locus-tag	class	description
T303_RS00010	COG0706	membrane insertase activity
T303_RS00075	COG0756	dUTP diphosphatase activity
T303_RS00110	COG1210	Utp--glucose-1-phosphate uridylyltransferase
T303_RS00115	COG0457	Tetratricopeptide repeat
T303_RS00115	COG0705	Rhomboid family
T303_RS00120	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
T303_RS00140	COG2226	methyltransferase
T303_RS00165	COG0425	Belongs to the sulfur carrier protein TusA family
T303_RS00170	COG2391	methyltransferase activity
T303_RS00175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
T303_RS00180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
T303_RS00190	COG1363	Peptidase, m42
T303_RS00195	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
T303_RS00200	COG1266	CAAX protease self-immunity
T303_RS00260	COG1459	type II secretion system
T303_RS00265	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
T303_RS00300	COG0440	acetolactate synthase activity
T303_RS00305	COG0028	Belongs to the TPP enzyme family
T303_RS00310	COG0129	dihydroxy-acid dehydratase activity
T303_RS00315	COG1461	Dihydroxyacetone kinase
T303_RS00325	COG0534	Mate efflux family protein
T303_RS00350	COG1012	belongs to the aldehyde dehydrogenase family
T303_RS00350	COG1454	alcohol dehydrogenase
T303_RS00355	COG1012	belongs to the aldehyde dehydrogenase family
T303_RS00355	COG1454	alcohol dehydrogenase
T303_RS00360	COG1454	alcohol dehydrogenase
T303_RS00360	COG1012	belongs to the aldehyde dehydrogenase family
T303_RS00365	COG3590	peptidase
T303_RS00370	COG0366	Alpha amylase catalytic
T303_RS00375	COG0366	Alpha amylase catalytic
T303_RS00380	COG0366	Alpha amylase catalytic
T303_RS00390	COG1609	Transcriptional regulator
T303_RS00395	COG2188	Transcriptional regulator
T303_RS00400	COG4475	Protein of unknown function (DUF436)
T303_RS00435	COG0640	Transcriptional regulator
T303_RS00440	COG2217	Heavy metal translocating P-type atpase
T303_RS00470	COG3328	transposase activity
T303_RS00475	COG0582	viral genome integration into host DNA
T303_RS00480	COG0191	fructose-bisphosphate aldolase activity
T303_RS00540	COG0201	protein transport
T303_RS00685	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
T303_RS00690	COG3328	transposase activity
T303_RS00700	COG1132	(ABC) transporter
T303_RS00705	COG1396	sequence-specific DNA binding
T303_RS00715	COG1132	(ABC) transporter
T303_RS00750	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
T303_RS00790	COG0602	queuosine metabolic process
T303_RS00800	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
T303_RS00830	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
T303_RS00840	COG0267	Belongs to the bacterial ribosomal protein bL33 family
T303_RS00870	COG2261	transglycosylase associated protein
T303_RS00890	COG3237	CsbD-like
T303_RS00920	COG1511	domain protein
T303_RS00920	COG1511	domain protein
T303_RS00930	COG3759	membrane
T303_RS00945	COG0305	Participates in initiation and elongation during chromosome replication
T303_RS00965	COG0494	nUDIX hydrolase
T303_RS00980	COG0741	lytic transglycosylase activity
T303_RS00985	COG3584	3D domain protein
T303_RS00985	COG1388	LysM domain
T303_RS00990	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
T303_RS01005	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
T303_RS01015	COG0612	Peptidase, M16
T303_RS01045	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
T303_RS01050	COG0488	(ABC) transporter
T303_RS01085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
T303_RS01090	COG1475	DNA binding
T303_RS01100	COG0592	DNA-directed DNA polymerase activity
T303_RS01110	COG0012	GTP binding
T303_RS01120	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
T303_RS01125	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
T303_RS01155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
T303_RS01175	COG2801	Transposase and inactivated derivatives
T303_RS01295	COG3942	CHAP domain
T303_RS01310	COG0436	Aminotransferase
T303_RS01325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
T303_RS01335	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
T303_RS01350	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
T303_RS01370	COG2801	Transposase and inactivated derivatives
T303_RS01375	COG3942	CHAP domain
T303_RS01375	COG1388	LysM domain
T303_RS01380	COG0151	Belongs to the GarS family
T303_RS01385	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
T303_RS01405	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
T303_RS01420	COG4550	Control of competence regulator ComK, YlbF/YmcA
T303_RS01460	COG2818	Glycosylase
T303_RS01475	COG1393	Belongs to the ArsC family
T303_RS01565	COG2309	aminopeptidase activity
T303_RS01585	COG2801	Transposase and inactivated derivatives
T303_RS01605	COG1619	proteins homologs of microcin C7 resistance protein MccF
T303_RS01630	COG4463	regulation of RNA biosynthetic process
T303_RS01635	COG0542	response to heat
T303_RS01645	COG1686	Belongs to the peptidase S11 family
T303_RS01660	COG1045	serine acetyltransferase
T303_RS01670	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
T303_RS01685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
T303_RS01710	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
T303_RS01770	COG1705	Flagellar rod assembly protein muramidase FlgJ
T303_RS01770	COG3942	CHAP domain
T303_RS01785	COG3830	Belongs to the UPF0237 family
T303_RS01800	COG1876	peptidase activity
T303_RS01835	COG0351	phosphomethylpyrimidine kinase
T303_RS01840	COG4720	Psort location CytoplasmicMembrane, score
T303_RS01880	COG1473	amidohydrolase
T303_RS01885	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
T303_RS01900	COG0668	transmembrane transport
T303_RS01915	COG0504	CTP synthase activity
T303_RS01925	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
T303_RS01935	COG1385	rRNA (uridine-N3-)-methyltransferase activity
T303_RS01940	COG0737	Belongs to the 5'-nucleotidase family
T303_RS01975	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
T303_RS02005	COG1126	abc transporter atp-binding protein
T303_RS02010	COG0765	amino acid transport
T303_RS02025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
T303_RS02035	COG0719	Fe-S assembly protein
T303_RS02040	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
T303_RS02050	COG0719	Fe-S assembly protein
T303_RS02055	COG4166	transmembrane transport
T303_RS02060	COG0601	transmembrane transport
T303_RS02080	COG0444	Belongs to the ABC transporter superfamily
T303_RS02085	COG0444	Belongs to the ABC transporter superfamily
T303_RS02105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
T303_RS02120	COG1121	(ABC) transporter
T303_RS02125	COG1108	ABC-type Mn2 Zn2 transport systems permease components
T303_RS02135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
T303_RS02135	COG2190	(PTS) system
T303_RS02135	COG1263	PTS System
T303_RS02140	COG2190	(PTS) system
T303_RS02140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
T303_RS02140	COG1263	PTS System
T303_RS02145	COG1263	PTS System
T303_RS02145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
T303_RS02145	COG2190	(PTS) system
T303_RS02175	COG4589	Belongs to the CDS family
T303_RS02190	COG4120	Belongs to the binding-protein-dependent transport system permease family
T303_RS02195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
T303_RS02195	COG1116	anion transmembrane transporter activity
T303_RS02240	COG0564	pseudouridine synthase activity
T303_RS02245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
T303_RS02270	COG1349	DNA-binding transcription factor activity
T303_RS02295	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
T303_RS02310	COG3579	cysteine-type endopeptidase activity
T303_RS02315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
T303_RS02335	COG0116	Belongs to the methyltransferase superfamily
T303_RS02345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
T303_RS02365	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
T303_RS02390	COG1254	Belongs to the acylphosphatase family
T303_RS02395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
T303_RS02440	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
T303_RS02460	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
T303_RS02465	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
T303_RS02470	COG1187	pseudouridine synthase activity
T303_RS02480	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
T303_RS02485	COG0569	domain protein
T303_RS02495	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
T303_RS02500	COG0671	phosphoesterase, PA-phosphatase related
T303_RS02520	COG2274	protein secretion by the type I secretion system
T303_RS02525	COG2274	protein secretion by the type I secretion system
T303_RS02530	COG2274	protein secretion by the type I secretion system
T303_RS02580	COG0829	nickel cation binding
T303_RS02585	COG0310	cobalt ion transport
T303_RS02595	COG1122	ATPase activity
T303_RS02600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
T303_RS02605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
T303_RS02625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
T303_RS02630	COG1464	Belongs to the NlpA lipoprotein family
T303_RS02640	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
T303_RS02665	COG1122	ATPase activity
T303_RS02675	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
T303_RS02685	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
T303_RS02700	COG0745	RESPONSE REGULATOR receiver
T303_RS02705	COG5002	protein histidine kinase activity
T303_RS02720	COG1484	DNA-dependent DNA replication
T303_RS02735	COG2801	Transposase and inactivated derivatives
T303_RS02765	COG3716	PTS system mannose fructose sorbose family IID component
T303_RS02770	COG3715	PTS system
T303_RS02780	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
T303_RS02785	COG0561	phosphatase activity
T303_RS02790	COG2252	PERMEase
T303_RS02795	COG0802	atpase or kinase
T303_RS02800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
T303_RS02805	COG1316	TRANSCRIPTIONal
T303_RS02815	COG0195	Participates in both transcription termination and antitermination
T303_RS02820	COG2740	Nucleic-acid-binding protein implicated in transcription termination
T303_RS02840	COG1611	Belongs to the LOG family
T303_RS02860	COG2244	polysaccharide biosynthetic process
T303_RS02865	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
T303_RS02870	COG0626	cystathionine gamma-synthase activity
T303_RS02875	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
T303_RS02905	COG4471	UPF0298 protein
T303_RS02915	COG0559	Belongs to the binding-protein-dependent transport system permease family
T303_RS02935	COG0517	IMP dehydrogenase activity
T303_RS02950	COG1739	Uncharacterized protein family UPF0029
T303_RS02955	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
T303_RS02960	COG1040	competence protein
T303_RS03040	COG0527	aspartate kinase activity
T303_RS03045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
T303_RS03050	COG1024	Enoyl-CoA hydratase
T303_RS03055	COG1846	Transcriptional regulator
T303_RS03075	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
T303_RS03080	COG1028	Short-chain dehydrogenase reductase Sdr
T303_RS03085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
T303_RS03100	COG0439	Biotin carboxylase
T303_RS03135	COG1349	DNA-binding transcription factor activity
T303_RS03140	COG1105	Belongs to the carbohydrate kinase PfkB family
T303_RS03150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
T303_RS03155	COG0285	dihydrofolate synthase activity
T303_RS03165	COG1104	cysteine desulfurase activity
T303_RS03230	COG0488	(ABC) transporter
T303_RS03250	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
T303_RS03255	COG0242	peptide deformylase activity
T303_RS03315	COG1702	phosphate starvation-inducible protein PhoH
T303_RS03335	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
T303_RS03335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
T303_RS03360	COG4122	O-methyltransferase activity
T303_RS03365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
T303_RS03395	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
T303_RS03400	COG0436	Aminotransferase
T303_RS03415	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
T303_RS03420	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
T303_RS03425	COG0726	polysaccharide deacetylase
T303_RS03440	COG2962	Rard protein
T303_RS03480	COG0356	it plays a direct role in the translocation of protons across the membrane
T303_RS03515	COG0772	Belongs to the SEDS family
T303_RS03535	COG0470	DNA polymerase III
T303_RS03540	COG1774	PSP1 C-terminal conserved region
T303_RS03545	COG4467	Involved in initiation control of chromosome replication
T303_RS03555	COG0004	ammonium transporteR
T303_RS03560	COG0347	Belongs to the P(II) protein family
T303_RS03565	COG1705	Flagellar rod assembly protein muramidase FlgJ
T303_RS03565	COG1388	LysM domain
T303_RS03625	COG1113	amino acid transport
T303_RS03635	COG2190	(PTS) system
T303_RS03635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
T303_RS03635	COG1263	PTS System
T303_RS03650	COG2801	Transposase and inactivated derivatives
T303_RS03680	COG0583	DNA-binding transcription factor activity
T303_RS03690	COG0564	pseudouridine synthase activity
T303_RS03710	COG0505	Belongs to the CarA family
T303_RS03745	COG0577	efflux transmembrane transporter activity
T303_RS03750	COG0577	efflux transmembrane transporter activity
T303_RS03780	COG0577	efflux transmembrane transporter activity
T303_RS03830	COG3279	Response regulator of the LytR AlgR family
T303_RS03840	COG1131	(ABC) transporter
T303_RS03875	COG1187	pseudouridine synthase activity
T303_RS03880	COG1473	amidohydrolase
T303_RS03885	COG0686	Belongs to the AlaDH PNT family
T303_RS03890	COG0686	Belongs to the AlaDH PNT family
T303_RS03895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
T303_RS03960	COG0438	transferase activity, transferring glycosyl groups
T303_RS03990	COG1272	protein, Hemolysin III
T303_RS04005	COG3425	synthase
T303_RS04015	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
T303_RS04035	COG0833	amino acid
T303_RS04040	COG2040	homocysteine
T303_RS04060	COG0187	DNA topoisomerase II activity
T303_RS04070	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
T303_RS04090	COG0539	negative regulation of cytoplasmic translation
T303_RS04115	COG0673	inositol 2-dehydrogenase activity
T303_RS04130	COG0494	nUDIX hydrolase
T303_RS04135	COG0542	response to heat
T303_RS04140	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
T303_RS04145	COG4703	Protein of unknown function (DUF1797)
T303_RS04150	COG0765	amino acid transport
T303_RS04200	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
T303_RS04205	COG0768	penicillin binding
T303_RS04210	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
T303_RS04220	COG3711	transcriptional antiterminator
T303_RS04230	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
T303_RS04235	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
T303_RS04240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
T303_RS04245	COG0237	dephospho-CoA kinase activity
T303_RS04260	COG0557	exoribonuclease II activity
T303_RS04275	COG1185	polyribonucleotide nucleotidyltransferase activity
T303_RS04280	COG0006	proline dipeptidase activity
T303_RS04285	COG1609	Transcriptional regulator
T303_RS04315	COG1368	sulfuric ester hydrolase activity
T303_RS04320	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
T303_RS04345	COG0287	Prephenate dehydrogenase
T303_RS04370	COG0077	Prephenate dehydratase
T303_RS04430	COG2963	transposase activity
T303_RS04440	COG2801	Transposase and inactivated derivatives
T303_RS04495	COG1518	maintenance of DNA repeat elements
T303_RS04500	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
T303_RS04510	COG3689	TIGRFAM TIGR03943 family protein
T303_RS04515	COG0701	Predicted permease
T303_RS04520	COG2183	response to ionizing radiation
T303_RS04565	COG0826	peptidase U32
T303_RS04585	COG4443	Transcriptional Coactivator p15 (PC4)
T303_RS04595	COG1914	H( )-stimulated, divalent metal cation uptake system
T303_RS04605	COG0494	nUDIX hydrolase
T303_RS04615	COG3328	transposase activity
T303_RS04625	COG1388	LysM domain
T303_RS04625	COG1705	Flagellar rod assembly protein muramidase FlgJ
T303_RS04640	COG0406	alpha-ribazole phosphatase activity
T303_RS04645	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
T303_RS04680	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
T303_RS04735	COG1704	LemA family
T303_RS04765	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
T303_RS04775	COG0783	Belongs to the Dps family
T303_RS04780	COG0735	belongs to the Fur family
T303_RS04785	COG4483	Protein conserved in bacteria
T303_RS04790	COG1940	carbohydrate kinase activity
T303_RS04795	COG1217	gtp-binding protein TYPA
T303_RS04820	COG0849	cell division
T303_RS04830	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
T303_RS04850	COG3599	regulation of cell shape
T303_RS04885	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
T303_RS04890	COG0625	glutathione transferase activity
T303_RS04900	COG1435	thymidine kinase activity
T303_RS04910	COG2890	protein-(glutamine-N5) methyltransferase activity
T303_RS04940	COG1132	(ABC) transporter
T303_RS04955	COG1696	Membrane protein involved in D-alanine export
T303_RS04965	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
T303_RS04970	COG2801	Transposase and inactivated derivatives
T303_RS04975	COG2801	Transposase and inactivated derivatives
T303_RS04995	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
T303_RS05000	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
T303_RS05060	COG1396	sequence-specific DNA binding
T303_RS05065	COG0582	viral genome integration into host DNA
T303_RS05085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
T303_RS05090	COG4684	Psort location CytoplasmicMembrane, score
T303_RS05095	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
T303_RS05120	COG5002	protein histidine kinase activity
T303_RS05125	COG5002	protein histidine kinase activity
T303_RS05135	COG2801	Transposase and inactivated derivatives
T303_RS05155	COG0038	chloride channel
T303_RS05175	COG2801	Transposase and inactivated derivatives
T303_RS05195	COG2813	Specifically methylates the guanine in position
T303_RS05215	COG0295	cytidine deaminase activity
T303_RS05220	COG1744	ABC transporter substrate-binding protein PnrA-like
T303_RS05225	COG3845	ABC transporter
T303_RS05230	COG4603	Belongs to the binding-protein-dependent transport system permease family
T303_RS05235	COG1079	Belongs to the binding-protein-dependent transport system permease family
T303_RS05245	COG1199	ATP-dependent helicase activity
T303_RS05245	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
T303_RS05255	COG0436	Aminotransferase
T303_RS05285	COG0251	oxidation-reduction process
T303_RS05295	COG0720	synthase
T303_RS05340	COG1278	Cold shock
T303_RS05350	COG2801	Transposase and inactivated derivatives
T303_RS05360	COG3328	transposase activity
T303_RS05370	COG2217	Heavy metal translocating P-type atpase
T303_RS05385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
T303_RS05390	COG0626	cystathionine gamma-synthase activity
T303_RS05395	COG1045	serine acetyltransferase
T303_RS05415	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
T303_RS05420	COG4975	Glucose uptake
T303_RS05440	COG3443	Belongs to the bacterial solute-binding protein 9 family
T303_RS05440	COG0803	Belongs to the bacterial solute-binding protein 9 family
T303_RS05460	COG3942	CHAP domain
T303_RS05460	COG1705	Flagellar rod assembly protein muramidase FlgJ
T303_RS05475	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
T303_RS05480	COG2824	Alkylphosphonate utilization operon protein PhnA
T303_RS05485	COG0765	amino acid transport
T303_RS05490	COG1126	abc transporter atp-binding protein
T303_RS05495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
T303_RS05515	COG1064	alcohol dehydrogenase
T303_RS05530	COG2189	Belongs to the N(4) N(6)-methyltransferase family
T303_RS05535	COG0519	Catalyzes the synthesis of GMP from XMP
T303_RS05535	COG0518	GMP synthase (glutamine-hydrolyzing) activity
T303_RS05540	COG2188	Transcriptional regulator
T303_RS05550	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
T303_RS05560	COG1827	regulation of RNA biosynthetic process
T303_RS05570	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
T303_RS05580	COG1940	carbohydrate kinase activity
T303_RS05585	COG0758	DNA mediated transformation
T303_RS05590	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
T303_RS05640	COG1396	sequence-specific DNA binding
T303_RS05650	COG3328	transposase activity
T303_RS05655	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
T303_RS05670	COG0028	Belongs to the TPP enzyme family
T303_RS05675	COG3527	Alpha-acetolactate decarboxylase
T303_RS05710	COG1230	cation diffusion facilitator family transporter
T303_RS05720	COG1063	alcohol dehydrogenase
T303_RS05745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
T303_RS05765	COG1293	RNA-binding protein homologous to eukaryotic snRNP
T303_RS05775	COG0047	phosphoribosylformylglycinamidine synthase activity
T303_RS05785	COG0167	dihydroorotate dehydrogenase activity
T303_RS05790	COG1468	defense response to virus
T303_RS05790	COG1518	maintenance of DNA repeat elements
T303_RS05795	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
T303_RS05815	COG1337	RAMP superfamily
T303_RS05820	COG1567	CRISPR-associated RAMP protein, Csm4 family
T303_RS05835	COG0284	orotidine-5'-phosphate decarboxylase activity
T303_RS05850	COG3104	oligopeptide transport
T303_RS05865	COG0737	Belongs to the 5'-nucleotidase family
T303_RS05890	COG1115	amino acid carrier protein
T303_RS05900	COG2873	o-acetylhomoserine
T303_RS05930	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
T303_RS05935	COG0196	riboflavin kinase activity
T303_RS05940	COG1393	Belongs to the ArsC family
T303_RS05950	COG0483	inositol monophosphate 1-phosphatase activity
T303_RS05955	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
T303_RS05955	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
T303_RS05965	COG0573	inorganic phosphate transmembrane transporter activity
T303_RS05970	COG0581	inorganic phosphate transmembrane transporter activity
T303_RS05985	COG0704	Plays a role in the regulation of phosphate uptake
T303_RS06000	COG0095	Lipoate-protein ligase
T303_RS06015	COG0058	SHG alpha-glucan phosphorylase activity
T303_RS06020	COG1640	4-alpha-glucanotransferase
T303_RS06035	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
T303_RS06040	COG0805	protein transport
T303_RS06045	COG0672	)-iron permease
T303_RS06050	COG2837	iron assimilation
T303_RS06055	COG2822	iron ion transport
T303_RS06060	COG4607	ABC-type enterochelin transport system periplasmic component
T303_RS06065	COG4604	ABC transporter, ATP-binding protein
T303_RS06070	COG4605	iron ion homeostasis
T303_RS06075	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
T303_RS06085	COG1523	belongs to the glycosyl hydrolase 13 family
T303_RS06095	COG1523	belongs to the glycosyl hydrolase 13 family
T303_RS06120	COG0508	dehydrogenase complex catalyzes the overall conversion of
T303_RS06125	COG0508	dehydrogenase complex catalyzes the overall conversion of
T303_RS06125	COG0022	dehydrogenase e1 component
T303_RS06130	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
T303_RS06150	COG1518	maintenance of DNA repeat elements
T303_RS06165	COG1857	crispr-associated protein
T303_RS06200	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
T303_RS06210	COG4667	esterase of the alpha-beta hydrolase superfamily
T303_RS06240	COG0628	permease
T303_RS06265	COG0562	UDP-galactopyranose mutase
T303_RS06275	COG2244	polysaccharide biosynthetic process
T303_RS06280	COG1442	glycosyl transferase family 8
T303_RS06280	COG1216	Glycosyl transferase, family 2
T303_RS06295	COG1442	glycosyl transferase family 8
T303_RS06295	COG1216	Glycosyl transferase, family 2
T303_RS06345	COG1316	TRANSCRIPTIONal
T303_RS06370	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
T303_RS06380	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
T303_RS06400	COG1573	uracil-dna glycosylase
T303_RS06460	COG0681	Belongs to the peptidase S26 family
T303_RS06470	COG0628	permease
T303_RS06475	COG1051	belongs to the nudix hydrolase family
T303_RS06480	COG2177	Part of the ABC transporter FtsEX involved in
T303_RS06485	COG2884	Cell division ATP-binding protein ftsE
T303_RS06490	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
T303_RS06495	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
T303_RS06530	COG2348	transferase activity, transferring amino-acyl groups
T303_RS06540	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
T303_RS06545	COG5002	protein histidine kinase activity
T303_RS06550	COG0745	RESPONSE REGULATOR receiver
T303_RS06555	COG1126	abc transporter atp-binding protein
T303_RS06560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
T303_RS06565	COG0765	amino acid transport
T303_RS06570	COG0765	amino acid transport
T303_RS06595	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
T303_RS06605	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
T303_RS06610	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
T303_RS06610	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
T303_RS06620	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
T303_RS06625	COG1956	GAF domain-containing protein
T303_RS06630	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
T303_RS06645	COG0335	large ribosomal subunit rRNA binding
T303_RS06650	COG0038	chloride channel
T303_RS06660	COG0038	chloride channel
T303_RS06665	COG0716	FMN binding
T303_RS06740	COG0469	pyruvate kinase activity
T303_RS06790	COG0167	dihydroorotate dehydrogenase activity
T303_RS06800	COG0776	regulation of translation
T303_RS06810	COG2755	lipolytic protein G-D-S-L family
T303_RS06815	COG1307	EDD domain protein, DegV family
T303_RS06820	COG0497	DNA recombination
T303_RS06825	COG1438	arginine binding
T303_RS06830	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
T303_RS06855	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
T303_RS06875	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
T303_RS06875	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
T303_RS06880	COG0300	oxidoreductase activity
T303_RS06895	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
T303_RS06905	COG0772	Belongs to the SEDS family
T303_RS06920	COG0107	imidazoleglycerol-phosphate synthase activity
T303_RS06930	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
T303_RS06940	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
T303_RS06995	COG0647	UMP catabolic process
T303_RS07005	COG0635	Involved in the biosynthesis of porphyrin-containing compound
T303_RS07035	COG1088	dTDP-glucose 4,6-dehydratase activity
T303_RS07045	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
T303_RS07050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
T303_RS07065	COG2384	SAM-dependent methyltransferase
T303_RS07090	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
T303_RS07095	COG3442	glutamine amidotransferase
T303_RS07100	COG0392	lysyltransferase activity
T303_RS07100	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
T303_RS07115	COG0488	(ABC) transporter
T303_RS07125	COG0513	Belongs to the DEAD box helicase family
T303_RS07160	COG0372	Belongs to the citrate synthase family
T303_RS07165	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
T303_RS07170	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
T303_RS07175	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
T303_RS07180	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
T303_RS07210	COG3764	Sortase (surface protein transpeptidase)
T303_RS07230	COG0488	(ABC) transporter
T303_RS07260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
T303_RS07265	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
T303_RS07265	COG1328	CTP reductase activity
T303_RS07300	COG1196	nuclear chromosome segregation
T303_RS07315	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
T303_RS07335	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
T303_RS07345	COG1011	Hydrolase
T303_RS07350	COG1760	l-serine dehydratase
T303_RS07375	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
T303_RS07385	COG2197	response regulator
T303_RS07390	COG4585	Histidine kinase
T303_RS07400	COG1131	(ABC) transporter
T303_RS07435	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
T303_RS07450	COG1131	(ABC) transporter
T303_RS07470	COG0577	efflux transmembrane transporter activity
T303_RS07475	COG1136	(ABC) transporter
T303_RS07480	COG0784	Response regulator, receiver
T303_RS07480	COG5002	protein histidine kinase activity
T303_RS07480	COG2198	Histidine kinase
T303_RS07485	COG0745	RESPONSE REGULATOR receiver
T303_RS07495	COG2233	PERMEase
T303_RS07500	COG2233	PERMEase
T303_RS07505	COG0534	Mate efflux family protein
T303_RS07510	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
T303_RS07510	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
T303_RS07520	COG1482	cell wall glycoprotein biosynthetic process
T303_RS07525	COG1482	cell wall glycoprotein biosynthetic process
T303_RS07535	COG0531	amino acid
T303_RS07545	COG2514	catechol 2,3-dioxygenase activity
T303_RS07550	COG1959	2 iron, 2 sulfur cluster binding
T303_RS07560	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
T303_RS07565	COG0778	Nitroreductase
T303_RS07575	COG0656	L-ascorbic acid biosynthetic process
T303_RS07580	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
T303_RS07620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
T303_RS07645	COG1280	lysine exporter protein (LysE YggA)
T303_RS07655	COG1216	Glycosyl transferase, family 2
T303_RS07655	COG1442	glycosyl transferase family 8
T303_RS07660	COG0577	efflux transmembrane transporter activity
T303_RS07705	COG1396	sequence-specific DNA binding
T303_RS07710	COG2801	Transposase and inactivated derivatives
T303_RS07725	COG0419	ATPase involved in DNA repair
T303_RS07730	COG0420	3'-5' exonuclease activity
T303_RS07735	COG3250	beta-galactosidase activity
T303_RS07740	COG2211	Major facilitator Superfamily
T303_RS07740	COG2190	(PTS) system
T303_RS07745	COG2017	converts alpha-aldose to the beta-anomer
T303_RS07750	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
T303_RS07765	COG1609	Transcriptional regulator
T303_RS07780	COG3064	Membrane
T303_RS07785	COG0488	(ABC) transporter
T303_RS07845	COG2197	response regulator
T303_RS07850	COG4585	Histidine kinase
T303_RS07860	COG0515	serine threonine protein kinase
T303_RS07860	COG2815	serine threonine protein kinase
T303_RS07870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
T303_RS07870	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
T303_RS07880	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
T303_RS07895	COG0552	protein localization to endoplasmic reticulum
T303_RS07900	COG0561	phosphatase activity
T303_RS07905	COG0561	phosphatase activity
T303_RS07910	COG1725	Transcriptional regulator
T303_RS07915	COG1131	(ABC) transporter
T303_RS07925	COG4608	Belongs to the ABC transporter superfamily
T303_RS07930	COG0444	Belongs to the ABC transporter superfamily
T303_RS07935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
T303_RS07940	COG0601	transmembrane transport
T303_RS07945	COG4166	transmembrane transport
T303_RS07955	COG4166	transmembrane transport
T303_RS07965	COG2801	Transposase and inactivated derivatives
T303_RS07970	COG4608	Belongs to the ABC transporter superfamily
T303_RS07975	COG4608	Belongs to the ABC transporter superfamily
T303_RS07980	COG0084	hydrolase, TatD family'
T303_RS07985	COG2223	nitrite transmembrane transporter activity
T303_RS07990	COG2801	Transposase and inactivated derivatives
T303_RS08000	COG0280	phosphate acetyltransferase
T303_RS08005	COG0564	pseudouridine synthase activity
T303_RS08015	COG2357	RelA SpoT domain protein
T303_RS08030	COG1104	cysteine desulfurase activity
T303_RS08045	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
T303_RS08050	COG2003	Belongs to the UPF0758 family
T303_RS08075	COG1215	transferase activity, transferring glycosyl groups
T303_RS08090	COG1216	Glycosyl transferase, family 2
T303_RS08090	COG1442	glycosyl transferase family 8
T303_RS08105	COG0463	Glycosyl transferase, family 2
T303_RS08110	COG1091	dTDP-4-dehydrorhamnose reductase activity
T303_RS08120	COG0463	Glycosyl transferase, family 2
T303_RS08125	COG2151	metal-sulfur cluster biosynthetic enzyme
T303_RS08130	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
T303_RS08135	COG0358	DNA primase activity
T303_RS08140	COG1970	mechanosensitive ion channel activity
T303_RS08150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
T303_RS08155	COG0436	Aminotransferase
T303_RS08160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
T303_RS08165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
T303_RS08170	COG1051	belongs to the nudix hydrolase family
T303_RS08195	COG0765	amino acid transport
T303_RS08200	COG1126	abc transporter atp-binding protein
T303_RS08215	COG1187	pseudouridine synthase activity
T303_RS08260	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
T303_RS08265	COG1518	maintenance of DNA repeat elements
T303_RS08270	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
T303_RS08275	COG0560	Phosphoserine phosphatase
T303_RS08285	COG0187	DNA topoisomerase II activity
T303_RS08295	COG1346	cytolysis
T303_RS08300	COG1380	Effector of murein hydrolase LrgA
T303_RS08310	COG1393	Belongs to the ArsC family
T303_RS08320	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
T303_RS08360	COG1177	transmembrane transport
T303_RS08365	COG1176	ABC-type spermidine putrescine transport system, permease component I
T303_RS08405	COG0531	amino acid
T303_RS08410	COG0285	dihydrofolate synthase activity
T303_RS08415	COG1837	Belongs to the UPF0109 family
T303_RS08425	COG3615	Tellurite resistance protein tehB
T303_RS08425	COG0500	methyltransferase
T303_RS08435	COG0708	Exodeoxyribonuclease III
T303_RS08450	COG1597	lipid kinase activity
T303_RS08460	COG4708	membrane
T303_RS08470	COG0024	Methionine aminopeptidase
T303_RS08475	COG4109	DRTGG domain
T303_RS08485	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
T303_RS08490	COG2333	competence protein COMEC
T303_RS08490	COG0658	competence protein
T303_RS08495	COG1596	polysaccharide export
T303_RS08495	COG1555	photosystem II stabilization
T303_RS08500	COG0204	Acyl-transferase
T303_RS08505	COG0726	polysaccharide deacetylase
T303_RS08510	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
T303_RS08520	COG0513	Belongs to the DEAD box helicase family
T303_RS08540	COG1396	sequence-specific DNA binding
T303_RS08545	COG2211	Major facilitator Superfamily
T303_RS08560	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
T303_RS08575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
T303_RS08580	COG1126	abc transporter atp-binding protein
T303_RS08585	COG0765	amino acid transport
T303_RS08590	COG0765	amino acid transport
T303_RS08605	COG2217	Heavy metal translocating P-type atpase
T303_RS08615	COG0159	tryptophan synthase activity
T303_RS08625	COG0135	phosphoribosylanthranilate isomerase activity
T303_RS08640	COG0512	Glutamine amidotransferase of anthranilate synthase
T303_RS08645	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
T303_RS08650	COG1605	Chorismate mutase
T303_RS08650	COG0287	Prephenate dehydrogenase
T303_RS08660	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
T303_RS08685	COG2176	DNA-directed DNA polymerase activity
T303_RS08695	COG2151	metal-sulfur cluster biosynthetic enzyme
T303_RS08705	COG2081	HI0933 family
T303_RS08730	COG1131	(ABC) transporter
T303_RS08735	COG0537	adenosine 5'-monophosphoramidase activity
T303_RS08765	COG2226	methyltransferase
T303_RS08770	COG0799	negative regulation of ribosome biogenesis
T303_RS08775	COG1713	HD superfamily hydrolase involved in NAD metabolism
T303_RS08780	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
T303_RS08785	COG1534	Rna-binding protein
T303_RS08790	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
T303_RS08795	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
T303_RS08830	COG2723	6-phospho-beta-galactosidase activity
T303_RS08845	COG1335	isochorismatase
T303_RS08855	COG0436	Aminotransferase
T303_RS08860	COG0589	response to stress
T303_RS08875	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
T303_RS08880	COG1253	flavin adenine dinucleotide binding
T303_RS08885	COG1119	ATPase activity
T303_RS08890	COG0025	NhaP-type Na H and K H
T303_RS08900	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
T303_RS08905	COG1242	4 iron, 4 sulfur cluster binding
T303_RS08910	COG3480	Lon protease (S16) C-terminal proteolytic domain
T303_RS08915	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
T303_RS08920	COG0742	ribosomal rna small subunit methyltransferase
T303_RS08925	COG0492	ferredoxin-NADP+ reductase activity
T303_RS08935	COG1126	abc transporter atp-binding protein
T303_RS08945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
T303_RS08960	COG1882	Formate acetyltransferase
T303_RS08985	COG0390	transport system, permease component
T303_RS08990	COG4619	ABC transporter
T303_RS08995	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
T303_RS09010	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
T303_RS09045	COG2801	Transposase and inactivated derivatives
T303_RS09100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
T303_RS09110	COG1132	(ABC) transporter
T303_RS09115	COG1132	(ABC) transporter
T303_RS09130	COG0820	rRNA (adenine-C2-)-methyltransferase activity
T303_RS09135	COG4470	Protein conserved in bacteria
T303_RS09140	COG0737	Belongs to the 5'-nucleotidase family
T303_RS09145	COG0513	Belongs to the DEAD box helicase family
T303_RS09155	COG0768	penicillin binding
T303_RS09190	COG3152	Membrane
T303_RS09200	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
T303_RS09215	COG4152	abc transporter atp-binding protein
T303_RS09220	COG1811	Na channel or pump
T303_RS09260	COG0561	phosphatase activity
T303_RS09265	COG0252	asparaginase activity
T303_RS09270	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
T303_RS09275	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
T303_RS09285	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
T303_RS09290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
T303_RS09305	COG1482	cell wall glycoprotein biosynthetic process
T303_RS09310	COG1940	carbohydrate kinase activity
T303_RS09315	COG1263	PTS System
T303_RS09315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
T303_RS09315	COG2190	(PTS) system
T303_RS09320	COG1621	beta-fructofuranosidase activity
T303_RS09325	COG1609	Transcriptional regulator
T303_RS09345	COG2131	deaminase
T303_RS09350	COG0006	proline dipeptidase activity
T303_RS09365	COG1131	(ABC) transporter
T303_RS09440	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
T303_RS09440	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
T303_RS09465	COG0681	Belongs to the peptidase S26 family
T303_RS09470	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
T303_RS09480	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
T303_RS09490	COG0456	acetyltransferase
T303_RS09495	COG1214	PFAM Peptidase M22, glycoprotease
T303_RS09515	COG0174	glutamine synthetase
T303_RS09520	COG0789	Transcriptional regulator
T303_RS09560	COG2801	Transposase and inactivated derivatives
T303_RS09595	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
T303_RS09640	COG0084	hydrolase, TatD family'
T303_RS09645	COG1832	CoA-binding protein
T303_RS09650	COG3118	belongs to the thioredoxin family
T303_RS09715	COG4166	transmembrane transport
T303_RS09720	COG4166	transmembrane transport
T303_RS09730	COG0588	phosphoglycerate mutase activity