locus-tag	class	description
DR994_RS00010	COG0592	DNA-directed DNA polymerase activity
DR994_RS00020	COG0012	GTP binding
DR994_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DR994_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DR994_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DR994_RS00195	COG3942	CHAP domain
DR994_RS00210	COG0436	Aminotransferase
DR994_RS00225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DR994_RS00235	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DR994_RS00250	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DR994_RS00275	COG0151	Belongs to the GarS family
DR994_RS00280	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DR994_RS00300	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DR994_RS00315	COG4550	Control of competence regulator ComK, YlbF/YmcA
DR994_RS00355	COG2818	Glycosylase
DR994_RS00360	COG1546	Belongs to the CinA family
DR994_RS00360	COG1058	Belongs to the CinA family
DR994_RS00370	COG1393	Belongs to the ArsC family
DR994_RS00430	COG2309	aminopeptidase activity
DR994_RS00445	COG0431	NADPH-dependent FMN reductase
DR994_RS00485	COG4463	regulation of RNA biosynthetic process
DR994_RS00490	COG0542	response to heat
DR994_RS00500	COG1686	Belongs to the peptidase S11 family
DR994_RS00515	COG1045	serine acetyltransferase
DR994_RS00525	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DR994_RS00545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DR994_RS00570	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DR994_RS00650	COG3830	Belongs to the UPF0237 family
DR994_RS00660	COG0588	phosphoglycerate mutase activity
DR994_RS00665	COG1876	peptidase activity
DR994_RS00700	COG0351	phosphomethylpyrimidine kinase
DR994_RS00705	COG4720	Psort location CytoplasmicMembrane, score
DR994_RS00800	COG4166	transmembrane transport
DR994_RS00815	COG0076	glutamate decarboxylase activity
DR994_RS00820	COG0531	amino acid
DR994_RS00840	COG0251	oxidation-reduction process
DR994_RS00850	COG0720	synthase
DR994_RS00900	COG1278	Cold shock
DR994_RS00910	COG3328	transposase activity
DR994_RS00915	COG2217	Heavy metal translocating P-type atpase
DR994_RS00930	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DR994_RS00935	COG0626	cystathionine gamma-synthase activity
DR994_RS00940	COG1045	serine acetyltransferase
DR994_RS00965	COG4975	Glucose uptake
DR994_RS00985	COG0803	Belongs to the bacterial solute-binding protein 9 family
DR994_RS00985	COG3443	Belongs to the bacterial solute-binding protein 9 family
DR994_RS01000	COG3942	CHAP domain
DR994_RS01000	COG1705	Flagellar rod assembly protein muramidase FlgJ
DR994_RS01015	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DR994_RS01020	COG2824	Alkylphosphonate utilization operon protein PhnA
DR994_RS01025	COG0765	amino acid transport
DR994_RS01030	COG1126	abc transporter atp-binding protein
DR994_RS01035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DR994_RS01055	COG1064	alcohol dehydrogenase
DR994_RS01060	COG2189	Belongs to the N(4) N(6)-methyltransferase family
DR994_RS01070	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DR994_RS01070	COG0519	Catalyzes the synthesis of GMP from XMP
DR994_RS01075	COG2188	Transcriptional regulator
DR994_RS01085	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DR994_RS01095	COG1827	regulation of RNA biosynthetic process
DR994_RS01105	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DR994_RS01115	COG1940	carbohydrate kinase activity
DR994_RS01120	COG0758	DNA mediated transformation
DR994_RS01125	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DR994_RS01175	COG0481	GTPase activity
DR994_RS01195	COG1396	sequence-specific DNA binding
DR994_RS01210	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DR994_RS01215	COG0010	Belongs to the arginase family
DR994_RS01225	COG0028	Belongs to the TPP enzyme family
DR994_RS01230	COG3527	Alpha-acetolactate decarboxylase
DR994_RS01260	COG1230	cation diffusion facilitator family transporter
DR994_RS01290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DR994_RS01305	COG1293	RNA-binding protein homologous to eukaryotic snRNP
DR994_RS01315	COG0047	phosphoribosylformylglycinamidine synthase activity
DR994_RS01330	COG0167	dihydroorotate dehydrogenase activity
DR994_RS01360	COG1337	RAMP superfamily
DR994_RS01365	COG1567	CRISPR-associated RAMP protein, Csm4 family
DR994_RS01380	COG0284	orotidine-5'-phosphate decarboxylase activity
DR994_RS01395	COG3104	oligopeptide transport
DR994_RS01440	COG1115	amino acid carrier protein
DR994_RS01450	COG2873	o-acetylhomoserine
DR994_RS01480	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DR994_RS01485	COG0196	riboflavin kinase activity
DR994_RS01490	COG1393	Belongs to the ArsC family
DR994_RS01500	COG0483	inositol monophosphate 1-phosphatase activity
DR994_RS01505	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
DR994_RS01505	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DR994_RS01515	COG0573	inorganic phosphate transmembrane transporter activity
DR994_RS01520	COG0581	inorganic phosphate transmembrane transporter activity
DR994_RS01535	COG0704	Plays a role in the regulation of phosphate uptake
DR994_RS01550	COG0095	Lipoate-protein ligase
DR994_RS01565	COG0058	SHG alpha-glucan phosphorylase activity
DR994_RS01570	COG1640	4-alpha-glucanotransferase
DR994_RS01575	COG1609	Transcriptional regulator
DR994_RS01600	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DR994_RS01605	COG0805	protein transport
DR994_RS01610	COG0672	)-iron permease
DR994_RS01615	COG2837	iron assimilation
DR994_RS01620	COG2822	iron ion transport
DR994_RS01625	COG4607	ABC-type enterochelin transport system periplasmic component
DR994_RS01630	COG4604	ABC transporter, ATP-binding protein
DR994_RS01635	COG4605	iron ion homeostasis
DR994_RS01640	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DR994_RS01725	COG0508	dehydrogenase complex catalyzes the overall conversion of
DR994_RS01730	COG0508	dehydrogenase complex catalyzes the overall conversion of
DR994_RS01730	COG0022	dehydrogenase e1 component
DR994_RS01735	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DR994_RS01765	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DR994_RS01770	COG4667	esterase of the alpha-beta hydrolase superfamily
DR994_RS01795	COG0628	permease
DR994_RS01805	COG0561	phosphatase activity
DR994_RS01830	COG0438	transferase activity, transferring glycosyl groups
DR994_RS01840	COG0562	UDP-galactopyranose mutase
DR994_RS01855	COG1316	TRANSCRIPTIONal
DR994_RS01880	COG1442	glycosyl transferase family 8
DR994_RS01880	COG1216	Glycosyl transferase, family 2
DR994_RS01890	COG1216	Glycosyl transferase, family 2
DR994_RS01905	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DR994_RS01925	COG1316	TRANSCRIPTIONal
DR994_RS01945	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DR994_RS01955	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DR994_RS01975	COG1573	uracil-dna glycosylase
DR994_RS02010	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DR994_RS02040	COG0681	Belongs to the peptidase S26 family
DR994_RS02050	COG0628	permease
DR994_RS02055	COG1051	belongs to the nudix hydrolase family
DR994_RS02060	COG2177	Part of the ABC transporter FtsEX involved in
DR994_RS02065	COG2884	Cell division ATP-binding protein ftsE
DR994_RS02075	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DR994_RS02105	COG2348	transferase activity, transferring amino-acyl groups
DR994_RS02115	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DR994_RS02120	COG5002	protein histidine kinase activity
DR994_RS02125	COG0745	RESPONSE REGULATOR receiver
DR994_RS02130	COG1126	abc transporter atp-binding protein
DR994_RS02135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DR994_RS02140	COG0765	amino acid transport
DR994_RS02145	COG0765	amino acid transport
DR994_RS02170	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DR994_RS02185	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DR994_RS02185	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DR994_RS02195	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DR994_RS02200	COG1956	GAF domain-containing protein
DR994_RS02205	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DR994_RS02225	COG0335	large ribosomal subunit rRNA binding
DR994_RS02230	COG0038	chloride channel
DR994_RS02240	COG0038	chloride channel
DR994_RS02245	COG0716	FMN binding
DR994_RS02305	COG0469	pyruvate kinase activity
DR994_RS02355	COG0167	dihydroorotate dehydrogenase activity
DR994_RS02365	COG0776	regulation of translation
DR994_RS02375	COG2755	lipolytic protein G-D-S-L family
DR994_RS02380	COG1307	EDD domain protein, DegV family
DR994_RS02385	COG0497	DNA recombination
DR994_RS02390	COG1438	arginine binding
DR994_RS02395	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DR994_RS02420	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DR994_RS02440	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DR994_RS02440	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DR994_RS02445	COG0300	oxidoreductase activity
DR994_RS02460	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DR994_RS02465	COG0772	Belongs to the SEDS family
DR994_RS02485	COG0647	UMP catabolic process
DR994_RS02495	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DR994_RS02525	COG1088	dTDP-glucose 4,6-dehydratase activity
DR994_RS02535	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DR994_RS02540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DR994_RS02555	COG2384	SAM-dependent methyltransferase
DR994_RS02580	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DR994_RS02585	COG3442	glutamine amidotransferase
DR994_RS02590	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DR994_RS02590	COG0392	lysyltransferase activity
DR994_RS02605	COG0488	(ABC) transporter
DR994_RS02615	COG0513	Belongs to the DEAD box helicase family
DR994_RS02645	COG0372	Belongs to the citrate synthase family
DR994_RS02650	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DR994_RS02655	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DR994_RS02660	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DR994_RS02665	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DR994_RS02695	COG3764	Sortase (surface protein transpeptidase)
DR994_RS02715	COG0488	(ABC) transporter
DR994_RS02740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DR994_RS02745	COG1328	CTP reductase activity
DR994_RS02745	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DR994_RS02770	COG1196	nuclear chromosome segregation
DR994_RS02785	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DR994_RS02800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DR994_RS02810	COG1011	Hydrolase
DR994_RS02815	COG1268	BioY protein
DR994_RS02825	COG0517	IMP dehydrogenase activity
DR994_RS02825	COG1125	glycine betaine transport
DR994_RS02840	COG2986	histidine ammonia-lyase
DR994_RS02850	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DR994_RS02855	COG1760	l-serine dehydratase
DR994_RS02860	COG1760	l-serine dehydratase
DR994_RS02885	COG2197	response regulator
DR994_RS02890	COG4585	Histidine kinase
DR994_RS02900	COG1131	(ABC) transporter
DR994_RS02915	COG0385	Bile acid
DR994_RS02975	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DR994_RS03010	COG0577	efflux transmembrane transporter activity
DR994_RS03015	COG1136	(ABC) transporter
DR994_RS03020	COG0784	Response regulator, receiver
DR994_RS03020	COG2198	Histidine kinase
DR994_RS03020	COG5002	protein histidine kinase activity
DR994_RS03025	COG0745	RESPONSE REGULATOR receiver
DR994_RS03040	COG0534	Mate efflux family protein
DR994_RS03045	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DR994_RS03045	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DR994_RS03060	COG1126	abc transporter atp-binding protein
DR994_RS03065	COG0765	amino acid transport
DR994_RS03075	COG2079	MmgE PrpD family protein
DR994_RS03080	COG0436	Aminotransferase
DR994_RS03090	COG1473	amidohydrolase
DR994_RS03110	COG0531	amino acid
DR994_RS03125	COG1959	2 iron, 2 sulfur cluster binding
DR994_RS03135	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DR994_RS03140	COG0778	Nitroreductase
DR994_RS03150	COG0656	L-ascorbic acid biosynthetic process
DR994_RS03200	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DR994_RS03225	COG1280	lysine exporter protein (LysE YggA)
DR994_RS03235	COG1442	glycosyl transferase family 8
DR994_RS03235	COG1216	Glycosyl transferase, family 2
DR994_RS03240	COG0577	efflux transmembrane transporter activity
DR994_RS03295	COG1396	sequence-specific DNA binding
DR994_RS03315	COG0419	ATPase involved in DNA repair
DR994_RS03320	COG0420	3'-5' exonuclease activity
DR994_RS03330	COG3250	beta-galactosidase activity
DR994_RS03335	COG2211	Major facilitator Superfamily
DR994_RS03335	COG2190	(PTS) system
DR994_RS03340	COG2017	converts alpha-aldose to the beta-anomer
DR994_RS03345	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DR994_RS03360	COG1609	Transcriptional regulator
DR994_RS03380	COG0488	(ABC) transporter
DR994_RS03415	COG0436	Aminotransferase
DR994_RS03425	COG1199	ATP-dependent helicase activity
DR994_RS03425	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DR994_RS03450	COG1744	ABC transporter substrate-binding protein PnrA-like
DR994_RS03455	COG0295	cytidine deaminase activity
DR994_RS03470	COG2813	Specifically methylates the guanine in position
DR994_RS03495	COG5002	protein histidine kinase activity
DR994_RS03520	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DR994_RS03525	COG4684	Psort location CytoplasmicMembrane, score
DR994_RS03530	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DR994_RS03550	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DR994_RS03555	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DR994_RS03565	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DR994_RS03575	COG1696	Membrane protein involved in D-alanine export
DR994_RS03590	COG1132	(ABC) transporter
DR994_RS03620	COG2890	protein-(glutamine-N5) methyltransferase activity
DR994_RS03630	COG1435	thymidine kinase activity
DR994_RS03635	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DR994_RS03645	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DR994_RS03675	COG3599	regulation of cell shape
DR994_RS03700	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DR994_RS03710	COG0849	cell division
DR994_RS03740	COG1940	carbohydrate kinase activity
DR994_RS03745	COG4483	Protein conserved in bacteria
DR994_RS03750	COG0735	belongs to the Fur family
DR994_RS03755	COG0783	Belongs to the Dps family
DR994_RS03760	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DR994_RS03770	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DR994_RS03780	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DR994_RS03795	COG0501	Belongs to the peptidase M48B family
DR994_RS03800	COG1704	LemA family
DR994_RS03840	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DR994_RS03885	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DR994_RS03890	COG0406	alpha-ribazole phosphatase activity
DR994_RS03945	COG1914	H( )-stimulated, divalent metal cation uptake system
DR994_RS03950	COG4443	Transcriptional Coactivator p15 (PC4)
DR994_RS03960	COG1268	BioY protein
DR994_RS03995	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DR994_RS04015	COG2183	response to ionizing radiation
DR994_RS04020	COG0701	Predicted permease
DR994_RS04025	COG3689	TIGRFAM TIGR03943 family protein
DR994_RS04035	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
DR994_RS04040	COG1518	maintenance of DNA repeat elements
DR994_RS04115	COG2274	protein secretion by the type I secretion system
DR994_RS04120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DR994_RS04150	COG3843	relaxase mobilization nuclease domain protein
DR994_RS04220	COG1131	(ABC) transporter
DR994_RS04230	COG1994	Peptidase M50
DR994_RS04235	COG0535	radical SAM domain protein
DR994_RS04240	COG3328	transposase activity
DR994_RS04340	COG0270	DNA (cytosine-5-)-methyltransferase activity
DR994_RS04380	COG0077	Prephenate dehydratase
DR994_RS04405	COG0287	Prephenate dehydrogenase
DR994_RS04430	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DR994_RS04435	COG1368	sulfuric ester hydrolase activity
DR994_RS04470	COG1609	Transcriptional regulator
DR994_RS04475	COG0006	proline dipeptidase activity
DR994_RS04480	COG1185	polyribonucleotide nucleotidyltransferase activity
DR994_RS04495	COG0557	exoribonuclease II activity
DR994_RS04510	COG2814	Major facilitator Superfamily
DR994_RS04515	COG0237	dephospho-CoA kinase activity
DR994_RS04520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DR994_RS04550	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DR994_RS04555	COG0768	penicillin binding
DR994_RS04560	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DR994_RS04565	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DR994_RS04615	COG4703	Protein of unknown function (DUF1797)
DR994_RS04620	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DR994_RS04625	COG0542	response to heat
DR994_RS04630	COG0494	nUDIX hydrolase
DR994_RS04670	COG0539	negative regulation of cytoplasmic translation
DR994_RS04690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DR994_RS04700	COG0187	DNA topoisomerase II activity
DR994_RS04720	COG2040	homocysteine
DR994_RS04725	COG0833	amino acid
DR994_RS04745	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DR994_RS04755	COG3425	synthase
DR994_RS04770	COG1272	protein, Hemolysin III
DR994_RS04805	COG0438	transferase activity, transferring glycosyl groups
DR994_RS04875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DR994_RS04880	COG0686	Belongs to the AlaDH PNT family
DR994_RS04885	COG0686	Belongs to the AlaDH PNT family
DR994_RS04890	COG1473	amidohydrolase
DR994_RS04895	COG1187	pseudouridine synthase activity
DR994_RS04930	COG1131	(ABC) transporter
DR994_RS04940	COG3279	Response regulator of the LytR AlgR family
DR994_RS04955	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DR994_RS04980	COG0577	efflux transmembrane transporter activity
DR994_RS04985	COG0577	efflux transmembrane transporter activity
DR994_RS05020	COG0505	Belongs to the CarA family
DR994_RS05040	COG0564	pseudouridine synthase activity
DR994_RS05050	COG0583	DNA-binding transcription factor activity
DR994_RS05090	COG1113	amino acid transport
DR994_RS05135	COG1705	Flagellar rod assembly protein muramidase FlgJ
DR994_RS05135	COG1388	LysM domain
DR994_RS05140	COG0347	Belongs to the P(II) protein family
DR994_RS05145	COG0004	ammonium transporteR
DR994_RS05155	COG4467	Involved in initiation control of chromosome replication
DR994_RS05160	COG1774	PSP1 C-terminal conserved region
DR994_RS05165	COG0470	DNA polymerase III
DR994_RS05185	COG0772	Belongs to the SEDS family
DR994_RS05220	COG0356	it plays a direct role in the translocation of protons across the membrane
DR994_RS05255	COG2962	Rard protein
DR994_RS05275	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DR994_RS05280	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DR994_RS05295	COG0436	Aminotransferase
DR994_RS05300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DR994_RS05320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DR994_RS05325	COG4122	O-methyltransferase activity
DR994_RS05345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DR994_RS05345	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DR994_RS05370	COG1702	phosphate starvation-inducible protein PhoH
DR994_RS05430	COG0242	peptide deformylase activity
DR994_RS05435	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DR994_RS05455	COG0488	(ABC) transporter
DR994_RS05520	COG1104	cysteine desulfurase activity
DR994_RS05530	COG0285	dihydrofolate synthase activity
DR994_RS05535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DR994_RS05545	COG1105	Belongs to the carbohydrate kinase PfkB family
DR994_RS05550	COG1349	DNA-binding transcription factor activity
DR994_RS05590	COG0439	Biotin carboxylase
DR994_RS05605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DR994_RS05610	COG1028	Short-chain dehydrogenase reductase Sdr
DR994_RS05615	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DR994_RS05635	COG1846	Transcriptional regulator
DR994_RS05640	COG1024	Enoyl-CoA hydratase
DR994_RS05645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DR994_RS05650	COG0527	aspartate kinase activity
DR994_RS05655	COG2502	aspartate--ammonia ligase
DR994_RS05740	COG1040	competence protein
DR994_RS05745	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DR994_RS05750	COG1739	Uncharacterized protein family UPF0029
DR994_RS05780	COG0559	Belongs to the binding-protein-dependent transport system permease family
DR994_RS05790	COG4471	UPF0298 protein
DR994_RS05815	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DR994_RS05820	COG0626	cystathionine gamma-synthase activity
DR994_RS05825	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DR994_RS05830	COG2244	polysaccharide biosynthetic process
DR994_RS05865	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DR994_RS05870	COG0195	Participates in both transcription termination and antitermination
DR994_RS05880	COG1316	TRANSCRIPTIONal
DR994_RS05885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DR994_RS05890	COG0802	atpase or kinase
DR994_RS05895	COG2252	PERMEase
DR994_RS05900	COG0561	phosphatase activity
DR994_RS05905	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DR994_RS05915	COG3715	PTS system
DR994_RS05920	COG3716	PTS system mannose fructose sorbose family IID component
DR994_RS05955	COG1484	DNA-dependent DNA replication
DR994_RS05970	COG5002	protein histidine kinase activity
DR994_RS05975	COG0745	RESPONSE REGULATOR receiver
DR994_RS05990	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DR994_RS06000	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DR994_RS06010	COG1122	ATPase activity
DR994_RS06025	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
DR994_RS06045	COG1464	Belongs to the NlpA lipoprotein family
DR994_RS06050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DR994_RS06055	COG1122	ATPase activity
DR994_RS06065	COG0310	cobalt ion transport
DR994_RS06070	COG0829	nickel cation binding
DR994_RS06120	COG2274	protein secretion by the type I secretion system
DR994_RS06130	COG2274	protein secretion by the type I secretion system
DR994_RS06135	COG2274	protein secretion by the type I secretion system
DR994_RS06150	COG0671	phosphoesterase, PA-phosphatase related
DR994_RS06155	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DR994_RS06165	COG0569	domain protein
DR994_RS06170	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DR994_RS06180	COG1187	pseudouridine synthase activity
DR994_RS06185	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DR994_RS06190	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DR994_RS06210	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DR994_RS06255	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DR994_RS06260	COG1254	Belongs to the acylphosphatase family
DR994_RS06280	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DR994_RS06300	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DR994_RS06310	COG0116	Belongs to the methyltransferase superfamily
DR994_RS06335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DR994_RS06340	COG3579	cysteine-type endopeptidase activity
DR994_RS06355	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DR994_RS06375	COG1349	DNA-binding transcription factor activity
DR994_RS06405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DR994_RS06410	COG0564	pseudouridine synthase activity
DR994_RS06445	COG1116	anion transmembrane transporter activity
DR994_RS06445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DR994_RS06450	COG4120	Belongs to the binding-protein-dependent transport system permease family
DR994_RS06465	COG4589	Belongs to the CDS family
DR994_RS06505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DR994_RS06510	COG1121	(ABC) transporter
DR994_RS06535	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DR994_RS06550	COG4608	Belongs to the ABC transporter superfamily
DR994_RS06575	COG0719	Fe-S assembly protein
DR994_RS06585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DR994_RS06590	COG0719	Fe-S assembly protein
DR994_RS06600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DR994_RS06605	COG4862	establishment of competence for transformation
DR994_RS06615	COG1968	undecaprenyl-diphosphatase activity
DR994_RS06620	COG0765	amino acid transport
DR994_RS06625	COG1126	abc transporter atp-binding protein
DR994_RS06665	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DR994_RS06705	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DR994_RS06715	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DR994_RS06725	COG0504	CTP synthase activity
DR994_RS06740	COG0668	transmembrane transport
DR994_RS06760	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DR994_RS06815	COG2197	response regulator
DR994_RS06820	COG4585	Histidine kinase
DR994_RS06835	COG2815	serine threonine protein kinase
DR994_RS06835	COG0515	serine threonine protein kinase
DR994_RS06845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DR994_RS06845	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DR994_RS06855	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DR994_RS06870	COG0552	protein localization to endoplasmic reticulum
DR994_RS06875	COG0561	phosphatase activity
DR994_RS06880	COG0561	phosphatase activity
DR994_RS06885	COG1725	Transcriptional regulator
DR994_RS06890	COG1131	(ABC) transporter
DR994_RS06900	COG4608	Belongs to the ABC transporter superfamily
DR994_RS06905	COG0444	Belongs to the ABC transporter superfamily
DR994_RS06910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DR994_RS06915	COG0601	transmembrane transport
DR994_RS06930	COG4608	Belongs to the ABC transporter superfamily
DR994_RS06935	COG4608	Belongs to the ABC transporter superfamily
DR994_RS06945	COG2223	nitrite transmembrane transporter activity
DR994_RS06955	COG0280	phosphate acetyltransferase
DR994_RS06960	COG0564	pseudouridine synthase activity
DR994_RS06970	COG2357	RelA SpoT domain protein
DR994_RS06985	COG1104	cysteine desulfurase activity
DR994_RS07000	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DR994_RS07005	COG2003	Belongs to the UPF0758 family
DR994_RS07030	COG1215	transferase activity, transferring glycosyl groups
DR994_RS07040	COG1216	Glycosyl transferase, family 2
DR994_RS07040	COG1442	glycosyl transferase family 8
DR994_RS07060	COG1091	dTDP-4-dehydrorhamnose reductase activity
DR994_RS07070	COG0463	Glycosyl transferase, family 2
DR994_RS07080	COG2151	metal-sulfur cluster biosynthetic enzyme
DR994_RS07085	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DR994_RS07090	COG0358	DNA primase activity
DR994_RS07105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DR994_RS07110	COG0436	Aminotransferase
DR994_RS07115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DR994_RS07120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DR994_RS07125	COG1051	belongs to the nudix hydrolase family
DR994_RS07145	COG0765	amino acid transport
DR994_RS07150	COG1126	abc transporter atp-binding protein
DR994_RS07170	COG1187	pseudouridine synthase activity
DR994_RS07215	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
DR994_RS07220	COG1518	maintenance of DNA repeat elements
DR994_RS07230	COG0560	Phosphoserine phosphatase
DR994_RS07240	COG0187	DNA topoisomerase II activity
DR994_RS07250	COG1346	cytolysis
DR994_RS07255	COG1380	Effector of murein hydrolase LrgA
DR994_RS07265	COG1393	Belongs to the ArsC family
DR994_RS07275	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DR994_RS07295	COG0346	lactoylglutathione lyase activity
DR994_RS07310	COG1177	transmembrane transport
DR994_RS07315	COG1176	ABC-type spermidine putrescine transport system, permease component I
DR994_RS07355	COG0531	amino acid
DR994_RS07360	COG0285	dihydrofolate synthase activity
DR994_RS07365	COG1837	Belongs to the UPF0109 family
DR994_RS07375	COG3615	Tellurite resistance protein tehB
DR994_RS07375	COG0500	methyltransferase
DR994_RS07385	COG0708	Exodeoxyribonuclease III
DR994_RS07400	COG1597	lipid kinase activity
DR994_RS07410	COG4708	membrane
DR994_RS07420	COG0024	Methionine aminopeptidase
DR994_RS07425	COG4109	DRTGG domain
DR994_RS07435	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DR994_RS07440	COG0658	competence protein
DR994_RS07440	COG2333	competence protein COMEC
DR994_RS07445	COG1555	photosystem II stabilization
DR994_RS07445	COG1596	polysaccharide export
DR994_RS07450	COG0204	Acyl-transferase
DR994_RS07460	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DR994_RS07470	COG0513	Belongs to the DEAD box helicase family
DR994_RS07490	COG1396	sequence-specific DNA binding
DR994_RS07495	COG2211	Major facilitator Superfamily
DR994_RS07510	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DR994_RS07520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DR994_RS07525	COG1126	abc transporter atp-binding protein
DR994_RS07530	COG0765	amino acid transport
DR994_RS07540	COG1181	Belongs to the D-alanine--D-alanine ligase family
DR994_RS07550	COG2217	Heavy metal translocating P-type atpase
DR994_RS07570	COG0135	phosphoribosylanthranilate isomerase activity
DR994_RS07585	COG0512	Glutamine amidotransferase of anthranilate synthase
DR994_RS07590	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DR994_RS07595	COG0287	Prephenate dehydrogenase
DR994_RS07595	COG1605	Chorismate mutase
DR994_RS07605	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DR994_RS07630	COG2176	DNA-directed DNA polymerase activity
DR994_RS07640	COG2151	metal-sulfur cluster biosynthetic enzyme
DR994_RS07650	COG2081	HI0933 family
DR994_RS07675	COG1131	(ABC) transporter
DR994_RS07680	COG0537	adenosine 5'-monophosphoramidase activity
DR994_RS07715	COG2226	methyltransferase
DR994_RS07720	COG0799	negative regulation of ribosome biogenesis
DR994_RS07725	COG1713	HD superfamily hydrolase involved in NAD metabolism
DR994_RS07730	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DR994_RS07735	COG1534	Rna-binding protein
DR994_RS07740	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DR994_RS07745	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DR994_RS07785	COG2723	6-phospho-beta-galactosidase activity
DR994_RS07800	COG1335	isochorismatase
DR994_RS07810	COG0436	Aminotransferase
DR994_RS07815	COG0589	response to stress
DR994_RS07835	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DR994_RS07845	COG1253	flavin adenine dinucleotide binding
DR994_RS07850	COG1119	ATPase activity
DR994_RS07855	COG0025	NhaP-type Na H and K H
DR994_RS07865	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DR994_RS07870	COG1242	4 iron, 4 sulfur cluster binding
DR994_RS07875	COG3480	Lon protease (S16) C-terminal proteolytic domain
DR994_RS07880	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DR994_RS07885	COG0742	ribosomal rna small subunit methyltransferase
DR994_RS07890	COG0492	ferredoxin-NADP+ reductase activity
DR994_RS07900	COG1126	abc transporter atp-binding protein
DR994_RS07910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DR994_RS07925	COG1882	Formate acetyltransferase
DR994_RS07960	COG0390	transport system, permease component
DR994_RS07965	COG4619	ABC transporter
DR994_RS07970	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DR994_RS07985	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DR994_RS08005	COG3328	transposase activity
DR994_RS08015	COG1132	(ABC) transporter
DR994_RS08020	COG1132	(ABC) transporter
DR994_RS08040	COG4470	Protein conserved in bacteria
DR994_RS08045	COG0737	Belongs to the 5'-nucleotidase family
DR994_RS08050	COG0513	Belongs to the DEAD box helicase family
DR994_RS08060	COG0768	penicillin binding
DR994_RS08090	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DR994_RS08105	COG1131	(ABC) transporter
DR994_RS08120	COG1074	ATP-dependent DNA helicase activity
DR994_RS08125	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DR994_RS08160	COG0561	phosphatase activity
DR994_RS08165	COG0252	asparaginase activity
DR994_RS08170	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DR994_RS08175	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DR994_RS08185	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DR994_RS08190	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DR994_RS08205	COG1482	cell wall glycoprotein biosynthetic process
DR994_RS08210	COG1940	carbohydrate kinase activity
DR994_RS08215	COG1263	PTS System
DR994_RS08215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DR994_RS08215	COG2190	(PTS) system
DR994_RS08220	COG1621	beta-fructofuranosidase activity
DR994_RS08225	COG1609	Transcriptional regulator
DR994_RS08245	COG2131	deaminase
DR994_RS08250	COG0006	proline dipeptidase activity
DR994_RS08265	COG1131	(ABC) transporter
DR994_RS08340	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DR994_RS08340	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DR994_RS08345	COG1193	negative regulation of DNA recombination
DR994_RS08365	COG0681	Belongs to the peptidase S26 family
DR994_RS08370	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DR994_RS08380	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DR994_RS08390	COG0456	acetyltransferase
DR994_RS08395	COG1214	PFAM Peptidase M22, glycoprotease
DR994_RS08415	COG0174	glutamine synthetase
DR994_RS08420	COG0789	Transcriptional regulator
DR994_RS08470	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DR994_RS08515	COG0084	hydrolase, TatD family'
DR994_RS08520	COG1832	CoA-binding protein
DR994_RS08525	COG3118	belongs to the thioredoxin family
DR994_RS08590	COG0706	membrane insertase activity
DR994_RS08650	COG0756	dUTP diphosphatase activity
DR994_RS08685	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DR994_RS08690	COG0705	Rhomboid family
DR994_RS08690	COG0457	Tetratricopeptide repeat
DR994_RS08695	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DR994_RS08715	COG2226	methyltransferase
DR994_RS08740	COG0425	Belongs to the sulfur carrier protein TusA family
DR994_RS08745	COG2391	methyltransferase activity
DR994_RS08750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DR994_RS08755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DR994_RS08765	COG1363	Peptidase, m42
DR994_RS08770	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DR994_RS08775	COG1266	CAAX protease self-immunity
DR994_RS08830	COG1459	type II secretion system
DR994_RS08835	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DR994_RS08870	COG0440	acetolactate synthase activity
DR994_RS08875	COG0028	Belongs to the TPP enzyme family
DR994_RS08885	COG1461	Dihydroxyacetone kinase
DR994_RS08895	COG0534	Mate efflux family protein
DR994_RS08910	COG1012	belongs to the aldehyde dehydrogenase family
DR994_RS08910	COG1454	alcohol dehydrogenase
DR994_RS08915	COG1454	alcohol dehydrogenase
DR994_RS08915	COG1012	belongs to the aldehyde dehydrogenase family
DR994_RS08920	COG1454	alcohol dehydrogenase
DR994_RS08920	COG1012	belongs to the aldehyde dehydrogenase family
DR994_RS08930	COG1012	belongs to the aldehyde dehydrogenase family
DR994_RS08930	COG1454	alcohol dehydrogenase
DR994_RS08935	COG3590	peptidase
DR994_RS08940	COG0366	Alpha amylase catalytic
DR994_RS08945	COG0366	Alpha amylase catalytic
DR994_RS08950	COG0366	Alpha amylase catalytic
DR994_RS08965	COG1609	Transcriptional regulator
DR994_RS08970	COG2188	Transcriptional regulator
DR994_RS08975	COG4475	Protein of unknown function (DUF436)
DR994_RS08995	COG0191	fructose-bisphosphate aldolase activity
DR994_RS09060	COG0201	protein transport
DR994_RS09205	COG3328	transposase activity
DR994_RS09215	COG0515	serine threonine protein kinase
DR994_RS09220	COG1132	(ABC) transporter
DR994_RS09225	COG1396	sequence-specific DNA binding
DR994_RS09230	COG1396	sequence-specific DNA binding
DR994_RS09240	COG1132	(ABC) transporter
DR994_RS09270	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DR994_RS09300	COG1328	CTP reductase activity
DR994_RS09310	COG0602	queuosine metabolic process
DR994_RS09315	COG3022	response to hydroperoxide
DR994_RS09320	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DR994_RS09340	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DR994_RS09355	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DR994_RS09365	COG1002	Type II restriction enzyme, methylase subunits
DR994_RS09395	COG0582	viral genome integration into host DNA
DR994_RS09420	COG2261	transglycosylase associated protein
DR994_RS09440	COG3237	CsbD-like
DR994_RS09445	COG0494	nUDIX hydrolase
DR994_RS09465	COG1511	domain protein
DR994_RS09465	COG1511	domain protein
DR994_RS09475	COG3759	membrane
DR994_RS09495	COG0305	Participates in initiation and elongation during chromosome replication
DR994_RS09515	COG0494	nUDIX hydrolase
DR994_RS09530	COG0741	lytic transglycosylase activity
DR994_RS09535	COG3584	3D domain protein
DR994_RS09535	COG1388	LysM domain
DR994_RS09540	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DR994_RS09555	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DR994_RS09565	COG0612	Peptidase, M16
DR994_RS09595	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DR994_RS09600	COG0488	(ABC) transporter
DR994_RS09635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DR994_RS09640	COG1475	DNA binding