locus-tag	class	description
Y1U_RS00010	COG0592	DNA-directed DNA polymerase activity
Y1U_RS00020	COG0012	GTP binding
Y1U_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Y1U_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Y1U_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Y1U_RS00210	COG3942	CHAP domain
Y1U_RS00225	COG0436	Aminotransferase
Y1U_RS00240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Y1U_RS00250	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Y1U_RS00265	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Y1U_RS00285	COG2801	Transposase and inactivated derivatives
Y1U_RS00290	COG1388	LysM domain
Y1U_RS00290	COG3942	CHAP domain
Y1U_RS00295	COG0151	Belongs to the GarS family
Y1U_RS00300	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Y1U_RS00320	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Y1U_RS00335	COG4550	Control of competence regulator ComK, YlbF/YmcA
Y1U_RS00375	COG2818	Glycosylase
Y1U_RS00385	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Y1U_RS00390	COG1393	Belongs to the ArsC family
Y1U_RS00480	COG2309	aminopeptidase activity
Y1U_RS00495	COG0431	NADPH-dependent FMN reductase
Y1U_RS00530	COG4463	regulation of RNA biosynthetic process
Y1U_RS00535	COG0542	response to heat
Y1U_RS00545	COG1686	Belongs to the peptidase S11 family
Y1U_RS00560	COG1045	serine acetyltransferase
Y1U_RS00570	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
Y1U_RS00585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Y1U_RS00610	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Y1U_RS00670	COG3942	CHAP domain
Y1U_RS00670	COG1705	Flagellar rod assembly protein muramidase FlgJ
Y1U_RS00685	COG3830	Belongs to the UPF0237 family
Y1U_RS00700	COG1876	peptidase activity
Y1U_RS00735	COG0351	phosphomethylpyrimidine kinase
Y1U_RS00770	COG4166	transmembrane transport
Y1U_RS00785	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Y1U_RS00800	COG0668	transmembrane transport
Y1U_RS00815	COG0504	CTP synthase activity
Y1U_RS00825	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Y1U_RS00835	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Y1U_RS00840	COG0737	Belongs to the 5'-nucleotidase family
Y1U_RS00850	COG0737	Belongs to the 5'-nucleotidase family
Y1U_RS00855	COG0737	Belongs to the 5'-nucleotidase family
Y1U_RS00895	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Y1U_RS00925	COG1126	abc transporter atp-binding protein
Y1U_RS00930	COG0765	amino acid transport
Y1U_RS00935	COG1968	undecaprenyl-diphosphatase activity
Y1U_RS00945	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Y1U_RS00955	COG0719	Fe-S assembly protein
Y1U_RS00960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Y1U_RS00970	COG0719	Fe-S assembly protein
Y1U_RS00975	COG4166	transmembrane transport
Y1U_RS00980	COG0601	transmembrane transport
Y1U_RS01000	COG0444	Belongs to the ABC transporter superfamily
Y1U_RS01005	COG0444	Belongs to the ABC transporter superfamily
Y1U_RS01025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Y1U_RS01040	COG1121	(ABC) transporter
Y1U_RS01045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Y1U_RS01055	COG2190	(PTS) system
Y1U_RS01055	COG1263	PTS System
Y1U_RS01055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Y1U_RS01060	COG2190	(PTS) system
Y1U_RS01060	COG1263	PTS System
Y1U_RS01060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Y1U_RS01065	COG2190	(PTS) system
Y1U_RS01065	COG1263	PTS System
Y1U_RS01065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Y1U_RS01095	COG4589	Belongs to the CDS family
Y1U_RS01110	COG4120	Belongs to the binding-protein-dependent transport system permease family
Y1U_RS01115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Y1U_RS01115	COG1116	anion transmembrane transporter activity
Y1U_RS01155	COG2801	Transposase and inactivated derivatives
Y1U_RS01170	COG0564	pseudouridine synthase activity
Y1U_RS01175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Y1U_RS01200	COG1349	DNA-binding transcription factor activity
Y1U_RS01230	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Y1U_RS01245	COG3579	cysteine-type endopeptidase activity
Y1U_RS01255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Y1U_RS01280	COG0116	Belongs to the methyltransferase superfamily
Y1U_RS01290	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Y1U_RS01310	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Y1U_RS01335	COG1254	Belongs to the acylphosphatase family
Y1U_RS01340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Y1U_RS01385	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Y1U_RS01405	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Y1U_RS01410	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Y1U_RS01415	COG1187	pseudouridine synthase activity
Y1U_RS01425	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Y1U_RS01430	COG0569	domain protein
Y1U_RS01440	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
Y1U_RS01445	COG0671	phosphoesterase, PA-phosphatase related
Y1U_RS01465	COG2274	protein secretion by the type I secretion system
Y1U_RS01470	COG2274	protein secretion by the type I secretion system
Y1U_RS01475	COG2274	protein secretion by the type I secretion system
Y1U_RS01525	COG0829	nickel cation binding
Y1U_RS01530	COG0310	cobalt ion transport
Y1U_RS01540	COG1122	ATPase activity
Y1U_RS01545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Y1U_RS01550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Y1U_RS01570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Y1U_RS01575	COG1464	Belongs to the NlpA lipoprotein family
Y1U_RS01610	COG1122	ATPase activity
Y1U_RS01620	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Y1U_RS01630	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Y1U_RS01645	COG0745	RESPONSE REGULATOR receiver
Y1U_RS01650	COG5002	protein histidine kinase activity
Y1U_RS01665	COG1484	DNA-dependent DNA replication
Y1U_RS01680	COG2801	Transposase and inactivated derivatives
Y1U_RS01705	COG3716	PTS system mannose fructose sorbose family IID component
Y1U_RS01710	COG3715	PTS system
Y1U_RS01720	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Y1U_RS01725	COG0561	phosphatase activity
Y1U_RS01730	COG2252	PERMEase
Y1U_RS01735	COG0802	atpase or kinase
Y1U_RS01740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Y1U_RS01745	COG1316	TRANSCRIPTIONal
Y1U_RS01755	COG0195	Participates in both transcription termination and antitermination
Y1U_RS01760	COG2740	Nucleic-acid-binding protein implicated in transcription termination
Y1U_RS01780	COG1611	Belongs to the LOG family
Y1U_RS01800	COG2244	polysaccharide biosynthetic process
Y1U_RS01805	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Y1U_RS01810	COG0626	cystathionine gamma-synthase activity
Y1U_RS01815	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Y1U_RS01840	COG4471	UPF0298 protein
Y1U_RS01850	COG0559	Belongs to the binding-protein-dependent transport system permease family
Y1U_RS01870	COG0517	IMP dehydrogenase activity
Y1U_RS01885	COG1739	Uncharacterized protein family UPF0029
Y1U_RS01890	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
Y1U_RS01895	COG1040	competence protein
Y1U_RS01985	COG0527	aspartate kinase activity
Y1U_RS01990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Y1U_RS01995	COG1024	Enoyl-CoA hydratase
Y1U_RS02000	COG1846	Transcriptional regulator
Y1U_RS02020	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Y1U_RS02025	COG1028	Short-chain dehydrogenase reductase Sdr
Y1U_RS02030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Y1U_RS02045	COG0439	Biotin carboxylase
Y1U_RS02100	COG2801	Transposase and inactivated derivatives
Y1U_RS02105	COG2963	transposase activity
Y1U_RS02120	COG1349	DNA-binding transcription factor activity
Y1U_RS02125	COG1105	Belongs to the carbohydrate kinase PfkB family
Y1U_RS02135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Y1U_RS02140	COG0285	dihydrofolate synthase activity
Y1U_RS02150	COG1104	cysteine desulfurase activity
Y1U_RS02215	COG0488	(ABC) transporter
Y1U_RS02235	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Y1U_RS02240	COG0242	peptide deformylase activity
Y1U_RS02300	COG1702	phosphate starvation-inducible protein PhoH
Y1U_RS02320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Y1U_RS02320	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Y1U_RS02345	COG4122	O-methyltransferase activity
Y1U_RS02350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Y1U_RS02375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Y1U_RS02380	COG0436	Aminotransferase
Y1U_RS02395	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Y1U_RS02400	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Y1U_RS02405	COG0726	polysaccharide deacetylase
Y1U_RS02420	COG2962	Rard protein
Y1U_RS02460	COG0356	it plays a direct role in the translocation of protons across the membrane
Y1U_RS02495	COG0772	Belongs to the SEDS family
Y1U_RS02515	COG0470	DNA polymerase III
Y1U_RS02520	COG1774	PSP1 C-terminal conserved region
Y1U_RS02525	COG4467	Involved in initiation control of chromosome replication
Y1U_RS02535	COG0004	ammonium transporteR
Y1U_RS02540	COG0347	Belongs to the P(II) protein family
Y1U_RS02545	COG1388	LysM domain
Y1U_RS02545	COG1705	Flagellar rod assembly protein muramidase FlgJ
Y1U_RS02600	COG1113	amino acid transport
Y1U_RS02610	COG2190	(PTS) system
Y1U_RS02610	COG1263	PTS System
Y1U_RS02610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Y1U_RS02625	COG2801	Transposase and inactivated derivatives
Y1U_RS02655	COG0583	DNA-binding transcription factor activity
Y1U_RS02665	COG0564	pseudouridine synthase activity
Y1U_RS02685	COG0505	Belongs to the CarA family
Y1U_RS02720	COG3328	transposase activity
Y1U_RS02750	COG3279	Response regulator of the LytR AlgR family
Y1U_RS02760	COG1131	(ABC) transporter
Y1U_RS02795	COG1187	pseudouridine synthase activity
Y1U_RS02800	COG1473	amidohydrolase
Y1U_RS02805	COG0686	Belongs to the AlaDH PNT family
Y1U_RS02810	COG0686	Belongs to the AlaDH PNT family
Y1U_RS02815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Y1U_RS02880	COG0438	transferase activity, transferring glycosyl groups
Y1U_RS02910	COG1272	protein, Hemolysin III
Y1U_RS02925	COG3425	synthase
Y1U_RS02935	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Y1U_RS02955	COG0833	amino acid
Y1U_RS02960	COG2040	homocysteine
Y1U_RS02980	COG0187	DNA topoisomerase II activity
Y1U_RS02990	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Y1U_RS03010	COG0539	negative regulation of cytoplasmic translation
Y1U_RS03035	COG0673	inositol 2-dehydrogenase activity
Y1U_RS03050	COG0494	nUDIX hydrolase
Y1U_RS03055	COG0542	response to heat
Y1U_RS03060	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Y1U_RS03065	COG4703	Protein of unknown function (DUF1797)
Y1U_RS03070	COG0765	amino acid transport
Y1U_RS03120	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Y1U_RS03125	COG0768	penicillin binding
Y1U_RS03130	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Y1U_RS03140	COG3711	transcriptional antiterminator
Y1U_RS03150	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Y1U_RS03155	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Y1U_RS03160	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Y1U_RS03165	COG0237	dephospho-CoA kinase activity
Y1U_RS03170	COG2814	Major facilitator Superfamily
Y1U_RS03180	COG0557	exoribonuclease II activity
Y1U_RS03195	COG1185	polyribonucleotide nucleotidyltransferase activity
Y1U_RS03200	COG0006	proline dipeptidase activity
Y1U_RS03205	COG1609	Transcriptional regulator
Y1U_RS03235	COG1368	sulfuric ester hydrolase activity
Y1U_RS03240	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Y1U_RS03265	COG0287	Prephenate dehydrogenase
Y1U_RS03290	COG0077	Prephenate dehydratase
Y1U_RS03350	COG1518	maintenance of DNA repeat elements
Y1U_RS03355	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Y1U_RS03365	COG3689	TIGRFAM TIGR03943 family protein
Y1U_RS03370	COG0701	Predicted permease
Y1U_RS03375	COG2183	response to ionizing radiation
Y1U_RS03420	COG0826	peptidase U32
Y1U_RS03425	COG1268	BioY protein
Y1U_RS03435	COG4443	Transcriptional Coactivator p15 (PC4)
Y1U_RS03440	COG1914	H( )-stimulated, divalent metal cation uptake system
Y1U_RS03475	COG1388	LysM domain
Y1U_RS03475	COG1705	Flagellar rod assembly protein muramidase FlgJ
Y1U_RS03490	COG0406	alpha-ribazole phosphatase activity
Y1U_RS03495	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Y1U_RS03530	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Y1U_RS03550	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
Y1U_RS03555	COG3620	sequence-specific DNA binding
Y1U_RS03575	COG1704	LemA family
Y1U_RS03580	COG0501	Belongs to the peptidase M48B family
Y1U_RS03595	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Y1U_RS03605	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Y1U_RS03620	COG0783	Belongs to the Dps family
Y1U_RS03625	COG0735	belongs to the Fur family
Y1U_RS03630	COG4483	Protein conserved in bacteria
Y1U_RS03635	COG1940	carbohydrate kinase activity
Y1U_RS03640	COG1217	gtp-binding protein TYPA
Y1U_RS03675	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Y1U_RS03695	COG3599	regulation of cell shape
Y1U_RS03730	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Y1U_RS03735	COG0625	glutathione transferase activity
Y1U_RS03740	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Y1U_RS03755	COG2890	protein-(glutamine-N5) methyltransferase activity
Y1U_RS03785	COG1132	(ABC) transporter
Y1U_RS03800	COG1696	Membrane protein involved in D-alanine export
Y1U_RS03810	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
Y1U_RS03820	COG2801	Transposase and inactivated derivatives
Y1U_RS03840	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Y1U_RS03845	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Y1U_RS03910	COG1396	sequence-specific DNA binding
Y1U_RS03915	COG0582	viral genome integration into host DNA
Y1U_RS03970	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Y1U_RS03995	COG0765	amino acid transport
Y1U_RS04000	COG0765	amino acid transport
Y1U_RS04005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Y1U_RS04010	COG1126	abc transporter atp-binding protein
Y1U_RS04015	COG0745	RESPONSE REGULATOR receiver
Y1U_RS04020	COG5002	protein histidine kinase activity
Y1U_RS04025	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Y1U_RS04035	COG2348	transferase activity, transferring amino-acyl groups
Y1U_RS04070	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Y1U_RS04075	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Y1U_RS04080	COG2884	Cell division ATP-binding protein ftsE
Y1U_RS04085	COG2177	Part of the ABC transporter FtsEX involved in
Y1U_RS04090	COG1051	belongs to the nudix hydrolase family
Y1U_RS04095	COG0628	permease
Y1U_RS04105	COG0681	Belongs to the peptidase S26 family
Y1U_RS04170	COG1573	uracil-dna glycosylase
Y1U_RS04190	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Y1U_RS04215	COG1316	TRANSCRIPTIONal
Y1U_RS04255	COG0562	UDP-galactopyranose mutase
Y1U_RS04265	COG1442	glycosyl transferase family 8
Y1U_RS04265	COG1216	Glycosyl transferase, family 2
Y1U_RS04275	COG1091	dTDP-4-dehydrorhamnose reductase activity
Y1U_RS04325	COG1316	TRANSCRIPTIONal
Y1U_RS04330	COG2801	Transposase and inactivated derivatives
Y1U_RS04335	COG2963	transposase activity
Y1U_RS04360	COG2244	polysaccharide biosynthetic process
Y1U_RS04365	COG1216	Glycosyl transferase, family 2
Y1U_RS04365	COG1442	glycosyl transferase family 8
Y1U_RS04370	COG2801	Transposase and inactivated derivatives
Y1U_RS04375	COG2963	transposase activity
Y1U_RS04380	COG0438	transferase activity, transferring glycosyl groups
Y1U_RS04395	COG0628	permease
Y1U_RS04410	COG2723	6-phospho-beta-galactosidase activity
Y1U_RS04435	COG4667	esterase of the alpha-beta hydrolase superfamily
Y1U_RS04440	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Y1U_RS04475	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Y1U_RS04480	COG0508	dehydrogenase complex catalyzes the overall conversion of
Y1U_RS04480	COG0022	dehydrogenase e1 component
Y1U_RS04485	COG0508	dehydrogenase complex catalyzes the overall conversion of
Y1U_RS04510	COG1523	belongs to the glycosyl hydrolase 13 family
Y1U_RS04520	COG1523	belongs to the glycosyl hydrolase 13 family
Y1U_RS04530	COG2822	iron ion transport
Y1U_RS04535	COG2837	iron assimilation
Y1U_RS04540	COG0672	)-iron permease
Y1U_RS04545	COG0805	protein transport
Y1U_RS04550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Y1U_RS04565	COG1640	4-alpha-glucanotransferase
Y1U_RS04570	COG0058	SHG alpha-glucan phosphorylase activity
Y1U_RS04585	COG0095	Lipoate-protein ligase
Y1U_RS04600	COG0704	Plays a role in the regulation of phosphate uptake
Y1U_RS04615	COG0581	inorganic phosphate transmembrane transporter activity
Y1U_RS04620	COG0573	inorganic phosphate transmembrane transporter activity
Y1U_RS04630	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Y1U_RS04630	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Y1U_RS04635	COG0483	inositol monophosphate 1-phosphatase activity
Y1U_RS04645	COG1393	Belongs to the ArsC family
Y1U_RS04650	COG0196	riboflavin kinase activity
Y1U_RS04655	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Y1U_RS04685	COG2873	o-acetylhomoserine
Y1U_RS04695	COG1115	amino acid carrier protein
Y1U_RS04725	COG0737	Belongs to the 5'-nucleotidase family
Y1U_RS04735	COG0765	amino acid transport
Y1U_RS04740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Y1U_RS04745	COG0154	amidase activity
Y1U_RS04750	COG3104	oligopeptide transport
Y1U_RS04765	COG0284	orotidine-5'-phosphate decarboxylase activity
Y1U_RS04780	COG1567	CRISPR-associated RAMP protein, Csm4 family
Y1U_RS04785	COG1337	RAMP superfamily
Y1U_RS04805	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Y1U_RS04815	COG0167	dihydroorotate dehydrogenase activity
Y1U_RS04825	COG0047	phosphoribosylformylglycinamidine synthase activity
Y1U_RS04855	COG1293	RNA-binding protein homologous to eukaryotic snRNP
Y1U_RS04875	COG4607	ABC-type enterochelin transport system periplasmic component
Y1U_RS04880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Y1U_RS04905	COG1063	alcohol dehydrogenase
Y1U_RS04915	COG1230	cation diffusion facilitator family transporter
Y1U_RS04945	COG3527	Alpha-acetolactate decarboxylase
Y1U_RS04950	COG0028	Belongs to the TPP enzyme family
Y1U_RS04960	COG0010	Belongs to the arginase family
Y1U_RS04965	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Y1U_RS04975	COG1396	sequence-specific DNA binding
Y1U_RS04980	COG0481	GTPase activity
Y1U_RS05005	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Y1U_RS05025	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Y1U_RS05030	COG0758	DNA mediated transformation
Y1U_RS05035	COG1940	carbohydrate kinase activity
Y1U_RS05045	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
Y1U_RS05055	COG1827	regulation of RNA biosynthetic process
Y1U_RS05065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Y1U_RS05075	COG2188	Transcriptional regulator
Y1U_RS05080	COG0519	Catalyzes the synthesis of GMP from XMP
Y1U_RS05080	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Y1U_RS05085	COG2189	Belongs to the N(4) N(6)-methyltransferase family
Y1U_RS05090	COG1064	alcohol dehydrogenase
Y1U_RS05105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Y1U_RS05110	COG1126	abc transporter atp-binding protein
Y1U_RS05115	COG0765	amino acid transport
Y1U_RS05120	COG2824	Alkylphosphonate utilization operon protein PhnA
Y1U_RS05125	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Y1U_RS05140	COG1705	Flagellar rod assembly protein muramidase FlgJ
Y1U_RS05140	COG3942	CHAP domain
Y1U_RS05155	COG0803	Belongs to the bacterial solute-binding protein 9 family
Y1U_RS05155	COG3443	Belongs to the bacterial solute-binding protein 9 family
Y1U_RS05175	COG4975	Glucose uptake
Y1U_RS05180	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Y1U_RS05200	COG1045	serine acetyltransferase
Y1U_RS05205	COG0626	cystathionine gamma-synthase activity
Y1U_RS05210	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Y1U_RS05225	COG2217	Heavy metal translocating P-type atpase
Y1U_RS05240	COG1278	Cold shock
Y1U_RS05285	COG0720	synthase
Y1U_RS05295	COG0251	oxidation-reduction process
Y1U_RS05325	COG0017	Asparaginyl-tRNA synthetase
Y1U_RS05330	COG0436	Aminotransferase
Y1U_RS05340	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Y1U_RS05340	COG1199	ATP-dependent helicase activity
Y1U_RS05350	COG1079	Belongs to the binding-protein-dependent transport system permease family
Y1U_RS05355	COG4603	Belongs to the binding-protein-dependent transport system permease family
Y1U_RS05360	COG3845	ABC transporter
Y1U_RS05365	COG1744	ABC transporter substrate-binding protein PnrA-like
Y1U_RS05370	COG0295	cytidine deaminase activity
Y1U_RS05380	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
Y1U_RS05390	COG2813	Specifically methylates the guanine in position
Y1U_RS05405	COG2801	Transposase and inactivated derivatives
Y1U_RS05425	COG0038	chloride channel
Y1U_RS05445	COG2801	Transposase and inactivated derivatives
Y1U_RS05455	COG5002	protein histidine kinase activity
Y1U_RS05460	COG5002	protein histidine kinase activity
Y1U_RS05485	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Y1U_RS05490	COG4684	Psort location CytoplasmicMembrane, score
Y1U_RS05495	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Y1U_RS05515	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Y1U_RS05520	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Y1U_RS05520	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Y1U_RS05530	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Y1U_RS05535	COG1956	GAF domain-containing protein
Y1U_RS05540	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Y1U_RS05550	COG0335	large ribosomal subunit rRNA binding
Y1U_RS05555	COG0038	chloride channel
Y1U_RS05565	COG0038	chloride channel
Y1U_RS05570	COG0716	FMN binding
Y1U_RS05650	COG0469	pyruvate kinase activity
Y1U_RS05700	COG0167	dihydroorotate dehydrogenase activity
Y1U_RS05710	COG0776	regulation of translation
Y1U_RS05720	COG2755	lipolytic protein G-D-S-L family
Y1U_RS05725	COG1307	EDD domain protein, DegV family
Y1U_RS05730	COG0497	DNA recombination
Y1U_RS05735	COG1438	arginine binding
Y1U_RS05740	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Y1U_RS05765	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Y1U_RS05785	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Y1U_RS05785	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Y1U_RS05790	COG0300	oxidoreductase activity
Y1U_RS05805	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Y1U_RS05810	COG0772	Belongs to the SEDS family
Y1U_RS05825	COG0107	imidazoleglycerol-phosphate synthase activity
Y1U_RS05835	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Y1U_RS05845	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Y1U_RS05870	COG2801	Transposase and inactivated derivatives
Y1U_RS05875	COG2801	Transposase and inactivated derivatives
Y1U_RS05910	COG0647	UMP catabolic process
Y1U_RS05920	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Y1U_RS05945	COG1088	dTDP-glucose 4,6-dehydratase activity
Y1U_RS05955	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
Y1U_RS05960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Y1U_RS05975	COG2384	SAM-dependent methyltransferase
Y1U_RS06000	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Y1U_RS06005	COG3442	glutamine amidotransferase
Y1U_RS06010	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
Y1U_RS06010	COG0392	lysyltransferase activity
Y1U_RS06025	COG0488	(ABC) transporter
Y1U_RS06035	COG0513	Belongs to the DEAD box helicase family
Y1U_RS06070	COG0372	Belongs to the citrate synthase family
Y1U_RS06075	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Y1U_RS06080	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Y1U_RS06085	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Y1U_RS06090	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Y1U_RS06120	COG3764	Sortase (surface protein transpeptidase)
Y1U_RS06140	COG0488	(ABC) transporter
Y1U_RS06170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Y1U_RS06175	COG1328	CTP reductase activity
Y1U_RS06175	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Y1U_RS06210	COG1196	nuclear chromosome segregation
Y1U_RS06225	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Y1U_RS06245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Y1U_RS06255	COG1011	Hydrolase
Y1U_RS06265	COG0517	IMP dehydrogenase activity
Y1U_RS06265	COG1125	glycine betaine transport
Y1U_RS06280	COG2986	histidine ammonia-lyase
Y1U_RS06290	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Y1U_RS06295	COG1760	l-serine dehydratase
Y1U_RS06325	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Y1U_RS06335	COG2197	response regulator
Y1U_RS06340	COG4585	Histidine kinase
Y1U_RS06350	COG1131	(ABC) transporter
Y1U_RS06365	COG0385	Bile acid
Y1U_RS06380	COG1131	(ABC) transporter
Y1U_RS06400	COG0577	efflux transmembrane transporter activity
Y1U_RS06405	COG1136	(ABC) transporter
Y1U_RS06410	COG0784	Response regulator, receiver
Y1U_RS06410	COG2198	Histidine kinase
Y1U_RS06410	COG5002	protein histidine kinase activity
Y1U_RS06415	COG0745	RESPONSE REGULATOR receiver
Y1U_RS06425	COG2233	PERMEase
Y1U_RS06430	COG2233	PERMEase
Y1U_RS06435	COG0534	Mate efflux family protein
Y1U_RS06440	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Y1U_RS06440	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Y1U_RS06450	COG1482	cell wall glycoprotein biosynthetic process
Y1U_RS06455	COG1482	cell wall glycoprotein biosynthetic process
Y1U_RS06465	COG0531	amino acid
Y1U_RS06475	COG2514	catechol 2,3-dioxygenase activity
Y1U_RS06480	COG1959	2 iron, 2 sulfur cluster binding
Y1U_RS06490	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Y1U_RS06495	COG0778	Nitroreductase
Y1U_RS06505	COG0656	L-ascorbic acid biosynthetic process
Y1U_RS06510	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Y1U_RS06525	COG0745	RESPONSE REGULATOR receiver
Y1U_RS06550	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Y1U_RS06570	COG1280	lysine exporter protein (LysE YggA)
Y1U_RS06580	COG1442	glycosyl transferase family 8
Y1U_RS06580	COG1216	Glycosyl transferase, family 2
Y1U_RS06585	COG0577	efflux transmembrane transporter activity
Y1U_RS06630	COG1396	sequence-specific DNA binding
Y1U_RS06635	COG2801	Transposase and inactivated derivatives
Y1U_RS06650	COG0419	ATPase involved in DNA repair
Y1U_RS06655	COG0420	3'-5' exonuclease activity
Y1U_RS06660	COG3250	beta-galactosidase activity
Y1U_RS06665	COG2190	(PTS) system
Y1U_RS06665	COG2211	Major facilitator Superfamily
Y1U_RS06670	COG2017	converts alpha-aldose to the beta-anomer
Y1U_RS06675	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Y1U_RS06690	COG1609	Transcriptional regulator
Y1U_RS06705	COG3064	Membrane
Y1U_RS06710	COG0488	(ABC) transporter
Y1U_RS06770	COG2197	response regulator
Y1U_RS06775	COG4585	Histidine kinase
Y1U_RS06785	COG2815	serine threonine protein kinase
Y1U_RS06785	COG0515	serine threonine protein kinase
Y1U_RS06795	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Y1U_RS06795	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Y1U_RS06805	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Y1U_RS06820	COG0552	protein localization to endoplasmic reticulum
Y1U_RS06825	COG0561	phosphatase activity
Y1U_RS06830	COG0561	phosphatase activity
Y1U_RS06835	COG1725	Transcriptional regulator
Y1U_RS06840	COG1131	(ABC) transporter
Y1U_RS06850	COG4608	Belongs to the ABC transporter superfamily
Y1U_RS06855	COG0444	Belongs to the ABC transporter superfamily
Y1U_RS06860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Y1U_RS06865	COG0601	transmembrane transport
Y1U_RS06870	COG4166	transmembrane transport
Y1U_RS06880	COG4166	transmembrane transport
Y1U_RS06890	COG2801	Transposase and inactivated derivatives
Y1U_RS06895	COG4608	Belongs to the ABC transporter superfamily
Y1U_RS06900	COG0084	hydrolase, TatD family'
Y1U_RS06905	COG2223	nitrite transmembrane transporter activity
Y1U_RS06910	COG2801	Transposase and inactivated derivatives
Y1U_RS06920	COG0280	phosphate acetyltransferase
Y1U_RS06925	COG0564	pseudouridine synthase activity
Y1U_RS06935	COG2357	RelA SpoT domain protein
Y1U_RS06950	COG1104	cysteine desulfurase activity
Y1U_RS06965	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Y1U_RS06970	COG2003	Belongs to the UPF0758 family
Y1U_RS06995	COG1215	transferase activity, transferring glycosyl groups
Y1U_RS07005	COG1442	glycosyl transferase family 8
Y1U_RS07005	COG1216	Glycosyl transferase, family 2
Y1U_RS07025	COG1091	dTDP-4-dehydrorhamnose reductase activity
Y1U_RS07035	COG0463	Glycosyl transferase, family 2
Y1U_RS07045	COG2151	metal-sulfur cluster biosynthetic enzyme
Y1U_RS07050	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Y1U_RS07055	COG0358	DNA primase activity
Y1U_RS07060	COG1970	mechanosensitive ion channel activity
Y1U_RS07070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Y1U_RS07075	COG0436	Aminotransferase
Y1U_RS07080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Y1U_RS07085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Y1U_RS07090	COG1051	belongs to the nudix hydrolase family
Y1U_RS07115	COG0765	amino acid transport
Y1U_RS07120	COG1126	abc transporter atp-binding protein
Y1U_RS07135	COG1187	pseudouridine synthase activity
Y1U_RS07180	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Y1U_RS07185	COG1518	maintenance of DNA repeat elements
Y1U_RS07190	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
Y1U_RS07195	COG0560	Phosphoserine phosphatase
Y1U_RS07205	COG0187	DNA topoisomerase II activity
Y1U_RS07215	COG1346	cytolysis
Y1U_RS07220	COG1380	Effector of murein hydrolase LrgA
Y1U_RS07230	COG1393	Belongs to the ArsC family
Y1U_RS07240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Y1U_RS07255	COG1940	carbohydrate kinase activity
Y1U_RS07280	COG1177	transmembrane transport
Y1U_RS07285	COG1176	ABC-type spermidine putrescine transport system, permease component I
Y1U_RS07325	COG0531	amino acid
Y1U_RS07330	COG0285	dihydrofolate synthase activity
Y1U_RS07335	COG1837	Belongs to the UPF0109 family
Y1U_RS07345	COG0500	methyltransferase
Y1U_RS07345	COG3615	Tellurite resistance protein tehB
Y1U_RS07355	COG0708	Exodeoxyribonuclease III
Y1U_RS07370	COG1597	lipid kinase activity
Y1U_RS07380	COG4708	membrane
Y1U_RS07390	COG0024	Methionine aminopeptidase
Y1U_RS07395	COG4109	DRTGG domain
Y1U_RS07405	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Y1U_RS07410	COG0658	competence protein
Y1U_RS07410	COG2333	competence protein COMEC
Y1U_RS07415	COG1555	photosystem II stabilization
Y1U_RS07415	COG1596	polysaccharide export
Y1U_RS07420	COG0204	Acyl-transferase
Y1U_RS07430	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Y1U_RS07440	COG0513	Belongs to the DEAD box helicase family
Y1U_RS07460	COG1396	sequence-specific DNA binding
Y1U_RS07465	COG2211	Major facilitator Superfamily
Y1U_RS07480	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Y1U_RS07495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Y1U_RS07500	COG1126	abc transporter atp-binding protein
Y1U_RS07505	COG0765	amino acid transport
Y1U_RS07510	COG0765	amino acid transport
Y1U_RS07525	COG2217	Heavy metal translocating P-type atpase
Y1U_RS07535	COG0159	tryptophan synthase activity
Y1U_RS07545	COG0135	phosphoribosylanthranilate isomerase activity
Y1U_RS07560	COG0512	Glutamine amidotransferase of anthranilate synthase
Y1U_RS07565	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Y1U_RS07570	COG0287	Prephenate dehydrogenase
Y1U_RS07570	COG1605	Chorismate mutase
Y1U_RS07580	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Y1U_RS07605	COG2176	DNA-directed DNA polymerase activity
Y1U_RS07615	COG2151	metal-sulfur cluster biosynthetic enzyme
Y1U_RS07625	COG2081	HI0933 family
Y1U_RS07650	COG1131	(ABC) transporter
Y1U_RS07655	COG0537	adenosine 5'-monophosphoramidase activity
Y1U_RS07685	COG2226	methyltransferase
Y1U_RS07690	COG0799	negative regulation of ribosome biogenesis
Y1U_RS07695	COG1713	HD superfamily hydrolase involved in NAD metabolism
Y1U_RS07700	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Y1U_RS07705	COG1534	Rna-binding protein
Y1U_RS07710	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
Y1U_RS07715	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
Y1U_RS07765	COG1335	isochorismatase
Y1U_RS07775	COG0436	Aminotransferase
Y1U_RS07780	COG0589	response to stress
Y1U_RS07795	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Y1U_RS07800	COG1253	flavin adenine dinucleotide binding
Y1U_RS07805	COG1119	ATPase activity
Y1U_RS07810	COG0025	NhaP-type Na H and K H
Y1U_RS07820	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
Y1U_RS07825	COG1242	4 iron, 4 sulfur cluster binding
Y1U_RS07830	COG3480	Lon protease (S16) C-terminal proteolytic domain
Y1U_RS07835	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Y1U_RS07840	COG0742	ribosomal rna small subunit methyltransferase
Y1U_RS07845	COG0492	ferredoxin-NADP+ reductase activity
Y1U_RS07855	COG1126	abc transporter atp-binding protein
Y1U_RS07865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Y1U_RS07880	COG1882	Formate acetyltransferase
Y1U_RS07905	COG0390	transport system, permease component
Y1U_RS07910	COG4619	ABC transporter
Y1U_RS07915	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Y1U_RS07930	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Y1U_RS07965	COG2801	Transposase and inactivated derivatives
Y1U_RS08015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Y1U_RS08020	COG2274	protein secretion by the type I secretion system
Y1U_RS08025	COG1132	(ABC) transporter
Y1U_RS08030	COG1132	(ABC) transporter
Y1U_RS08050	COG4470	Protein conserved in bacteria
Y1U_RS08055	COG0737	Belongs to the 5'-nucleotidase family
Y1U_RS08060	COG0513	Belongs to the DEAD box helicase family
Y1U_RS08070	COG0768	penicillin binding
Y1U_RS08100	COG3152	Membrane
Y1U_RS08105	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Y1U_RS08120	COG4152	abc transporter atp-binding protein
Y1U_RS08125	COG1811	Na channel or pump
Y1U_RS08130	COG1074	ATP-dependent DNA helicase activity
Y1U_RS08165	COG0561	phosphatase activity
Y1U_RS08170	COG0252	asparaginase activity
Y1U_RS08175	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Y1U_RS08180	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Y1U_RS08190	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Y1U_RS08195	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Y1U_RS08210	COG1482	cell wall glycoprotein biosynthetic process
Y1U_RS08215	COG1940	carbohydrate kinase activity
Y1U_RS08220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Y1U_RS08220	COG2190	(PTS) system
Y1U_RS08220	COG1263	PTS System
Y1U_RS08225	COG1621	beta-fructofuranosidase activity
Y1U_RS08230	COG1609	Transcriptional regulator
Y1U_RS08250	COG2131	deaminase
Y1U_RS08255	COG0006	proline dipeptidase activity
Y1U_RS08270	COG1131	(ABC) transporter
Y1U_RS08345	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Y1U_RS08345	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Y1U_RS08370	COG0681	Belongs to the peptidase S26 family
Y1U_RS08375	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Y1U_RS08385	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Y1U_RS08395	COG0456	acetyltransferase
Y1U_RS08400	COG1214	PFAM Peptidase M22, glycoprotease
Y1U_RS08420	COG0174	glutamine synthetase
Y1U_RS08425	COG0789	Transcriptional regulator
Y1U_RS08465	COG2801	Transposase and inactivated derivatives
Y1U_RS08470	COG2801	Transposase and inactivated derivatives
Y1U_RS08500	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Y1U_RS08545	COG0084	hydrolase, TatD family'
Y1U_RS08550	COG1832	CoA-binding protein
Y1U_RS08555	COG3118	belongs to the thioredoxin family
Y1U_RS08620	COG0706	membrane insertase activity
Y1U_RS08685	COG0756	dUTP diphosphatase activity
Y1U_RS08720	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Y1U_RS08725	COG0457	Tetratricopeptide repeat
Y1U_RS08725	COG0705	Rhomboid family
Y1U_RS08730	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Y1U_RS08750	COG2226	methyltransferase
Y1U_RS08775	COG0425	Belongs to the sulfur carrier protein TusA family
Y1U_RS08780	COG2391	methyltransferase activity
Y1U_RS08785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Y1U_RS08790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Y1U_RS08800	COG1363	Peptidase, m42
Y1U_RS08805	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Y1U_RS08810	COG1266	CAAX protease self-immunity
Y1U_RS08865	COG1459	type II secretion system
Y1U_RS08870	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Y1U_RS08905	COG0440	acetolactate synthase activity
Y1U_RS08910	COG0028	Belongs to the TPP enzyme family
Y1U_RS08915	COG0129	dihydroxy-acid dehydratase activity
Y1U_RS08920	COG1461	Dihydroxyacetone kinase
Y1U_RS08930	COG0534	Mate efflux family protein
Y1U_RS08950	COG1454	alcohol dehydrogenase
Y1U_RS08950	COG1012	belongs to the aldehyde dehydrogenase family
Y1U_RS08955	COG1454	alcohol dehydrogenase
Y1U_RS08955	COG1012	belongs to the aldehyde dehydrogenase family
Y1U_RS08960	COG1012	belongs to the aldehyde dehydrogenase family
Y1U_RS08960	COG1454	alcohol dehydrogenase
Y1U_RS08965	COG3590	peptidase
Y1U_RS08970	COG0366	Alpha amylase catalytic
Y1U_RS08975	COG0366	Alpha amylase catalytic
Y1U_RS08980	COG0366	Alpha amylase catalytic
Y1U_RS08990	COG1609	Transcriptional regulator
Y1U_RS08995	COG2188	Transcriptional regulator
Y1U_RS09000	COG4475	Protein of unknown function (DUF436)
Y1U_RS09030	COG1301	dicarboxylic acid transport
Y1U_RS09100	COG0191	fructose-bisphosphate aldolase activity
Y1U_RS09160	COG0201	protein transport
Y1U_RS09305	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Y1U_RS09320	COG0515	serine threonine protein kinase
Y1U_RS09325	COG1132	(ABC) transporter
Y1U_RS09330	COG1396	sequence-specific DNA binding
Y1U_RS09340	COG1132	(ABC) transporter
Y1U_RS09360	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Y1U_RS09390	COG1328	CTP reductase activity
Y1U_RS09400	COG0602	queuosine metabolic process
Y1U_RS09410	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Y1U_RS09430	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Y1U_RS09435	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Y1U_RS09445	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Y1U_RS09470	COG2261	transglycosylase associated protein
Y1U_RS09490	COG3237	CsbD-like
Y1U_RS09510	COG1511	domain protein
Y1U_RS09510	COG1511	domain protein
Y1U_RS09520	COG3759	membrane
Y1U_RS09535	COG0305	Participates in initiation and elongation during chromosome replication
Y1U_RS09555	COG0494	nUDIX hydrolase
Y1U_RS09570	COG0741	lytic transglycosylase activity
Y1U_RS09575	COG3584	3D domain protein
Y1U_RS09575	COG1388	LysM domain
Y1U_RS09580	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Y1U_RS09595	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Y1U_RS09605	COG0612	Peptidase, M16
Y1U_RS09635	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Y1U_RS09640	COG0488	(ABC) transporter
Y1U_RS09675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Y1U_RS09680	COG1475	DNA binding
Y1U_RS09695	COG0588	phosphoglycerate mutase activity
Y1U_RS09755	COG4166	transmembrane transport
Y1U_RS09760	COG4166	transmembrane transport