locus-tag	class	description
E3C75_RS00010	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E3C75_RS00105	COG3290	protein histidine kinase activity
E3C75_RS00115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3C75_RS00120	COG2274	protein secretion by the type I secretion system
E3C75_RS00125	COG1132	(ABC) transporter
E3C75_RS00130	COG1132	(ABC) transporter
E3C75_RS00150	COG4470	Protein conserved in bacteria
E3C75_RS00155	COG0737	Belongs to the 5'-nucleotidase family
E3C75_RS00165	COG0513	Belongs to the DEAD box helicase family
E3C75_RS00175	COG0768	penicillin binding
E3C75_RS00205	COG3152	Membrane
E3C75_RS00215	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E3C75_RS00220	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E3C75_RS00230	COG4152	abc transporter atp-binding protein
E3C75_RS00235	COG1811	Na channel or pump
E3C75_RS00245	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
E3C75_RS00275	COG0561	phosphatase activity
E3C75_RS00280	COG0252	asparaginase activity
E3C75_RS00285	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E3C75_RS00300	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E3C75_RS00305	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E3C75_RS00310	COG0653	protein targeting
E3C75_RS00320	COG1482	cell wall glycoprotein biosynthetic process
E3C75_RS00325	COG1940	carbohydrate kinase activity
E3C75_RS00330	COG2190	(PTS) system
E3C75_RS00330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3C75_RS00330	COG1263	PTS System
E3C75_RS00335	COG1621	beta-fructofuranosidase activity
E3C75_RS00340	COG1609	Transcriptional regulator
E3C75_RS00355	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E3C75_RS00360	COG2131	deaminase
E3C75_RS00365	COG0006	proline dipeptidase activity
E3C75_RS00380	COG1131	(ABC) transporter
E3C75_RS00455	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3C75_RS00455	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3C75_RS00495	COG3843	relaxase mobilization nuclease domain protein
E3C75_RS00555	COG3942	CHAP domain
E3C75_RS00555	COG1705	Flagellar rod assembly protein muramidase FlgJ
E3C75_RS00610	COG0681	Belongs to the peptidase S26 family
E3C75_RS00615	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E3C75_RS00625	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E3C75_RS00635	COG0456	acetyltransferase
E3C75_RS00640	COG1214	PFAM Peptidase M22, glycoprotease
E3C75_RS00660	COG0174	glutamine synthetase
E3C75_RS00665	COG0789	Transcriptional regulator
E3C75_RS00720	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E3C75_RS00765	COG0084	hydrolase, TatD family'
E3C75_RS00770	COG1832	CoA-binding protein
E3C75_RS00775	COG3118	belongs to the thioredoxin family
E3C75_RS00845	COG0706	membrane insertase activity
E3C75_RS00905	COG0756	dUTP diphosphatase activity
E3C75_RS00915	COG0431	NADPH-dependent FMN reductase
E3C75_RS00915	COG3976	FMN-binding domain protein
E3C75_RS00915	COG1053	succinate dehydrogenase
E3C75_RS00935	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E3C75_RS00940	COG0457	Tetratricopeptide repeat
E3C75_RS00940	COG0705	Rhomboid family
E3C75_RS00945	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E3C75_RS00965	COG2226	methyltransferase
E3C75_RS00995	COG0425	Belongs to the sulfur carrier protein TusA family
E3C75_RS01000	COG2391	methyltransferase activity
E3C75_RS01005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3C75_RS01010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3C75_RS01020	COG1363	Peptidase, m42
E3C75_RS01025	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E3C75_RS01030	COG1266	CAAX protease self-immunity
E3C75_RS01085	COG1459	type II secretion system
E3C75_RS01090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E3C75_RS01125	COG0440	acetolactate synthase activity
E3C75_RS01130	COG0028	Belongs to the TPP enzyme family
E3C75_RS01135	COG0129	dihydroxy-acid dehydratase activity
E3C75_RS01140	COG1461	Dihydroxyacetone kinase
E3C75_RS01150	COG0534	Mate efflux family protein
E3C75_RS01165	COG3590	peptidase
E3C75_RS01190	COG2188	Transcriptional regulator
E3C75_RS01195	COG4475	Protein of unknown function (DUF436)
E3C75_RS01235	COG2217	Heavy metal translocating P-type atpase
E3C75_RS01240	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E3C75_RS01295	COG0191	fructose-bisphosphate aldolase activity
E3C75_RS01365	COG0201	protein transport
E3C75_RS01470	COG0051	transcription antitermination factor activity, RNA binding
E3C75_RS01515	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E3C75_RS01520	COG3328	transposase activity
E3C75_RS01540	COG1396	sequence-specific DNA binding
E3C75_RS01545	COG0535	radical SAM domain protein
E3C75_RS01550	COG1132	(ABC) transporter
E3C75_RS01585	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E3C75_RS01625	COG0602	queuosine metabolic process
E3C75_RS01635	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E3C75_RS01660	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E3C75_RS01670	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E3C75_RS01695	COG2261	transglycosylase associated protein
E3C75_RS01715	COG3237	CsbD-like
E3C75_RS01725	COG3328	transposase activity
E3C75_RS01745	COG1511	domain protein
E3C75_RS01745	COG1511	domain protein
E3C75_RS01775	COG0305	Participates in initiation and elongation during chromosome replication
E3C75_RS01815	COG0741	lytic transglycosylase activity
E3C75_RS01820	COG1388	LysM domain
E3C75_RS01820	COG3584	3D domain protein
E3C75_RS01825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E3C75_RS01840	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E3C75_RS01850	COG0612	Peptidase, M16
E3C75_RS01885	COG0488	(ABC) transporter
E3C75_RS01920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3C75_RS01925	COG1475	DNA binding
E3C75_RS01935	COG0592	DNA-directed DNA polymerase activity
E3C75_RS01945	COG0012	GTP binding
E3C75_RS01955	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E3C75_RS01960	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E3C75_RS01990	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E3C75_RS02120	COG3942	CHAP domain
E3C75_RS02135	COG0436	Aminotransferase
E3C75_RS02150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3C75_RS02160	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E3C75_RS02170	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E3C75_RS02175	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E3C75_RS02195	COG0151	Belongs to the GarS family
E3C75_RS02200	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E3C75_RS02220	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E3C75_RS02230	COG0582	viral genome integration into host DNA
E3C75_RS02305	COG4550	Control of competence regulator ComK, YlbF/YmcA
E3C75_RS02345	COG2818	Glycosylase
E3C75_RS02360	COG1393	Belongs to the ArsC family
E3C75_RS02450	COG2309	aminopeptidase activity
E3C75_RS02475	COG1619	proteins homologs of microcin C7 resistance protein MccF
E3C75_RS02500	COG4463	regulation of RNA biosynthetic process
E3C75_RS02505	COG0542	response to heat
E3C75_RS02515	COG1686	Belongs to the peptidase S11 family
E3C75_RS02530	COG1045	serine acetyltransferase
E3C75_RS02540	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
E3C75_RS02555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3C75_RS02580	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E3C75_RS02665	COG3830	Belongs to the UPF0237 family
E3C75_RS02675	COG0588	phosphoglycerate mutase activity
E3C75_RS02680	COG1876	peptidase activity
E3C75_RS02715	COG0351	phosphomethylpyrimidine kinase
E3C75_RS02720	COG4720	Psort location CytoplasmicMembrane, score
E3C75_RS02765	COG0668	transmembrane transport
E3C75_RS02780	COG0504	CTP synthase activity
E3C75_RS02800	COG0270	DNA (cytosine-5-)-methyltransferase activity
E3C75_RS02950	COG1396	sequence-specific DNA binding
E3C75_RS02955	COG0542	response to heat
E3C75_RS02965	COG4581	dead DEAH box helicase
E3C75_RS02985	COG3843	relaxase mobilization nuclease domain protein
E3C75_RS03010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3C75_RS03080	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E3C75_RS03120	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E3C75_RS03155	COG1126	abc transporter atp-binding protein
E3C75_RS03160	COG0765	amino acid transport
E3C75_RS03180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E3C75_RS03190	COG0719	Fe-S assembly protein
E3C75_RS03195	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E3C75_RS03205	COG0719	Fe-S assembly protein
E3C75_RS03245	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E3C75_RS03270	COG1121	(ABC) transporter
E3C75_RS03275	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E3C75_RS03315	COG4589	Belongs to the CDS family
E3C75_RS03330	COG4120	Belongs to the binding-protein-dependent transport system permease family
E3C75_RS03335	COG1116	anion transmembrane transporter activity
E3C75_RS03335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E3C75_RS03355	COG2801	Transposase and inactivated derivatives
E3C75_RS03360	COG2801	Transposase and inactivated derivatives
E3C75_RS03380	COG0564	pseudouridine synthase activity
E3C75_RS03385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E3C75_RS03450	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E3C75_RS03465	COG3579	cysteine-type endopeptidase activity
E3C75_RS03470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E3C75_RS03495	COG0116	Belongs to the methyltransferase superfamily
E3C75_RS03505	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E3C75_RS03525	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E3C75_RS03550	COG1254	Belongs to the acylphosphatase family
E3C75_RS03555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3C75_RS03600	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E3C75_RS03620	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E3C75_RS03625	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E3C75_RS03630	COG1187	pseudouridine synthase activity
E3C75_RS03640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E3C75_RS03645	COG0569	domain protein
E3C75_RS03655	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
E3C75_RS03660	COG0671	phosphoesterase, PA-phosphatase related
E3C75_RS03675	COG2274	protein secretion by the type I secretion system
E3C75_RS03680	COG2274	protein secretion by the type I secretion system
E3C75_RS03685	COG2274	protein secretion by the type I secretion system
E3C75_RS03725	COG0804	urea catabolic process
E3C75_RS03745	COG0829	nickel cation binding
E3C75_RS03750	COG0310	cobalt ion transport
E3C75_RS03760	COG1122	ATPase activity
E3C75_RS03765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3C75_RS03770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3C75_RS03790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3C75_RS03800	COG1464	Belongs to the NlpA lipoprotein family
E3C75_RS03810	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E3C75_RS03820	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E3C75_RS03835	COG1122	ATPase activity
E3C75_RS03845	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E3C75_RS03855	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E3C75_RS03870	COG0745	RESPONSE REGULATOR receiver
E3C75_RS03875	COG5002	protein histidine kinase activity
E3C75_RS03890	COG1484	DNA-dependent DNA replication
E3C75_RS03905	COG1335	isochorismatase
E3C75_RS03940	COG3716	PTS system mannose fructose sorbose family IID component
E3C75_RS03945	COG3715	PTS system
E3C75_RS03955	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
E3C75_RS03960	COG0561	phosphatase activity
E3C75_RS03965	COG2252	PERMEase
E3C75_RS03970	COG0802	atpase or kinase
E3C75_RS03975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3C75_RS03980	COG1316	TRANSCRIPTIONal
E3C75_RS03990	COG0195	Participates in both transcription termination and antitermination
E3C75_RS03995	COG2740	Nucleic-acid-binding protein implicated in transcription termination
E3C75_RS04005	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E3C75_RS04030	COG2244	polysaccharide biosynthetic process
E3C75_RS04040	COG0626	cystathionine gamma-synthase activity
E3C75_RS04045	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E3C75_RS04075	COG4471	UPF0298 protein
E3C75_RS04085	COG0559	Belongs to the binding-protein-dependent transport system permease family
E3C75_RS04115	COG1739	Uncharacterized protein family UPF0029
E3C75_RS04120	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
E3C75_RS04125	COG1040	competence protein
E3C75_RS04190	COG3328	transposase activity
E3C75_RS04220	COG0527	aspartate kinase activity
E3C75_RS04225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3C75_RS04230	COG1024	Enoyl-CoA hydratase
E3C75_RS04235	COG1846	Transcriptional regulator
E3C75_RS04255	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E3C75_RS04260	COG1028	Short-chain dehydrogenase reductase Sdr
E3C75_RS04265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E3C75_RS04280	COG0439	Biotin carboxylase
E3C75_RS04310	COG1349	DNA-binding transcription factor activity
E3C75_RS04315	COG1105	Belongs to the carbohydrate kinase PfkB family
E3C75_RS04320	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3C75_RS04320	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3C75_RS04320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3C75_RS04325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3C75_RS04330	COG0285	dihydrofolate synthase activity
E3C75_RS04340	COG1104	cysteine desulfurase activity
E3C75_RS04400	COG0488	(ABC) transporter
E3C75_RS04420	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E3C75_RS04425	COG0242	peptide deformylase activity
E3C75_RS04475	COG3942	CHAP domain
E3C75_RS04485	COG1702	phosphate starvation-inducible protein PhoH
E3C75_RS04505	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3C75_RS04505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3C75_RS04530	COG4122	O-methyltransferase activity
E3C75_RS04535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3C75_RS04645	COG3843	relaxase mobilization nuclease domain protein
E3C75_RS04670	COG1192	Involved in chromosome partitioning
E3C75_RS04680	COG3177	Filamentation induced by cAMP protein fic
E3C75_RS04720	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E3C75_RS04725	COG0436	Aminotransferase
E3C75_RS04740	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E3C75_RS04745	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E3C75_RS04750	COG0726	polysaccharide deacetylase
E3C75_RS04765	COG2962	Rard protein
E3C75_RS04800	COG0356	it plays a direct role in the translocation of protons across the membrane
E3C75_RS04835	COG0772	Belongs to the SEDS family
E3C75_RS04855	COG0470	DNA polymerase III
E3C75_RS04860	COG1774	PSP1 C-terminal conserved region
E3C75_RS04865	COG4467	Involved in initiation control of chromosome replication
E3C75_RS04880	COG0004	ammonium transporteR
E3C75_RS04885	COG0347	Belongs to the P(II) protein family
E3C75_RS04890	COG1705	Flagellar rod assembly protein muramidase FlgJ
E3C75_RS04890	COG1388	LysM domain
E3C75_RS04945	COG1113	amino acid transport
E3C75_RS04955	COG2190	(PTS) system
E3C75_RS04955	COG1263	PTS System
E3C75_RS04955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3C75_RS04965	COG2190	(PTS) system
E3C75_RS04965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3C75_RS04965	COG1263	PTS System
E3C75_RS05005	COG0564	pseudouridine synthase activity
E3C75_RS05025	COG0505	Belongs to the CarA family
E3C75_RS05070	COG0270	DNA (cytosine-5-)-methyltransferase activity
E3C75_RS05160	COG2205	protein histidine kinase activity
E3C75_RS05165	COG0745	RESPONSE REGULATOR receiver
E3C75_RS05195	COG1396	sequence-specific DNA binding
E3C75_RS05205	COG4974	Belongs to the 'phage' integrase family
E3C75_RS05225	COG0577	efflux transmembrane transporter activity
E3C75_RS05275	COG3279	Response regulator of the LytR AlgR family
E3C75_RS05285	COG1131	(ABC) transporter
E3C75_RS05320	COG1187	pseudouridine synthase activity
E3C75_RS05325	COG1473	amidohydrolase
E3C75_RS05330	COG0686	Belongs to the AlaDH PNT family
E3C75_RS05335	COG0686	Belongs to the AlaDH PNT family
E3C75_RS05340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3C75_RS05355	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E3C75_RS05410	COG0438	transferase activity, transferring glycosyl groups
E3C75_RS05445	COG1272	protein, Hemolysin III
E3C75_RS05460	COG3425	synthase
E3C75_RS05470	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E3C75_RS05485	COG0833	amino acid
E3C75_RS05490	COG2040	homocysteine
E3C75_RS05510	COG0187	DNA topoisomerase II activity
E3C75_RS05520	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E3C75_RS05540	COG0539	negative regulation of cytoplasmic translation
E3C75_RS05580	COG0494	nUDIX hydrolase
E3C75_RS05585	COG0542	response to heat
E3C75_RS05590	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E3C75_RS05595	COG4703	Protein of unknown function (DUF1797)
E3C75_RS05640	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E3C75_RS05645	COG0768	penicillin binding
E3C75_RS05650	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E3C75_RS05660	COG3711	transcriptional antiterminator
E3C75_RS05670	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E3C75_RS05675	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E3C75_RS05680	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E3C75_RS05685	COG0237	dephospho-CoA kinase activity
E3C75_RS05690	COG2814	Major facilitator Superfamily
E3C75_RS05705	COG0557	exoribonuclease II activity
E3C75_RS05720	COG1185	polyribonucleotide nucleotidyltransferase activity
E3C75_RS05725	COG0006	proline dipeptidase activity
E3C75_RS05730	COG1609	Transcriptional regulator
E3C75_RS05760	COG0582	viral genome integration into host DNA
E3C75_RS05810	COG3935	DnaD domain protein
E3C75_RS06030	COG1368	sulfuric ester hydrolase activity
E3C75_RS06035	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E3C75_RS06060	COG0287	Prephenate dehydrogenase
E3C75_RS06085	COG0077	Prephenate dehydratase
E3C75_RS06200	COG1518	maintenance of DNA repeat elements
E3C75_RS06205	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
E3C75_RS06215	COG3689	TIGRFAM TIGR03943 family protein
E3C75_RS06220	COG0701	Predicted permease
E3C75_RS06225	COG2183	response to ionizing radiation
E3C75_RS06245	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E3C75_RS06280	COG1268	BioY protein
E3C75_RS06290	COG4443	Transcriptional Coactivator p15 (PC4)
E3C75_RS06295	COG1914	H( )-stimulated, divalent metal cation uptake system
E3C75_RS06320	COG3328	transposase activity
E3C75_RS06350	COG0406	alpha-ribazole phosphatase activity
E3C75_RS06355	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E3C75_RS06400	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E3C75_RS06440	COG1704	LemA family
E3C75_RS06445	COG0501	Belongs to the peptidase M48B family
E3C75_RS06470	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E3C75_RS06485	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E3C75_RS06490	COG0783	Belongs to the Dps family
E3C75_RS06500	COG0783	Belongs to the Dps family
E3C75_RS06505	COG0735	belongs to the Fur family
E3C75_RS06510	COG4483	Protein conserved in bacteria
E3C75_RS06515	COG1940	carbohydrate kinase activity
E3C75_RS06555	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E3C75_RS06580	COG3599	regulation of cell shape
E3C75_RS06610	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E3C75_RS06615	COG0625	glutathione transferase activity
E3C75_RS06620	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E3C75_RS06625	COG1435	thymidine kinase activity
E3C75_RS06635	COG2890	protein-(glutamine-N5) methyltransferase activity
E3C75_RS06665	COG1132	(ABC) transporter
E3C75_RS06680	COG1696	Membrane protein involved in D-alanine export
E3C75_RS06690	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
E3C75_RS06695	COG2801	Transposase and inactivated derivatives
E3C75_RS06705	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E3C75_RS06710	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E3C75_RS06730	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E3C75_RS06735	COG4684	Psort location CytoplasmicMembrane, score
E3C75_RS06740	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E3C75_RS06755	COG0745	RESPONSE REGULATOR receiver
E3C75_RS06770	COG5002	protein histidine kinase activity
E3C75_RS06790	COG2813	Specifically methylates the guanine in position
E3C75_RS06810	COG1744	ABC transporter substrate-binding protein PnrA-like
E3C75_RS06835	COG1199	ATP-dependent helicase activity
E3C75_RS06835	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3C75_RS06845	COG0436	Aminotransferase
E3C75_RS06850	COG0017	Asparaginyl-tRNA synthetase
E3C75_RS06865	COG0251	oxidation-reduction process
E3C75_RS06875	COG0720	synthase
E3C75_RS06910	COG4975	Glucose uptake
E3C75_RS06920	COG3328	transposase activity
E3C75_RS06975	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
E3C75_RS07110	COG0551	DNA topoisomerase type I activity
E3C75_RS07110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E3C75_RS07115	COG0542	response to heat
E3C75_RS07145	COG1472	Belongs to the glycosyl hydrolase 3 family
E3C75_RS07175	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E3C75_RS07245	COG0803	Belongs to the bacterial solute-binding protein 9 family
E3C75_RS07245	COG3443	Belongs to the bacterial solute-binding protein 9 family
E3C75_RS07265	COG1705	Flagellar rod assembly protein muramidase FlgJ
E3C75_RS07265	COG3942	CHAP domain
E3C75_RS07280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E3C75_RS07285	COG2824	Alkylphosphonate utilization operon protein PhnA
E3C75_RS07290	COG0765	amino acid transport
E3C75_RS07295	COG1126	abc transporter atp-binding protein
E3C75_RS07300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3C75_RS07320	COG1064	alcohol dehydrogenase
E3C75_RS07325	COG1064	alcohol dehydrogenase
E3C75_RS07335	COG3421	Type III restriction
E3C75_RS07340	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E3C75_RS07345	COG0519	Catalyzes the synthesis of GMP from XMP
E3C75_RS07345	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E3C75_RS07350	COG2188	Transcriptional regulator
E3C75_RS07360	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E3C75_RS07370	COG1827	regulation of RNA biosynthetic process
E3C75_RS07380	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E3C75_RS07395	COG0758	DNA mediated transformation
E3C75_RS07400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E3C75_RS07445	COG0481	GTPase activity
E3C75_RS07475	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E3C75_RS07480	COG0010	Belongs to the arginase family
E3C75_RS07490	COG0028	Belongs to the TPP enzyme family
E3C75_RS07495	COG3527	Alpha-acetolactate decarboxylase
E3C75_RS07525	COG1230	cation diffusion facilitator family transporter
E3C75_RS07535	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E3C75_RS07565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3C75_RS07585	COG1293	RNA-binding protein homologous to eukaryotic snRNP
E3C75_RS07610	COG0167	dihydroorotate dehydrogenase activity
E3C75_RS07615	COG0284	orotidine-5'-phosphate decarboxylase activity
E3C75_RS07635	COG3104	oligopeptide transport
E3C75_RS07640	COG0154	amidase activity
E3C75_RS07675	COG1115	amino acid carrier protein
E3C75_RS07685	COG2873	o-acetylhomoserine
E3C75_RS07715	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E3C75_RS07720	COG0196	riboflavin kinase activity
E3C75_RS07725	COG1393	Belongs to the ArsC family
E3C75_RS07735	COG0483	inositol monophosphate 1-phosphatase activity
E3C75_RS07740	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E3C75_RS07740	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
E3C75_RS07750	COG0573	inorganic phosphate transmembrane transporter activity
E3C75_RS07755	COG0581	inorganic phosphate transmembrane transporter activity
E3C75_RS07770	COG0704	Plays a role in the regulation of phosphate uptake
E3C75_RS07785	COG0095	Lipoate-protein ligase
E3C75_RS07800	COG0058	SHG alpha-glucan phosphorylase activity
E3C75_RS07805	COG1640	4-alpha-glucanotransferase
E3C75_RS07815	COG1609	Transcriptional regulator
E3C75_RS07840	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3C75_RS07845	COG0805	protein transport
E3C75_RS07850	COG0672	)-iron permease
E3C75_RS07855	COG2837	iron assimilation
E3C75_RS07860	COG2822	iron ion transport
E3C75_RS07875	COG1523	belongs to the glycosyl hydrolase 13 family
E3C75_RS07885	COG1523	belongs to the glycosyl hydrolase 13 family
E3C75_RS07905	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3C75_RS07910	COG0022	dehydrogenase e1 component
E3C75_RS07910	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3C75_RS07915	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E3C75_RS07935	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E3C75_RS07945	COG4667	esterase of the alpha-beta hydrolase superfamily
E3C75_RS07990	COG0628	permease
E3C75_RS07995	COG0406	alpha-ribazole phosphatase activity
E3C75_RS08020	COG0438	transferase activity, transferring glycosyl groups
E3C75_RS08025	COG0562	UDP-galactopyranose mutase
E3C75_RS08040	COG1216	Glycosyl transferase, family 2
E3C75_RS08045	COG1216	Glycosyl transferase, family 2
E3C75_RS08045	COG1442	glycosyl transferase family 8
E3C75_RS08055	COG1442	glycosyl transferase family 8
E3C75_RS08055	COG1216	Glycosyl transferase, family 2
E3C75_RS08065	COG0297	glycogen (starch) synthase activity
E3C75_RS08075	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E3C75_RS08095	COG1316	TRANSCRIPTIONal
E3C75_RS08115	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E3C75_RS08150	COG1573	uracil-dna glycosylase
E3C75_RS08180	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E3C75_RS08185	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E3C75_RS08215	COG0681	Belongs to the peptidase S26 family
E3C75_RS08225	COG0628	permease
E3C75_RS08230	COG1051	belongs to the nudix hydrolase family
E3C75_RS08235	COG2177	Part of the ABC transporter FtsEX involved in
E3C75_RS08240	COG2884	Cell division ATP-binding protein ftsE
E3C75_RS08250	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E3C75_RS08285	COG2348	transferase activity, transferring amino-acyl groups
E3C75_RS08295	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E3C75_RS08300	COG5002	protein histidine kinase activity
E3C75_RS08305	COG0745	RESPONSE REGULATOR receiver
E3C75_RS08310	COG1126	abc transporter atp-binding protein
E3C75_RS08315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3C75_RS08320	COG0765	amino acid transport
E3C75_RS08325	COG0765	amino acid transport
E3C75_RS08350	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E3C75_RS08360	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E3C75_RS08365	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E3C75_RS08365	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E3C75_RS08375	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E3C75_RS08380	COG1956	GAF domain-containing protein
E3C75_RS08385	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E3C75_RS08400	COG0335	large ribosomal subunit rRNA binding
E3C75_RS08405	COG0038	chloride channel
E3C75_RS08415	COG0038	chloride channel
E3C75_RS08420	COG0716	FMN binding
E3C75_RS08485	COG0469	pyruvate kinase activity
E3C75_RS08535	COG0167	dihydroorotate dehydrogenase activity
E3C75_RS08545	COG0776	regulation of translation
E3C75_RS08560	COG1307	EDD domain protein, DegV family
E3C75_RS08565	COG0497	DNA recombination
E3C75_RS08570	COG1438	arginine binding
E3C75_RS08575	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
E3C75_RS08600	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E3C75_RS08620	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E3C75_RS08620	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E3C75_RS08625	COG0300	oxidoreductase activity
E3C75_RS08640	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E3C75_RS08645	COG0772	Belongs to the SEDS family
E3C75_RS08660	COG0107	imidazoleglycerol-phosphate synthase activity
E3C75_RS08670	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E3C75_RS08680	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E3C75_RS08730	COG0647	UMP catabolic process
E3C75_RS08740	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E3C75_RS08750	COG3328	transposase activity
E3C75_RS08770	COG1088	dTDP-glucose 4,6-dehydratase activity
E3C75_RS08780	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E3C75_RS08785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3C75_RS08800	COG2384	SAM-dependent methyltransferase
E3C75_RS08825	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E3C75_RS08830	COG3442	glutamine amidotransferase
E3C75_RS08835	COG0392	lysyltransferase activity
E3C75_RS08835	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
E3C75_RS08845	COG0488	(ABC) transporter
E3C75_RS08855	COG0513	Belongs to the DEAD box helicase family
E3C75_RS08885	COG0372	Belongs to the citrate synthase family
E3C75_RS08890	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E3C75_RS08895	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E3C75_RS08900	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3C75_RS08905	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3C75_RS08935	COG3764	Sortase (surface protein transpeptidase)
E3C75_RS08955	COG0488	(ABC) transporter
E3C75_RS08985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3C75_RS08990	COG1328	CTP reductase activity
E3C75_RS08990	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E3C75_RS09020	COG1196	nuclear chromosome segregation
E3C75_RS09035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E3C75_RS09045	COG1247	-acetyltransferase
E3C75_RS09055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E3C75_RS09070	COG1268	BioY protein
E3C75_RS09080	COG0517	IMP dehydrogenase activity
E3C75_RS09080	COG1125	glycine betaine transport
E3C75_RS09095	COG2986	histidine ammonia-lyase
E3C75_RS09105	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E3C75_RS09115	COG2197	response regulator
E3C75_RS09120	COG4585	Histidine kinase
E3C75_RS09130	COG1131	(ABC) transporter
E3C75_RS09145	COG0385	Bile acid
E3C75_RS09165	COG0577	efflux transmembrane transporter activity
E3C75_RS09170	COG1136	(ABC) transporter
E3C75_RS09175	COG5002	protein histidine kinase activity
E3C75_RS09175	COG0784	Response regulator, receiver
E3C75_RS09175	COG2198	Histidine kinase
E3C75_RS09180	COG0745	RESPONSE REGULATOR receiver
E3C75_RS09195	COG0534	Mate efflux family protein
E3C75_RS09200	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E3C75_RS09200	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E3C75_RS09215	COG1126	abc transporter atp-binding protein
E3C75_RS09220	COG0765	amino acid transport
E3C75_RS09230	COG2079	MmgE PrpD family protein
E3C75_RS09235	COG0436	Aminotransferase
E3C75_RS09245	COG1473	amidohydrolase
E3C75_RS09270	COG0531	amino acid
E3C75_RS09290	COG1126	abc transporter atp-binding protein
E3C75_RS09295	COG0765	amino acid transport
E3C75_RS09300	COG0765	amino acid transport
E3C75_RS09305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3C75_RS09315	COG0386	Belongs to the glutathione peroxidase family
E3C75_RS09350	COG2514	catechol 2,3-dioxygenase activity
E3C75_RS09360	COG1959	2 iron, 2 sulfur cluster binding
E3C75_RS09370	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E3C75_RS09375	COG0778	Nitroreductase
E3C75_RS09385	COG0656	L-ascorbic acid biosynthetic process
E3C75_RS09390	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E3C75_RS09430	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E3C75_RS09450	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E3C75_RS09470	COG1216	Glycosyl transferase, family 2
E3C75_RS09470	COG1442	glycosyl transferase family 8
E3C75_RS09520	COG0419	ATPase involved in DNA repair
E3C75_RS09525	COG0420	3'-5' exonuclease activity
E3C75_RS09535	COG3250	beta-galactosidase activity
E3C75_RS09540	COG2211	Major facilitator Superfamily
E3C75_RS09540	COG2190	(PTS) system
E3C75_RS09545	COG2017	converts alpha-aldose to the beta-anomer
E3C75_RS09550	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E3C75_RS09590	COG0488	(ABC) transporter
E3C75_RS09635	COG3328	transposase activity
E3C75_RS09655	COG2801	Transposase and inactivated derivatives
E3C75_RS09660	COG2801	Transposase and inactivated derivatives
E3C75_RS09665	COG2963	transposase activity
E3C75_RS09710	COG2197	response regulator
E3C75_RS09715	COG4585	Histidine kinase
E3C75_RS09730	COG0515	serine threonine protein kinase
E3C75_RS09730	COG2815	serine threonine protein kinase
E3C75_RS09740	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E3C75_RS09740	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E3C75_RS09750	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E3C75_RS09765	COG0552	protein localization to endoplasmic reticulum
E3C75_RS09770	COG0561	phosphatase activity
E3C75_RS09775	COG0561	phosphatase activity
E3C75_RS09780	COG1725	Transcriptional regulator
E3C75_RS09785	COG1131	(ABC) transporter
E3C75_RS09795	COG4608	Belongs to the ABC transporter superfamily
E3C75_RS09800	COG0444	Belongs to the ABC transporter superfamily
E3C75_RS09805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3C75_RS09810	COG0601	transmembrane transport
E3C75_RS09815	COG4166	transmembrane transport
E3C75_RS09825	COG4608	Belongs to the ABC transporter superfamily
E3C75_RS09830	COG4608	Belongs to the ABC transporter superfamily
E3C75_RS09835	COG0084	hydrolase, TatD family'
E3C75_RS09840	COG2223	nitrite transmembrane transporter activity
E3C75_RS09850	COG0280	phosphate acetyltransferase
E3C75_RS09855	COG0564	pseudouridine synthase activity
E3C75_RS09865	COG2357	RelA SpoT domain protein
E3C75_RS09880	COG1104	cysteine desulfurase activity
E3C75_RS09895	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E3C75_RS09930	COG1215	transferase activity, transferring glycosyl groups
E3C75_RS09950	COG1216	Glycosyl transferase, family 2
E3C75_RS09955	COG1216	Glycosyl transferase, family 2
E3C75_RS09960	COG1216	Glycosyl transferase, family 2
E3C75_RS09970	COG1091	dTDP-4-dehydrorhamnose reductase activity
E3C75_RS09980	COG0463	Glycosyl transferase, family 2
E3C75_RS09985	COG2151	metal-sulfur cluster biosynthetic enzyme
E3C75_RS09990	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E3C75_RS09995	COG0358	DNA primase activity
E3C75_RS10000	COG1970	mechanosensitive ion channel activity
E3C75_RS10010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3C75_RS10015	COG0436	Aminotransferase
E3C75_RS10020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3C75_RS10025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3C75_RS10030	COG1051	belongs to the nudix hydrolase family
E3C75_RS10050	COG0765	amino acid transport
E3C75_RS10055	COG1126	abc transporter atp-binding protein
E3C75_RS10130	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
E3C75_RS10135	COG1518	maintenance of DNA repeat elements
E3C75_RS10140	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
E3C75_RS10145	COG0560	Phosphoserine phosphatase
E3C75_RS10155	COG0187	DNA topoisomerase II activity
E3C75_RS10165	COG1346	cytolysis
E3C75_RS10170	COG1380	Effector of murein hydrolase LrgA
E3C75_RS10180	COG1393	Belongs to the ArsC family
E3C75_RS10190	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E3C75_RS10225	COG1177	transmembrane transport
E3C75_RS10230	COG1176	ABC-type spermidine putrescine transport system, permease component I
E3C75_RS10270	COG0531	amino acid
E3C75_RS10275	COG0285	dihydrofolate synthase activity
E3C75_RS10280	COG1837	Belongs to the UPF0109 family
E3C75_RS10290	COG3615	Tellurite resistance protein tehB
E3C75_RS10290	COG0500	methyltransferase
E3C75_RS10295	COG0708	Exodeoxyribonuclease III
E3C75_RS10310	COG1597	lipid kinase activity
E3C75_RS10320	COG4708	membrane
E3C75_RS10330	COG0024	Methionine aminopeptidase
E3C75_RS10335	COG4109	DRTGG domain
E3C75_RS10350	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E3C75_RS10355	COG0658	competence protein
E3C75_RS10355	COG2333	competence protein COMEC
E3C75_RS10360	COG1596	polysaccharide export
E3C75_RS10360	COG1555	photosystem II stabilization
E3C75_RS10365	COG0204	Acyl-transferase
E3C75_RS10370	COG0726	polysaccharide deacetylase
E3C75_RS10375	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E3C75_RS10385	COG0513	Belongs to the DEAD box helicase family
E3C75_RS10420	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E3C75_RS10440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3C75_RS10445	COG1126	abc transporter atp-binding protein
E3C75_RS10450	COG0765	amino acid transport
E3C75_RS10455	COG0765	amino acid transport
E3C75_RS10470	COG2217	Heavy metal translocating P-type atpase
E3C75_RS10480	COG0159	tryptophan synthase activity
E3C75_RS10490	COG0135	phosphoribosylanthranilate isomerase activity
E3C75_RS10505	COG0512	Glutamine amidotransferase of anthranilate synthase
E3C75_RS10510	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E3C75_RS10515	COG1605	Chorismate mutase
E3C75_RS10515	COG0287	Prephenate dehydrogenase
E3C75_RS10525	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E3C75_RS10550	COG2261	transglycosylase associated protein
E3C75_RS10570	COG3237	CsbD-like
E3C75_RS10575	COG1301	dicarboxylic acid transport
E3C75_RS10620	COG2151	metal-sulfur cluster biosynthetic enzyme
E3C75_RS10630	COG2081	HI0933 family
E3C75_RS10655	COG1131	(ABC) transporter
E3C75_RS10660	COG0537	adenosine 5'-monophosphoramidase activity
E3C75_RS10685	COG3328	transposase activity
E3C75_RS10700	COG2226	methyltransferase
E3C75_RS10705	COG0799	negative regulation of ribosome biogenesis
E3C75_RS10710	COG1713	HD superfamily hydrolase involved in NAD metabolism
E3C75_RS10715	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E3C75_RS10720	COG1534	Rna-binding protein
E3C75_RS10725	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E3C75_RS10730	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
E3C75_RS10785	COG1335	isochorismatase
E3C75_RS10795	COG0436	Aminotransferase
E3C75_RS10800	COG0589	response to stress
E3C75_RS10815	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E3C75_RS10820	COG1253	flavin adenine dinucleotide binding
E3C75_RS10825	COG1119	ATPase activity
E3C75_RS10830	COG0025	NhaP-type Na H and K H
E3C75_RS10840	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
E3C75_RS10845	COG1242	4 iron, 4 sulfur cluster binding
E3C75_RS10850	COG3480	Lon protease (S16) C-terminal proteolytic domain
E3C75_RS10855	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E3C75_RS10860	COG0742	ribosomal rna small subunit methyltransferase
E3C75_RS10865	COG0492	ferredoxin-NADP+ reductase activity
E3C75_RS10875	COG1126	abc transporter atp-binding protein
E3C75_RS10885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3C75_RS10900	COG1882	Formate acetyltransferase
E3C75_RS10940	COG4619	ABC transporter
E3C75_RS10950	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E3C75_RS10970	COG0640	Transcriptional regulator
E3C75_RS10975	COG0697	spore germination
E3C75_RS10990	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E3C75_RS10990	COG0473	3-isopropylmalate dehydrogenase activity
E3C75_RS10995	COG0473	3-isopropylmalate dehydrogenase activity
E3C75_RS10995	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions