locus-tag	class	description
IBB96_RS00010	COG0592	DNA-directed DNA polymerase activity
IBB96_RS00020	COG0012	GTP binding
IBB96_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IBB96_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IBB96_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IBB96_RS00195	COG3942	CHAP domain
IBB96_RS00210	COG0436	Aminotransferase
IBB96_RS00225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IBB96_RS00235	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IBB96_RS00250	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IBB96_RS00265	COG1388	LysM domain
IBB96_RS00265	COG3942	CHAP domain
IBB96_RS00270	COG0151	Belongs to the GarS family
IBB96_RS00275	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IBB96_RS00295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IBB96_RS00360	COG4550	Control of competence regulator ComK, YlbF/YmcA
IBB96_RS00400	COG2818	Glycosylase
IBB96_RS00415	COG1393	Belongs to the ArsC family
IBB96_RS00505	COG2309	aminopeptidase activity
IBB96_RS00520	COG0431	NADPH-dependent FMN reductase
IBB96_RS00555	COG4463	regulation of RNA biosynthetic process
IBB96_RS00560	COG0542	response to heat
IBB96_RS00570	COG1686	Belongs to the peptidase S11 family
IBB96_RS00585	COG1045	serine acetyltransferase
IBB96_RS00595	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
IBB96_RS00610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IBB96_RS00635	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IBB96_RS00695	COG1705	Flagellar rod assembly protein muramidase FlgJ
IBB96_RS00695	COG3942	CHAP domain
IBB96_RS00710	COG3830	Belongs to the UPF0237 family
IBB96_RS00725	COG1876	peptidase activity
IBB96_RS00760	COG0351	phosphomethylpyrimidine kinase
IBB96_RS00870	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IBB96_RS00890	COG0668	transmembrane transport
IBB96_RS00905	COG0504	CTP synthase activity
IBB96_RS00915	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IBB96_RS00925	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IBB96_RS00930	COG0737	Belongs to the 5'-nucleotidase family
IBB96_RS00980	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IBB96_RS01015	COG1126	abc transporter atp-binding protein
IBB96_RS01020	COG0765	amino acid transport
IBB96_RS01025	COG1968	undecaprenyl-diphosphatase activity
IBB96_RS01035	COG4862	establishment of competence for transformation
IBB96_RS01040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IBB96_RS01050	COG0719	Fe-S assembly protein
IBB96_RS01055	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IBB96_RS01065	COG0719	Fe-S assembly protein
IBB96_RS01105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IBB96_RS01130	COG1121	(ABC) transporter
IBB96_RS01135	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IBB96_RS01175	COG4589	Belongs to the CDS family
IBB96_RS01190	COG4120	Belongs to the binding-protein-dependent transport system permease family
IBB96_RS01195	COG1116	anion transmembrane transporter activity
IBB96_RS01195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IBB96_RS01230	COG0564	pseudouridine synthase activity
IBB96_RS01235	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IBB96_RS01285	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IBB96_RS01300	COG3579	cysteine-type endopeptidase activity
IBB96_RS01310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IBB96_RS01335	COG0116	Belongs to the methyltransferase superfamily
IBB96_RS01345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IBB96_RS01365	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IBB96_RS01385	COG1254	Belongs to the acylphosphatase family
IBB96_RS01390	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IBB96_RS01430	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IBB96_RS01450	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IBB96_RS01455	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IBB96_RS01460	COG1187	pseudouridine synthase activity
IBB96_RS01470	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IBB96_RS01475	COG0569	domain protein
IBB96_RS01485	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
IBB96_RS01490	COG0671	phosphoesterase, PA-phosphatase related
IBB96_RS01510	COG2274	protein secretion by the type I secretion system
IBB96_RS01520	COG2274	protein secretion by the type I secretion system
IBB96_RS01570	COG0829	nickel cation binding
IBB96_RS01575	COG0310	cobalt ion transport
IBB96_RS01585	COG1122	ATPase activity
IBB96_RS01590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBB96_RS01595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IBB96_RS01615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBB96_RS01620	COG1464	Belongs to the NlpA lipoprotein family
IBB96_RS01645	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IBB96_RS01655	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
IBB96_RS01670	COG1122	ATPase activity
IBB96_RS01680	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IBB96_RS01690	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IBB96_RS01705	COG0745	RESPONSE REGULATOR receiver
IBB96_RS01710	COG5002	protein histidine kinase activity
IBB96_RS01725	COG1484	DNA-dependent DNA replication
IBB96_RS01770	COG3716	PTS system mannose fructose sorbose family IID component
IBB96_RS01775	COG3715	PTS system
IBB96_RS01785	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IBB96_RS01790	COG0561	phosphatase activity
IBB96_RS01795	COG2252	PERMEase
IBB96_RS01800	COG0802	atpase or kinase
IBB96_RS01805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IBB96_RS01810	COG1316	TRANSCRIPTIONal
IBB96_RS01820	COG0195	Participates in both transcription termination and antitermination
IBB96_RS01825	COG2740	Nucleic-acid-binding protein implicated in transcription termination
IBB96_RS01860	COG2244	polysaccharide biosynthetic process
IBB96_RS01865	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IBB96_RS01870	COG0626	cystathionine gamma-synthase activity
IBB96_RS01875	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IBB96_RS01905	COG4471	UPF0298 protein
IBB96_RS01915	COG0559	Belongs to the binding-protein-dependent transport system permease family
IBB96_RS01945	COG1739	Uncharacterized protein family UPF0029
IBB96_RS01950	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
IBB96_RS01955	COG1040	competence protein
IBB96_RS02045	COG0527	aspartate kinase activity
IBB96_RS02050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IBB96_RS02055	COG1024	Enoyl-CoA hydratase
IBB96_RS02060	COG1846	Transcriptional regulator
IBB96_RS02080	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IBB96_RS02085	COG1028	Short-chain dehydrogenase reductase Sdr
IBB96_RS02090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IBB96_RS02105	COG0439	Biotin carboxylase
IBB96_RS02130	COG0076	glutamate decarboxylase activity
IBB96_RS02135	COG0531	amino acid
IBB96_RS02215	COG1349	DNA-binding transcription factor activity
IBB96_RS02220	COG1105	Belongs to the carbohydrate kinase PfkB family
IBB96_RS02230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IBB96_RS02235	COG0285	dihydrofolate synthase activity
IBB96_RS02245	COG1104	cysteine desulfurase activity
IBB96_RS02305	COG0488	(ABC) transporter
IBB96_RS02325	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IBB96_RS02330	COG0242	peptide deformylase activity
IBB96_RS02385	COG1702	phosphate starvation-inducible protein PhoH
IBB96_RS02415	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IBB96_RS02415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IBB96_RS02435	COG4122	O-methyltransferase activity
IBB96_RS02440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IBB96_RS02475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IBB96_RS02480	COG0436	Aminotransferase
IBB96_RS02495	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IBB96_RS02500	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IBB96_RS02505	COG0726	polysaccharide deacetylase
IBB96_RS02520	COG2962	Rard protein
IBB96_RS02555	COG0356	it plays a direct role in the translocation of protons across the membrane
IBB96_RS02590	COG0772	Belongs to the SEDS family
IBB96_RS02610	COG0470	DNA polymerase III
IBB96_RS02615	COG1774	PSP1 C-terminal conserved region
IBB96_RS02620	COG4467	Involved in initiation control of chromosome replication
IBB96_RS02630	COG0004	ammonium transporteR
IBB96_RS02635	COG0347	Belongs to the P(II) protein family
IBB96_RS02640	COG1388	LysM domain
IBB96_RS02640	COG1705	Flagellar rod assembly protein muramidase FlgJ
IBB96_RS02685	COG1113	amino acid transport
IBB96_RS02725	COG0583	DNA-binding transcription factor activity
IBB96_RS02735	COG0564	pseudouridine synthase activity
IBB96_RS02755	COG0505	Belongs to the CarA family
IBB96_RS02800	COG1132	(ABC) transporter
IBB96_RS02805	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IBB96_RS02820	COG3279	Response regulator of the LytR AlgR family
IBB96_RS02830	COG1131	(ABC) transporter
IBB96_RS02865	COG1187	pseudouridine synthase activity
IBB96_RS02870	COG1473	amidohydrolase
IBB96_RS02875	COG0686	Belongs to the AlaDH PNT family
IBB96_RS02880	COG0686	Belongs to the AlaDH PNT family
IBB96_RS02885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IBB96_RS02955	COG0438	transferase activity, transferring glycosyl groups
IBB96_RS02990	COG1272	protein, Hemolysin III
IBB96_RS03005	COG3425	synthase
IBB96_RS03015	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IBB96_RS03035	COG0833	amino acid
IBB96_RS03040	COG2040	homocysteine
IBB96_RS03060	COG0187	DNA topoisomerase II activity
IBB96_RS03070	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IBB96_RS03090	COG0539	negative regulation of cytoplasmic translation
IBB96_RS03130	COG0494	nUDIX hydrolase
IBB96_RS03135	COG0542	response to heat
IBB96_RS03140	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IBB96_RS03145	COG4703	Protein of unknown function (DUF1797)
IBB96_RS03150	COG0765	amino acid transport
IBB96_RS03205	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IBB96_RS03210	COG0768	penicillin binding
IBB96_RS03215	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IBB96_RS03230	COG3711	transcriptional antiterminator
IBB96_RS03240	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IBB96_RS03245	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IBB96_RS03250	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IBB96_RS03255	COG0237	dephospho-CoA kinase activity
IBB96_RS03260	COG2814	Major facilitator Superfamily
IBB96_RS03275	COG0557	exoribonuclease II activity
IBB96_RS03290	COG1185	polyribonucleotide nucleotidyltransferase activity
IBB96_RS03295	COG0006	proline dipeptidase activity
IBB96_RS03300	COG1609	Transcriptional regulator
IBB96_RS03335	COG1368	sulfuric ester hydrolase activity
IBB96_RS03340	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IBB96_RS03365	COG0287	Prephenate dehydrogenase
IBB96_RS03390	COG0077	Prephenate dehydratase
IBB96_RS03450	COG1518	maintenance of DNA repeat elements
IBB96_RS03455	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IBB96_RS03465	COG3689	TIGRFAM TIGR03943 family protein
IBB96_RS03470	COG0701	Predicted permease
IBB96_RS03475	COG2183	response to ionizing radiation
IBB96_RS03520	COG0826	peptidase U32
IBB96_RS03530	COG1268	BioY protein
IBB96_RS03540	COG4443	Transcriptional Coactivator p15 (PC4)
IBB96_RS03545	COG1914	H( )-stimulated, divalent metal cation uptake system
IBB96_RS03605	COG0406	alpha-ribazole phosphatase activity
IBB96_RS03610	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IBB96_RS03660	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IBB96_RS03670	COG0732	type I restriction modification DNA specificity domain
IBB96_RS03705	COG1704	LemA family
IBB96_RS03710	COG0501	Belongs to the peptidase M48B family
IBB96_RS03735	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IBB96_RS03750	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IBB96_RS03755	COG0783	Belongs to the Dps family
IBB96_RS03760	COG0735	belongs to the Fur family
IBB96_RS03765	COG4483	Protein conserved in bacteria
IBB96_RS03770	COG1940	carbohydrate kinase activity
IBB96_RS03775	COG1217	gtp-binding protein TYPA
IBB96_RS03810	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IBB96_RS03835	COG3599	regulation of cell shape
IBB96_RS03865	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IBB96_RS03870	COG0625	glutathione transferase activity
IBB96_RS03890	COG2890	protein-(glutamine-N5) methyltransferase activity
IBB96_RS03920	COG1132	(ABC) transporter
IBB96_RS03935	COG1696	Membrane protein involved in D-alanine export
IBB96_RS03945	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
IBB96_RS03960	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IBB96_RS03965	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IBB96_RS03985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IBB96_RS03990	COG4684	Psort location CytoplasmicMembrane, score
IBB96_RS03995	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IBB96_RS04020	COG5002	protein histidine kinase activity
IBB96_RS04045	COG2813	Specifically methylates the guanine in position
IBB96_RS04065	COG1744	ABC transporter substrate-binding protein PnrA-like
IBB96_RS04070	COG3845	ABC transporter
IBB96_RS04075	COG4603	Belongs to the binding-protein-dependent transport system permease family
IBB96_RS04080	COG1079	Belongs to the binding-protein-dependent transport system permease family
IBB96_RS04090	COG1199	ATP-dependent helicase activity
IBB96_RS04090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IBB96_RS04100	COG0436	Aminotransferase
IBB96_RS04105	COG0017	Asparaginyl-tRNA synthetase
IBB96_RS04120	COG0251	oxidation-reduction process
IBB96_RS04130	COG0720	synthase
IBB96_RS04180	COG1278	Cold shock
IBB96_RS04195	COG2217	Heavy metal translocating P-type atpase
IBB96_RS04210	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IBB96_RS04215	COG0626	cystathionine gamma-synthase activity
IBB96_RS04220	COG1045	serine acetyltransferase
IBB96_RS04245	COG4975	Glucose uptake
IBB96_RS04265	COG3443	Belongs to the bacterial solute-binding protein 9 family
IBB96_RS04265	COG0803	Belongs to the bacterial solute-binding protein 9 family
IBB96_RS04290	COG3942	CHAP domain
IBB96_RS04290	COG1705	Flagellar rod assembly protein muramidase FlgJ
IBB96_RS04305	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IBB96_RS04310	COG2824	Alkylphosphonate utilization operon protein PhnA
IBB96_RS04315	COG0765	amino acid transport
IBB96_RS04320	COG1126	abc transporter atp-binding protein
IBB96_RS04325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBB96_RS04335	COG1064	alcohol dehydrogenase
IBB96_RS04340	COG1064	alcohol dehydrogenase
IBB96_RS04345	COG3421	Type III restriction
IBB96_RS04350	COG2189	Belongs to the N(4) N(6)-methyltransferase family
IBB96_RS04355	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IBB96_RS04355	COG0519	Catalyzes the synthesis of GMP from XMP
IBB96_RS04360	COG2188	Transcriptional regulator
IBB96_RS04370	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IBB96_RS04380	COG1827	regulation of RNA biosynthetic process
IBB96_RS04390	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IBB96_RS04400	COG1940	carbohydrate kinase activity
IBB96_RS04405	COG0758	DNA mediated transformation
IBB96_RS04410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IBB96_RS04460	COG0481	GTPase activity
IBB96_RS04465	COG1396	sequence-specific DNA binding
IBB96_RS04485	COG0010	Belongs to the arginase family
IBB96_RS04495	COG0028	Belongs to the TPP enzyme family
IBB96_RS04500	COG3527	Alpha-acetolactate decarboxylase
IBB96_RS04525	COG1230	cation diffusion facilitator family transporter
IBB96_RS04535	COG1063	alcohol dehydrogenase
IBB96_RS04555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IBB96_RS04570	COG1293	RNA-binding protein homologous to eukaryotic snRNP
IBB96_RS04625	COG0047	phosphoribosylformylglycinamidine synthase activity
IBB96_RS04635	COG0167	dihydroorotate dehydrogenase activity
IBB96_RS04645	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IBB96_RS04665	COG1337	RAMP superfamily
IBB96_RS04670	COG1567	CRISPR-associated RAMP protein, Csm4 family
IBB96_RS04685	COG0284	orotidine-5'-phosphate decarboxylase activity
IBB96_RS04700	COG3104	oligopeptide transport
IBB96_RS04705	COG0154	amidase activity
IBB96_RS04710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBB96_RS04715	COG0765	amino acid transport
IBB96_RS04735	COG1115	amino acid carrier protein
IBB96_RS04740	COG0210	DNA helicase
IBB96_RS04745	COG2873	o-acetylhomoserine
IBB96_RS04780	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IBB96_RS04785	COG0196	riboflavin kinase activity
IBB96_RS04790	COG1393	Belongs to the ArsC family
IBB96_RS04800	COG0483	inositol monophosphate 1-phosphatase activity
IBB96_RS04805	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
IBB96_RS04805	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IBB96_RS04815	COG0573	inorganic phosphate transmembrane transporter activity
IBB96_RS04820	COG0581	inorganic phosphate transmembrane transporter activity
IBB96_RS04835	COG0704	Plays a role in the regulation of phosphate uptake
IBB96_RS04850	COG0095	Lipoate-protein ligase
IBB96_RS04865	COG0058	SHG alpha-glucan phosphorylase activity
IBB96_RS04870	COG1640	4-alpha-glucanotransferase
IBB96_RS04880	COG1609	Transcriptional regulator
IBB96_RS04910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IBB96_RS04915	COG0805	protein transport
IBB96_RS04920	COG0672	)-iron permease
IBB96_RS04925	COG2837	iron assimilation
IBB96_RS04930	COG2822	iron ion transport
IBB96_RS04935	COG4607	ABC-type enterochelin transport system periplasmic component
IBB96_RS04940	COG4604	ABC transporter, ATP-binding protein
IBB96_RS04945	COG4605	iron ion homeostasis
IBB96_RS04950	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IBB96_RS04970	COG0508	dehydrogenase complex catalyzes the overall conversion of
IBB96_RS04975	COG0022	dehydrogenase e1 component
IBB96_RS04975	COG0508	dehydrogenase complex catalyzes the overall conversion of
IBB96_RS04980	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IBB96_RS05005	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IBB96_RS05010	COG4667	esterase of the alpha-beta hydrolase superfamily
IBB96_RS05050	COG0628	permease
IBB96_RS05060	COG0561	phosphatase activity
IBB96_RS05090	COG1442	glycosyl transferase family 8
IBB96_RS05090	COG1216	Glycosyl transferase, family 2
IBB96_RS05095	COG1442	glycosyl transferase family 8
IBB96_RS05095	COG1216	Glycosyl transferase, family 2
IBB96_RS05115	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IBB96_RS05135	COG2244	polysaccharide biosynthetic process
IBB96_RS05145	COG1216	Glycosyl transferase, family 2
IBB96_RS05145	COG1442	glycosyl transferase family 8
IBB96_RS05150	COG1442	glycosyl transferase family 8
IBB96_RS05200	COG1316	TRANSCRIPTIONal
IBB96_RS05220	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IBB96_RS05230	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IBB96_RS05250	COG1573	uracil-dna glycosylase
IBB96_RS05315	COG0681	Belongs to the peptidase S26 family
IBB96_RS05325	COG0628	permease
IBB96_RS05330	COG1051	belongs to the nudix hydrolase family
IBB96_RS05335	COG2177	Part of the ABC transporter FtsEX involved in
IBB96_RS05340	COG2884	Cell division ATP-binding protein ftsE
IBB96_RS05350	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IBB96_RS05385	COG2348	transferase activity, transferring amino-acyl groups
IBB96_RS05395	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IBB96_RS05400	COG5002	protein histidine kinase activity
IBB96_RS05405	COG0745	RESPONSE REGULATOR receiver
IBB96_RS05410	COG1126	abc transporter atp-binding protein
IBB96_RS05415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBB96_RS05420	COG0765	amino acid transport
IBB96_RS05425	COG0765	amino acid transport
IBB96_RS05450	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IBB96_RS05460	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IBB96_RS05465	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IBB96_RS05465	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IBB96_RS05475	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IBB96_RS05480	COG1956	GAF domain-containing protein
IBB96_RS05485	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IBB96_RS05500	COG0335	large ribosomal subunit rRNA binding
IBB96_RS05505	COG0038	chloride channel
IBB96_RS05515	COG0038	chloride channel
IBB96_RS05520	COG0716	FMN binding
IBB96_RS05585	COG3328	transposase activity
IBB96_RS05595	COG0469	pyruvate kinase activity
IBB96_RS05645	COG0167	dihydroorotate dehydrogenase activity
IBB96_RS05655	COG0776	regulation of translation
IBB96_RS05665	COG2755	lipolytic protein G-D-S-L family
IBB96_RS05670	COG1307	EDD domain protein, DegV family
IBB96_RS05675	COG0497	DNA recombination
IBB96_RS05680	COG1438	arginine binding
IBB96_RS05685	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
IBB96_RS05710	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IBB96_RS05720	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IBB96_RS05730	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IBB96_RS05730	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IBB96_RS05735	COG0300	oxidoreductase activity
IBB96_RS05750	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IBB96_RS05755	COG0772	Belongs to the SEDS family
IBB96_RS05770	COG0107	imidazoleglycerol-phosphate synthase activity
IBB96_RS05780	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IBB96_RS05790	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IBB96_RS05835	COG0647	UMP catabolic process
IBB96_RS05845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IBB96_RS05865	COG1088	dTDP-glucose 4,6-dehydratase activity
IBB96_RS05875	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IBB96_RS05880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IBB96_RS05895	COG2384	SAM-dependent methyltransferase
IBB96_RS05920	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IBB96_RS05925	COG3442	glutamine amidotransferase
IBB96_RS05930	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IBB96_RS05930	COG0392	lysyltransferase activity
IBB96_RS05940	COG0488	(ABC) transporter
IBB96_RS05950	COG0513	Belongs to the DEAD box helicase family
IBB96_RS05985	COG0372	Belongs to the citrate synthase family
IBB96_RS05990	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IBB96_RS05995	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IBB96_RS06000	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IBB96_RS06005	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IBB96_RS06030	COG0346	lactoylglutathione lyase activity
IBB96_RS06035	COG3764	Sortase (surface protein transpeptidase)
IBB96_RS06055	COG0488	(ABC) transporter
IBB96_RS06080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IBB96_RS06085	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IBB96_RS06085	COG1328	CTP reductase activity
IBB96_RS06105	COG1196	nuclear chromosome segregation
IBB96_RS06120	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IBB96_RS06135	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IBB96_RS06145	COG1011	Hydrolase
IBB96_RS06155	COG1760	l-serine dehydratase
IBB96_RS06160	COG1760	l-serine dehydratase
IBB96_RS06185	COG2197	response regulator
IBB96_RS06190	COG4585	Histidine kinase
IBB96_RS06200	COG1131	(ABC) transporter
IBB96_RS06235	COG3328	transposase activity
IBB96_RS06265	COG0577	efflux transmembrane transporter activity
IBB96_RS06270	COG1136	(ABC) transporter
IBB96_RS06275	COG0784	Response regulator, receiver
IBB96_RS06275	COG2198	Histidine kinase
IBB96_RS06275	COG5002	protein histidine kinase activity
IBB96_RS06280	COG0745	RESPONSE REGULATOR receiver
IBB96_RS06295	COG0534	Mate efflux family protein
IBB96_RS06300	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IBB96_RS06300	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IBB96_RS06315	COG1126	abc transporter atp-binding protein
IBB96_RS06320	COG0765	amino acid transport
IBB96_RS06330	COG2079	MmgE PrpD family protein
IBB96_RS06335	COG0436	Aminotransferase
IBB96_RS06370	COG0531	amino acid
IBB96_RS06390	COG1126	abc transporter atp-binding protein
IBB96_RS06395	COG0765	amino acid transport
IBB96_RS06400	COG0765	amino acid transport
IBB96_RS06405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBB96_RS06415	COG0386	Belongs to the glutathione peroxidase family
IBB96_RS06450	COG2514	catechol 2,3-dioxygenase activity
IBB96_RS06455	COG1959	2 iron, 2 sulfur cluster binding
IBB96_RS06465	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IBB96_RS06465	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IBB96_RS06470	COG0778	Nitroreductase
IBB96_RS06480	COG0656	L-ascorbic acid biosynthetic process
IBB96_RS06485	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IBB96_RS06520	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IBB96_RS06545	COG1280	lysine exporter protein (LysE YggA)
IBB96_RS06560	COG1216	Glycosyl transferase, family 2
IBB96_RS06560	COG1442	glycosyl transferase family 8
IBB96_RS06565	COG0577	efflux transmembrane transporter activity
IBB96_RS06620	COG1396	sequence-specific DNA binding
IBB96_RS06640	COG0419	ATPase involved in DNA repair
IBB96_RS06645	COG0420	3'-5' exonuclease activity
IBB96_RS06655	COG3250	beta-galactosidase activity
IBB96_RS06660	COG2211	Major facilitator Superfamily
IBB96_RS06660	COG2190	(PTS) system
IBB96_RS06665	COG2017	converts alpha-aldose to the beta-anomer
IBB96_RS06670	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IBB96_RS06685	COG1609	Transcriptional regulator
IBB96_RS06710	COG0488	(ABC) transporter
IBB96_RS06775	COG2197	response regulator
IBB96_RS06780	COG4585	Histidine kinase
IBB96_RS06795	COG0515	serine threonine protein kinase
IBB96_RS06795	COG2815	serine threonine protein kinase
IBB96_RS06805	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IBB96_RS06805	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IBB96_RS06815	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IBB96_RS06830	COG0552	protein localization to endoplasmic reticulum
IBB96_RS06835	COG0561	phosphatase activity
IBB96_RS06840	COG0561	phosphatase activity
IBB96_RS06845	COG1725	Transcriptional regulator
IBB96_RS06850	COG1131	(ABC) transporter
IBB96_RS06860	COG4608	Belongs to the ABC transporter superfamily
IBB96_RS06865	COG0444	Belongs to the ABC transporter superfamily
IBB96_RS06870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IBB96_RS06875	COG0601	transmembrane transport
IBB96_RS06880	COG4166	transmembrane transport
IBB96_RS06890	COG4166	transmembrane transport
IBB96_RS06905	COG4608	Belongs to the ABC transporter superfamily
IBB96_RS06910	COG4608	Belongs to the ABC transporter superfamily
IBB96_RS06915	COG0084	hydrolase, TatD family'
IBB96_RS06920	COG2223	nitrite transmembrane transporter activity
IBB96_RS06930	COG0280	phosphate acetyltransferase
IBB96_RS06935	COG0564	pseudouridine synthase activity
IBB96_RS06945	COG2357	RelA SpoT domain protein
IBB96_RS06960	COG1104	cysteine desulfurase activity
IBB96_RS06980	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IBB96_RS06985	COG2003	Belongs to the UPF0758 family
IBB96_RS07010	COG1215	transferase activity, transferring glycosyl groups
IBB96_RS07020	COG1216	Glycosyl transferase, family 2
IBB96_RS07020	COG1442	glycosyl transferase family 8
IBB96_RS07040	COG1091	dTDP-4-dehydrorhamnose reductase activity
IBB96_RS07050	COG0463	Glycosyl transferase, family 2
IBB96_RS07060	COG2151	metal-sulfur cluster biosynthetic enzyme
IBB96_RS07065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IBB96_RS07070	COG0358	DNA primase activity
IBB96_RS07085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBB96_RS07090	COG0436	Aminotransferase
IBB96_RS07095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBB96_RS07100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBB96_RS07105	COG1051	belongs to the nudix hydrolase family
IBB96_RS07125	COG0765	amino acid transport
IBB96_RS07130	COG1126	abc transporter atp-binding protein
IBB96_RS07150	COG1187	pseudouridine synthase activity
IBB96_RS07190	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IBB96_RS07195	COG1518	maintenance of DNA repeat elements
IBB96_RS07200	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
IBB96_RS07210	COG0560	Phosphoserine phosphatase
IBB96_RS07220	COG0187	DNA topoisomerase II activity
IBB96_RS07230	COG1346	cytolysis
IBB96_RS07235	COG1380	Effector of murein hydrolase LrgA
IBB96_RS07245	COG1393	Belongs to the ArsC family
IBB96_RS07255	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IBB96_RS07290	COG1177	transmembrane transport
IBB96_RS07295	COG1176	ABC-type spermidine putrescine transport system, permease component I
IBB96_RS07335	COG0531	amino acid
IBB96_RS07340	COG0285	dihydrofolate synthase activity
IBB96_RS07345	COG1837	Belongs to the UPF0109 family
IBB96_RS07365	COG0708	Exodeoxyribonuclease III
IBB96_RS07380	COG1597	lipid kinase activity
IBB96_RS07390	COG4708	membrane
IBB96_RS07400	COG0024	Methionine aminopeptidase
IBB96_RS07405	COG4109	DRTGG domain
IBB96_RS07415	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IBB96_RS07420	COG2333	competence protein COMEC
IBB96_RS07420	COG0658	competence protein
IBB96_RS07425	COG1596	polysaccharide export
IBB96_RS07425	COG1555	photosystem II stabilization
IBB96_RS07430	COG0204	Acyl-transferase
IBB96_RS07440	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IBB96_RS07450	COG0513	Belongs to the DEAD box helicase family
IBB96_RS07470	COG1396	sequence-specific DNA binding
IBB96_RS07475	COG2211	Major facilitator Superfamily
IBB96_RS07490	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IBB96_RS07505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBB96_RS07510	COG1126	abc transporter atp-binding protein
IBB96_RS07515	COG0765	amino acid transport
IBB96_RS07520	COG0765	amino acid transport
IBB96_RS07535	COG2217	Heavy metal translocating P-type atpase
IBB96_RS07545	COG0159	tryptophan synthase activity
IBB96_RS07555	COG0135	phosphoribosylanthranilate isomerase activity
IBB96_RS07570	COG0512	Glutamine amidotransferase of anthranilate synthase
IBB96_RS07575	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IBB96_RS07580	COG1605	Chorismate mutase
IBB96_RS07580	COG0287	Prephenate dehydrogenase
IBB96_RS07590	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IBB96_RS07615	COG2176	DNA-directed DNA polymerase activity
IBB96_RS07625	COG2151	metal-sulfur cluster biosynthetic enzyme
IBB96_RS07635	COG2081	HI0933 family
IBB96_RS07660	COG1131	(ABC) transporter
IBB96_RS07665	COG0537	adenosine 5'-monophosphoramidase activity
IBB96_RS07685	COG3328	transposase activity
IBB96_RS07700	COG2226	methyltransferase
IBB96_RS07705	COG0799	negative regulation of ribosome biogenesis
IBB96_RS07710	COG1713	HD superfamily hydrolase involved in NAD metabolism
IBB96_RS07715	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IBB96_RS07720	COG1534	Rna-binding protein
IBB96_RS07725	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IBB96_RS07730	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
IBB96_RS07785	COG1335	isochorismatase
IBB96_RS07795	COG0436	Aminotransferase
IBB96_RS07800	COG0589	response to stress
IBB96_RS07820	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IBB96_RS07830	COG1253	flavin adenine dinucleotide binding
IBB96_RS07835	COG1119	ATPase activity
IBB96_RS07840	COG0025	NhaP-type Na H and K H
IBB96_RS07850	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
IBB96_RS07855	COG1242	4 iron, 4 sulfur cluster binding
IBB96_RS07860	COG3480	Lon protease (S16) C-terminal proteolytic domain
IBB96_RS07865	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IBB96_RS07870	COG0742	ribosomal rna small subunit methyltransferase
IBB96_RS07875	COG0492	ferredoxin-NADP+ reductase activity
IBB96_RS07885	COG1126	abc transporter atp-binding protein
IBB96_RS07895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBB96_RS07910	COG1882	Formate acetyltransferase
IBB96_RS07935	COG0390	transport system, permease component
IBB96_RS07940	COG4619	ABC transporter
IBB96_RS07945	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IBB96_RS07960	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IBB96_RS08025	COG3290	protein histidine kinase activity
IBB96_RS08035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IBB96_RS08040	COG2274	protein secretion by the type I secretion system
IBB96_RS08045	COG2274	protein secretion by the type I secretion system
IBB96_RS08050	COG1132	(ABC) transporter
IBB96_RS08055	COG1132	(ABC) transporter
IBB96_RS08070	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IBB96_RS08075	COG4470	Protein conserved in bacteria
IBB96_RS08080	COG0737	Belongs to the 5'-nucleotidase family
IBB96_RS08090	COG0513	Belongs to the DEAD box helicase family
IBB96_RS08100	COG0768	penicillin binding
IBB96_RS08130	COG3152	Membrane
IBB96_RS08140	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IBB96_RS08155	COG4152	abc transporter atp-binding protein
IBB96_RS08160	COG1811	Na channel or pump
IBB96_RS08200	COG0561	phosphatase activity
IBB96_RS08205	COG0252	asparaginase activity
IBB96_RS08210	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IBB96_RS08225	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IBB96_RS08230	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IBB96_RS08245	COG1482	cell wall glycoprotein biosynthetic process
IBB96_RS08250	COG1940	carbohydrate kinase activity
IBB96_RS08255	COG2190	(PTS) system
IBB96_RS08255	COG1263	PTS System
IBB96_RS08255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IBB96_RS08260	COG1621	beta-fructofuranosidase activity
IBB96_RS08265	COG1609	Transcriptional regulator
IBB96_RS08285	COG2131	deaminase
IBB96_RS08290	COG0006	proline dipeptidase activity
IBB96_RS08305	COG1131	(ABC) transporter
IBB96_RS08385	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IBB96_RS08385	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IBB96_RS08410	COG0681	Belongs to the peptidase S26 family
IBB96_RS08415	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IBB96_RS08425	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IBB96_RS08435	COG0456	acetyltransferase
IBB96_RS08440	COG1214	PFAM Peptidase M22, glycoprotease
IBB96_RS08460	COG0174	glutamine synthetase
IBB96_RS08465	COG0789	Transcriptional regulator
IBB96_RS08520	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IBB96_RS08565	COG0084	hydrolase, TatD family'
IBB96_RS08570	COG1832	CoA-binding protein
IBB96_RS08575	COG3118	belongs to the thioredoxin family
IBB96_RS08720	COG0756	dUTP diphosphatase activity
IBB96_RS08750	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IBB96_RS08760	COG0705	Rhomboid family
IBB96_RS08760	COG0457	Tetratricopeptide repeat
IBB96_RS08765	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IBB96_RS08785	COG2226	methyltransferase
IBB96_RS08810	COG0425	Belongs to the sulfur carrier protein TusA family
IBB96_RS08815	COG2391	methyltransferase activity
IBB96_RS08820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IBB96_RS08825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IBB96_RS08835	COG1363	Peptidase, m42
IBB96_RS08840	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IBB96_RS08845	COG1266	CAAX protease self-immunity
IBB96_RS08900	COG1459	type II secretion system
IBB96_RS08905	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IBB96_RS08940	COG0440	acetolactate synthase activity
IBB96_RS08945	COG0028	Belongs to the TPP enzyme family
IBB96_RS08955	COG1461	Dihydroxyacetone kinase
IBB96_RS08965	COG0534	Mate efflux family protein
IBB96_RS08980	COG1012	belongs to the aldehyde dehydrogenase family
IBB96_RS08980	COG1454	alcohol dehydrogenase
IBB96_RS08985	COG1454	alcohol dehydrogenase
IBB96_RS08985	COG1012	belongs to the aldehyde dehydrogenase family
IBB96_RS08990	COG1012	belongs to the aldehyde dehydrogenase family
IBB96_RS08990	COG1454	alcohol dehydrogenase
IBB96_RS09000	COG1012	belongs to the aldehyde dehydrogenase family
IBB96_RS09000	COG1454	alcohol dehydrogenase
IBB96_RS09005	COG3590	peptidase
IBB96_RS09020	COG1609	Transcriptional regulator
IBB96_RS09025	COG2188	Transcriptional regulator
IBB96_RS09030	COG4475	Protein of unknown function (DUF436)
IBB96_RS09060	COG1301	dicarboxylic acid transport
IBB96_RS09195	COG0201	protein transport
IBB96_RS09355	COG1132	(ABC) transporter
IBB96_RS09380	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IBB96_RS09410	COG1328	CTP reductase activity
IBB96_RS09420	COG0602	queuosine metabolic process
IBB96_RS09430	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IBB96_RS09455	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IBB96_RS09465	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IBB96_RS09475	COG0827	DNA restriction-modification system
IBB96_RS09480	COG0827	DNA restriction-modification system
IBB96_RS09525	COG4974	Belongs to the 'phage' integrase family
IBB96_RS09535	COG1597	lipid kinase activity
IBB96_RS09550	COG2261	transglycosylase associated protein
IBB96_RS09570	COG3237	CsbD-like
IBB96_RS09600	COG1511	domain protein
IBB96_RS09600	COG1511	domain protein
IBB96_RS09610	COG3759	membrane
IBB96_RS09705	COG0305	Participates in initiation and elongation during chromosome replication
IBB96_RS09725	COG0494	nUDIX hydrolase
IBB96_RS09740	COG0741	lytic transglycosylase activity
IBB96_RS09745	COG1388	LysM domain
IBB96_RS09745	COG3584	3D domain protein
IBB96_RS09750	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IBB96_RS09765	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IBB96_RS09775	COG0612	Peptidase, M16
IBB96_RS09805	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IBB96_RS09810	COG0488	(ABC) transporter
IBB96_RS09845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IBB96_RS09850	COG1475	DNA binding