locus-tag	class	description
AMD33_RS00010	COG1263	PTS System
AMD33_RS00010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AMD33_RS00010	COG2190	(PTS) system
AMD33_RS00020	COG2190	(PTS) system
AMD33_RS00020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AMD33_RS00020	COG1263	PTS System
AMD33_RS00050	COG4589	Belongs to the CDS family
AMD33_RS00065	COG4120	Belongs to the binding-protein-dependent transport system permease family
AMD33_RS00070	COG1116	anion transmembrane transporter activity
AMD33_RS00070	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AMD33_RS00110	COG2801	Transposase and inactivated derivatives
AMD33_RS00125	COG0564	pseudouridine synthase activity
AMD33_RS00130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AMD33_RS00185	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AMD33_RS00200	COG3579	cysteine-type endopeptidase activity
AMD33_RS00235	COG0116	Belongs to the methyltransferase superfamily
AMD33_RS00245	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AMD33_RS00265	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AMD33_RS00290	COG1254	Belongs to the acylphosphatase family
AMD33_RS00295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMD33_RS00340	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AMD33_RS00360	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AMD33_RS00365	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AMD33_RS00370	COG1187	pseudouridine synthase activity
AMD33_RS00380	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AMD33_RS00385	COG0569	domain protein
AMD33_RS00395	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AMD33_RS00400	COG0671	phosphoesterase, PA-phosphatase related
AMD33_RS00420	COG2274	protein secretion by the type I secretion system
AMD33_RS00425	COG2274	protein secretion by the type I secretion system
AMD33_RS00430	COG2274	protein secretion by the type I secretion system
AMD33_RS00480	COG0829	nickel cation binding
AMD33_RS00485	COG0310	cobalt ion transport
AMD33_RS00495	COG1122	ATPase activity
AMD33_RS00500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMD33_RS00525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMD33_RS00530	COG1464	Belongs to the NlpA lipoprotein family
AMD33_RS00565	COG1122	ATPase activity
AMD33_RS00575	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AMD33_RS00585	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AMD33_RS00600	COG0745	RESPONSE REGULATOR receiver
AMD33_RS00605	COG5002	protein histidine kinase activity
AMD33_RS00620	COG1484	DNA-dependent DNA replication
AMD33_RS00635	COG2801	Transposase and inactivated derivatives
AMD33_RS00660	COG3716	PTS system mannose fructose sorbose family IID component
AMD33_RS00665	COG3715	PTS system
AMD33_RS00675	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AMD33_RS00680	COG0561	phosphatase activity
AMD33_RS00685	COG2252	PERMEase
AMD33_RS00690	COG0802	atpase or kinase
AMD33_RS00695	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AMD33_RS00700	COG1316	TRANSCRIPTIONal
AMD33_RS00710	COG0195	Participates in both transcription termination and antitermination
AMD33_RS00715	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AMD33_RS00735	COG1611	Belongs to the LOG family
AMD33_RS00760	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AMD33_RS00765	COG0626	cystathionine gamma-synthase activity
AMD33_RS00770	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AMD33_RS00795	COG4471	UPF0298 protein
AMD33_RS00805	COG0559	Belongs to the binding-protein-dependent transport system permease family
AMD33_RS00825	COG0517	IMP dehydrogenase activity
AMD33_RS00840	COG1739	Uncharacterized protein family UPF0029
AMD33_RS00845	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AMD33_RS00850	COG1040	competence protein
AMD33_RS00945	COG0527	aspartate kinase activity
AMD33_RS00950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AMD33_RS00955	COG1024	Enoyl-CoA hydratase
AMD33_RS00960	COG1846	Transcriptional regulator
AMD33_RS00980	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AMD33_RS00985	COG1028	Short-chain dehydrogenase reductase Sdr
AMD33_RS00990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AMD33_RS01005	COG0439	Biotin carboxylase
AMD33_RS01060	COG2801	Transposase and inactivated derivatives
AMD33_RS01065	COG2963	transposase activity
AMD33_RS01080	COG1349	DNA-binding transcription factor activity
AMD33_RS01085	COG1105	Belongs to the carbohydrate kinase PfkB family
AMD33_RS01095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AMD33_RS01100	COG0285	dihydrofolate synthase activity
AMD33_RS01110	COG1104	cysteine desulfurase activity
AMD33_RS01175	COG0488	(ABC) transporter
AMD33_RS01195	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AMD33_RS01200	COG0242	peptide deformylase activity
AMD33_RS01260	COG1702	phosphate starvation-inducible protein PhoH
AMD33_RS01280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMD33_RS01280	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMD33_RS01305	COG4122	O-methyltransferase activity
AMD33_RS01310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AMD33_RS01335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AMD33_RS01340	COG0436	Aminotransferase
AMD33_RS01355	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AMD33_RS01360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AMD33_RS01365	COG0726	polysaccharide deacetylase
AMD33_RS01380	COG2962	Rard protein
AMD33_RS01420	COG0356	it plays a direct role in the translocation of protons across the membrane
AMD33_RS01455	COG0772	Belongs to the SEDS family
AMD33_RS01475	COG0470	DNA polymerase III
AMD33_RS01480	COG1774	PSP1 C-terminal conserved region
AMD33_RS01485	COG4467	Involved in initiation control of chromosome replication
AMD33_RS01495	COG0004	ammonium transporteR
AMD33_RS01500	COG0347	Belongs to the P(II) protein family
AMD33_RS01505	COG1388	LysM domain
AMD33_RS01505	COG1705	Flagellar rod assembly protein muramidase FlgJ
AMD33_RS01560	COG1113	amino acid transport
AMD33_RS01570	COG1263	PTS System
AMD33_RS01570	COG2190	(PTS) system
AMD33_RS01570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AMD33_RS01585	COG2801	Transposase and inactivated derivatives
AMD33_RS01615	COG0583	DNA-binding transcription factor activity
AMD33_RS01625	COG0564	pseudouridine synthase activity
AMD33_RS01645	COG0505	Belongs to the CarA family
AMD33_RS01680	COG3328	transposase activity
AMD33_RS01720	COG1131	(ABC) transporter
AMD33_RS01755	COG1187	pseudouridine synthase activity
AMD33_RS01760	COG1473	amidohydrolase
AMD33_RS01765	COG0686	Belongs to the AlaDH PNT family
AMD33_RS01770	COG0686	Belongs to the AlaDH PNT family
AMD33_RS01775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AMD33_RS01840	COG0438	transferase activity, transferring glycosyl groups
AMD33_RS01870	COG1272	protein, Hemolysin III
AMD33_RS01885	COG3425	synthase
AMD33_RS01895	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AMD33_RS01910	COG0833	amino acid
AMD33_RS01915	COG2040	homocysteine
AMD33_RS01935	COG0187	DNA topoisomerase II activity
AMD33_RS01945	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AMD33_RS01965	COG0539	negative regulation of cytoplasmic translation
AMD33_RS01995	COG0673	inositol 2-dehydrogenase activity
AMD33_RS02010	COG0494	nUDIX hydrolase
AMD33_RS02015	COG0542	response to heat
AMD33_RS02020	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AMD33_RS02025	COG4703	Protein of unknown function (DUF1797)
AMD33_RS02030	COG0765	amino acid transport
AMD33_RS02075	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AMD33_RS02080	COG0768	penicillin binding
AMD33_RS02085	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AMD33_RS02095	COG3711	transcriptional antiterminator
AMD33_RS02105	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AMD33_RS02110	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AMD33_RS02115	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AMD33_RS02120	COG0237	dephospho-CoA kinase activity
AMD33_RS02125	COG2814	Major facilitator Superfamily
AMD33_RS02135	COG0557	exoribonuclease II activity
AMD33_RS02150	COG1185	polyribonucleotide nucleotidyltransferase activity
AMD33_RS02155	COG0006	proline dipeptidase activity
AMD33_RS02160	COG1609	Transcriptional regulator
AMD33_RS02195	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AMD33_RS02220	COG0287	Prephenate dehydrogenase
AMD33_RS02245	COG0077	Prephenate dehydratase
AMD33_RS02305	COG1518	maintenance of DNA repeat elements
AMD33_RS02310	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AMD33_RS02320	COG3689	TIGRFAM TIGR03943 family protein
AMD33_RS02325	COG0701	Predicted permease
AMD33_RS02330	COG2183	response to ionizing radiation
AMD33_RS02375	COG0826	peptidase U32
AMD33_RS02385	COG1268	BioY protein
AMD33_RS02395	COG4443	Transcriptional Coactivator p15 (PC4)
AMD33_RS02400	COG1914	H( )-stimulated, divalent metal cation uptake system
AMD33_RS02435	COG1388	LysM domain
AMD33_RS02435	COG1705	Flagellar rod assembly protein muramidase FlgJ
AMD33_RS02450	COG0406	alpha-ribazole phosphatase activity
AMD33_RS02455	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AMD33_RS02490	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AMD33_RS02510	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
AMD33_RS02515	COG3620	sequence-specific DNA binding
AMD33_RS02535	COG1704	LemA family
AMD33_RS02540	COG0501	Belongs to the peptidase M48B family
AMD33_RS02555	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AMD33_RS02565	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AMD33_RS02580	COG0783	Belongs to the Dps family
AMD33_RS02585	COG0735	belongs to the Fur family
AMD33_RS02590	COG4483	Protein conserved in bacteria
AMD33_RS02595	COG1940	carbohydrate kinase activity
AMD33_RS02600	COG1217	gtp-binding protein TYPA
AMD33_RS02655	COG3599	regulation of cell shape
AMD33_RS02690	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AMD33_RS02695	COG0625	glutathione transferase activity
AMD33_RS02700	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AMD33_RS02715	COG2890	protein-(glutamine-N5) methyltransferase activity
AMD33_RS02745	COG1132	(ABC) transporter
AMD33_RS02760	COG1696	Membrane protein involved in D-alanine export
AMD33_RS02770	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AMD33_RS02780	COG2801	Transposase and inactivated derivatives
AMD33_RS02800	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AMD33_RS02805	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AMD33_RS02870	COG1396	sequence-specific DNA binding
AMD33_RS02875	COG0582	viral genome integration into host DNA
AMD33_RS02935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AMD33_RS02960	COG0765	amino acid transport
AMD33_RS02965	COG0765	amino acid transport
AMD33_RS02970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMD33_RS02975	COG1126	abc transporter atp-binding protein
AMD33_RS02980	COG0745	RESPONSE REGULATOR receiver
AMD33_RS02985	COG5002	protein histidine kinase activity
AMD33_RS02990	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AMD33_RS03035	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AMD33_RS03040	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AMD33_RS03045	COG2884	Cell division ATP-binding protein ftsE
AMD33_RS03050	COG2177	Part of the ABC transporter FtsEX involved in
AMD33_RS03055	COG1051	belongs to the nudix hydrolase family
AMD33_RS03060	COG0628	permease
AMD33_RS03070	COG0681	Belongs to the peptidase S26 family
AMD33_RS03135	COG1573	uracil-dna glycosylase
AMD33_RS03155	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AMD33_RS03180	COG1316	TRANSCRIPTIONal
AMD33_RS03220	COG0562	UDP-galactopyranose mutase
AMD33_RS03230	COG1216	Glycosyl transferase, family 2
AMD33_RS03230	COG1442	glycosyl transferase family 8
AMD33_RS03245	COG1091	dTDP-4-dehydrorhamnose reductase activity
AMD33_RS03290	COG1316	TRANSCRIPTIONal
AMD33_RS03295	COG2801	Transposase and inactivated derivatives
AMD33_RS03300	COG2963	transposase activity
AMD33_RS03325	COG2244	polysaccharide biosynthetic process
AMD33_RS03335	COG1216	Glycosyl transferase, family 2
AMD33_RS03335	COG1442	glycosyl transferase family 8
AMD33_RS03340	COG2801	Transposase and inactivated derivatives
AMD33_RS03350	COG2963	transposase activity
AMD33_RS03355	COG0438	transferase activity, transferring glycosyl groups
AMD33_RS03370	COG0628	permease
AMD33_RS03385	COG2723	6-phospho-beta-galactosidase activity
AMD33_RS03415	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AMD33_RS03450	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AMD33_RS03455	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMD33_RS03455	COG0022	dehydrogenase e1 component
AMD33_RS03460	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMD33_RS03495	COG1523	belongs to the glycosyl hydrolase 13 family
AMD33_RS03505	COG1523	belongs to the glycosyl hydrolase 13 family
AMD33_RS03515	COG2822	iron ion transport
AMD33_RS03520	COG2837	iron assimilation
AMD33_RS03525	COG0672	)-iron permease
AMD33_RS03530	COG0805	protein transport
AMD33_RS03535	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AMD33_RS03550	COG1640	4-alpha-glucanotransferase
AMD33_RS03555	COG0058	SHG alpha-glucan phosphorylase activity
AMD33_RS03570	COG0095	Lipoate-protein ligase
AMD33_RS03585	COG0704	Plays a role in the regulation of phosphate uptake
AMD33_RS03600	COG0581	inorganic phosphate transmembrane transporter activity
AMD33_RS03605	COG0573	inorganic phosphate transmembrane transporter activity
AMD33_RS03615	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AMD33_RS03615	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AMD33_RS03620	COG0483	inositol monophosphate 1-phosphatase activity
AMD33_RS03630	COG1393	Belongs to the ArsC family
AMD33_RS03635	COG0196	riboflavin kinase activity
AMD33_RS03640	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AMD33_RS03670	COG2873	o-acetylhomoserine
AMD33_RS03680	COG1115	amino acid carrier protein
AMD33_RS03710	COG0737	Belongs to the 5'-nucleotidase family
AMD33_RS03720	COG0765	amino acid transport
AMD33_RS03725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMD33_RS03730	COG0154	amidase activity
AMD33_RS03735	COG3104	oligopeptide transport
AMD33_RS03750	COG0284	orotidine-5'-phosphate decarboxylase activity
AMD33_RS03765	COG1567	CRISPR-associated RAMP protein, Csm4 family
AMD33_RS03770	COG1337	RAMP superfamily
AMD33_RS03790	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AMD33_RS03800	COG0167	dihydroorotate dehydrogenase activity
AMD33_RS03810	COG0047	phosphoribosylformylglycinamidine synthase activity
AMD33_RS03840	COG1293	RNA-binding protein homologous to eukaryotic snRNP
AMD33_RS03860	COG4607	ABC-type enterochelin transport system periplasmic component
AMD33_RS03865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AMD33_RS03890	COG1063	alcohol dehydrogenase
AMD33_RS03900	COG1230	cation diffusion facilitator family transporter
AMD33_RS03930	COG3527	Alpha-acetolactate decarboxylase
AMD33_RS03935	COG0028	Belongs to the TPP enzyme family
AMD33_RS03945	COG0010	Belongs to the arginase family
AMD33_RS03950	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AMD33_RS03960	COG1396	sequence-specific DNA binding
AMD33_RS03965	COG0481	GTPase activity
AMD33_RS03990	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AMD33_RS04010	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AMD33_RS04015	COG0758	DNA mediated transformation
AMD33_RS04020	COG1940	carbohydrate kinase activity
AMD33_RS04030	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AMD33_RS04040	COG1827	regulation of RNA biosynthetic process
AMD33_RS04050	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AMD33_RS04060	COG2188	Transcriptional regulator
AMD33_RS04065	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AMD33_RS04065	COG0519	Catalyzes the synthesis of GMP from XMP
AMD33_RS04070	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AMD33_RS04075	COG1064	alcohol dehydrogenase
AMD33_RS04090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMD33_RS04095	COG1126	abc transporter atp-binding protein
AMD33_RS04100	COG0765	amino acid transport
AMD33_RS04105	COG2824	Alkylphosphonate utilization operon protein PhnA
AMD33_RS04110	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AMD33_RS04125	COG1705	Flagellar rod assembly protein muramidase FlgJ
AMD33_RS04125	COG3942	CHAP domain
AMD33_RS04140	COG3443	Belongs to the bacterial solute-binding protein 9 family
AMD33_RS04140	COG0803	Belongs to the bacterial solute-binding protein 9 family
AMD33_RS04165	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AMD33_RS04185	COG1045	serine acetyltransferase
AMD33_RS04190	COG0626	cystathionine gamma-synthase activity
AMD33_RS04195	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AMD33_RS04210	COG2217	Heavy metal translocating P-type atpase
AMD33_RS04225	COG1278	Cold shock
AMD33_RS04270	COG0720	synthase
AMD33_RS04280	COG0251	oxidation-reduction process
AMD33_RS04310	COG0017	Asparaginyl-tRNA synthetase
AMD33_RS04315	COG0436	Aminotransferase
AMD33_RS04325	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AMD33_RS04325	COG1199	ATP-dependent helicase activity
AMD33_RS04335	COG1079	Belongs to the binding-protein-dependent transport system permease family
AMD33_RS04340	COG4603	Belongs to the binding-protein-dependent transport system permease family
AMD33_RS04345	COG3845	ABC transporter
AMD33_RS04350	COG1744	ABC transporter substrate-binding protein PnrA-like
AMD33_RS04355	COG0295	cytidine deaminase activity
AMD33_RS04365	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AMD33_RS04375	COG2813	Specifically methylates the guanine in position
AMD33_RS04390	COG2801	Transposase and inactivated derivatives
AMD33_RS04415	COG0038	chloride channel
AMD33_RS04435	COG2801	Transposase and inactivated derivatives
AMD33_RS04445	COG5002	protein histidine kinase activity
AMD33_RS04450	COG5002	protein histidine kinase activity
AMD33_RS04475	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AMD33_RS04480	COG4684	Psort location CytoplasmicMembrane, score
AMD33_RS04485	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMD33_RS04505	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AMD33_RS04510	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AMD33_RS04510	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AMD33_RS04520	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AMD33_RS04525	COG1956	GAF domain-containing protein
AMD33_RS04530	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AMD33_RS04540	COG0335	large ribosomal subunit rRNA binding
AMD33_RS04545	COG0038	chloride channel
AMD33_RS04555	COG0038	chloride channel
AMD33_RS04560	COG0716	FMN binding
AMD33_RS04625	COG3328	transposase activity
AMD33_RS04640	COG0469	pyruvate kinase activity
AMD33_RS04690	COG0167	dihydroorotate dehydrogenase activity
AMD33_RS04700	COG0776	regulation of translation
AMD33_RS04710	COG2755	lipolytic protein G-D-S-L family
AMD33_RS04715	COG1307	EDD domain protein, DegV family
AMD33_RS04720	COG0497	DNA recombination
AMD33_RS04725	COG1438	arginine binding
AMD33_RS04730	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AMD33_RS04755	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AMD33_RS04775	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AMD33_RS04775	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AMD33_RS04780	COG0300	oxidoreductase activity
AMD33_RS04795	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AMD33_RS04800	COG0772	Belongs to the SEDS family
AMD33_RS04815	COG0107	imidazoleglycerol-phosphate synthase activity
AMD33_RS04825	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AMD33_RS04835	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AMD33_RS04860	COG2801	Transposase and inactivated derivatives
AMD33_RS04865	COG2801	Transposase and inactivated derivatives
AMD33_RS04900	COG0647	UMP catabolic process
AMD33_RS04910	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AMD33_RS04935	COG1088	dTDP-glucose 4,6-dehydratase activity
AMD33_RS04945	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AMD33_RS04950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMD33_RS04965	COG2384	SAM-dependent methyltransferase
AMD33_RS04990	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AMD33_RS04995	COG3442	glutamine amidotransferase
AMD33_RS05000	COG0392	lysyltransferase activity
AMD33_RS05000	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AMD33_RS05025	COG0513	Belongs to the DEAD box helicase family
AMD33_RS05060	COG0372	Belongs to the citrate synthase family
AMD33_RS05065	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AMD33_RS05070	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AMD33_RS05075	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMD33_RS05080	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMD33_RS05110	COG3764	Sortase (surface protein transpeptidase)
AMD33_RS05130	COG0488	(ABC) transporter
AMD33_RS05160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMD33_RS05165	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AMD33_RS05165	COG1328	CTP reductase activity
AMD33_RS05200	COG1196	nuclear chromosome segregation
AMD33_RS05215	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AMD33_RS05235	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMD33_RS05245	COG1011	Hydrolase
AMD33_RS05255	COG0517	IMP dehydrogenase activity
AMD33_RS05255	COG1125	glycine betaine transport
AMD33_RS05270	COG2986	histidine ammonia-lyase
AMD33_RS05280	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AMD33_RS05285	COG1760	l-serine dehydratase
AMD33_RS05315	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AMD33_RS05325	COG2197	response regulator
AMD33_RS05330	COG4585	Histidine kinase
AMD33_RS05340	COG1131	(ABC) transporter
AMD33_RS05355	COG0385	Bile acid
AMD33_RS05370	COG1131	(ABC) transporter
AMD33_RS05390	COG0577	efflux transmembrane transporter activity
AMD33_RS05400	COG2198	Histidine kinase
AMD33_RS05400	COG0784	Response regulator, receiver
AMD33_RS05400	COG5002	protein histidine kinase activity
AMD33_RS05405	COG0745	RESPONSE REGULATOR receiver
AMD33_RS05415	COG2233	PERMEase
AMD33_RS05420	COG2233	PERMEase
AMD33_RS05425	COG0534	Mate efflux family protein
AMD33_RS05430	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AMD33_RS05430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AMD33_RS05440	COG1482	cell wall glycoprotein biosynthetic process
AMD33_RS05445	COG1482	cell wall glycoprotein biosynthetic process
AMD33_RS05455	COG0531	amino acid
AMD33_RS05465	COG2514	catechol 2,3-dioxygenase activity
AMD33_RS05470	COG1959	2 iron, 2 sulfur cluster binding
AMD33_RS05480	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AMD33_RS05485	COG0778	Nitroreductase
AMD33_RS05495	COG0656	L-ascorbic acid biosynthetic process
AMD33_RS05500	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AMD33_RS05515	COG0745	RESPONSE REGULATOR receiver
AMD33_RS05540	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AMD33_RS05560	COG1280	lysine exporter protein (LysE YggA)
AMD33_RS05570	COG1216	Glycosyl transferase, family 2
AMD33_RS05570	COG1442	glycosyl transferase family 8
AMD33_RS05575	COG0577	efflux transmembrane transporter activity
AMD33_RS05620	COG1396	sequence-specific DNA binding
AMD33_RS05625	COG2801	Transposase and inactivated derivatives
AMD33_RS05640	COG0419	ATPase involved in DNA repair
AMD33_RS05645	COG0420	3'-5' exonuclease activity
AMD33_RS05650	COG3250	beta-galactosidase activity
AMD33_RS05655	COG2190	(PTS) system
AMD33_RS05655	COG2211	Major facilitator Superfamily
AMD33_RS05660	COG2017	converts alpha-aldose to the beta-anomer
AMD33_RS05665	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AMD33_RS05680	COG1609	Transcriptional regulator
AMD33_RS05695	COG3064	Membrane
AMD33_RS05700	COG0488	(ABC) transporter
AMD33_RS05755	COG2197	response regulator
AMD33_RS05760	COG4585	Histidine kinase
AMD33_RS05770	COG0515	serine threonine protein kinase
AMD33_RS05770	COG2815	serine threonine protein kinase
AMD33_RS05780	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AMD33_RS05780	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AMD33_RS05790	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AMD33_RS05805	COG0552	protein localization to endoplasmic reticulum
AMD33_RS05810	COG0561	phosphatase activity
AMD33_RS05815	COG0561	phosphatase activity
AMD33_RS05820	COG1725	Transcriptional regulator
AMD33_RS05825	COG1131	(ABC) transporter
AMD33_RS05840	COG0444	Belongs to the ABC transporter superfamily
AMD33_RS05845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMD33_RS05850	COG0601	transmembrane transport
AMD33_RS05865	COG4166	transmembrane transport
AMD33_RS05875	COG2801	Transposase and inactivated derivatives
AMD33_RS05880	COG0084	hydrolase, TatD family'
AMD33_RS05885	COG2223	nitrite transmembrane transporter activity
AMD33_RS05890	COG2801	Transposase and inactivated derivatives
AMD33_RS05900	COG0280	phosphate acetyltransferase
AMD33_RS05905	COG0564	pseudouridine synthase activity
AMD33_RS05915	COG2357	RelA SpoT domain protein
AMD33_RS05930	COG1104	cysteine desulfurase activity
AMD33_RS05945	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AMD33_RS05950	COG2003	Belongs to the UPF0758 family
AMD33_RS05975	COG1215	transferase activity, transferring glycosyl groups
AMD33_RS05985	COG1442	glycosyl transferase family 8
AMD33_RS05985	COG1216	Glycosyl transferase, family 2
AMD33_RS06005	COG1091	dTDP-4-dehydrorhamnose reductase activity
AMD33_RS06015	COG0463	Glycosyl transferase, family 2
AMD33_RS06025	COG2151	metal-sulfur cluster biosynthetic enzyme
AMD33_RS06030	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AMD33_RS06035	COG0358	DNA primase activity
AMD33_RS06040	COG1970	mechanosensitive ion channel activity
AMD33_RS06050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMD33_RS06060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMD33_RS06065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMD33_RS06070	COG1051	belongs to the nudix hydrolase family
AMD33_RS06095	COG0765	amino acid transport
AMD33_RS06100	COG1126	abc transporter atp-binding protein
AMD33_RS06115	COG1187	pseudouridine synthase activity
AMD33_RS06160	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AMD33_RS06165	COG1518	maintenance of DNA repeat elements
AMD33_RS06175	COG0560	Phosphoserine phosphatase
AMD33_RS06185	COG0187	DNA topoisomerase II activity
AMD33_RS06195	COG1346	cytolysis
AMD33_RS06200	COG1380	Effector of murein hydrolase LrgA
AMD33_RS06210	COG1393	Belongs to the ArsC family
AMD33_RS06220	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AMD33_RS06235	COG1940	carbohydrate kinase activity
AMD33_RS06260	COG1177	transmembrane transport
AMD33_RS06265	COG1176	ABC-type spermidine putrescine transport system, permease component I
AMD33_RS06305	COG0531	amino acid
AMD33_RS06310	COG0285	dihydrofolate synthase activity
AMD33_RS06315	COG1837	Belongs to the UPF0109 family
AMD33_RS06325	COG0500	methyltransferase
AMD33_RS06325	COG3615	Tellurite resistance protein tehB
AMD33_RS06335	COG0708	Exodeoxyribonuclease III
AMD33_RS06350	COG1597	lipid kinase activity
AMD33_RS06360	COG4708	membrane
AMD33_RS06370	COG0024	Methionine aminopeptidase
AMD33_RS06375	COG4109	DRTGG domain
AMD33_RS06385	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AMD33_RS06390	COG0658	competence protein
AMD33_RS06390	COG2333	competence protein COMEC
AMD33_RS06395	COG1555	photosystem II stabilization
AMD33_RS06395	COG1596	polysaccharide export
AMD33_RS06400	COG0204	Acyl-transferase
AMD33_RS06410	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AMD33_RS06420	COG0513	Belongs to the DEAD box helicase family
AMD33_RS06440	COG1396	sequence-specific DNA binding
AMD33_RS06445	COG2211	Major facilitator Superfamily
AMD33_RS06460	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AMD33_RS06475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMD33_RS06480	COG1126	abc transporter atp-binding protein
AMD33_RS06485	COG0765	amino acid transport
AMD33_RS06490	COG0765	amino acid transport
AMD33_RS06505	COG2217	Heavy metal translocating P-type atpase
AMD33_RS06515	COG0159	tryptophan synthase activity
AMD33_RS06525	COG0135	phosphoribosylanthranilate isomerase activity
AMD33_RS06540	COG0512	Glutamine amidotransferase of anthranilate synthase
AMD33_RS06545	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AMD33_RS06550	COG0287	Prephenate dehydrogenase
AMD33_RS06550	COG1605	Chorismate mutase
AMD33_RS06560	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AMD33_RS06585	COG2176	DNA-directed DNA polymerase activity
AMD33_RS06595	COG2151	metal-sulfur cluster biosynthetic enzyme
AMD33_RS06605	COG2081	HI0933 family
AMD33_RS06630	COG1131	(ABC) transporter
AMD33_RS06635	COG0537	adenosine 5'-monophosphoramidase activity
AMD33_RS06665	COG2226	methyltransferase
AMD33_RS06670	COG0799	negative regulation of ribosome biogenesis
AMD33_RS06675	COG1713	HD superfamily hydrolase involved in NAD metabolism
AMD33_RS06680	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AMD33_RS06685	COG1534	Rna-binding protein
AMD33_RS06690	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AMD33_RS06695	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AMD33_RS06745	COG1335	isochorismatase
AMD33_RS06755	COG0436	Aminotransferase
AMD33_RS06760	COG0589	response to stress
AMD33_RS06775	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AMD33_RS06780	COG1253	flavin adenine dinucleotide binding
AMD33_RS06785	COG1119	ATPase activity
AMD33_RS06790	COG0025	NhaP-type Na H and K H
AMD33_RS06800	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AMD33_RS06805	COG1242	4 iron, 4 sulfur cluster binding
AMD33_RS06810	COG3480	Lon protease (S16) C-terminal proteolytic domain
AMD33_RS06815	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AMD33_RS06820	COG0742	ribosomal rna small subunit methyltransferase
AMD33_RS06825	COG0492	ferredoxin-NADP+ reductase activity
AMD33_RS06835	COG1126	abc transporter atp-binding protein
AMD33_RS06860	COG1882	Formate acetyltransferase
AMD33_RS06890	COG0390	transport system, permease component
AMD33_RS06895	COG4619	ABC transporter
AMD33_RS06900	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AMD33_RS06915	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AMD33_RS06950	COG2801	Transposase and inactivated derivatives
AMD33_RS06995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD33_RS07000	COG2274	protein secretion by the type I secretion system
AMD33_RS07005	COG1132	(ABC) transporter
AMD33_RS07010	COG1132	(ABC) transporter
AMD33_RS07030	COG4470	Protein conserved in bacteria
AMD33_RS07035	COG0737	Belongs to the 5'-nucleotidase family
AMD33_RS07040	COG0513	Belongs to the DEAD box helicase family
AMD33_RS07050	COG0768	penicillin binding
AMD33_RS07085	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AMD33_RS07100	COG4152	abc transporter atp-binding protein
AMD33_RS07105	COG1811	Na channel or pump
AMD33_RS07110	COG1074	ATP-dependent DNA helicase activity
AMD33_RS07145	COG0561	phosphatase activity
AMD33_RS07150	COG0252	asparaginase activity
AMD33_RS07155	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AMD33_RS07160	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AMD33_RS07170	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AMD33_RS07175	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AMD33_RS07190	COG1482	cell wall glycoprotein biosynthetic process
AMD33_RS07195	COG1940	carbohydrate kinase activity
AMD33_RS07200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AMD33_RS07200	COG1263	PTS System
AMD33_RS07200	COG2190	(PTS) system
AMD33_RS07205	COG1621	beta-fructofuranosidase activity
AMD33_RS07210	COG1609	Transcriptional regulator
AMD33_RS07230	COG2131	deaminase
AMD33_RS07235	COG0006	proline dipeptidase activity
AMD33_RS07250	COG1131	(ABC) transporter
AMD33_RS07325	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AMD33_RS07325	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AMD33_RS07350	COG0681	Belongs to the peptidase S26 family
AMD33_RS07355	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AMD33_RS07375	COG0456	acetyltransferase
AMD33_RS07380	COG1214	PFAM Peptidase M22, glycoprotease
AMD33_RS07400	COG0174	glutamine synthetase
AMD33_RS07405	COG0789	Transcriptional regulator
AMD33_RS07445	COG2801	Transposase and inactivated derivatives
AMD33_RS07450	COG2801	Transposase and inactivated derivatives
AMD33_RS07480	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AMD33_RS07525	COG0084	hydrolase, TatD family'
AMD33_RS07530	COG1832	CoA-binding protein
AMD33_RS07535	COG3118	belongs to the thioredoxin family
AMD33_RS07595	COG0706	membrane insertase activity
AMD33_RS07620	COG4166	transmembrane transport
AMD33_RS07625	COG4166	transmembrane transport
AMD33_RS07665	COG0756	dUTP diphosphatase activity
AMD33_RS07700	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AMD33_RS07705	COG0705	Rhomboid family
AMD33_RS07705	COG0457	Tetratricopeptide repeat
AMD33_RS07710	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AMD33_RS07730	COG2226	methyltransferase
AMD33_RS07760	COG0425	Belongs to the sulfur carrier protein TusA family
AMD33_RS07765	COG2391	methyltransferase activity
AMD33_RS07770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMD33_RS07775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AMD33_RS07785	COG1363	Peptidase, m42
AMD33_RS07790	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AMD33_RS07795	COG1266	CAAX protease self-immunity
AMD33_RS07850	COG1459	type II secretion system
AMD33_RS07855	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AMD33_RS07895	COG0440	acetolactate synthase activity
AMD33_RS07900	COG0028	Belongs to the TPP enzyme family
AMD33_RS07905	COG0129	dihydroxy-acid dehydratase activity
AMD33_RS07920	COG0534	Mate efflux family protein
AMD33_RS07940	COG1454	alcohol dehydrogenase
AMD33_RS07940	COG1012	belongs to the aldehyde dehydrogenase family
AMD33_RS07945	COG1454	alcohol dehydrogenase
AMD33_RS07945	COG1012	belongs to the aldehyde dehydrogenase family
AMD33_RS07950	COG1454	alcohol dehydrogenase
AMD33_RS07950	COG1012	belongs to the aldehyde dehydrogenase family
AMD33_RS07955	COG3590	peptidase
AMD33_RS07960	COG0366	Alpha amylase catalytic
AMD33_RS07965	COG0366	Alpha amylase catalytic
AMD33_RS07970	COG0366	Alpha amylase catalytic
AMD33_RS07980	COG1609	Transcriptional regulator
AMD33_RS07985	COG2188	Transcriptional regulator
AMD33_RS07990	COG4475	Protein of unknown function (DUF436)
AMD33_RS08020	COG1301	dicarboxylic acid transport
AMD33_RS08090	COG0191	fructose-bisphosphate aldolase activity
AMD33_RS08150	COG0201	protein transport
AMD33_RS08295	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AMD33_RS08310	COG0515	serine threonine protein kinase
AMD33_RS08315	COG1132	(ABC) transporter
AMD33_RS08320	COG1396	sequence-specific DNA binding
AMD33_RS08330	COG1132	(ABC) transporter
AMD33_RS08355	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AMD33_RS08385	COG1328	CTP reductase activity
AMD33_RS08395	COG0602	queuosine metabolic process
AMD33_RS08425	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AMD33_RS08430	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AMD33_RS08440	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AMD33_RS08465	COG2261	transglycosylase associated protein
AMD33_RS08480	COG3237	CsbD-like
AMD33_RS08500	COG1511	domain protein
AMD33_RS08500	COG1511	domain protein
AMD33_RS08510	COG3759	membrane
AMD33_RS08525	COG0305	Participates in initiation and elongation during chromosome replication
AMD33_RS08545	COG0494	nUDIX hydrolase
AMD33_RS08560	COG0741	lytic transglycosylase activity
AMD33_RS08565	COG3584	3D domain protein
AMD33_RS08565	COG1388	LysM domain
AMD33_RS08570	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AMD33_RS08585	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AMD33_RS08625	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AMD33_RS08630	COG0488	(ABC) transporter
AMD33_RS08665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMD33_RS08670	COG1475	DNA binding
AMD33_RS08680	COG0592	DNA-directed DNA polymerase activity
AMD33_RS08690	COG0012	GTP binding
AMD33_RS08700	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AMD33_RS08705	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AMD33_RS08735	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMD33_RS08885	COG3942	CHAP domain
AMD33_RS08900	COG0436	Aminotransferase
AMD33_RS08915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AMD33_RS08925	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AMD33_RS08940	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AMD33_RS08960	COG2801	Transposase and inactivated derivatives
AMD33_RS08965	COG3942	CHAP domain
AMD33_RS08965	COG1388	LysM domain
AMD33_RS08970	COG0151	Belongs to the GarS family
AMD33_RS08975	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AMD33_RS08995	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AMD33_RS09010	COG4550	Control of competence regulator ComK, YlbF/YmcA
AMD33_RS09050	COG2818	Glycosylase
AMD33_RS09060	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AMD33_RS09065	COG1393	Belongs to the ArsC family
AMD33_RS09155	COG2309	aminopeptidase activity
AMD33_RS09170	COG0431	NADPH-dependent FMN reductase
AMD33_RS09210	COG4463	regulation of RNA biosynthetic process
AMD33_RS09215	COG0542	response to heat
AMD33_RS09225	COG1686	Belongs to the peptidase S11 family
AMD33_RS09240	COG1045	serine acetyltransferase
AMD33_RS09250	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AMD33_RS09265	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMD33_RS09290	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AMD33_RS09350	COG1705	Flagellar rod assembly protein muramidase FlgJ
AMD33_RS09350	COG3942	CHAP domain
AMD33_RS09365	COG3830	Belongs to the UPF0237 family
AMD33_RS09375	COG0588	phosphoglycerate mutase activity
AMD33_RS09380	COG1876	peptidase activity
AMD33_RS09415	COG0351	phosphomethylpyrimidine kinase
AMD33_RS09515	COG4166	transmembrane transport
AMD33_RS09530	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AMD33_RS09545	COG0668	transmembrane transport
AMD33_RS09560	COG0504	CTP synthase activity
AMD33_RS09570	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AMD33_RS09580	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AMD33_RS09585	COG0737	Belongs to the 5'-nucleotidase family
AMD33_RS09595	COG0737	Belongs to the 5'-nucleotidase family
AMD33_RS09600	COG0737	Belongs to the 5'-nucleotidase family
AMD33_RS09640	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AMD33_RS09670	COG1126	abc transporter atp-binding protein
AMD33_RS09675	COG0765	amino acid transport
AMD33_RS09680	COG1968	undecaprenyl-diphosphatase activity
AMD33_RS09690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AMD33_RS09700	COG0719	Fe-S assembly protein
AMD33_RS09705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AMD33_RS09715	COG0719	Fe-S assembly protein
AMD33_RS09720	COG4166	transmembrane transport
AMD33_RS09725	COG0601	transmembrane transport
AMD33_RS09745	COG0444	Belongs to the ABC transporter superfamily
AMD33_RS09750	COG0444	Belongs to the ABC transporter superfamily
AMD33_RS09770	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AMD33_RS09785	COG1121	(ABC) transporter
AMD33_RS09790	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AMD33_RS09800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AMD33_RS09800	COG2190	(PTS) system
AMD33_RS09800	COG1263	PTS System
AMD33_RS09805	COG2190	(PTS) system
AMD33_RS09805	COG1263	PTS System
AMD33_RS09805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AMD33_RS09810	COG2190	(PTS) system
AMD33_RS09810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AMD33_RS09810	COG1263	PTS System
AMD33_RS09840	COG4589	Belongs to the CDS family