locus-tag	class	description
IBB97_RS00010	COG0592	DNA-directed DNA polymerase activity
IBB97_RS00020	COG0012	GTP binding
IBB97_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IBB97_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IBB97_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IBB97_RS00195	COG3942	CHAP domain
IBB97_RS00210	COG0436	Aminotransferase
IBB97_RS00225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IBB97_RS00235	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IBB97_RS00250	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IBB97_RS00265	COG1388	LysM domain
IBB97_RS00265	COG3942	CHAP domain
IBB97_RS00270	COG0151	Belongs to the GarS family
IBB97_RS00275	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IBB97_RS00295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IBB97_RS00360	COG4550	Control of competence regulator ComK, YlbF/YmcA
IBB97_RS00400	COG2818	Glycosylase
IBB97_RS00415	COG1393	Belongs to the ArsC family
IBB97_RS00505	COG2309	aminopeptidase activity
IBB97_RS00520	COG0431	NADPH-dependent FMN reductase
IBB97_RS00560	COG4463	regulation of RNA biosynthetic process
IBB97_RS00565	COG0542	response to heat
IBB97_RS00575	COG1686	Belongs to the peptidase S11 family
IBB97_RS00590	COG1045	serine acetyltransferase
IBB97_RS00600	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
IBB97_RS00615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IBB97_RS00640	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IBB97_RS00700	COG1705	Flagellar rod assembly protein muramidase FlgJ
IBB97_RS00700	COG3942	CHAP domain
IBB97_RS00715	COG3830	Belongs to the UPF0237 family
IBB97_RS00730	COG1876	peptidase activity
IBB97_RS00765	COG0351	phosphomethylpyrimidine kinase
IBB97_RS00875	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IBB97_RS00895	COG0668	transmembrane transport
IBB97_RS00910	COG0504	CTP synthase activity
IBB97_RS00920	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IBB97_RS00930	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IBB97_RS00935	COG0737	Belongs to the 5'-nucleotidase family
IBB97_RS00985	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IBB97_RS01020	COG1126	abc transporter atp-binding protein
IBB97_RS01025	COG0765	amino acid transport
IBB97_RS01030	COG1968	undecaprenyl-diphosphatase activity
IBB97_RS01040	COG4862	establishment of competence for transformation
IBB97_RS01045	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IBB97_RS01055	COG0719	Fe-S assembly protein
IBB97_RS01060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IBB97_RS01070	COG0719	Fe-S assembly protein
IBB97_RS01110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IBB97_RS01135	COG1121	(ABC) transporter
IBB97_RS01140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IBB97_RS01180	COG4589	Belongs to the CDS family
IBB97_RS01195	COG4120	Belongs to the binding-protein-dependent transport system permease family
IBB97_RS01200	COG1116	anion transmembrane transporter activity
IBB97_RS01200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IBB97_RS01235	COG0564	pseudouridine synthase activity
IBB97_RS01240	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IBB97_RS01290	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IBB97_RS01305	COG3579	cysteine-type endopeptidase activity
IBB97_RS01315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IBB97_RS01340	COG0116	Belongs to the methyltransferase superfamily
IBB97_RS01350	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IBB97_RS01370	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IBB97_RS01395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IBB97_RS01440	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IBB97_RS01460	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IBB97_RS01465	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IBB97_RS01470	COG1187	pseudouridine synthase activity
IBB97_RS01480	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IBB97_RS01485	COG0569	domain protein
IBB97_RS01495	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
IBB97_RS01500	COG0671	phosphoesterase, PA-phosphatase related
IBB97_RS01520	COG2274	protein secretion by the type I secretion system
IBB97_RS01530	COG2274	protein secretion by the type I secretion system
IBB97_RS01585	COG0829	nickel cation binding
IBB97_RS01590	COG0310	cobalt ion transport
IBB97_RS01600	COG1122	ATPase activity
IBB97_RS01605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBB97_RS01610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IBB97_RS01630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBB97_RS01640	COG1464	Belongs to the NlpA lipoprotein family
IBB97_RS01665	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IBB97_RS01675	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
IBB97_RS01690	COG1122	ATPase activity
IBB97_RS01700	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IBB97_RS01710	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IBB97_RS01725	COG0745	RESPONSE REGULATOR receiver
IBB97_RS01730	COG5002	protein histidine kinase activity
IBB97_RS01745	COG1484	DNA-dependent DNA replication
IBB97_RS01790	COG3716	PTS system mannose fructose sorbose family IID component
IBB97_RS01795	COG3715	PTS system
IBB97_RS01805	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IBB97_RS01810	COG0561	phosphatase activity
IBB97_RS01815	COG2252	PERMEase
IBB97_RS01820	COG0802	atpase or kinase
IBB97_RS01825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IBB97_RS01830	COG1316	TRANSCRIPTIONal
IBB97_RS01840	COG0195	Participates in both transcription termination and antitermination
IBB97_RS01845	COG2740	Nucleic-acid-binding protein implicated in transcription termination
IBB97_RS01880	COG2244	polysaccharide biosynthetic process
IBB97_RS01885	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IBB97_RS01890	COG0626	cystathionine gamma-synthase activity
IBB97_RS01895	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IBB97_RS01925	COG4471	UPF0298 protein
IBB97_RS01935	COG0559	Belongs to the binding-protein-dependent transport system permease family
IBB97_RS01965	COG1739	Uncharacterized protein family UPF0029
IBB97_RS01970	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
IBB97_RS01975	COG1040	competence protein
IBB97_RS02065	COG0527	aspartate kinase activity
IBB97_RS02070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IBB97_RS02075	COG1024	Enoyl-CoA hydratase
IBB97_RS02080	COG1846	Transcriptional regulator
IBB97_RS02100	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IBB97_RS02105	COG1028	Short-chain dehydrogenase reductase Sdr
IBB97_RS02110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IBB97_RS02125	COG0439	Biotin carboxylase
IBB97_RS02155	COG0076	glutamate decarboxylase activity
IBB97_RS02160	COG0531	amino acid
IBB97_RS02240	COG1349	DNA-binding transcription factor activity
IBB97_RS02245	COG1105	Belongs to the carbohydrate kinase PfkB family
IBB97_RS02255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IBB97_RS02260	COG0285	dihydrofolate synthase activity
IBB97_RS02270	COG1104	cysteine desulfurase activity
IBB97_RS02330	COG0488	(ABC) transporter
IBB97_RS02350	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IBB97_RS02355	COG0242	peptide deformylase activity
IBB97_RS02415	COG1702	phosphate starvation-inducible protein PhoH
IBB97_RS02445	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IBB97_RS02445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IBB97_RS02465	COG4122	O-methyltransferase activity
IBB97_RS02470	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IBB97_RS02505	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IBB97_RS02510	COG0436	Aminotransferase
IBB97_RS02525	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IBB97_RS02530	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IBB97_RS02535	COG0726	polysaccharide deacetylase
IBB97_RS02550	COG2962	Rard protein
IBB97_RS02585	COG0356	it plays a direct role in the translocation of protons across the membrane
IBB97_RS02620	COG0772	Belongs to the SEDS family
IBB97_RS02640	COG0470	DNA polymerase III
IBB97_RS02645	COG1774	PSP1 C-terminal conserved region
IBB97_RS02650	COG4467	Involved in initiation control of chromosome replication
IBB97_RS02660	COG0004	ammonium transporteR
IBB97_RS02665	COG0347	Belongs to the P(II) protein family
IBB97_RS02670	COG1388	LysM domain
IBB97_RS02670	COG1705	Flagellar rod assembly protein muramidase FlgJ
IBB97_RS02715	COG1113	amino acid transport
IBB97_RS02755	COG0583	DNA-binding transcription factor activity
IBB97_RS02765	COG0564	pseudouridine synthase activity
IBB97_RS02785	COG0505	Belongs to the CarA family
IBB97_RS02845	COG0577	efflux transmembrane transporter activity
IBB97_RS02885	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IBB97_RS02900	COG3279	Response regulator of the LytR AlgR family
IBB97_RS02910	COG1131	(ABC) transporter
IBB97_RS02945	COG1187	pseudouridine synthase activity
IBB97_RS02950	COG1473	amidohydrolase
IBB97_RS02955	COG0686	Belongs to the AlaDH PNT family
IBB97_RS02960	COG0686	Belongs to the AlaDH PNT family
IBB97_RS02965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IBB97_RS03035	COG0438	transferase activity, transferring glycosyl groups
IBB97_RS03070	COG1272	protein, Hemolysin III
IBB97_RS03085	COG3425	synthase
IBB97_RS03095	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IBB97_RS03115	COG0833	amino acid
IBB97_RS03120	COG2040	homocysteine
IBB97_RS03140	COG0187	DNA topoisomerase II activity
IBB97_RS03150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IBB97_RS03170	COG0539	negative regulation of cytoplasmic translation
IBB97_RS03210	COG0494	nUDIX hydrolase
IBB97_RS03215	COG0542	response to heat
IBB97_RS03220	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IBB97_RS03225	COG4703	Protein of unknown function (DUF1797)
IBB97_RS03230	COG0765	amino acid transport
IBB97_RS03285	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IBB97_RS03290	COG0768	penicillin binding
IBB97_RS03295	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IBB97_RS03310	COG3711	transcriptional antiterminator
IBB97_RS03320	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IBB97_RS03325	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IBB97_RS03330	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IBB97_RS03335	COG0237	dephospho-CoA kinase activity
IBB97_RS03340	COG2814	Major facilitator Superfamily
IBB97_RS03355	COG0557	exoribonuclease II activity
IBB97_RS03370	COG1185	polyribonucleotide nucleotidyltransferase activity
IBB97_RS03375	COG0006	proline dipeptidase activity
IBB97_RS03380	COG1609	Transcriptional regulator
IBB97_RS03415	COG1368	sulfuric ester hydrolase activity
IBB97_RS03420	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IBB97_RS03445	COG0287	Prephenate dehydrogenase
IBB97_RS03470	COG0077	Prephenate dehydratase
IBB97_RS03530	COG1518	maintenance of DNA repeat elements
IBB97_RS03535	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IBB97_RS03545	COG3689	TIGRFAM TIGR03943 family protein
IBB97_RS03550	COG0701	Predicted permease
IBB97_RS03555	COG2183	response to ionizing radiation
IBB97_RS03605	COG0826	peptidase U32
IBB97_RS03615	COG1268	BioY protein
IBB97_RS03625	COG4443	Transcriptional Coactivator p15 (PC4)
IBB97_RS03630	COG1914	H( )-stimulated, divalent metal cation uptake system
IBB97_RS03660	COG3328	transposase activity
IBB97_RS03705	COG0406	alpha-ribazole phosphatase activity
IBB97_RS03710	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IBB97_RS03745	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IBB97_RS03755	COG0732	type I restriction modification DNA specificity domain
IBB97_RS03770	COG1704	LemA family
IBB97_RS03775	COG0501	Belongs to the peptidase M48B family
IBB97_RS03800	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IBB97_RS03815	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IBB97_RS03820	COG0783	Belongs to the Dps family
IBB97_RS03825	COG0735	belongs to the Fur family
IBB97_RS03830	COG4483	Protein conserved in bacteria
IBB97_RS03835	COG1940	carbohydrate kinase activity
IBB97_RS03840	COG1217	gtp-binding protein TYPA
IBB97_RS03875	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IBB97_RS03900	COG3599	regulation of cell shape
IBB97_RS03930	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IBB97_RS03935	COG0625	glutathione transferase activity
IBB97_RS03940	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IBB97_RS03955	COG2890	protein-(glutamine-N5) methyltransferase activity
IBB97_RS03985	COG1132	(ABC) transporter
IBB97_RS04000	COG1696	Membrane protein involved in D-alanine export
IBB97_RS04010	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
IBB97_RS04025	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IBB97_RS04030	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IBB97_RS04095	COG1396	sequence-specific DNA binding
IBB97_RS04100	COG0582	viral genome integration into host DNA
IBB97_RS04120	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IBB97_RS04125	COG4684	Psort location CytoplasmicMembrane, score
IBB97_RS04130	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IBB97_RS04155	COG5002	protein histidine kinase activity
IBB97_RS04180	COG2813	Specifically methylates the guanine in position
IBB97_RS04195	COG0295	cytidine deaminase activity
IBB97_RS04200	COG1744	ABC transporter substrate-binding protein PnrA-like
IBB97_RS04205	COG3845	ABC transporter
IBB97_RS04210	COG4603	Belongs to the binding-protein-dependent transport system permease family
IBB97_RS04215	COG1079	Belongs to the binding-protein-dependent transport system permease family
IBB97_RS04225	COG1199	ATP-dependent helicase activity
IBB97_RS04225	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IBB97_RS04235	COG0436	Aminotransferase
IBB97_RS04240	COG0017	Asparaginyl-tRNA synthetase
IBB97_RS04255	COG0251	oxidation-reduction process
IBB97_RS04265	COG0720	synthase
IBB97_RS04320	COG1278	Cold shock
IBB97_RS04335	COG2217	Heavy metal translocating P-type atpase
IBB97_RS04350	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IBB97_RS04355	COG0626	cystathionine gamma-synthase activity
IBB97_RS04360	COG1045	serine acetyltransferase
IBB97_RS04375	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IBB97_RS04390	COG4975	Glucose uptake
IBB97_RS04410	COG3443	Belongs to the bacterial solute-binding protein 9 family
IBB97_RS04410	COG0803	Belongs to the bacterial solute-binding protein 9 family
IBB97_RS04440	COG3942	CHAP domain
IBB97_RS04440	COG1705	Flagellar rod assembly protein muramidase FlgJ
IBB97_RS04455	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IBB97_RS04460	COG2824	Alkylphosphonate utilization operon protein PhnA
IBB97_RS04465	COG0765	amino acid transport
IBB97_RS04470	COG1126	abc transporter atp-binding protein
IBB97_RS04475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBB97_RS04485	COG1064	alcohol dehydrogenase
IBB97_RS04490	COG1064	alcohol dehydrogenase
IBB97_RS04500	COG3421	Type III restriction
IBB97_RS04505	COG2189	Belongs to the N(4) N(6)-methyltransferase family
IBB97_RS04510	COG0519	Catalyzes the synthesis of GMP from XMP
IBB97_RS04510	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IBB97_RS04515	COG2188	Transcriptional regulator
IBB97_RS04525	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IBB97_RS04535	COG1827	regulation of RNA biosynthetic process
IBB97_RS04545	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IBB97_RS04555	COG1940	carbohydrate kinase activity
IBB97_RS04560	COG0758	DNA mediated transformation
IBB97_RS04565	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IBB97_RS04585	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
IBB97_RS04615	COG0481	GTPase activity
IBB97_RS04620	COG1396	sequence-specific DNA binding
IBB97_RS04640	COG0010	Belongs to the arginase family
IBB97_RS04650	COG0028	Belongs to the TPP enzyme family
IBB97_RS04655	COG3527	Alpha-acetolactate decarboxylase
IBB97_RS04680	COG1230	cation diffusion facilitator family transporter
IBB97_RS04690	COG1063	alcohol dehydrogenase
IBB97_RS04710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IBB97_RS04725	COG1293	RNA-binding protein homologous to eukaryotic snRNP
IBB97_RS04755	COG0047	phosphoribosylformylglycinamidine synthase activity
IBB97_RS04770	COG0167	dihydroorotate dehydrogenase activity
IBB97_RS04780	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IBB97_RS04800	COG1337	RAMP superfamily
IBB97_RS04805	COG1567	CRISPR-associated RAMP protein, Csm4 family
IBB97_RS04820	COG0284	orotidine-5'-phosphate decarboxylase activity
IBB97_RS04835	COG3104	oligopeptide transport
IBB97_RS04840	COG0154	amidase activity
IBB97_RS04845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBB97_RS04850	COG0765	amino acid transport
IBB97_RS04875	COG1115	amino acid carrier protein
IBB97_RS04885	COG2873	o-acetylhomoserine
IBB97_RS04920	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IBB97_RS04925	COG0196	riboflavin kinase activity
IBB97_RS04930	COG1393	Belongs to the ArsC family
IBB97_RS04940	COG0483	inositol monophosphate 1-phosphatase activity
IBB97_RS04945	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
IBB97_RS04945	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IBB97_RS04955	COG0573	inorganic phosphate transmembrane transporter activity
IBB97_RS04960	COG0581	inorganic phosphate transmembrane transporter activity
IBB97_RS04975	COG0704	Plays a role in the regulation of phosphate uptake
IBB97_RS04990	COG0095	Lipoate-protein ligase
IBB97_RS05005	COG0058	SHG alpha-glucan phosphorylase activity
IBB97_RS05010	COG1640	4-alpha-glucanotransferase
IBB97_RS05020	COG1609	Transcriptional regulator
IBB97_RS05050	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IBB97_RS05055	COG0805	protein transport
IBB97_RS05060	COG0672	)-iron permease
IBB97_RS05065	COG2837	iron assimilation
IBB97_RS05070	COG2822	iron ion transport
IBB97_RS05075	COG4607	ABC-type enterochelin transport system periplasmic component
IBB97_RS05080	COG4604	ABC transporter, ATP-binding protein
IBB97_RS05085	COG4605	iron ion homeostasis
IBB97_RS05090	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IBB97_RS05110	COG0508	dehydrogenase complex catalyzes the overall conversion of
IBB97_RS05115	COG0508	dehydrogenase complex catalyzes the overall conversion of
IBB97_RS05115	COG0022	dehydrogenase e1 component
IBB97_RS05120	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IBB97_RS05140	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IBB97_RS05145	COG4667	esterase of the alpha-beta hydrolase superfamily
IBB97_RS05185	COG0628	permease
IBB97_RS05195	COG0561	phosphatase activity
IBB97_RS05220	COG2244	polysaccharide biosynthetic process
IBB97_RS05230	COG1216	Glycosyl transferase, family 2
IBB97_RS05230	COG1442	glycosyl transferase family 8
IBB97_RS05235	COG1442	glycosyl transferase family 8
IBB97_RS05245	COG1216	Glycosyl transferase, family 2
IBB97_RS05255	COG0438	transferase activity, transferring glycosyl groups
IBB97_RS05265	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IBB97_RS05290	COG1316	TRANSCRIPTIONal
IBB97_RS05325	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IBB97_RS05345	COG1573	uracil-dna glycosylase
IBB97_RS05410	COG0681	Belongs to the peptidase S26 family
IBB97_RS05420	COG0628	permease
IBB97_RS05425	COG1051	belongs to the nudix hydrolase family
IBB97_RS05430	COG2177	Part of the ABC transporter FtsEX involved in
IBB97_RS05435	COG2884	Cell division ATP-binding protein ftsE
IBB97_RS05445	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IBB97_RS05485	COG2348	transferase activity, transferring amino-acyl groups
IBB97_RS05495	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IBB97_RS05500	COG5002	protein histidine kinase activity
IBB97_RS05505	COG0745	RESPONSE REGULATOR receiver
IBB97_RS05510	COG1126	abc transporter atp-binding protein
IBB97_RS05515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBB97_RS05520	COG0765	amino acid transport
IBB97_RS05525	COG0765	amino acid transport
IBB97_RS05550	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IBB97_RS05560	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IBB97_RS05565	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IBB97_RS05565	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IBB97_RS05575	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IBB97_RS05580	COG1956	GAF domain-containing protein
IBB97_RS05585	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IBB97_RS05600	COG0335	large ribosomal subunit rRNA binding
IBB97_RS05605	COG0038	chloride channel
IBB97_RS05615	COG0038	chloride channel
IBB97_RS05620	COG0716	FMN binding
IBB97_RS05680	COG3328	transposase activity
IBB97_RS05750	COG3953	SLT domain
IBB97_RS05750	COG5412	phage tail tape measure protein
IBB97_RS05885	COG3935	DnaD domain protein
IBB97_RS05930	COG0469	pyruvate kinase activity
IBB97_RS05980	COG0167	dihydroorotate dehydrogenase activity
IBB97_RS05990	COG0776	regulation of translation
IBB97_RS06000	COG2755	lipolytic protein G-D-S-L family
IBB97_RS06005	COG1307	EDD domain protein, DegV family
IBB97_RS06010	COG0497	DNA recombination
IBB97_RS06015	COG1438	arginine binding
IBB97_RS06020	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
IBB97_RS06045	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IBB97_RS06065	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IBB97_RS06065	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IBB97_RS06070	COG0300	oxidoreductase activity
IBB97_RS06085	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IBB97_RS06090	COG0772	Belongs to the SEDS family
IBB97_RS06105	COG0107	imidazoleglycerol-phosphate synthase activity
IBB97_RS06115	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IBB97_RS06125	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IBB97_RS06170	COG0647	UMP catabolic process
IBB97_RS06180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IBB97_RS06205	COG1088	dTDP-glucose 4,6-dehydratase activity
IBB97_RS06215	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IBB97_RS06220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IBB97_RS06235	COG2384	SAM-dependent methyltransferase
IBB97_RS06260	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IBB97_RS06265	COG3442	glutamine amidotransferase
IBB97_RS06270	COG0392	lysyltransferase activity
IBB97_RS06270	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IBB97_RS06280	COG0488	(ABC) transporter
IBB97_RS06290	COG0513	Belongs to the DEAD box helicase family
IBB97_RS06325	COG0372	Belongs to the citrate synthase family
IBB97_RS06330	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IBB97_RS06335	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IBB97_RS06340	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IBB97_RS06345	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IBB97_RS06380	COG3764	Sortase (surface protein transpeptidase)
IBB97_RS06400	COG0488	(ABC) transporter
IBB97_RS06425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IBB97_RS06430	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IBB97_RS06430	COG1328	CTP reductase activity
IBB97_RS06455	COG1196	nuclear chromosome segregation
IBB97_RS06470	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IBB97_RS06485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IBB97_RS06495	COG1011	Hydrolase
IBB97_RS06505	COG1760	l-serine dehydratase
IBB97_RS06510	COG1760	l-serine dehydratase
IBB97_RS06535	COG2197	response regulator
IBB97_RS06540	COG4585	Histidine kinase
IBB97_RS06550	COG1131	(ABC) transporter
IBB97_RS06565	COG0385	Bile acid
IBB97_RS06580	COG1131	(ABC) transporter
IBB97_RS06600	COG0577	efflux transmembrane transporter activity
IBB97_RS06605	COG1136	(ABC) transporter
IBB97_RS06610	COG0784	Response regulator, receiver
IBB97_RS06610	COG2198	Histidine kinase
IBB97_RS06610	COG5002	protein histidine kinase activity
IBB97_RS06615	COG0745	RESPONSE REGULATOR receiver
IBB97_RS06630	COG0534	Mate efflux family protein
IBB97_RS06635	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IBB97_RS06635	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IBB97_RS06650	COG1126	abc transporter atp-binding protein
IBB97_RS06655	COG0765	amino acid transport
IBB97_RS06665	COG2079	MmgE PrpD family protein
IBB97_RS06670	COG0436	Aminotransferase
IBB97_RS06705	COG0531	amino acid
IBB97_RS06725	COG1126	abc transporter atp-binding protein
IBB97_RS06730	COG0765	amino acid transport
IBB97_RS06735	COG0765	amino acid transport
IBB97_RS06740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBB97_RS06750	COG0386	Belongs to the glutathione peroxidase family
IBB97_RS06785	COG2514	catechol 2,3-dioxygenase activity
IBB97_RS06790	COG1959	2 iron, 2 sulfur cluster binding
IBB97_RS06800	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IBB97_RS06800	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IBB97_RS06805	COG0778	Nitroreductase
IBB97_RS06815	COG0656	L-ascorbic acid biosynthetic process
IBB97_RS06820	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IBB97_RS06855	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IBB97_RS06880	COG1280	lysine exporter protein (LysE YggA)
IBB97_RS06890	COG1442	glycosyl transferase family 8
IBB97_RS06890	COG1216	Glycosyl transferase, family 2
IBB97_RS06895	COG0577	efflux transmembrane transporter activity
IBB97_RS06950	COG1396	sequence-specific DNA binding
IBB97_RS06970	COG0419	ATPase involved in DNA repair
IBB97_RS06975	COG0420	3'-5' exonuclease activity
IBB97_RS06985	COG3250	beta-galactosidase activity
IBB97_RS06990	COG2190	(PTS) system
IBB97_RS06990	COG2211	Major facilitator Superfamily
IBB97_RS06995	COG2017	converts alpha-aldose to the beta-anomer
IBB97_RS07000	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IBB97_RS07015	COG1609	Transcriptional regulator
IBB97_RS07040	COG0488	(ABC) transporter
IBB97_RS07105	COG2197	response regulator
IBB97_RS07110	COG4585	Histidine kinase
IBB97_RS07125	COG0515	serine threonine protein kinase
IBB97_RS07125	COG2815	serine threonine protein kinase
IBB97_RS07135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IBB97_RS07135	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IBB97_RS07145	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IBB97_RS07160	COG0552	protein localization to endoplasmic reticulum
IBB97_RS07165	COG0561	phosphatase activity
IBB97_RS07170	COG0561	phosphatase activity
IBB97_RS07175	COG1725	Transcriptional regulator
IBB97_RS07180	COG1131	(ABC) transporter
IBB97_RS07190	COG4608	Belongs to the ABC transporter superfamily
IBB97_RS07195	COG0444	Belongs to the ABC transporter superfamily
IBB97_RS07200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IBB97_RS07205	COG0601	transmembrane transport
IBB97_RS07210	COG4166	transmembrane transport
IBB97_RS07220	COG4166	transmembrane transport
IBB97_RS07255	COG4608	Belongs to the ABC transporter superfamily
IBB97_RS07260	COG4608	Belongs to the ABC transporter superfamily
IBB97_RS07265	COG0084	hydrolase, TatD family'
IBB97_RS07270	COG2223	nitrite transmembrane transporter activity
IBB97_RS07280	COG0280	phosphate acetyltransferase
IBB97_RS07285	COG0564	pseudouridine synthase activity
IBB97_RS07295	COG2357	RelA SpoT domain protein
IBB97_RS07310	COG1104	cysteine desulfurase activity
IBB97_RS07330	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IBB97_RS07335	COG2003	Belongs to the UPF0758 family
IBB97_RS07360	COG1215	transferase activity, transferring glycosyl groups
IBB97_RS07370	COG1442	glycosyl transferase family 8
IBB97_RS07370	COG1216	Glycosyl transferase, family 2
IBB97_RS07390	COG1091	dTDP-4-dehydrorhamnose reductase activity
IBB97_RS07400	COG0463	Glycosyl transferase, family 2
IBB97_RS07410	COG2151	metal-sulfur cluster biosynthetic enzyme
IBB97_RS07415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IBB97_RS07420	COG0358	DNA primase activity
IBB97_RS07435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBB97_RS07440	COG0436	Aminotransferase
IBB97_RS07445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBB97_RS07450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBB97_RS07455	COG1051	belongs to the nudix hydrolase family
IBB97_RS07475	COG0765	amino acid transport
IBB97_RS07480	COG1126	abc transporter atp-binding protein
IBB97_RS07500	COG1187	pseudouridine synthase activity
IBB97_RS07545	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IBB97_RS07550	COG1518	maintenance of DNA repeat elements
IBB97_RS07555	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
IBB97_RS07560	COG0560	Phosphoserine phosphatase
IBB97_RS07570	COG0187	DNA topoisomerase II activity
IBB97_RS07580	COG1346	cytolysis
IBB97_RS07585	COG1380	Effector of murein hydrolase LrgA
IBB97_RS07595	COG1393	Belongs to the ArsC family
IBB97_RS07605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IBB97_RS07640	COG1177	transmembrane transport
IBB97_RS07645	COG1176	ABC-type spermidine putrescine transport system, permease component I
IBB97_RS07685	COG0531	amino acid
IBB97_RS07690	COG0285	dihydrofolate synthase activity
IBB97_RS07695	COG1837	Belongs to the UPF0109 family
IBB97_RS07705	COG0500	methyltransferase
IBB97_RS07705	COG3615	Tellurite resistance protein tehB
IBB97_RS07715	COG0708	Exodeoxyribonuclease III
IBB97_RS07730	COG1597	lipid kinase activity
IBB97_RS07740	COG4708	membrane
IBB97_RS07750	COG0024	Methionine aminopeptidase
IBB97_RS07755	COG4109	DRTGG domain
IBB97_RS07765	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IBB97_RS07770	COG2333	competence protein COMEC
IBB97_RS07770	COG0658	competence protein
IBB97_RS07775	COG1596	polysaccharide export
IBB97_RS07775	COG1555	photosystem II stabilization
IBB97_RS07780	COG0204	Acyl-transferase
IBB97_RS07790	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IBB97_RS07800	COG0513	Belongs to the DEAD box helicase family
IBB97_RS07820	COG1396	sequence-specific DNA binding
IBB97_RS07825	COG2211	Major facilitator Superfamily
IBB97_RS07840	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IBB97_RS07855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBB97_RS07860	COG1126	abc transporter atp-binding protein
IBB97_RS07865	COG0765	amino acid transport
IBB97_RS07870	COG0765	amino acid transport
IBB97_RS07885	COG2217	Heavy metal translocating P-type atpase
IBB97_RS07895	COG0159	tryptophan synthase activity
IBB97_RS07905	COG0135	phosphoribosylanthranilate isomerase activity
IBB97_RS07920	COG0512	Glutamine amidotransferase of anthranilate synthase
IBB97_RS07925	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IBB97_RS07930	COG1605	Chorismate mutase
IBB97_RS07930	COG0287	Prephenate dehydrogenase
IBB97_RS07940	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IBB97_RS07965	COG2176	DNA-directed DNA polymerase activity
IBB97_RS07975	COG2151	metal-sulfur cluster biosynthetic enzyme
IBB97_RS07985	COG2081	HI0933 family
IBB97_RS08010	COG1131	(ABC) transporter
IBB97_RS08015	COG0537	adenosine 5'-monophosphoramidase activity
IBB97_RS08035	COG3328	transposase activity
IBB97_RS08050	COG2226	methyltransferase
IBB97_RS08055	COG0799	negative regulation of ribosome biogenesis
IBB97_RS08060	COG1713	HD superfamily hydrolase involved in NAD metabolism
IBB97_RS08065	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IBB97_RS08070	COG1534	Rna-binding protein
IBB97_RS08075	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IBB97_RS08080	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
IBB97_RS08135	COG1335	isochorismatase
IBB97_RS08145	COG0436	Aminotransferase
IBB97_RS08150	COG0589	response to stress
IBB97_RS08170	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IBB97_RS08180	COG1253	flavin adenine dinucleotide binding
IBB97_RS08185	COG1119	ATPase activity
IBB97_RS08190	COG0025	NhaP-type Na H and K H
IBB97_RS08200	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
IBB97_RS08205	COG1242	4 iron, 4 sulfur cluster binding
IBB97_RS08210	COG3480	Lon protease (S16) C-terminal proteolytic domain
IBB97_RS08215	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IBB97_RS08220	COG0742	ribosomal rna small subunit methyltransferase
IBB97_RS08225	COG0492	ferredoxin-NADP+ reductase activity
IBB97_RS08235	COG1126	abc transporter atp-binding protein
IBB97_RS08245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBB97_RS08260	COG1882	Formate acetyltransferase
IBB97_RS08285	COG0390	transport system, permease component
IBB97_RS08290	COG4619	ABC transporter
IBB97_RS08295	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IBB97_RS08310	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IBB97_RS08385	COG3290	protein histidine kinase activity
IBB97_RS08395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IBB97_RS08400	COG2274	protein secretion by the type I secretion system
IBB97_RS08405	COG2274	protein secretion by the type I secretion system
IBB97_RS08410	COG1132	(ABC) transporter
IBB97_RS08415	COG1132	(ABC) transporter
IBB97_RS08430	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IBB97_RS08435	COG4470	Protein conserved in bacteria
IBB97_RS08440	COG0737	Belongs to the 5'-nucleotidase family
IBB97_RS08450	COG0513	Belongs to the DEAD box helicase family
IBB97_RS08460	COG0768	penicillin binding
IBB97_RS08490	COG3152	Membrane
IBB97_RS08500	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IBB97_RS08515	COG4152	abc transporter atp-binding protein
IBB97_RS08520	COG1811	Na channel or pump
IBB97_RS08560	COG0561	phosphatase activity
IBB97_RS08565	COG0252	asparaginase activity
IBB97_RS08570	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IBB97_RS08585	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IBB97_RS08590	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IBB97_RS08605	COG1482	cell wall glycoprotein biosynthetic process
IBB97_RS08610	COG1940	carbohydrate kinase activity
IBB97_RS08615	COG1263	PTS System
IBB97_RS08615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IBB97_RS08615	COG2190	(PTS) system
IBB97_RS08620	COG1621	beta-fructofuranosidase activity
IBB97_RS08625	COG1609	Transcriptional regulator
IBB97_RS08645	COG2131	deaminase
IBB97_RS08650	COG0006	proline dipeptidase activity
IBB97_RS08665	COG1131	(ABC) transporter
IBB97_RS08745	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IBB97_RS08745	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IBB97_RS08770	COG0681	Belongs to the peptidase S26 family
IBB97_RS08775	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IBB97_RS08785	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IBB97_RS08795	COG0456	acetyltransferase
IBB97_RS08800	COG1214	PFAM Peptidase M22, glycoprotease
IBB97_RS08820	COG0174	glutamine synthetase
IBB97_RS08825	COG0789	Transcriptional regulator
IBB97_RS08880	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IBB97_RS08925	COG0084	hydrolase, TatD family'
IBB97_RS08930	COG1832	CoA-binding protein
IBB97_RS08935	COG3118	belongs to the thioredoxin family
IBB97_RS09005	COG0706	membrane insertase activity
IBB97_RS09065	COG0756	dUTP diphosphatase activity
IBB97_RS09075	COG0431	NADPH-dependent FMN reductase
IBB97_RS09075	COG1053	succinate dehydrogenase
IBB97_RS09075	COG3976	FMN-binding domain protein
IBB97_RS09100	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IBB97_RS09110	COG0705	Rhomboid family
IBB97_RS09110	COG0457	Tetratricopeptide repeat
IBB97_RS09115	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IBB97_RS09135	COG2226	methyltransferase
IBB97_RS09160	COG0425	Belongs to the sulfur carrier protein TusA family
IBB97_RS09165	COG2391	methyltransferase activity
IBB97_RS09170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IBB97_RS09175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IBB97_RS09185	COG1363	Peptidase, m42
IBB97_RS09190	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IBB97_RS09195	COG1266	CAAX protease self-immunity
IBB97_RS09255	COG1459	type II secretion system
IBB97_RS09260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IBB97_RS09295	COG0440	acetolactate synthase activity
IBB97_RS09300	COG0028	Belongs to the TPP enzyme family
IBB97_RS09310	COG1461	Dihydroxyacetone kinase
IBB97_RS09320	COG0534	Mate efflux family protein
IBB97_RS09335	COG1012	belongs to the aldehyde dehydrogenase family
IBB97_RS09335	COG1454	alcohol dehydrogenase
IBB97_RS09340	COG1454	alcohol dehydrogenase
IBB97_RS09340	COG1012	belongs to the aldehyde dehydrogenase family
IBB97_RS09345	COG1012	belongs to the aldehyde dehydrogenase family
IBB97_RS09345	COG1454	alcohol dehydrogenase
IBB97_RS09355	COG1012	belongs to the aldehyde dehydrogenase family
IBB97_RS09355	COG1454	alcohol dehydrogenase
IBB97_RS09360	COG3590	peptidase
IBB97_RS09375	COG1609	Transcriptional regulator
IBB97_RS09380	COG2188	Transcriptional regulator
IBB97_RS09385	COG4475	Protein of unknown function (DUF436)
IBB97_RS09415	COG1301	dicarboxylic acid transport
IBB97_RS09485	COG0191	fructose-bisphosphate aldolase activity
IBB97_RS09550	COG0201	protein transport
IBB97_RS09710	COG1132	(ABC) transporter
IBB97_RS09735	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IBB97_RS09765	COG1328	CTP reductase activity
IBB97_RS09775	COG0602	queuosine metabolic process
IBB97_RS09785	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IBB97_RS09810	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IBB97_RS09820	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IBB97_RS09830	COG1002	Type II restriction enzyme, methylase subunits
IBB97_RS09860	COG0582	viral genome integration into host DNA
IBB97_RS09875	COG1597	lipid kinase activity
IBB97_RS09890	COG2261	transglycosylase associated protein
IBB97_RS09910	COG3237	CsbD-like
IBB97_RS09940	COG1511	domain protein
IBB97_RS09940	COG1511	domain protein
IBB97_RS09950	COG3759	membrane
IBB97_RS09970	COG0305	Participates in initiation and elongation during chromosome replication
IBB97_RS09990	COG0494	nUDIX hydrolase
IBB97_RS10005	COG0741	lytic transglycosylase activity
IBB97_RS10010	COG1388	LysM domain
IBB97_RS10010	COG3584	3D domain protein
IBB97_RS10015	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IBB97_RS10030	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IBB97_RS10040	COG0612	Peptidase, M16
IBB97_RS10070	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IBB97_RS10075	COG0488	(ABC) transporter
IBB97_RS10110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IBB97_RS10115	COG1475	DNA binding