locus-tag	class	description
D1O36_RS00010	COG0592	DNA-directed DNA polymerase activity
D1O36_RS00020	COG0012	GTP binding
D1O36_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D1O36_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1O36_RS00205	COG4372	Transposase
D1O36_RS00220	COG4372	Transposase
D1O36_RS00240	COG3942	CHAP domain
D1O36_RS00255	COG0436	Aminotransferase
D1O36_RS00270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1O36_RS00280	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D1O36_RS00295	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D1O36_RS00315	COG0151	Belongs to the GarS family
D1O36_RS00320	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D1O36_RS00340	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D1O36_RS00355	COG4550	Control of competence regulator ComK, YlbF/YmcA
D1O36_RS00395	COG2818	Glycosylase
D1O36_RS00410	COG1393	Belongs to the ArsC family
D1O36_RS00500	COG2309	aminopeptidase activity
D1O36_RS00515	COG0431	NADPH-dependent FMN reductase
D1O36_RS00530	COG1619	proteins homologs of microcin C7 resistance protein MccF
D1O36_RS00555	COG4463	regulation of RNA biosynthetic process
D1O36_RS00560	COG0542	response to heat
D1O36_RS00575	COG1686	Belongs to the peptidase S11 family
D1O36_RS00590	COG1045	serine acetyltransferase
D1O36_RS00600	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
D1O36_RS00640	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D1O36_RS00685	COG3830	Belongs to the UPF0237 family
D1O36_RS00695	COG0588	phosphoglycerate mutase activity
D1O36_RS00700	COG1876	peptidase activity
D1O36_RS00735	COG0351	phosphomethylpyrimidine kinase
D1O36_RS00850	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D1O36_RS00870	COG0668	transmembrane transport
D1O36_RS00885	COG0504	CTP synthase activity
D1O36_RS00895	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D1O36_RS00905	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D1O36_RS00945	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D1O36_RS00980	COG1126	abc transporter atp-binding protein
D1O36_RS00985	COG0765	amino acid transport
D1O36_RS01005	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D1O36_RS01015	COG0719	Fe-S assembly protein
D1O36_RS01020	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1O36_RS01030	COG0719	Fe-S assembly protein
D1O36_RS01055	COG4608	Belongs to the ABC transporter superfamily
D1O36_RS01070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D1O36_RS01095	COG1121	(ABC) transporter
D1O36_RS01100	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1O36_RS01140	COG4589	Belongs to the CDS family
D1O36_RS01155	COG4120	Belongs to the binding-protein-dependent transport system permease family
D1O36_RS01160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D1O36_RS01160	COG1116	anion transmembrane transporter activity
D1O36_RS01200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1O36_RS01260	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D1O36_RS01275	COG3579	cysteine-type endopeptidase activity
D1O36_RS01280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1O36_RS01305	COG0116	Belongs to the methyltransferase superfamily
D1O36_RS01335	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D1O36_RS01360	COG1254	Belongs to the acylphosphatase family
D1O36_RS01365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D1O36_RS01405	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D1O36_RS01425	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D1O36_RS01430	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D1O36_RS01435	COG1187	pseudouridine synthase activity
D1O36_RS01450	COG0569	domain protein
D1O36_RS01460	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
D1O36_RS01465	COG0671	phosphoesterase, PA-phosphatase related
D1O36_RS01480	COG2274	protein secretion by the type I secretion system
D1O36_RS01490	COG2274	protein secretion by the type I secretion system
D1O36_RS01550	COG0829	nickel cation binding
D1O36_RS01555	COG0310	cobalt ion transport
D1O36_RS01565	COG1122	ATPase activity
D1O36_RS01570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1O36_RS01580	COG1464	Belongs to the NlpA lipoprotein family
D1O36_RS01590	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D1O36_RS01600	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
D1O36_RS01615	COG1122	ATPase activity
D1O36_RS01625	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D1O36_RS01640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D1O36_RS01655	COG0745	RESPONSE REGULATOR receiver
D1O36_RS01660	COG5002	protein histidine kinase activity
D1O36_RS01675	COG1484	DNA-dependent DNA replication
D1O36_RS01690	COG1335	isochorismatase
D1O36_RS01710	COG3716	PTS system mannose fructose sorbose family IID component
D1O36_RS01715	COG3715	PTS system
D1O36_RS01725	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D1O36_RS01730	COG0561	phosphatase activity
D1O36_RS01735	COG2252	PERMEase
D1O36_RS01740	COG0802	atpase or kinase
D1O36_RS01745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1O36_RS01750	COG1316	TRANSCRIPTIONal
D1O36_RS01760	COG0195	Participates in both transcription termination and antitermination
D1O36_RS01765	COG2740	Nucleic-acid-binding protein implicated in transcription termination
D1O36_RS01800	COG2244	polysaccharide biosynthetic process
D1O36_RS01810	COG0626	cystathionine gamma-synthase activity
D1O36_RS01815	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D1O36_RS01845	COG4471	UPF0298 protein
D1O36_RS01855	COG0559	Belongs to the binding-protein-dependent transport system permease family
D1O36_RS01885	COG1739	Uncharacterized protein family UPF0029
D1O36_RS01890	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
D1O36_RS01895	COG1040	competence protein
D1O36_RS01985	COG0527	aspartate kinase activity
D1O36_RS01990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1O36_RS01995	COG1024	Enoyl-CoA hydratase
D1O36_RS02000	COG1846	Transcriptional regulator
D1O36_RS02020	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D1O36_RS02025	COG1028	Short-chain dehydrogenase reductase Sdr
D1O36_RS02030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1O36_RS02045	COG0439	Biotin carboxylase
D1O36_RS02090	COG1349	DNA-binding transcription factor activity
D1O36_RS02095	COG1105	Belongs to the carbohydrate kinase PfkB family
D1O36_RS02105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1O36_RS02110	COG4372	Transposase
D1O36_RS02130	COG0285	dihydrofolate synthase activity
D1O36_RS02140	COG1104	cysteine desulfurase activity
D1O36_RS02200	COG0488	(ABC) transporter
D1O36_RS02220	COG4372	Transposase
D1O36_RS02240	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D1O36_RS02245	COG0242	peptide deformylase activity
D1O36_RS02300	COG1702	phosphate starvation-inducible protein PhoH
D1O36_RS02320	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1O36_RS02320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1O36_RS02350	COG4122	O-methyltransferase activity
D1O36_RS02355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D1O36_RS02385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D1O36_RS02390	COG0436	Aminotransferase
D1O36_RS02400	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D1O36_RS02405	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D1O36_RS02410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1O36_RS02420	COG3328	transposase activity
D1O36_RS02425	COG1301	dicarboxylic acid transport
D1O36_RS02485	COG0525	valine-tRNA ligase activity
D1O36_RS02495	COG0356	it plays a direct role in the translocation of protons across the membrane
D1O36_RS02530	COG0772	Belongs to the SEDS family
D1O36_RS02550	COG0470	DNA polymerase III
D1O36_RS02555	COG1774	PSP1 C-terminal conserved region
D1O36_RS02560	COG4467	Involved in initiation control of chromosome replication
D1O36_RS02570	COG0004	ammonium transporteR
D1O36_RS02575	COG0347	Belongs to the P(II) protein family
D1O36_RS02580	COG1705	Flagellar rod assembly protein muramidase FlgJ
D1O36_RS02580	COG1388	LysM domain
D1O36_RS02630	COG1113	amino acid transport
D1O36_RS02645	COG1263	PTS System
D1O36_RS02645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D1O36_RS02645	COG2190	(PTS) system
D1O36_RS02680	COG0583	DNA-binding transcription factor activity
D1O36_RS02690	COG0564	pseudouridine synthase activity
D1O36_RS02710	COG0505	Belongs to the CarA family
D1O36_RS02760	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D1O36_RS02775	COG3279	Response regulator of the LytR AlgR family
D1O36_RS02785	COG1131	(ABC) transporter
D1O36_RS02820	COG1187	pseudouridine synthase activity
D1O36_RS02825	COG1473	amidohydrolase
D1O36_RS02830	COG0686	Belongs to the AlaDH PNT family
D1O36_RS02835	COG0686	Belongs to the AlaDH PNT family
D1O36_RS02840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1O36_RS02905	COG0438	transferase activity, transferring glycosyl groups
D1O36_RS02945	COG1272	protein, Hemolysin III
D1O36_RS02960	COG3425	synthase
D1O36_RS02970	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D1O36_RS02995	COG2040	homocysteine
D1O36_RS03045	COG0539	negative regulation of cytoplasmic translation
D1O36_RS03085	COG0494	nUDIX hydrolase
D1O36_RS03090	COG0542	response to heat
D1O36_RS03095	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D1O36_RS03100	COG4703	Protein of unknown function (DUF1797)
D1O36_RS03105	COG0765	amino acid transport
D1O36_RS03145	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D1O36_RS03150	COG0768	penicillin binding
D1O36_RS03155	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D1O36_RS03180	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D1O36_RS03185	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D1O36_RS03190	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D1O36_RS03195	COG0237	dephospho-CoA kinase activity
D1O36_RS03200	COG2814	Major facilitator Superfamily
D1O36_RS03215	COG0557	exoribonuclease II activity
D1O36_RS03230	COG1185	polyribonucleotide nucleotidyltransferase activity
D1O36_RS03250	COG4372	Transposase
D1O36_RS03255	COG0006	proline dipeptidase activity
D1O36_RS03260	COG1609	Transcriptional regulator
D1O36_RS03295	COG1368	sulfuric ester hydrolase activity
D1O36_RS03300	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D1O36_RS03350	COG0077	Prephenate dehydratase
D1O36_RS03420	COG3328	transposase activity
D1O36_RS03485	COG1518	maintenance of DNA repeat elements
D1O36_RS03490	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
D1O36_RS03500	COG4372	Transposase
D1O36_RS03520	COG3689	TIGRFAM TIGR03943 family protein
D1O36_RS03525	COG0701	Predicted permease
D1O36_RS03530	COG2183	response to ionizing radiation
D1O36_RS03575	COG0826	peptidase U32
D1O36_RS03585	COG1268	BioY protein
D1O36_RS03595	COG4443	Transcriptional Coactivator p15 (PC4)
D1O36_RS03600	COG1914	H( )-stimulated, divalent metal cation uptake system
D1O36_RS03660	COG0406	alpha-ribazole phosphatase activity
D1O36_RS03665	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D1O36_RS03710	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D1O36_RS03735	COG3620	sequence-specific DNA binding
D1O36_RS03760	COG1704	LemA family
D1O36_RS03765	COG0501	Belongs to the peptidase M48B family
D1O36_RS03790	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D1O36_RS03800	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D1O36_RS03805	COG0783	Belongs to the Dps family
D1O36_RS03810	COG0735	belongs to the Fur family
D1O36_RS03815	COG4483	Protein conserved in bacteria
D1O36_RS03820	COG1940	carbohydrate kinase activity
D1O36_RS03825	COG1217	gtp-binding protein TYPA
D1O36_RS03860	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D1O36_RS03885	COG3599	regulation of cell shape
D1O36_RS03920	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D1O36_RS03930	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D1O36_RS03935	COG1435	thymidine kinase activity
D1O36_RS03945	COG2890	protein-(glutamine-N5) methyltransferase activity
D1O36_RS03955	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1O36_RS03975	COG1132	(ABC) transporter
D1O36_RS03980	COG3328	transposase activity
D1O36_RS03995	COG1696	Membrane protein involved in D-alanine export
D1O36_RS04005	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
D1O36_RS04030	COG4372	Transposase
D1O36_RS04040	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D1O36_RS04045	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D1O36_RS04080	COG4372	Transposase
D1O36_RS04085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1O36_RS04090	COG4684	Psort location CytoplasmicMembrane, score
D1O36_RS04095	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D1O36_RS04140	COG2813	Specifically methylates the guanine in position
D1O36_RS04150	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
D1O36_RS04165	COG0295	cytidine deaminase activity
D1O36_RS04170	COG1744	ABC transporter substrate-binding protein PnrA-like
D1O36_RS04175	COG3845	ABC transporter
D1O36_RS04180	COG4603	Belongs to the binding-protein-dependent transport system permease family
D1O36_RS04185	COG1079	Belongs to the binding-protein-dependent transport system permease family
D1O36_RS04195	COG1199	ATP-dependent helicase activity
D1O36_RS04195	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D1O36_RS04205	COG0436	Aminotransferase
D1O36_RS04225	COG0251	oxidation-reduction process
D1O36_RS04235	COG0720	synthase
D1O36_RS04295	COG1278	Cold shock
D1O36_RS04310	COG2217	Heavy metal translocating P-type atpase
D1O36_RS04330	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D1O36_RS04335	COG0626	cystathionine gamma-synthase activity
D1O36_RS04360	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
D1O36_RS04370	COG3328	transposase activity
D1O36_RS04375	COG4975	Glucose uptake
D1O36_RS04400	COG0803	Belongs to the bacterial solute-binding protein 9 family
D1O36_RS04400	COG3443	Belongs to the bacterial solute-binding protein 9 family
D1O36_RS04420	COG1705	Flagellar rod assembly protein muramidase FlgJ
D1O36_RS04420	COG3942	CHAP domain
D1O36_RS04435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1O36_RS04440	COG2824	Alkylphosphonate utilization operon protein PhnA
D1O36_RS04445	COG0765	amino acid transport
D1O36_RS04450	COG1126	abc transporter atp-binding protein
D1O36_RS04455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1O36_RS04465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D1O36_RS04480	COG1064	alcohol dehydrogenase
D1O36_RS04485	COG1064	alcohol dehydrogenase
D1O36_RS04495	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D1O36_RS04495	COG0519	Catalyzes the synthesis of GMP from XMP
D1O36_RS04500	COG2188	Transcriptional regulator
D1O36_RS04510	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D1O36_RS04520	COG1827	regulation of RNA biosynthetic process
D1O36_RS04530	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D1O36_RS04540	COG1940	carbohydrate kinase activity
D1O36_RS04545	COG0758	DNA mediated transformation
D1O36_RS04550	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D1O36_RS04555	COG3328	transposase activity
D1O36_RS04600	COG0481	GTPase activity
D1O36_RS04625	COG1396	sequence-specific DNA binding
D1O36_RS04635	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D1O36_RS04640	COG0010	Belongs to the arginase family
D1O36_RS04665	COG4372	Transposase
D1O36_RS04670	COG0028	Belongs to the TPP enzyme family
D1O36_RS04675	COG3527	Alpha-acetolactate decarboxylase
D1O36_RS04705	COG1230	cation diffusion facilitator family transporter
D1O36_RS04715	COG1063	alcohol dehydrogenase
D1O36_RS04720	COG3328	transposase activity
D1O36_RS04745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1O36_RS04780	COG3328	transposase activity
D1O36_RS04785	COG1293	RNA-binding protein homologous to eukaryotic snRNP
D1O36_RS04795	COG0047	phosphoribosylformylglycinamidine synthase activity
D1O36_RS04810	COG0167	dihydroorotate dehydrogenase activity
D1O36_RS04820	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
D1O36_RS04840	COG1337	RAMP superfamily
D1O36_RS04845	COG1567	CRISPR-associated RAMP protein, Csm4 family
D1O36_RS04865	COG0284	orotidine-5'-phosphate decarboxylase activity
D1O36_RS04880	COG3104	oligopeptide transport
D1O36_RS04885	COG3328	transposase activity
D1O36_RS04940	COG1115	amino acid carrier protein
D1O36_RS04950	COG2873	o-acetylhomoserine
D1O36_RS04985	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D1O36_RS04990	COG0196	riboflavin kinase activity
D1O36_RS04995	COG1393	Belongs to the ArsC family
D1O36_RS05005	COG0483	inositol monophosphate 1-phosphatase activity
D1O36_RS05020	COG0573	inorganic phosphate transmembrane transporter activity
D1O36_RS05025	COG0581	inorganic phosphate transmembrane transporter activity
D1O36_RS05040	COG0704	Plays a role in the regulation of phosphate uptake
D1O36_RS05055	COG0095	Lipoate-protein ligase
D1O36_RS05070	COG0058	SHG alpha-glucan phosphorylase activity
D1O36_RS05075	COG1640	4-alpha-glucanotransferase
D1O36_RS05090	COG1175	transmembrane transport
D1O36_RS05105	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1O36_RS05110	COG0805	protein transport
D1O36_RS05115	COG0672	)-iron permease
D1O36_RS05120	COG2837	iron assimilation
D1O36_RS05125	COG2822	iron ion transport
D1O36_RS05130	COG4607	ABC-type enterochelin transport system periplasmic component
D1O36_RS05135	COG4604	ABC transporter, ATP-binding protein
D1O36_RS05140	COG4605	iron ion homeostasis
D1O36_RS05145	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1O36_RS05170	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1O36_RS05175	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1O36_RS05175	COG0022	dehydrogenase e1 component
D1O36_RS05180	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D1O36_RS05200	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D1O36_RS05210	COG4667	esterase of the alpha-beta hydrolase superfamily
D1O36_RS05255	COG0628	permease
D1O36_RS05280	COG1216	Glycosyl transferase, family 2
D1O36_RS05280	COG1442	glycosyl transferase family 8
D1O36_RS05290	COG2244	polysaccharide biosynthetic process
D1O36_RS05325	COG1316	TRANSCRIPTIONal
D1O36_RS05390	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D1O36_RS05410	COG1316	TRANSCRIPTIONal
D1O36_RS05445	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D1O36_RS05455	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D1O36_RS05475	COG1573	uracil-dna glycosylase
D1O36_RS05540	COG0681	Belongs to the peptidase S26 family
D1O36_RS05550	COG0628	permease
D1O36_RS05555	COG1051	belongs to the nudix hydrolase family
D1O36_RS05560	COG2177	Part of the ABC transporter FtsEX involved in
D1O36_RS05565	COG2884	Cell division ATP-binding protein ftsE
D1O36_RS05575	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D1O36_RS05610	COG2348	transferase activity, transferring amino-acyl groups
D1O36_RS05620	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D1O36_RS05625	COG5002	protein histidine kinase activity
D1O36_RS05630	COG0745	RESPONSE REGULATOR receiver
D1O36_RS05635	COG1126	abc transporter atp-binding protein
D1O36_RS05640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1O36_RS05645	COG0765	amino acid transport
D1O36_RS05650	COG0765	amino acid transport
D1O36_RS05675	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D1O36_RS05685	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D1O36_RS05690	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
D1O36_RS05690	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
D1O36_RS05700	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D1O36_RS05705	COG1956	GAF domain-containing protein
D1O36_RS05730	COG0335	large ribosomal subunit rRNA binding
D1O36_RS05735	COG0038	chloride channel
D1O36_RS05745	COG0038	chloride channel
D1O36_RS05750	COG0716	FMN binding
D1O36_RS05820	COG0469	pyruvate kinase activity
D1O36_RS05870	COG0167	dihydroorotate dehydrogenase activity
D1O36_RS05880	COG0776	regulation of translation
D1O36_RS05890	COG2755	lipolytic protein G-D-S-L family
D1O36_RS05895	COG1307	EDD domain protein, DegV family
D1O36_RS05900	COG0497	DNA recombination
D1O36_RS05905	COG1438	arginine binding
D1O36_RS05910	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
D1O36_RS05935	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D1O36_RS05955	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D1O36_RS05955	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D1O36_RS05960	COG0300	oxidoreductase activity
D1O36_RS05980	COG0772	Belongs to the SEDS family
D1O36_RS05995	COG0107	imidazoleglycerol-phosphate synthase activity
D1O36_RS06005	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D1O36_RS06015	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D1O36_RS06065	COG0647	UMP catabolic process
D1O36_RS06075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D1O36_RS06085	COG3328	transposase activity
D1O36_RS06105	COG1088	dTDP-glucose 4,6-dehydratase activity
D1O36_RS06115	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
D1O36_RS06120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1O36_RS06160	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D1O36_RS06165	COG3442	glutamine amidotransferase
D1O36_RS06170	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
D1O36_RS06170	COG0392	lysyltransferase activity
D1O36_RS06185	COG0488	(ABC) transporter
D1O36_RS06195	COG0513	Belongs to the DEAD box helicase family
D1O36_RS06200	COG4372	Transposase
D1O36_RS06245	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D1O36_RS06250	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D1O36_RS06255	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1O36_RS06260	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1O36_RS06290	COG3764	Sortase (surface protein transpeptidase)
D1O36_RS06310	COG0488	(ABC) transporter
D1O36_RS06335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1O36_RS06340	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D1O36_RS06340	COG1328	CTP reductase activity
D1O36_RS06390	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D1O36_RS06410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D1O36_RS06415	COG0322	excinuclease ABC activity
D1O36_RS06420	COG1011	Hydrolase
D1O36_RS06425	COG1268	BioY protein
D1O36_RS06435	COG1125	glycine betaine transport
D1O36_RS06435	COG0517	IMP dehydrogenase activity
D1O36_RS06450	COG2986	histidine ammonia-lyase
D1O36_RS06465	COG3328	transposase activity
D1O36_RS06470	COG1760	l-serine dehydratase
D1O36_RS06505	COG1131	(ABC) transporter
D1O36_RS06515	COG2197	response regulator
D1O36_RS06520	COG4585	Histidine kinase
D1O36_RS06530	COG1131	(ABC) transporter
D1O36_RS06545	COG0385	Bile acid
D1O36_RS06580	COG0577	efflux transmembrane transporter activity
D1O36_RS06585	COG1136	(ABC) transporter
D1O36_RS06590	COG5002	protein histidine kinase activity
D1O36_RS06590	COG0784	Response regulator, receiver
D1O36_RS06590	COG2198	Histidine kinase
D1O36_RS06595	COG0745	RESPONSE REGULATOR receiver
D1O36_RS06645	COG0531	amino acid
D1O36_RS06670	COG1126	abc transporter atp-binding protein
D1O36_RS06675	COG0765	amino acid transport
D1O36_RS06680	COG0765	amino acid transport
D1O36_RS06685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1O36_RS06695	COG3328	transposase activity
D1O36_RS06700	COG0386	Belongs to the glutathione peroxidase family
D1O36_RS06735	COG2514	catechol 2,3-dioxygenase activity
D1O36_RS06740	COG1959	2 iron, 2 sulfur cluster binding
D1O36_RS06750	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D1O36_RS06750	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D1O36_RS06755	COG0778	Nitroreductase
D1O36_RS06765	COG0656	L-ascorbic acid biosynthetic process
D1O36_RS06770	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D1O36_RS06810	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D1O36_RS06845	COG1442	glycosyl transferase family 8
D1O36_RS06845	COG1216	Glycosyl transferase, family 2
D1O36_RS06850	COG0577	efflux transmembrane transporter activity
D1O36_RS06875	COG0419	ATPase involved in DNA repair
D1O36_RS06880	COG0420	3'-5' exonuclease activity
D1O36_RS06890	COG3250	beta-galactosidase activity
D1O36_RS06900	COG2017	converts alpha-aldose to the beta-anomer
D1O36_RS06905	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D1O36_RS06910	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
D1O36_RS06915	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D1O36_RS06920	COG3328	transposase activity
D1O36_RS06925	COG1609	Transcriptional regulator
D1O36_RS06945	COG0488	(ABC) transporter
D1O36_RS07000	COG2197	response regulator
D1O36_RS07005	COG4585	Histidine kinase
D1O36_RS07020	COG0515	serine threonine protein kinase
D1O36_RS07020	COG2815	serine threonine protein kinase
D1O36_RS07040	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D1O36_RS07055	COG0552	protein localization to endoplasmic reticulum
D1O36_RS07060	COG0561	phosphatase activity
D1O36_RS07065	COG0561	phosphatase activity
D1O36_RS07070	COG1725	Transcriptional regulator
D1O36_RS07075	COG1131	(ABC) transporter
D1O36_RS07085	COG4608	Belongs to the ABC transporter superfamily
D1O36_RS07090	COG0444	Belongs to the ABC transporter superfamily
D1O36_RS07095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1O36_RS07100	COG0601	transmembrane transport
D1O36_RS07105	COG4166	transmembrane transport
D1O36_RS07115	COG4166	transmembrane transport
D1O36_RS07125	COG4608	Belongs to the ABC transporter superfamily
D1O36_RS07130	COG4608	Belongs to the ABC transporter superfamily
D1O36_RS07140	COG2223	nitrite transmembrane transporter activity
D1O36_RS07150	COG0280	phosphate acetyltransferase
D1O36_RS07155	COG0564	pseudouridine synthase activity
D1O36_RS07165	COG2357	RelA SpoT domain protein
D1O36_RS07195	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D1O36_RS07200	COG2003	Belongs to the UPF0758 family
D1O36_RS07225	COG1215	transferase activity, transferring glycosyl groups
D1O36_RS07240	COG1442	glycosyl transferase family 8
D1O36_RS07240	COG1216	Glycosyl transferase, family 2
D1O36_RS07260	COG1091	dTDP-4-dehydrorhamnose reductase activity
D1O36_RS07270	COG0463	Glycosyl transferase, family 2
D1O36_RS07275	COG2151	metal-sulfur cluster biosynthetic enzyme
D1O36_RS07280	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D1O36_RS07285	COG0358	DNA primase activity
D1O36_RS07300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1O36_RS07305	COG0436	Aminotransferase
D1O36_RS07310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1O36_RS07315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1O36_RS07320	COG1051	belongs to the nudix hydrolase family
D1O36_RS07340	COG0765	amino acid transport
D1O36_RS07345	COG1126	abc transporter atp-binding protein
D1O36_RS07405	COG4372	Transposase
D1O36_RS07425	COG0560	Phosphoserine phosphatase
D1O36_RS07435	COG0187	DNA topoisomerase II activity
D1O36_RS07445	COG1346	cytolysis
D1O36_RS07450	COG1380	Effector of murein hydrolase LrgA
D1O36_RS07460	COG1393	Belongs to the ArsC family
D1O36_RS07470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D1O36_RS07505	COG1177	transmembrane transport
D1O36_RS07510	COG1176	ABC-type spermidine putrescine transport system, permease component I
D1O36_RS07550	COG0531	amino acid
D1O36_RS07555	COG0285	dihydrofolate synthase activity
D1O36_RS07560	COG1837	Belongs to the UPF0109 family
D1O36_RS07570	COG0500	methyltransferase
D1O36_RS07570	COG3615	Tellurite resistance protein tehB
D1O36_RS07580	COG0708	Exodeoxyribonuclease III
D1O36_RS07595	COG1597	lipid kinase activity
D1O36_RS07605	COG4708	membrane
D1O36_RS07615	COG0024	Methionine aminopeptidase
D1O36_RS07620	COG4109	DRTGG domain
D1O36_RS07630	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D1O36_RS07635	COG0658	competence protein
D1O36_RS07635	COG2333	competence protein COMEC
D1O36_RS07640	COG1555	photosystem II stabilization
D1O36_RS07640	COG1596	polysaccharide export
D1O36_RS07645	COG0204	Acyl-transferase
D1O36_RS07655	COG0726	polysaccharide deacetylase
D1O36_RS07660	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D1O36_RS07670	COG0513	Belongs to the DEAD box helicase family
D1O36_RS07700	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D1O36_RS07715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1O36_RS07720	COG1126	abc transporter atp-binding protein
D1O36_RS07725	COG0765	amino acid transport
D1O36_RS07730	COG0765	amino acid transport
D1O36_RS07735	COG1181	Belongs to the D-alanine--D-alanine ligase family
D1O36_RS07745	COG2217	Heavy metal translocating P-type atpase
D1O36_RS07755	COG0159	tryptophan synthase activity
D1O36_RS07765	COG0135	phosphoribosylanthranilate isomerase activity
D1O36_RS07780	COG0512	Glutamine amidotransferase of anthranilate synthase
D1O36_RS07785	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D1O36_RS07790	COG1605	Chorismate mutase
D1O36_RS07790	COG0287	Prephenate dehydrogenase
D1O36_RS07800	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D1O36_RS07855	COG2151	metal-sulfur cluster biosynthetic enzyme
D1O36_RS07865	COG2081	HI0933 family
D1O36_RS07890	COG1131	(ABC) transporter
D1O36_RS07895	COG0537	adenosine 5'-monophosphoramidase activity
D1O36_RS07925	COG2226	methyltransferase
D1O36_RS07935	COG0799	negative regulation of ribosome biogenesis
D1O36_RS07940	COG1713	HD superfamily hydrolase involved in NAD metabolism
D1O36_RS07945	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D1O36_RS07950	COG1534	Rna-binding protein
D1O36_RS07955	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D1O36_RS07960	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
D1O36_RS08015	COG1335	isochorismatase
D1O36_RS08025	COG0436	Aminotransferase
D1O36_RS08030	COG0589	response to stress
D1O36_RS08045	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D1O36_RS08050	COG3328	transposase activity
D1O36_RS08060	COG3328	transposase activity
D1O36_RS08065	COG1253	flavin adenine dinucleotide binding
D1O36_RS08070	COG1119	ATPase activity
D1O36_RS08075	COG0025	NhaP-type Na H and K H
D1O36_RS08085	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D1O36_RS08090	COG1242	4 iron, 4 sulfur cluster binding
D1O36_RS08095	COG3480	Lon protease (S16) C-terminal proteolytic domain
D1O36_RS08100	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D1O36_RS08105	COG0742	ribosomal rna small subunit methyltransferase
D1O36_RS08110	COG0492	ferredoxin-NADP+ reductase activity
D1O36_RS08120	COG1126	abc transporter atp-binding protein
D1O36_RS08130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1O36_RS08145	COG1882	Formate acetyltransferase
D1O36_RS08175	COG0390	transport system, permease component
D1O36_RS08180	COG4619	ABC transporter
D1O36_RS08190	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1O36_RS08205	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D1O36_RS08275	COG3290	protein histidine kinase activity
D1O36_RS08285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1O36_RS08330	COG4470	Protein conserved in bacteria
D1O36_RS08335	COG0737	Belongs to the 5'-nucleotidase family
D1O36_RS08345	COG0513	Belongs to the DEAD box helicase family
D1O36_RS08355	COG0768	penicillin binding
D1O36_RS08385	COG3152	Membrane
D1O36_RS08395	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D1O36_RS08420	COG1074	ATP-dependent DNA helicase activity
D1O36_RS08455	COG0561	phosphatase activity
D1O36_RS08460	COG0252	asparaginase activity
D1O36_RS08465	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D1O36_RS08480	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D1O36_RS08485	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D1O36_RS08490	COG0653	protein targeting
D1O36_RS08500	COG1482	cell wall glycoprotein biosynthetic process
D1O36_RS08505	COG1940	carbohydrate kinase activity
D1O36_RS08510	COG2190	(PTS) system
D1O36_RS08510	COG1263	PTS System
D1O36_RS08510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D1O36_RS08515	COG1621	beta-fructofuranosidase activity
D1O36_RS08520	COG1609	Transcriptional regulator
D1O36_RS08535	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D1O36_RS08540	COG2131	deaminase
D1O36_RS08545	COG0006	proline dipeptidase activity
D1O36_RS08635	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1O36_RS08635	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1O36_RS08640	COG1193	negative regulation of DNA recombination
D1O36_RS08660	COG0681	Belongs to the peptidase S26 family
D1O36_RS08665	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D1O36_RS08675	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D1O36_RS08685	COG0456	acetyltransferase
D1O36_RS08690	COG1214	PFAM Peptidase M22, glycoprotease
D1O36_RS08710	COG0174	glutamine synthetase
D1O36_RS08715	COG0789	Transcriptional regulator
D1O36_RS08765	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D1O36_RS08810	COG0084	hydrolase, TatD family'
D1O36_RS08815	COG1832	CoA-binding protein
D1O36_RS08820	COG3118	belongs to the thioredoxin family
D1O36_RS08885	COG0706	membrane insertase activity
D1O36_RS08945	COG0756	dUTP diphosphatase activity
D1O36_RS08975	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D1O36_RS08980	COG0705	Rhomboid family
D1O36_RS08980	COG0457	Tetratricopeptide repeat
D1O36_RS08985	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D1O36_RS09005	COG2226	methyltransferase
D1O36_RS09035	COG0425	Belongs to the sulfur carrier protein TusA family
D1O36_RS09040	COG2391	methyltransferase activity
D1O36_RS09045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1O36_RS09050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1O36_RS09060	COG1363	Peptidase, m42
D1O36_RS09065	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D1O36_RS09070	COG1266	CAAX protease self-immunity
D1O36_RS09125	COG1459	type II secretion system
D1O36_RS09135	COG4372	Transposase
D1O36_RS09190	COG0440	acetolactate synthase activity
D1O36_RS09195	COG0028	Belongs to the TPP enzyme family
D1O36_RS09200	COG0129	dihydroxy-acid dehydratase activity
D1O36_RS09205	COG1461	Dihydroxyacetone kinase
D1O36_RS09215	COG0534	Mate efflux family protein
D1O36_RS09230	COG1012	belongs to the aldehyde dehydrogenase family
D1O36_RS09230	COG1454	alcohol dehydrogenase
D1O36_RS09235	COG1454	alcohol dehydrogenase
D1O36_RS09235	COG1012	belongs to the aldehyde dehydrogenase family
D1O36_RS09245	COG1454	alcohol dehydrogenase
D1O36_RS09245	COG1012	belongs to the aldehyde dehydrogenase family
D1O36_RS09250	COG3590	peptidase
D1O36_RS09265	COG1609	Transcriptional regulator
D1O36_RS09270	COG2188	Transcriptional regulator
D1O36_RS09275	COG4475	Protein of unknown function (DUF436)
D1O36_RS09345	COG4372	Transposase
D1O36_RS09425	COG3328	transposase activity
D1O36_RS09430	COG0582	viral genome integration into host DNA
D1O36_RS09435	COG0191	fructose-bisphosphate aldolase activity
D1O36_RS09500	COG0201	protein transport
D1O36_RS09640	COG1396	sequence-specific DNA binding
D1O36_RS09645	COG1396	sequence-specific DNA binding
D1O36_RS09655	COG1132	(ABC) transporter
D1O36_RS09690	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D1O36_RS09720	COG1328	CTP reductase activity
D1O36_RS09735	COG0602	queuosine metabolic process
D1O36_RS09745	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D1O36_RS09780	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D1O36_RS09785	COG3328	transposase activity
D1O36_RS09810	COG2261	transglycosylase associated protein
D1O36_RS09820	COG3328	transposase activity
D1O36_RS09835	COG3237	CsbD-like
D1O36_RS09860	COG1511	domain protein
D1O36_RS09860	COG1511	domain protein
D1O36_RS09870	COG3759	membrane
D1O36_RS09890	COG0305	Participates in initiation and elongation during chromosome replication
D1O36_RS09920	COG0741	lytic transglycosylase activity
D1O36_RS09925	COG3584	3D domain protein
D1O36_RS09925	COG1388	LysM domain
D1O36_RS09930	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D1O36_RS09945	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D1O36_RS09955	COG0612	Peptidase, M16
D1O36_RS09960	COG0612	Peptidase, M16
D1O36_RS09985	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D1O36_RS09990	COG0488	(ABC) transporter
D1O36_RS10025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1O36_RS10030	COG1475	DNA binding