locus-tag	class	description
B1761_RS00005	COG2217	Heavy metal translocating P-type atpase
B1761_RS00025	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B1761_RS00030	COG0626	cystathionine gamma-synthase activity
B1761_RS00035	COG1045	serine acetyltransferase
B1761_RS00055	COG3328	transposase activity
B1761_RS00060	COG4975	Glucose uptake
B1761_RS00085	COG3443	Belongs to the bacterial solute-binding protein 9 family
B1761_RS00085	COG0803	Belongs to the bacterial solute-binding protein 9 family
B1761_RS00105	COG3942	CHAP domain
B1761_RS00105	COG1705	Flagellar rod assembly protein muramidase FlgJ
B1761_RS00120	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B1761_RS00125	COG2824	Alkylphosphonate utilization operon protein PhnA
B1761_RS00130	COG0765	amino acid transport
B1761_RS00135	COG1126	abc transporter atp-binding protein
B1761_RS00140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1761_RS00150	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B1761_RS00165	COG1064	alcohol dehydrogenase
B1761_RS00170	COG1064	alcohol dehydrogenase
B1761_RS00180	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B1761_RS00180	COG0519	Catalyzes the synthesis of GMP from XMP
B1761_RS00185	COG2188	Transcriptional regulator
B1761_RS00195	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B1761_RS00205	COG1827	regulation of RNA biosynthetic process
B1761_RS00215	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B1761_RS00225	COG1940	carbohydrate kinase activity
B1761_RS00230	COG0758	DNA mediated transformation
B1761_RS00235	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B1761_RS00280	COG0481	GTPase activity
B1761_RS00290	COG1396	sequence-specific DNA binding
B1761_RS00300	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B1761_RS00305	COG0010	Belongs to the arginase family
B1761_RS00315	COG0028	Belongs to the TPP enzyme family
B1761_RS00320	COG3527	Alpha-acetolactate decarboxylase
B1761_RS00355	COG1230	cation diffusion facilitator family transporter
B1761_RS00365	COG1063	alcohol dehydrogenase
B1761_RS00400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B1761_RS00405	COG4607	ABC-type enterochelin transport system periplasmic component
B1761_RS00430	COG0534	Mate efflux family protein
B1761_RS00445	COG1293	RNA-binding protein homologous to eukaryotic snRNP
B1761_RS00480	COG0047	phosphoribosylformylglycinamidine synthase activity
B1761_RS00495	COG0167	dihydroorotate dehydrogenase activity
B1761_RS00505	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
B1761_RS00525	COG1337	RAMP superfamily
B1761_RS00530	COG1567	CRISPR-associated RAMP protein, Csm4 family
B1761_RS00545	COG0284	orotidine-5'-phosphate decarboxylase activity
B1761_RS00560	COG3104	oligopeptide transport
B1761_RS00565	COG0154	amidase activity
B1761_RS00570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1761_RS00575	COG0765	amino acid transport
B1761_RS00620	COG1115	amino acid carrier protein
B1761_RS00630	COG2873	o-acetylhomoserine
B1761_RS00665	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B1761_RS00670	COG0196	riboflavin kinase activity
B1761_RS00675	COG1393	Belongs to the ArsC family
B1761_RS00685	COG0483	inositol monophosphate 1-phosphatase activity
B1761_RS00690	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
B1761_RS00690	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B1761_RS00700	COG0573	inorganic phosphate transmembrane transporter activity
B1761_RS00705	COG0581	inorganic phosphate transmembrane transporter activity
B1761_RS00720	COG0704	Plays a role in the regulation of phosphate uptake
B1761_RS00735	COG0095	Lipoate-protein ligase
B1761_RS00750	COG0058	SHG alpha-glucan phosphorylase activity
B1761_RS00755	COG1640	4-alpha-glucanotransferase
B1761_RS00760	COG1609	Transcriptional regulator
B1761_RS00775	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B1761_RS00780	COG0805	protein transport
B1761_RS00785	COG0672	)-iron permease
B1761_RS00790	COG2837	iron assimilation
B1761_RS00795	COG2822	iron ion transport
B1761_RS00810	COG1523	belongs to the glycosyl hydrolase 13 family
B1761_RS00820	COG1523	belongs to the glycosyl hydrolase 13 family
B1761_RS00835	COG0508	dehydrogenase complex catalyzes the overall conversion of
B1761_RS00840	COG0022	dehydrogenase e1 component
B1761_RS00840	COG0508	dehydrogenase complex catalyzes the overall conversion of
B1761_RS00845	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B1761_RS00880	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B1761_RS00885	COG4667	esterase of the alpha-beta hydrolase superfamily
B1761_RS00920	COG0628	permease
B1761_RS00940	COG0561	phosphatase activity
B1761_RS00965	COG1216	Glycosyl transferase, family 2
B1761_RS00965	COG1442	glycosyl transferase family 8
B1761_RS00985	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B1761_RS00995	COG2963	transposase activity
B1761_RS01015	COG2244	polysaccharide biosynthetic process
B1761_RS01025	COG1216	Glycosyl transferase, family 2
B1761_RS01025	COG1442	glycosyl transferase family 8
B1761_RS01030	COG1442	glycosyl transferase family 8
B1761_RS01080	COG1316	TRANSCRIPTIONal
B1761_RS01105	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B1761_RS01115	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
B1761_RS01135	COG1573	uracil-dna glycosylase
B1761_RS01200	COG0681	Belongs to the peptidase S26 family
B1761_RS01210	COG0628	permease
B1761_RS01215	COG1051	belongs to the nudix hydrolase family
B1761_RS01220	COG2177	Part of the ABC transporter FtsEX involved in
B1761_RS01225	COG2884	Cell division ATP-binding protein ftsE
B1761_RS01230	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B1761_RS01235	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B1761_RS01270	COG2348	transferase activity, transferring amino-acyl groups
B1761_RS01280	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B1761_RS01285	COG5002	protein histidine kinase activity
B1761_RS01290	COG0745	RESPONSE REGULATOR receiver
B1761_RS01295	COG1126	abc transporter atp-binding protein
B1761_RS01300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1761_RS01305	COG0765	amino acid transport
B1761_RS01310	COG0765	amino acid transport
B1761_RS01335	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B1761_RS01390	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B1761_RS01395	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
B1761_RS01395	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
B1761_RS01405	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B1761_RS01410	COG1956	GAF domain-containing protein
B1761_RS01415	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B1761_RS01450	COG0335	large ribosomal subunit rRNA binding
B1761_RS01465	COG0038	chloride channel
B1761_RS01470	COG0716	FMN binding
B1761_RS01530	COG3328	transposase activity
B1761_RS01545	COG0469	pyruvate kinase activity
B1761_RS01595	COG0167	dihydroorotate dehydrogenase activity
B1761_RS01605	COG0776	regulation of translation
B1761_RS01615	COG2755	lipolytic protein G-D-S-L family
B1761_RS01620	COG1307	EDD domain protein, DegV family
B1761_RS01625	COG0497	DNA recombination
B1761_RS01630	COG1438	arginine binding
B1761_RS01635	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
B1761_RS01660	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B1761_RS01680	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B1761_RS01680	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
B1761_RS01685	COG0300	oxidoreductase activity
B1761_RS01700	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B1761_RS01705	COG0772	Belongs to the SEDS family
B1761_RS01720	COG0107	imidazoleglycerol-phosphate synthase activity
B1761_RS01730	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B1761_RS01740	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B1761_RS01790	COG0647	UMP catabolic process
B1761_RS01800	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B1761_RS01825	COG1088	dTDP-glucose 4,6-dehydratase activity
B1761_RS01835	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
B1761_RS01840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1761_RS01855	COG2384	SAM-dependent methyltransferase
B1761_RS01880	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B1761_RS01885	COG3442	glutamine amidotransferase
B1761_RS01890	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B1761_RS01890	COG0392	lysyltransferase activity
B1761_RS01905	COG0488	(ABC) transporter
B1761_RS01915	COG0513	Belongs to the DEAD box helicase family
B1761_RS01950	COG0372	Belongs to the citrate synthase family
B1761_RS01955	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B1761_RS01960	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B1761_RS01965	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B1761_RS01970	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B1761_RS01995	COG0346	lactoylglutathione lyase activity
B1761_RS02000	COG3764	Sortase (surface protein transpeptidase)
B1761_RS02020	COG0488	(ABC) transporter
B1761_RS02045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B1761_RS02050	COG1328	CTP reductase activity
B1761_RS02050	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B1761_RS02085	COG1196	nuclear chromosome segregation
B1761_RS02100	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B1761_RS02120	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B1761_RS02130	COG1011	Hydrolase
B1761_RS02135	COG1268	BioY protein
B1761_RS02145	COG0517	IMP dehydrogenase activity
B1761_RS02145	COG1125	glycine betaine transport
B1761_RS02160	COG2986	histidine ammonia-lyase
B1761_RS02170	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B1761_RS02175	COG1760	l-serine dehydratase
B1761_RS02180	COG2197	response regulator
B1761_RS02185	COG4585	Histidine kinase
B1761_RS02195	COG1131	(ABC) transporter
B1761_RS02210	COG0385	Bile acid
B1761_RS02225	COG1131	(ABC) transporter
B1761_RS02245	COG0577	efflux transmembrane transporter activity
B1761_RS02250	COG1136	(ABC) transporter
B1761_RS02255	COG2205	protein histidine kinase activity
B1761_RS02255	COG0784	Response regulator, receiver
B1761_RS02260	COG0745	RESPONSE REGULATOR receiver
B1761_RS02270	COG2233	PERMEase
B1761_RS02275	COG2233	PERMEase
B1761_RS02280	COG0534	Mate efflux family protein
B1761_RS02285	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B1761_RS02285	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B1761_RS02320	COG0531	amino acid
B1761_RS02330	COG2514	catechol 2,3-dioxygenase activity
B1761_RS02335	COG1959	2 iron, 2 sulfur cluster binding
B1761_RS02345	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B1761_RS02350	COG0778	Nitroreductase
B1761_RS02360	COG0656	L-ascorbic acid biosynthetic process
B1761_RS02405	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B1761_RS02425	COG1280	lysine exporter protein (LysE YggA)
B1761_RS02440	COG1442	glycosyl transferase family 8
B1761_RS02440	COG1216	Glycosyl transferase, family 2
B1761_RS02445	COG0577	efflux transmembrane transporter activity
B1761_RS02495	COG1396	sequence-specific DNA binding
B1761_RS02510	COG0419	ATPase involved in DNA repair
B1761_RS02515	COG0420	3'-5' exonuclease activity
B1761_RS02525	COG3250	beta-galactosidase activity
B1761_RS02530	COG2190	(PTS) system
B1761_RS02530	COG2211	Major facilitator Superfamily
B1761_RS02535	COG2017	converts alpha-aldose to the beta-anomer
B1761_RS02540	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B1761_RS02555	COG1609	Transcriptional regulator
B1761_RS02570	COG3064	Membrane
B1761_RS02575	COG3064	Membrane
B1761_RS02580	COG0488	(ABC) transporter
B1761_RS02585	COG1132	(ABC) transporter
B1761_RS02640	COG2197	response regulator
B1761_RS02645	COG4585	Histidine kinase
B1761_RS02660	COG0515	serine threonine protein kinase
B1761_RS02660	COG2815	serine threonine protein kinase
B1761_RS02670	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B1761_RS02670	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B1761_RS02680	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B1761_RS02695	COG0552	protein localization to endoplasmic reticulum
B1761_RS02700	COG0561	phosphatase activity
B1761_RS02705	COG0561	phosphatase activity
B1761_RS02710	COG1725	Transcriptional regulator
B1761_RS02715	COG1131	(ABC) transporter
B1761_RS02725	COG4608	Belongs to the ABC transporter superfamily
B1761_RS02730	COG0444	Belongs to the ABC transporter superfamily
B1761_RS02735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1761_RS02740	COG0601	transmembrane transport
B1761_RS02745	COG4166	transmembrane transport
B1761_RS02755	COG4166	transmembrane transport
B1761_RS02765	COG2801	Transposase and inactivated derivatives
B1761_RS02775	COG4608	Belongs to the ABC transporter superfamily
B1761_RS02780	COG4608	Belongs to the ABC transporter superfamily
B1761_RS02785	COG0084	hydrolase, TatD family'
B1761_RS02790	COG2223	nitrite transmembrane transporter activity
B1761_RS02800	COG0280	phosphate acetyltransferase
B1761_RS02805	COG0564	pseudouridine synthase activity
B1761_RS02815	COG2357	RelA SpoT domain protein
B1761_RS02830	COG1104	cysteine desulfurase activity
B1761_RS02845	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B1761_RS02850	COG2003	Belongs to the UPF0758 family
B1761_RS02895	COG1216	Glycosyl transferase, family 2
B1761_RS02895	COG1442	glycosyl transferase family 8
B1761_RS02910	COG0463	Glycosyl transferase, family 2
B1761_RS02915	COG1216	Glycosyl transferase, family 2
B1761_RS02920	COG1216	Glycosyl transferase, family 2
B1761_RS02930	COG1091	dTDP-4-dehydrorhamnose reductase activity
B1761_RS02940	COG0463	Glycosyl transferase, family 2
B1761_RS02945	COG2151	metal-sulfur cluster biosynthetic enzyme
B1761_RS02955	COG1970	mechanosensitive ion channel activity
B1761_RS02965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1761_RS02970	COG0436	Aminotransferase
B1761_RS02975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1761_RS02980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1761_RS02985	COG1051	belongs to the nudix hydrolase family
B1761_RS03005	COG0765	amino acid transport
B1761_RS03010	COG1126	abc transporter atp-binding protein
B1761_RS03070	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
B1761_RS03075	COG1518	maintenance of DNA repeat elements
B1761_RS03080	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
B1761_RS03085	COG0560	Phosphoserine phosphatase
B1761_RS03095	COG0187	DNA topoisomerase II activity
B1761_RS03105	COG1346	cytolysis
B1761_RS03110	COG1380	Effector of murein hydrolase LrgA
B1761_RS03120	COG1393	Belongs to the ArsC family
B1761_RS03130	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B1761_RS03145	COG1940	carbohydrate kinase activity
B1761_RS03170	COG1177	transmembrane transport
B1761_RS03175	COG1176	ABC-type spermidine putrescine transport system, permease component I
B1761_RS03215	COG0531	amino acid
B1761_RS03220	COG0285	dihydrofolate synthase activity
B1761_RS03225	COG1837	Belongs to the UPF0109 family
B1761_RS03235	COG3615	Tellurite resistance protein tehB
B1761_RS03235	COG0500	methyltransferase
B1761_RS03240	COG0708	Exodeoxyribonuclease III
B1761_RS03255	COG1597	lipid kinase activity
B1761_RS03265	COG4708	membrane
B1761_RS03275	COG0024	Methionine aminopeptidase
B1761_RS03280	COG4109	DRTGG domain
B1761_RS03290	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B1761_RS03295	COG2333	competence protein COMEC
B1761_RS03295	COG0658	competence protein
B1761_RS03300	COG1555	photosystem II stabilization
B1761_RS03300	COG1596	polysaccharide export
B1761_RS03315	COG0726	polysaccharide deacetylase
B1761_RS03320	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
B1761_RS03330	COG0513	Belongs to the DEAD box helicase family
B1761_RS03350	COG1396	sequence-specific DNA binding
B1761_RS03355	COG2211	Major facilitator Superfamily
B1761_RS03370	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B1761_RS03385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1761_RS03390	COG1126	abc transporter atp-binding protein
B1761_RS03395	COG0765	amino acid transport
B1761_RS03400	COG0765	amino acid transport
B1761_RS03415	COG2217	Heavy metal translocating P-type atpase
B1761_RS03425	COG0159	tryptophan synthase activity
B1761_RS03435	COG0135	phosphoribosylanthranilate isomerase activity
B1761_RS03450	COG0512	Glutamine amidotransferase of anthranilate synthase
B1761_RS03455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B1761_RS03460	COG1605	Chorismate mutase
B1761_RS03460	COG0287	Prephenate dehydrogenase
B1761_RS03470	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B1761_RS03495	COG2176	DNA-directed DNA polymerase activity
B1761_RS03505	COG2151	metal-sulfur cluster biosynthetic enzyme
B1761_RS03515	COG2081	HI0933 family
B1761_RS03540	COG1131	(ABC) transporter
B1761_RS03545	COG0537	adenosine 5'-monophosphoramidase activity
B1761_RS03575	COG2226	methyltransferase
B1761_RS03580	COG0799	negative regulation of ribosome biogenesis
B1761_RS03585	COG1713	HD superfamily hydrolase involved in NAD metabolism
B1761_RS03590	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B1761_RS03595	COG1534	Rna-binding protein
B1761_RS03600	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B1761_RS03605	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
B1761_RS03660	COG1335	isochorismatase
B1761_RS03670	COG0436	Aminotransferase
B1761_RS03675	COG0589	response to stress
B1761_RS03690	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B1761_RS03700	COG1253	flavin adenine dinucleotide binding
B1761_RS03705	COG1119	ATPase activity
B1761_RS03710	COG0025	NhaP-type Na H and K H
B1761_RS03720	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
B1761_RS03725	COG1242	4 iron, 4 sulfur cluster binding
B1761_RS03730	COG3480	Lon protease (S16) C-terminal proteolytic domain
B1761_RS03735	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B1761_RS03740	COG0742	ribosomal rna small subunit methyltransferase
B1761_RS03745	COG0492	ferredoxin-NADP+ reductase activity
B1761_RS03755	COG1126	abc transporter atp-binding protein
B1761_RS03765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1761_RS03780	COG1882	Formate acetyltransferase
B1761_RS03810	COG0390	transport system, permease component
B1761_RS03815	COG4619	ABC transporter
B1761_RS03820	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B1761_RS03835	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B1761_RS03915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B1761_RS03920	COG2274	protein secretion by the type I secretion system
B1761_RS03930	COG1132	(ABC) transporter
B1761_RS03935	COG1132	(ABC) transporter
B1761_RS03950	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B1761_RS03955	COG4470	Protein conserved in bacteria
B1761_RS03960	COG0737	Belongs to the 5'-nucleotidase family
B1761_RS03965	COG0513	Belongs to the DEAD box helicase family
B1761_RS03975	COG0768	penicillin binding
B1761_RS04005	COG3152	Membrane
B1761_RS04010	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B1761_RS04025	COG4152	abc transporter atp-binding protein
B1761_RS04030	COG1811	Na channel or pump
B1761_RS04070	COG0561	phosphatase activity
B1761_RS04075	COG0252	asparaginase activity
B1761_RS04080	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B1761_RS04095	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B1761_RS04100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B1761_RS04115	COG1482	cell wall glycoprotein biosynthetic process
B1761_RS04120	COG1940	carbohydrate kinase activity
B1761_RS04125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B1761_RS04125	COG1263	PTS System
B1761_RS04125	COG2190	(PTS) system
B1761_RS04130	COG1621	beta-fructofuranosidase activity
B1761_RS04135	COG1609	Transcriptional regulator
B1761_RS04155	COG2131	deaminase
B1761_RS04160	COG0006	proline dipeptidase activity
B1761_RS04175	COG1131	(ABC) transporter
B1761_RS04250	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B1761_RS04250	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B1761_RS04255	COG1193	negative regulation of DNA recombination
B1761_RS04275	COG0681	Belongs to the peptidase S26 family
B1761_RS04280	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B1761_RS04290	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
B1761_RS04300	COG0456	acetyltransferase
B1761_RS04305	COG1214	PFAM Peptidase M22, glycoprotease
B1761_RS04325	COG0174	glutamine synthetase
B1761_RS04330	COG0789	Transcriptional regulator
B1761_RS04385	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B1761_RS04430	COG0084	hydrolase, TatD family'
B1761_RS04435	COG1832	CoA-binding protein
B1761_RS04440	COG3118	belongs to the thioredoxin family
B1761_RS04505	COG0706	membrane insertase activity
B1761_RS04530	COG4166	transmembrane transport
B1761_RS04535	COG4166	transmembrane transport
B1761_RS04570	COG0756	dUTP diphosphatase activity
B1761_RS04605	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B1761_RS04615	COG0457	Tetratricopeptide repeat
B1761_RS04615	COG0705	Rhomboid family
B1761_RS04620	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B1761_RS04645	COG2226	methyltransferase
B1761_RS04675	COG0425	Belongs to the sulfur carrier protein TusA family
B1761_RS04680	COG2391	methyltransferase activity
B1761_RS04685	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B1761_RS04690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B1761_RS04700	COG1363	Peptidase, m42
B1761_RS04705	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B1761_RS04710	COG1266	CAAX protease self-immunity
B1761_RS04770	COG1459	type II secretion system
B1761_RS04775	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B1761_RS04810	COG0440	acetolactate synthase activity
B1761_RS04815	COG0028	Belongs to the TPP enzyme family
B1761_RS04825	COG1461	Dihydroxyacetone kinase
B1761_RS04835	COG0534	Mate efflux family protein
B1761_RS04855	COG1454	alcohol dehydrogenase
B1761_RS04855	COG1012	belongs to the aldehyde dehydrogenase family
B1761_RS04860	COG1012	belongs to the aldehyde dehydrogenase family
B1761_RS04860	COG1454	alcohol dehydrogenase
B1761_RS04865	COG1012	belongs to the aldehyde dehydrogenase family
B1761_RS04865	COG1454	alcohol dehydrogenase
B1761_RS04870	COG1454	alcohol dehydrogenase
B1761_RS04870	COG1012	belongs to the aldehyde dehydrogenase family
B1761_RS04875	COG3590	peptidase
B1761_RS04890	COG1609	Transcriptional regulator
B1761_RS04895	COG2188	Transcriptional regulator
B1761_RS04900	COG4475	Protein of unknown function (DUF436)
B1761_RS04925	COG1301	dicarboxylic acid transport
B1761_RS04995	COG0191	fructose-bisphosphate aldolase activity
B1761_RS05065	COG0201	protein transport
B1761_RS05205	COG1396	sequence-specific DNA binding
B1761_RS05215	COG1132	(ABC) transporter
B1761_RS05255	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B1761_RS05295	COG0602	queuosine metabolic process
B1761_RS05305	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B1761_RS05335	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B1761_RS05345	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B1761_RS05375	COG2261	transglycosylase associated protein
B1761_RS05395	COG3237	CsbD-like
B1761_RS05425	COG1511	domain protein
B1761_RS05425	COG1511	domain protein
B1761_RS05435	COG3759	membrane
B1761_RS05450	COG0305	Participates in initiation and elongation during chromosome replication
B1761_RS05470	COG0494	nUDIX hydrolase
B1761_RS05485	COG0741	lytic transglycosylase activity
B1761_RS05490	COG1388	LysM domain
B1761_RS05490	COG3584	3D domain protein
B1761_RS05495	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B1761_RS05510	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B1761_RS05520	COG0612	Peptidase, M16
B1761_RS05550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B1761_RS05555	COG0488	(ABC) transporter
B1761_RS05590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1761_RS05595	COG1475	DNA binding
B1761_RS05605	COG0592	DNA-directed DNA polymerase activity
B1761_RS05615	COG0012	GTP binding
B1761_RS05625	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B1761_RS05630	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B1761_RS05660	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B1761_RS05790	COG3942	CHAP domain
B1761_RS05805	COG0436	Aminotransferase
B1761_RS05820	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B1761_RS05830	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B1761_RS05845	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B1761_RS05860	COG1388	LysM domain
B1761_RS05860	COG3942	CHAP domain
B1761_RS05865	COG0151	Belongs to the GarS family
B1761_RS05870	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B1761_RS05890	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B1761_RS05940	COG4550	Control of competence regulator ComK, YlbF/YmcA
B1761_RS05980	COG2818	Glycosylase
B1761_RS05990	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B1761_RS05995	COG1393	Belongs to the ArsC family
B1761_RS06085	COG2309	aminopeptidase activity
B1761_RS06100	COG0431	NADPH-dependent FMN reductase
B1761_RS06140	COG4463	regulation of RNA biosynthetic process
B1761_RS06145	COG0542	response to heat
B1761_RS06150	COG1686	Belongs to the peptidase S11 family
B1761_RS06160	COG1686	Belongs to the peptidase S11 family
B1761_RS06175	COG1045	serine acetyltransferase
B1761_RS06185	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
B1761_RS06200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B1761_RS06230	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B1761_RS06290	COG1705	Flagellar rod assembly protein muramidase FlgJ
B1761_RS06290	COG3942	CHAP domain
B1761_RS06305	COG3830	Belongs to the UPF0237 family
B1761_RS06320	COG1876	peptidase activity
B1761_RS06355	COG0351	phosphomethylpyrimidine kinase
B1761_RS06455	COG4166	transmembrane transport
B1761_RS06475	COG1473	amidohydrolase
B1761_RS06480	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B1761_RS06500	COG0668	transmembrane transport
B1761_RS06515	COG0504	CTP synthase activity
B1761_RS06525	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
B1761_RS06535	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B1761_RS06545	COG0737	Belongs to the 5'-nucleotidase family
B1761_RS06585	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B1761_RS06620	COG1126	abc transporter atp-binding protein
B1761_RS06625	COG0765	amino acid transport
B1761_RS06630	COG1968	undecaprenyl-diphosphatase activity
B1761_RS06645	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B1761_RS06655	COG0719	Fe-S assembly protein
B1761_RS06660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B1761_RS06670	COG0719	Fe-S assembly protein
B1761_RS06680	COG0601	transmembrane transport
B1761_RS06710	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B1761_RS06725	COG1121	(ABC) transporter
B1761_RS06730	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B1761_RS06740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B1761_RS06740	COG2190	(PTS) system
B1761_RS06740	COG1263	PTS System
B1761_RS06750	COG1263	PTS System
B1761_RS06750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B1761_RS06750	COG2190	(PTS) system
B1761_RS06755	COG1263	PTS System
B1761_RS06755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B1761_RS06755	COG2190	(PTS) system
B1761_RS06785	COG4589	Belongs to the CDS family
B1761_RS06800	COG4120	Belongs to the binding-protein-dependent transport system permease family
B1761_RS06805	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B1761_RS06805	COG1116	anion transmembrane transporter activity
B1761_RS06840	COG0564	pseudouridine synthase activity
B1761_RS06845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B1761_RS06875	COG1349	DNA-binding transcription factor activity
B1761_RS06905	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B1761_RS06920	COG3579	cysteine-type endopeptidase activity
B1761_RS06930	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B1761_RS06955	COG0116	Belongs to the methyltransferase superfamily
B1761_RS06965	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B1761_RS06985	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B1761_RS07010	COG1254	Belongs to the acylphosphatase family
B1761_RS07015	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B1761_RS07060	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B1761_RS07080	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B1761_RS07085	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B1761_RS07090	COG1187	pseudouridine synthase activity
B1761_RS07100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B1761_RS07105	COG0569	domain protein
B1761_RS07115	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
B1761_RS07120	COG0671	phosphoesterase, PA-phosphatase related
B1761_RS07140	COG2274	protein secretion by the type I secretion system
B1761_RS07145	COG2274	protein secretion by the type I secretion system
B1761_RS07150	COG2274	protein secretion by the type I secretion system
B1761_RS07155	COG2274	protein secretion by the type I secretion system
B1761_RS07205	COG0829	nickel cation binding
B1761_RS07210	COG0310	cobalt ion transport
B1761_RS07220	COG1122	ATPase activity
B1761_RS07225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1761_RS07230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B1761_RS07250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1761_RS07255	COG1464	Belongs to the NlpA lipoprotein family
B1761_RS07265	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B1761_RS07290	COG1122	ATPase activity
B1761_RS07300	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B1761_RS07315	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B1761_RS07330	COG0745	RESPONSE REGULATOR receiver
B1761_RS07335	COG5002	protein histidine kinase activity
B1761_RS07350	COG1484	DNA-dependent DNA replication
B1761_RS07390	COG3716	PTS system mannose fructose sorbose family IID component
B1761_RS07395	COG3715	PTS system
B1761_RS07405	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
B1761_RS07410	COG0561	phosphatase activity
B1761_RS07415	COG2252	PERMEase
B1761_RS07420	COG0802	atpase or kinase
B1761_RS07425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B1761_RS07430	COG1316	TRANSCRIPTIONal
B1761_RS07440	COG0195	Participates in both transcription termination and antitermination
B1761_RS07445	COG2740	Nucleic-acid-binding protein implicated in transcription termination
B1761_RS07465	COG1611	Belongs to the LOG family
B1761_RS07485	COG2244	polysaccharide biosynthetic process
B1761_RS07490	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B1761_RS07495	COG0626	cystathionine gamma-synthase activity
B1761_RS07500	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B1761_RS07530	COG4471	UPF0298 protein
B1761_RS07540	COG0559	Belongs to the binding-protein-dependent transport system permease family
B1761_RS07570	COG1739	Uncharacterized protein family UPF0029
B1761_RS07575	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
B1761_RS07580	COG1040	competence protein
B1761_RS07670	COG0527	aspartate kinase activity
B1761_RS07675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B1761_RS07680	COG1024	Enoyl-CoA hydratase
B1761_RS07685	COG1846	Transcriptional regulator
B1761_RS07705	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B1761_RS07710	COG1028	Short-chain dehydrogenase reductase Sdr
B1761_RS07715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B1761_RS07730	COG0439	Biotin carboxylase
B1761_RS07765	COG0076	glutamate decarboxylase activity
B1761_RS07770	COG0531	amino acid
B1761_RS07815	COG2801	Transposase and inactivated derivatives
B1761_RS07820	COG2963	transposase activity
B1761_RS07835	COG1349	DNA-binding transcription factor activity
B1761_RS07840	COG1105	Belongs to the carbohydrate kinase PfkB family
B1761_RS07845	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B1761_RS07845	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B1761_RS07845	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B1761_RS07850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B1761_RS07855	COG0285	dihydrofolate synthase activity
B1761_RS07865	COG1104	cysteine desulfurase activity
B1761_RS07925	COG0488	(ABC) transporter
B1761_RS07945	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B1761_RS07950	COG0242	peptide deformylase activity
B1761_RS08010	COG1702	phosphate starvation-inducible protein PhoH
B1761_RS08030	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B1761_RS08030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B1761_RS08055	COG4122	O-methyltransferase activity
B1761_RS08060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B1761_RS08090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B1761_RS08095	COG0436	Aminotransferase
B1761_RS08110	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B1761_RS08115	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B1761_RS08120	COG0726	polysaccharide deacetylase
B1761_RS08135	COG2962	Rard protein
B1761_RS08175	COG0356	it plays a direct role in the translocation of protons across the membrane
B1761_RS08210	COG0772	Belongs to the SEDS family
B1761_RS08230	COG0470	DNA polymerase III
B1761_RS08235	COG1774	PSP1 C-terminal conserved region
B1761_RS08240	COG4467	Involved in initiation control of chromosome replication
B1761_RS08250	COG0004	ammonium transporteR
B1761_RS08255	COG0347	Belongs to the P(II) protein family
B1761_RS08260	COG1388	LysM domain
B1761_RS08260	COG1705	Flagellar rod assembly protein muramidase FlgJ
B1761_RS08305	COG1113	amino acid transport
B1761_RS08315	COG2190	(PTS) system
B1761_RS08315	COG1263	PTS System
B1761_RS08315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B1761_RS08320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B1761_RS08320	COG1263	PTS System
B1761_RS08320	COG2190	(PTS) system
B1761_RS08360	COG0583	DNA-binding transcription factor activity
B1761_RS08370	COG0564	pseudouridine synthase activity
B1761_RS08390	COG0505	Belongs to the CarA family
B1761_RS08430	COG0577	efflux transmembrane transporter activity
B1761_RS08445	COG3328	transposase activity
B1761_RS08475	COG3279	Response regulator of the LytR AlgR family
B1761_RS08485	COG1131	(ABC) transporter
B1761_RS08520	COG1187	pseudouridine synthase activity
B1761_RS08525	COG1473	amidohydrolase
B1761_RS08530	COG0686	Belongs to the AlaDH PNT family
B1761_RS08535	COG0686	Belongs to the AlaDH PNT family
B1761_RS08540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B1761_RS08605	COG0438	transferase activity, transferring glycosyl groups
B1761_RS08640	COG1272	protein, Hemolysin III
B1761_RS08655	COG3425	synthase
B1761_RS08665	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B1761_RS08680	COG0833	amino acid
B1761_RS08685	COG2040	homocysteine
B1761_RS08705	COG0187	DNA topoisomerase II activity
B1761_RS08715	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B1761_RS08735	COG0539	negative regulation of cytoplasmic translation
B1761_RS08780	COG0494	nUDIX hydrolase
B1761_RS08785	COG0542	response to heat
B1761_RS08790	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B1761_RS08795	COG4703	Protein of unknown function (DUF1797)
B1761_RS08800	COG0765	amino acid transport
B1761_RS08850	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B1761_RS08855	COG0768	penicillin binding
B1761_RS08860	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B1761_RS08875	COG3711	transcriptional antiterminator
B1761_RS08885	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B1761_RS08890	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B1761_RS08895	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B1761_RS08900	COG0237	dephospho-CoA kinase activity
B1761_RS08905	COG2814	Major facilitator Superfamily
B1761_RS08920	COG0557	exoribonuclease II activity
B1761_RS08935	COG1185	polyribonucleotide nucleotidyltransferase activity
B1761_RS08940	COG0006	proline dipeptidase activity
B1761_RS08945	COG1609	Transcriptional regulator
B1761_RS08980	COG1368	sulfuric ester hydrolase activity
B1761_RS08985	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B1761_RS09010	COG0287	Prephenate dehydrogenase
B1761_RS09035	COG0077	Prephenate dehydratase
B1761_RS09100	COG1518	maintenance of DNA repeat elements
B1761_RS09105	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
B1761_RS09115	COG3689	TIGRFAM TIGR03943 family protein
B1761_RS09120	COG0701	Predicted permease
B1761_RS09125	COG2183	response to ionizing radiation
B1761_RS09170	COG0826	peptidase U32
B1761_RS09180	COG1268	BioY protein
B1761_RS09190	COG4443	Transcriptional Coactivator p15 (PC4)
B1761_RS09195	COG1914	H( )-stimulated, divalent metal cation uptake system
B1761_RS09230	COG1388	LysM domain
B1761_RS09230	COG1705	Flagellar rod assembly protein muramidase FlgJ
B1761_RS09250	COG0406	alpha-ribazole phosphatase activity
B1761_RS09255	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B1761_RS09285	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B1761_RS09295	COG0732	type I restriction modification DNA specificity domain
B1761_RS09315	COG1704	LemA family
B1761_RS09320	COG0501	Belongs to the peptidase M48B family
B1761_RS09345	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B1761_RS09360	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B1761_RS09365	COG0783	Belongs to the Dps family
B1761_RS09370	COG0735	belongs to the Fur family
B1761_RS09375	COG4483	Protein conserved in bacteria
B1761_RS09380	COG1940	carbohydrate kinase activity
B1761_RS09385	COG1217	gtp-binding protein TYPA
B1761_RS09410	COG0849	cell division
B1761_RS09420	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B1761_RS09445	COG3599	regulation of cell shape
B1761_RS09475	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B1761_RS09480	COG0625	glutathione transferase activity
B1761_RS09485	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B1761_RS09500	COG2890	protein-(glutamine-N5) methyltransferase activity
B1761_RS09530	COG1132	(ABC) transporter
B1761_RS09545	COG1696	Membrane protein involved in D-alanine export
B1761_RS09555	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
B1761_RS09585	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B1761_RS09590	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B1761_RS09655	COG1396	sequence-specific DNA binding
B1761_RS09660	COG0582	viral genome integration into host DNA
B1761_RS09680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B1761_RS09685	COG4684	Psort location CytoplasmicMembrane, score
B1761_RS09690	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B1761_RS09705	COG0745	RESPONSE REGULATOR receiver
B1761_RS09720	COG5002	protein histidine kinase activity
B1761_RS09745	COG2813	Specifically methylates the guanine in position
B1761_RS09760	COG0295	cytidine deaminase activity
B1761_RS09765	COG1744	ABC transporter substrate-binding protein PnrA-like
B1761_RS09770	COG3845	ABC transporter
B1761_RS09775	COG4603	Belongs to the binding-protein-dependent transport system permease family
B1761_RS09780	COG1079	Belongs to the binding-protein-dependent transport system permease family
B1761_RS09790	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B1761_RS09790	COG1199	ATP-dependent helicase activity
B1761_RS09800	COG0436	Aminotransferase
B1761_RS09820	COG0251	oxidation-reduction process
B1761_RS09830	COG0720	synthase
B1761_RS09895	COG1278	Cold shock
B1761_RS09910	COG3328	transposase activity