locus-tag	class	description
IBC04_RS00010	COG0592	DNA-directed DNA polymerase activity
IBC04_RS00020	COG0012	GTP binding
IBC04_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IBC04_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IBC04_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IBC04_RS00195	COG3942	CHAP domain
IBC04_RS00210	COG0436	Aminotransferase
IBC04_RS00225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IBC04_RS00235	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IBC04_RS00250	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IBC04_RS00265	COG1388	LysM domain
IBC04_RS00265	COG3942	CHAP domain
IBC04_RS00270	COG0151	Belongs to the GarS family
IBC04_RS00275	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IBC04_RS00295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IBC04_RS00360	COG4550	Control of competence regulator ComK, YlbF/YmcA
IBC04_RS00400	COG2818	Glycosylase
IBC04_RS00415	COG1393	Belongs to the ArsC family
IBC04_RS00505	COG2309	aminopeptidase activity
IBC04_RS00520	COG0431	NADPH-dependent FMN reductase
IBC04_RS00560	COG4463	regulation of RNA biosynthetic process
IBC04_RS00565	COG0542	response to heat
IBC04_RS00575	COG1686	Belongs to the peptidase S11 family
IBC04_RS00590	COG1045	serine acetyltransferase
IBC04_RS00600	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
IBC04_RS00615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IBC04_RS00640	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IBC04_RS00700	COG1705	Flagellar rod assembly protein muramidase FlgJ
IBC04_RS00700	COG3942	CHAP domain
IBC04_RS00715	COG3830	Belongs to the UPF0237 family
IBC04_RS00730	COG1876	peptidase activity
IBC04_RS00765	COG0351	phosphomethylpyrimidine kinase
IBC04_RS00810	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IBC04_RS00830	COG0668	transmembrane transport
IBC04_RS00845	COG0504	CTP synthase activity
IBC04_RS00855	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IBC04_RS00865	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IBC04_RS00870	COG0737	Belongs to the 5'-nucleotidase family
IBC04_RS00920	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IBC04_RS00955	COG1126	abc transporter atp-binding protein
IBC04_RS00960	COG0765	amino acid transport
IBC04_RS00965	COG1968	undecaprenyl-diphosphatase activity
IBC04_RS00975	COG4862	establishment of competence for transformation
IBC04_RS00980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IBC04_RS00990	COG0719	Fe-S assembly protein
IBC04_RS00995	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IBC04_RS01005	COG0719	Fe-S assembly protein
IBC04_RS01045	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IBC04_RS01070	COG1121	(ABC) transporter
IBC04_RS01075	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IBC04_RS01115	COG4589	Belongs to the CDS family
IBC04_RS01130	COG4120	Belongs to the binding-protein-dependent transport system permease family
IBC04_RS01135	COG1116	anion transmembrane transporter activity
IBC04_RS01135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IBC04_RS01170	COG0564	pseudouridine synthase activity
IBC04_RS01175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IBC04_RS01225	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IBC04_RS01240	COG3579	cysteine-type endopeptidase activity
IBC04_RS01250	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IBC04_RS01275	COG0116	Belongs to the methyltransferase superfamily
IBC04_RS01285	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IBC04_RS01305	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IBC04_RS01325	COG1254	Belongs to the acylphosphatase family
IBC04_RS01330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IBC04_RS01370	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IBC04_RS01390	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IBC04_RS01395	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IBC04_RS01400	COG1187	pseudouridine synthase activity
IBC04_RS01410	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IBC04_RS01415	COG0569	domain protein
IBC04_RS01425	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
IBC04_RS01430	COG0671	phosphoesterase, PA-phosphatase related
IBC04_RS01450	COG2274	protein secretion by the type I secretion system
IBC04_RS01460	COG2274	protein secretion by the type I secretion system
IBC04_RS01510	COG0829	nickel cation binding
IBC04_RS01515	COG0310	cobalt ion transport
IBC04_RS01525	COG1122	ATPase activity
IBC04_RS01530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBC04_RS01535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IBC04_RS01555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBC04_RS01560	COG1464	Belongs to the NlpA lipoprotein family
IBC04_RS01585	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IBC04_RS01595	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
IBC04_RS01610	COG1122	ATPase activity
IBC04_RS01620	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IBC04_RS01630	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IBC04_RS01645	COG0745	RESPONSE REGULATOR receiver
IBC04_RS01650	COG5002	protein histidine kinase activity
IBC04_RS01665	COG1484	DNA-dependent DNA replication
IBC04_RS01710	COG3716	PTS system mannose fructose sorbose family IID component
IBC04_RS01715	COG3715	PTS system
IBC04_RS01725	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IBC04_RS01730	COG0561	phosphatase activity
IBC04_RS01735	COG2252	PERMEase
IBC04_RS01740	COG0802	atpase or kinase
IBC04_RS01745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IBC04_RS01750	COG1316	TRANSCRIPTIONal
IBC04_RS01760	COG0195	Participates in both transcription termination and antitermination
IBC04_RS01765	COG2740	Nucleic-acid-binding protein implicated in transcription termination
IBC04_RS01800	COG2244	polysaccharide biosynthetic process
IBC04_RS01805	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IBC04_RS01810	COG0626	cystathionine gamma-synthase activity
IBC04_RS01815	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IBC04_RS01845	COG4471	UPF0298 protein
IBC04_RS01855	COG0559	Belongs to the binding-protein-dependent transport system permease family
IBC04_RS01885	COG1739	Uncharacterized protein family UPF0029
IBC04_RS01890	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
IBC04_RS01895	COG1040	competence protein
IBC04_RS01985	COG0527	aspartate kinase activity
IBC04_RS01990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IBC04_RS01995	COG1024	Enoyl-CoA hydratase
IBC04_RS02000	COG1846	Transcriptional regulator
IBC04_RS02020	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IBC04_RS02025	COG1028	Short-chain dehydrogenase reductase Sdr
IBC04_RS02030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IBC04_RS02045	COG0439	Biotin carboxylase
IBC04_RS02075	COG0076	glutamate decarboxylase activity
IBC04_RS02080	COG0531	amino acid
IBC04_RS02160	COG1349	DNA-binding transcription factor activity
IBC04_RS02165	COG1105	Belongs to the carbohydrate kinase PfkB family
IBC04_RS02175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IBC04_RS02180	COG0285	dihydrofolate synthase activity
IBC04_RS02190	COG1104	cysteine desulfurase activity
IBC04_RS02250	COG0488	(ABC) transporter
IBC04_RS02270	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IBC04_RS02275	COG0242	peptide deformylase activity
IBC04_RS02335	COG1702	phosphate starvation-inducible protein PhoH
IBC04_RS02365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IBC04_RS02365	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IBC04_RS02385	COG4122	O-methyltransferase activity
IBC04_RS02390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IBC04_RS02425	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IBC04_RS02430	COG0436	Aminotransferase
IBC04_RS02445	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IBC04_RS02450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IBC04_RS02455	COG0726	polysaccharide deacetylase
IBC04_RS02470	COG2962	Rard protein
IBC04_RS02505	COG0356	it plays a direct role in the translocation of protons across the membrane
IBC04_RS02540	COG0772	Belongs to the SEDS family
IBC04_RS02560	COG0470	DNA polymerase III
IBC04_RS02565	COG1774	PSP1 C-terminal conserved region
IBC04_RS02570	COG4467	Involved in initiation control of chromosome replication
IBC04_RS02580	COG0004	ammonium transporteR
IBC04_RS02585	COG0347	Belongs to the P(II) protein family
IBC04_RS02590	COG1388	LysM domain
IBC04_RS02590	COG1705	Flagellar rod assembly protein muramidase FlgJ
IBC04_RS02635	COG1113	amino acid transport
IBC04_RS02675	COG0583	DNA-binding transcription factor activity
IBC04_RS02685	COG0564	pseudouridine synthase activity
IBC04_RS02705	COG0505	Belongs to the CarA family
IBC04_RS02750	COG1132	(ABC) transporter
IBC04_RS02755	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IBC04_RS02770	COG3279	Response regulator of the LytR AlgR family
IBC04_RS02780	COG1131	(ABC) transporter
IBC04_RS02815	COG1187	pseudouridine synthase activity
IBC04_RS02820	COG1473	amidohydrolase
IBC04_RS02825	COG0686	Belongs to the AlaDH PNT family
IBC04_RS02830	COG0686	Belongs to the AlaDH PNT family
IBC04_RS02835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IBC04_RS02905	COG0438	transferase activity, transferring glycosyl groups
IBC04_RS02940	COG1272	protein, Hemolysin III
IBC04_RS02955	COG3425	synthase
IBC04_RS02965	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IBC04_RS02985	COG0833	amino acid
IBC04_RS02990	COG2040	homocysteine
IBC04_RS03010	COG0187	DNA topoisomerase II activity
IBC04_RS03020	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IBC04_RS03040	COG0539	negative regulation of cytoplasmic translation
IBC04_RS03080	COG0494	nUDIX hydrolase
IBC04_RS03085	COG0542	response to heat
IBC04_RS03090	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IBC04_RS03095	COG4703	Protein of unknown function (DUF1797)
IBC04_RS03100	COG0765	amino acid transport
IBC04_RS03155	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IBC04_RS03160	COG0768	penicillin binding
IBC04_RS03165	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IBC04_RS03180	COG3711	transcriptional antiterminator
IBC04_RS03190	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IBC04_RS03195	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IBC04_RS03200	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IBC04_RS03205	COG0237	dephospho-CoA kinase activity
IBC04_RS03210	COG2814	Major facilitator Superfamily
IBC04_RS03225	COG0557	exoribonuclease II activity
IBC04_RS03240	COG1185	polyribonucleotide nucleotidyltransferase activity
IBC04_RS03245	COG0006	proline dipeptidase activity
IBC04_RS03250	COG1609	Transcriptional regulator
IBC04_RS03285	COG1368	sulfuric ester hydrolase activity
IBC04_RS03290	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IBC04_RS03315	COG0287	Prephenate dehydrogenase
IBC04_RS03340	COG0077	Prephenate dehydratase
IBC04_RS03400	COG1518	maintenance of DNA repeat elements
IBC04_RS03405	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IBC04_RS03415	COG3689	TIGRFAM TIGR03943 family protein
IBC04_RS03420	COG0701	Predicted permease
IBC04_RS03425	COG2183	response to ionizing radiation
IBC04_RS03470	COG0826	peptidase U32
IBC04_RS03480	COG1268	BioY protein
IBC04_RS03490	COG4443	Transcriptional Coactivator p15 (PC4)
IBC04_RS03495	COG1914	H( )-stimulated, divalent metal cation uptake system
IBC04_RS03555	COG0406	alpha-ribazole phosphatase activity
IBC04_RS03560	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IBC04_RS03610	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IBC04_RS03620	COG0732	type I restriction modification DNA specificity domain
IBC04_RS03655	COG1704	LemA family
IBC04_RS03660	COG0501	Belongs to the peptidase M48B family
IBC04_RS03685	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IBC04_RS03700	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IBC04_RS03705	COG0783	Belongs to the Dps family
IBC04_RS03710	COG0735	belongs to the Fur family
IBC04_RS03715	COG4483	Protein conserved in bacteria
IBC04_RS03720	COG1940	carbohydrate kinase activity
IBC04_RS03725	COG1217	gtp-binding protein TYPA
IBC04_RS03760	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IBC04_RS03785	COG3599	regulation of cell shape
IBC04_RS03815	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IBC04_RS03820	COG0625	glutathione transferase activity
IBC04_RS03840	COG2890	protein-(glutamine-N5) methyltransferase activity
IBC04_RS03870	COG1132	(ABC) transporter
IBC04_RS03885	COG1696	Membrane protein involved in D-alanine export
IBC04_RS03895	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
IBC04_RS03910	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IBC04_RS03915	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IBC04_RS03935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IBC04_RS03940	COG4684	Psort location CytoplasmicMembrane, score
IBC04_RS03945	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IBC04_RS03970	COG5002	protein histidine kinase activity
IBC04_RS03995	COG2813	Specifically methylates the guanine in position
IBC04_RS04015	COG1744	ABC transporter substrate-binding protein PnrA-like
IBC04_RS04020	COG3845	ABC transporter
IBC04_RS04025	COG4603	Belongs to the binding-protein-dependent transport system permease family
IBC04_RS04030	COG1079	Belongs to the binding-protein-dependent transport system permease family
IBC04_RS04040	COG1199	ATP-dependent helicase activity
IBC04_RS04040	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IBC04_RS04050	COG0436	Aminotransferase
IBC04_RS04055	COG0017	Asparaginyl-tRNA synthetase
IBC04_RS04070	COG0251	oxidation-reduction process
IBC04_RS04080	COG0720	synthase
IBC04_RS04130	COG1278	Cold shock
IBC04_RS04145	COG2217	Heavy metal translocating P-type atpase
IBC04_RS04160	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IBC04_RS04165	COG0626	cystathionine gamma-synthase activity
IBC04_RS04170	COG1045	serine acetyltransferase
IBC04_RS04195	COG4975	Glucose uptake
IBC04_RS04220	COG3443	Belongs to the bacterial solute-binding protein 9 family
IBC04_RS04220	COG0803	Belongs to the bacterial solute-binding protein 9 family
IBC04_RS04245	COG3942	CHAP domain
IBC04_RS04245	COG1705	Flagellar rod assembly protein muramidase FlgJ
IBC04_RS04260	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IBC04_RS04265	COG2824	Alkylphosphonate utilization operon protein PhnA
IBC04_RS04270	COG0765	amino acid transport
IBC04_RS04275	COG1126	abc transporter atp-binding protein
IBC04_RS04280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBC04_RS04290	COG1064	alcohol dehydrogenase
IBC04_RS04295	COG1064	alcohol dehydrogenase
IBC04_RS04305	COG3421	Type III restriction
IBC04_RS04310	COG2189	Belongs to the N(4) N(6)-methyltransferase family
IBC04_RS04315	COG0519	Catalyzes the synthesis of GMP from XMP
IBC04_RS04315	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IBC04_RS04320	COG2188	Transcriptional regulator
IBC04_RS04330	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IBC04_RS04340	COG1827	regulation of RNA biosynthetic process
IBC04_RS04350	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IBC04_RS04360	COG1940	carbohydrate kinase activity
IBC04_RS04365	COG0758	DNA mediated transformation
IBC04_RS04370	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IBC04_RS04420	COG0481	GTPase activity
IBC04_RS04425	COG1396	sequence-specific DNA binding
IBC04_RS04445	COG0010	Belongs to the arginase family
IBC04_RS04455	COG0028	Belongs to the TPP enzyme family
IBC04_RS04460	COG3527	Alpha-acetolactate decarboxylase
IBC04_RS04485	COG1230	cation diffusion facilitator family transporter
IBC04_RS04495	COG1063	alcohol dehydrogenase
IBC04_RS04515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IBC04_RS04530	COG1293	RNA-binding protein homologous to eukaryotic snRNP
IBC04_RS04585	COG0047	phosphoribosylformylglycinamidine synthase activity
IBC04_RS04595	COG0167	dihydroorotate dehydrogenase activity
IBC04_RS04605	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IBC04_RS04625	COG1337	RAMP superfamily
IBC04_RS04630	COG1567	CRISPR-associated RAMP protein, Csm4 family
IBC04_RS04645	COG0284	orotidine-5'-phosphate decarboxylase activity
IBC04_RS04660	COG3104	oligopeptide transport
IBC04_RS04665	COG0154	amidase activity
IBC04_RS04670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBC04_RS04675	COG0765	amino acid transport
IBC04_RS04695	COG1115	amino acid carrier protein
IBC04_RS04700	COG0210	DNA helicase
IBC04_RS04705	COG2873	o-acetylhomoserine
IBC04_RS04740	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IBC04_RS04745	COG0196	riboflavin kinase activity
IBC04_RS04750	COG1393	Belongs to the ArsC family
IBC04_RS04760	COG0483	inositol monophosphate 1-phosphatase activity
IBC04_RS04765	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
IBC04_RS04765	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IBC04_RS04775	COG0573	inorganic phosphate transmembrane transporter activity
IBC04_RS04780	COG0581	inorganic phosphate transmembrane transporter activity
IBC04_RS04795	COG0704	Plays a role in the regulation of phosphate uptake
IBC04_RS04810	COG0095	Lipoate-protein ligase
IBC04_RS04825	COG0058	SHG alpha-glucan phosphorylase activity
IBC04_RS04830	COG1640	4-alpha-glucanotransferase
IBC04_RS04840	COG1609	Transcriptional regulator
IBC04_RS04870	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IBC04_RS04875	COG0805	protein transport
IBC04_RS04880	COG0672	)-iron permease
IBC04_RS04885	COG2837	iron assimilation
IBC04_RS04890	COG2822	iron ion transport
IBC04_RS04895	COG4607	ABC-type enterochelin transport system periplasmic component
IBC04_RS04900	COG4604	ABC transporter, ATP-binding protein
IBC04_RS04905	COG4605	iron ion homeostasis
IBC04_RS04910	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IBC04_RS04930	COG0508	dehydrogenase complex catalyzes the overall conversion of
IBC04_RS04935	COG0022	dehydrogenase e1 component
IBC04_RS04935	COG0508	dehydrogenase complex catalyzes the overall conversion of
IBC04_RS04940	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IBC04_RS04965	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IBC04_RS04970	COG4667	esterase of the alpha-beta hydrolase superfamily
IBC04_RS05010	COG0628	permease
IBC04_RS05020	COG0561	phosphatase activity
IBC04_RS05050	COG1442	glycosyl transferase family 8
IBC04_RS05050	COG1216	Glycosyl transferase, family 2
IBC04_RS05070	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IBC04_RS05090	COG2244	polysaccharide biosynthetic process
IBC04_RS05100	COG1216	Glycosyl transferase, family 2
IBC04_RS05100	COG1442	glycosyl transferase family 8
IBC04_RS05105	COG1442	glycosyl transferase family 8
IBC04_RS05155	COG1316	TRANSCRIPTIONal
IBC04_RS05175	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IBC04_RS05185	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IBC04_RS05205	COG1573	uracil-dna glycosylase
IBC04_RS05270	COG0681	Belongs to the peptidase S26 family
IBC04_RS05280	COG0628	permease
IBC04_RS05285	COG1051	belongs to the nudix hydrolase family
IBC04_RS05290	COG2177	Part of the ABC transporter FtsEX involved in
IBC04_RS05295	COG2884	Cell division ATP-binding protein ftsE
IBC04_RS05305	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IBC04_RS05340	COG2348	transferase activity, transferring amino-acyl groups
IBC04_RS05350	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IBC04_RS05355	COG5002	protein histidine kinase activity
IBC04_RS05360	COG0745	RESPONSE REGULATOR receiver
IBC04_RS05365	COG1126	abc transporter atp-binding protein
IBC04_RS05370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBC04_RS05375	COG0765	amino acid transport
IBC04_RS05380	COG0765	amino acid transport
IBC04_RS05405	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IBC04_RS05415	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IBC04_RS05420	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IBC04_RS05420	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IBC04_RS05430	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IBC04_RS05435	COG1956	GAF domain-containing protein
IBC04_RS05440	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IBC04_RS05455	COG0335	large ribosomal subunit rRNA binding
IBC04_RS05460	COG0038	chloride channel
IBC04_RS05470	COG0038	chloride channel
IBC04_RS05475	COG0716	FMN binding
IBC04_RS05535	COG3328	transposase activity
IBC04_RS05545	COG0469	pyruvate kinase activity
IBC04_RS05595	COG0167	dihydroorotate dehydrogenase activity
IBC04_RS05605	COG0776	regulation of translation
IBC04_RS05615	COG2755	lipolytic protein G-D-S-L family
IBC04_RS05620	COG1307	EDD domain protein, DegV family
IBC04_RS05625	COG0497	DNA recombination
IBC04_RS05630	COG1438	arginine binding
IBC04_RS05635	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
IBC04_RS05660	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IBC04_RS05670	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IBC04_RS05680	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IBC04_RS05680	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IBC04_RS05685	COG0300	oxidoreductase activity
IBC04_RS05700	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IBC04_RS05705	COG0772	Belongs to the SEDS family
IBC04_RS05720	COG0107	imidazoleglycerol-phosphate synthase activity
IBC04_RS05730	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IBC04_RS05740	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IBC04_RS05790	COG0647	UMP catabolic process
IBC04_RS05800	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IBC04_RS05825	COG1088	dTDP-glucose 4,6-dehydratase activity
IBC04_RS05835	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IBC04_RS05840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IBC04_RS05855	COG2384	SAM-dependent methyltransferase
IBC04_RS05880	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IBC04_RS05885	COG3442	glutamine amidotransferase
IBC04_RS05890	COG0392	lysyltransferase activity
IBC04_RS05890	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IBC04_RS05900	COG0488	(ABC) transporter
IBC04_RS05910	COG0513	Belongs to the DEAD box helicase family
IBC04_RS05945	COG0372	Belongs to the citrate synthase family
IBC04_RS05950	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IBC04_RS05955	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IBC04_RS05960	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IBC04_RS05965	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IBC04_RS05990	COG0346	lactoylglutathione lyase activity
IBC04_RS06015	COG0488	(ABC) transporter
IBC04_RS06040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IBC04_RS06045	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IBC04_RS06045	COG1328	CTP reductase activity
IBC04_RS06070	COG1196	nuclear chromosome segregation
IBC04_RS06085	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IBC04_RS06100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IBC04_RS06110	COG1011	Hydrolase
IBC04_RS06120	COG1760	l-serine dehydratase
IBC04_RS06125	COG1760	l-serine dehydratase
IBC04_RS06155	COG4585	Histidine kinase
IBC04_RS06165	COG1131	(ABC) transporter
IBC04_RS06205	COG3328	transposase activity
IBC04_RS06240	COG0577	efflux transmembrane transporter activity
IBC04_RS06245	COG1136	(ABC) transporter
IBC04_RS06250	COG0784	Response regulator, receiver
IBC04_RS06250	COG2198	Histidine kinase
IBC04_RS06250	COG5002	protein histidine kinase activity
IBC04_RS06255	COG0745	RESPONSE REGULATOR receiver
IBC04_RS06270	COG0534	Mate efflux family protein
IBC04_RS06275	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IBC04_RS06275	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IBC04_RS06290	COG1126	abc transporter atp-binding protein
IBC04_RS06295	COG0765	amino acid transport
IBC04_RS06305	COG2079	MmgE PrpD family protein
IBC04_RS06310	COG0436	Aminotransferase
IBC04_RS06345	COG0531	amino acid
IBC04_RS06365	COG1126	abc transporter atp-binding protein
IBC04_RS06370	COG0765	amino acid transport
IBC04_RS06375	COG0765	amino acid transport
IBC04_RS06380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBC04_RS06390	COG0386	Belongs to the glutathione peroxidase family
IBC04_RS06425	COG2514	catechol 2,3-dioxygenase activity
IBC04_RS06430	COG1959	2 iron, 2 sulfur cluster binding
IBC04_RS06440	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IBC04_RS06440	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IBC04_RS06445	COG0778	Nitroreductase
IBC04_RS06455	COG0656	L-ascorbic acid biosynthetic process
IBC04_RS06460	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IBC04_RS06495	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IBC04_RS06520	COG1280	lysine exporter protein (LysE YggA)
IBC04_RS06530	COG1216	Glycosyl transferase, family 2
IBC04_RS06530	COG1442	glycosyl transferase family 8
IBC04_RS06535	COG0577	efflux transmembrane transporter activity
IBC04_RS06590	COG1396	sequence-specific DNA binding
IBC04_RS06610	COG0419	ATPase involved in DNA repair
IBC04_RS06625	COG3250	beta-galactosidase activity
IBC04_RS06630	COG2211	Major facilitator Superfamily
IBC04_RS06630	COG2190	(PTS) system
IBC04_RS06635	COG2017	converts alpha-aldose to the beta-anomer
IBC04_RS06640	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IBC04_RS06655	COG1609	Transcriptional regulator
IBC04_RS06680	COG0488	(ABC) transporter
IBC04_RS06745	COG2197	response regulator
IBC04_RS06750	COG4585	Histidine kinase
IBC04_RS06765	COG2815	serine threonine protein kinase
IBC04_RS06765	COG0515	serine threonine protein kinase
IBC04_RS06775	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IBC04_RS06775	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IBC04_RS06785	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IBC04_RS06800	COG0552	protein localization to endoplasmic reticulum
IBC04_RS06805	COG0561	phosphatase activity
IBC04_RS06810	COG0561	phosphatase activity
IBC04_RS06815	COG1725	Transcriptional regulator
IBC04_RS06820	COG1131	(ABC) transporter
IBC04_RS06830	COG4608	Belongs to the ABC transporter superfamily
IBC04_RS06835	COG0444	Belongs to the ABC transporter superfamily
IBC04_RS06840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IBC04_RS06845	COG0601	transmembrane transport
IBC04_RS06850	COG4166	transmembrane transport
IBC04_RS06860	COG4166	transmembrane transport
IBC04_RS06875	COG4608	Belongs to the ABC transporter superfamily
IBC04_RS06880	COG4608	Belongs to the ABC transporter superfamily
IBC04_RS06885	COG0084	hydrolase, TatD family'
IBC04_RS06890	COG2223	nitrite transmembrane transporter activity
IBC04_RS06900	COG0280	phosphate acetyltransferase
IBC04_RS06905	COG0564	pseudouridine synthase activity
IBC04_RS06915	COG2357	RelA SpoT domain protein
IBC04_RS06930	COG1104	cysteine desulfurase activity
IBC04_RS06950	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IBC04_RS06955	COG2003	Belongs to the UPF0758 family
IBC04_RS06980	COG1215	transferase activity, transferring glycosyl groups
IBC04_RS06990	COG1442	glycosyl transferase family 8
IBC04_RS06990	COG1216	Glycosyl transferase, family 2
IBC04_RS07010	COG1091	dTDP-4-dehydrorhamnose reductase activity
IBC04_RS07020	COG0463	Glycosyl transferase, family 2
IBC04_RS07030	COG2151	metal-sulfur cluster biosynthetic enzyme
IBC04_RS07035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IBC04_RS07040	COG0358	DNA primase activity
IBC04_RS07060	COG0436	Aminotransferase
IBC04_RS07065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBC04_RS07070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBC04_RS07075	COG1051	belongs to the nudix hydrolase family
IBC04_RS07095	COG0765	amino acid transport
IBC04_RS07100	COG1126	abc transporter atp-binding protein
IBC04_RS07120	COG1187	pseudouridine synthase activity
IBC04_RS07165	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IBC04_RS07170	COG1518	maintenance of DNA repeat elements
IBC04_RS07175	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
IBC04_RS07185	COG0560	Phosphoserine phosphatase
IBC04_RS07195	COG0187	DNA topoisomerase II activity
IBC04_RS07205	COG1346	cytolysis
IBC04_RS07210	COG1380	Effector of murein hydrolase LrgA
IBC04_RS07220	COG1393	Belongs to the ArsC family
IBC04_RS07230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IBC04_RS07265	COG1177	transmembrane transport
IBC04_RS07270	COG1176	ABC-type spermidine putrescine transport system, permease component I
IBC04_RS07310	COG0531	amino acid
IBC04_RS07315	COG0285	dihydrofolate synthase activity
IBC04_RS07320	COG1837	Belongs to the UPF0109 family
IBC04_RS07330	COG3615	Tellurite resistance protein tehB
IBC04_RS07330	COG0500	methyltransferase
IBC04_RS07340	COG0708	Exodeoxyribonuclease III
IBC04_RS07355	COG1597	lipid kinase activity
IBC04_RS07365	COG4708	membrane
IBC04_RS07375	COG0024	Methionine aminopeptidase
IBC04_RS07380	COG4109	DRTGG domain
IBC04_RS07390	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IBC04_RS07395	COG2333	competence protein COMEC
IBC04_RS07395	COG0658	competence protein
IBC04_RS07400	COG1596	polysaccharide export
IBC04_RS07400	COG1555	photosystem II stabilization
IBC04_RS07405	COG0204	Acyl-transferase
IBC04_RS07415	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IBC04_RS07425	COG0513	Belongs to the DEAD box helicase family
IBC04_RS07445	COG1396	sequence-specific DNA binding
IBC04_RS07450	COG2211	Major facilitator Superfamily
IBC04_RS07465	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IBC04_RS07480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBC04_RS07485	COG1126	abc transporter atp-binding protein
IBC04_RS07490	COG0765	amino acid transport
IBC04_RS07495	COG0765	amino acid transport
IBC04_RS07510	COG2217	Heavy metal translocating P-type atpase
IBC04_RS07520	COG0159	tryptophan synthase activity
IBC04_RS07530	COG0135	phosphoribosylanthranilate isomerase activity
IBC04_RS07545	COG0512	Glutamine amidotransferase of anthranilate synthase
IBC04_RS07550	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IBC04_RS07555	COG1605	Chorismate mutase
IBC04_RS07555	COG0287	Prephenate dehydrogenase
IBC04_RS07565	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IBC04_RS07590	COG2176	DNA-directed DNA polymerase activity
IBC04_RS07600	COG2151	metal-sulfur cluster biosynthetic enzyme
IBC04_RS07610	COG2081	HI0933 family
IBC04_RS07635	COG1131	(ABC) transporter
IBC04_RS07640	COG0537	adenosine 5'-monophosphoramidase activity
IBC04_RS07660	COG3328	transposase activity
IBC04_RS07675	COG2226	methyltransferase
IBC04_RS07680	COG0799	negative regulation of ribosome biogenesis
IBC04_RS07685	COG1713	HD superfamily hydrolase involved in NAD metabolism
IBC04_RS07690	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IBC04_RS07695	COG1534	Rna-binding protein
IBC04_RS07700	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IBC04_RS07705	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
IBC04_RS07760	COG1335	isochorismatase
IBC04_RS07770	COG0436	Aminotransferase
IBC04_RS07775	COG0589	response to stress
IBC04_RS07795	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IBC04_RS07805	COG1253	flavin adenine dinucleotide binding
IBC04_RS07810	COG1119	ATPase activity
IBC04_RS07820	COG0025	NhaP-type Na H and K H
IBC04_RS07830	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
IBC04_RS07835	COG1242	4 iron, 4 sulfur cluster binding
IBC04_RS07840	COG3480	Lon protease (S16) C-terminal proteolytic domain
IBC04_RS07845	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IBC04_RS07850	COG0742	ribosomal rna small subunit methyltransferase
IBC04_RS07855	COG0492	ferredoxin-NADP+ reductase activity
IBC04_RS07865	COG1126	abc transporter atp-binding protein
IBC04_RS07875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBC04_RS07890	COG1882	Formate acetyltransferase
IBC04_RS07915	COG0390	transport system, permease component
IBC04_RS07920	COG4619	ABC transporter
IBC04_RS07925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IBC04_RS07940	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IBC04_RS08005	COG3290	protein histidine kinase activity
IBC04_RS08015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IBC04_RS08020	COG2274	protein secretion by the type I secretion system
IBC04_RS08025	COG2274	protein secretion by the type I secretion system
IBC04_RS08030	COG1132	(ABC) transporter
IBC04_RS08035	COG1132	(ABC) transporter
IBC04_RS08050	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IBC04_RS08055	COG4470	Protein conserved in bacteria
IBC04_RS08060	COG0737	Belongs to the 5'-nucleotidase family
IBC04_RS08070	COG0513	Belongs to the DEAD box helicase family
IBC04_RS08080	COG0768	penicillin binding
IBC04_RS08110	COG3152	Membrane
IBC04_RS08120	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IBC04_RS08135	COG4152	abc transporter atp-binding protein
IBC04_RS08140	COG1811	Na channel or pump
IBC04_RS08180	COG0561	phosphatase activity
IBC04_RS08185	COG0252	asparaginase activity
IBC04_RS08190	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IBC04_RS08205	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IBC04_RS08210	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IBC04_RS08225	COG1482	cell wall glycoprotein biosynthetic process
IBC04_RS08230	COG1940	carbohydrate kinase activity
IBC04_RS08235	COG2190	(PTS) system
IBC04_RS08235	COG1263	PTS System
IBC04_RS08235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IBC04_RS08240	COG1621	beta-fructofuranosidase activity
IBC04_RS08245	COG1609	Transcriptional regulator
IBC04_RS08265	COG2131	deaminase
IBC04_RS08270	COG0006	proline dipeptidase activity
IBC04_RS08285	COG1131	(ABC) transporter
IBC04_RS08365	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IBC04_RS08365	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IBC04_RS08390	COG0681	Belongs to the peptidase S26 family
IBC04_RS08395	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IBC04_RS08405	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IBC04_RS08415	COG0456	acetyltransferase
IBC04_RS08420	COG1214	PFAM Peptidase M22, glycoprotease
IBC04_RS08440	COG0174	glutamine synthetase
IBC04_RS08445	COG0789	Transcriptional regulator
IBC04_RS08500	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IBC04_RS08545	COG0084	hydrolase, TatD family'
IBC04_RS08550	COG1832	CoA-binding protein
IBC04_RS08555	COG3118	belongs to the thioredoxin family
IBC04_RS08700	COG0756	dUTP diphosphatase activity
IBC04_RS08730	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IBC04_RS08740	COG0457	Tetratricopeptide repeat
IBC04_RS08740	COG0705	Rhomboid family
IBC04_RS08745	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IBC04_RS08765	COG2226	methyltransferase
IBC04_RS08790	COG0425	Belongs to the sulfur carrier protein TusA family
IBC04_RS08795	COG2391	methyltransferase activity
IBC04_RS08800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IBC04_RS08805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IBC04_RS08815	COG1363	Peptidase, m42
IBC04_RS08820	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IBC04_RS08825	COG1266	CAAX protease self-immunity
IBC04_RS08880	COG1459	type II secretion system
IBC04_RS08885	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IBC04_RS08920	COG0440	acetolactate synthase activity
IBC04_RS08925	COG0028	Belongs to the TPP enzyme family
IBC04_RS08935	COG1461	Dihydroxyacetone kinase
IBC04_RS08945	COG0534	Mate efflux family protein
IBC04_RS08960	COG1012	belongs to the aldehyde dehydrogenase family
IBC04_RS08960	COG1454	alcohol dehydrogenase
IBC04_RS08965	COG1012	belongs to the aldehyde dehydrogenase family
IBC04_RS08965	COG1454	alcohol dehydrogenase
IBC04_RS08970	COG1454	alcohol dehydrogenase
IBC04_RS08970	COG1012	belongs to the aldehyde dehydrogenase family
IBC04_RS08980	COG1012	belongs to the aldehyde dehydrogenase family
IBC04_RS08980	COG1454	alcohol dehydrogenase
IBC04_RS08985	COG3590	peptidase
IBC04_RS09000	COG1609	Transcriptional regulator
IBC04_RS09005	COG2188	Transcriptional regulator
IBC04_RS09010	COG4475	Protein of unknown function (DUF436)
IBC04_RS09040	COG1301	dicarboxylic acid transport
IBC04_RS09110	COG0191	fructose-bisphosphate aldolase activity
IBC04_RS09180	COG0201	protein transport
IBC04_RS09340	COG1132	(ABC) transporter
IBC04_RS09365	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IBC04_RS09395	COG1328	CTP reductase activity
IBC04_RS09405	COG0602	queuosine metabolic process
IBC04_RS09415	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IBC04_RS09440	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IBC04_RS09450	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IBC04_RS09460	COG0827	DNA restriction-modification system
IBC04_RS09465	COG0827	DNA restriction-modification system
IBC04_RS09510	COG4974	Belongs to the 'phage' integrase family
IBC04_RS09525	COG1597	lipid kinase activity
IBC04_RS09540	COG2261	transglycosylase associated protein
IBC04_RS09560	COG3237	CsbD-like
IBC04_RS09590	COG1511	domain protein
IBC04_RS09590	COG1511	domain protein
IBC04_RS09600	COG3759	membrane
IBC04_RS09695	COG0305	Participates in initiation and elongation during chromosome replication
IBC04_RS09715	COG0494	nUDIX hydrolase
IBC04_RS09730	COG0741	lytic transglycosylase activity
IBC04_RS09735	COG1388	LysM domain
IBC04_RS09735	COG3584	3D domain protein
IBC04_RS09740	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IBC04_RS09755	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IBC04_RS09765	COG0612	Peptidase, M16
IBC04_RS09795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IBC04_RS09800	COG0488	(ABC) transporter
IBC04_RS09835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IBC04_RS09840	COG1475	DNA binding