locus-tag	class	description
ESP48_RS00025	COG1230	cation diffusion facilitator family transporter
ESP48_RS00035	COG1063	alcohol dehydrogenase
ESP48_RS00065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ESP48_RS00070	COG4607	ABC-type enterochelin transport system periplasmic component
ESP48_RS00090	COG1293	RNA-binding protein homologous to eukaryotic snRNP
ESP48_RS00125	COG0047	phosphoribosylformylglycinamidine synthase activity
ESP48_RS00140	COG0167	dihydroorotate dehydrogenase activity
ESP48_RS00150	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ESP48_RS00170	COG1337	RAMP superfamily
ESP48_RS00175	COG1567	CRISPR-associated RAMP protein, Csm4 family
ESP48_RS00190	COG0284	orotidine-5'-phosphate decarboxylase activity
ESP48_RS00205	COG3104	oligopeptide transport
ESP48_RS00210	COG0154	amidase activity
ESP48_RS00215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ESP48_RS00220	COG0765	amino acid transport
ESP48_RS00255	COG1115	amino acid carrier protein
ESP48_RS00265	COG2873	o-acetylhomoserine
ESP48_RS00300	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ESP48_RS00305	COG0196	riboflavin kinase activity
ESP48_RS00310	COG1393	Belongs to the ArsC family
ESP48_RS00320	COG0483	inositol monophosphate 1-phosphatase activity
ESP48_RS00325	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
ESP48_RS00325	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ESP48_RS00335	COG0573	inorganic phosphate transmembrane transporter activity
ESP48_RS00340	COG0581	inorganic phosphate transmembrane transporter activity
ESP48_RS00355	COG0704	Plays a role in the regulation of phosphate uptake
ESP48_RS00370	COG0095	Lipoate-protein ligase
ESP48_RS00385	COG0058	SHG alpha-glucan phosphorylase activity
ESP48_RS00390	COG1640	4-alpha-glucanotransferase
ESP48_RS00410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ESP48_RS00415	COG0805	protein transport
ESP48_RS00420	COG0672	)-iron permease
ESP48_RS00425	COG2837	iron assimilation
ESP48_RS00430	COG2822	iron ion transport
ESP48_RS00435	COG4607	ABC-type enterochelin transport system periplasmic component
ESP48_RS00440	COG4604	ABC transporter, ATP-binding protein
ESP48_RS00445	COG4605	iron ion homeostasis
ESP48_RS00450	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ESP48_RS00480	COG0508	dehydrogenase complex catalyzes the overall conversion of
ESP48_RS00485	COG0022	dehydrogenase e1 component
ESP48_RS00485	COG0508	dehydrogenase complex catalyzes the overall conversion of
ESP48_RS00490	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ESP48_RS00525	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ESP48_RS00535	COG4667	esterase of the alpha-beta hydrolase superfamily
ESP48_RS00580	COG0628	permease
ESP48_RS00590	COG0561	phosphatase activity
ESP48_RS00620	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ESP48_RS00640	COG0438	transferase activity, transferring glycosyl groups
ESP48_RS00640	COG4641	Protein conserved in bacteria
ESP48_RS00650	COG1216	Glycosyl transferase, family 2
ESP48_RS00650	COG1442	glycosyl transferase family 8
ESP48_RS00690	COG1316	TRANSCRIPTIONal
ESP48_RS00710	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ESP48_RS00720	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ESP48_RS00740	COG1573	uracil-dna glycosylase
ESP48_RS00805	COG0681	Belongs to the peptidase S26 family
ESP48_RS00815	COG0628	permease
ESP48_RS00820	COG1051	belongs to the nudix hydrolase family
ESP48_RS00825	COG2177	Part of the ABC transporter FtsEX involved in
ESP48_RS00830	COG2884	Cell division ATP-binding protein ftsE
ESP48_RS00840	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ESP48_RS00875	COG2348	transferase activity, transferring amino-acyl groups
ESP48_RS00885	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ESP48_RS00890	COG5002	protein histidine kinase activity
ESP48_RS00895	COG0745	RESPONSE REGULATOR receiver
ESP48_RS00900	COG1126	abc transporter atp-binding protein
ESP48_RS00905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ESP48_RS00910	COG0765	amino acid transport
ESP48_RS00915	COG0765	amino acid transport
ESP48_RS00940	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ESP48_RS00955	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ESP48_RS00960	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ESP48_RS00960	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ESP48_RS00970	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ESP48_RS00975	COG1956	GAF domain-containing protein
ESP48_RS00980	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ESP48_RS01000	COG0335	large ribosomal subunit rRNA binding
ESP48_RS01005	COG0038	chloride channel
ESP48_RS01015	COG0038	chloride channel
ESP48_RS01020	COG0716	FMN binding
ESP48_RS01085	COG0469	pyruvate kinase activity
ESP48_RS01135	COG0167	dihydroorotate dehydrogenase activity
ESP48_RS01145	COG0776	regulation of translation
ESP48_RS01155	COG2755	lipolytic protein G-D-S-L family
ESP48_RS01160	COG1307	EDD domain protein, DegV family
ESP48_RS01165	COG0497	DNA recombination
ESP48_RS01170	COG1438	arginine binding
ESP48_RS01175	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ESP48_RS01200	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ESP48_RS01220	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ESP48_RS01220	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ESP48_RS01225	COG0300	oxidoreductase activity
ESP48_RS01240	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ESP48_RS01245	COG0772	Belongs to the SEDS family
ESP48_RS01260	COG0107	imidazoleglycerol-phosphate synthase activity
ESP48_RS01270	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ESP48_RS01280	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ESP48_RS01330	COG0647	UMP catabolic process
ESP48_RS01340	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ESP48_RS01365	COG1088	dTDP-glucose 4,6-dehydratase activity
ESP48_RS01375	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ESP48_RS01380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ESP48_RS01395	COG2384	SAM-dependent methyltransferase
ESP48_RS01420	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ESP48_RS01425	COG3442	glutamine amidotransferase
ESP48_RS01430	COG0392	lysyltransferase activity
ESP48_RS01430	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ESP48_RS01445	COG0488	(ABC) transporter
ESP48_RS01455	COG0513	Belongs to the DEAD box helicase family
ESP48_RS01490	COG0372	Belongs to the citrate synthase family
ESP48_RS01495	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ESP48_RS01500	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ESP48_RS01505	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ESP48_RS01510	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ESP48_RS01535	COG0346	lactoylglutathione lyase activity
ESP48_RS01540	COG3764	Sortase (surface protein transpeptidase)
ESP48_RS01560	COG0488	(ABC) transporter
ESP48_RS01590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ESP48_RS01595	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ESP48_RS01595	COG1328	CTP reductase activity
ESP48_RS01630	COG1196	nuclear chromosome segregation
ESP48_RS01645	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ESP48_RS01665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ESP48_RS01675	COG1011	Hydrolase
ESP48_RS01680	COG1268	BioY protein
ESP48_RS01690	COG0517	IMP dehydrogenase activity
ESP48_RS01690	COG1125	glycine betaine transport
ESP48_RS01705	COG2986	histidine ammonia-lyase
ESP48_RS01715	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ESP48_RS01725	COG2197	response regulator
ESP48_RS01730	COG4585	Histidine kinase
ESP48_RS01740	COG1131	(ABC) transporter
ESP48_RS01775	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ESP48_RS01810	COG0577	efflux transmembrane transporter activity
ESP48_RS01815	COG1136	(ABC) transporter
ESP48_RS01820	COG5002	protein histidine kinase activity
ESP48_RS01820	COG2198	Histidine kinase
ESP48_RS01820	COG0784	Response regulator, receiver
ESP48_RS01825	COG0745	RESPONSE REGULATOR receiver
ESP48_RS01840	COG0534	Mate efflux family protein
ESP48_RS01845	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ESP48_RS01845	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ESP48_RS01880	COG0531	amino acid
ESP48_RS01890	COG2514	catechol 2,3-dioxygenase activity
ESP48_RS01895	COG1959	2 iron, 2 sulfur cluster binding
ESP48_RS01905	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ESP48_RS01905	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ESP48_RS01910	COG0778	Nitroreductase
ESP48_RS01920	COG0656	L-ascorbic acid biosynthetic process
ESP48_RS01925	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ESP48_RS01965	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ESP48_RS01990	COG1280	lysine exporter protein (LysE YggA)
ESP48_RS02005	COG1442	glycosyl transferase family 8
ESP48_RS02005	COG1216	Glycosyl transferase, family 2
ESP48_RS02020	COG0577	efflux transmembrane transporter activity
ESP48_RS02080	COG1396	sequence-specific DNA binding
ESP48_RS02095	COG0419	ATPase involved in DNA repair
ESP48_RS02100	COG0420	3'-5' exonuclease activity
ESP48_RS02110	COG3250	beta-galactosidase activity
ESP48_RS02115	COG2211	Major facilitator Superfamily
ESP48_RS02115	COG2190	(PTS) system
ESP48_RS02120	COG2017	converts alpha-aldose to the beta-anomer
ESP48_RS02125	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ESP48_RS02140	COG1609	Transcriptional regulator
ESP48_RS02165	COG0488	(ABC) transporter
ESP48_RS02230	COG2197	response regulator
ESP48_RS02235	COG4585	Histidine kinase
ESP48_RS02250	COG0515	serine threonine protein kinase
ESP48_RS02250	COG2815	serine threonine protein kinase
ESP48_RS02260	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ESP48_RS02260	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ESP48_RS02270	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ESP48_RS02285	COG0552	protein localization to endoplasmic reticulum
ESP48_RS02290	COG0561	phosphatase activity
ESP48_RS02295	COG0561	phosphatase activity
ESP48_RS02300	COG1725	Transcriptional regulator
ESP48_RS02305	COG1131	(ABC) transporter
ESP48_RS02315	COG4608	Belongs to the ABC transporter superfamily
ESP48_RS02320	COG0444	Belongs to the ABC transporter superfamily
ESP48_RS02325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ESP48_RS02330	COG0601	transmembrane transport
ESP48_RS02335	COG4166	transmembrane transport
ESP48_RS02345	COG4608	Belongs to the ABC transporter superfamily
ESP48_RS02355	COG0084	hydrolase, TatD family'
ESP48_RS02360	COG2223	nitrite transmembrane transporter activity
ESP48_RS02370	COG0280	phosphate acetyltransferase
ESP48_RS02375	COG0564	pseudouridine synthase activity
ESP48_RS02385	COG2357	RelA SpoT domain protein
ESP48_RS02400	COG1104	cysteine desulfurase activity
ESP48_RS02415	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ESP48_RS02450	COG1215	transferase activity, transferring glycosyl groups
ESP48_RS02470	COG0463	Glycosyl transferase, family 2
ESP48_RS02475	COG1216	Glycosyl transferase, family 2
ESP48_RS02480	COG1216	Glycosyl transferase, family 2
ESP48_RS02490	COG1091	dTDP-4-dehydrorhamnose reductase activity
ESP48_RS02500	COG0463	Glycosyl transferase, family 2
ESP48_RS02505	COG2151	metal-sulfur cluster biosynthetic enzyme
ESP48_RS02510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ESP48_RS02515	COG0358	DNA primase activity
ESP48_RS02530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ESP48_RS02535	COG0436	Aminotransferase
ESP48_RS02540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ESP48_RS02545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ESP48_RS02550	COG1051	belongs to the nudix hydrolase family
ESP48_RS02570	COG0765	amino acid transport
ESP48_RS02575	COG1126	abc transporter atp-binding protein
ESP48_RS02635	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ESP48_RS02640	COG1518	maintenance of DNA repeat elements
ESP48_RS02645	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
ESP48_RS02650	COG0560	Phosphoserine phosphatase
ESP48_RS02660	COG0187	DNA topoisomerase II activity
ESP48_RS02670	COG1346	cytolysis
ESP48_RS02675	COG1380	Effector of murein hydrolase LrgA
ESP48_RS02685	COG1393	Belongs to the ArsC family
ESP48_RS02695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ESP48_RS02730	COG1177	transmembrane transport
ESP48_RS02735	COG1176	ABC-type spermidine putrescine transport system, permease component I
ESP48_RS02775	COG0531	amino acid
ESP48_RS02780	COG0285	dihydrofolate synthase activity
ESP48_RS02785	COG1837	Belongs to the UPF0109 family
ESP48_RS02795	COG0500	methyltransferase
ESP48_RS02795	COG3615	Tellurite resistance protein tehB
ESP48_RS02805	COG0708	Exodeoxyribonuclease III
ESP48_RS02820	COG1597	lipid kinase activity
ESP48_RS02830	COG4708	membrane
ESP48_RS02840	COG0024	Methionine aminopeptidase
ESP48_RS02845	COG4109	DRTGG domain
ESP48_RS02855	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ESP48_RS02860	COG0658	competence protein
ESP48_RS02860	COG2333	competence protein COMEC
ESP48_RS02865	COG1555	photosystem II stabilization
ESP48_RS02865	COG1596	polysaccharide export
ESP48_RS02870	COG0204	Acyl-transferase
ESP48_RS02880	COG0726	polysaccharide deacetylase
ESP48_RS02885	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ESP48_RS02895	COG0513	Belongs to the DEAD box helicase family
ESP48_RS02915	COG1396	sequence-specific DNA binding
ESP48_RS02935	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ESP48_RS02950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ESP48_RS02955	COG1126	abc transporter atp-binding protein
ESP48_RS02960	COG0765	amino acid transport
ESP48_RS02965	COG0765	amino acid transport
ESP48_RS02970	COG1181	Belongs to the D-alanine--D-alanine ligase family
ESP48_RS02980	COG2217	Heavy metal translocating P-type atpase
ESP48_RS02990	COG0159	tryptophan synthase activity
ESP48_RS03000	COG0135	phosphoribosylanthranilate isomerase activity
ESP48_RS03015	COG0512	Glutamine amidotransferase of anthranilate synthase
ESP48_RS03020	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ESP48_RS03025	COG0287	Prephenate dehydrogenase
ESP48_RS03025	COG1605	Chorismate mutase
ESP48_RS03035	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ESP48_RS03060	COG2176	DNA-directed DNA polymerase activity
ESP48_RS03070	COG2151	metal-sulfur cluster biosynthetic enzyme
ESP48_RS03080	COG2081	HI0933 family
ESP48_RS03105	COG1131	(ABC) transporter
ESP48_RS03110	COG0537	adenosine 5'-monophosphoramidase activity
ESP48_RS03140	COG2226	methyltransferase
ESP48_RS03150	COG0799	negative regulation of ribosome biogenesis
ESP48_RS03155	COG1713	HD superfamily hydrolase involved in NAD metabolism
ESP48_RS03160	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ESP48_RS03165	COG1534	Rna-binding protein
ESP48_RS03170	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ESP48_RS03175	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
ESP48_RS03230	COG1335	isochorismatase
ESP48_RS03240	COG0436	Aminotransferase
ESP48_RS03245	COG0589	response to stress
ESP48_RS03260	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ESP48_RS03270	COG1253	flavin adenine dinucleotide binding
ESP48_RS03275	COG1119	ATPase activity
ESP48_RS03280	COG0025	NhaP-type Na H and K H
ESP48_RS03290	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ESP48_RS03295	COG1242	4 iron, 4 sulfur cluster binding
ESP48_RS03300	COG3480	Lon protease (S16) C-terminal proteolytic domain
ESP48_RS03305	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ESP48_RS03310	COG0742	ribosomal rna small subunit methyltransferase
ESP48_RS03315	COG0492	ferredoxin-NADP+ reductase activity
ESP48_RS03325	COG1126	abc transporter atp-binding protein
ESP48_RS03335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ESP48_RS03350	COG1882	Formate acetyltransferase
ESP48_RS03380	COG0390	transport system, permease component
ESP48_RS03385	COG4619	ABC transporter
ESP48_RS03390	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ESP48_RS03405	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ESP48_RS03480	COG3290	protein histidine kinase activity
ESP48_RS03490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ESP48_RS03495	COG2274	protein secretion by the type I secretion system
ESP48_RS03510	COG1132	(ABC) transporter
ESP48_RS03515	COG1132	(ABC) transporter
ESP48_RS03530	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ESP48_RS03535	COG4470	Protein conserved in bacteria
ESP48_RS03540	COG0737	Belongs to the 5'-nucleotidase family
ESP48_RS03545	COG0513	Belongs to the DEAD box helicase family
ESP48_RS03555	COG0768	penicillin binding
ESP48_RS03590	COG3152	Membrane
ESP48_RS03600	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ESP48_RS03615	COG4152	abc transporter atp-binding protein
ESP48_RS03620	COG1811	Na channel or pump
ESP48_RS03630	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ESP48_RS03660	COG0561	phosphatase activity
ESP48_RS03665	COG0252	asparaginase activity
ESP48_RS03670	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ESP48_RS03685	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ESP48_RS03690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ESP48_RS03705	COG1482	cell wall glycoprotein biosynthetic process
ESP48_RS03710	COG1940	carbohydrate kinase activity
ESP48_RS03715	COG2190	(PTS) system
ESP48_RS03715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ESP48_RS03715	COG1263	PTS System
ESP48_RS03720	COG1621	beta-fructofuranosidase activity
ESP48_RS03725	COG1609	Transcriptional regulator
ESP48_RS03740	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ESP48_RS03745	COG2131	deaminase
ESP48_RS03750	COG0006	proline dipeptidase activity
ESP48_RS03765	COG1131	(ABC) transporter
ESP48_RS03840	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ESP48_RS03840	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ESP48_RS03865	COG0681	Belongs to the peptidase S26 family
ESP48_RS03870	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ESP48_RS03880	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ESP48_RS03890	COG0456	acetyltransferase
ESP48_RS03895	COG1214	PFAM Peptidase M22, glycoprotease
ESP48_RS03915	COG0174	glutamine synthetase
ESP48_RS03920	COG0789	Transcriptional regulator
ESP48_RS03975	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ESP48_RS04020	COG0084	hydrolase, TatD family'
ESP48_RS04025	COG1832	CoA-binding protein
ESP48_RS04030	COG3118	belongs to the thioredoxin family
ESP48_RS04100	COG0706	membrane insertase activity
ESP48_RS04125	COG4166	transmembrane transport
ESP48_RS04130	COG4166	transmembrane transport
ESP48_RS04165	COG0756	dUTP diphosphatase activity
ESP48_RS04195	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ESP48_RS04200	COG0705	Rhomboid family
ESP48_RS04200	COG0457	Tetratricopeptide repeat
ESP48_RS04205	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ESP48_RS04225	COG2226	methyltransferase
ESP48_RS04255	COG0425	Belongs to the sulfur carrier protein TusA family
ESP48_RS04260	COG2391	methyltransferase activity
ESP48_RS04265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ESP48_RS04270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ESP48_RS04280	COG1363	Peptidase, m42
ESP48_RS04285	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ESP48_RS04290	COG1266	CAAX protease self-immunity
ESP48_RS04350	COG1459	type II secretion system
ESP48_RS04355	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ESP48_RS04390	COG0440	acetolactate synthase activity
ESP48_RS04395	COG0028	Belongs to the TPP enzyme family
ESP48_RS04405	COG1461	Dihydroxyacetone kinase
ESP48_RS04415	COG0534	Mate efflux family protein
ESP48_RS04430	COG1454	alcohol dehydrogenase
ESP48_RS04430	COG1012	belongs to the aldehyde dehydrogenase family
ESP48_RS04435	COG1012	belongs to the aldehyde dehydrogenase family
ESP48_RS04435	COG1454	alcohol dehydrogenase
ESP48_RS04440	COG1454	alcohol dehydrogenase
ESP48_RS04440	COG1012	belongs to the aldehyde dehydrogenase family
ESP48_RS04445	COG1012	belongs to the aldehyde dehydrogenase family
ESP48_RS04445	COG1454	alcohol dehydrogenase
ESP48_RS04450	COG3590	peptidase
ESP48_RS04465	COG1609	Transcriptional regulator
ESP48_RS04470	COG2188	Transcriptional regulator
ESP48_RS04475	COG4475	Protein of unknown function (DUF436)
ESP48_RS04495	COG0191	fructose-bisphosphate aldolase activity
ESP48_RS04555	COG0201	protein transport
ESP48_RS04695	COG1396	sequence-specific DNA binding
ESP48_RS04700	COG1396	sequence-specific DNA binding
ESP48_RS04710	COG1132	(ABC) transporter
ESP48_RS04745	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ESP48_RS04790	COG0602	queuosine metabolic process
ESP48_RS04800	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ESP48_RS04835	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ESP48_RS04865	COG2261	transglycosylase associated protein
ESP48_RS04885	COG3237	CsbD-like
ESP48_RS04935	COG1511	domain protein
ESP48_RS04935	COG1511	domain protein
ESP48_RS04945	COG3759	membrane
ESP48_RS04960	COG0305	Participates in initiation and elongation during chromosome replication
ESP48_RS04980	COG0494	nUDIX hydrolase
ESP48_RS05000	COG0741	lytic transglycosylase activity
ESP48_RS05005	COG3584	3D domain protein
ESP48_RS05005	COG1388	LysM domain
ESP48_RS05010	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ESP48_RS05025	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ESP48_RS05035	COG0612	Peptidase, M16
ESP48_RS05065	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ESP48_RS05070	COG0488	(ABC) transporter
ESP48_RS05105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ESP48_RS05110	COG1475	DNA binding
ESP48_RS05120	COG0592	DNA-directed DNA polymerase activity
ESP48_RS05130	COG0012	GTP binding
ESP48_RS05140	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ESP48_RS05145	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ESP48_RS05175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ESP48_RS05305	COG3942	CHAP domain
ESP48_RS05320	COG0436	Aminotransferase
ESP48_RS05335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ESP48_RS05345	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ESP48_RS05350	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ESP48_RS05360	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ESP48_RS05375	COG1388	LysM domain
ESP48_RS05375	COG3942	CHAP domain
ESP48_RS05380	COG0151	Belongs to the GarS family
ESP48_RS05385	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ESP48_RS05405	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ESP48_RS05420	COG4550	Control of competence regulator ComK, YlbF/YmcA
ESP48_RS05460	COG2818	Glycosylase
ESP48_RS05475	COG1393	Belongs to the ArsC family
ESP48_RS05565	COG2309	aminopeptidase activity
ESP48_RS05580	COG0431	NADPH-dependent FMN reductase
ESP48_RS05620	COG4463	regulation of RNA biosynthetic process
ESP48_RS05625	COG0542	response to heat
ESP48_RS05640	COG1686	Belongs to the peptidase S11 family
ESP48_RS05655	COG1045	serine acetyltransferase
ESP48_RS05665	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
ESP48_RS05680	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ESP48_RS05705	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ESP48_RS05755	COG2189	Belongs to the N(4) N(6)-methyltransferase family
ESP48_RS05760	COG3421	Type III restriction
ESP48_RS05800	COG3830	Belongs to the UPF0237 family
ESP48_RS05815	COG1876	peptidase activity
ESP48_RS05850	COG0351	phosphomethylpyrimidine kinase
ESP48_RS05970	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ESP48_RS05990	COG0668	transmembrane transport
ESP48_RS06005	COG0504	CTP synthase activity
ESP48_RS06015	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ESP48_RS06025	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ESP48_RS06030	COG0737	Belongs to the 5'-nucleotidase family
ESP48_RS06065	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ESP48_RS06100	COG1126	abc transporter atp-binding protein
ESP48_RS06105	COG0765	amino acid transport
ESP48_RS06125	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ESP48_RS06135	COG0719	Fe-S assembly protein
ESP48_RS06140	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ESP48_RS06150	COG0719	Fe-S assembly protein
ESP48_RS06175	COG4608	Belongs to the ABC transporter superfamily
ESP48_RS06190	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ESP48_RS06205	COG1121	(ABC) transporter
ESP48_RS06210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ESP48_RS06250	COG4589	Belongs to the CDS family
ESP48_RS06265	COG4120	Belongs to the binding-protein-dependent transport system permease family
ESP48_RS06270	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ESP48_RS06270	COG1116	anion transmembrane transporter activity
ESP48_RS06305	COG0564	pseudouridine synthase activity
ESP48_RS06310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ESP48_RS06340	COG1349	DNA-binding transcription factor activity
ESP48_RS06370	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ESP48_RS06385	COG3579	cysteine-type endopeptidase activity
ESP48_RS06390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ESP48_RS06415	COG0116	Belongs to the methyltransferase superfamily
ESP48_RS06425	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ESP48_RS06445	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ESP48_RS06470	COG1254	Belongs to the acylphosphatase family
ESP48_RS06475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ESP48_RS06520	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ESP48_RS06540	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ESP48_RS06545	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ESP48_RS06550	COG1187	pseudouridine synthase activity
ESP48_RS06560	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ESP48_RS06565	COG0569	domain protein
ESP48_RS06575	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
ESP48_RS06580	COG0671	phosphoesterase, PA-phosphatase related
ESP48_RS06600	COG2274	protein secretion by the type I secretion system
ESP48_RS06605	COG2274	protein secretion by the type I secretion system
ESP48_RS06610	COG2274	protein secretion by the type I secretion system
ESP48_RS06660	COG0829	nickel cation binding
ESP48_RS06665	COG0310	cobalt ion transport
ESP48_RS06675	COG1122	ATPase activity
ESP48_RS06680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ESP48_RS06685	COG1464	Belongs to the NlpA lipoprotein family
ESP48_RS06695	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ESP48_RS06720	COG1122	ATPase activity
ESP48_RS06730	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ESP48_RS06745	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ESP48_RS06760	COG0745	RESPONSE REGULATOR receiver
ESP48_RS06765	COG5002	protein histidine kinase activity
ESP48_RS06780	COG1484	DNA-dependent DNA replication
ESP48_RS06820	COG3716	PTS system mannose fructose sorbose family IID component
ESP48_RS06825	COG3715	PTS system
ESP48_RS06835	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ESP48_RS06840	COG0561	phosphatase activity
ESP48_RS06845	COG2252	PERMEase
ESP48_RS06850	COG0802	atpase or kinase
ESP48_RS06855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ESP48_RS06860	COG1316	TRANSCRIPTIONal
ESP48_RS06870	COG0195	Participates in both transcription termination and antitermination
ESP48_RS06875	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ESP48_RS06895	COG1611	Belongs to the LOG family
ESP48_RS06915	COG2244	polysaccharide biosynthetic process
ESP48_RS06920	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ESP48_RS06925	COG0626	cystathionine gamma-synthase activity
ESP48_RS06930	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ESP48_RS06960	COG4471	UPF0298 protein
ESP48_RS06970	COG0559	Belongs to the binding-protein-dependent transport system permease family
ESP48_RS07000	COG1739	Uncharacterized protein family UPF0029
ESP48_RS07005	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
ESP48_RS07010	COG1040	competence protein
ESP48_RS07100	COG0527	aspartate kinase activity
ESP48_RS07105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ESP48_RS07110	COG1024	Enoyl-CoA hydratase
ESP48_RS07115	COG1846	Transcriptional regulator
ESP48_RS07135	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ESP48_RS07140	COG1028	Short-chain dehydrogenase reductase Sdr
ESP48_RS07145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ESP48_RS07160	COG0439	Biotin carboxylase
ESP48_RS07200	COG1349	DNA-binding transcription factor activity
ESP48_RS07205	COG1105	Belongs to the carbohydrate kinase PfkB family
ESP48_RS07215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ESP48_RS07220	COG0285	dihydrofolate synthase activity
ESP48_RS07230	COG1104	cysteine desulfurase activity
ESP48_RS07290	COG0488	(ABC) transporter
ESP48_RS07310	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ESP48_RS07315	COG0242	peptide deformylase activity
ESP48_RS07375	COG1702	phosphate starvation-inducible protein PhoH
ESP48_RS07395	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ESP48_RS07395	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ESP48_RS07425	COG4122	O-methyltransferase activity
ESP48_RS07430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ESP48_RS07460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ESP48_RS07465	COG0436	Aminotransferase
ESP48_RS07480	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ESP48_RS07485	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ESP48_RS07490	COG0726	polysaccharide deacetylase
ESP48_RS07505	COG2962	Rard protein
ESP48_RS07545	COG0356	it plays a direct role in the translocation of protons across the membrane
ESP48_RS07580	COG0772	Belongs to the SEDS family
ESP48_RS07600	COG0470	DNA polymerase III
ESP48_RS07605	COG1774	PSP1 C-terminal conserved region
ESP48_RS07610	COG4467	Involved in initiation control of chromosome replication
ESP48_RS07620	COG0004	ammonium transporteR
ESP48_RS07625	COG0347	Belongs to the P(II) protein family
ESP48_RS07630	COG1705	Flagellar rod assembly protein muramidase FlgJ
ESP48_RS07630	COG1388	LysM domain
ESP48_RS07675	COG1113	amino acid transport
ESP48_RS07685	COG1263	PTS System
ESP48_RS07685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ESP48_RS07685	COG2190	(PTS) system
ESP48_RS07725	COG0583	DNA-binding transcription factor activity
ESP48_RS07735	COG0564	pseudouridine synthase activity
ESP48_RS07755	COG0505	Belongs to the CarA family
ESP48_RS07810	COG0577	efflux transmembrane transporter activity
ESP48_RS07865	COG3279	Response regulator of the LytR AlgR family
ESP48_RS07875	COG1131	(ABC) transporter
ESP48_RS07910	COG1187	pseudouridine synthase activity
ESP48_RS07915	COG1473	amidohydrolase
ESP48_RS07920	COG0686	Belongs to the AlaDH PNT family
ESP48_RS07925	COG0686	Belongs to the AlaDH PNT family
ESP48_RS07935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ESP48_RS08000	COG0438	transferase activity, transferring glycosyl groups
ESP48_RS08035	COG1272	protein, Hemolysin III
ESP48_RS08055	COG3425	synthase
ESP48_RS08065	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ESP48_RS08085	COG0833	amino acid
ESP48_RS08090	COG2040	homocysteine
ESP48_RS08110	COG0187	DNA topoisomerase II activity
ESP48_RS08120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ESP48_RS08140	COG0539	negative regulation of cytoplasmic translation
ESP48_RS08180	COG0494	nUDIX hydrolase
ESP48_RS08185	COG0542	response to heat
ESP48_RS08190	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ESP48_RS08195	COG4703	Protein of unknown function (DUF1797)
ESP48_RS08200	COG0765	amino acid transport
ESP48_RS08250	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ESP48_RS08255	COG0768	penicillin binding
ESP48_RS08280	COG3711	transcriptional antiterminator
ESP48_RS08290	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ESP48_RS08295	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ESP48_RS08300	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ESP48_RS08305	COG0237	dephospho-CoA kinase activity
ESP48_RS08325	COG0557	exoribonuclease II activity
ESP48_RS08340	COG1185	polyribonucleotide nucleotidyltransferase activity
ESP48_RS08345	COG0006	proline dipeptidase activity
ESP48_RS08350	COG1609	Transcriptional regulator
ESP48_RS08385	COG1368	sulfuric ester hydrolase activity
ESP48_RS08390	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ESP48_RS08415	COG0287	Prephenate dehydrogenase
ESP48_RS08440	COG0077	Prephenate dehydratase
ESP48_RS08500	COG1518	maintenance of DNA repeat elements
ESP48_RS08505	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ESP48_RS08515	COG3689	TIGRFAM TIGR03943 family protein
ESP48_RS08520	COG0701	Predicted permease
ESP48_RS08525	COG2183	response to ionizing radiation
ESP48_RS08570	COG0826	peptidase U32
ESP48_RS08580	COG1268	BioY protein
ESP48_RS08590	COG4443	Transcriptional Coactivator p15 (PC4)
ESP48_RS08595	COG1914	H( )-stimulated, divalent metal cation uptake system
ESP48_RS08605	COG0494	nUDIX hydrolase
ESP48_RS08620	COG1388	LysM domain
ESP48_RS08620	COG1705	Flagellar rod assembly protein muramidase FlgJ
ESP48_RS08640	COG0406	alpha-ribazole phosphatase activity
ESP48_RS08645	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ESP48_RS08675	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ESP48_RS08705	COG1704	LemA family
ESP48_RS08735	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ESP48_RS08745	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ESP48_RS08750	COG0783	Belongs to the Dps family
ESP48_RS08755	COG0735	belongs to the Fur family
ESP48_RS08760	COG4483	Protein conserved in bacteria
ESP48_RS08765	COG1940	carbohydrate kinase activity
ESP48_RS08770	COG1217	gtp-binding protein TYPA
ESP48_RS08795	COG0849	cell division
ESP48_RS08805	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ESP48_RS08830	COG3599	regulation of cell shape
ESP48_RS08865	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ESP48_RS08870	COG0625	glutathione transferase activity
ESP48_RS08880	COG1435	thymidine kinase activity
ESP48_RS08890	COG2890	protein-(glutamine-N5) methyltransferase activity
ESP48_RS08920	COG1132	(ABC) transporter
ESP48_RS08935	COG1696	Membrane protein involved in D-alanine export
ESP48_RS08945	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
ESP48_RS08955	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ESP48_RS08960	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ESP48_RS08980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ESP48_RS08985	COG4684	Psort location CytoplasmicMembrane, score
ESP48_RS08990	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ESP48_RS09015	COG5002	protein histidine kinase activity
ESP48_RS09020	COG5002	protein histidine kinase activity
ESP48_RS09025	COG5002	protein histidine kinase activity
ESP48_RS09050	COG0038	chloride channel
ESP48_RS09085	COG2813	Specifically methylates the guanine in position
ESP48_RS09105	COG0295	cytidine deaminase activity
ESP48_RS09110	COG1744	ABC transporter substrate-binding protein PnrA-like
ESP48_RS09115	COG3845	ABC transporter
ESP48_RS09120	COG4603	Belongs to the binding-protein-dependent transport system permease family
ESP48_RS09125	COG1079	Belongs to the binding-protein-dependent transport system permease family
ESP48_RS09135	COG1199	ATP-dependent helicase activity
ESP48_RS09135	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ESP48_RS09145	COG0436	Aminotransferase
ESP48_RS09165	COG0251	oxidation-reduction process
ESP48_RS09175	COG0720	synthase
ESP48_RS09230	COG1278	Cold shock
ESP48_RS09240	COG3328	transposase activity
ESP48_RS09245	COG2217	Heavy metal translocating P-type atpase
ESP48_RS09250	COG3328	transposase activity
ESP48_RS09265	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ESP48_RS09270	COG0626	cystathionine gamma-synthase activity
ESP48_RS09275	COG1045	serine acetyltransferase
ESP48_RS09295	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ESP48_RS09305	COG4975	Glucose uptake
ESP48_RS09330	COG0803	Belongs to the bacterial solute-binding protein 9 family
ESP48_RS09330	COG3443	Belongs to the bacterial solute-binding protein 9 family
ESP48_RS09350	COG3942	CHAP domain
ESP48_RS09350	COG1705	Flagellar rod assembly protein muramidase FlgJ
ESP48_RS09365	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ESP48_RS09370	COG2824	Alkylphosphonate utilization operon protein PhnA
ESP48_RS09375	COG0765	amino acid transport
ESP48_RS09380	COG1126	abc transporter atp-binding protein
ESP48_RS09385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ESP48_RS09395	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ESP48_RS09410	COG1064	alcohol dehydrogenase
ESP48_RS09415	COG1064	alcohol dehydrogenase
ESP48_RS09425	COG3421	Type III restriction
ESP48_RS09430	COG2189	Belongs to the N(4) N(6)-methyltransferase family
ESP48_RS09435	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ESP48_RS09435	COG0519	Catalyzes the synthesis of GMP from XMP
ESP48_RS09440	COG2188	Transcriptional regulator
ESP48_RS09450	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ESP48_RS09470	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ESP48_RS09480	COG1940	carbohydrate kinase activity
ESP48_RS09485	COG0758	DNA mediated transformation
ESP48_RS09490	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ESP48_RS09535	COG0481	GTPase activity
ESP48_RS09545	COG1396	sequence-specific DNA binding
ESP48_RS09555	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ESP48_RS09560	COG0010	Belongs to the arginase family
ESP48_RS09570	COG0028	Belongs to the TPP enzyme family
ESP48_RS09575	COG3527	Alpha-acetolactate decarboxylase