locus-tag	class	description
CR921_RS00010	COG0592	DNA-directed DNA polymerase activity
CR921_RS00025	COG0012	GTP binding
CR921_RS00035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CR921_RS00040	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CR921_RS00070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CR921_RS00200	COG3942	CHAP domain
CR921_RS00215	COG0436	Aminotransferase
CR921_RS00230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CR921_RS00240	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CR921_RS00255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CR921_RS00270	COG1388	LysM domain
CR921_RS00270	COG3942	CHAP domain
CR921_RS00275	COG0151	Belongs to the GarS family
CR921_RS00280	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CR921_RS00300	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CR921_RS00315	COG4550	Control of competence regulator ComK, YlbF/YmcA
CR921_RS00355	COG2818	Glycosylase
CR921_RS00370	COG1393	Belongs to the ArsC family
CR921_RS00460	COG2309	aminopeptidase activity
CR921_RS00475	COG0431	NADPH-dependent FMN reductase
CR921_RS00515	COG4463	regulation of RNA biosynthetic process
CR921_RS00520	COG0542	response to heat
CR921_RS00530	COG1686	Belongs to the peptidase S11 family
CR921_RS00545	COG1045	serine acetyltransferase
CR921_RS00555	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CR921_RS00570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CR921_RS00595	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CR921_RS00675	COG3830	Belongs to the UPF0237 family
CR921_RS00690	COG1876	peptidase activity
CR921_RS00725	COG0351	phosphomethylpyrimidine kinase
CR921_RS00830	COG1473	amidohydrolase
CR921_RS00835	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CR921_RS00855	COG0668	transmembrane transport
CR921_RS00870	COG0504	CTP synthase activity
CR921_RS00880	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CR921_RS00890	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CR921_RS00895	COG0737	Belongs to the 5'-nucleotidase family
CR921_RS00930	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CR921_RS00965	COG1126	abc transporter atp-binding protein
CR921_RS00970	COG0765	amino acid transport
CR921_RS00975	COG1968	undecaprenyl-diphosphatase activity
CR921_RS00990	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CR921_RS01000	COG0719	Fe-S assembly protein
CR921_RS01005	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CR921_RS01015	COG0719	Fe-S assembly protein
CR921_RS01040	COG4608	Belongs to the ABC transporter superfamily
CR921_RS01055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CR921_RS01070	COG1121	(ABC) transporter
CR921_RS01075	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CR921_RS01115	COG4589	Belongs to the CDS family
CR921_RS01130	COG4120	Belongs to the binding-protein-dependent transport system permease family
CR921_RS01135	COG1116	anion transmembrane transporter activity
CR921_RS01135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CR921_RS01170	COG0564	pseudouridine synthase activity
CR921_RS01175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CR921_RS01200	COG0561	phosphatase activity
CR921_RS01240	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CR921_RS01255	COG3579	cysteine-type endopeptidase activity
CR921_RS01260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CR921_RS01285	COG0116	Belongs to the methyltransferase superfamily
CR921_RS01295	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CR921_RS01315	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CR921_RS01340	COG1254	Belongs to the acylphosphatase family
CR921_RS01345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CR921_RS01390	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CR921_RS01410	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CR921_RS01415	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CR921_RS01420	COG1187	pseudouridine synthase activity
CR921_RS01430	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CR921_RS01435	COG0569	domain protein
CR921_RS01445	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CR921_RS01450	COG0671	phosphoesterase, PA-phosphatase related
CR921_RS01465	COG2274	protein secretion by the type I secretion system
CR921_RS01470	COG2274	protein secretion by the type I secretion system
CR921_RS01475	COG2274	protein secretion by the type I secretion system
CR921_RS01525	COG0829	nickel cation binding
CR921_RS01530	COG0310	cobalt ion transport
CR921_RS01540	COG1122	ATPase activity
CR921_RS01545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CR921_RS01550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CR921_RS01570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CR921_RS01575	COG1464	Belongs to the NlpA lipoprotein family
CR921_RS01595	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CR921_RS01610	COG1122	ATPase activity
CR921_RS01620	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CR921_RS01635	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CR921_RS01650	COG0745	RESPONSE REGULATOR receiver
CR921_RS01655	COG5002	protein histidine kinase activity
CR921_RS01670	COG1484	DNA-dependent DNA replication
CR921_RS01700	COG3328	transposase activity
CR921_RS01715	COG3716	PTS system mannose fructose sorbose family IID component
CR921_RS01720	COG3715	PTS system
CR921_RS01730	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CR921_RS01735	COG0561	phosphatase activity
CR921_RS01740	COG2252	PERMEase
CR921_RS01745	COG0802	atpase or kinase
CR921_RS01750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CR921_RS01755	COG1316	TRANSCRIPTIONal
CR921_RS01765	COG0195	Participates in both transcription termination and antitermination
CR921_RS01770	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CR921_RS01790	COG1611	Belongs to the LOG family
CR921_RS01810	COG2244	polysaccharide biosynthetic process
CR921_RS01815	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CR921_RS01820	COG0626	cystathionine gamma-synthase activity
CR921_RS01825	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CR921_RS01855	COG4471	UPF0298 protein
CR921_RS01865	COG0559	Belongs to the binding-protein-dependent transport system permease family
CR921_RS01895	COG1739	Uncharacterized protein family UPF0029
CR921_RS01900	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CR921_RS01905	COG1040	competence protein
CR921_RS01995	COG0527	aspartate kinase activity
CR921_RS02000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CR921_RS02005	COG1024	Enoyl-CoA hydratase
CR921_RS02010	COG1846	Transcriptional regulator
CR921_RS02030	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CR921_RS02035	COG1028	Short-chain dehydrogenase reductase Sdr
CR921_RS02040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CR921_RS02055	COG0439	Biotin carboxylase
CR921_RS02075	COG0732	type I restriction modification DNA specificity domain
CR921_RS02090	COG0076	glutamate decarboxylase activity
CR921_RS02095	COG0531	amino acid
CR921_RS02145	COG1349	DNA-binding transcription factor activity
CR921_RS02150	COG1105	Belongs to the carbohydrate kinase PfkB family
CR921_RS02155	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CR921_RS02155	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CR921_RS02155	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CR921_RS02160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CR921_RS02165	COG0285	dihydrofolate synthase activity
CR921_RS02175	COG1104	cysteine desulfurase activity
CR921_RS02235	COG0488	(ABC) transporter
CR921_RS02255	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CR921_RS02260	COG0242	peptide deformylase activity
CR921_RS02320	COG1702	phosphate starvation-inducible protein PhoH
CR921_RS02340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CR921_RS02340	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CR921_RS02370	COG4122	O-methyltransferase activity
CR921_RS02375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CR921_RS02405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CR921_RS02410	COG0436	Aminotransferase
CR921_RS02425	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CR921_RS02430	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CR921_RS02435	COG0726	polysaccharide deacetylase
CR921_RS02450	COG2962	Rard protein
CR921_RS02490	COG0356	it plays a direct role in the translocation of protons across the membrane
CR921_RS02525	COG0772	Belongs to the SEDS family
CR921_RS02545	COG0470	DNA polymerase III
CR921_RS02550	COG1774	PSP1 C-terminal conserved region
CR921_RS02555	COG4467	Involved in initiation control of chromosome replication
CR921_RS02565	COG0004	ammonium transporteR
CR921_RS02570	COG0347	Belongs to the P(II) protein family
CR921_RS02575	COG1705	Flagellar rod assembly protein muramidase FlgJ
CR921_RS02575	COG1388	LysM domain
CR921_RS02620	COG1113	amino acid transport
CR921_RS02630	COG2190	(PTS) system
CR921_RS02630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CR921_RS02630	COG1263	PTS System
CR921_RS02635	COG1263	PTS System
CR921_RS02635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CR921_RS02635	COG2190	(PTS) system
CR921_RS02670	COG0583	DNA-binding transcription factor activity
CR921_RS02680	COG0564	pseudouridine synthase activity
CR921_RS02700	COG0505	Belongs to the CarA family
CR921_RS02800	COG3344	reverse transcriptase
CR921_RS02825	COG3843	relaxase mobilization nuclease domain protein
CR921_RS02830	COG3328	transposase activity
CR921_RS02860	COG3279	Response regulator of the LytR AlgR family
CR921_RS02870	COG1131	(ABC) transporter
CR921_RS02905	COG1187	pseudouridine synthase activity
CR921_RS02910	COG1473	amidohydrolase
CR921_RS02915	COG0686	Belongs to the AlaDH PNT family
CR921_RS02920	COG0686	Belongs to the AlaDH PNT family
CR921_RS02930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CR921_RS02995	COG0438	transferase activity, transferring glycosyl groups
CR921_RS03030	COG1272	protein, Hemolysin III
CR921_RS03045	COG3425	synthase
CR921_RS03055	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CR921_RS03075	COG0833	amino acid
CR921_RS03080	COG2040	homocysteine
CR921_RS03100	COG0187	DNA topoisomerase II activity
CR921_RS03110	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CR921_RS03130	COG0539	negative regulation of cytoplasmic translation
CR921_RS03170	COG0494	nUDIX hydrolase
CR921_RS03175	COG0542	response to heat
CR921_RS03180	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CR921_RS03185	COG4703	Protein of unknown function (DUF1797)
CR921_RS03190	COG0765	amino acid transport
CR921_RS03230	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CR921_RS03235	COG0768	penicillin binding
CR921_RS03240	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CR921_RS03245	COG3711	transcriptional antiterminator
CR921_RS03255	COG3711	transcriptional antiterminator
CR921_RS03265	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CR921_RS03270	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CR921_RS03275	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CR921_RS03280	COG0237	dephospho-CoA kinase activity
CR921_RS03285	COG2814	Major facilitator Superfamily
CR921_RS03300	COG0557	exoribonuclease II activity
CR921_RS03315	COG1185	polyribonucleotide nucleotidyltransferase activity
CR921_RS03320	COG0006	proline dipeptidase activity
CR921_RS03325	COG1609	Transcriptional regulator
CR921_RS03360	COG1368	sulfuric ester hydrolase activity
CR921_RS03365	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CR921_RS03390	COG0287	Prephenate dehydrogenase
CR921_RS03415	COG0077	Prephenate dehydratase
CR921_RS03480	COG1518	maintenance of DNA repeat elements
CR921_RS03485	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CR921_RS03495	COG3689	TIGRFAM TIGR03943 family protein
CR921_RS03500	COG0701	Predicted permease
CR921_RS03505	COG2183	response to ionizing radiation
CR921_RS03525	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CR921_RS03550	COG0826	peptidase U32
CR921_RS03560	COG1268	BioY protein
CR921_RS03570	COG4443	Transcriptional Coactivator p15 (PC4)
CR921_RS03575	COG1914	H( )-stimulated, divalent metal cation uptake system
CR921_RS03600	COG1388	LysM domain
CR921_RS03600	COG1705	Flagellar rod assembly protein muramidase FlgJ
CR921_RS03620	COG0406	alpha-ribazole phosphatase activity
CR921_RS03625	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CR921_RS03655	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CR921_RS03665	COG0732	type I restriction modification DNA specificity domain
CR921_RS03685	COG1704	LemA family
CR921_RS03690	COG0501	Belongs to the peptidase M48B family
CR921_RS03715	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CR921_RS03730	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CR921_RS03735	COG0783	Belongs to the Dps family
CR921_RS03740	COG0735	belongs to the Fur family
CR921_RS03745	COG4483	Protein conserved in bacteria
CR921_RS03750	COG1940	carbohydrate kinase activity
CR921_RS03755	COG1217	gtp-binding protein TYPA
CR921_RS03780	COG0849	cell division
CR921_RS03790	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CR921_RS03815	COG3599	regulation of cell shape
CR921_RS03850	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CR921_RS03855	COG0625	glutathione transferase activity
CR921_RS03875	COG2890	protein-(glutamine-N5) methyltransferase activity
CR921_RS03905	COG1132	(ABC) transporter
CR921_RS03920	COG1696	Membrane protein involved in D-alanine export
CR921_RS03930	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CR921_RS03945	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CR921_RS03950	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CR921_RS03970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CR921_RS03975	COG4684	Psort location CytoplasmicMembrane, score
CR921_RS03980	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CR921_RS04005	COG5002	protein histidine kinase activity
CR921_RS04035	COG0038	chloride channel
CR921_RS04070	COG2813	Specifically methylates the guanine in position
CR921_RS04080	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CR921_RS04100	COG1744	ABC transporter substrate-binding protein PnrA-like
CR921_RS04105	COG3845	ABC transporter
CR921_RS04110	COG4603	Belongs to the binding-protein-dependent transport system permease family
CR921_RS04115	COG1079	Belongs to the binding-protein-dependent transport system permease family
CR921_RS04125	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CR921_RS04125	COG1199	ATP-dependent helicase activity
CR921_RS04135	COG0436	Aminotransferase
CR921_RS04155	COG0251	oxidation-reduction process
CR921_RS04165	COG0720	synthase
CR921_RS04225	COG1278	Cold shock
CR921_RS04240	COG2217	Heavy metal translocating P-type atpase
CR921_RS04260	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CR921_RS04265	COG0626	cystathionine gamma-synthase activity
CR921_RS04270	COG1045	serine acetyltransferase
CR921_RS04290	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CR921_RS04300	COG4975	Glucose uptake
CR921_RS04325	COG0803	Belongs to the bacterial solute-binding protein 9 family
CR921_RS04325	COG3443	Belongs to the bacterial solute-binding protein 9 family
CR921_RS04345	COG1705	Flagellar rod assembly protein muramidase FlgJ
CR921_RS04345	COG3942	CHAP domain
CR921_RS04360	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CR921_RS04365	COG2824	Alkylphosphonate utilization operon protein PhnA
CR921_RS04370	COG0765	amino acid transport
CR921_RS04375	COG1126	abc transporter atp-binding protein
CR921_RS04380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CR921_RS04400	COG1064	alcohol dehydrogenase
CR921_RS04405	COG1064	alcohol dehydrogenase
CR921_RS04415	COG3421	Type III restriction
CR921_RS04420	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CR921_RS04425	COG0519	Catalyzes the synthesis of GMP from XMP
CR921_RS04425	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CR921_RS04430	COG2188	Transcriptional regulator
CR921_RS04440	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CR921_RS04450	COG1827	regulation of RNA biosynthetic process
CR921_RS04460	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CR921_RS04470	COG1940	carbohydrate kinase activity
CR921_RS04475	COG0758	DNA mediated transformation
CR921_RS04480	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CR921_RS04500	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CR921_RS04535	COG1396	sequence-specific DNA binding
CR921_RS04545	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CR921_RS04550	COG0010	Belongs to the arginase family
CR921_RS04560	COG0028	Belongs to the TPP enzyme family
CR921_RS04565	COG3527	Alpha-acetolactate decarboxylase
CR921_RS04595	COG1230	cation diffusion facilitator family transporter
CR921_RS04605	COG1063	alcohol dehydrogenase
CR921_RS04635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CR921_RS04655	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CR921_RS04665	COG0047	phosphoribosylformylglycinamidine synthase activity
CR921_RS04680	COG0167	dihydroorotate dehydrogenase activity
CR921_RS04690	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CR921_RS04700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CR921_RS04705	COG2274	protein secretion by the type I secretion system
CR921_RS04850	COG3104	oligopeptide transport
CR921_RS04890	COG1115	amino acid carrier protein
CR921_RS04900	COG2873	o-acetylhomoserine
CR921_RS04935	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CR921_RS04940	COG0196	riboflavin kinase activity
CR921_RS04945	COG1393	Belongs to the ArsC family
CR921_RS04955	COG0483	inositol monophosphate 1-phosphatase activity
CR921_RS04960	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CR921_RS04960	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CR921_RS04970	COG0573	inorganic phosphate transmembrane transporter activity
CR921_RS04975	COG0581	inorganic phosphate transmembrane transporter activity
CR921_RS04990	COG0704	Plays a role in the regulation of phosphate uptake
CR921_RS05005	COG0095	Lipoate-protein ligase
CR921_RS05020	COG0058	SHG alpha-glucan phosphorylase activity
CR921_RS05025	COG1640	4-alpha-glucanotransferase
CR921_RS05045	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CR921_RS05050	COG0805	protein transport
CR921_RS05055	COG0672	)-iron permease
CR921_RS05060	COG2837	iron assimilation
CR921_RS05065	COG2822	iron ion transport
CR921_RS05070	COG4607	ABC-type enterochelin transport system periplasmic component
CR921_RS05075	COG4604	ABC transporter, ATP-binding protein
CR921_RS05080	COG4605	iron ion homeostasis
CR921_RS05085	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CR921_RS05100	COG1523	belongs to the glycosyl hydrolase 13 family
CR921_RS05110	COG1523	belongs to the glycosyl hydrolase 13 family
CR921_RS05125	COG0508	dehydrogenase complex catalyzes the overall conversion of
CR921_RS05130	COG0508	dehydrogenase complex catalyzes the overall conversion of
CR921_RS05130	COG0022	dehydrogenase e1 component
CR921_RS05135	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CR921_RS05165	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CR921_RS05170	COG4667	esterase of the alpha-beta hydrolase superfamily
CR921_RS05210	COG0628	permease
CR921_RS05220	COG0561	phosphatase activity
CR921_RS05245	COG0438	transferase activity, transferring glycosyl groups
CR921_RS05250	COG0562	UDP-galactopyranose mutase
CR921_RS05265	COG1216	Glycosyl transferase, family 2
CR921_RS05270	COG1442	glycosyl transferase family 8
CR921_RS05270	COG1216	Glycosyl transferase, family 2
CR921_RS05320	COG1316	TRANSCRIPTIONal
CR921_RS05340	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CR921_RS05370	COG1573	uracil-dna glycosylase
CR921_RS05435	COG0681	Belongs to the peptidase S26 family
CR921_RS05445	COG0628	permease
CR921_RS05450	COG1051	belongs to the nudix hydrolase family
CR921_RS05455	COG2177	Part of the ABC transporter FtsEX involved in
CR921_RS05460	COG2884	Cell division ATP-binding protein ftsE
CR921_RS05470	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CR921_RS05505	COG2348	transferase activity, transferring amino-acyl groups
CR921_RS05515	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CR921_RS05520	COG5002	protein histidine kinase activity
CR921_RS05525	COG0745	RESPONSE REGULATOR receiver
CR921_RS05530	COG1126	abc transporter atp-binding protein
CR921_RS05535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CR921_RS05540	COG0765	amino acid transport
CR921_RS05545	COG0765	amino acid transport
CR921_RS05570	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CR921_RS05615	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CR921_RS05620	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CR921_RS05620	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CR921_RS05630	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CR921_RS05635	COG1956	GAF domain-containing protein
CR921_RS05660	COG0335	large ribosomal subunit rRNA binding
CR921_RS05665	COG0038	chloride channel
CR921_RS05675	COG0038	chloride channel
CR921_RS05680	COG0716	FMN binding
CR921_RS05750	COG0469	pyruvate kinase activity
CR921_RS05800	COG0167	dihydroorotate dehydrogenase activity
CR921_RS05810	COG0776	regulation of translation
CR921_RS05820	COG2755	lipolytic protein G-D-S-L family
CR921_RS05825	COG1307	EDD domain protein, DegV family
CR921_RS05830	COG0497	DNA recombination
CR921_RS05835	COG1438	arginine binding
CR921_RS05840	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CR921_RS05865	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CR921_RS05885	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CR921_RS05885	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CR921_RS05890	COG0300	oxidoreductase activity
CR921_RS05905	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CR921_RS05915	COG0772	Belongs to the SEDS family
CR921_RS05930	COG0107	imidazoleglycerol-phosphate synthase activity
CR921_RS05940	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CR921_RS05950	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CR921_RS05995	COG0647	UMP catabolic process
CR921_RS06005	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CR921_RS06030	COG1088	dTDP-glucose 4,6-dehydratase activity
CR921_RS06040	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CR921_RS06045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CR921_RS06060	COG2384	SAM-dependent methyltransferase
CR921_RS06085	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CR921_RS06090	COG3442	glutamine amidotransferase
CR921_RS06095	COG0392	lysyltransferase activity
CR921_RS06095	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CR921_RS06110	COG0488	(ABC) transporter
CR921_RS06120	COG0513	Belongs to the DEAD box helicase family
CR921_RS06150	COG0372	Belongs to the citrate synthase family
CR921_RS06155	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CR921_RS06160	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CR921_RS06165	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CR921_RS06170	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CR921_RS06200	COG3764	Sortase (surface protein transpeptidase)
CR921_RS06220	COG0488	(ABC) transporter
CR921_RS06245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CR921_RS06250	COG1328	CTP reductase activity
CR921_RS06250	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CR921_RS06285	COG1196	nuclear chromosome segregation
CR921_RS06300	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CR921_RS06310	COG1247	-acetyltransferase
CR921_RS06320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CR921_RS06330	COG1011	Hydrolase
CR921_RS06335	COG1760	l-serine dehydratase
CR921_RS06340	COG1760	l-serine dehydratase
CR921_RS06375	COG4585	Histidine kinase
CR921_RS06385	COG1131	(ABC) transporter
CR921_RS06425	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CR921_RS06460	COG0577	efflux transmembrane transporter activity
CR921_RS06465	COG1136	(ABC) transporter
CR921_RS06470	COG5002	protein histidine kinase activity
CR921_RS06470	COG2198	Histidine kinase
CR921_RS06470	COG0784	Response regulator, receiver
CR921_RS06475	COG0745	RESPONSE REGULATOR receiver
CR921_RS06490	COG0534	Mate efflux family protein
CR921_RS06495	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CR921_RS06495	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CR921_RS06525	COG0531	amino acid
CR921_RS06545	COG1126	abc transporter atp-binding protein
CR921_RS06550	COG0765	amino acid transport
CR921_RS06555	COG0765	amino acid transport
CR921_RS06560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CR921_RS06570	COG0386	Belongs to the glutathione peroxidase family
CR921_RS06605	COG2514	catechol 2,3-dioxygenase activity
CR921_RS06610	COG1959	2 iron, 2 sulfur cluster binding
CR921_RS06620	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CR921_RS06625	COG0778	Nitroreductase
CR921_RS06635	COG0656	L-ascorbic acid biosynthetic process
CR921_RS06640	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CR921_RS06680	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CR921_RS06700	COG1280	lysine exporter protein (LysE YggA)
CR921_RS06715	COG1216	Glycosyl transferase, family 2
CR921_RS06715	COG1442	glycosyl transferase family 8
CR921_RS06720	COG0577	efflux transmembrane transporter activity
CR921_RS06775	COG1396	sequence-specific DNA binding
CR921_RS06790	COG0419	ATPase involved in DNA repair
CR921_RS06795	COG0420	3'-5' exonuclease activity
CR921_RS06805	COG3250	beta-galactosidase activity
CR921_RS06810	COG2211	Major facilitator Superfamily
CR921_RS06810	COG2190	(PTS) system
CR921_RS06815	COG2017	converts alpha-aldose to the beta-anomer
CR921_RS06820	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CR921_RS06835	COG1609	Transcriptional regulator
CR921_RS06860	COG0488	(ABC) transporter
CR921_RS06915	COG2197	response regulator
CR921_RS06920	COG4585	Histidine kinase
CR921_RS06935	COG0515	serine threonine protein kinase
CR921_RS06935	COG2815	serine threonine protein kinase
CR921_RS06945	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CR921_RS06945	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CR921_RS06955	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CR921_RS06970	COG0552	protein localization to endoplasmic reticulum
CR921_RS06975	COG0561	phosphatase activity
CR921_RS06980	COG0561	phosphatase activity
CR921_RS06985	COG1725	Transcriptional regulator
CR921_RS06990	COG1131	(ABC) transporter
CR921_RS07000	COG4608	Belongs to the ABC transporter superfamily
CR921_RS07005	COG0444	Belongs to the ABC transporter superfamily
CR921_RS07010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CR921_RS07015	COG0601	transmembrane transport
CR921_RS07020	COG4166	transmembrane transport
CR921_RS07030	COG4166	transmembrane transport
CR921_RS07040	COG4608	Belongs to the ABC transporter superfamily
CR921_RS07045	COG4608	Belongs to the ABC transporter superfamily
CR921_RS07050	COG0084	hydrolase, TatD family'
CR921_RS07055	COG2223	nitrite transmembrane transporter activity
CR921_RS07065	COG0280	phosphate acetyltransferase
CR921_RS07070	COG0564	pseudouridine synthase activity
CR921_RS07080	COG2357	RelA SpoT domain protein
CR921_RS07095	COG1104	cysteine desulfurase activity
CR921_RS07110	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CR921_RS07115	COG2003	Belongs to the UPF0758 family
CR921_RS07150	COG3328	transposase activity
CR921_RS07170	COG1216	Glycosyl transferase, family 2
CR921_RS07170	COG1442	glycosyl transferase family 8
CR921_RS07185	COG0463	Glycosyl transferase, family 2
CR921_RS07190	COG1442	glycosyl transferase family 8
CR921_RS07205	COG1091	dTDP-4-dehydrorhamnose reductase activity
CR921_RS07215	COG0463	Glycosyl transferase, family 2
CR921_RS07220	COG2151	metal-sulfur cluster biosynthetic enzyme
CR921_RS07225	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CR921_RS07230	COG0358	DNA primase activity
CR921_RS07245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CR921_RS07250	COG0436	Aminotransferase
CR921_RS07255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CR921_RS07260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CR921_RS07265	COG1051	belongs to the nudix hydrolase family
CR921_RS07285	COG0765	amino acid transport
CR921_RS07290	COG1126	abc transporter atp-binding protein
CR921_RS07350	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CR921_RS07355	COG1518	maintenance of DNA repeat elements
CR921_RS07360	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
CR921_RS07365	COG0560	Phosphoserine phosphatase
CR921_RS07375	COG0187	DNA topoisomerase II activity
CR921_RS07385	COG1346	cytolysis
CR921_RS07390	COG1380	Effector of murein hydrolase LrgA
CR921_RS07400	COG1393	Belongs to the ArsC family
CR921_RS07410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CR921_RS07445	COG1177	transmembrane transport
CR921_RS07450	COG1176	ABC-type spermidine putrescine transport system, permease component I
CR921_RS07490	COG0531	amino acid
CR921_RS07495	COG0285	dihydrofolate synthase activity
CR921_RS07500	COG1837	Belongs to the UPF0109 family
CR921_RS07510	COG3615	Tellurite resistance protein tehB
CR921_RS07510	COG0500	methyltransferase
CR921_RS07525	COG0708	Exodeoxyribonuclease III
CR921_RS07540	COG1597	lipid kinase activity
CR921_RS07550	COG4708	membrane
CR921_RS07560	COG0024	Methionine aminopeptidase
CR921_RS07565	COG4109	DRTGG domain
CR921_RS07575	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CR921_RS07580	COG0658	competence protein
CR921_RS07580	COG2333	competence protein COMEC
CR921_RS07585	COG1596	polysaccharide export
CR921_RS07585	COG1555	photosystem II stabilization
CR921_RS07590	COG0204	Acyl-transferase
CR921_RS07595	COG0726	polysaccharide deacetylase
CR921_RS07600	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CR921_RS07610	COG0513	Belongs to the DEAD box helicase family
CR921_RS07630	COG1396	sequence-specific DNA binding
CR921_RS07635	COG2211	Major facilitator Superfamily
CR921_RS07650	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CR921_RS07665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CR921_RS07670	COG1126	abc transporter atp-binding protein
CR921_RS07675	COG0765	amino acid transport
CR921_RS07680	COG0765	amino acid transport
CR921_RS07695	COG2217	Heavy metal translocating P-type atpase
CR921_RS07705	COG0159	tryptophan synthase activity
CR921_RS07715	COG0135	phosphoribosylanthranilate isomerase activity
CR921_RS07730	COG0512	Glutamine amidotransferase of anthranilate synthase
CR921_RS07735	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CR921_RS07740	COG0287	Prephenate dehydrogenase
CR921_RS07740	COG1605	Chorismate mutase
CR921_RS07750	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CR921_RS07775	COG2176	DNA-directed DNA polymerase activity
CR921_RS07785	COG2151	metal-sulfur cluster biosynthetic enzyme
CR921_RS07795	COG2081	HI0933 family
CR921_RS07820	COG1131	(ABC) transporter
CR921_RS07825	COG0537	adenosine 5'-monophosphoramidase activity
CR921_RS07865	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CR921_RS07875	COG2226	methyltransferase
CR921_RS07885	COG0799	negative regulation of ribosome biogenesis
CR921_RS07890	COG1713	HD superfamily hydrolase involved in NAD metabolism
CR921_RS07895	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CR921_RS07900	COG1534	Rna-binding protein
CR921_RS07905	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CR921_RS07910	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CR921_RS07965	COG1335	isochorismatase
CR921_RS07975	COG0436	Aminotransferase
CR921_RS07980	COG0589	response to stress
CR921_RS07995	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CR921_RS08005	COG1253	flavin adenine dinucleotide binding
CR921_RS08010	COG1119	ATPase activity
CR921_RS08015	COG0025	NhaP-type Na H and K H
CR921_RS08025	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CR921_RS08030	COG1242	4 iron, 4 sulfur cluster binding
CR921_RS08035	COG3480	Lon protease (S16) C-terminal proteolytic domain
CR921_RS08040	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CR921_RS08045	COG0742	ribosomal rna small subunit methyltransferase
CR921_RS08050	COG0492	ferredoxin-NADP+ reductase activity
CR921_RS08060	COG1126	abc transporter atp-binding protein
CR921_RS08070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CR921_RS08085	COG1882	Formate acetyltransferase
CR921_RS08115	COG0390	transport system, permease component
CR921_RS08120	COG4619	ABC transporter
CR921_RS08130	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CR921_RS08145	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CR921_RS08155	COG1132	(ABC) transporter
CR921_RS08160	COG1132	(ABC) transporter
CR921_RS08180	COG4470	Protein conserved in bacteria
CR921_RS08185	COG0737	Belongs to the 5'-nucleotidase family
CR921_RS08190	COG0513	Belongs to the DEAD box helicase family
CR921_RS08200	COG0768	penicillin binding
CR921_RS08230	COG3152	Membrane
CR921_RS08235	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CR921_RS08250	COG4152	abc transporter atp-binding protein
CR921_RS08295	COG0561	phosphatase activity
CR921_RS08300	COG0252	asparaginase activity
CR921_RS08305	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CR921_RS08310	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CR921_RS08320	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CR921_RS08325	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CR921_RS08340	COG1482	cell wall glycoprotein biosynthetic process
CR921_RS08345	COG1940	carbohydrate kinase activity
CR921_RS08350	COG2190	(PTS) system
CR921_RS08350	COG1263	PTS System
CR921_RS08350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CR921_RS08355	COG1621	beta-fructofuranosidase activity
CR921_RS08360	COG1609	Transcriptional regulator
CR921_RS08380	COG2131	deaminase
CR921_RS08385	COG0006	proline dipeptidase activity
CR921_RS08400	COG1131	(ABC) transporter
CR921_RS08475	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CR921_RS08475	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CR921_RS08500	COG0681	Belongs to the peptidase S26 family
CR921_RS08505	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CR921_RS08515	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CR921_RS08525	COG0456	acetyltransferase
CR921_RS08530	COG1214	PFAM Peptidase M22, glycoprotease
CR921_RS08550	COG0174	glutamine synthetase
CR921_RS08555	COG0789	Transcriptional regulator
CR921_RS08610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CR921_RS08655	COG0084	hydrolase, TatD family'
CR921_RS08665	COG3118	belongs to the thioredoxin family
CR921_RS08730	COG0706	membrane insertase activity
CR921_RS08795	COG0756	dUTP diphosphatase activity
CR921_RS08825	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CR921_RS08830	COG0705	Rhomboid family
CR921_RS08830	COG0457	Tetratricopeptide repeat
CR921_RS08835	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CR921_RS08855	COG2226	methyltransferase
CR921_RS08885	COG0425	Belongs to the sulfur carrier protein TusA family
CR921_RS08890	COG2391	methyltransferase activity
CR921_RS08895	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CR921_RS08900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CR921_RS08910	COG1363	Peptidase, m42
CR921_RS08915	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CR921_RS08920	COG1266	CAAX protease self-immunity
CR921_RS08980	COG1459	type II secretion system
CR921_RS08985	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CR921_RS09020	COG0440	acetolactate synthase activity
CR921_RS09025	COG0028	Belongs to the TPP enzyme family
CR921_RS09035	COG1461	Dihydroxyacetone kinase
CR921_RS09045	COG0534	Mate efflux family protein
CR921_RS09065	COG1454	alcohol dehydrogenase
CR921_RS09065	COG1012	belongs to the aldehyde dehydrogenase family
CR921_RS09070	COG1012	belongs to the aldehyde dehydrogenase family
CR921_RS09070	COG1454	alcohol dehydrogenase
CR921_RS09075	COG1454	alcohol dehydrogenase
CR921_RS09075	COG1012	belongs to the aldehyde dehydrogenase family
CR921_RS09080	COG1012	belongs to the aldehyde dehydrogenase family
CR921_RS09080	COG1454	alcohol dehydrogenase
CR921_RS09085	COG3590	peptidase
CR921_RS09100	COG1609	Transcriptional regulator
CR921_RS09105	COG2188	Transcriptional regulator
CR921_RS09110	COG4475	Protein of unknown function (DUF436)
CR921_RS09135	COG0191	fructose-bisphosphate aldolase activity
CR921_RS09205	COG0201	protein transport
CR921_RS09350	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CR921_RS09365	COG0515	serine threonine protein kinase
CR921_RS09370	COG1132	(ABC) transporter
CR921_RS09375	COG1396	sequence-specific DNA binding
CR921_RS09385	COG1132	(ABC) transporter
CR921_RS09420	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CR921_RS09470	COG0602	queuosine metabolic process
CR921_RS09480	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CR921_RS09510	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CR921_RS09520	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CR921_RS09550	COG2261	transglycosylase associated protein
CR921_RS09570	COG3237	CsbD-like
CR921_RS09595	COG1511	domain protein
CR921_RS09595	COG1511	domain protein
CR921_RS09605	COG3759	membrane
CR921_RS09620	COG0305	Participates in initiation and elongation during chromosome replication
CR921_RS09650	COG0741	lytic transglycosylase activity
CR921_RS09655	COG1388	LysM domain
CR921_RS09655	COG3584	3D domain protein
CR921_RS09660	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CR921_RS09675	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CR921_RS09685	COG0612	Peptidase, M16
CR921_RS09715	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CR921_RS09720	COG0488	(ABC) transporter
CR921_RS09755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CR921_RS09760	COG1475	DNA binding