locus-tag	class	description
CW339_RS00010	COG0592	DNA-directed DNA polymerase activity
CW339_RS00020	COG0012	GTP binding
CW339_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CW339_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CW339_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CW339_RS00185	COG3942	CHAP domain
CW339_RS00200	COG0436	Aminotransferase
CW339_RS00215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CW339_RS00225	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CW339_RS00240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CW339_RS00255	COG1388	LysM domain
CW339_RS00255	COG3942	CHAP domain
CW339_RS00260	COG0151	Belongs to the GarS family
CW339_RS00265	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CW339_RS00285	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CW339_RS00300	COG4550	Control of competence regulator ComK, YlbF/YmcA
CW339_RS00340	COG2818	Glycosylase
CW339_RS00355	COG1393	Belongs to the ArsC family
CW339_RS00450	COG2309	aminopeptidase activity
CW339_RS00505	COG4463	regulation of RNA biosynthetic process
CW339_RS00510	COG0542	response to heat
CW339_RS00520	COG1686	Belongs to the peptidase S11 family
CW339_RS00535	COG1045	serine acetyltransferase
CW339_RS00545	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CW339_RS00560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CW339_RS00585	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CW339_RS00665	COG3830	Belongs to the UPF0237 family
CW339_RS00680	COG1876	peptidase activity
CW339_RS00715	COG0351	phosphomethylpyrimidine kinase
CW339_RS00720	COG4720	Psort location CytoplasmicMembrane, score
CW339_RS00760	COG1473	amidohydrolase
CW339_RS00765	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CW339_RS00785	COG0668	transmembrane transport
CW339_RS00800	COG0504	CTP synthase activity
CW339_RS00810	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CW339_RS00820	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CW339_RS00825	COG0737	Belongs to the 5'-nucleotidase family
CW339_RS00860	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CW339_RS00895	COG1126	abc transporter atp-binding protein
CW339_RS00900	COG0765	amino acid transport
CW339_RS00920	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CW339_RS00930	COG0719	Fe-S assembly protein
CW339_RS00935	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CW339_RS00945	COG0719	Fe-S assembly protein
CW339_RS00985	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CW339_RS01000	COG1121	(ABC) transporter
CW339_RS01005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CW339_RS01045	COG4589	Belongs to the CDS family
CW339_RS01060	COG4120	Belongs to the binding-protein-dependent transport system permease family
CW339_RS01065	COG1116	anion transmembrane transporter activity
CW339_RS01065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CW339_RS01100	COG0564	pseudouridine synthase activity
CW339_RS01105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CW339_RS01135	COG1349	DNA-binding transcription factor activity
CW339_RS01165	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CW339_RS01180	COG3579	cysteine-type endopeptidase activity
CW339_RS01185	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CW339_RS01210	COG0116	Belongs to the methyltransferase superfamily
CW339_RS01220	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CW339_RS01240	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CW339_RS01265	COG1254	Belongs to the acylphosphatase family
CW339_RS01270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CW339_RS01315	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CW339_RS01335	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CW339_RS01340	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CW339_RS01345	COG1187	pseudouridine synthase activity
CW339_RS01355	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CW339_RS01360	COG0569	domain protein
CW339_RS01370	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CW339_RS01375	COG0671	phosphoesterase, PA-phosphatase related
CW339_RS01390	COG2274	protein secretion by the type I secretion system
CW339_RS01395	COG2274	protein secretion by the type I secretion system
CW339_RS01400	COG2274	protein secretion by the type I secretion system
CW339_RS01405	COG2274	protein secretion by the type I secretion system
CW339_RS01465	COG0829	nickel cation binding
CW339_RS01470	COG0310	cobalt ion transport
CW339_RS01480	COG1122	ATPase activity
CW339_RS01485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CW339_RS01490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CW339_RS01510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CW339_RS01515	COG1464	Belongs to the NlpA lipoprotein family
CW339_RS01525	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CW339_RS01550	COG1122	ATPase activity
CW339_RS01560	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CW339_RS01575	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CW339_RS01590	COG0745	RESPONSE REGULATOR receiver
CW339_RS01595	COG5002	protein histidine kinase activity
CW339_RS01610	COG1484	DNA-dependent DNA replication
CW339_RS01650	COG3716	PTS system mannose fructose sorbose family IID component
CW339_RS01655	COG3715	PTS system
CW339_RS01665	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CW339_RS01670	COG0561	phosphatase activity
CW339_RS01675	COG2252	PERMEase
CW339_RS01680	COG0802	atpase or kinase
CW339_RS01685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CW339_RS01690	COG1316	TRANSCRIPTIONal
CW339_RS01700	COG0195	Participates in both transcription termination and antitermination
CW339_RS01705	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CW339_RS01725	COG1611	Belongs to the LOG family
CW339_RS01745	COG2244	polysaccharide biosynthetic process
CW339_RS01750	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CW339_RS01755	COG0626	cystathionine gamma-synthase activity
CW339_RS01760	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CW339_RS01790	COG4471	UPF0298 protein
CW339_RS01800	COG0559	Belongs to the binding-protein-dependent transport system permease family
CW339_RS01830	COG1739	Uncharacterized protein family UPF0029
CW339_RS01835	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CW339_RS01840	COG1040	competence protein
CW339_RS01930	COG0527	aspartate kinase activity
CW339_RS01935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CW339_RS01940	COG1024	Enoyl-CoA hydratase
CW339_RS01945	COG1846	Transcriptional regulator
CW339_RS01965	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CW339_RS01970	COG1028	Short-chain dehydrogenase reductase Sdr
CW339_RS01975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CW339_RS01990	COG0439	Biotin carboxylase
CW339_RS02030	COG1349	DNA-binding transcription factor activity
CW339_RS02035	COG1105	Belongs to the carbohydrate kinase PfkB family
CW339_RS02045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CW339_RS02050	COG0285	dihydrofolate synthase activity
CW339_RS02060	COG1104	cysteine desulfurase activity
CW339_RS02120	COG0488	(ABC) transporter
CW339_RS02140	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CW339_RS02145	COG0242	peptide deformylase activity
CW339_RS02205	COG1702	phosphate starvation-inducible protein PhoH
CW339_RS02225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CW339_RS02225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CW339_RS02255	COG4122	O-methyltransferase activity
CW339_RS02260	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CW339_RS02295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CW339_RS02300	COG0436	Aminotransferase
CW339_RS02315	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CW339_RS02320	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CW339_RS02325	COG0726	polysaccharide deacetylase
CW339_RS02340	COG2962	Rard protein
CW339_RS02380	COG0356	it plays a direct role in the translocation of protons across the membrane
CW339_RS02415	COG0772	Belongs to the SEDS family
CW339_RS02435	COG0470	DNA polymerase III
CW339_RS02440	COG1774	PSP1 C-terminal conserved region
CW339_RS02445	COG4467	Involved in initiation control of chromosome replication
CW339_RS02455	COG0004	ammonium transporteR
CW339_RS02460	COG0347	Belongs to the P(II) protein family
CW339_RS02465	COG1388	LysM domain
CW339_RS02465	COG1705	Flagellar rod assembly protein muramidase FlgJ
CW339_RS02515	COG1113	amino acid transport
CW339_RS02525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CW339_RS02525	COG1263	PTS System
CW339_RS02525	COG2190	(PTS) system
CW339_RS02530	COG2190	(PTS) system
CW339_RS02530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CW339_RS02530	COG1263	PTS System
CW339_RS02570	COG0583	DNA-binding transcription factor activity
CW339_RS02580	COG0564	pseudouridine synthase activity
CW339_RS02600	COG0505	Belongs to the CarA family
CW339_RS02640	COG0577	efflux transmembrane transporter activity
CW339_RS02645	COG0577	efflux transmembrane transporter activity
CW339_RS02740	COG3279	Response regulator of the LytR AlgR family
CW339_RS02750	COG1131	(ABC) transporter
CW339_RS02785	COG1187	pseudouridine synthase activity
CW339_RS02790	COG1473	amidohydrolase
CW339_RS02795	COG0686	Belongs to the AlaDH PNT family
CW339_RS02800	COG0686	Belongs to the AlaDH PNT family
CW339_RS02810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CW339_RS02875	COG0438	transferase activity, transferring glycosyl groups
CW339_RS02910	COG1272	protein, Hemolysin III
CW339_RS02925	COG3425	synthase
CW339_RS02935	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CW339_RS02955	COG0833	amino acid
CW339_RS02960	COG2040	homocysteine
CW339_RS02980	COG0187	DNA topoisomerase II activity
CW339_RS02990	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CW339_RS03010	COG0539	negative regulation of cytoplasmic translation
CW339_RS03050	COG0494	nUDIX hydrolase
CW339_RS03055	COG0542	response to heat
CW339_RS03060	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CW339_RS03065	COG4703	Protein of unknown function (DUF1797)
CW339_RS03070	COG0765	amino acid transport
CW339_RS03125	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CW339_RS03130	COG0768	penicillin binding
CW339_RS03135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CW339_RS03150	COG3711	transcriptional antiterminator
CW339_RS03160	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CW339_RS03165	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CW339_RS03170	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CW339_RS03175	COG0237	dephospho-CoA kinase activity
CW339_RS03195	COG0557	exoribonuclease II activity
CW339_RS03210	COG1185	polyribonucleotide nucleotidyltransferase activity
CW339_RS03215	COG0006	proline dipeptidase activity
CW339_RS03220	COG1609	Transcriptional regulator
CW339_RS03255	COG1368	sulfuric ester hydrolase activity
CW339_RS03260	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CW339_RS03285	COG0287	Prephenate dehydrogenase
CW339_RS03310	COG0077	Prephenate dehydratase
CW339_RS03430	COG1518	maintenance of DNA repeat elements
CW339_RS03435	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CW339_RS03445	COG3689	TIGRFAM TIGR03943 family protein
CW339_RS03450	COG0701	Predicted permease
CW339_RS03455	COG2183	response to ionizing radiation
CW339_RS03500	COG0826	peptidase U32
CW339_RS03515	COG1268	BioY protein
CW339_RS03525	COG4443	Transcriptional Coactivator p15 (PC4)
CW339_RS03535	COG1914	H( )-stimulated, divalent metal cation uptake system
CW339_RS03545	COG0494	nUDIX hydrolase
CW339_RS03555	COG3328	transposase activity
CW339_RS03565	COG1388	LysM domain
CW339_RS03565	COG1705	Flagellar rod assembly protein muramidase FlgJ
CW339_RS03585	COG0406	alpha-ribazole phosphatase activity
CW339_RS03590	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CW339_RS03630	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CW339_RS03685	COG1704	LemA family
CW339_RS03715	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CW339_RS03725	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CW339_RS03730	COG0783	Belongs to the Dps family
CW339_RS03735	COG0735	belongs to the Fur family
CW339_RS03740	COG4483	Protein conserved in bacteria
CW339_RS03745	COG1940	carbohydrate kinase activity
CW339_RS03750	COG1217	gtp-binding protein TYPA
CW339_RS03775	COG0849	cell division
CW339_RS03785	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CW339_RS03810	COG3599	regulation of cell shape
CW339_RS03845	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CW339_RS03850	COG0625	glutathione transferase activity
CW339_RS03860	COG1435	thymidine kinase activity
CW339_RS03870	COG2890	protein-(glutamine-N5) methyltransferase activity
CW339_RS03900	COG1132	(ABC) transporter
CW339_RS03915	COG1696	Membrane protein involved in D-alanine export
CW339_RS03925	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CW339_RS03935	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CW339_RS03940	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CW339_RS04000	COG1396	sequence-specific DNA binding
CW339_RS04005	COG0582	viral genome integration into host DNA
CW339_RS04025	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CW339_RS04030	COG4684	Psort location CytoplasmicMembrane, score
CW339_RS04035	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CW339_RS04060	COG5002	protein histidine kinase activity
CW339_RS04065	COG5002	protein histidine kinase activity
CW339_RS04070	COG5002	protein histidine kinase activity
CW339_RS04095	COG0038	chloride channel
CW339_RS04130	COG2813	Specifically methylates the guanine in position
CW339_RS04150	COG0295	cytidine deaminase activity
CW339_RS04155	COG1744	ABC transporter substrate-binding protein PnrA-like
CW339_RS04160	COG3845	ABC transporter
CW339_RS04165	COG4603	Belongs to the binding-protein-dependent transport system permease family
CW339_RS04170	COG1079	Belongs to the binding-protein-dependent transport system permease family
CW339_RS04180	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CW339_RS04180	COG1199	ATP-dependent helicase activity
CW339_RS04190	COG0436	Aminotransferase
CW339_RS04210	COG0251	oxidation-reduction process
CW339_RS04220	COG0720	synthase
CW339_RS04275	COG1278	Cold shock
CW339_RS04290	COG3328	transposase activity
CW339_RS04295	COG2217	Heavy metal translocating P-type atpase
CW339_RS04300	COG3328	transposase activity
CW339_RS04315	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CW339_RS04320	COG0626	cystathionine gamma-synthase activity
CW339_RS04335	COG3328	transposase activity
CW339_RS04345	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CW339_RS04355	COG4975	Glucose uptake
CW339_RS04380	COG3443	Belongs to the bacterial solute-binding protein 9 family
CW339_RS04380	COG0803	Belongs to the bacterial solute-binding protein 9 family
CW339_RS04400	COG3942	CHAP domain
CW339_RS04400	COG1705	Flagellar rod assembly protein muramidase FlgJ
CW339_RS04415	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CW339_RS04420	COG2824	Alkylphosphonate utilization operon protein PhnA
CW339_RS04425	COG0765	amino acid transport
CW339_RS04430	COG1126	abc transporter atp-binding protein
CW339_RS04435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CW339_RS04445	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CW339_RS04460	COG1064	alcohol dehydrogenase
CW339_RS04475	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CW339_RS04475	COG0519	Catalyzes the synthesis of GMP from XMP
CW339_RS04480	COG2188	Transcriptional regulator
CW339_RS04490	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CW339_RS04500	COG1827	regulation of RNA biosynthetic process
CW339_RS04510	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CW339_RS04520	COG1940	carbohydrate kinase activity
CW339_RS04525	COG0758	DNA mediated transformation
CW339_RS04530	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CW339_RS04585	COG1396	sequence-specific DNA binding
CW339_RS04595	COG3328	transposase activity
CW339_RS04600	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CW339_RS04605	COG0010	Belongs to the arginase family
CW339_RS04615	COG0028	Belongs to the TPP enzyme family
CW339_RS04620	COG3527	Alpha-acetolactate decarboxylase
CW339_RS04650	COG1230	cation diffusion facilitator family transporter
CW339_RS04660	COG1063	alcohol dehydrogenase
CW339_RS04690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CW339_RS04725	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CW339_RS04735	COG0047	phosphoribosylformylglycinamidine synthase activity
CW339_RS04750	COG0167	dihydroorotate dehydrogenase activity
CW339_RS04755	COG1468	defense response to virus
CW339_RS04755	COG1518	maintenance of DNA repeat elements
CW339_RS04760	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CW339_RS04780	COG1337	RAMP superfamily
CW339_RS04785	COG1567	CRISPR-associated RAMP protein, Csm4 family
CW339_RS04800	COG0284	orotidine-5'-phosphate decarboxylase activity
CW339_RS04815	COG3104	oligopeptide transport
CW339_RS04830	COG0737	Belongs to the 5'-nucleotidase family
CW339_RS04855	COG1115	amino acid carrier protein
CW339_RS04865	COG2873	o-acetylhomoserine
CW339_RS04900	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CW339_RS04905	COG0196	riboflavin kinase activity
CW339_RS04910	COG1393	Belongs to the ArsC family
CW339_RS04920	COG0483	inositol monophosphate 1-phosphatase activity
CW339_RS04925	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CW339_RS04925	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CW339_RS04935	COG0573	inorganic phosphate transmembrane transporter activity
CW339_RS04940	COG0581	inorganic phosphate transmembrane transporter activity
CW339_RS04955	COG0704	Plays a role in the regulation of phosphate uptake
CW339_RS04970	COG0095	Lipoate-protein ligase
CW339_RS04985	COG0058	SHG alpha-glucan phosphorylase activity
CW339_RS04990	COG1640	4-alpha-glucanotransferase
CW339_RS05010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CW339_RS05015	COG0805	protein transport
CW339_RS05020	COG0672	)-iron permease
CW339_RS05025	COG2837	iron assimilation
CW339_RS05030	COG2822	iron ion transport
CW339_RS05035	COG4607	ABC-type enterochelin transport system periplasmic component
CW339_RS05040	COG4604	ABC transporter, ATP-binding protein
CW339_RS05045	COG4605	iron ion homeostasis
CW339_RS05050	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CW339_RS05065	COG1523	belongs to the glycosyl hydrolase 13 family
CW339_RS05075	COG1523	belongs to the glycosyl hydrolase 13 family
CW339_RS05090	COG0508	dehydrogenase complex catalyzes the overall conversion of
CW339_RS05095	COG0508	dehydrogenase complex catalyzes the overall conversion of
CW339_RS05095	COG0022	dehydrogenase e1 component
CW339_RS05100	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CW339_RS05120	COG1518	maintenance of DNA repeat elements
CW339_RS05135	COG1857	crispr-associated protein
CW339_RS05170	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CW339_RS05180	COG4667	esterase of the alpha-beta hydrolase superfamily
CW339_RS05220	COG0628	permease
CW339_RS05230	COG0561	phosphatase activity
CW339_RS05255	COG0562	UDP-galactopyranose mutase
CW339_RS05265	COG2244	polysaccharide biosynthetic process
CW339_RS05270	COG1442	glycosyl transferase family 8
CW339_RS05270	COG1216	Glycosyl transferase, family 2
CW339_RS05285	COG1442	glycosyl transferase family 8
CW339_RS05285	COG1216	Glycosyl transferase, family 2
CW339_RS05335	COG1316	TRANSCRIPTIONal
CW339_RS05340	COG3328	transposase activity
CW339_RS05360	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CW339_RS05370	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CW339_RS05390	COG1573	uracil-dna glycosylase
CW339_RS05455	COG0681	Belongs to the peptidase S26 family
CW339_RS05465	COG0628	permease
CW339_RS05470	COG1051	belongs to the nudix hydrolase family
CW339_RS05475	COG2177	Part of the ABC transporter FtsEX involved in
CW339_RS05480	COG2884	Cell division ATP-binding protein ftsE
CW339_RS05490	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CW339_RS05525	COG2348	transferase activity, transferring amino-acyl groups
CW339_RS05535	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CW339_RS05540	COG5002	protein histidine kinase activity
CW339_RS05545	COG0745	RESPONSE REGULATOR receiver
CW339_RS05550	COG1126	abc transporter atp-binding protein
CW339_RS05555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CW339_RS05560	COG0765	amino acid transport
CW339_RS05565	COG0765	amino acid transport
CW339_RS05590	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CW339_RS05605	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CW339_RS05610	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CW339_RS05610	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CW339_RS05620	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CW339_RS05625	COG1956	GAF domain-containing protein
CW339_RS05630	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CW339_RS05650	COG0335	large ribosomal subunit rRNA binding
CW339_RS05655	COG0038	chloride channel
CW339_RS05665	COG0038	chloride channel
CW339_RS05670	COG0716	FMN binding
CW339_RS05740	COG0469	pyruvate kinase activity
CW339_RS05790	COG0167	dihydroorotate dehydrogenase activity
CW339_RS05800	COG0776	regulation of translation
CW339_RS05810	COG2755	lipolytic protein G-D-S-L family
CW339_RS05815	COG1307	EDD domain protein, DegV family
CW339_RS05820	COG0497	DNA recombination
CW339_RS05825	COG1438	arginine binding
CW339_RS05830	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CW339_RS05855	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CW339_RS05875	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CW339_RS05875	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CW339_RS05880	COG0300	oxidoreductase activity
CW339_RS05895	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CW339_RS05905	COG0772	Belongs to the SEDS family
CW339_RS05920	COG0107	imidazoleglycerol-phosphate synthase activity
CW339_RS05930	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CW339_RS05940	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CW339_RS05985	COG0647	UMP catabolic process
CW339_RS05995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CW339_RS06025	COG1088	dTDP-glucose 4,6-dehydratase activity
CW339_RS06035	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CW339_RS06040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CW339_RS06055	COG2384	SAM-dependent methyltransferase
CW339_RS06080	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CW339_RS06085	COG3442	glutamine amidotransferase
CW339_RS06090	COG0392	lysyltransferase activity
CW339_RS06090	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CW339_RS06105	COG0488	(ABC) transporter
CW339_RS06115	COG0513	Belongs to the DEAD box helicase family
CW339_RS06150	COG0372	Belongs to the citrate synthase family
CW339_RS06155	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CW339_RS06160	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CW339_RS06165	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CW339_RS06170	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CW339_RS06200	COG3764	Sortase (surface protein transpeptidase)
CW339_RS06220	COG0488	(ABC) transporter
CW339_RS06250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CW339_RS06255	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CW339_RS06255	COG1328	CTP reductase activity
CW339_RS06290	COG1196	nuclear chromosome segregation
CW339_RS06305	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CW339_RS06325	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CW339_RS06335	COG1011	Hydrolase
CW339_RS06340	COG1760	l-serine dehydratase
CW339_RS06375	COG2197	response regulator
CW339_RS06380	COG4585	Histidine kinase
CW339_RS06390	COG1131	(ABC) transporter
CW339_RS06430	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CW339_RS06465	COG0577	efflux transmembrane transporter activity
CW339_RS06470	COG1136	(ABC) transporter
CW339_RS06475	COG5002	protein histidine kinase activity
CW339_RS06475	COG2198	Histidine kinase
CW339_RS06475	COG0784	Response regulator, receiver
CW339_RS06480	COG0745	RESPONSE REGULATOR receiver
CW339_RS06495	COG0534	Mate efflux family protein
CW339_RS06500	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CW339_RS06500	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CW339_RS06530	COG0531	amino acid
CW339_RS06540	COG2514	catechol 2,3-dioxygenase activity
CW339_RS06545	COG1959	2 iron, 2 sulfur cluster binding
CW339_RS06555	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CW339_RS06560	COG0778	Nitroreductase
CW339_RS06570	COG0656	L-ascorbic acid biosynthetic process
CW339_RS06575	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CW339_RS06615	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CW339_RS06640	COG1280	lysine exporter protein (LysE YggA)
CW339_RS06655	COG1216	Glycosyl transferase, family 2
CW339_RS06655	COG1442	glycosyl transferase family 8
CW339_RS06660	COG0577	efflux transmembrane transporter activity
CW339_RS06715	COG1396	sequence-specific DNA binding
CW339_RS06730	COG0419	ATPase involved in DNA repair
CW339_RS06735	COG0420	3'-5' exonuclease activity
CW339_RS06745	COG3250	beta-galactosidase activity
CW339_RS06750	COG2211	Major facilitator Superfamily
CW339_RS06750	COG2190	(PTS) system
CW339_RS06755	COG2017	converts alpha-aldose to the beta-anomer
CW339_RS06760	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CW339_RS06775	COG1609	Transcriptional regulator
CW339_RS06800	COG0488	(ABC) transporter
CW339_RS06865	COG2197	response regulator
CW339_RS06870	COG4585	Histidine kinase
CW339_RS06885	COG0515	serine threonine protein kinase
CW339_RS06885	COG2815	serine threonine protein kinase
CW339_RS06895	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CW339_RS06895	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CW339_RS06905	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CW339_RS06920	COG0552	protein localization to endoplasmic reticulum
CW339_RS06925	COG0561	phosphatase activity
CW339_RS06930	COG0561	phosphatase activity
CW339_RS06935	COG1725	Transcriptional regulator
CW339_RS06940	COG1131	(ABC) transporter
CW339_RS06950	COG4608	Belongs to the ABC transporter superfamily
CW339_RS06955	COG0444	Belongs to the ABC transporter superfamily
CW339_RS06960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CW339_RS06965	COG0601	transmembrane transport
CW339_RS06970	COG4166	transmembrane transport
CW339_RS06980	COG4166	transmembrane transport
CW339_RS07000	COG0084	hydrolase, TatD family'
CW339_RS07005	COG2223	nitrite transmembrane transporter activity
CW339_RS07015	COG0280	phosphate acetyltransferase
CW339_RS07020	COG0564	pseudouridine synthase activity
CW339_RS07030	COG2357	RelA SpoT domain protein
CW339_RS07045	COG1104	cysteine desulfurase activity
CW339_RS07060	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CW339_RS07065	COG2003	Belongs to the UPF0758 family
CW339_RS07090	COG1215	transferase activity, transferring glycosyl groups
CW339_RS07105	COG1442	glycosyl transferase family 8
CW339_RS07105	COG1216	Glycosyl transferase, family 2
CW339_RS07125	COG1091	dTDP-4-dehydrorhamnose reductase activity
CW339_RS07135	COG0463	Glycosyl transferase, family 2
CW339_RS07140	COG2151	metal-sulfur cluster biosynthetic enzyme
CW339_RS07145	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CW339_RS07150	COG0358	DNA primase activity
CW339_RS07165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CW339_RS07170	COG0436	Aminotransferase
CW339_RS07175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CW339_RS07180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CW339_RS07185	COG1051	belongs to the nudix hydrolase family
CW339_RS07205	COG0765	amino acid transport
CW339_RS07210	COG1126	abc transporter atp-binding protein
CW339_RS07270	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CW339_RS07275	COG1518	maintenance of DNA repeat elements
CW339_RS07280	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
CW339_RS07285	COG0560	Phosphoserine phosphatase
CW339_RS07295	COG0187	DNA topoisomerase II activity
CW339_RS07305	COG1346	cytolysis
CW339_RS07310	COG1380	Effector of murein hydrolase LrgA
CW339_RS07320	COG1393	Belongs to the ArsC family
CW339_RS07330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CW339_RS07365	COG1177	transmembrane transport
CW339_RS07370	COG1176	ABC-type spermidine putrescine transport system, permease component I
CW339_RS07410	COG0531	amino acid
CW339_RS07415	COG0285	dihydrofolate synthase activity
CW339_RS07420	COG1837	Belongs to the UPF0109 family
CW339_RS07430	COG0500	methyltransferase
CW339_RS07430	COG3615	Tellurite resistance protein tehB
CW339_RS07440	COG0708	Exodeoxyribonuclease III
CW339_RS07455	COG1597	lipid kinase activity
CW339_RS07465	COG4708	membrane
CW339_RS07475	COG0024	Methionine aminopeptidase
CW339_RS07480	COG4109	DRTGG domain
CW339_RS07490	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CW339_RS07495	COG2333	competence protein COMEC
CW339_RS07495	COG0658	competence protein
CW339_RS07500	COG1555	photosystem II stabilization
CW339_RS07500	COG1596	polysaccharide export
CW339_RS07505	COG0204	Acyl-transferase
CW339_RS07510	COG0726	polysaccharide deacetylase
CW339_RS07515	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CW339_RS07525	COG0513	Belongs to the DEAD box helicase family
CW339_RS07545	COG1396	sequence-specific DNA binding
CW339_RS07550	COG2211	Major facilitator Superfamily
CW339_RS07565	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CW339_RS07580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CW339_RS07585	COG1126	abc transporter atp-binding protein
CW339_RS07590	COG0765	amino acid transport
CW339_RS07595	COG0765	amino acid transport
CW339_RS07610	COG2217	Heavy metal translocating P-type atpase
CW339_RS07620	COG0159	tryptophan synthase activity
CW339_RS07630	COG0135	phosphoribosylanthranilate isomerase activity
CW339_RS07645	COG0512	Glutamine amidotransferase of anthranilate synthase
CW339_RS07650	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CW339_RS07655	COG1605	Chorismate mutase
CW339_RS07655	COG0287	Prephenate dehydrogenase
CW339_RS07665	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CW339_RS07690	COG2176	DNA-directed DNA polymerase activity
CW339_RS07700	COG2151	metal-sulfur cluster biosynthetic enzyme
CW339_RS07710	COG2081	HI0933 family
CW339_RS07735	COG1131	(ABC) transporter
CW339_RS07740	COG0537	adenosine 5'-monophosphoramidase activity
CW339_RS07770	COG2226	methyltransferase
CW339_RS07780	COG0799	negative regulation of ribosome biogenesis
CW339_RS07785	COG1713	HD superfamily hydrolase involved in NAD metabolism
CW339_RS07790	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CW339_RS07795	COG1534	Rna-binding protein
CW339_RS07800	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CW339_RS07805	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CW339_RS07860	COG1335	isochorismatase
CW339_RS07870	COG0436	Aminotransferase
CW339_RS07875	COG0589	response to stress
CW339_RS07890	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CW339_RS07900	COG1253	flavin adenine dinucleotide binding
CW339_RS07905	COG1119	ATPase activity
CW339_RS07910	COG0025	NhaP-type Na H and K H
CW339_RS07920	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CW339_RS07925	COG1242	4 iron, 4 sulfur cluster binding
CW339_RS07930	COG3480	Lon protease (S16) C-terminal proteolytic domain
CW339_RS07935	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CW339_RS07940	COG0742	ribosomal rna small subunit methyltransferase
CW339_RS07945	COG0492	ferredoxin-NADP+ reductase activity
CW339_RS07955	COG1126	abc transporter atp-binding protein
CW339_RS07965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CW339_RS07980	COG1882	Formate acetyltransferase
CW339_RS08010	COG0390	transport system, permease component
CW339_RS08015	COG4619	ABC transporter
CW339_RS08020	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CW339_RS08035	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CW339_RS08115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CW339_RS08135	COG1132	(ABC) transporter
CW339_RS08140	COG1132	(ABC) transporter
CW339_RS08155	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CW339_RS08160	COG4470	Protein conserved in bacteria
CW339_RS08165	COG0737	Belongs to the 5'-nucleotidase family
CW339_RS08170	COG0513	Belongs to the DEAD box helicase family
CW339_RS08180	COG0768	penicillin binding
CW339_RS08210	COG3152	Membrane
CW339_RS08220	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CW339_RS08235	COG4152	abc transporter atp-binding protein
CW339_RS08240	COG1811	Na channel or pump
CW339_RS08280	COG0561	phosphatase activity
CW339_RS08285	COG0252	asparaginase activity
CW339_RS08290	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CW339_RS08295	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CW339_RS08305	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CW339_RS08310	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CW339_RS08325	COG1482	cell wall glycoprotein biosynthetic process
CW339_RS08330	COG1940	carbohydrate kinase activity
CW339_RS08335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CW339_RS08335	COG2190	(PTS) system
CW339_RS08335	COG1263	PTS System
CW339_RS08340	COG1621	beta-fructofuranosidase activity
CW339_RS08345	COG1609	Transcriptional regulator
CW339_RS08365	COG2131	deaminase
CW339_RS08370	COG0006	proline dipeptidase activity
CW339_RS08385	COG1131	(ABC) transporter
CW339_RS08460	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CW339_RS08460	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CW339_RS08485	COG0681	Belongs to the peptidase S26 family
CW339_RS08490	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CW339_RS08500	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CW339_RS08510	COG0456	acetyltransferase
CW339_RS08515	COG1214	PFAM Peptidase M22, glycoprotease
CW339_RS08535	COG0174	glutamine synthetase
CW339_RS08540	COG0789	Transcriptional regulator
CW339_RS08595	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CW339_RS08640	COG0084	hydrolase, TatD family'
CW339_RS08645	COG1832	CoA-binding protein
CW339_RS08650	COG3118	belongs to the thioredoxin family
CW339_RS08720	COG0706	membrane insertase activity
CW339_RS08745	COG4166	transmembrane transport
CW339_RS08750	COG4166	transmembrane transport
CW339_RS08790	COG0756	dUTP diphosphatase activity
CW339_RS08820	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CW339_RS08825	COG0705	Rhomboid family
CW339_RS08825	COG0457	Tetratricopeptide repeat
CW339_RS08830	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CW339_RS08850	COG2226	methyltransferase
CW339_RS08880	COG0425	Belongs to the sulfur carrier protein TusA family
CW339_RS08885	COG2391	methyltransferase activity
CW339_RS08890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CW339_RS08895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CW339_RS08905	COG1363	Peptidase, m42
CW339_RS08910	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CW339_RS08915	COG1266	CAAX protease self-immunity
CW339_RS08975	COG1459	type II secretion system
CW339_RS08980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CW339_RS09015	COG0440	acetolactate synthase activity
CW339_RS09020	COG0028	Belongs to the TPP enzyme family
CW339_RS09030	COG1461	Dihydroxyacetone kinase
CW339_RS09040	COG0534	Mate efflux family protein
CW339_RS09060	COG1454	alcohol dehydrogenase
CW339_RS09060	COG1012	belongs to the aldehyde dehydrogenase family
CW339_RS09065	COG1454	alcohol dehydrogenase
CW339_RS09065	COG1012	belongs to the aldehyde dehydrogenase family
CW339_RS09070	COG1012	belongs to the aldehyde dehydrogenase family
CW339_RS09070	COG1454	alcohol dehydrogenase
CW339_RS09075	COG1012	belongs to the aldehyde dehydrogenase family
CW339_RS09075	COG1454	alcohol dehydrogenase
CW339_RS09080	COG3590	peptidase
CW339_RS09095	COG1609	Transcriptional regulator
CW339_RS09100	COG2188	Transcriptional regulator
CW339_RS09105	COG4475	Protein of unknown function (DUF436)
CW339_RS09140	COG0640	Transcriptional regulator
CW339_RS09145	COG2217	Heavy metal translocating P-type atpase
CW339_RS09170	COG3328	transposase activity
CW339_RS09175	COG0582	viral genome integration into host DNA
CW339_RS09180	COG0191	fructose-bisphosphate aldolase activity
CW339_RS09250	COG0201	protein transport
CW339_RS09395	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CW339_RS09410	COG0515	serine threonine protein kinase
CW339_RS09415	COG1132	(ABC) transporter
CW339_RS09420	COG1396	sequence-specific DNA binding
CW339_RS09430	COG1132	(ABC) transporter
CW339_RS09465	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CW339_RS09510	COG0602	queuosine metabolic process
CW339_RS09520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CW339_RS09550	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CW339_RS09560	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CW339_RS09590	COG2261	transglycosylase associated protein
CW339_RS09610	COG3237	CsbD-like
CW339_RS09620	COG3328	transposase activity
CW339_RS09640	COG1511	domain protein
CW339_RS09640	COG1511	domain protein
CW339_RS09650	COG3759	membrane
CW339_RS09665	COG0305	Participates in initiation and elongation during chromosome replication
CW339_RS09685	COG0494	nUDIX hydrolase
CW339_RS09700	COG0741	lytic transglycosylase activity
CW339_RS09705	COG1388	LysM domain
CW339_RS09705	COG3584	3D domain protein
CW339_RS09710	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CW339_RS09725	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CW339_RS09735	COG0612	Peptidase, M16
CW339_RS09765	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CW339_RS09770	COG0488	(ABC) transporter
CW339_RS09805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CW339_RS09810	COG1475	DNA binding