05719_RS06335	COG1674	ftsk spoiiie
ZY05719_RS06340	COG1621	beta-fructofuranosidase activity
ZY05719_RS06350	COG0395	ABC-type sugar transport system, permease component
ZY05719_RS06355	COG4209	transmembrane transport
ZY05719_RS06360	COG1609	Transcriptional regulator
ZY05719_RS06380	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ZY05719_RS06395	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ZY05719_RS06405	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ZY05719_RS06415	COG1181	Belongs to the D-alanine--D-alanine ligase family
ZY05719_RS06420	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ZY05719_RS06425	COG0768	penicillin binding
ZY05719_RS06435	COG0488	(ABC) transporter
ZY05719_RS06440	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ZY05719_RS06450	COG0745	RESPONSE REGULATOR receiver
ZY05719_RS06455	COG1126	abc transporter atp-binding protein
ZY05719_RS06460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ZY05719_RS06465	COG0765	amino acid transport
ZY05719_RS06470	COG0765	amino acid transport
ZY05719_RS06475	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ZY05719_RS06490	COG0438	transferase activity, transferring glycosyl groups
ZY05719_RS06505	COG1609	Transcriptional regulator
ZY05719_RS06515	COG0343	queuine tRNA-ribosyltransferase activity
ZY05719_RS06525	COG1832	CoA-binding protein
ZY05719_RS06535	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ZY05719_RS06535	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ZY05719_RS06550	COG1136	(ABC) transporter
ZY05719_RS06560	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ZY05719_RS06565	COG2217	Heavy metal translocating P-type atpase
ZY05719_RS06580	COG1063	alcohol dehydrogenase
ZY05719_RS06585	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ZY05719_RS06590	COG0557	exoribonuclease II activity
ZY05719_RS06600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ZY05719_RS06605	COG2814	Major facilitator Superfamily
ZY05719_RS06615	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ZY05719_RS06620	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ZY05719_RS06625	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ZY05719_RS06635	COG1737	Transcriptional regulator
ZY05719_RS06645	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
ZY05719_RS06655	COG1011	Hydrolase
ZY05719_RS06660	COG1132	(ABC) transporter
ZY05719_RS06665	COG1132	(ABC) transporter
ZY05719_RS06690	COG2177	Part of the ABC transporter FtsEX involved in
ZY05719_RS06695	COG2884	Cell division ATP-binding protein ftsE
ZY05719_RS06700	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ZY05719_RS06705	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ZY05719_RS06735	COG2826	transposase and inactivated derivatives, IS30 family
ZY05719_RS06765	COG2151	metal-sulfur cluster biosynthetic enzyme
ZY05719_RS06770	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ZY05719_RS06775	COG0358	DNA primase activity
ZY05719_RS06780	COG1970	mechanosensitive ion channel activity
ZY05719_RS06785	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ZY05719_RS06790	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ZY05719_RS06800	COG0647	UMP catabolic process
ZY05719_RS06805	COG1051	belongs to the nudix hydrolase family
ZY05719_RS06815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ZY05719_RS06825	COG0813	purine-nucleoside phosphorylase activity
ZY05719_RS06830	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ZY05719_RS06840	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ZY05719_RS06845	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ZY05719_RS06850	COG0732	type I restriction modification DNA specificity domain
ZY05719_RS06870	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ZY05719_RS06885	COG2268	Band 7 protein
ZY05719_RS06890	COG1704	LemA family
ZY05719_RS06900	COG1573	uracil-dna glycosylase
ZY05719_RS06935	COG2226	methyltransferase
ZY05719_RS06940	COG0488	(ABC) transporter
ZY05719_RS06945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ZY05719_RS06960	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ZY05719_RS06965	COG3442	glutamine amidotransferase
ZY05719_RS06970	COG2226	methyltransferase
ZY05719_RS06985	COG0488	(ABC) transporter
ZY05719_RS07020	COG3842	ATPase activity
ZY05719_RS07040	COG1263	PTS System
ZY05719_RS07040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ZY05719_RS07040	COG2190	(PTS) system
ZY05719_RS07045	COG3711	transcriptional antiterminator
ZY05719_RS07050	COG1293	RNA-binding protein homologous to eukaryotic snRNP
ZY05719_RS07055	COG3527	Alpha-acetolactate decarboxylase
ZY05719_RS07065	COG0628	permease
ZY05719_RS07070	COG2706	6-phosphogluconolactonase activity
ZY05719_RS07080	COG1011	Hydrolase
ZY05719_RS07120	COG0560	Phosphoserine phosphatase
ZY05719_RS07125	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
ZY05719_RS07130	COG0187	DNA topoisomerase II activity
ZY05719_RS07135	COG0693	protein deglycase activity
ZY05719_RS07140	COG0772	Belongs to the SEDS family
ZY05719_RS07145	COG0582	viral genome integration into host DNA
ZY05719_RS07230	COG0582	viral genome integration into host DNA
ZY05719_RS07245	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ZY05719_RS07250	COG0716	FMN binding
ZY05719_RS07260	COG1605	Chorismate mutase
ZY05719_RS07260	COG0287	Prephenate dehydrogenase
ZY05719_RS07265	COG0038	chloride channel
ZY05719_RS07275	COG0737	Belongs to the 5'-nucleotidase family
ZY05719_RS07280	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ZY05719_RS07285	COG1466	dna polymerase III delta subunit
ZY05719_RS07320	COG0683	leucine binding
ZY05719_RS07335	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ZY05719_RS07340	COG0366	Alpha amylase catalytic
ZY05719_RS07350	COG0395	ABC-type sugar transport system, permease component
ZY05719_RS07355	COG1175	transmembrane transport
ZY05719_RS07360	COG1653	transport
ZY05719_RS07370	COG2207	Transcriptional regulator
ZY05719_RS07375	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ZY05719_RS07380	COG0626	cystathionine gamma-synthase activity
ZY05719_RS07400	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ZY05719_RS07405	COG2827	Endonuclease containing a URI domain
ZY05719_RS07430	COG0640	Transcriptional regulator
ZY05719_RS07435	COG0513	Belongs to the DEAD box helicase family
ZY05719_RS07440	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ZY05719_RS07480	COG0494	nUDIX hydrolase
ZY05719_RS07485	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ZY05719_RS07500	COG1028	Short-chain dehydrogenase reductase Sdr
ZY05719_RS07530	COG0577	efflux transmembrane transporter activity
ZY05719_RS07535	COG1136	(ABC) transporter
ZY05719_RS07540	COG2205	protein histidine kinase activity
ZY05719_RS07555	COG0436	Aminotransferase
ZY05719_RS07565	COG1174	glycine betaine transport
ZY05719_RS07570	COG1125	glycine betaine transport
ZY05719_RS07570	COG0517	IMP dehydrogenase activity
ZY05719_RS07590	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ZY05719_RS07595	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ZY05719_RS07600	COG1482	cell wall glycoprotein biosynthetic process
ZY05719_RS07625	COG3091	SprT-like family
ZY05719_RS07635	COG0656	L-ascorbic acid biosynthetic process
ZY05719_RS07640	COG4708	membrane
ZY05719_RS07645	COG2246	polysaccharide biosynthetic process
ZY05719_RS07655	COG0024	Methionine aminopeptidase
ZY05719_RS07665	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ZY05719_RS07670	COG2249	NAD(P)H dehydrogenase (quinone) activity
ZY05719_RS07675	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ZY05719_RS07680	COG2131	deaminase
ZY05719_RS07690	COG1363	Peptidase, m42
ZY05719_RS07710	COG1956	GAF domain-containing protein
ZY05719_RS07720	COG1695	Transcriptional regulator
ZY05719_RS07735	COG0513	Belongs to the DEAD box helicase family
ZY05719_RS07740	COG0726	polysaccharide deacetylase
ZY05719_RS07760	COG0183	Belongs to the thiolase family
ZY05719_RS07765	COG3425	synthase
ZY05719_RS07795	COG0776	regulation of translation
ZY05719_RS07805	COG2755	lipolytic protein G-D-S-L family
ZY05719_RS07810	COG1307	EDD domain protein, DegV family
ZY05719_RS07815	COG0497	DNA recombination
ZY05719_RS07820	COG1438	arginine binding
ZY05719_RS07825	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ZY05719_RS07835	COG1722	exodeoxyribonuclease VII activity
ZY05719_RS07840	COG1570	exodeoxyribonuclease VII activity
ZY05719_RS07845	COG2321	neutral zinc metallopeptidase
ZY05719_RS07850	COG1755	Isoprenylcysteine carboxyl methyltransferase
ZY05719_RS07855	COG5002	protein histidine kinase activity
ZY05719_RS07860	COG0745	RESPONSE REGULATOR receiver
ZY05719_RS07885	COG1227	inorganic diphosphatase activity
ZY05719_RS07895	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ZY05719_RS07900	COG1253	flavin adenine dinucleotide binding
ZY05719_RS07905	COG1119	ATPase activity
ZY05719_RS07910	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ZY05719_RS07920	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ZY05719_RS07925	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ZY05719_RS07940	COG4470	Protein conserved in bacteria
ZY05719_RS07945	COG3480	Lon protease (S16) C-terminal proteolytic domain
ZY05719_RS07950	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ZY05719_RS07955	COG0742	ribosomal rna small subunit methyltransferase
ZY05719_RS07965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ZY05719_RS07970	COG4483	Protein conserved in bacteria
ZY05719_RS07975	COG2197	response regulator
ZY05719_RS07980	COG4585	Histidine kinase
ZY05719_RS07980	COG2203	Gaf domain
ZY05719_RS07985	COG0842	Transport permease protein
ZY05719_RS07990	COG1131	(ABC) transporter
ZY05719_RS08005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ZY05719_RS08020	COG0671	phosphoesterase, PA-phosphatase related
ZY05719_RS08025	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
ZY05719_RS08040	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ZY05719_RS08045	COG1187	pseudouridine synthase activity
ZY05719_RS08050	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ZY05719_RS08055	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ZY05719_RS08060	COG0582	viral genome integration into host DNA
ZY05719_RS08080	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ZY05719_RS08085	COG3763	UPF0154 protein
ZY05719_RS08095	COG3579	cysteine-type endopeptidase activity
ZY05719_RS08110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ZY05719_RS08115	COG1254	Belongs to the acylphosphatase family
ZY05719_RS08125	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ZY05719_RS08130	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ZY05719_RS08140	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ZY05719_RS08150	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ZY05719_RS08165	COG1160	GTP binding
ZY05719_RS08175	COG1484	DNA-dependent DNA replication
ZY05719_RS08185	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ZY05719_RS08190	COG0628	permease
ZY05719_RS08195	COG0745	RESPONSE REGULATOR receiver
ZY05719_RS08200	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ZY05719_RS08210	COG0492	ferredoxin-NADP+ reductase activity
ZY05719_RS08220	COG0513	Belongs to the DEAD box helicase family
ZY05719_RS08230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ZY05719_RS08235	COG0768	penicillin binding
ZY05719_RS08245	COG0275	rRNA processing
ZY05719_RS08295	COG4939	FMN-binding domain protein
ZY05719_RS08300	COG0142	geranyltranstransferase activity
ZY05719_RS08305	COG1252	NADH dehydrogenase
ZY05719_RS08320	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ZY05719_RS08325	COG0569	domain protein
ZY05719_RS08330	COG0534	Mate efflux family protein
ZY05719_RS08340	COG4224	UPF0291 protein
ZY05719_RS08345	COG0751	glycine-tRNA ligase activity
ZY05719_RS08370	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ZY05719_RS08375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ZY05719_RS08380	COG1464	Belongs to the NlpA lipoprotein family
ZY05719_RS08385	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ZY05719_RS08390	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ZY05719_RS08395	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ZY05719_RS08400	COG2252	PERMEase
ZY05719_RS08405	COG0561	phosphatase activity
ZY05719_RS08415	COG3715	PTS system
ZY05719_RS08420	COG3716	PTS system mannose fructose sorbose family IID component
ZY05719_RS08445	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ZY05719_RS08490	COG0439	Biotin carboxylase
ZY05719_RS08510	COG1028	Short-chain dehydrogenase reductase Sdr
ZY05719_RS08515	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ZY05719_RS08520	COG2070	2-Nitropropane dioxygenase
ZY05719_RS08530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ZY05719_RS08540	COG1024	Enoyl-CoA hydratase
ZY05719_RS08545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ZY05719_RS08550	COG0527	aspartate kinase activity
ZY05719_RS08560	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ZY05719_RS08565	COG0736	holo-[acyl-carrier-protein] synthase activity
ZY05719_RS08570	COG0653	protein targeting
ZY05719_RS08580	COG1940	carbohydrate kinase activity
ZY05719_RS08585	COG1263	PTS System
ZY05719_RS08585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ZY05719_RS08585	COG2190	(PTS) system
ZY05719_RS08590	COG1621	beta-fructofuranosidase activity
ZY05719_RS08595	COG1609	Transcriptional regulator
ZY05719_RS08600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ZY05719_RS08615	COG0006	proline dipeptidase activity
ZY05719_RS08620	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ZY05719_RS08640	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ZY05719_RS08645	COG0629	single-stranded DNA binding
ZY05719_RS08655	COG2826	transposase and inactivated derivatives, IS30 family
ZY05719_RS08660	COG0095	Lipoate-protein ligase
ZY05719_RS08675	COG0508	dehydrogenase complex catalyzes the overall conversion of
ZY05719_RS08680	COG0022	dehydrogenase e1 component
ZY05719_RS08680	COG0508	dehydrogenase complex catalyzes the overall conversion of
ZY05719_RS08685	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ZY05719_RS08690	COG2860	membrane
ZY05719_RS08705	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ZY05719_RS08710	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ZY05719_RS08720	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ZY05719_RS08725	COG0195	Participates in both transcription termination and antitermination
ZY05719_RS08735	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ZY05719_RS08745	COG4473	ABC transporter
ZY05719_RS08750	COG1131	(ABC) transporter
ZY05719_RS08755	COG0537	adenosine 5'-monophosphoramidase activity
ZY05719_RS08765	COG1316	TRANSCRIPTIONal
ZY05719_RS08775	COG0802	atpase or kinase
ZY05719_RS08780	COG1461	Dihydroxyacetone kinase
ZY05719_RS08795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ZY05719_RS08800	COG0601	transmembrane transport
ZY05719_RS08805	COG4608	Belongs to the ABC transporter superfamily
ZY05719_RS08820	COG1686	Belongs to the peptidase S11 family
ZY05719_RS08835	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ZY05719_RS08840	COG0719	Fe-S assembly protein
ZY05719_RS08850	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ZY05719_RS08855	COG4862	establishment of competence for transformation
ZY05719_RS08860	COG1968	undecaprenyl-diphosphatase activity
ZY05719_RS08865	COG0765	amino acid transport
ZY05719_RS08885	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ZY05719_RS08890	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ZY05719_RS08895	COG0440	acetolactate synthase activity
ZY05719_RS08900	COG0028	Belongs to the TPP enzyme family
ZY05719_RS08920	COG0129	dihydroxy-acid dehydratase activity
ZY05719_RS08930	COG2151	metal-sulfur cluster biosynthetic enzyme
ZY05719_RS08950	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ZY05719_RS08965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ZY05719_RS08990	COG3842	ATPase activity
ZY05719_RS09000	COG2207	Transcriptional regulator
ZY05719_RS09000	COG4753	response regulator
ZY05719_RS09005	COG2972	Histidine kinase
ZY05719_RS09020	COG1653	transport
ZY05719_RS09025	COG0395	ABC-type sugar transport system, permease component
ZY05719_RS09030	COG1175	transmembrane transport
ZY05719_RS09045	COG0383	alpha-mannosidase activity
ZY05719_RS09065	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
ZY05719_RS09085	COG1045	serine acetyltransferase
ZY05719_RS09090	COG1185	polyribonucleotide nucleotidyltransferase activity
ZY05719_RS09110	COG1263	PTS System
ZY05719_RS09110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ZY05719_RS09120	COG1737	Transcriptional regulator
ZY05719_RS09125	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ZY05719_RS09145	COG1187	pseudouridine synthase activity
ZY05719_RS09165	COG0242	peptide deformylase activity
ZY05719_RS09175	COG0066	3-isopropylmalate dehydratase activity
ZY05719_RS09200	COG2309	aminopeptidase activity
ZY05719_RS09215	COG2176	DNA-directed DNA polymerase activity
ZY05719_RS09220	COG2376	Dihydroxyacetone kinase
ZY05719_RS09230	COG2376	Dihydroxyacetone kinase
ZY05719_RS09235	COG1461	Dihydroxyacetone kinase
ZY05719_RS09240	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ZY05719_RS09245	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ZY05719_RS09250	COG0442	prolyl-tRNA aminoacylation
ZY05719_RS09260	COG4589	Belongs to the CDS family
ZY05719_RS09265	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ZY05719_RS09270	COG1862	Preprotein translocase
ZY05719_RS09280	COG1181	Belongs to the D-alanine--D-alanine ligase family
ZY05719_RS09280	COG2918	glutathione biosynthetic process
ZY05719_RS09290	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ZY05719_RS09295	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ZY05719_RS09305	COG3201	nicotinamide mononucleotide transporter
ZY05719_RS09310	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ZY05719_RS09320	COG4463	regulation of RNA biosynthetic process
ZY05719_RS09335	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ZY05719_RS09370	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ZY05719_RS09375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ZY05719_RS09380	COG0492	ferredoxin-NADP+ reductase activity
ZY05719_RS09385	COG0564	pseudouridine synthase activity
ZY05719_RS09390	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ZY05719_RS09410	COG1564	THIamine pyrophosphokinase
ZY05719_RS09420	COG1162	GTPase activity
ZY05719_RS09470	COG4115	mRNA cleavage
ZY05719_RS09505	COG0084	hydrolase, TatD family'
ZY05719_RS09515	COG1847	R3H domain protein
ZY05719_RS09525	COG0594	ribonuclease P activity
ZY05719_RS09530	COG0165	Argininosuccinate lyase
ZY05719_RS09535	COG0137	argininosuccinate synthase activity
ZY05719_RS09545	COG1827	regulation of RNA biosynthetic process
ZY05719_RS09560	COG2040	homocysteine
ZY05719_RS09565	COG0833	amino acid
ZY05719_RS09610	COG0756	dUTP diphosphatase activity
ZY05719_RS09615	COG1132	(ABC) transporter
ZY05719_RS09620	COG1132	(ABC) transporter
ZY05719_RS09630	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ZY05719_RS09635	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ZY05719_RS09640	COG0705	Rhomboid family
ZY05719_RS09645	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ZY05719_RS09650	COG1473	amidohydrolase
ZY05719_RS09655	COG2171	N-acyltransferase activity
ZY05719_RS09670	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ZY05719_RS09690	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ZY05719_RS09715	COG3623	hexulose-6-phosphate isomerase
ZY05719_RS09745	COG1609	Transcriptional regulator
ZY05719_RS09750	COG1126	abc transporter atp-binding protein
ZY05719_RS09755	COG0765	amino acid transport
ZY05719_RS09760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ZY05719_RS09765	COG3942	CHAP domain
ZY05719_RS09770	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ZY05719_RS09780	COG1447	Phosphotransferase system cellobiose-specific component IIA
ZY05719_RS09790	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ZY05719_RS09790	COG3711	transcriptional antiterminator
ZY05719_RS09800	COG2723	6-phospho-beta-galactosidase activity
ZY05719_RS09805	COG1486	melibiose metabolic process
ZY05719_RS09815	COG3590	peptidase
ZY05719_RS09820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ZY05719_RS09825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ZY05719_RS09825	COG1321	iron dependent repressor
ZY05719_RS09830	COG1121	(ABC) transporter
ZY05719_RS09840	COG0803	Belongs to the bacterial solute-binding protein 9 family
ZY05719_RS09875	COG1490	D-aminoacyl-tRNA deacylase activity
ZY05719_RS09885	COG0737	Belongs to the 5'-nucleotidase family
ZY05719_RS09940	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ZY05719_RS09965	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ZY05719_RS09990	COG0737	Belongs to the 5'-nucleotidase family
ZY05719_RS10000	COG1328	CTP reductase activity
ZY05719_RS10030	COG1438	arginine binding
ZY05719_RS10035	COG0018	arginyl-trna synthetase
ZY05719_RS10055	COG1640	4-alpha-glucanotransferase
ZY05719_RS10060	COG2182	Extracellular solute-binding protein
ZY05719_RS10065	COG1175	transmembrane transport
ZY05719_RS10070	COG3833	ABC-type maltose transport systems, permease component
ZY05719_RS10075	COG5521	maltodextrose utilization protein MalA
ZY05719_RS10080	COG1609	Transcriptional regulator
ZY05719_RS10085	COG1523	belongs to the glycosyl hydrolase 13 family
ZY05719_RS10090	COG1780	Probably involved in ribonucleotide reductase function
ZY05719_RS10095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ZY05719_RS10100	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ZY05719_RS10105	COG2153	protein acetylation
ZY05719_RS10110	COG4989	oxidoreductase activity
ZY05719_RS10115	COG1216	Glycosyl transferase, family 2
ZY05719_RS10120	COG1472	Belongs to the glycosyl hydrolase 3 family
ZY05719_RS10160	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ZY05719_RS10175	COG0305	Participates in initiation and elongation during chromosome replication
ZY05719_RS10180	COG0359	binds to the 23S rRNA
ZY05719_RS10190	COG0445	tRNA wobble uridine modification
ZY05719_RS10205	COG1051	belongs to the nudix hydrolase family
ZY05719_RS10210	COG1733	regulation of RNA biosynthetic process
ZY05719_RS10220	COG0482	sulfurtransferase activity
ZY05719_RS10225	COG1760	l-serine dehydratase
ZY05719_RS10230	COG1760	l-serine dehydratase
ZY05719_RS10240	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ZY05719_RS10245	COG1122	ATPase activity
ZY05719_RS10250	COG1122	ATPase activity
ZY05719_RS10255	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ZY05719_RS10260	COG1426	Protein conserved in bacteria
ZY05719_RS10265	COG0612	Peptidase, M16
ZY05719_RS10270	COG0612	Peptidase, M16
ZY05719_RS10280	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ZY05719_RS10285	COG0517	IMP dehydrogenase activity
ZY05719_RS10285	COG0516	GMP reductase activity
ZY05719_RS10295	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ZY05719_RS10300	COG0488	(ABC) transporter
ZY05719_RS10330	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ZY05719_RS10335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ZY05719_RS10340	COG1475	DNA binding
ZY05719_RS10350	COG0582	viral genome integration into host DNA