locus-tag	class	description
GFB63_RS00015	COG0038	chloride channel
GFB63_RS00020	COG0716	FMN binding
GFB63_RS00080	COG0469	pyruvate kinase activity
GFB63_RS00130	COG0167	dihydroorotate dehydrogenase activity
GFB63_RS00140	COG0776	regulation of translation
GFB63_RS00155	COG1307	EDD domain protein, DegV family
GFB63_RS00160	COG0497	DNA recombination
GFB63_RS00165	COG1438	arginine binding
GFB63_RS00170	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GFB63_RS00195	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GFB63_RS00215	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GFB63_RS00215	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GFB63_RS00220	COG0300	oxidoreductase activity
GFB63_RS00235	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GFB63_RS00240	COG0772	Belongs to the SEDS family
GFB63_RS00255	COG0107	imidazoleglycerol-phosphate synthase activity
GFB63_RS00265	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GFB63_RS00275	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GFB63_RS00320	COG0647	UMP catabolic process
GFB63_RS00330	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GFB63_RS00345	COG3328	transposase activity
GFB63_RS00365	COG1088	dTDP-glucose 4,6-dehydratase activity
GFB63_RS00375	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GFB63_RS00380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GFB63_RS00395	COG2384	SAM-dependent methyltransferase
GFB63_RS00420	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GFB63_RS00425	COG3442	glutamine amidotransferase
GFB63_RS00440	COG0488	(ABC) transporter
GFB63_RS00450	COG0513	Belongs to the DEAD box helicase family
GFB63_RS00475	COG0372	Belongs to the citrate synthase family
GFB63_RS00480	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GFB63_RS00485	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GFB63_RS00490	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GFB63_RS00495	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GFB63_RS00525	COG3764	Sortase (surface protein transpeptidase)
GFB63_RS00545	COG0488	(ABC) transporter
GFB63_RS00555	COG3328	transposase activity
GFB63_RS00575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GFB63_RS00580	COG1328	CTP reductase activity
GFB63_RS00580	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GFB63_RS00605	COG1196	nuclear chromosome segregation
GFB63_RS00620	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GFB63_RS00640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GFB63_RS00655	COG1760	l-serine dehydratase
GFB63_RS00660	COG1760	l-serine dehydratase
GFB63_RS00685	COG2197	response regulator
GFB63_RS00690	COG4585	Histidine kinase
GFB63_RS00700	COG1131	(ABC) transporter
GFB63_RS00715	COG0385	Bile acid
GFB63_RS00750	COG0577	efflux transmembrane transporter activity
GFB63_RS00755	COG1136	(ABC) transporter
GFB63_RS00760	COG0784	Response regulator, receiver
GFB63_RS00760	COG2198	Histidine kinase
GFB63_RS00760	COG5002	protein histidine kinase activity
GFB63_RS00765	COG0745	RESPONSE REGULATOR receiver
GFB63_RS00780	COG0534	Mate efflux family protein
GFB63_RS00785	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GFB63_RS00785	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GFB63_RS00815	COG0531	amino acid
GFB63_RS00835	COG1126	abc transporter atp-binding protein
GFB63_RS00840	COG0765	amino acid transport
GFB63_RS00845	COG0765	amino acid transport
GFB63_RS00850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFB63_RS00860	COG0386	Belongs to the glutathione peroxidase family
GFB63_RS00895	COG2514	catechol 2,3-dioxygenase activity
GFB63_RS00900	COG1959	2 iron, 2 sulfur cluster binding
GFB63_RS00910	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GFB63_RS00910	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GFB63_RS00915	COG0778	Nitroreductase
GFB63_RS00925	COG0656	L-ascorbic acid biosynthetic process
GFB63_RS00930	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GFB63_RS00970	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GFB63_RS00990	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GFB63_RS01005	COG1216	Glycosyl transferase, family 2
GFB63_RS01005	COG1442	glycosyl transferase family 8
GFB63_RS01055	COG0419	ATPase involved in DNA repair
GFB63_RS01060	COG0420	3'-5' exonuclease activity
GFB63_RS01070	COG3250	beta-galactosidase activity
GFB63_RS01075	COG2211	Major facilitator Superfamily
GFB63_RS01075	COG2190	(PTS) system
GFB63_RS01080	COG2017	converts alpha-aldose to the beta-anomer
GFB63_RS01085	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GFB63_RS01125	COG0488	(ABC) transporter
GFB63_RS01170	COG3328	transposase activity
GFB63_RS01235	COG2197	response regulator
GFB63_RS01240	COG4585	Histidine kinase
GFB63_RS01255	COG0515	serine threonine protein kinase
GFB63_RS01255	COG2815	serine threonine protein kinase
GFB63_RS01265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GFB63_RS01265	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GFB63_RS01275	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GFB63_RS01290	COG0552	protein localization to endoplasmic reticulum
GFB63_RS01295	COG0561	phosphatase activity
GFB63_RS01300	COG0561	phosphatase activity
GFB63_RS01305	COG1725	Transcriptional regulator
GFB63_RS01310	COG1131	(ABC) transporter
GFB63_RS01320	COG4608	Belongs to the ABC transporter superfamily
GFB63_RS01325	COG0444	Belongs to the ABC transporter superfamily
GFB63_RS01330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GFB63_RS01335	COG0601	transmembrane transport
GFB63_RS01340	COG4166	transmembrane transport
GFB63_RS01350	COG4608	Belongs to the ABC transporter superfamily
GFB63_RS01355	COG4608	Belongs to the ABC transporter superfamily
GFB63_RS01360	COG0084	hydrolase, TatD family'
GFB63_RS01365	COG2223	nitrite transmembrane transporter activity
GFB63_RS01375	COG0280	phosphate acetyltransferase
GFB63_RS01380	COG0564	pseudouridine synthase activity
GFB63_RS01390	COG2357	RelA SpoT domain protein
GFB63_RS01405	COG1104	cysteine desulfurase activity
GFB63_RS01420	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GFB63_RS01425	COG2003	Belongs to the UPF0758 family
GFB63_RS01450	COG1215	transferase activity, transferring glycosyl groups
GFB63_RS01465	COG1442	glycosyl transferase family 8
GFB63_RS01465	COG1216	Glycosyl transferase, family 2
GFB63_RS01480	COG0463	Glycosyl transferase, family 2
GFB63_RS01485	COG1091	dTDP-4-dehydrorhamnose reductase activity
GFB63_RS01495	COG0463	Glycosyl transferase, family 2
GFB63_RS01500	COG2151	metal-sulfur cluster biosynthetic enzyme
GFB63_RS01505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GFB63_RS01510	COG0358	DNA primase activity
GFB63_RS01515	COG1970	mechanosensitive ion channel activity
GFB63_RS01525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFB63_RS01530	COG0436	Aminotransferase
GFB63_RS01535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFB63_RS01540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFB63_RS01545	COG1051	belongs to the nudix hydrolase family
GFB63_RS01565	COG0765	amino acid transport
GFB63_RS01570	COG1126	abc transporter atp-binding protein
GFB63_RS01590	COG1187	pseudouridine synthase activity
GFB63_RS01630	COG0560	Phosphoserine phosphatase
GFB63_RS01640	COG0187	DNA topoisomerase II activity
GFB63_RS01650	COG1346	cytolysis
GFB63_RS01655	COG1380	Effector of murein hydrolase LrgA
GFB63_RS01665	COG1393	Belongs to the ArsC family
GFB63_RS01675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GFB63_RS01710	COG1177	transmembrane transport
GFB63_RS01715	COG1176	ABC-type spermidine putrescine transport system, permease component I
GFB63_RS01755	COG0531	amino acid
GFB63_RS01760	COG0285	dihydrofolate synthase activity
GFB63_RS01765	COG1837	Belongs to the UPF0109 family
GFB63_RS01775	COG0500	methyltransferase
GFB63_RS01775	COG3615	Tellurite resistance protein tehB
GFB63_RS01785	COG0708	Exodeoxyribonuclease III
GFB63_RS01800	COG1597	lipid kinase activity
GFB63_RS01810	COG4708	membrane
GFB63_RS01820	COG0024	Methionine aminopeptidase
GFB63_RS01825	COG4109	DRTGG domain
GFB63_RS01840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GFB63_RS01845	COG2333	competence protein COMEC
GFB63_RS01845	COG0658	competence protein
GFB63_RS01850	COG1596	polysaccharide export
GFB63_RS01850	COG1555	photosystem II stabilization
GFB63_RS01855	COG0204	Acyl-transferase
GFB63_RS01860	COG0726	polysaccharide deacetylase
GFB63_RS01865	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GFB63_RS01875	COG0513	Belongs to the DEAD box helicase family
GFB63_RS01910	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GFB63_RS01925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFB63_RS01930	COG1126	abc transporter atp-binding protein
GFB63_RS01935	COG0765	amino acid transport
GFB63_RS01940	COG0765	amino acid transport
GFB63_RS01955	COG2217	Heavy metal translocating P-type atpase
GFB63_RS01965	COG0159	tryptophan synthase activity
GFB63_RS01975	COG0135	phosphoribosylanthranilate isomerase activity
GFB63_RS01990	COG0512	Glutamine amidotransferase of anthranilate synthase
GFB63_RS01995	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GFB63_RS02000	COG1605	Chorismate mutase
GFB63_RS02000	COG0287	Prephenate dehydrogenase
GFB63_RS02010	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GFB63_RS02045	COG2151	metal-sulfur cluster biosynthetic enzyme
GFB63_RS02055	COG2081	HI0933 family
GFB63_RS02080	COG1131	(ABC) transporter
GFB63_RS02085	COG0537	adenosine 5'-monophosphoramidase activity
GFB63_RS02110	COG3328	transposase activity
GFB63_RS02125	COG2226	methyltransferase
GFB63_RS02130	COG0799	negative regulation of ribosome biogenesis
GFB63_RS02135	COG1713	HD superfamily hydrolase involved in NAD metabolism
GFB63_RS02140	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GFB63_RS02145	COG1534	Rna-binding protein
GFB63_RS02150	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GFB63_RS02155	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GFB63_RS02195	COG2723	6-phospho-beta-galactosidase activity
GFB63_RS02210	COG1335	isochorismatase
GFB63_RS02220	COG0436	Aminotransferase
GFB63_RS02225	COG0589	response to stress
GFB63_RS02240	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GFB63_RS02245	COG1253	flavin adenine dinucleotide binding
GFB63_RS02250	COG1119	ATPase activity
GFB63_RS02255	COG0025	NhaP-type Na H and K H
GFB63_RS02265	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GFB63_RS02270	COG1242	4 iron, 4 sulfur cluster binding
GFB63_RS02275	COG3480	Lon protease (S16) C-terminal proteolytic domain
GFB63_RS02280	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GFB63_RS02285	COG0742	ribosomal rna small subunit methyltransferase
GFB63_RS02290	COG0492	ferredoxin-NADP+ reductase activity
GFB63_RS02300	COG1126	abc transporter atp-binding protein
GFB63_RS02310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFB63_RS02325	COG1882	Formate acetyltransferase
GFB63_RS02360	COG0390	transport system, permease component
GFB63_RS02365	COG4619	ABC transporter
GFB63_RS02370	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GFB63_RS02400	COG0640	Transcriptional regulator
GFB63_RS02405	COG0697	spore germination
GFB63_RS02420	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GFB63_RS02420	COG0473	3-isopropylmalate dehydrogenase activity
GFB63_RS02425	COG0473	3-isopropylmalate dehydrogenase activity
GFB63_RS02425	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GFB63_RS02445	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GFB63_RS02545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GFB63_RS02550	COG2274	protein secretion by the type I secretion system
GFB63_RS02555	COG1132	(ABC) transporter
GFB63_RS02560	COG1132	(ABC) transporter
GFB63_RS02580	COG4470	Protein conserved in bacteria
GFB63_RS02585	COG0737	Belongs to the 5'-nucleotidase family
GFB63_RS02595	COG0513	Belongs to the DEAD box helicase family
GFB63_RS02605	COG0768	penicillin binding
GFB63_RS02630	COG3152	Membrane
GFB63_RS02640	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GFB63_RS02645	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GFB63_RS02655	COG4152	abc transporter atp-binding protein
GFB63_RS02660	COG1811	Na channel or pump
GFB63_RS02670	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GFB63_RS02705	COG0561	phosphatase activity
GFB63_RS02710	COG0252	asparaginase activity
GFB63_RS02715	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GFB63_RS02730	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GFB63_RS02735	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GFB63_RS02740	COG0653	protein targeting
GFB63_RS02750	COG1482	cell wall glycoprotein biosynthetic process
GFB63_RS02755	COG1940	carbohydrate kinase activity
GFB63_RS02760	COG1263	PTS System
GFB63_RS02760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFB63_RS02760	COG2190	(PTS) system
GFB63_RS02765	COG1621	beta-fructofuranosidase activity
GFB63_RS02770	COG1609	Transcriptional regulator
GFB63_RS02785	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GFB63_RS02790	COG2131	deaminase
GFB63_RS02795	COG0006	proline dipeptidase activity
GFB63_RS02810	COG1131	(ABC) transporter
GFB63_RS02900	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GFB63_RS02900	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GFB63_RS02925	COG0681	Belongs to the peptidase S26 family
GFB63_RS02930	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GFB63_RS02940	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GFB63_RS02950	COG0456	acetyltransferase
GFB63_RS02955	COG1214	PFAM Peptidase M22, glycoprotease
GFB63_RS02975	COG0174	glutamine synthetase
GFB63_RS02980	COG0789	Transcriptional regulator
GFB63_RS03030	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GFB63_RS03075	COG0084	hydrolase, TatD family'
GFB63_RS03080	COG1832	CoA-binding protein
GFB63_RS03085	COG3118	belongs to the thioredoxin family
GFB63_RS03160	COG0706	membrane insertase activity
GFB63_RS03225	COG0756	dUTP diphosphatase activity
GFB63_RS03235	COG0431	NADPH-dependent FMN reductase
GFB63_RS03235	COG1053	succinate dehydrogenase
GFB63_RS03235	COG3976	FMN-binding domain protein
GFB63_RS03255	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GFB63_RS03260	COG0457	Tetratricopeptide repeat
GFB63_RS03260	COG0705	Rhomboid family
GFB63_RS03265	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GFB63_RS03285	COG2226	methyltransferase
GFB63_RS03315	COG0425	Belongs to the sulfur carrier protein TusA family
GFB63_RS03320	COG2391	methyltransferase activity
GFB63_RS03325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFB63_RS03330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFB63_RS03340	COG1363	Peptidase, m42
GFB63_RS03345	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GFB63_RS03350	COG1266	CAAX protease self-immunity
GFB63_RS03405	COG1459	type II secretion system
GFB63_RS03410	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GFB63_RS03445	COG0440	acetolactate synthase activity
GFB63_RS03450	COG0028	Belongs to the TPP enzyme family
GFB63_RS03460	COG1461	Dihydroxyacetone kinase
GFB63_RS03470	COG0534	Mate efflux family protein
GFB63_RS03485	COG3590	peptidase
GFB63_RS03515	COG2188	Transcriptional regulator
GFB63_RS03520	COG4475	Protein of unknown function (DUF436)
GFB63_RS03565	COG2217	Heavy metal translocating P-type atpase
GFB63_RS03570	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GFB63_RS03595	COG0210	DNA helicase
GFB63_RS03630	COG0191	fructose-bisphosphate aldolase activity
GFB63_RS03700	COG0201	protein transport
GFB63_RS03805	COG0051	transcription antitermination factor activity, RNA binding
GFB63_RS03845	COG1396	sequence-specific DNA binding
GFB63_RS03850	COG0535	radical SAM domain protein
GFB63_RS03855	COG1132	(ABC) transporter
GFB63_RS03890	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GFB63_RS03930	COG0602	queuosine metabolic process
GFB63_RS03940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GFB63_RS03965	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GFB63_RS03975	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GFB63_RS03980	COG2801	Transposase and inactivated derivatives
GFB63_RS04000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GFB63_RS04005	COG1028	Short-chain dehydrogenase reductase Sdr
GFB63_RS04005	COG3321	synthase
GFB63_RS04005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GFB63_RS04005	COG4221	oxidoreductase activity
GFB63_RS04015	COG1136	(ABC) transporter
GFB63_RS04065	COG2261	transglycosylase associated protein
GFB63_RS04085	COG3237	CsbD-like
GFB63_RS04095	COG3328	transposase activity
GFB63_RS04110	COG1511	domain protein
GFB63_RS04110	COG1511	domain protein
GFB63_RS04140	COG0305	Participates in initiation and elongation during chromosome replication
GFB63_RS04175	COG0741	lytic transglycosylase activity
GFB63_RS04180	COG3584	3D domain protein
GFB63_RS04180	COG1388	LysM domain
GFB63_RS04185	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GFB63_RS04200	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GFB63_RS04210	COG0612	Peptidase, M16
GFB63_RS04240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GFB63_RS04245	COG0488	(ABC) transporter
GFB63_RS04280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFB63_RS04285	COG1475	DNA binding
GFB63_RS04295	COG0592	DNA-directed DNA polymerase activity
GFB63_RS04305	COG0012	GTP binding
GFB63_RS04315	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GFB63_RS04320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GFB63_RS04350	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFB63_RS04480	COG3942	CHAP domain
GFB63_RS04495	COG0436	Aminotransferase
GFB63_RS04510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GFB63_RS04520	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GFB63_RS04530	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GFB63_RS04535	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GFB63_RS04550	COG3942	CHAP domain
GFB63_RS04550	COG1388	LysM domain
GFB63_RS04555	COG0151	Belongs to the GarS family
GFB63_RS04560	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GFB63_RS04575	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GFB63_RS04665	COG4550	Control of competence regulator ComK, YlbF/YmcA
GFB63_RS04705	COG2818	Glycosylase
GFB63_RS04720	COG1393	Belongs to the ArsC family
GFB63_RS04810	COG2309	aminopeptidase activity
GFB63_RS04825	COG0431	NADPH-dependent FMN reductase
GFB63_RS04835	COG3634	alkyl hydroperoxide reductase activity
GFB63_RS04840	COG0450	alkyl hydroperoxide reductase
GFB63_RS04860	COG4463	regulation of RNA biosynthetic process
GFB63_RS04865	COG0542	response to heat
GFB63_RS04880	COG1686	Belongs to the peptidase S11 family
GFB63_RS04895	COG1045	serine acetyltransferase
GFB63_RS04905	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
GFB63_RS04925	COG3688	RNA-binding protein containing a PIN domain
GFB63_RS04945	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GFB63_RS04995	COG3830	Belongs to the UPF0237 family
GFB63_RS05005	COG0588	phosphoglycerate mutase activity
GFB63_RS05010	COG1876	peptidase activity
GFB63_RS05045	COG0351	phosphomethylpyrimidine kinase
GFB63_RS05050	COG4720	Psort location CytoplasmicMembrane, score
GFB63_RS05155	COG0668	transmembrane transport
GFB63_RS05170	COG0504	CTP synthase activity
GFB63_RS05195	COG0270	DNA (cytosine-5-)-methyltransferase activity
GFB63_RS05340	COG1396	sequence-specific DNA binding
GFB63_RS05345	COG0542	response to heat
GFB63_RS05355	COG4581	dead DEAH box helicase
GFB63_RS05375	COG3843	relaxase mobilization nuclease domain protein
GFB63_RS05400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GFB63_RS05405	COG2274	protein secretion by the type I secretion system
GFB63_RS05475	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GFB63_RS05515	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GFB63_RS05555	COG1126	abc transporter atp-binding protein
GFB63_RS05560	COG0765	amino acid transport
GFB63_RS05580	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GFB63_RS05590	COG0719	Fe-S assembly protein
GFB63_RS05595	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GFB63_RS05605	COG0719	Fe-S assembly protein
GFB63_RS05645	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GFB63_RS05670	COG1121	(ABC) transporter
GFB63_RS05675	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GFB63_RS05715	COG4589	Belongs to the CDS family
GFB63_RS05730	COG4120	Belongs to the binding-protein-dependent transport system permease family
GFB63_RS05735	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GFB63_RS05735	COG1116	anion transmembrane transporter activity
GFB63_RS05770	COG0564	pseudouridine synthase activity
GFB63_RS05775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GFB63_RS05825	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GFB63_RS05840	COG3579	cysteine-type endopeptidase activity
GFB63_RS05845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GFB63_RS05870	COG0116	Belongs to the methyltransferase superfamily
GFB63_RS05880	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GFB63_RS05900	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GFB63_RS05920	COG1254	Belongs to the acylphosphatase family
GFB63_RS05925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GFB63_RS05965	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GFB63_RS05985	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GFB63_RS05990	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GFB63_RS05995	COG1187	pseudouridine synthase activity
GFB63_RS06005	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GFB63_RS06010	COG0569	domain protein
GFB63_RS06020	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GFB63_RS06025	COG0671	phosphoesterase, PA-phosphatase related
GFB63_RS06040	COG2274	protein secretion by the type I secretion system
GFB63_RS06075	COG0804	urea catabolic process
GFB63_RS06095	COG0829	nickel cation binding
GFB63_RS06100	COG0310	cobalt ion transport
GFB63_RS06110	COG1122	ATPase activity
GFB63_RS06115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFB63_RS06120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GFB63_RS06140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFB63_RS06145	COG1464	Belongs to the NlpA lipoprotein family
GFB63_RS06155	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GFB63_RS06180	COG1122	ATPase activity
GFB63_RS06190	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GFB63_RS06200	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GFB63_RS06215	COG0745	RESPONSE REGULATOR receiver
GFB63_RS06220	COG5002	protein histidine kinase activity
GFB63_RS06235	COG1484	DNA-dependent DNA replication
GFB63_RS06250	COG1335	isochorismatase
GFB63_RS06270	COG3716	PTS system mannose fructose sorbose family IID component
GFB63_RS06275	COG3715	PTS system
GFB63_RS06285	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
GFB63_RS06290	COG0561	phosphatase activity
GFB63_RS06295	COG2252	PERMEase
GFB63_RS06300	COG0802	atpase or kinase
GFB63_RS06305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GFB63_RS06310	COG1316	TRANSCRIPTIONal
GFB63_RS06320	COG0195	Participates in both transcription termination and antitermination
GFB63_RS06325	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GFB63_RS06335	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GFB63_RS06360	COG2244	polysaccharide biosynthetic process
GFB63_RS06370	COG0626	cystathionine gamma-synthase activity
GFB63_RS06375	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GFB63_RS06405	COG4471	UPF0298 protein
GFB63_RS06415	COG0559	Belongs to the binding-protein-dependent transport system permease family
GFB63_RS06445	COG1739	Uncharacterized protein family UPF0029
GFB63_RS06450	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GFB63_RS06455	COG1040	competence protein
GFB63_RS06520	COG3328	transposase activity
GFB63_RS06550	COG0527	aspartate kinase activity
GFB63_RS06555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GFB63_RS06560	COG1024	Enoyl-CoA hydratase
GFB63_RS06565	COG1846	Transcriptional regulator
GFB63_RS06585	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GFB63_RS06590	COG1028	Short-chain dehydrogenase reductase Sdr
GFB63_RS06595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GFB63_RS06610	COG0439	Biotin carboxylase
GFB63_RS06640	COG1349	DNA-binding transcription factor activity
GFB63_RS06645	COG1105	Belongs to the carbohydrate kinase PfkB family
GFB63_RS06650	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GFB63_RS06650	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GFB63_RS06650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GFB63_RS06655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFB63_RS06660	COG0285	dihydrofolate synthase activity
GFB63_RS06670	COG1104	cysteine desulfurase activity
GFB63_RS06730	COG0488	(ABC) transporter
GFB63_RS06750	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GFB63_RS06755	COG0242	peptide deformylase activity
GFB63_RS06805	COG3942	CHAP domain
GFB63_RS06815	COG1702	phosphate starvation-inducible protein PhoH
GFB63_RS06840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFB63_RS06840	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFB63_RS06860	COG4122	O-methyltransferase activity
GFB63_RS06865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GFB63_RS06905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GFB63_RS06910	COG0436	Aminotransferase
GFB63_RS06925	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GFB63_RS06930	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GFB63_RS06935	COG0726	polysaccharide deacetylase
GFB63_RS06950	COG2962	Rard protein
GFB63_RS06975	COG0525	valine-tRNA ligase activity
GFB63_RS06985	COG0356	it plays a direct role in the translocation of protons across the membrane
GFB63_RS07020	COG0772	Belongs to the SEDS family
GFB63_RS07040	COG0470	DNA polymerase III
GFB63_RS07045	COG1774	PSP1 C-terminal conserved region
GFB63_RS07050	COG4467	Involved in initiation control of chromosome replication
GFB63_RS07075	COG0004	ammonium transporteR
GFB63_RS07080	COG0347	Belongs to the P(II) protein family
GFB63_RS07085	COG1705	Flagellar rod assembly protein muramidase FlgJ
GFB63_RS07085	COG1388	LysM domain
GFB63_RS07135	COG1113	amino acid transport
GFB63_RS07185	COG0564	pseudouridine synthase activity
GFB63_RS07205	COG0505	Belongs to the CarA family
GFB63_RS07280	COG0577	efflux transmembrane transporter activity
GFB63_RS07330	COG3279	Response regulator of the LytR AlgR family
GFB63_RS07340	COG1131	(ABC) transporter
GFB63_RS07375	COG1187	pseudouridine synthase activity
GFB63_RS07380	COG1473	amidohydrolase
GFB63_RS07385	COG0686	Belongs to the AlaDH PNT family
GFB63_RS07390	COG0686	Belongs to the AlaDH PNT family
GFB63_RS07395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFB63_RS07465	COG0438	transferase activity, transferring glycosyl groups
GFB63_RS07500	COG1272	protein, Hemolysin III
GFB63_RS07515	COG3425	synthase
GFB63_RS07525	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GFB63_RS07545	COG0833	amino acid
GFB63_RS07550	COG2040	homocysteine
GFB63_RS07570	COG0187	DNA topoisomerase II activity
GFB63_RS07580	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GFB63_RS07600	COG0539	negative regulation of cytoplasmic translation
GFB63_RS07640	COG0494	nUDIX hydrolase
GFB63_RS07645	COG0542	response to heat
GFB63_RS07650	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GFB63_RS07655	COG4703	Protein of unknown function (DUF1797)
GFB63_RS07660	COG0765	amino acid transport
GFB63_RS07700	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GFB63_RS07705	COG0768	penicillin binding
GFB63_RS07710	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GFB63_RS07725	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GFB63_RS07730	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GFB63_RS07735	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GFB63_RS07740	COG0237	dephospho-CoA kinase activity
GFB63_RS07745	COG2814	Major facilitator Superfamily
GFB63_RS07760	COG0557	exoribonuclease II activity
GFB63_RS07775	COG1185	polyribonucleotide nucleotidyltransferase activity
GFB63_RS07780	COG0006	proline dipeptidase activity
GFB63_RS07785	COG1609	Transcriptional regulator
GFB63_RS07820	COG1368	sulfuric ester hydrolase activity
GFB63_RS07825	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GFB63_RS07850	COG0287	Prephenate dehydrogenase
GFB63_RS07875	COG0077	Prephenate dehydratase
GFB63_RS07985	COG1518	maintenance of DNA repeat elements
GFB63_RS07990	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
GFB63_RS08000	COG3689	TIGRFAM TIGR03943 family protein
GFB63_RS08005	COG0701	Predicted permease
GFB63_RS08010	COG2183	response to ionizing radiation
GFB63_RS08030	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GFB63_RS08055	COG0826	peptidase U32
GFB63_RS08065	COG1268	BioY protein
GFB63_RS08075	COG4443	Transcriptional Coactivator p15 (PC4)
GFB63_RS08080	COG1914	H( )-stimulated, divalent metal cation uptake system
GFB63_RS08110	COG3328	transposase activity
GFB63_RS08150	COG0406	alpha-ribazole phosphatase activity
GFB63_RS08155	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GFB63_RS08190	COG4221	oxidoreductase activity
GFB63_RS08200	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GFB63_RS08250	COG1704	LemA family
GFB63_RS08255	COG0501	Belongs to the peptidase M48B family
GFB63_RS08280	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GFB63_RS08295	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GFB63_RS08300	COG0783	Belongs to the Dps family
GFB63_RS08310	COG0783	Belongs to the Dps family
GFB63_RS08320	COG0783	Belongs to the Dps family
GFB63_RS08325	COG0735	belongs to the Fur family
GFB63_RS08330	COG4483	Protein conserved in bacteria
GFB63_RS08335	COG1940	carbohydrate kinase activity
GFB63_RS08340	COG1217	gtp-binding protein TYPA
GFB63_RS08375	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GFB63_RS08400	COG3599	regulation of cell shape
GFB63_RS08430	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GFB63_RS08435	COG0625	glutathione transferase activity
GFB63_RS08440	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GFB63_RS08445	COG1435	thymidine kinase activity
GFB63_RS08455	COG2890	protein-(glutamine-N5) methyltransferase activity
GFB63_RS08485	COG1132	(ABC) transporter
GFB63_RS08500	COG1696	Membrane protein involved in D-alanine export
GFB63_RS08510	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
GFB63_RS08520	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GFB63_RS08525	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GFB63_RS08545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GFB63_RS08550	COG4684	Psort location CytoplasmicMembrane, score
GFB63_RS08555	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GFB63_RS08570	COG0745	RESPONSE REGULATOR receiver
GFB63_RS08585	COG5002	protein histidine kinase activity
GFB63_RS08600	COG2813	Specifically methylates the guanine in position
GFB63_RS08615	COG0295	cytidine deaminase activity
GFB63_RS08620	COG1744	ABC transporter substrate-binding protein PnrA-like
GFB63_RS08625	COG3845	ABC transporter
GFB63_RS08630	COG4603	Belongs to the binding-protein-dependent transport system permease family
GFB63_RS08635	COG1079	Belongs to the binding-protein-dependent transport system permease family
GFB63_RS08645	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GFB63_RS08645	COG1199	ATP-dependent helicase activity
GFB63_RS08655	COG0436	Aminotransferase
GFB63_RS08660	COG0017	Asparaginyl-tRNA synthetase
GFB63_RS08675	COG0251	oxidation-reduction process
GFB63_RS08685	COG0720	synthase
GFB63_RS08700	COG3328	transposase activity
GFB63_RS08755	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
GFB63_RS08765	COG3328	transposase activity
GFB63_RS08885	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GFB63_RS08885	COG0551	DNA topoisomerase type I activity
GFB63_RS08890	COG0542	response to heat
GFB63_RS08925	COG1472	Belongs to the glycosyl hydrolase 3 family
GFB63_RS08955	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GFB63_RS09015	COG0335	large ribosomal subunit rRNA binding
GFB63_RS09030	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GFB63_RS09035	COG1956	GAF domain-containing protein
GFB63_RS09040	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GFB63_RS09050	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GFB63_RS09050	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GFB63_RS09055	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GFB63_RS09070	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GFB63_RS09095	COG0765	amino acid transport
GFB63_RS09100	COG0765	amino acid transport
GFB63_RS09105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFB63_RS09110	COG1126	abc transporter atp-binding protein
GFB63_RS09115	COG0745	RESPONSE REGULATOR receiver
GFB63_RS09120	COG5002	protein histidine kinase activity
GFB63_RS09125	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GFB63_RS09135	COG2348	transferase activity, transferring amino-acyl groups
GFB63_RS09170	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GFB63_RS09180	COG2884	Cell division ATP-binding protein ftsE
GFB63_RS09185	COG2177	Part of the ABC transporter FtsEX involved in
GFB63_RS09190	COG1051	belongs to the nudix hydrolase family
GFB63_RS09195	COG0628	permease
GFB63_RS09205	COG0681	Belongs to the peptidase S26 family
GFB63_RS09235	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GFB63_RS09240	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GFB63_RS09270	COG1573	uracil-dna glycosylase
GFB63_RS09300	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GFB63_RS09320	COG1316	TRANSCRIPTIONal
GFB63_RS09355	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GFB63_RS09380	COG1216	Glycosyl transferase, family 2
GFB63_RS09380	COG1442	glycosyl transferase family 8
GFB63_RS09400	COG0562	UDP-galactopyranose mutase
GFB63_RS09410	COG0438	transferase activity, transferring glycosyl groups
GFB63_RS09445	COG0628	permease
GFB63_RS09485	COG4667	esterase of the alpha-beta hydrolase superfamily
GFB63_RS09495	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GFB63_RS09515	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GFB63_RS09520	COG0508	dehydrogenase complex catalyzes the overall conversion of
GFB63_RS09520	COG0022	dehydrogenase e1 component
GFB63_RS09525	COG0508	dehydrogenase complex catalyzes the overall conversion of
GFB63_RS09545	COG1523	belongs to the glycosyl hydrolase 13 family
GFB63_RS09555	COG1523	belongs to the glycosyl hydrolase 13 family
GFB63_RS09570	COG2822	iron ion transport
GFB63_RS09575	COG2837	iron assimilation
GFB63_RS09580	COG0672	)-iron permease
GFB63_RS09585	COG0805	protein transport
GFB63_RS09590	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GFB63_RS09615	COG1609	Transcriptional regulator
GFB63_RS09625	COG1640	4-alpha-glucanotransferase
GFB63_RS09630	COG0058	SHG alpha-glucan phosphorylase activity
GFB63_RS09645	COG0095	Lipoate-protein ligase
GFB63_RS09660	COG0704	Plays a role in the regulation of phosphate uptake
GFB63_RS09675	COG0581	inorganic phosphate transmembrane transporter activity
GFB63_RS09680	COG0573	inorganic phosphate transmembrane transporter activity
GFB63_RS09690	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GFB63_RS09690	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GFB63_RS09695	COG0483	inositol monophosphate 1-phosphatase activity
GFB63_RS09705	COG1393	Belongs to the ArsC family
GFB63_RS09710	COG0196	riboflavin kinase activity
GFB63_RS09715	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GFB63_RS09745	COG2873	o-acetylhomoserine
GFB63_RS09755	COG1115	amino acid carrier protein
GFB63_RS09795	COG0154	amidase activity
GFB63_RS09800	COG3104	oligopeptide transport
GFB63_RS09815	COG0284	orotidine-5'-phosphate decarboxylase activity
GFB63_RS09820	COG0167	dihydroorotate dehydrogenase activity
GFB63_RS09840	COG1293	RNA-binding protein homologous to eukaryotic snRNP
GFB63_RS09855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GFB63_RS09880	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GFB63_RS09890	COG1230	cation diffusion facilitator family transporter
GFB63_RS09915	COG3527	Alpha-acetolactate decarboxylase
GFB63_RS09920	COG0028	Belongs to the TPP enzyme family
GFB63_RS09930	COG0010	Belongs to the arginase family
GFB63_RS09935	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GFB63_RS09950	COG1396	sequence-specific DNA binding
GFB63_RS09970	COG0481	GTPase activity
GFB63_RS09985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFB63_RS10025	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GFB63_RS10030	COG0758	DNA mediated transformation
GFB63_RS10035	COG1940	carbohydrate kinase activity
GFB63_RS10045	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GFB63_RS10055	COG1827	regulation of RNA biosynthetic process
GFB63_RS10070	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GFB63_RS10080	COG2188	Transcriptional regulator
GFB63_RS10085	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GFB63_RS10085	COG0519	Catalyzes the synthesis of GMP from XMP
GFB63_RS10090	COG2189	Belongs to the N(4) N(6)-methyltransferase family
GFB63_RS10105	COG1064	alcohol dehydrogenase
GFB63_RS10110	COG1064	alcohol dehydrogenase
GFB63_RS10120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFB63_RS10125	COG1126	abc transporter atp-binding protein
GFB63_RS10130	COG0765	amino acid transport
GFB63_RS10135	COG2824	Alkylphosphonate utilization operon protein PhnA
GFB63_RS10140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GFB63_RS10155	COG1705	Flagellar rod assembly protein muramidase FlgJ
GFB63_RS10155	COG3942	CHAP domain
GFB63_RS10170	COG3443	Belongs to the bacterial solute-binding protein 9 family
GFB63_RS10170	COG0803	Belongs to the bacterial solute-binding protein 9 family
GFB63_RS10220	COG4975	Glucose uptake
GFB63_RS10225	COG3328	transposase activity
GFB63_RS10230	COG2217	Heavy metal translocating P-type atpase
GFB63_RS10235	COG3328	transposase activity
GFB63_RS10245	COG1278	Cold shock