locus-tag	class	description
NN994_RS00010	COG0592	DNA-directed DNA polymerase activity
NN994_RS00020	COG0012	GTP binding
NN994_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NN994_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NN994_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NN994_RS00195	COG3942	CHAP domain
NN994_RS00210	COG0436	Aminotransferase
NN994_RS00225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NN994_RS00235	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NN994_RS00240	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NN994_RS00250	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NN994_RS00265	COG1388	LysM domain
NN994_RS00265	COG3942	CHAP domain
NN994_RS00270	COG0151	Belongs to the GarS family
NN994_RS00275	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NN994_RS00295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NN994_RS00310	COG4550	Control of competence regulator ComK, YlbF/YmcA
NN994_RS00355	COG2818	Glycosylase
NN994_RS00370	COG1393	Belongs to the ArsC family
NN994_RS00460	COG2309	aminopeptidase activity
NN994_RS00475	COG0431	NADPH-dependent FMN reductase
NN994_RS00510	COG4463	regulation of RNA biosynthetic process
NN994_RS00515	COG0542	response to heat
NN994_RS00530	COG1686	Belongs to the peptidase S11 family
NN994_RS00545	COG1045	serine acetyltransferase
NN994_RS00555	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
NN994_RS00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NN994_RS00600	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NN994_RS00650	COG2189	Belongs to the N(4) N(6)-methyltransferase family
NN994_RS00655	COG3421	Type III restriction
NN994_RS00695	COG3830	Belongs to the UPF0237 family
NN994_RS00710	COG1876	peptidase activity
NN994_RS00745	COG0351	phosphomethylpyrimidine kinase
NN994_RS00865	COG1473	amidohydrolase
NN994_RS00870	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NN994_RS00890	COG0668	transmembrane transport
NN994_RS00905	COG0504	CTP synthase activity
NN994_RS00915	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NN994_RS00925	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NN994_RS00930	COG0737	Belongs to the 5'-nucleotidase family
NN994_RS00965	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NN994_RS01005	COG1126	abc transporter atp-binding protein
NN994_RS01010	COG0765	amino acid transport
NN994_RS01030	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NN994_RS01040	COG0719	Fe-S assembly protein
NN994_RS01045	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NN994_RS01055	COG0719	Fe-S assembly protein
NN994_RS01080	COG4608	Belongs to the ABC transporter superfamily
NN994_RS01095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NN994_RS01110	COG1121	(ABC) transporter
NN994_RS01115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NN994_RS01155	COG4589	Belongs to the CDS family
NN994_RS01170	COG4120	Belongs to the binding-protein-dependent transport system permease family
NN994_RS01175	COG1116	anion transmembrane transporter activity
NN994_RS01175	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NN994_RS01210	COG0564	pseudouridine synthase activity
NN994_RS01215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NN994_RS01245	COG1349	DNA-binding transcription factor activity
NN994_RS01270	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NN994_RS01285	COG3579	cysteine-type endopeptidase activity
NN994_RS01290	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NN994_RS01315	COG0116	Belongs to the methyltransferase superfamily
NN994_RS01325	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NN994_RS01345	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NN994_RS01365	COG1254	Belongs to the acylphosphatase family
NN994_RS01370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NN994_RS01415	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NN994_RS01435	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NN994_RS01440	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NN994_RS01445	COG1187	pseudouridine synthase activity
NN994_RS01455	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NN994_RS01460	COG0569	domain protein
NN994_RS01470	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
NN994_RS01475	COG0671	phosphoesterase, PA-phosphatase related
NN994_RS01490	COG2274	protein secretion by the type I secretion system
NN994_RS01495	COG2274	protein secretion by the type I secretion system
NN994_RS01555	COG0829	nickel cation binding
NN994_RS01560	COG0310	cobalt ion transport
NN994_RS01570	COG1122	ATPase activity
NN994_RS01575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NN994_RS01580	COG1464	Belongs to the NlpA lipoprotein family
NN994_RS01590	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NN994_RS01615	COG1122	ATPase activity
NN994_RS01625	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NN994_RS01640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NN994_RS01655	COG0745	RESPONSE REGULATOR receiver
NN994_RS01660	COG5002	protein histidine kinase activity
NN994_RS01675	COG1484	DNA-dependent DNA replication
NN994_RS01715	COG3716	PTS system mannose fructose sorbose family IID component
NN994_RS01720	COG3715	PTS system
NN994_RS01730	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
NN994_RS01735	COG0561	phosphatase activity
NN994_RS01740	COG2252	PERMEase
NN994_RS01745	COG0802	atpase or kinase
NN994_RS01750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NN994_RS01755	COG1316	TRANSCRIPTIONal
NN994_RS01765	COG0195	Participates in both transcription termination and antitermination
NN994_RS01770	COG2740	Nucleic-acid-binding protein implicated in transcription termination
NN994_RS01790	COG1611	Belongs to the LOG family
NN994_RS01810	COG2244	polysaccharide biosynthetic process
NN994_RS01815	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NN994_RS01820	COG0626	cystathionine gamma-synthase activity
NN994_RS01825	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NN994_RS01855	COG4471	UPF0298 protein
NN994_RS01865	COG0559	Belongs to the binding-protein-dependent transport system permease family
NN994_RS01895	COG1739	Uncharacterized protein family UPF0029
NN994_RS01900	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
NN994_RS01905	COG1040	competence protein
NN994_RS01995	COG0527	aspartate kinase activity
NN994_RS02000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NN994_RS02005	COG1024	Enoyl-CoA hydratase
NN994_RS02010	COG1846	Transcriptional regulator
NN994_RS02030	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NN994_RS02035	COG1028	Short-chain dehydrogenase reductase Sdr
NN994_RS02040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NN994_RS02055	COG0439	Biotin carboxylase
NN994_RS02095	COG1349	DNA-binding transcription factor activity
NN994_RS02100	COG1105	Belongs to the carbohydrate kinase PfkB family
NN994_RS02110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NN994_RS02115	COG0285	dihydrofolate synthase activity
NN994_RS02125	COG1104	cysteine desulfurase activity
NN994_RS02190	COG0488	(ABC) transporter
NN994_RS02210	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NN994_RS02215	COG0242	peptide deformylase activity
NN994_RS02275	COG1702	phosphate starvation-inducible protein PhoH
NN994_RS02300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NN994_RS02300	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NN994_RS02320	COG4122	O-methyltransferase activity
NN994_RS02325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NN994_RS02355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NN994_RS02360	COG0436	Aminotransferase
NN994_RS02375	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NN994_RS02380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NN994_RS02385	COG0726	polysaccharide deacetylase
NN994_RS02400	COG2962	Rard protein
NN994_RS02435	COG0356	it plays a direct role in the translocation of protons across the membrane
NN994_RS02470	COG0772	Belongs to the SEDS family
NN994_RS02490	COG0470	DNA polymerase III
NN994_RS02495	COG1774	PSP1 C-terminal conserved region
NN994_RS02500	COG4467	Involved in initiation control of chromosome replication
NN994_RS02510	COG0004	ammonium transporteR
NN994_RS02515	COG0347	Belongs to the P(II) protein family
NN994_RS02520	COG1705	Flagellar rod assembly protein muramidase FlgJ
NN994_RS02520	COG1388	LysM domain
NN994_RS02585	COG1113	amino acid transport
NN994_RS02625	COG0583	DNA-binding transcription factor activity
NN994_RS02635	COG0564	pseudouridine synthase activity
NN994_RS02655	COG0505	Belongs to the CarA family
NN994_RS02690	COG0577	efflux transmembrane transporter activity
NN994_RS02695	COG0577	efflux transmembrane transporter activity
NN994_RS02725	COG0577	efflux transmembrane transporter activity
NN994_RS02770	COG3279	Response regulator of the LytR AlgR family
NN994_RS02780	COG1131	(ABC) transporter
NN994_RS02815	COG1187	pseudouridine synthase activity
NN994_RS02820	COG1473	amidohydrolase
NN994_RS02825	COG0686	Belongs to the AlaDH PNT family
NN994_RS02835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NN994_RS02905	COG0438	transferase activity, transferring glycosyl groups
NN994_RS02940	COG1272	protein, Hemolysin III
NN994_RS02955	COG3425	synthase
NN994_RS02965	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NN994_RS02980	COG0833	amino acid
NN994_RS02985	COG2040	homocysteine
NN994_RS03005	COG0187	DNA topoisomerase II activity
NN994_RS03015	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NN994_RS03035	COG0539	negative regulation of cytoplasmic translation
NN994_RS03075	COG0494	nUDIX hydrolase
NN994_RS03080	COG0542	response to heat
NN994_RS03085	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NN994_RS03090	COG4703	Protein of unknown function (DUF1797)
NN994_RS03095	COG0765	amino acid transport
NN994_RS03150	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NN994_RS03155	COG0768	penicillin binding
NN994_RS03175	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NN994_RS03180	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NN994_RS03185	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NN994_RS03190	COG0237	dephospho-CoA kinase activity
NN994_RS03210	COG0557	exoribonuclease II activity
NN994_RS03225	COG1185	polyribonucleotide nucleotidyltransferase activity
NN994_RS03230	COG0006	proline dipeptidase activity
NN994_RS03235	COG1609	Transcriptional regulator
NN994_RS03275	COG1368	sulfuric ester hydrolase activity
NN994_RS03280	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NN994_RS03305	COG0287	Prephenate dehydrogenase
NN994_RS03330	COG0077	Prephenate dehydratase
NN994_RS03390	COG1518	maintenance of DNA repeat elements
NN994_RS03395	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
NN994_RS03405	COG3689	TIGRFAM TIGR03943 family protein
NN994_RS03410	COG0701	Predicted permease
NN994_RS03420	COG2183	response to ionizing radiation
NN994_RS03465	COG0826	peptidase U32
NN994_RS03475	COG1268	BioY protein
NN994_RS03485	COG4443	Transcriptional Coactivator p15 (PC4)
NN994_RS03490	COG1914	H( )-stimulated, divalent metal cation uptake system
NN994_RS03500	COG0494	nUDIX hydrolase
NN994_RS03515	COG1705	Flagellar rod assembly protein muramidase FlgJ
NN994_RS03515	COG1388	LysM domain
NN994_RS03530	COG0406	alpha-ribazole phosphatase activity
NN994_RS03535	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NN994_RS03575	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
NN994_RS03605	COG1704	LemA family
NN994_RS03635	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NN994_RS03645	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NN994_RS03650	COG0783	Belongs to the Dps family
NN994_RS03655	COG0735	belongs to the Fur family
NN994_RS03660	COG4483	Protein conserved in bacteria
NN994_RS03665	COG1940	carbohydrate kinase activity
NN994_RS03670	COG1217	gtp-binding protein TYPA
NN994_RS03695	COG0849	cell division
NN994_RS03705	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NN994_RS03730	COG3599	regulation of cell shape
NN994_RS03760	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NN994_RS03765	COG0625	glutathione transferase activity
NN994_RS03775	COG1435	thymidine kinase activity
NN994_RS03785	COG2890	protein-(glutamine-N5) methyltransferase activity
NN994_RS03815	COG1132	(ABC) transporter
NN994_RS03830	COG1696	Membrane protein involved in D-alanine export
NN994_RS03840	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
NN994_RS03850	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NN994_RS03855	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NN994_RS03875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NN994_RS03880	COG4684	Psort location CytoplasmicMembrane, score
NN994_RS03885	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NN994_RS03935	COG0038	chloride channel
NN994_RS03970	COG2813	Specifically methylates the guanine in position
NN994_RS03985	COG0295	cytidine deaminase activity
NN994_RS03990	COG1744	ABC transporter substrate-binding protein PnrA-like
NN994_RS03995	COG3845	ABC transporter
NN994_RS04000	COG4603	Belongs to the binding-protein-dependent transport system permease family
NN994_RS04005	COG1079	Belongs to the binding-protein-dependent transport system permease family
NN994_RS04015	COG1199	ATP-dependent helicase activity
NN994_RS04015	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NN994_RS04025	COG0436	Aminotransferase
NN994_RS04045	COG0251	oxidation-reduction process
NN994_RS04055	COG0720	synthase
NN994_RS04105	COG1278	Cold shock
NN994_RS04115	COG3328	transposase activity
NN994_RS04120	COG2217	Heavy metal translocating P-type atpase
NN994_RS04125	COG3328	transposase activity
NN994_RS04135	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NN994_RS04140	COG0626	cystathionine gamma-synthase activity
NN994_RS04145	COG1045	serine acetyltransferase
NN994_RS04165	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
NN994_RS04175	COG4975	Glucose uptake
NN994_RS04195	COG3443	Belongs to the bacterial solute-binding protein 9 family
NN994_RS04195	COG0803	Belongs to the bacterial solute-binding protein 9 family
NN994_RS04215	COG3942	CHAP domain
NN994_RS04215	COG1705	Flagellar rod assembly protein muramidase FlgJ
NN994_RS04230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NN994_RS04235	COG2824	Alkylphosphonate utilization operon protein PhnA
NN994_RS04240	COG0765	amino acid transport
NN994_RS04245	COG1126	abc transporter atp-binding protein
NN994_RS04250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NN994_RS04280	COG3421	Type III restriction
NN994_RS04285	COG2189	Belongs to the N(4) N(6)-methyltransferase family
NN994_RS04290	COG0519	Catalyzes the synthesis of GMP from XMP
NN994_RS04290	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NN994_RS04295	COG2188	Transcriptional regulator
NN994_RS04305	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NN994_RS04325	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NN994_RS04335	COG1940	carbohydrate kinase activity
NN994_RS04340	COG0758	DNA mediated transformation
NN994_RS04345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NN994_RS04390	COG0481	GTPase activity
NN994_RS04395	COG1396	sequence-specific DNA binding
NN994_RS04410	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NN994_RS04415	COG0010	Belongs to the arginase family
NN994_RS04425	COG0028	Belongs to the TPP enzyme family
NN994_RS04430	COG3527	Alpha-acetolactate decarboxylase
NN994_RS04455	COG1230	cation diffusion facilitator family transporter
NN994_RS04465	COG1063	alcohol dehydrogenase
NN994_RS04485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NN994_RS04490	COG4607	ABC-type enterochelin transport system periplasmic component
NN994_RS04505	COG1293	RNA-binding protein homologous to eukaryotic snRNP
NN994_RS04540	COG0047	phosphoribosylformylglycinamidine synthase activity
NN994_RS04555	COG0167	dihydroorotate dehydrogenase activity
NN994_RS04565	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
NN994_RS04585	COG1337	RAMP superfamily
NN994_RS04590	COG1567	CRISPR-associated RAMP protein, Csm4 family
NN994_RS04605	COG0284	orotidine-5'-phosphate decarboxylase activity
NN994_RS04625	COG3104	oligopeptide transport
NN994_RS04635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NN994_RS04650	COG0737	Belongs to the 5'-nucleotidase family
NN994_RS04675	COG1115	amino acid carrier protein
NN994_RS04685	COG2873	o-acetylhomoserine
NN994_RS04715	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NN994_RS04720	COG0196	riboflavin kinase activity
NN994_RS04725	COG1393	Belongs to the ArsC family
NN994_RS04735	COG0483	inositol monophosphate 1-phosphatase activity
NN994_RS04740	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NN994_RS04740	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
NN994_RS04750	COG0573	inorganic phosphate transmembrane transporter activity
NN994_RS04755	COG0581	inorganic phosphate transmembrane transporter activity
NN994_RS04770	COG0704	Plays a role in the regulation of phosphate uptake
NN994_RS04785	COG0095	Lipoate-protein ligase
NN994_RS04795	COG0058	SHG alpha-glucan phosphorylase activity
NN994_RS04800	COG1640	4-alpha-glucanotransferase
NN994_RS04820	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NN994_RS04825	COG0805	protein transport
NN994_RS04830	COG0672	)-iron permease
NN994_RS04835	COG2837	iron assimilation
NN994_RS04840	COG2822	iron ion transport
NN994_RS04845	COG4607	ABC-type enterochelin transport system periplasmic component
NN994_RS04850	COG4604	ABC transporter, ATP-binding protein
NN994_RS04855	COG4605	iron ion homeostasis
NN994_RS04860	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NN994_RS04885	COG0508	dehydrogenase complex catalyzes the overall conversion of
NN994_RS04890	COG0508	dehydrogenase complex catalyzes the overall conversion of
NN994_RS04890	COG0022	dehydrogenase e1 component
NN994_RS04895	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NN994_RS04925	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NN994_RS04935	COG4667	esterase of the alpha-beta hydrolase superfamily
NN994_RS04970	COG0628	permease
NN994_RS04980	COG0561	phosphatase activity
NN994_RS05010	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NN994_RS05030	COG4641	Protein conserved in bacteria
NN994_RS05030	COG0438	transferase activity, transferring glycosyl groups
NN994_RS05040	COG1216	Glycosyl transferase, family 2
NN994_RS05040	COG1442	glycosyl transferase family 8
NN994_RS05080	COG1316	TRANSCRIPTIONal
NN994_RS05100	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NN994_RS05110	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
NN994_RS05130	COG1573	uracil-dna glycosylase
NN994_RS05195	COG0681	Belongs to the peptidase S26 family
NN994_RS05205	COG0628	permease
NN994_RS05210	COG1051	belongs to the nudix hydrolase family
NN994_RS05215	COG2177	Part of the ABC transporter FtsEX involved in
NN994_RS05220	COG2884	Cell division ATP-binding protein ftsE
NN994_RS05230	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NN994_RS05265	COG2348	transferase activity, transferring amino-acyl groups
NN994_RS05275	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NN994_RS05280	COG5002	protein histidine kinase activity
NN994_RS05285	COG0745	RESPONSE REGULATOR receiver
NN994_RS05290	COG1126	abc transporter atp-binding protein
NN994_RS05295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NN994_RS05300	COG0765	amino acid transport
NN994_RS05305	COG0765	amino acid transport
NN994_RS05330	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NN994_RS05340	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NN994_RS05345	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NN994_RS05345	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NN994_RS05355	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NN994_RS05360	COG1956	GAF domain-containing protein
NN994_RS05365	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NN994_RS05380	COG0335	large ribosomal subunit rRNA binding
NN994_RS05385	COG0038	chloride channel
NN994_RS05395	COG0038	chloride channel
NN994_RS05400	COG0716	FMN binding
NN994_RS05465	COG0469	pyruvate kinase activity
NN994_RS05515	COG0167	dihydroorotate dehydrogenase activity
NN994_RS05525	COG0776	regulation of translation
NN994_RS05535	COG2755	lipolytic protein G-D-S-L family
NN994_RS05540	COG1307	EDD domain protein, DegV family
NN994_RS05545	COG0497	DNA recombination
NN994_RS05550	COG1438	arginine binding
NN994_RS05555	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
NN994_RS05580	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NN994_RS05600	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NN994_RS05600	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
NN994_RS05605	COG0300	oxidoreductase activity
NN994_RS05620	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NN994_RS05640	COG0107	imidazoleglycerol-phosphate synthase activity
NN994_RS05650	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NN994_RS05660	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NN994_RS05705	COG0647	UMP catabolic process
NN994_RS05715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NN994_RS05740	COG1088	dTDP-glucose 4,6-dehydratase activity
NN994_RS05750	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NN994_RS05755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NN994_RS05770	COG2384	SAM-dependent methyltransferase
NN994_RS05795	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NN994_RS05800	COG3442	glutamine amidotransferase
NN994_RS05805	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NN994_RS05805	COG0392	lysyltransferase activity
NN994_RS05815	COG0488	(ABC) transporter
NN994_RS05825	COG0513	Belongs to the DEAD box helicase family
NN994_RS05860	COG0372	Belongs to the citrate synthase family
NN994_RS05865	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NN994_RS05870	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NN994_RS05875	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NN994_RS05880	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NN994_RS05905	COG0346	lactoylglutathione lyase activity
NN994_RS05910	COG3764	Sortase (surface protein transpeptidase)
NN994_RS05930	COG0488	(ABC) transporter
NN994_RS05955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NN994_RS05960	COG1328	CTP reductase activity
NN994_RS05960	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NN994_RS05985	COG1196	nuclear chromosome segregation
NN994_RS06000	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NN994_RS06015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NN994_RS06025	COG1011	Hydrolase
NN994_RS06030	COG1268	BioY protein
NN994_RS06040	COG1125	glycine betaine transport
NN994_RS06040	COG0517	IMP dehydrogenase activity
NN994_RS06055	COG2986	histidine ammonia-lyase
NN994_RS06065	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NN994_RS06075	COG2197	response regulator
NN994_RS06080	COG4585	Histidine kinase
NN994_RS06090	COG1131	(ABC) transporter
NN994_RS06165	COG0577	efflux transmembrane transporter activity
NN994_RS06170	COG1136	(ABC) transporter
NN994_RS06175	COG5002	protein histidine kinase activity
NN994_RS06175	COG2198	Histidine kinase
NN994_RS06175	COG0784	Response regulator, receiver
NN994_RS06180	COG0745	RESPONSE REGULATOR receiver
NN994_RS06195	COG0534	Mate efflux family protein
NN994_RS06200	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NN994_RS06200	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NN994_RS06220	COG0531	amino acid
NN994_RS06230	COG2514	catechol 2,3-dioxygenase activity
NN994_RS06235	COG1959	2 iron, 2 sulfur cluster binding
NN994_RS06245	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NN994_RS06245	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NN994_RS06250	COG0778	Nitroreductase
NN994_RS06260	COG0656	L-ascorbic acid biosynthetic process
NN994_RS06305	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NN994_RS06330	COG1280	lysine exporter protein (LysE YggA)
NN994_RS06340	COG1216	Glycosyl transferase, family 2
NN994_RS06340	COG1442	glycosyl transferase family 8
NN994_RS06350	COG0577	efflux transmembrane transporter activity
NN994_RS06405	COG1396	sequence-specific DNA binding
NN994_RS06425	COG0419	ATPase involved in DNA repair
NN994_RS06430	COG0420	3'-5' exonuclease activity
NN994_RS06440	COG3250	beta-galactosidase activity
NN994_RS06445	COG2190	(PTS) system
NN994_RS06445	COG2211	Major facilitator Superfamily
NN994_RS06450	COG2017	converts alpha-aldose to the beta-anomer
NN994_RS06455	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NN994_RS06470	COG1609	Transcriptional regulator
NN994_RS06550	COG2197	response regulator
NN994_RS06555	COG4585	Histidine kinase
NN994_RS06570	COG2815	serine threonine protein kinase
NN994_RS06570	COG0515	serine threonine protein kinase
NN994_RS06580	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NN994_RS06580	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NN994_RS06590	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NN994_RS06605	COG0552	protein localization to endoplasmic reticulum
NN994_RS06610	COG0561	phosphatase activity
NN994_RS06615	COG0561	phosphatase activity
NN994_RS06620	COG1725	Transcriptional regulator
NN994_RS06625	COG1131	(ABC) transporter
NN994_RS06635	COG4608	Belongs to the ABC transporter superfamily
NN994_RS06640	COG0444	Belongs to the ABC transporter superfamily
NN994_RS06645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NN994_RS06650	COG0601	transmembrane transport
NN994_RS06655	COG4166	transmembrane transport
NN994_RS06675	COG2223	nitrite transmembrane transporter activity
NN994_RS06685	COG0280	phosphate acetyltransferase
NN994_RS06690	COG0564	pseudouridine synthase activity
NN994_RS06700	COG2357	RelA SpoT domain protein
NN994_RS06715	COG1104	cysteine desulfurase activity
NN994_RS06730	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NN994_RS06765	COG1215	transferase activity, transferring glycosyl groups
NN994_RS06785	COG0463	Glycosyl transferase, family 2
NN994_RS06790	COG1216	Glycosyl transferase, family 2
NN994_RS06795	COG1216	Glycosyl transferase, family 2
NN994_RS06805	COG1091	dTDP-4-dehydrorhamnose reductase activity
NN994_RS06815	COG0463	Glycosyl transferase, family 2
NN994_RS06820	COG2151	metal-sulfur cluster biosynthetic enzyme
NN994_RS06825	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NN994_RS06830	COG0358	DNA primase activity
NN994_RS06845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NN994_RS06850	COG0436	Aminotransferase
NN994_RS06855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NN994_RS06860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NN994_RS06865	COG1051	belongs to the nudix hydrolase family
NN994_RS06885	COG0765	amino acid transport
NN994_RS06890	COG1126	abc transporter atp-binding protein
NN994_RS06910	COG1187	pseudouridine synthase activity
NN994_RS06955	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
NN994_RS06960	COG1518	maintenance of DNA repeat elements
NN994_RS06965	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
NN994_RS06970	COG0560	Phosphoserine phosphatase
NN994_RS06980	COG0187	DNA topoisomerase II activity
NN994_RS06990	COG1346	cytolysis
NN994_RS06995	COG1380	Effector of murein hydrolase LrgA
NN994_RS07005	COG1393	Belongs to the ArsC family
NN994_RS07015	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NN994_RS07050	COG1177	transmembrane transport
NN994_RS07055	COG1176	ABC-type spermidine putrescine transport system, permease component I
NN994_RS07095	COG0531	amino acid
NN994_RS07100	COG0285	dihydrofolate synthase activity
NN994_RS07105	COG1837	Belongs to the UPF0109 family
NN994_RS07115	COG3615	Tellurite resistance protein tehB
NN994_RS07115	COG0500	methyltransferase
NN994_RS07125	COG0708	Exodeoxyribonuclease III
NN994_RS07140	COG1597	lipid kinase activity
NN994_RS07150	COG4708	membrane
NN994_RS07160	COG0024	Methionine aminopeptidase
NN994_RS07165	COG4109	DRTGG domain
NN994_RS07175	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NN994_RS07180	COG2333	competence protein COMEC
NN994_RS07180	COG0658	competence protein
NN994_RS07185	COG1596	polysaccharide export
NN994_RS07185	COG1555	photosystem II stabilization
NN994_RS07190	COG0204	Acyl-transferase
NN994_RS07200	COG0726	polysaccharide deacetylase
NN994_RS07205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NN994_RS07215	COG0513	Belongs to the DEAD box helicase family
NN994_RS07235	COG1396	sequence-specific DNA binding
NN994_RS07255	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NN994_RS07270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NN994_RS07275	COG1126	abc transporter atp-binding protein
NN994_RS07280	COG0765	amino acid transport
NN994_RS07285	COG0765	amino acid transport
NN994_RS07290	COG1181	Belongs to the D-alanine--D-alanine ligase family
NN994_RS07300	COG2217	Heavy metal translocating P-type atpase
NN994_RS07310	COG0159	tryptophan synthase activity
NN994_RS07320	COG0135	phosphoribosylanthranilate isomerase activity
NN994_RS07335	COG0512	Glutamine amidotransferase of anthranilate synthase
NN994_RS07340	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NN994_RS07345	COG1605	Chorismate mutase
NN994_RS07345	COG0287	Prephenate dehydrogenase
NN994_RS07355	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NN994_RS07380	COG2176	DNA-directed DNA polymerase activity
NN994_RS07390	COG2151	metal-sulfur cluster biosynthetic enzyme
NN994_RS07400	COG2081	HI0933 family
NN994_RS07425	COG1131	(ABC) transporter
NN994_RS07430	COG0537	adenosine 5'-monophosphoramidase activity
NN994_RS07465	COG2226	methyltransferase
NN994_RS07470	COG0799	negative regulation of ribosome biogenesis
NN994_RS07475	COG1713	HD superfamily hydrolase involved in NAD metabolism
NN994_RS07480	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NN994_RS07485	COG1534	Rna-binding protein
NN994_RS07490	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NN994_RS07495	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
NN994_RS07550	COG1335	isochorismatase
NN994_RS07560	COG0436	Aminotransferase
NN994_RS07565	COG0589	response to stress
NN994_RS07585	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NN994_RS07595	COG1253	flavin adenine dinucleotide binding
NN994_RS07600	COG1119	ATPase activity
NN994_RS07605	COG0025	NhaP-type Na H and K H
NN994_RS07615	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
NN994_RS07620	COG1242	4 iron, 4 sulfur cluster binding
NN994_RS07625	COG3480	Lon protease (S16) C-terminal proteolytic domain
NN994_RS07630	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NN994_RS07640	COG0492	ferredoxin-NADP+ reductase activity
NN994_RS07650	COG1126	abc transporter atp-binding protein
NN994_RS07660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NN994_RS07675	COG1882	Formate acetyltransferase
NN994_RS07700	COG0390	transport system, permease component
NN994_RS07705	COG4619	ABC transporter
NN994_RS07710	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NN994_RS07725	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NN994_RS07790	COG3290	protein histidine kinase activity
NN994_RS07800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NN994_RS07805	COG2274	protein secretion by the type I secretion system
NN994_RS07810	COG1132	(ABC) transporter
NN994_RS07815	COG1132	(ABC) transporter
NN994_RS07830	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NN994_RS07835	COG4470	Protein conserved in bacteria
NN994_RS07840	COG0737	Belongs to the 5'-nucleotidase family
NN994_RS07845	COG0513	Belongs to the DEAD box helicase family
NN994_RS07855	COG0768	penicillin binding
NN994_RS07885	COG3152	Membrane
NN994_RS07895	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NN994_RS07910	COG4152	abc transporter atp-binding protein
NN994_RS07915	COG1811	Na channel or pump
NN994_RS07925	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
NN994_RS07955	COG0561	phosphatase activity
NN994_RS07960	COG0252	asparaginase activity
NN994_RS07970	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NN994_RS07985	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NN994_RS07990	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NN994_RS08005	COG1482	cell wall glycoprotein biosynthetic process
NN994_RS08010	COG1940	carbohydrate kinase activity
NN994_RS08015	COG1263	PTS System
NN994_RS08015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NN994_RS08015	COG2190	(PTS) system
NN994_RS08020	COG1621	beta-fructofuranosidase activity
NN994_RS08025	COG1609	Transcriptional regulator
NN994_RS08040	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NN994_RS08045	COG2131	deaminase
NN994_RS08050	COG0006	proline dipeptidase activity
NN994_RS08065	COG1131	(ABC) transporter
NN994_RS08140	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NN994_RS08140	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NN994_RS08165	COG0681	Belongs to the peptidase S26 family
NN994_RS08170	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NN994_RS08180	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
NN994_RS08190	COG0456	acetyltransferase
NN994_RS08195	COG1214	PFAM Peptidase M22, glycoprotease
NN994_RS08215	COG0174	glutamine synthetase
NN994_RS08220	COG0789	Transcriptional regulator
NN994_RS08275	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NN994_RS08320	COG0084	hydrolase, TatD family'
NN994_RS08325	COG1832	CoA-binding protein
NN994_RS08330	COG3118	belongs to the thioredoxin family
NN994_RS08405	COG0706	membrane insertase activity
NN994_RS08465	COG0756	dUTP diphosphatase activity
NN994_RS08495	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NN994_RS08500	COG0705	Rhomboid family
NN994_RS08500	COG0457	Tetratricopeptide repeat
NN994_RS08505	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NN994_RS08520	COG0647	UMP catabolic process
NN994_RS08530	COG2226	methyltransferase
NN994_RS08560	COG0425	Belongs to the sulfur carrier protein TusA family
NN994_RS08565	COG2391	methyltransferase activity
NN994_RS08570	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NN994_RS08575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NN994_RS08585	COG1363	Peptidase, m42
NN994_RS08590	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NN994_RS08595	COG1266	CAAX protease self-immunity
NN994_RS08655	COG1459	type II secretion system
NN994_RS08660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NN994_RS08695	COG0440	acetolactate synthase activity
NN994_RS08700	COG0028	Belongs to the TPP enzyme family
NN994_RS08710	COG1461	Dihydroxyacetone kinase
NN994_RS08720	COG0534	Mate efflux family protein
NN994_RS08735	COG3590	peptidase
NN994_RS08755	COG4475	Protein of unknown function (DUF436)
NN994_RS08780	COG0191	fructose-bisphosphate aldolase activity
NN994_RS08840	COG0201	protein transport
NN994_RS08995	COG1132	(ABC) transporter
NN994_RS09030	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NN994_RS09075	COG0602	queuosine metabolic process
NN994_RS09085	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NN994_RS09115	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NN994_RS09140	COG2261	transglycosylase associated protein
NN994_RS09160	COG3237	CsbD-like
NN994_RS09210	COG1511	domain protein
NN994_RS09210	COG1511	domain protein
NN994_RS09220	COG3759	membrane
NN994_RS09240	COG0305	Participates in initiation and elongation during chromosome replication
NN994_RS09260	COG0494	nUDIX hydrolase
NN994_RS09275	COG0741	lytic transglycosylase activity
NN994_RS09280	COG1388	LysM domain
NN994_RS09280	COG3584	3D domain protein
NN994_RS09285	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NN994_RS09300	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NN994_RS09310	COG0612	Peptidase, M16
NN994_RS09340	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NN994_RS09345	COG0488	(ABC) transporter
NN994_RS09380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NN994_RS09385	COG1475	DNA binding