locus-tag	class	description
A9497_RS00030	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A9497_RS00040	COG0783	Belongs to the Dps family
A9497_RS00045	COG0735	belongs to the Fur family
A9497_RS00050	COG4483	Protein conserved in bacteria
A9497_RS00055	COG1940	carbohydrate kinase activity
A9497_RS00060	COG1217	gtp-binding protein TYPA
A9497_RS00085	COG0849	cell division
A9497_RS00095	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A9497_RS00115	COG3599	regulation of cell shape
A9497_RS00150	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A9497_RS00155	COG0625	glutathione transferase activity
A9497_RS00165	COG1435	thymidine kinase activity
A9497_RS00175	COG2890	protein-(glutamine-N5) methyltransferase activity
A9497_RS00205	COG1132	(ABC) transporter
A9497_RS00220	COG1696	Membrane protein involved in D-alanine export
A9497_RS00230	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A9497_RS00235	COG2801	Transposase and inactivated derivatives
A9497_RS00240	COG2801	Transposase and inactivated derivatives
A9497_RS00260	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A9497_RS00265	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A9497_RS00320	COG1396	sequence-specific DNA binding
A9497_RS00325	COG0582	viral genome integration into host DNA
A9497_RS00345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A9497_RS00350	COG4684	Psort location CytoplasmicMembrane, score
A9497_RS00355	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A9497_RS00380	COG5002	protein histidine kinase activity
A9497_RS00385	COG5002	protein histidine kinase activity
A9497_RS00395	COG2801	Transposase and inactivated derivatives
A9497_RS00415	COG0038	chloride channel
A9497_RS00435	COG2801	Transposase and inactivated derivatives
A9497_RS00455	COG2813	Specifically methylates the guanine in position
A9497_RS00475	COG0295	cytidine deaminase activity
A9497_RS00480	COG1744	ABC transporter substrate-binding protein PnrA-like
A9497_RS00485	COG3845	ABC transporter
A9497_RS00490	COG4603	Belongs to the binding-protein-dependent transport system permease family
A9497_RS00495	COG1079	Belongs to the binding-protein-dependent transport system permease family
A9497_RS00505	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A9497_RS00505	COG1199	ATP-dependent helicase activity
A9497_RS00515	COG0436	Aminotransferase
A9497_RS00540	COG0251	oxidation-reduction process
A9497_RS00550	COG0720	synthase
A9497_RS00595	COG1278	Cold shock
A9497_RS00605	COG2801	Transposase and inactivated derivatives
A9497_RS00620	COG2217	Heavy metal translocating P-type atpase
A9497_RS00635	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A9497_RS00640	COG0626	cystathionine gamma-synthase activity
A9497_RS00645	COG1045	serine acetyltransferase
A9497_RS00655	COG4975	Glucose uptake
A9497_RS00675	COG3443	Belongs to the bacterial solute-binding protein 9 family
A9497_RS00675	COG0803	Belongs to the bacterial solute-binding protein 9 family
A9497_RS00695	COG3942	CHAP domain
A9497_RS00695	COG1705	Flagellar rod assembly protein muramidase FlgJ
A9497_RS00710	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A9497_RS00715	COG2824	Alkylphosphonate utilization operon protein PhnA
A9497_RS00720	COG0765	amino acid transport
A9497_RS00725	COG1126	abc transporter atp-binding protein
A9497_RS00730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A9497_RS00750	COG1064	alcohol dehydrogenase
A9497_RS00765	COG2189	Belongs to the N(4) N(6)-methyltransferase family
A9497_RS00770	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A9497_RS00770	COG0519	Catalyzes the synthesis of GMP from XMP
A9497_RS00775	COG2188	Transcriptional regulator
A9497_RS00785	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A9497_RS00795	COG1827	regulation of RNA biosynthetic process
A9497_RS00805	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A9497_RS00815	COG1940	carbohydrate kinase activity
A9497_RS00820	COG0758	DNA mediated transformation
A9497_RS00825	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A9497_RS00875	COG1396	sequence-specific DNA binding
A9497_RS00885	COG3328	transposase activity
A9497_RS00890	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A9497_RS00895	COG0010	Belongs to the arginase family
A9497_RS00905	COG0028	Belongs to the TPP enzyme family
A9497_RS00910	COG3527	Alpha-acetolactate decarboxylase
A9497_RS00945	COG1230	cation diffusion facilitator family transporter
A9497_RS00955	COG1063	alcohol dehydrogenase
A9497_RS00980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A9497_RS01000	COG1293	RNA-binding protein homologous to eukaryotic snRNP
A9497_RS01010	COG0047	phosphoribosylformylglycinamidine synthase activity
A9497_RS01020	COG0167	dihydroorotate dehydrogenase activity
A9497_RS01025	COG1518	maintenance of DNA repeat elements
A9497_RS01025	COG1468	defense response to virus
A9497_RS01030	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
A9497_RS01050	COG1337	RAMP superfamily
A9497_RS01055	COG1567	CRISPR-associated RAMP protein, Csm4 family
A9497_RS01070	COG0284	orotidine-5'-phosphate decarboxylase activity
A9497_RS01085	COG3104	oligopeptide transport
A9497_RS01100	COG0737	Belongs to the 5'-nucleotidase family
A9497_RS01125	COG1115	amino acid carrier protein
A9497_RS01135	COG2873	o-acetylhomoserine
A9497_RS01165	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A9497_RS01170	COG0196	riboflavin kinase activity
A9497_RS01175	COG1393	Belongs to the ArsC family
A9497_RS01185	COG0483	inositol monophosphate 1-phosphatase activity
A9497_RS01190	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A9497_RS01190	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A9497_RS01200	COG0573	inorganic phosphate transmembrane transporter activity
A9497_RS01205	COG0581	inorganic phosphate transmembrane transporter activity
A9497_RS01220	COG0704	Plays a role in the regulation of phosphate uptake
A9497_RS01235	COG0095	Lipoate-protein ligase
A9497_RS01250	COG0058	SHG alpha-glucan phosphorylase activity
A9497_RS01255	COG1640	4-alpha-glucanotransferase
A9497_RS01270	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A9497_RS01275	COG0805	protein transport
A9497_RS01280	COG0672	)-iron permease
A9497_RS01285	COG2837	iron assimilation
A9497_RS01290	COG2822	iron ion transport
A9497_RS01295	COG4607	ABC-type enterochelin transport system periplasmic component
A9497_RS01300	COG4604	ABC transporter, ATP-binding protein
A9497_RS01305	COG4605	iron ion homeostasis
A9497_RS01310	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A9497_RS01320	COG1523	belongs to the glycosyl hydrolase 13 family
A9497_RS01330	COG1523	belongs to the glycosyl hydrolase 13 family
A9497_RS01360	COG0508	dehydrogenase complex catalyzes the overall conversion of
A9497_RS01365	COG0508	dehydrogenase complex catalyzes the overall conversion of
A9497_RS01365	COG0022	dehydrogenase e1 component
A9497_RS01370	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A9497_RS01390	COG1518	maintenance of DNA repeat elements
A9497_RS01405	COG1857	crispr-associated protein
A9497_RS01440	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A9497_RS01450	COG4667	esterase of the alpha-beta hydrolase superfamily
A9497_RS01480	COG0628	permease
A9497_RS01505	COG0562	UDP-galactopyranose mutase
A9497_RS01515	COG2244	polysaccharide biosynthetic process
A9497_RS01520	COG1442	glycosyl transferase family 8
A9497_RS01520	COG1216	Glycosyl transferase, family 2
A9497_RS01535	COG1216	Glycosyl transferase, family 2
A9497_RS01535	COG1442	glycosyl transferase family 8
A9497_RS01580	COG1316	TRANSCRIPTIONal
A9497_RS01585	COG3328	transposase activity
A9497_RS01605	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A9497_RS01615	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A9497_RS01635	COG1573	uracil-dna glycosylase
A9497_RS01690	COG0681	Belongs to the peptidase S26 family
A9497_RS01700	COG0628	permease
A9497_RS01705	COG1051	belongs to the nudix hydrolase family
A9497_RS01710	COG2177	Part of the ABC transporter FtsEX involved in
A9497_RS01715	COG2884	Cell division ATP-binding protein ftsE
A9497_RS01720	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A9497_RS01725	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A9497_RS01760	COG2348	transferase activity, transferring amino-acyl groups
A9497_RS01770	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A9497_RS01775	COG5002	protein histidine kinase activity
A9497_RS01780	COG0745	RESPONSE REGULATOR receiver
A9497_RS01785	COG1126	abc transporter atp-binding protein
A9497_RS01790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A9497_RS01795	COG0765	amino acid transport
A9497_RS01800	COG0765	amino acid transport
A9497_RS01825	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A9497_RS01835	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A9497_RS01840	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A9497_RS01840	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A9497_RS01850	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A9497_RS01855	COG1956	GAF domain-containing protein
A9497_RS01860	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A9497_RS01880	COG0335	large ribosomal subunit rRNA binding
A9497_RS01885	COG0038	chloride channel
A9497_RS01895	COG0038	chloride channel
A9497_RS01900	COG0716	FMN binding
A9497_RS01975	COG0469	pyruvate kinase activity
A9497_RS02025	COG0167	dihydroorotate dehydrogenase activity
A9497_RS02035	COG0776	regulation of translation
A9497_RS02045	COG2755	lipolytic protein G-D-S-L family
A9497_RS02050	COG1307	EDD domain protein, DegV family
A9497_RS02055	COG0497	DNA recombination
A9497_RS02060	COG1438	arginine binding
A9497_RS02065	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A9497_RS02090	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A9497_RS02110	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A9497_RS02110	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A9497_RS02115	COG0300	oxidoreductase activity
A9497_RS02130	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A9497_RS02140	COG0772	Belongs to the SEDS family
A9497_RS02155	COG0107	imidazoleglycerol-phosphate synthase activity
A9497_RS02165	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A9497_RS02175	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A9497_RS02230	COG0647	UMP catabolic process
A9497_RS02240	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A9497_RS02270	COG1088	dTDP-glucose 4,6-dehydratase activity
A9497_RS02280	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A9497_RS02285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A9497_RS02300	COG2384	SAM-dependent methyltransferase
A9497_RS02325	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A9497_RS02330	COG3442	glutamine amidotransferase
A9497_RS02335	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A9497_RS02335	COG0392	lysyltransferase activity
A9497_RS02350	COG0488	(ABC) transporter
A9497_RS02360	COG0513	Belongs to the DEAD box helicase family
A9497_RS02395	COG0372	Belongs to the citrate synthase family
A9497_RS02400	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A9497_RS02405	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A9497_RS02410	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A9497_RS02415	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A9497_RS02440	COG3764	Sortase (surface protein transpeptidase)
A9497_RS02460	COG0488	(ABC) transporter
A9497_RS02490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A9497_RS02495	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A9497_RS02495	COG1328	CTP reductase activity
A9497_RS02530	COG1196	nuclear chromosome segregation
A9497_RS02545	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A9497_RS02560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A9497_RS02570	COG1011	Hydrolase
A9497_RS02575	COG1760	l-serine dehydratase
A9497_RS02600	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A9497_RS02610	COG2197	response regulator
A9497_RS02615	COG4585	Histidine kinase
A9497_RS02625	COG1131	(ABC) transporter
A9497_RS02675	COG1131	(ABC) transporter
A9497_RS02695	COG0577	efflux transmembrane transporter activity
A9497_RS02700	COG1136	(ABC) transporter
A9497_RS02705	COG5002	protein histidine kinase activity
A9497_RS02705	COG2198	Histidine kinase
A9497_RS02705	COG0784	Response regulator, receiver
A9497_RS02710	COG0745	RESPONSE REGULATOR receiver
A9497_RS02720	COG2233	PERMEase
A9497_RS02725	COG2233	PERMEase
A9497_RS02730	COG0534	Mate efflux family protein
A9497_RS02735	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A9497_RS02735	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A9497_RS02745	COG1482	cell wall glycoprotein biosynthetic process
A9497_RS02750	COG1482	cell wall glycoprotein biosynthetic process
A9497_RS02760	COG0531	amino acid
A9497_RS02770	COG2514	catechol 2,3-dioxygenase activity
A9497_RS02775	COG1959	2 iron, 2 sulfur cluster binding
A9497_RS02785	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A9497_RS02790	COG0778	Nitroreductase
A9497_RS02800	COG0656	L-ascorbic acid biosynthetic process
A9497_RS02805	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A9497_RS02840	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A9497_RS02865	COG1280	lysine exporter protein (LysE YggA)
A9497_RS02875	COG1216	Glycosyl transferase, family 2
A9497_RS02875	COG1442	glycosyl transferase family 8
A9497_RS02880	COG0577	efflux transmembrane transporter activity
A9497_RS02925	COG1396	sequence-specific DNA binding
A9497_RS02930	COG2801	Transposase and inactivated derivatives
A9497_RS02945	COG0419	ATPase involved in DNA repair
A9497_RS02950	COG0420	3'-5' exonuclease activity
A9497_RS02955	COG3250	beta-galactosidase activity
A9497_RS02960	COG2211	Major facilitator Superfamily
A9497_RS02960	COG2190	(PTS) system
A9497_RS02965	COG2017	converts alpha-aldose to the beta-anomer
A9497_RS02970	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A9497_RS02985	COG1609	Transcriptional regulator
A9497_RS03000	COG3064	Membrane
A9497_RS03005	COG0488	(ABC) transporter
A9497_RS03060	COG2197	response regulator
A9497_RS03065	COG4585	Histidine kinase
A9497_RS03075	COG0515	serine threonine protein kinase
A9497_RS03075	COG2815	serine threonine protein kinase
A9497_RS03085	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A9497_RS03085	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A9497_RS03095	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A9497_RS03110	COG0552	protein localization to endoplasmic reticulum
A9497_RS03115	COG0561	phosphatase activity
A9497_RS03120	COG0561	phosphatase activity
A9497_RS03125	COG1725	Transcriptional regulator
A9497_RS03130	COG1131	(ABC) transporter
A9497_RS03140	COG4608	Belongs to the ABC transporter superfamily
A9497_RS03145	COG0444	Belongs to the ABC transporter superfamily
A9497_RS03150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A9497_RS03155	COG0601	transmembrane transport
A9497_RS03160	COG4166	transmembrane transport
A9497_RS03170	COG4166	transmembrane transport
A9497_RS03180	COG2801	Transposase and inactivated derivatives
A9497_RS03185	COG4608	Belongs to the ABC transporter superfamily
A9497_RS03190	COG0084	hydrolase, TatD family'
A9497_RS03195	COG2223	nitrite transmembrane transporter activity
A9497_RS03200	COG2801	Transposase and inactivated derivatives
A9497_RS03210	COG0280	phosphate acetyltransferase
A9497_RS03215	COG0564	pseudouridine synthase activity
A9497_RS03225	COG2357	RelA SpoT domain protein
A9497_RS03240	COG1104	cysteine desulfurase activity
A9497_RS03255	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A9497_RS03260	COG2003	Belongs to the UPF0758 family
A9497_RS03285	COG1215	transferase activity, transferring glycosyl groups
A9497_RS03300	COG1216	Glycosyl transferase, family 2
A9497_RS03300	COG1442	glycosyl transferase family 8
A9497_RS03320	COG1091	dTDP-4-dehydrorhamnose reductase activity
A9497_RS03330	COG0463	Glycosyl transferase, family 2
A9497_RS03335	COG2151	metal-sulfur cluster biosynthetic enzyme
A9497_RS03340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A9497_RS03345	COG0358	DNA primase activity
A9497_RS03350	COG1970	mechanosensitive ion channel activity
A9497_RS03360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A9497_RS03365	COG0436	Aminotransferase
A9497_RS03370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A9497_RS03375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A9497_RS03380	COG1051	belongs to the nudix hydrolase family
A9497_RS03405	COG0765	amino acid transport
A9497_RS03410	COG1126	abc transporter atp-binding protein
A9497_RS03430	COG1187	pseudouridine synthase activity
A9497_RS03475	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
A9497_RS03480	COG1518	maintenance of DNA repeat elements
A9497_RS03485	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
A9497_RS03490	COG0560	Phosphoserine phosphatase
A9497_RS03500	COG0187	DNA topoisomerase II activity
A9497_RS03510	COG1346	cytolysis
A9497_RS03515	COG1380	Effector of murein hydrolase LrgA
A9497_RS03525	COG1393	Belongs to the ArsC family
A9497_RS03535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A9497_RS03575	COG1177	transmembrane transport
A9497_RS03580	COG1176	ABC-type spermidine putrescine transport system, permease component I
A9497_RS03620	COG0531	amino acid
A9497_RS03625	COG0285	dihydrofolate synthase activity
A9497_RS03630	COG1837	Belongs to the UPF0109 family
A9497_RS03640	COG3615	Tellurite resistance protein tehB
A9497_RS03640	COG0500	methyltransferase
A9497_RS03645	COG0708	Exodeoxyribonuclease III
A9497_RS03660	COG1597	lipid kinase activity
A9497_RS03670	COG4708	membrane
A9497_RS03680	COG0024	Methionine aminopeptidase
A9497_RS03685	COG4109	DRTGG domain
A9497_RS03695	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A9497_RS03700	COG2333	competence protein COMEC
A9497_RS03700	COG0658	competence protein
A9497_RS03705	COG1596	polysaccharide export
A9497_RS03705	COG1555	photosystem II stabilization
A9497_RS03710	COG0204	Acyl-transferase
A9497_RS03715	COG0726	polysaccharide deacetylase
A9497_RS03720	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A9497_RS03730	COG0513	Belongs to the DEAD box helicase family
A9497_RS03750	COG1396	sequence-specific DNA binding
A9497_RS03755	COG2211	Major facilitator Superfamily
A9497_RS03770	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A9497_RS03785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A9497_RS03790	COG1126	abc transporter atp-binding protein
A9497_RS03795	COG0765	amino acid transport
A9497_RS03800	COG0765	amino acid transport
A9497_RS03815	COG2217	Heavy metal translocating P-type atpase
A9497_RS03825	COG0159	tryptophan synthase activity
A9497_RS03835	COG0135	phosphoribosylanthranilate isomerase activity
A9497_RS03850	COG0512	Glutamine amidotransferase of anthranilate synthase
A9497_RS03855	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A9497_RS03860	COG0287	Prephenate dehydrogenase
A9497_RS03860	COG1605	Chorismate mutase
A9497_RS03870	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A9497_RS03895	COG2176	DNA-directed DNA polymerase activity
A9497_RS03905	COG2151	metal-sulfur cluster biosynthetic enzyme
A9497_RS03915	COG2081	HI0933 family
A9497_RS03940	COG1131	(ABC) transporter
A9497_RS03945	COG0537	adenosine 5'-monophosphoramidase activity
A9497_RS03975	COG2226	methyltransferase
A9497_RS03980	COG0799	negative regulation of ribosome biogenesis
A9497_RS03985	COG1713	HD superfamily hydrolase involved in NAD metabolism
A9497_RS03990	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A9497_RS03995	COG1534	Rna-binding protein
A9497_RS04000	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A9497_RS04005	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A9497_RS04040	COG2723	6-phospho-beta-galactosidase activity
A9497_RS04055	COG1335	isochorismatase
A9497_RS04065	COG0436	Aminotransferase
A9497_RS04070	COG0589	response to stress
A9497_RS04085	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A9497_RS04090	COG1253	flavin adenine dinucleotide binding
A9497_RS04095	COG1119	ATPase activity
A9497_RS04100	COG0025	NhaP-type Na H and K H
A9497_RS04110	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A9497_RS04115	COG1242	4 iron, 4 sulfur cluster binding
A9497_RS04120	COG3480	Lon protease (S16) C-terminal proteolytic domain
A9497_RS04125	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A9497_RS04130	COG0742	ribosomal rna small subunit methyltransferase
A9497_RS04135	COG0492	ferredoxin-NADP+ reductase activity
A9497_RS04145	COG1126	abc transporter atp-binding protein
A9497_RS04155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A9497_RS04170	COG1882	Formate acetyltransferase
A9497_RS04200	COG0390	transport system, permease component
A9497_RS04205	COG4619	ABC transporter
A9497_RS04210	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A9497_RS04225	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A9497_RS04260	COG2801	Transposase and inactivated derivatives
A9497_RS04310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A9497_RS04320	COG1132	(ABC) transporter
A9497_RS04325	COG1132	(ABC) transporter
A9497_RS04340	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A9497_RS04345	COG4470	Protein conserved in bacteria
A9497_RS04350	COG0737	Belongs to the 5'-nucleotidase family
A9497_RS04355	COG0513	Belongs to the DEAD box helicase family
A9497_RS04365	COG0768	penicillin binding
A9497_RS04400	COG3152	Membrane
A9497_RS04410	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A9497_RS04425	COG4152	abc transporter atp-binding protein
A9497_RS04430	COG1811	Na channel or pump
A9497_RS04470	COG0561	phosphatase activity
A9497_RS04475	COG0252	asparaginase activity
A9497_RS04480	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A9497_RS04485	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A9497_RS04495	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A9497_RS04500	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A9497_RS04515	COG1482	cell wall glycoprotein biosynthetic process
A9497_RS04520	COG1940	carbohydrate kinase activity
A9497_RS04525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A9497_RS04525	COG2190	(PTS) system
A9497_RS04525	COG1263	PTS System
A9497_RS04530	COG1621	beta-fructofuranosidase activity
A9497_RS04535	COG1609	Transcriptional regulator
A9497_RS04555	COG2131	deaminase
A9497_RS04560	COG0006	proline dipeptidase activity
A9497_RS04575	COG1131	(ABC) transporter
A9497_RS04650	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A9497_RS04650	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A9497_RS04675	COG0681	Belongs to the peptidase S26 family
A9497_RS04680	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A9497_RS04690	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A9497_RS04700	COG0456	acetyltransferase
A9497_RS04705	COG1214	PFAM Peptidase M22, glycoprotease
A9497_RS04725	COG0174	glutamine synthetase
A9497_RS04730	COG0789	Transcriptional regulator
A9497_RS04765	COG2801	Transposase and inactivated derivatives
A9497_RS04800	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A9497_RS04845	COG0084	hydrolase, TatD family'
A9497_RS04850	COG1832	CoA-binding protein
A9497_RS04855	COG3118	belongs to the thioredoxin family
A9497_RS04920	COG0706	membrane insertase activity
A9497_RS04945	COG4166	transmembrane transport
A9497_RS04950	COG4166	transmembrane transport
A9497_RS04990	COG0756	dUTP diphosphatase activity
A9497_RS05025	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A9497_RS05030	COG0457	Tetratricopeptide repeat
A9497_RS05030	COG0705	Rhomboid family
A9497_RS05035	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A9497_RS05055	COG2226	methyltransferase
A9497_RS05085	COG0425	Belongs to the sulfur carrier protein TusA family
A9497_RS05090	COG2391	methyltransferase activity
A9497_RS05095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A9497_RS05100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A9497_RS05110	COG1363	Peptidase, m42
A9497_RS05115	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A9497_RS05120	COG1266	CAAX protease self-immunity
A9497_RS05180	COG1459	type II secretion system
A9497_RS05185	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A9497_RS05220	COG0440	acetolactate synthase activity
A9497_RS05225	COG0028	Belongs to the TPP enzyme family
A9497_RS05230	COG0129	dihydroxy-acid dehydratase activity
A9497_RS05235	COG1461	Dihydroxyacetone kinase
A9497_RS05245	COG0534	Mate efflux family protein
A9497_RS05270	COG1012	belongs to the aldehyde dehydrogenase family
A9497_RS05270	COG1454	alcohol dehydrogenase
A9497_RS05275	COG1454	alcohol dehydrogenase
A9497_RS05275	COG1012	belongs to the aldehyde dehydrogenase family
A9497_RS05280	COG1454	alcohol dehydrogenase
A9497_RS05280	COG1012	belongs to the aldehyde dehydrogenase family
A9497_RS05285	COG3590	peptidase
A9497_RS05290	COG0366	Alpha amylase catalytic
A9497_RS05295	COG0366	Alpha amylase catalytic
A9497_RS05300	COG0366	Alpha amylase catalytic
A9497_RS05310	COG1609	Transcriptional regulator
A9497_RS05315	COG2188	Transcriptional regulator
A9497_RS05320	COG4475	Protein of unknown function (DUF436)
A9497_RS05355	COG0640	Transcriptional regulator
A9497_RS05360	COG2217	Heavy metal translocating P-type atpase
A9497_RS05385	COG3328	transposase activity
A9497_RS05390	COG0582	viral genome integration into host DNA
A9497_RS05395	COG0191	fructose-bisphosphate aldolase activity
A9497_RS05455	COG0201	protein transport
A9497_RS05600	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A9497_RS05620	COG0515	serine threonine protein kinase
A9497_RS05625	COG1132	(ABC) transporter
A9497_RS05630	COG1396	sequence-specific DNA binding
A9497_RS05640	COG1132	(ABC) transporter
A9497_RS05680	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A9497_RS05720	COG0602	queuosine metabolic process
A9497_RS05730	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A9497_RS05755	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A9497_RS05765	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A9497_RS05790	COG2261	transglycosylase associated protein
A9497_RS05810	COG3237	CsbD-like
A9497_RS05820	COG3328	transposase activity
A9497_RS05840	COG1511	domain protein
A9497_RS05840	COG1511	domain protein
A9497_RS05850	COG3759	membrane
A9497_RS05865	COG0305	Participates in initiation and elongation during chromosome replication
A9497_RS05885	COG0494	nUDIX hydrolase
A9497_RS05900	COG0741	lytic transglycosylase activity
A9497_RS05905	COG1388	LysM domain
A9497_RS05905	COG3584	3D domain protein
A9497_RS05910	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A9497_RS05925	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A9497_RS05935	COG0612	Peptidase, M16
A9497_RS05965	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A9497_RS05970	COG0488	(ABC) transporter
A9497_RS06005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A9497_RS06010	COG1475	DNA binding
A9497_RS06020	COG0592	DNA-directed DNA polymerase activity
A9497_RS06030	COG0012	GTP binding
A9497_RS06040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A9497_RS06045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A9497_RS06075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A9497_RS06095	COG2801	Transposase and inactivated derivatives
A9497_RS06215	COG3942	CHAP domain
A9497_RS06230	COG0436	Aminotransferase
A9497_RS06245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A9497_RS06255	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A9497_RS06270	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A9497_RS06290	COG2801	Transposase and inactivated derivatives
A9497_RS06295	COG1388	LysM domain
A9497_RS06295	COG3942	CHAP domain
A9497_RS06300	COG0151	Belongs to the GarS family
A9497_RS06305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A9497_RS06325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A9497_RS06340	COG4550	Control of competence regulator ComK, YlbF/YmcA
A9497_RS06380	COG2818	Glycosylase
A9497_RS06395	COG1393	Belongs to the ArsC family
A9497_RS06485	COG2309	aminopeptidase activity
A9497_RS06505	COG2801	Transposase and inactivated derivatives
A9497_RS06525	COG1619	proteins homologs of microcin C7 resistance protein MccF
A9497_RS06550	COG4463	regulation of RNA biosynthetic process
A9497_RS06555	COG0542	response to heat
A9497_RS06565	COG1686	Belongs to the peptidase S11 family
A9497_RS06580	COG1045	serine acetyltransferase
A9497_RS06590	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
A9497_RS06605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A9497_RS06630	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A9497_RS06690	COG1705	Flagellar rod assembly protein muramidase FlgJ
A9497_RS06690	COG3942	CHAP domain
A9497_RS06705	COG3830	Belongs to the UPF0237 family
A9497_RS06720	COG1876	peptidase activity
A9497_RS06755	COG0351	phosphomethylpyrimidine kinase
A9497_RS06760	COG4720	Psort location CytoplasmicMembrane, score
A9497_RS06865	COG1473	amidohydrolase
A9497_RS06870	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A9497_RS06885	COG0668	transmembrane transport
A9497_RS06900	COG0504	CTP synthase activity
A9497_RS06910	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A9497_RS06920	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A9497_RS06925	COG0737	Belongs to the 5'-nucleotidase family
A9497_RS06960	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A9497_RS06990	COG1126	abc transporter atp-binding protein
A9497_RS06995	COG0765	amino acid transport
A9497_RS07010	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A9497_RS07020	COG0719	Fe-S assembly protein
A9497_RS07025	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A9497_RS07035	COG0719	Fe-S assembly protein
A9497_RS07040	COG4166	transmembrane transport
A9497_RS07045	COG0601	transmembrane transport
A9497_RS07060	COG0444	Belongs to the ABC transporter superfamily
A9497_RS07065	COG0444	Belongs to the ABC transporter superfamily
A9497_RS07070	COG0444	Belongs to the ABC transporter superfamily
A9497_RS07075	COG0444	Belongs to the ABC transporter superfamily
A9497_RS07095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A9497_RS07110	COG1121	(ABC) transporter
A9497_RS07115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A9497_RS07125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A9497_RS07125	COG1263	PTS System
A9497_RS07125	COG2190	(PTS) system
A9497_RS07130	COG1263	PTS System
A9497_RS07130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A9497_RS07130	COG2190	(PTS) system
A9497_RS07135	COG1263	PTS System
A9497_RS07135	COG2190	(PTS) system
A9497_RS07135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A9497_RS07165	COG4589	Belongs to the CDS family
A9497_RS07180	COG4120	Belongs to the binding-protein-dependent transport system permease family
A9497_RS07185	COG1116	anion transmembrane transporter activity
A9497_RS07185	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A9497_RS07225	COG0564	pseudouridine synthase activity
A9497_RS07230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A9497_RS07255	COG1349	DNA-binding transcription factor activity
A9497_RS07280	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A9497_RS07295	COG3579	cysteine-type endopeptidase activity
A9497_RS07300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A9497_RS07325	COG0116	Belongs to the methyltransferase superfamily
A9497_RS07335	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A9497_RS07355	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A9497_RS07385	COG1254	Belongs to the acylphosphatase family
A9497_RS07390	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A9497_RS07435	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A9497_RS07455	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A9497_RS07460	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A9497_RS07465	COG1187	pseudouridine synthase activity
A9497_RS07475	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A9497_RS07480	COG0569	domain protein
A9497_RS07490	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A9497_RS07495	COG0671	phosphoesterase, PA-phosphatase related
A9497_RS07515	COG2274	protein secretion by the type I secretion system
A9497_RS07520	COG2274	protein secretion by the type I secretion system
A9497_RS07525	COG2274	protein secretion by the type I secretion system
A9497_RS07575	COG0829	nickel cation binding
A9497_RS07580	COG0310	cobalt ion transport
A9497_RS07590	COG1122	ATPase activity
A9497_RS07595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A9497_RS07600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A9497_RS07620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A9497_RS07625	COG1464	Belongs to the NlpA lipoprotein family
A9497_RS07635	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A9497_RS07660	COG1122	ATPase activity
A9497_RS07670	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A9497_RS07680	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A9497_RS07695	COG0745	RESPONSE REGULATOR receiver
A9497_RS07700	COG5002	protein histidine kinase activity
A9497_RS07715	COG1484	DNA-dependent DNA replication
A9497_RS07730	COG2801	Transposase and inactivated derivatives
A9497_RS07760	COG3716	PTS system mannose fructose sorbose family IID component
A9497_RS07765	COG3715	PTS system
A9497_RS07775	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A9497_RS07780	COG0561	phosphatase activity
A9497_RS07785	COG2252	PERMEase
A9497_RS07790	COG0802	atpase or kinase
A9497_RS07795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A9497_RS07800	COG1316	TRANSCRIPTIONal
A9497_RS07810	COG0195	Participates in both transcription termination and antitermination
A9497_RS07815	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A9497_RS07835	COG1611	Belongs to the LOG family
A9497_RS07855	COG2244	polysaccharide biosynthetic process
A9497_RS07860	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A9497_RS07865	COG0626	cystathionine gamma-synthase activity
A9497_RS07870	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A9497_RS07900	COG4471	UPF0298 protein
A9497_RS07910	COG0559	Belongs to the binding-protein-dependent transport system permease family
A9497_RS07930	COG0517	IMP dehydrogenase activity
A9497_RS07945	COG1739	Uncharacterized protein family UPF0029
A9497_RS07950	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A9497_RS07955	COG1040	competence protein
A9497_RS08045	COG0527	aspartate kinase activity
A9497_RS08050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A9497_RS08055	COG1024	Enoyl-CoA hydratase
A9497_RS08060	COG1846	Transcriptional regulator
A9497_RS08080	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A9497_RS08085	COG1028	Short-chain dehydrogenase reductase Sdr
A9497_RS08090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A9497_RS08105	COG0439	Biotin carboxylase
A9497_RS08140	COG1349	DNA-binding transcription factor activity
A9497_RS08145	COG1105	Belongs to the carbohydrate kinase PfkB family
A9497_RS08155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A9497_RS08160	COG0285	dihydrofolate synthase activity
A9497_RS08170	COG1104	cysteine desulfurase activity
A9497_RS08235	COG0488	(ABC) transporter
A9497_RS08255	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A9497_RS08260	COG0242	peptide deformylase activity
A9497_RS08320	COG1702	phosphate starvation-inducible protein PhoH
A9497_RS08340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A9497_RS08340	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A9497_RS08365	COG4122	O-methyltransferase activity
A9497_RS08370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A9497_RS08400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A9497_RS08405	COG0436	Aminotransferase
A9497_RS08420	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A9497_RS08425	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A9497_RS08430	COG0726	polysaccharide deacetylase
A9497_RS08445	COG2962	Rard protein
A9497_RS08485	COG0356	it plays a direct role in the translocation of protons across the membrane
A9497_RS08520	COG0772	Belongs to the SEDS family
A9497_RS08540	COG0470	DNA polymerase III
A9497_RS08545	COG1774	PSP1 C-terminal conserved region
A9497_RS08550	COG4467	Involved in initiation control of chromosome replication
A9497_RS08560	COG0004	ammonium transporteR
A9497_RS08565	COG0347	Belongs to the P(II) protein family
A9497_RS08570	COG1705	Flagellar rod assembly protein muramidase FlgJ
A9497_RS08570	COG1388	LysM domain
A9497_RS08630	COG1113	amino acid transport
A9497_RS08640	COG2190	(PTS) system
A9497_RS08640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A9497_RS08640	COG1263	PTS System
A9497_RS08655	COG2801	Transposase and inactivated derivatives
A9497_RS08685	COG0583	DNA-binding transcription factor activity
A9497_RS08695	COG0564	pseudouridine synthase activity
A9497_RS08715	COG0505	Belongs to the CarA family
A9497_RS08750	COG0577	efflux transmembrane transporter activity
A9497_RS08755	COG0577	efflux transmembrane transporter activity
A9497_RS08785	COG0577	efflux transmembrane transporter activity
A9497_RS08790	COG2801	Transposase and inactivated derivatives
A9497_RS08855	COG3279	Response regulator of the LytR AlgR family
A9497_RS08865	COG1131	(ABC) transporter
A9497_RS08900	COG1187	pseudouridine synthase activity
A9497_RS08905	COG1473	amidohydrolase
A9497_RS08910	COG0686	Belongs to the AlaDH PNT family
A9497_RS08915	COG0686	Belongs to the AlaDH PNT family
A9497_RS08920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A9497_RS08985	COG0438	transferase activity, transferring glycosyl groups
A9497_RS09015	COG1272	protein, Hemolysin III
A9497_RS09030	COG3425	synthase
A9497_RS09040	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A9497_RS09055	COG0833	amino acid
A9497_RS09060	COG2040	homocysteine
A9497_RS09080	COG0187	DNA topoisomerase II activity
A9497_RS09090	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A9497_RS09110	COG0539	negative regulation of cytoplasmic translation
A9497_RS09140	COG0673	inositol 2-dehydrogenase activity
A9497_RS09155	COG0494	nUDIX hydrolase
A9497_RS09160	COG0542	response to heat
A9497_RS09165	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A9497_RS09170	COG4703	Protein of unknown function (DUF1797)
A9497_RS09175	COG0765	amino acid transport
A9497_RS09220	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A9497_RS09225	COG0768	penicillin binding
A9497_RS09230	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A9497_RS09240	COG3711	transcriptional antiterminator
A9497_RS09250	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A9497_RS09255	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A9497_RS09260	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A9497_RS09265	COG0237	dephospho-CoA kinase activity
A9497_RS09280	COG0557	exoribonuclease II activity
A9497_RS09295	COG1185	polyribonucleotide nucleotidyltransferase activity
A9497_RS09300	COG0006	proline dipeptidase activity
A9497_RS09305	COG1609	Transcriptional regulator
A9497_RS09335	COG1368	sulfuric ester hydrolase activity
A9497_RS09340	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A9497_RS09365	COG0287	Prephenate dehydrogenase
A9497_RS09390	COG0077	Prephenate dehydratase
A9497_RS09450	COG2963	transposase activity
A9497_RS09460	COG2801	Transposase and inactivated derivatives
A9497_RS09515	COG1518	maintenance of DNA repeat elements
A9497_RS09520	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
A9497_RS09530	COG3689	TIGRFAM TIGR03943 family protein
A9497_RS09535	COG0701	Predicted permease
A9497_RS09540	COG2183	response to ionizing radiation
A9497_RS09585	COG0826	peptidase U32
A9497_RS09595	COG1268	BioY protein
A9497_RS09605	COG4443	Transcriptional Coactivator p15 (PC4)
A9497_RS09615	COG1914	H( )-stimulated, divalent metal cation uptake system
A9497_RS09625	COG0494	nUDIX hydrolase
A9497_RS09635	COG3328	transposase activity
A9497_RS09645	COG1705	Flagellar rod assembly protein muramidase FlgJ
A9497_RS09645	COG1388	LysM domain
A9497_RS09660	COG0406	alpha-ribazole phosphatase activity
A9497_RS09665	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A9497_RS09700	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A9497_RS09750	COG1704	LemA family