locus-tag	class	description
IBC08_RS00010	COG0592	DNA-directed DNA polymerase activity
IBC08_RS00020	COG0012	GTP binding
IBC08_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IBC08_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IBC08_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IBC08_RS00195	COG3942	CHAP domain
IBC08_RS00210	COG0436	Aminotransferase
IBC08_RS00225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IBC08_RS00235	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IBC08_RS00250	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IBC08_RS00265	COG1388	LysM domain
IBC08_RS00265	COG3942	CHAP domain
IBC08_RS00270	COG0151	Belongs to the GarS family
IBC08_RS00275	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IBC08_RS00295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IBC08_RS00315	COG4550	Control of competence regulator ComK, YlbF/YmcA
IBC08_RS00360	COG2818	Glycosylase
IBC08_RS00370	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IBC08_RS00375	COG1393	Belongs to the ArsC family
IBC08_RS00480	COG0431	NADPH-dependent FMN reductase
IBC08_RS00520	COG4463	regulation of RNA biosynthetic process
IBC08_RS00525	COG0542	response to heat
IBC08_RS00535	COG1686	Belongs to the peptidase S11 family
IBC08_RS00550	COG1045	serine acetyltransferase
IBC08_RS00560	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
IBC08_RS00580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IBC08_RS00605	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IBC08_RS00690	COG2189	Belongs to the N(4) N(6)-methyltransferase family
IBC08_RS00695	COG3421	Type III restriction
IBC08_RS00720	COG1705	Flagellar rod assembly protein muramidase FlgJ
IBC08_RS00720	COG3942	CHAP domain
IBC08_RS00735	COG3830	Belongs to the UPF0237 family
IBC08_RS00750	COG1876	peptidase activity
IBC08_RS00785	COG0351	phosphomethylpyrimidine kinase
IBC08_RS00885	COG4166	transmembrane transport
IBC08_RS00910	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IBC08_RS00930	COG0668	transmembrane transport
IBC08_RS00945	COG0504	CTP synthase activity
IBC08_RS00955	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IBC08_RS00965	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IBC08_RS01005	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IBC08_RS01045	COG1126	abc transporter atp-binding protein
IBC08_RS01050	COG0765	amino acid transport
IBC08_RS01055	COG1968	undecaprenyl-diphosphatase activity
IBC08_RS01070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IBC08_RS01080	COG0719	Fe-S assembly protein
IBC08_RS01085	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IBC08_RS01095	COG0719	Fe-S assembly protein
IBC08_RS01135	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IBC08_RS01150	COG1121	(ABC) transporter
IBC08_RS01155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IBC08_RS01195	COG4589	Belongs to the CDS family
IBC08_RS01210	COG4120	Belongs to the binding-protein-dependent transport system permease family
IBC08_RS01215	COG1116	anion transmembrane transporter activity
IBC08_RS01215	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IBC08_RS01255	COG0564	pseudouridine synthase activity
IBC08_RS01260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IBC08_RS01290	COG1349	DNA-binding transcription factor activity
IBC08_RS01310	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IBC08_RS01325	COG3579	cysteine-type endopeptidase activity
IBC08_RS01335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IBC08_RS01360	COG0116	Belongs to the methyltransferase superfamily
IBC08_RS01370	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IBC08_RS01390	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IBC08_RS01410	COG1254	Belongs to the acylphosphatase family
IBC08_RS01415	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IBC08_RS01455	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IBC08_RS01475	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IBC08_RS01480	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IBC08_RS01485	COG1187	pseudouridine synthase activity
IBC08_RS01495	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IBC08_RS01500	COG0569	domain protein
IBC08_RS01510	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
IBC08_RS01515	COG0671	phosphoesterase, PA-phosphatase related
IBC08_RS01575	COG0829	nickel cation binding
IBC08_RS01580	COG0310	cobalt ion transport
IBC08_RS01590	COG1122	ATPase activity
IBC08_RS01595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBC08_RS01600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IBC08_RS01620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBC08_RS01625	COG1464	Belongs to the NlpA lipoprotein family
IBC08_RS01650	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IBC08_RS01675	COG1122	ATPase activity
IBC08_RS01685	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IBC08_RS01695	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IBC08_RS01710	COG0745	RESPONSE REGULATOR receiver
IBC08_RS01715	COG5002	protein histidine kinase activity
IBC08_RS01730	COG1484	DNA-dependent DNA replication
IBC08_RS01770	COG3716	PTS system mannose fructose sorbose family IID component
IBC08_RS01775	COG3715	PTS system
IBC08_RS01785	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IBC08_RS01790	COG0561	phosphatase activity
IBC08_RS01795	COG2252	PERMEase
IBC08_RS01800	COG0802	atpase or kinase
IBC08_RS01805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IBC08_RS01810	COG1316	TRANSCRIPTIONal
IBC08_RS01820	COG0195	Participates in both transcription termination and antitermination
IBC08_RS01825	COG2740	Nucleic-acid-binding protein implicated in transcription termination
IBC08_RS01835	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IBC08_RS01860	COG2244	polysaccharide biosynthetic process
IBC08_RS01865	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IBC08_RS01870	COG0626	cystathionine gamma-synthase activity
IBC08_RS01875	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IBC08_RS01905	COG4471	UPF0298 protein
IBC08_RS01915	COG0559	Belongs to the binding-protein-dependent transport system permease family
IBC08_RS01945	COG1739	Uncharacterized protein family UPF0029
IBC08_RS01950	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
IBC08_RS01955	COG1040	competence protein
IBC08_RS02045	COG0527	aspartate kinase activity
IBC08_RS02050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IBC08_RS02055	COG1024	Enoyl-CoA hydratase
IBC08_RS02060	COG1846	Transcriptional regulator
IBC08_RS02080	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IBC08_RS02085	COG1028	Short-chain dehydrogenase reductase Sdr
IBC08_RS02090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IBC08_RS02105	COG0439	Biotin carboxylase
IBC08_RS02130	COG0076	glutamate decarboxylase activity
IBC08_RS02135	COG0531	amino acid
IBC08_RS02195	COG1349	DNA-binding transcription factor activity
IBC08_RS02200	COG1105	Belongs to the carbohydrate kinase PfkB family
IBC08_RS02205	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IBC08_RS02205	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IBC08_RS02205	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IBC08_RS02210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IBC08_RS02215	COG0285	dihydrofolate synthase activity
IBC08_RS02225	COG1104	cysteine desulfurase activity
IBC08_RS02285	COG0488	(ABC) transporter
IBC08_RS02305	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IBC08_RS02310	COG0242	peptide deformylase activity
IBC08_RS02370	COG1702	phosphate starvation-inducible protein PhoH
IBC08_RS02395	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IBC08_RS02395	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IBC08_RS02415	COG4122	O-methyltransferase activity
IBC08_RS02420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IBC08_RS02450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IBC08_RS02455	COG0436	Aminotransferase
IBC08_RS02470	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IBC08_RS02475	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IBC08_RS02480	COG0726	polysaccharide deacetylase
IBC08_RS02495	COG2962	Rard protein
IBC08_RS02525	COG0525	valine-tRNA ligase activity
IBC08_RS02540	COG0356	it plays a direct role in the translocation of protons across the membrane
IBC08_RS02575	COG0772	Belongs to the SEDS family
IBC08_RS02595	COG0470	DNA polymerase III
IBC08_RS02600	COG1774	PSP1 C-terminal conserved region
IBC08_RS02605	COG4467	Involved in initiation control of chromosome replication
IBC08_RS02615	COG0004	ammonium transporteR
IBC08_RS02620	COG0347	Belongs to the P(II) protein family
IBC08_RS02625	COG1705	Flagellar rod assembly protein muramidase FlgJ
IBC08_RS02625	COG1388	LysM domain
IBC08_RS02670	COG1113	amino acid transport
IBC08_RS02710	COG0583	DNA-binding transcription factor activity
IBC08_RS02720	COG0564	pseudouridine synthase activity
IBC08_RS02740	COG0505	Belongs to the CarA family
IBC08_RS02785	COG1132	(ABC) transporter
IBC08_RS02805	COG3279	Response regulator of the LytR AlgR family
IBC08_RS02815	COG1131	(ABC) transporter
IBC08_RS02850	COG1187	pseudouridine synthase activity
IBC08_RS02855	COG1473	amidohydrolase
IBC08_RS02860	COG0686	Belongs to the AlaDH PNT family
IBC08_RS02865	COG0686	Belongs to the AlaDH PNT family
IBC08_RS02870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IBC08_RS02940	COG0438	transferase activity, transferring glycosyl groups
IBC08_RS02975	COG1272	protein, Hemolysin III
IBC08_RS02990	COG3425	synthase
IBC08_RS03000	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IBC08_RS03020	COG0833	amino acid
IBC08_RS03025	COG2040	homocysteine
IBC08_RS03045	COG0187	DNA topoisomerase II activity
IBC08_RS03055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IBC08_RS03075	COG0539	negative regulation of cytoplasmic translation
IBC08_RS03115	COG0494	nUDIX hydrolase
IBC08_RS03120	COG0542	response to heat
IBC08_RS03125	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IBC08_RS03130	COG4703	Protein of unknown function (DUF1797)
IBC08_RS03135	COG0765	amino acid transport
IBC08_RS03190	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IBC08_RS03195	COG0768	penicillin binding
IBC08_RS03200	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IBC08_RS03215	COG3711	transcriptional antiterminator
IBC08_RS03225	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IBC08_RS03230	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IBC08_RS03235	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IBC08_RS03240	COG0237	dephospho-CoA kinase activity
IBC08_RS03245	COG2814	Major facilitator Superfamily
IBC08_RS03260	COG0557	exoribonuclease II activity
IBC08_RS03275	COG1185	polyribonucleotide nucleotidyltransferase activity
IBC08_RS03280	COG0006	proline dipeptidase activity
IBC08_RS03285	COG1609	Transcriptional regulator
IBC08_RS03320	COG1368	sulfuric ester hydrolase activity
IBC08_RS03325	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IBC08_RS03350	COG0287	Prephenate dehydrogenase
IBC08_RS03375	COG0077	Prephenate dehydratase
IBC08_RS03435	COG1518	maintenance of DNA repeat elements
IBC08_RS03440	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IBC08_RS03450	COG3689	TIGRFAM TIGR03943 family protein
IBC08_RS03455	COG0701	Predicted permease
IBC08_RS03460	COG2183	response to ionizing radiation
IBC08_RS03505	COG0826	peptidase U32
IBC08_RS03515	COG1268	BioY protein
IBC08_RS03525	COG4443	Transcriptional Coactivator p15 (PC4)
IBC08_RS03530	COG1914	H( )-stimulated, divalent metal cation uptake system
IBC08_RS03565	COG1388	LysM domain
IBC08_RS03565	COG1705	Flagellar rod assembly protein muramidase FlgJ
IBC08_RS03580	COG0406	alpha-ribazole phosphatase activity
IBC08_RS03585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IBC08_RS03620	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IBC08_RS03630	COG0732	type I restriction modification DNA specificity domain
IBC08_RS03645	COG1704	LemA family
IBC08_RS03650	COG0501	Belongs to the peptidase M48B family
IBC08_RS03665	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IBC08_RS03675	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IBC08_RS03685	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IBC08_RS03690	COG0783	Belongs to the Dps family
IBC08_RS03695	COG0735	belongs to the Fur family
IBC08_RS03700	COG4483	Protein conserved in bacteria
IBC08_RS03705	COG1940	carbohydrate kinase activity
IBC08_RS03710	COG1217	gtp-binding protein TYPA
IBC08_RS03745	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IBC08_RS03770	COG3599	regulation of cell shape
IBC08_RS03800	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IBC08_RS03805	COG0625	glutathione transferase activity
IBC08_RS03810	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IBC08_RS03825	COG2890	protein-(glutamine-N5) methyltransferase activity
IBC08_RS03855	COG1132	(ABC) transporter
IBC08_RS03870	COG1696	Membrane protein involved in D-alanine export
IBC08_RS03880	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
IBC08_RS03890	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IBC08_RS03895	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IBC08_RS03920	COG0582	viral genome integration into host DNA
IBC08_RS03990	COG0582	viral genome integration into host DNA
IBC08_RS04010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IBC08_RS04015	COG4684	Psort location CytoplasmicMembrane, score
IBC08_RS04020	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IBC08_RS04070	COG2813	Specifically methylates the guanine in position
IBC08_RS04090	COG1744	ABC transporter substrate-binding protein PnrA-like
IBC08_RS04095	COG3845	ABC transporter
IBC08_RS04100	COG4603	Belongs to the binding-protein-dependent transport system permease family
IBC08_RS04105	COG1079	Belongs to the binding-protein-dependent transport system permease family
IBC08_RS04115	COG1199	ATP-dependent helicase activity
IBC08_RS04115	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IBC08_RS04125	COG0436	Aminotransferase
IBC08_RS04145	COG0251	oxidation-reduction process
IBC08_RS04155	COG0720	synthase
IBC08_RS04210	COG1278	Cold shock
IBC08_RS04230	COG2217	Heavy metal translocating P-type atpase
IBC08_RS04245	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IBC08_RS04250	COG0626	cystathionine gamma-synthase activity
IBC08_RS04255	COG1045	serine acetyltransferase
IBC08_RS04280	COG4975	Glucose uptake
IBC08_RS04300	COG0803	Belongs to the bacterial solute-binding protein 9 family
IBC08_RS04300	COG3443	Belongs to the bacterial solute-binding protein 9 family
IBC08_RS04315	COG3942	CHAP domain
IBC08_RS04315	COG1705	Flagellar rod assembly protein muramidase FlgJ
IBC08_RS04330	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IBC08_RS04335	COG2824	Alkylphosphonate utilization operon protein PhnA
IBC08_RS04340	COG0765	amino acid transport
IBC08_RS04345	COG1126	abc transporter atp-binding protein
IBC08_RS04350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBC08_RS04360	COG1064	alcohol dehydrogenase
IBC08_RS04365	COG1064	alcohol dehydrogenase
IBC08_RS04375	COG3421	Type III restriction
IBC08_RS04380	COG2189	Belongs to the N(4) N(6)-methyltransferase family
IBC08_RS04385	COG0519	Catalyzes the synthesis of GMP from XMP
IBC08_RS04385	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IBC08_RS04390	COG2188	Transcriptional regulator
IBC08_RS04400	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IBC08_RS04410	COG1827	regulation of RNA biosynthetic process
IBC08_RS04420	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IBC08_RS04430	COG1940	carbohydrate kinase activity
IBC08_RS04435	COG0758	DNA mediated transformation
IBC08_RS04440	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IBC08_RS04510	COG1396	sequence-specific DNA binding
IBC08_RS04525	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IBC08_RS04530	COG0010	Belongs to the arginase family
IBC08_RS04540	COG0028	Belongs to the TPP enzyme family
IBC08_RS04545	COG3527	Alpha-acetolactate decarboxylase
IBC08_RS04560	COG1230	cation diffusion facilitator family transporter
IBC08_RS04595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IBC08_RS04615	COG1293	RNA-binding protein homologous to eukaryotic snRNP
IBC08_RS04630	COG0047	phosphoribosylformylglycinamidine synthase activity
IBC08_RS04640	COG0167	dihydroorotate dehydrogenase activity
IBC08_RS04650	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IBC08_RS04670	COG1337	RAMP superfamily
IBC08_RS04675	COG1567	CRISPR-associated RAMP protein, Csm4 family
IBC08_RS04690	COG0284	orotidine-5'-phosphate decarboxylase activity
IBC08_RS04705	COG3104	oligopeptide transport
IBC08_RS04710	COG0154	amidase activity
IBC08_RS04715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBC08_RS04720	COG0765	amino acid transport
IBC08_RS04730	COG0737	Belongs to the 5'-nucleotidase family
IBC08_RS04755	COG1115	amino acid carrier protein
IBC08_RS04765	COG2873	o-acetylhomoserine
IBC08_RS04800	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IBC08_RS04805	COG0196	riboflavin kinase activity
IBC08_RS04810	COG1393	Belongs to the ArsC family
IBC08_RS04820	COG0483	inositol monophosphate 1-phosphatase activity
IBC08_RS04825	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IBC08_RS04825	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
IBC08_RS04835	COG0573	inorganic phosphate transmembrane transporter activity
IBC08_RS04840	COG0581	inorganic phosphate transmembrane transporter activity
IBC08_RS04855	COG0704	Plays a role in the regulation of phosphate uptake
IBC08_RS04870	COG0095	Lipoate-protein ligase
IBC08_RS04885	COG0058	SHG alpha-glucan phosphorylase activity
IBC08_RS04890	COG1640	4-alpha-glucanotransferase
IBC08_RS04910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IBC08_RS04915	COG0805	protein transport
IBC08_RS04920	COG0672	)-iron permease
IBC08_RS04925	COG2837	iron assimilation
IBC08_RS04930	COG2822	iron ion transport
IBC08_RS04935	COG4607	ABC-type enterochelin transport system periplasmic component
IBC08_RS04940	COG4604	ABC transporter, ATP-binding protein
IBC08_RS04945	COG4605	iron ion homeostasis
IBC08_RS04950	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IBC08_RS04970	COG0508	dehydrogenase complex catalyzes the overall conversion of
IBC08_RS04975	COG0022	dehydrogenase e1 component
IBC08_RS04975	COG0508	dehydrogenase complex catalyzes the overall conversion of
IBC08_RS04980	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IBC08_RS05005	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IBC08_RS05015	COG4667	esterase of the alpha-beta hydrolase superfamily
IBC08_RS05050	COG0628	permease
IBC08_RS05055	COG0406	alpha-ribazole phosphatase activity
IBC08_RS05070	COG0561	phosphatase activity
IBC08_RS05100	COG1442	glycosyl transferase family 8
IBC08_RS05100	COG1216	Glycosyl transferase, family 2
IBC08_RS05120	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IBC08_RS05140	COG2244	polysaccharide biosynthetic process
IBC08_RS05150	COG1442	glycosyl transferase family 8
IBC08_RS05150	COG1216	Glycosyl transferase, family 2
IBC08_RS05155	COG1442	glycosyl transferase family 8
IBC08_RS05205	COG1316	TRANSCRIPTIONal
IBC08_RS05225	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IBC08_RS05235	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IBC08_RS05255	COG1573	uracil-dna glycosylase
IBC08_RS05320	COG0681	Belongs to the peptidase S26 family
IBC08_RS05330	COG0628	permease
IBC08_RS05335	COG1051	belongs to the nudix hydrolase family
IBC08_RS05340	COG2177	Part of the ABC transporter FtsEX involved in
IBC08_RS05345	COG2884	Cell division ATP-binding protein ftsE
IBC08_RS05355	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IBC08_RS05390	COG2348	transferase activity, transferring amino-acyl groups
IBC08_RS05400	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IBC08_RS05405	COG5002	protein histidine kinase activity
IBC08_RS05410	COG0745	RESPONSE REGULATOR receiver
IBC08_RS05415	COG1126	abc transporter atp-binding protein
IBC08_RS05420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBC08_RS05425	COG0765	amino acid transport
IBC08_RS05430	COG0765	amino acid transport
IBC08_RS05455	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IBC08_RS05465	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IBC08_RS05470	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IBC08_RS05470	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IBC08_RS05480	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IBC08_RS05485	COG1956	GAF domain-containing protein
IBC08_RS05490	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IBC08_RS05510	COG0335	large ribosomal subunit rRNA binding
IBC08_RS05515	COG0038	chloride channel
IBC08_RS05525	COG0038	chloride channel
IBC08_RS05530	COG0716	FMN binding
IBC08_RS05585	COG0469	pyruvate kinase activity
IBC08_RS05635	COG0167	dihydroorotate dehydrogenase activity
IBC08_RS05645	COG0776	regulation of translation
IBC08_RS05655	COG2755	lipolytic protein G-D-S-L family
IBC08_RS05660	COG1307	EDD domain protein, DegV family
IBC08_RS05665	COG0497	DNA recombination
IBC08_RS05670	COG1438	arginine binding
IBC08_RS05675	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
IBC08_RS05700	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IBC08_RS05720	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IBC08_RS05720	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IBC08_RS05725	COG0300	oxidoreductase activity
IBC08_RS05740	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IBC08_RS05745	COG0772	Belongs to the SEDS family
IBC08_RS05770	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IBC08_RS05780	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IBC08_RS05805	COG3328	transposase activity
IBC08_RS05830	COG0647	UMP catabolic process
IBC08_RS05840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IBC08_RS05865	COG1088	dTDP-glucose 4,6-dehydratase activity
IBC08_RS05875	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IBC08_RS05880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IBC08_RS05895	COG2384	SAM-dependent methyltransferase
IBC08_RS05920	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IBC08_RS05925	COG3442	glutamine amidotransferase
IBC08_RS05930	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IBC08_RS05930	COG0392	lysyltransferase activity
IBC08_RS05945	COG0488	(ABC) transporter
IBC08_RS05955	COG0513	Belongs to the DEAD box helicase family
IBC08_RS05990	COG0372	Belongs to the citrate synthase family
IBC08_RS05995	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IBC08_RS06000	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IBC08_RS06005	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IBC08_RS06010	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IBC08_RS06035	COG0346	lactoylglutathione lyase activity
IBC08_RS06040	COG3764	Sortase (surface protein transpeptidase)
IBC08_RS06060	COG0488	(ABC) transporter
IBC08_RS06085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IBC08_RS06090	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IBC08_RS06090	COG1328	CTP reductase activity
IBC08_RS06115	COG1196	nuclear chromosome segregation
IBC08_RS06130	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IBC08_RS06150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IBC08_RS06160	COG1011	Hydrolase
IBC08_RS06165	COG1268	BioY protein
IBC08_RS06175	COG0517	IMP dehydrogenase activity
IBC08_RS06175	COG1125	glycine betaine transport
IBC08_RS06190	COG2986	histidine ammonia-lyase
IBC08_RS06200	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IBC08_RS06210	COG2197	response regulator
IBC08_RS06215	COG4585	Histidine kinase
IBC08_RS06225	COG1131	(ABC) transporter
IBC08_RS06265	COG3328	transposase activity
IBC08_RS06300	COG0577	efflux transmembrane transporter activity
IBC08_RS06305	COG1136	(ABC) transporter
IBC08_RS06310	COG2198	Histidine kinase
IBC08_RS06310	COG5002	protein histidine kinase activity
IBC08_RS06310	COG0784	Response regulator, receiver
IBC08_RS06315	COG0745	RESPONSE REGULATOR receiver
IBC08_RS06330	COG0534	Mate efflux family protein
IBC08_RS06335	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IBC08_RS06335	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IBC08_RS06360	COG0531	amino acid
IBC08_RS06370	COG2514	catechol 2,3-dioxygenase activity
IBC08_RS06375	COG1959	2 iron, 2 sulfur cluster binding
IBC08_RS06385	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IBC08_RS06390	COG0778	Nitroreductase
IBC08_RS06400	COG0656	L-ascorbic acid biosynthetic process
IBC08_RS06405	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IBC08_RS06445	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IBC08_RS06470	COG1280	lysine exporter protein (LysE YggA)
IBC08_RS06480	COG1216	Glycosyl transferase, family 2
IBC08_RS06480	COG1442	glycosyl transferase family 8
IBC08_RS06485	COG0577	efflux transmembrane transporter activity
IBC08_RS06535	COG1396	sequence-specific DNA binding
IBC08_RS06555	COG0419	ATPase involved in DNA repair
IBC08_RS06560	COG0420	3'-5' exonuclease activity
IBC08_RS06570	COG3250	beta-galactosidase activity
IBC08_RS06575	COG2211	Major facilitator Superfamily
IBC08_RS06575	COG2190	(PTS) system
IBC08_RS06580	COG2017	converts alpha-aldose to the beta-anomer
IBC08_RS06585	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IBC08_RS06590	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
IBC08_RS06595	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IBC08_RS06600	COG1609	Transcriptional regulator
IBC08_RS06625	COG0488	(ABC) transporter
IBC08_RS06690	COG2197	response regulator
IBC08_RS06695	COG4585	Histidine kinase
IBC08_RS06710	COG2815	serine threonine protein kinase
IBC08_RS06710	COG0515	serine threonine protein kinase
IBC08_RS06720	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IBC08_RS06720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IBC08_RS06730	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IBC08_RS06745	COG0552	protein localization to endoplasmic reticulum
IBC08_RS06750	COG0561	phosphatase activity
IBC08_RS06755	COG0561	phosphatase activity
IBC08_RS06760	COG1725	Transcriptional regulator
IBC08_RS06765	COG1131	(ABC) transporter
IBC08_RS06775	COG4608	Belongs to the ABC transporter superfamily
IBC08_RS06780	COG0444	Belongs to the ABC transporter superfamily
IBC08_RS06785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IBC08_RS06790	COG0601	transmembrane transport
IBC08_RS06810	COG4608	Belongs to the ABC transporter superfamily
IBC08_RS06825	COG2223	nitrite transmembrane transporter activity
IBC08_RS06835	COG0280	phosphate acetyltransferase
IBC08_RS06840	COG0564	pseudouridine synthase activity
IBC08_RS06850	COG2357	RelA SpoT domain protein
IBC08_RS06865	COG1104	cysteine desulfurase activity
IBC08_RS06880	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IBC08_RS06885	COG2003	Belongs to the UPF0758 family
IBC08_RS06910	COG1215	transferase activity, transferring glycosyl groups
IBC08_RS06920	COG1442	glycosyl transferase family 8
IBC08_RS06920	COG1216	Glycosyl transferase, family 2
IBC08_RS06940	COG1091	dTDP-4-dehydrorhamnose reductase activity
IBC08_RS06950	COG0463	Glycosyl transferase, family 2
IBC08_RS06960	COG2151	metal-sulfur cluster biosynthetic enzyme
IBC08_RS06965	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IBC08_RS06970	COG0358	DNA primase activity
IBC08_RS06975	COG1970	mechanosensitive ion channel activity
IBC08_RS06985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBC08_RS06990	COG0436	Aminotransferase
IBC08_RS06995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBC08_RS07000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBC08_RS07005	COG1051	belongs to the nudix hydrolase family
IBC08_RS07020	COG0765	amino acid transport
IBC08_RS07025	COG1126	abc transporter atp-binding protein
IBC08_RS07045	COG1187	pseudouridine synthase activity
IBC08_RS07090	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IBC08_RS07095	COG1518	maintenance of DNA repeat elements
IBC08_RS07100	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
IBC08_RS07105	COG0560	Phosphoserine phosphatase
IBC08_RS07115	COG0187	DNA topoisomerase II activity
IBC08_RS07125	COG1346	cytolysis
IBC08_RS07130	COG1380	Effector of murein hydrolase LrgA
IBC08_RS07140	COG1393	Belongs to the ArsC family
IBC08_RS07150	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IBC08_RS07185	COG1177	transmembrane transport
IBC08_RS07190	COG1176	ABC-type spermidine putrescine transport system, permease component I
IBC08_RS07230	COG0531	amino acid
IBC08_RS07235	COG0285	dihydrofolate synthase activity
IBC08_RS07240	COG1837	Belongs to the UPF0109 family
IBC08_RS07250	COG0500	methyltransferase
IBC08_RS07250	COG3615	Tellurite resistance protein tehB
IBC08_RS07260	COG0708	Exodeoxyribonuclease III
IBC08_RS07275	COG1597	lipid kinase activity
IBC08_RS07285	COG4708	membrane
IBC08_RS07295	COG0024	Methionine aminopeptidase
IBC08_RS07300	COG4109	DRTGG domain
IBC08_RS07310	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IBC08_RS07315	COG0658	competence protein
IBC08_RS07315	COG2333	competence protein COMEC
IBC08_RS07320	COG1596	polysaccharide export
IBC08_RS07320	COG1555	photosystem II stabilization
IBC08_RS07325	COG0204	Acyl-transferase
IBC08_RS07335	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IBC08_RS07345	COG0513	Belongs to the DEAD box helicase family
IBC08_RS07365	COG1396	sequence-specific DNA binding
IBC08_RS07370	COG2211	Major facilitator Superfamily
IBC08_RS07385	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IBC08_RS07405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBC08_RS07410	COG1126	abc transporter atp-binding protein
IBC08_RS07415	COG0765	amino acid transport
IBC08_RS07420	COG0765	amino acid transport
IBC08_RS07435	COG2217	Heavy metal translocating P-type atpase
IBC08_RS07445	COG0159	tryptophan synthase activity
IBC08_RS07455	COG0135	phosphoribosylanthranilate isomerase activity
IBC08_RS07470	COG0512	Glutamine amidotransferase of anthranilate synthase
IBC08_RS07475	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IBC08_RS07490	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IBC08_RS07515	COG2176	DNA-directed DNA polymerase activity
IBC08_RS07525	COG2151	metal-sulfur cluster biosynthetic enzyme
IBC08_RS07535	COG2081	HI0933 family
IBC08_RS07560	COG1131	(ABC) transporter
IBC08_RS07565	COG0537	adenosine 5'-monophosphoramidase activity
IBC08_RS07595	COG2226	methyltransferase
IBC08_RS07600	COG0799	negative regulation of ribosome biogenesis
IBC08_RS07605	COG1713	HD superfamily hydrolase involved in NAD metabolism
IBC08_RS07610	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IBC08_RS07615	COG1534	Rna-binding protein
IBC08_RS07620	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IBC08_RS07625	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
IBC08_RS07680	COG1335	isochorismatase
IBC08_RS07690	COG0436	Aminotransferase
IBC08_RS07695	COG0589	response to stress
IBC08_RS07715	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IBC08_RS07725	COG1253	flavin adenine dinucleotide binding
IBC08_RS07730	COG1119	ATPase activity
IBC08_RS07735	COG0025	NhaP-type Na H and K H
IBC08_RS07745	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
IBC08_RS07750	COG1242	4 iron, 4 sulfur cluster binding
IBC08_RS07755	COG3480	Lon protease (S16) C-terminal proteolytic domain
IBC08_RS07760	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IBC08_RS07765	COG0742	ribosomal rna small subunit methyltransferase
IBC08_RS07770	COG0492	ferredoxin-NADP+ reductase activity
IBC08_RS07780	COG1126	abc transporter atp-binding protein
IBC08_RS07790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IBC08_RS07805	COG1882	Formate acetyltransferase
IBC08_RS07835	COG0390	transport system, permease component
IBC08_RS07840	COG4619	ABC transporter
IBC08_RS07845	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IBC08_RS07860	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IBC08_RS07920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IBC08_RS07925	COG2274	protein secretion by the type I secretion system
IBC08_RS07930	COG1132	(ABC) transporter
IBC08_RS07935	COG1132	(ABC) transporter
IBC08_RS07950	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IBC08_RS07955	COG4470	Protein conserved in bacteria
IBC08_RS07960	COG0737	Belongs to the 5'-nucleotidase family
IBC08_RS07975	COG0513	Belongs to the DEAD box helicase family
IBC08_RS07985	COG0768	penicillin binding
IBC08_RS08025	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IBC08_RS08040	COG4152	abc transporter atp-binding protein
IBC08_RS08045	COG1811	Na channel or pump
IBC08_RS08050	COG1074	ATP-dependent DNA helicase activity
IBC08_RS08055	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
IBC08_RS08090	COG0561	phosphatase activity
IBC08_RS08095	COG0252	asparaginase activity
IBC08_RS08100	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IBC08_RS08105	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IBC08_RS08115	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IBC08_RS08120	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IBC08_RS08125	COG0653	protein targeting
IBC08_RS08135	COG1482	cell wall glycoprotein biosynthetic process
IBC08_RS08140	COG1940	carbohydrate kinase activity
IBC08_RS08145	COG1263	PTS System
IBC08_RS08145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IBC08_RS08145	COG2190	(PTS) system
IBC08_RS08150	COG1621	beta-fructofuranosidase activity
IBC08_RS08170	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IBC08_RS08175	COG2131	deaminase
IBC08_RS08180	COG0006	proline dipeptidase activity
IBC08_RS08270	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IBC08_RS08270	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IBC08_RS08275	COG1193	negative regulation of DNA recombination
IBC08_RS08295	COG0681	Belongs to the peptidase S26 family
IBC08_RS08300	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IBC08_RS08310	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IBC08_RS08320	COG0456	acetyltransferase
IBC08_RS08325	COG1214	PFAM Peptidase M22, glycoprotease
IBC08_RS08345	COG0174	glutamine synthetase
IBC08_RS08350	COG0789	Transcriptional regulator
IBC08_RS08400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IBC08_RS08405	COG3481	metal-dependent phosphohydrolase, HD sub domain
IBC08_RS08435	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IBC08_RS08445	COG0084	hydrolase, TatD family'
IBC08_RS08455	COG3118	belongs to the thioredoxin family
IBC08_RS08520	COG0706	membrane insertase activity
IBC08_RS08585	COG0756	dUTP diphosphatase activity
IBC08_RS08595	COG0431	NADPH-dependent FMN reductase
IBC08_RS08595	COG1053	succinate dehydrogenase
IBC08_RS08595	COG3976	FMN-binding domain protein
IBC08_RS08620	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IBC08_RS08625	COG0457	Tetratricopeptide repeat
IBC08_RS08625	COG0705	Rhomboid family
IBC08_RS08630	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IBC08_RS08650	COG2226	methyltransferase
IBC08_RS08675	COG0425	Belongs to the sulfur carrier protein TusA family
IBC08_RS08680	COG2391	methyltransferase activity
IBC08_RS08685	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IBC08_RS08690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IBC08_RS08700	COG1363	Peptidase, m42
IBC08_RS08705	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IBC08_RS08715	COG1266	CAAX protease self-immunity
IBC08_RS08770	COG1459	type II secretion system
IBC08_RS08775	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IBC08_RS08810	COG0440	acetolactate synthase activity
IBC08_RS08815	COG0028	Belongs to the TPP enzyme family
IBC08_RS08820	COG0129	dihydroxy-acid dehydratase activity
IBC08_RS08825	COG1461	Dihydroxyacetone kinase
IBC08_RS08835	COG0534	Mate efflux family protein
IBC08_RS08855	COG1454	alcohol dehydrogenase
IBC08_RS08855	COG1012	belongs to the aldehyde dehydrogenase family
IBC08_RS08860	COG1012	belongs to the aldehyde dehydrogenase family
IBC08_RS08860	COG1454	alcohol dehydrogenase
IBC08_RS08870	COG1012	belongs to the aldehyde dehydrogenase family
IBC08_RS08870	COG1454	alcohol dehydrogenase
IBC08_RS08875	COG3590	peptidase
IBC08_RS08890	COG1609	Transcriptional regulator
IBC08_RS08895	COG2188	Transcriptional regulator
IBC08_RS08900	COG4475	Protein of unknown function (DUF436)
IBC08_RS08930	COG1301	dicarboxylic acid transport
IBC08_RS09000	COG0191	fructose-bisphosphate aldolase activity
IBC08_RS09065	COG0201	protein transport
IBC08_RS09225	COG1132	(ABC) transporter
IBC08_RS09255	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IBC08_RS09285	COG1328	CTP reductase activity
IBC08_RS09295	COG0602	queuosine metabolic process
IBC08_RS09305	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IBC08_RS09330	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IBC08_RS09340	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IBC08_RS09350	COG1002	Type II restriction enzyme, methylase subunits
IBC08_RS09380	COG0582	viral genome integration into host DNA
IBC08_RS09395	COG1597	lipid kinase activity
IBC08_RS09410	COG2261	transglycosylase associated protein
IBC08_RS09430	COG3237	CsbD-like
IBC08_RS09460	COG1511	domain protein
IBC08_RS09460	COG1511	domain protein
IBC08_RS09470	COG3759	membrane
IBC08_RS09490	COG0305	Participates in initiation and elongation during chromosome replication
IBC08_RS09510	COG0494	nUDIX hydrolase
IBC08_RS09525	COG0741	lytic transglycosylase activity
IBC08_RS09530	COG1388	LysM domain
IBC08_RS09530	COG3584	3D domain protein
IBC08_RS09535	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IBC08_RS09550	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IBC08_RS09590	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IBC08_RS09595	COG0488	(ABC) transporter
IBC08_RS09630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IBC08_RS09635	COG1475	DNA binding