locus-tag	class	description
EKD16_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EKD16_RS00010	COG0592	DNA-directed DNA polymerase activity
EKD16_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EKD16_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EKD16_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
EKD16_RS00030	COG0187	DNA topoisomerase II activity
EKD16_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EKD16_RS00080	COG1518	maintenance of DNA repeat elements
EKD16_RS00150	COG2030	dehydratase
EKD16_RS00150	COG1012	belongs to the aldehyde dehydrogenase family
EKD16_RS00155	COG3396	Phenylacetate-CoA oxygenase
EKD16_RS00160	COG3460	Phenylacetate-CoA oxygenase
EKD16_RS00165	COG3396	Phenylacetate-CoA oxygenase
EKD16_RS00170	COG2151	metal-sulfur cluster biosynthetic enzyme
EKD16_RS00175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EKD16_RS00180	COG1472	Belongs to the glycosyl hydrolase 3 family
EKD16_RS00235	COG0655	NAD(P)H dehydrogenase (quinone) activity
EKD16_RS00270	COG2076	Multidrug Resistance protein
EKD16_RS00290	COG2076	Multidrug Resistance protein
EKD16_RS00295	COG0590	tRNA wobble adenosine to inosine editing
EKD16_RS00330	COG0705	Rhomboid family
EKD16_RS00340	COG0515	serine threonine protein kinase
EKD16_RS00345	COG0515	serine threonine protein kinase
EKD16_RS00350	COG0768	penicillin binding
EKD16_RS00365	COG1716	ATPase activity
EKD16_RS00380	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EKD16_RS00430	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EKD16_RS00440	COG1063	alcohol dehydrogenase
EKD16_RS00460	COG0583	DNA-binding transcription factor activity
EKD16_RS00470	COG0583	DNA-binding transcription factor activity
EKD16_RS00505	COG0592	DNA-directed DNA polymerase activity
EKD16_RS00570	COG3629	intracellular signal transduction
EKD16_RS00570	COG3903	Transcriptional regulator
EKD16_RS00695	COG1408	metallophosphoesterase
EKD16_RS00705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EKD16_RS00715	COG0003	Pfam Anion-transporting ATPase
EKD16_RS00740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EKD16_RS00755	COG0494	nUDIX hydrolase
EKD16_RS00770	COG1366	Belongs to the anti-sigma-factor antagonist family
EKD16_RS00775	COG1111	helicase
EKD16_RS00775	COG1205	dead DEAH box helicase
EKD16_RS00835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EKD16_RS00845	COG0596	Alpha beta hydrolase
EKD16_RS00855	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
EKD16_RS00860	COG2062	phosphohistidine phosphatase, SixA
EKD16_RS00890	COG3830	Belongs to the UPF0237 family
EKD16_RS00890	COG0560	Phosphoserine phosphatase
EKD16_RS00910	COG1119	ATPase activity
EKD16_RS00935	COG0446	pyridine nucleotide-disulphide oxidoreductase
EKD16_RS00945	COG1309	transcriptional regulator
EKD16_RS00950	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EKD16_RS00985	COG0110	maltose O-acetyltransferase activity
EKD16_RS01005	COG3963	phosphatidate phosphatase activity
EKD16_RS01010	COG1028	Short-chain dehydrogenase reductase Sdr
EKD16_RS01015	COG0140	phosphoribosyl-ATP diphosphatase activity
EKD16_RS01020	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EKD16_RS01030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EKD16_RS01045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EKD16_RS01100	COG0740	serine-type endopeptidase activity
EKD16_RS01105	COG0740	serine-type endopeptidase activity
EKD16_RS01115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EKD16_RS01120	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EKD16_RS01125	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EKD16_RS01130	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EKD16_RS01140	COG1012	belongs to the aldehyde dehydrogenase family
EKD16_RS01160	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EKD16_RS01170	COG0047	phosphoribosylformylglycinamidine synthase activity
EKD16_RS01180	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EKD16_RS01185	COG1595	DNA-templated transcription, initiation
EKD16_RS01195	COG0022	dehydrogenase e1 component
EKD16_RS01200	COG0508	dehydrogenase complex catalyzes the overall conversion of
EKD16_RS01250	COG1064	alcohol dehydrogenase
EKD16_RS01255	COG1309	transcriptional regulator
EKD16_RS01295	COG2255	four-way junction helicase activity
EKD16_RS01300	COG1960	acyl-CoA dehydrogenase activity
EKD16_RS01320	COG0542	response to heat
EKD16_RS01325	COG0789	Transcriptional regulator
EKD16_RS01330	COG0484	heat shock protein binding
EKD16_RS01335	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EKD16_RS01340	COG0443	Heat shock 70 kDa protein
EKD16_RS01345	COG2181	nitrate reductase activity
EKD16_RS01345	COG0247	lactate metabolic process
EKD16_RS01415	COG0706	membrane insertase activity
EKD16_RS01435	COG0471	metal ion transport
EKD16_RS01440	COG1739	Uncharacterized protein family UPF0029
EKD16_RS01465	COG1366	Belongs to the anti-sigma-factor antagonist family
EKD16_RS01495	COG1309	transcriptional regulator
EKD16_RS01515	COG0860	N-Acetylmuramoyl-L-alanine amidase
EKD16_RS01550	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EKD16_RS01565	COG1392	Phosphate transport regulator
EKD16_RS01570	COG0306	phosphate transporter
EKD16_RS01575	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EKD16_RS01595	COG0456	acetyltransferase
EKD16_RS01605	COG0745	RESPONSE REGULATOR receiver
EKD16_RS01620	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EKD16_RS01625	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EKD16_RS01630	COG0181	hydroxymethylbilane synthase activity
EKD16_RS01635	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EKD16_RS01635	COG1648	precorrin-2 dehydrogenase activity
EKD16_RS01640	COG0113	porphobilinogen synthase activity
EKD16_RS01660	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EKD16_RS01685	COG0673	inositol 2-dehydrogenase activity
EKD16_RS01690	COG1175	transmembrane transport
EKD16_RS01695	COG0395	ABC-type sugar transport system, permease component
EKD16_RS01700	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EKD16_RS01705	COG0406	alpha-ribazole phosphatase activity
EKD16_RS01720	COG0560	Phosphoserine phosphatase
EKD16_RS01765	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EKD16_RS01770	COG3442	glutamine amidotransferase
EKD16_RS01785	COG3485	protocatechuate 3,4-dioxygenase
EKD16_RS01810	COG0588	phosphoglycerate mutase activity
EKD16_RS01820	COG0438	transferase activity, transferring glycosyl groups
EKD16_RS01830	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
EKD16_RS01870	COG1490	D-aminoacyl-tRNA deacylase activity
EKD16_RS01880	COG5002	protein histidine kinase activity
EKD16_RS01895	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EKD16_RS01905	COG0215	cysteine-tRNA ligase activity
EKD16_RS01910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EKD16_RS02010	COG1674	ftsk spoiiie
EKD16_RS02020	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EKD16_RS02105	COG1309	transcriptional regulator
EKD16_RS02110	COG0667	Aldo Keto reductase
EKD16_RS02125	COG1404	Belongs to the peptidase S8 family
EKD16_RS02130	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EKD16_RS02140	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EKD16_RS02150	COG0459	protein refolding
EKD16_RS02160	COG0583	DNA-binding transcription factor activity
EKD16_RS02165	COG2259	Doxx family
EKD16_RS02170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EKD16_RS02180	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EKD16_RS02190	COG1061	Type III restriction enzyme res subunit
EKD16_RS02225	COG1278	Cold shock
EKD16_RS02245	COG2890	protein-(glutamine-N5) methyltransferase activity
EKD16_RS02255	COG2252	PERMEase
EKD16_RS02260	COG1846	Transcriptional regulator
EKD16_RS02270	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EKD16_RS02285	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
EKD16_RS02315	COG0259	pyridoxamine-phosphate oxidase activity
EKD16_RS02330	COG1960	acyl-CoA dehydrogenase activity
EKD16_RS02335	COG0183	Belongs to the thiolase family
EKD16_RS02360	COG2205	protein histidine kinase activity
EKD16_RS02365	COG0745	RESPONSE REGULATOR receiver
EKD16_RS02375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EKD16_RS02380	COG2353	YceI-like domain
EKD16_RS02390	COG0018	arginyl-trna synthetase
EKD16_RS02395	COG0416	fatty acid biosynthetic process
EKD16_RS02410	COG1940	carbohydrate kinase activity
EKD16_RS02420	COG1024	Enoyl-CoA hydratase
EKD16_RS02450	COG4585	Histidine kinase
EKD16_RS02455	COG2197	response regulator
EKD16_RS02465	COG3437	response regulator, receiver
EKD16_RS02465	COG3850	Histidine kinase
EKD16_RS02465	COG4999	Histidine kinase
EKD16_RS02465	COG2205	protein histidine kinase activity
EKD16_RS02485	COG1309	transcriptional regulator
EKD16_RS02490	COG0667	Aldo Keto reductase
EKD16_RS02495	COG2130	NADP-dependent
EKD16_RS02520	COG0438	transferase activity, transferring glycosyl groups
EKD16_RS02530	COG0631	protein serine/threonine phosphatase activity
EKD16_RS02550	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EKD16_RS02555	COG1917	Cupin 2, conserved barrel domain protein
EKD16_RS02560	COG5285	phytanoyl-CoA dioxygenase
EKD16_RS02565	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EKD16_RS02570	COG0765	amino acid transport
EKD16_RS02575	COG0765	amino acid transport
EKD16_RS02580	COG1126	abc transporter atp-binding protein
EKD16_RS02590	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EKD16_RS02595	COG0406	alpha-ribazole phosphatase activity
EKD16_RS02595	COG0494	nUDIX hydrolase
EKD16_RS02605	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EKD16_RS02610	COG0802	atpase or kinase
EKD16_RS02625	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EKD16_RS02645	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EKD16_RS02650	COG0459	protein refolding
EKD16_RS02655	COG1595	DNA-templated transcription, initiation
EKD16_RS02665	COG0516	GMP reductase activity
EKD16_RS02675	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EKD16_RS02685	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EKD16_RS02725	COG0515	serine threonine protein kinase
EKD16_RS02725	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EKD16_RS02735	COG1120	ATPase activity
EKD16_RS02740	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EKD16_RS02745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EKD16_RS02755	COG2301	Belongs to the HpcH HpaI aldolase family
EKD16_RS02760	COG1846	Transcriptional regulator
EKD16_RS02760	COG0456	acetyltransferase
EKD16_RS02770	COG0745	RESPONSE REGULATOR receiver
EKD16_RS02775	COG2205	protein histidine kinase activity
EKD16_RS02785	COG0438	transferase activity, transferring glycosyl groups
EKD16_RS02790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EKD16_RS02830	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EKD16_RS02830	COG0519	Catalyzes the synthesis of GMP from XMP
EKD16_RS02845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EKD16_RS02860	COG4585	Histidine kinase
EKD16_RS02865	COG2197	response regulator
EKD16_RS02900	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EKD16_RS02925	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EKD16_RS02925	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EKD16_RS02930	COG0045	succinate-CoA ligase (ADP-forming) activity
EKD16_RS02955	COG0138	bifunctional purine biosynthesis protein purh
EKD16_RS02960	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EKD16_RS02980	COG1316	TRANSCRIPTIONal
EKD16_RS02985	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EKD16_RS02990	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EKD16_RS03005	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
EKD16_RS03010	COG1473	amidohydrolase
EKD16_RS03010	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
EKD16_RS03015	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EKD16_RS03055	COG1823	symporter activity
EKD16_RS03065	COG4770	biotin carboxylase activity
EKD16_RS03075	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EKD16_RS03080	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EKD16_RS03095	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
EKD16_RS03110	COG0745	RESPONSE REGULATOR receiver
EKD16_RS03115	COG5002	protein histidine kinase activity
EKD16_RS03120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EKD16_RS03125	COG0586	Pfam SNARE associated Golgi protein
EKD16_RS03140	COG1832	CoA-binding protein
EKD16_RS03145	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EKD16_RS03160	COG1316	TRANSCRIPTIONal
EKD16_RS03175	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EKD16_RS03220	COG0438	transferase activity, transferring glycosyl groups
EKD16_RS03250	COG1316	TRANSCRIPTIONal
EKD16_RS03265	COG0463	Glycosyl transferase, family 2
EKD16_RS03305	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
EKD16_RS03325	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EKD16_RS03335	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EKD16_RS03355	COG1331	Highly conserved protein containing a thioredoxin domain
EKD16_RS03360	COG2815	serine threonine protein kinase
EKD16_RS03360	COG0515	serine threonine protein kinase
EKD16_RS03370	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EKD16_RS03375	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EKD16_RS03395	COG0114	fumarate hydratase activity
EKD16_RS03430	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EKD16_RS03455	COG2188	Transcriptional regulator
EKD16_RS03460	COG1570	exodeoxyribonuclease VII activity
EKD16_RS03465	COG1722	exodeoxyribonuclease VII activity
EKD16_RS03475	COG1322	Protein conserved in bacteria
EKD16_RS03490	COG0012	GTP binding
EKD16_RS03505	COG3654	unkown
EKD16_RS03560	COG1192	Involved in chromosome partitioning
EKD16_RS03580	COG2188	Transcriptional regulator
EKD16_RS03585	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EKD16_RS03600	COG0494	nUDIX hydrolase
EKD16_RS03605	COG1217	gtp-binding protein TYPA
EKD16_RS03635	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EKD16_RS03645	COG1053	succinate dehydrogenase
EKD16_RS03665	COG1053	succinate dehydrogenase
EKD16_RS03670	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EKD16_RS03700	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EKD16_RS03710	COG1994	Peptidase M50
EKD16_RS03745	COG2171	N-acyltransferase activity
EKD16_RS03750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EKD16_RS03755	COG1611	Belongs to the LOG family
EKD16_RS03770	COG2818	Glycosylase
EKD16_RS03785	COG1024	Enoyl-CoA hydratase
EKD16_RS03795	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EKD16_RS03800	COG4122	O-methyltransferase activity
EKD16_RS03805	COG1595	DNA-templated transcription, initiation
EKD16_RS03820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EKD16_RS03845	COG0613	PHP domain protein
EKD16_RS03850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EKD16_RS03860	COG0513	Belongs to the DEAD box helicase family
EKD16_RS03880	COG0668	transmembrane transport
EKD16_RS03915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EKD16_RS03940	COG1028	Short-chain dehydrogenase reductase Sdr
EKD16_RS03940	COG3321	synthase
EKD16_RS03940	COG0604	alcohol dehydrogenase
EKD16_RS03990	COG2197	response regulator
EKD16_RS04000	COG0210	DNA helicase
EKD16_RS04010	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EKD16_RS04030	COG2197	response regulator
EKD16_RS04040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EKD16_RS04065	COG1946	Acyl-CoA thioesterase
EKD16_RS04095	COG0314	molybdopterin synthase activity
EKD16_RS04110	COG1615	UPF0182 protein
EKD16_RS04130	COG0483	inositol monophosphate 1-phosphatase activity
EKD16_RS04150	COG1162	GTPase activity
EKD16_RS04155	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EKD16_RS04165	COG2135	peptidase activity
EKD16_RS04170	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EKD16_RS04180	COG1595	DNA-templated transcription, initiation
EKD16_RS04185	COG5662	AntiSigma factor
EKD16_RS04190	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EKD16_RS04190	COG2199	diguanylate cyclase activity
EKD16_RS04200	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EKD16_RS04215	COG2188	Transcriptional regulator
EKD16_RS04245	COG2172	sigma factor antagonist activity
EKD16_RS04260	COG0765	amino acid transport
EKD16_RS04265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EKD16_RS04270	COG0281	malic enzyme
EKD16_RS04290	COG0604	alcohol dehydrogenase
EKD16_RS04305	COG0508	dehydrogenase complex catalyzes the overall conversion of
EKD16_RS04305	COG0567	Dehydrogenase, E1 component
EKD16_RS04310	COG1028	Short-chain dehydrogenase reductase Sdr
EKD16_RS04330	COG0612	Peptidase, M16
EKD16_RS04345	COG2814	Major facilitator Superfamily
EKD16_RS04390	COG1595	DNA-templated transcription, initiation
EKD16_RS04440	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
EKD16_RS04440	COG0778	Nitroreductase
EKD16_RS04445	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EKD16_RS04490	COG2835	tetraacyldisaccharide 4'-kinase activity
EKD16_RS04510	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EKD16_RS04510	COG2755	lipolytic protein G-D-S-L family
EKD16_RS04520	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EKD16_RS04525	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EKD16_RS04545	COG0714	Associated with various cellular activities
EKD16_RS04565	COG0745	RESPONSE REGULATOR receiver
EKD16_RS04570	COG5002	protein histidine kinase activity
EKD16_RS04570	COG5000	phosphorelay sensor kinase activity
EKD16_RS04575	COG5401	PFAM Sporulation and spore germination
EKD16_RS04585	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EKD16_RS04595	COG0653	protein targeting
EKD16_RS04600	COG1263	PTS System
EKD16_RS04605	COG2188	Transcriptional regulator
EKD16_RS04615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EKD16_RS04630	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EKD16_RS04635	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EKD16_RS04640	COG1472	Belongs to the glycosyl hydrolase 3 family
EKD16_RS04650	COG1011	Hydrolase
EKD16_RS04660	COG1012	belongs to the aldehyde dehydrogenase family
EKD16_RS04675	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EKD16_RS04680	COG2884	Cell division ATP-binding protein ftsE
EKD16_RS04690	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EKD16_RS04695	COG0768	penicillin binding
EKD16_RS04710	COG1215	transferase activity, transferring glycosyl groups
EKD16_RS04715	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EKD16_RS04750	COG4981	capsule polysaccharide biosynthetic process
EKD16_RS04765	COG0500	methyltransferase
EKD16_RS04770	COG2226	methyltransferase
EKD16_RS04805	COG0300	oxidoreductase activity
EKD16_RS04820	COG2018	Roadblock/LC7 domain
EKD16_RS04845	COG1473	amidohydrolase
EKD16_RS04855	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EKD16_RS04885	COG0242	peptide deformylase activity
EKD16_RS04930	COG1024	Enoyl-CoA hydratase
EKD16_RS04955	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EKD16_RS04960	COG0702	epimerase
EKD16_RS04980	COG3119	arylsulfatase activity
EKD16_RS04985	COG0477	Major facilitator Superfamily
EKD16_RS04990	COG1609	Transcriptional regulator
EKD16_RS05025	COG0318	PFAM AMP-dependent synthetase and ligase
EKD16_RS05030	COG0318	PFAM AMP-dependent synthetase and ligase
EKD16_RS05040	COG0745	RESPONSE REGULATOR receiver
EKD16_RS05050	COG0019	diaminopimelate decarboxylase activity
EKD16_RS05055	COG0460	homoserine dehydrogenase
EKD16_RS05060	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EKD16_RS05065	COG0083	homoserine kinase activity
EKD16_RS05075	COG0254	rRNA binding
EKD16_RS05080	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EKD16_RS05085	COG2890	protein-(glutamine-N5) methyltransferase activity
EKD16_RS05095	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EKD16_RS05110	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EKD16_RS05115	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EKD16_RS05120	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EKD16_RS05125	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EKD16_RS05130	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EKD16_RS05135	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EKD16_RS05140	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EKD16_RS05165	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
EKD16_RS05175	COG1250	3-hydroxyacyl-CoA dehydrogenase
EKD16_RS05200	COG0183	Belongs to the thiolase family
EKD16_RS05240	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EKD16_RS05240	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EKD16_RS05260	COG1678	Uncharacterized ACR, COG1678
EKD16_RS05295	COG1335	isochorismatase
EKD16_RS05305	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EKD16_RS05345	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EKD16_RS05350	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EKD16_RS05370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EKD16_RS05410	COG2226	methyltransferase
EKD16_RS05415	COG0438	transferase activity, transferring glycosyl groups
EKD16_RS05425	COG1309	transcriptional regulator
EKD16_RS05435	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EKD16_RS05450	COG0517	IMP dehydrogenase activity
EKD16_RS05450	COG1125	glycine betaine transport
EKD16_RS05455	COG1174	glycine betaine transport
EKD16_RS05460	COG1174	glycine betaine transport
EKD16_RS05475	COG0616	signal peptide processing
EKD16_RS05485	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EKD16_RS05500	COG0366	Alpha amylase catalytic
EKD16_RS05505	COG0058	SHG alpha-glucan phosphorylase activity
EKD16_RS05515	COG3655	Transcriptional regulator
EKD16_RS05550	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EKD16_RS05550	COG0515	serine threonine protein kinase
EKD16_RS05560	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EKD16_RS05575	COG0482	sulfurtransferase activity
EKD16_RS05590	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EKD16_RS05600	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EKD16_RS05605	COG0154	amidase activity
EKD16_RS05620	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EKD16_RS05635	COG0440	acetolactate synthase activity
EKD16_RS05640	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EKD16_RS05650	COG0473	3-isopropylmalate dehydrogenase activity
EKD16_RS05655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EKD16_RS05660	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EKD16_RS05670	COG0179	Fumarylacetoacetate (FAA) hydrolase
EKD16_RS05685	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EKD16_RS05715	COG2133	pyrroloquinoline quinone binding
EKD16_RS05725	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EKD16_RS05730	COG0066	3-isopropylmalate dehydratase activity
EKD16_RS05740	COG1920	GTP binding
EKD16_RS05750	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EKD16_RS05760	COG1181	Belongs to the D-alanine--D-alanine ligase family
EKD16_RS05795	COG3629	intracellular signal transduction
EKD16_RS05795	COG3903	Transcriptional regulator
EKD16_RS05815	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EKD16_RS05820	COG1737	Transcriptional regulator
EKD16_RS05870	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EKD16_RS05875	COG1414	Transcriptional regulator
EKD16_RS05885	COG1012	belongs to the aldehyde dehydrogenase family
EKD16_RS05890	COG4948	Mandelate Racemase Muconate Lactonizing
EKD16_RS05900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EKD16_RS05905	COG0747	negative chemotaxis
EKD16_RS05910	COG0444	Belongs to the ABC transporter superfamily
EKD16_RS05940	COG0445	tRNA wobble uridine modification
EKD16_RS05945	COG1414	Transcriptional regulator
EKD16_RS05955	COG0601	transmembrane transport
EKD16_RS05960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EKD16_RS05970	COG4608	Belongs to the ABC transporter superfamily
EKD16_RS05975	COG0747	negative chemotaxis
EKD16_RS05995	COG3903	Transcriptional regulator
EKD16_RS05995	COG3629	intracellular signal transduction
EKD16_RS06020	COG0443	Heat shock 70 kDa protein
EKD16_RS06060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EKD16_RS06120	COG2226	methyltransferase
EKD16_RS06125	COG2124	cytochrome p450
EKD16_RS06135	COG1846	Transcriptional regulator
EKD16_RS06150	COG2197	response regulator
EKD16_RS06155	COG4585	Histidine kinase
EKD16_RS06160	COG0577	efflux transmembrane transporter activity
EKD16_RS06160	COG1136	(ABC) transporter
EKD16_RS06175	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EKD16_RS06200	COG1132	(ABC) transporter
EKD16_RS06205	COG1136	(ABC) transporter
EKD16_RS06205	COG0577	efflux transmembrane transporter activity
EKD16_RS06210	COG0577	efflux transmembrane transporter activity
EKD16_RS06210	COG1136	(ABC) transporter
EKD16_RS06230	COG2124	cytochrome p450
EKD16_RS06240	COG3629	intracellular signal transduction
EKD16_RS06240	COG3903	Transcriptional regulator
EKD16_RS06280	COG1595	DNA-templated transcription, initiation
EKD16_RS06300	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EKD16_RS06305	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EKD16_RS06340	COG2124	cytochrome p450
EKD16_RS06360	COG0693	protein deglycase activity
EKD16_RS06370	COG0438	transferase activity, transferring glycosyl groups
EKD16_RS06390	COG2271	Major facilitator Superfamily
EKD16_RS06395	COG1461	Dihydroxyacetone kinase
EKD16_RS06400	COG2376	Dihydroxyacetone kinase
EKD16_RS06410	COG1643	Atp-dependent helicase
EKD16_RS06415	COG2706	6-phosphogluconolactonase activity
EKD16_RS06430	COG1268	BioY protein
EKD16_RS06435	COG1122	ATPase activity
EKD16_RS06455	COG1960	acyl-CoA dehydrogenase activity
EKD16_RS06460	COG1960	acyl-CoA dehydrogenase activity
EKD16_RS06480	COG0584	glycerophosphoryl diester phosphodiesterase
EKD16_RS06510	COG0569	domain protein
EKD16_RS06515	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EKD16_RS06520	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EKD16_RS06535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EKD16_RS06550	COG0667	Aldo Keto reductase
EKD16_RS06590	COG2188	Transcriptional regulator
EKD16_RS06625	COG0791	NLP P60 protein
EKD16_RS06670	COG2894	cell division
EKD16_RS06695	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EKD16_RS06730	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EKD16_RS06760	COG0668	transmembrane transport
EKD16_RS06765	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EKD16_RS06780	COG0438	transferase activity, transferring glycosyl groups
EKD16_RS06795	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EKD16_RS06810	COG1115	amino acid carrier protein
EKD16_RS06830	COG0318	PFAM AMP-dependent synthetase and ligase
EKD16_RS06835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EKD16_RS06845	COG0156	8-amino-7-oxononanoate synthase activity
EKD16_RS06850	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EKD16_RS06855	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EKD16_RS06860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EKD16_RS06885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EKD16_RS06900	COG1309	transcriptional regulator
EKD16_RS06915	COG1012	belongs to the aldehyde dehydrogenase family
EKD16_RS06920	COG1012	belongs to the aldehyde dehydrogenase family
EKD16_RS06935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EKD16_RS06950	COG1079	Belongs to the binding-protein-dependent transport system permease family
EKD16_RS06955	COG4603	Belongs to the binding-protein-dependent transport system permease family
EKD16_RS06960	COG3845	ABC transporter
EKD16_RS06965	COG1744	ABC transporter substrate-binding protein PnrA-like
EKD16_RS06970	COG2267	carboxylic ester hydrolase activity
EKD16_RS06975	COG0508	dehydrogenase complex catalyzes the overall conversion of
EKD16_RS06980	COG0022	dehydrogenase e1 component
EKD16_RS06995	COG1522	sequence-specific DNA binding
EKD16_RS07020	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EKD16_RS07025	COG0121	glutamine amidotransferase
EKD16_RS07030	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
EKD16_RS07035	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EKD16_RS07045	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EKD16_RS07055	COG1575	Belongs to the MenA family. Type 1 subfamily
EKD16_RS07060	COG1247	-acetyltransferase
EKD16_RS07065	COG1950	PFAM Membrane protein of
EKD16_RS07070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EKD16_RS07075	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EKD16_RS07080	COG1674	ftsk spoiiie
EKD16_RS07090	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EKD16_RS07100	COG1058	Belongs to the CinA family
EKD16_RS07100	COG1546	Belongs to the CinA family
EKD16_RS07105	COG1396	sequence-specific DNA binding
EKD16_RS07110	COG0783	Belongs to the Dps family
EKD16_RS07120	COG1472	Belongs to the glycosyl hydrolase 3 family
EKD16_RS07125	COG0395	ABC-type sugar transport system, permease component
EKD16_RS07155	COG1201	RNA secondary structure unwinding
EKD16_RS07165	COG1372	Participates in initiation and elongation during chromosome replication
EKD16_RS07165	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EKD16_RS07165	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EKD16_RS07165	COG1372	Participates in initiation and elongation during chromosome replication
EKD16_RS07170	COG2137	regulation of response to DNA damage stimulus
EKD16_RS07180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EKD16_RS07185	COG1505	serine-type exopeptidase activity
EKD16_RS07190	COG2358	TRAP transporter, solute receptor (TAXI family
EKD16_RS07205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EKD16_RS07210	COG2124	cytochrome p450
EKD16_RS07215	COG1309	transcriptional regulator
EKD16_RS07230	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EKD16_RS07235	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EKD16_RS07255	COG0247	lactate metabolic process
EKD16_RS07260	COG0277	FAD linked oxidase domain protein
EKD16_RS07265	COG0277	FAD linked oxidase domain protein
EKD16_RS07270	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EKD16_RS07275	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EKD16_RS07285	COG0456	acetyltransferase
EKD16_RS07300	COG1596	polysaccharide export
EKD16_RS07300	COG1555	photosystem II stabilization
EKD16_RS07310	COG0268	Binds directly to 16S ribosomal RNA
EKD16_RS07320	COG0481	GTPase activity
EKD16_RS07330	COG0366	Alpha amylase catalytic
EKD16_RS07365	COG1420	regulation of RNA biosynthetic process
EKD16_RS07370	COG0484	heat shock protein binding
EKD16_RS07390	COG0537	adenosine 5'-monophosphoramidase activity
EKD16_RS07400	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EKD16_RS07415	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EKD16_RS07420	COG1414	Transcriptional regulator
EKD16_RS07425	COG3622	Belongs to the hyi family
EKD16_RS07430	COG2084	Dehydrogenase
EKD16_RS07435	COG3960	tartronate-semialdehyde synthase activity
EKD16_RS07440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EKD16_RS07445	COG2340	Cysteine-rich secretory protein family
EKD16_RS07450	COG1381	Involved in DNA repair and RecF pathway recombination
EKD16_RS07455	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EKD16_RS07475	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EKD16_RS07480	COG1121	(ABC) transporter
EKD16_RS07490	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EKD16_RS07500	COG0423	glycine-tRNA ligase activity
EKD16_RS07505	COG1272	protein, Hemolysin III
EKD16_RS07520	COG0574	Belongs to the PEP-utilizing enzyme family
EKD16_RS07520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EKD16_RS07530	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EKD16_RS07535	COG2890	protein-(glutamine-N5) methyltransferase activity
EKD16_RS07545	COG1609	Transcriptional regulator
EKD16_RS07570	COG1175	transmembrane transport
EKD16_RS07575	COG0395	ABC-type sugar transport system, permease component
EKD16_RS07595	COG4214	carbohydrate transport
EKD16_RS07600	COG0358	DNA primase activity
EKD16_RS07605	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EKD16_RS07625	COG0277	FAD linked oxidase domain protein
EKD16_RS07625	COG0247	lactate metabolic process
EKD16_RS07675	COG1250	3-hydroxyacyl-CoA dehydrogenase
EKD16_RS07680	COG3246	L-lysine catabolic process to acetate
EKD16_RS07695	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EKD16_RS07700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EKD16_RS07710	COG3485	protocatechuate 3,4-dioxygenase
EKD16_RS07715	COG3485	protocatechuate 3,4-dioxygenase
EKD16_RS07720	COG0183	Belongs to the thiolase family
EKD16_RS07725	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EKD16_RS07730	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EKD16_RS07735	COG1414	Transcriptional regulator
EKD16_RS07740	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EKD16_RS07750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EKD16_RS07755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EKD16_RS07760	COG1116	anion transmembrane transporter activity
EKD16_RS07795	COG3458	cephalosporin-C deacetylase activity
EKD16_RS07800	COG0039	L-malate dehydrogenase activity
EKD16_RS08245	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
EKD16_RS08250	COG0142	geranyltranstransferase activity
EKD16_RS08270	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
EKD16_RS08290	COG3046	protein related to deoxyribodipyrimidine photolyase
EKD16_RS08295	COG0733	neurotransmitter:sodium symporter activity
EKD16_RS08345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EKD16_RS08360	COG1028	Short-chain dehydrogenase reductase Sdr
EKD16_RS08370	COG1028	Short-chain dehydrogenase reductase Sdr
EKD16_RS08380	COG2814	Major facilitator Superfamily
EKD16_RS08405	COG1695	Transcriptional regulator
EKD16_RS08415	COG2226	methyltransferase
EKD16_RS08420	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EKD16_RS08450	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EKD16_RS08490	COG1028	Short-chain dehydrogenase reductase Sdr
EKD16_RS08505	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
EKD16_RS08510	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EKD16_RS08520	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EKD16_RS08560	COG0298	carbon dioxide binding
EKD16_RS08565	COG0409	Hydrogenase expression formation protein
EKD16_RS08575	COG0375	protein maturation
EKD16_RS08590	COG2890	protein-(glutamine-N5) methyltransferase activity
EKD16_RS08595	COG2318	DinB family
EKD16_RS08630	COG1134	teichoic acid transport
EKD16_RS08635	COG2130	NADP-dependent
EKD16_RS08685	COG0513	Belongs to the DEAD box helicase family
EKD16_RS08690	COG0583	DNA-binding transcription factor activity
EKD16_RS08700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EKD16_RS08720	COG2273	Hydrolase Family 16
EKD16_RS08735	COG1172	Belongs to the binding-protein-dependent transport system permease family
EKD16_RS08740	COG1172	Belongs to the binding-protein-dependent transport system permease family
EKD16_RS08755	COG1940	carbohydrate kinase activity
EKD16_RS08755	COG1846	Transcriptional regulator
EKD16_RS08780	COG1063	alcohol dehydrogenase
EKD16_RS08800	COG1028	Short-chain dehydrogenase reductase Sdr
EKD16_RS08855	COG1609	Transcriptional regulator
EKD16_RS08875	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EKD16_RS08890	COG0517	IMP dehydrogenase activity
EKD16_RS08890	COG4175	Glycine betaine
EKD16_RS08895	COG4176	ABC-type proline glycine betaine transport system permease component
EKD16_RS08905	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EKD16_RS08910	COG0583	DNA-binding transcription factor activity
EKD16_RS08920	COG1609	Transcriptional regulator
EKD16_RS08955	COG4638	Rieske (2fe-2S)
EKD16_RS08960	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
EKD16_RS08975	COG0028	Belongs to the TPP enzyme family
EKD16_RS08980	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EKD16_RS09025	COG1012	belongs to the aldehyde dehydrogenase family
EKD16_RS09045	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EKD16_RS09060	COG2815	serine threonine protein kinase
EKD16_RS09060	COG0515	serine threonine protein kinase
EKD16_RS09145	COG1879	ABC-type sugar transport system periplasmic component
EKD16_RS09150	COG1129	ABC transporter
EKD16_RS09155	COG1172	Belongs to the binding-protein-dependent transport system permease family
EKD16_RS09160	COG1063	alcohol dehydrogenase
EKD16_RS09180	COG4948	Mandelate Racemase Muconate Lactonizing
EKD16_RS09220	COG2018	Roadblock/LC7 domain
EKD16_RS09255	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EKD16_RS09260	COG0596	Alpha beta hydrolase
EKD16_RS09260	COG0508	dehydrogenase complex catalyzes the overall conversion of
EKD16_RS09265	COG1960	acyl-CoA dehydrogenase activity
EKD16_RS09275	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EKD16_RS09285	COG1252	NADH dehydrogenase
EKD16_RS09290	COG2608	mercury ion transmembrane transporter activity
EKD16_RS09295	COG1937	Protein conserved in bacteria
EKD16_RS09370	COG2226	methyltransferase
EKD16_RS09375	COG0686	Belongs to the AlaDH PNT family
EKD16_RS09385	COG3336	cytochrome c oxidase
EKD16_RS09405	COG0656	L-ascorbic acid biosynthetic process
EKD16_RS09410	COG0419	ATPase involved in DNA repair
EKD16_RS09415	COG0420	3'-5' exonuclease activity
EKD16_RS09435	COG0601	transmembrane transport
EKD16_RS09440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EKD16_RS09450	COG4608	Belongs to the ABC transporter superfamily
EKD16_RS09455	COG2124	cytochrome p450
EKD16_RS09475	COG2362	D-Aminopeptidase
EKD16_RS09480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EKD16_RS09490	COG1619	proteins homologs of microcin C7 resistance protein MccF
EKD16_RS09505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EKD16_RS09510	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EKD16_RS09515	COG2197	response regulator
EKD16_RS09520	COG0174	glutamine synthetase
EKD16_RS09525	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EKD16_RS09525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EKD16_RS09550	COG2076	Multidrug Resistance protein
EKD16_RS09555	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EKD16_RS09580	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EKD16_RS09585	COG0321	lipoyl(octanoyl) transferase activity
EKD16_RS09590	COG1090	epimerase
EKD16_RS09595	COG0508	dehydrogenase complex catalyzes the overall conversion of
EKD16_RS09600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EKD16_RS09605	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EKD16_RS09610	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EKD16_RS09630	COG0667	Aldo Keto reductase
EKD16_RS09650	COG0501	Belongs to the peptidase M48B family
EKD16_RS09665	COG1929	Belongs to the glycerate kinase type-1 family
EKD16_RS09675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EKD16_RS09685	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EKD16_RS09695	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EKD16_RS09700	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EKD16_RS09710	COG1376	ErfK ybiS ycfS ynhG family protein
EKD16_RS09715	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EKD16_RS09720	COG0723	plastoquinol--plastocyanin reductase activity
EKD16_RS09730	COG1845	cytochrome c oxidase, subunit III
EKD16_RS09740	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EKD16_RS09780	COG0791	NLP P60 protein
EKD16_RS09795	COG0438	transferase activity, transferring glycosyl groups
EKD16_RS09800	COG1022	Amp-dependent synthetase and ligase
EKD16_RS09810	COG1940	carbohydrate kinase activity
EKD16_RS09850	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EKD16_RS09855	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EKD16_RS09860	COG0301	tRNA thio-modification
EKD16_RS09870	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EKD16_RS09875	COG2197	response regulator
EKD16_RS09880	COG2815	serine threonine protein kinase
EKD16_RS09880	COG0515	serine threonine protein kinase
EKD16_RS09885	COG2022	thiamine diphosphate biosynthetic process
EKD16_RS09905	COG0352	thiamine-phosphate diphosphorylase activity
EKD16_RS09915	COG0702	epimerase
EKD16_RS09925	COG0142	geranyltranstransferase activity
EKD16_RS09945	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EKD16_RS09950	COG0540	Belongs to the ATCase OTCase family
EKD16_RS09955	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EKD16_RS09960	COG0505	Belongs to the CarA family
EKD16_RS09965	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EKD16_RS09970	COG0543	2 iron, 2 sulfur cluster binding
EKD16_RS09975	COG0167	dihydroorotate dehydrogenase activity
EKD16_RS09980	COG0284	orotidine-5'-phosphate decarboxylase activity
EKD16_RS09990	COG0194	GDP metabolic process
EKD16_RS09995	COG1758	RNA polymerase activity
EKD16_RS10005	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EKD16_RS10020	COG1960	acyl-CoA dehydrogenase activity
EKD16_RS10070	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EKD16_RS10080	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EKD16_RS10085	COG0671	phosphoesterase, PA-phosphatase related
EKD16_RS10095	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EKD16_RS10095	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EKD16_RS10100	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EKD16_RS10110	COG0542	response to heat
EKD16_RS10120	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
EKD16_RS10130	COG2017	converts alpha-aldose to the beta-anomer
EKD16_RS10160	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EKD16_RS10165	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EKD16_RS10170	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EKD16_RS10175	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EKD16_RS10180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EKD16_RS10185	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EKD16_RS10190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EKD16_RS10200	COG1305	Transglutaminase-like
EKD16_RS10210	COG0714	Associated with various cellular activities
EKD16_RS10215	COG2001	Belongs to the MraZ family
EKD16_RS10220	COG0275	rRNA processing
EKD16_RS10230	COG0768	penicillin binding
EKD16_RS10235	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EKD16_RS10245	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EKD16_RS10250	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EKD16_RS10260	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EKD16_RS10265	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EKD16_RS10270	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EKD16_RS10275	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EKD16_RS10280	COG1496	oxidoreductase activity
EKD16_RS10290	COG1799	cell septum assembly
EKD16_RS10300	COG3599	regulation of cell shape
EKD16_RS10310	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EKD16_RS10320	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EKD16_RS10350	COG2207	Transcriptional regulator
EKD16_RS10355	COG2153	protein acetylation
EKD16_RS10400	COG2318	DinB family
EKD16_RS10415	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EKD16_RS10425	COG1528	Iron-storage protein
EKD16_RS10430	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EKD16_RS10435	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EKD16_RS10440	COG0131	Imidazoleglycerol-phosphate dehydratase
EKD16_RS10445	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EKD16_RS10450	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EKD16_RS10455	COG0107	imidazoleglycerol-phosphate synthase activity
EKD16_RS10465	COG1132	(ABC) transporter
EKD16_RS10470	COG1132	(ABC) transporter
EKD16_RS10480	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EKD16_RS10505	COG0134	indole-3-glycerol-phosphate synthase activity
EKD16_RS10510	COG0133	tryptophan synthase activity
EKD16_RS10515	COG0159	tryptophan synthase activity
EKD16_RS10530	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EKD16_RS10550	COG0069	glutamate synthase activity
EKD16_RS10550	COG0067	glutamate synthase
EKD16_RS10550	COG0070	glutamate synthase
EKD16_RS10560	COG2353	YceI-like domain
EKD16_RS10565	COG1131	(ABC) transporter
EKD16_RS10585	COG0693	protein deglycase activity
EKD16_RS10655	COG2050	protein possibly involved in aromatic compounds catabolism
EKD16_RS10670	COG0539	negative regulation of cytoplasmic translation
EKD16_RS10680	COG0237	dephospho-CoA kinase activity
EKD16_RS10695	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EKD16_RS10700	COG0124	histidyl-tRNA synthetase
EKD16_RS10715	COG2226	methyltransferase
EKD16_RS10760	COG0556	nucleotide-excision repair
EKD16_RS10780	COG1131	(ABC) transporter
EKD16_RS10785	COG4585	Histidine kinase
EKD16_RS10790	COG2197	response regulator
EKD16_RS10795	COG0504	CTP synthase activity
EKD16_RS10820	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EKD16_RS10825	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EKD16_RS10845	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EKD16_RS10850	COG1160	GTP binding
EKD16_RS10900	COG1597	lipid kinase activity
EKD16_RS10920	COG1175	transmembrane transport
EKD16_RS10925	COG0395	ABC-type sugar transport system, permease component
EKD16_RS10930	COG1414	Transcriptional regulator
EKD16_RS10975	COG3903	Transcriptional regulator
EKD16_RS10975	COG3629	intracellular signal transduction
EKD16_RS10980	COG1501	Belongs to the glycosyl hydrolase 31 family
EKD16_RS10985	COG0395	ABC-type sugar transport system, permease component
EKD16_RS10990	COG1175	transmembrane transport
EKD16_RS11000	COG1609	Transcriptional regulator
EKD16_RS11010	COG0574	Belongs to the PEP-utilizing enzyme family
EKD16_RS11010	COG3848	Pyruvate phosphate dikinase
EKD16_RS11055	COG0698	ribose 5-phosphate isomerase
EKD16_RS11060	COG2376	Dihydroxyacetone kinase
EKD16_RS11065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EKD16_RS11075	COG2814	Major facilitator Superfamily
EKD16_RS11100	COG2015	COG2015, Alkyl sulfatase and related hydrolases
EKD16_RS11110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EKD16_RS11115	COG2124	cytochrome p450
EKD16_RS11160	COG0656	L-ascorbic acid biosynthetic process
EKD16_RS11180	COG1595	DNA-templated transcription, initiation
EKD16_RS11190	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EKD16_RS11200	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EKD16_RS11205	COG1285	pathogenesis
EKD16_RS11210	COG3387	PFAM Glycoside hydrolase 15-related
EKD16_RS11215	COG2364	Membrane
EKD16_RS11220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EKD16_RS11230	COG2267	carboxylic ester hydrolase activity
EKD16_RS11235	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EKD16_RS11245	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EKD16_RS11260	COG3360	Dodecin
EKD16_RS11285	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EKD16_RS11290	COG1316	TRANSCRIPTIONal
EKD16_RS11300	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EKD16_RS11305	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EKD16_RS11310	COG3540	Alkaline phosphatase
EKD16_RS11335	COG2186	Transcriptional regulator
EKD16_RS11340	COG2807	transmembrane transport
EKD16_RS11365	COG1960	acyl-CoA dehydrogenase activity
EKD16_RS11375	COG1309	transcriptional regulator
EKD16_RS11395	COG1609	Transcriptional regulator
EKD16_RS11430	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
EKD16_RS11450	COG1966	Carbon starvation protein
EKD16_RS11460	COG0003	Pfam Anion-transporting ATPase
EKD16_RS11470	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EKD16_RS11475	COG1716	ATPase activity
EKD16_RS11490	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
EKD16_RS11500	COG0277	FAD linked oxidase domain protein
EKD16_RS11510	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EKD16_RS11510	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EKD16_RS11530	COG1515	deoxyribonuclease V activity
EKD16_RS11540	COG2197	response regulator
EKD16_RS11545	COG4585	Histidine kinase
EKD16_RS11555	COG1994	Peptidase M50
EKD16_RS11555	COG0517	IMP dehydrogenase activity
EKD16_RS11590	COG1222	aaa ATPase
EKD16_RS11595	COG4122	O-methyltransferase activity
EKD16_RS11605	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
EKD16_RS11610	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
EKD16_RS11615	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
EKD16_RS11635	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EKD16_RS11655	COG0438	transferase activity, transferring glycosyl groups
EKD16_RS11660	COG1960	acyl-CoA dehydrogenase activity
EKD16_RS11670	COG1653	transport
EKD16_RS11675	COG1175	transmembrane transport
EKD16_RS11680	COG0395	ABC-type sugar transport system, permease component
EKD16_RS11685	COG3842	ATPase activity
EKD16_RS11690	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EKD16_RS11710	COG2124	cytochrome p450
EKD16_RS11740	COG0673	inositol 2-dehydrogenase activity
EKD16_RS11810	COG0028	Belongs to the TPP enzyme family
EKD16_RS11830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EKD16_RS11835	COG1181	Belongs to the D-alanine--D-alanine ligase family
EKD16_RS11860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EKD16_RS11875	COG0045	succinate-CoA ligase (ADP-forming) activity
EKD16_RS11885	COG1012	belongs to the aldehyde dehydrogenase family
EKD16_RS11895	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EKD16_RS11905	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EKD16_RS11915	COG3383	formate dehydrogenase (NAD+) activity
EKD16_RS11920	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EKD16_RS11925	COG1802	Transcriptional regulator
EKD16_RS11975	COG1846	Transcriptional regulator
EKD16_RS11980	COG1764	response to oxidative stress
EKD16_RS11995	COG1253	flavin adenine dinucleotide binding
EKD16_RS12000	COG1253	flavin adenine dinucleotide binding
EKD16_RS12005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EKD16_RS12035	COG0494	nUDIX hydrolase
EKD16_RS12040	COG1011	Hydrolase
EKD16_RS12045	COG2304	oxidoreductase activity
EKD16_RS12055	COG0714	Associated with various cellular activities
EKD16_RS12065	COG2154	pterin-4-alpha-carbinolamine dehydratase
EKD16_RS12070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EKD16_RS12095	COG4106	trans-aconitate 2-methyltransferase activity
EKD16_RS12120	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EKD16_RS12130	COG0477	Major facilitator Superfamily
EKD16_RS12140	COG0512	Glutamine amidotransferase of anthranilate synthase
EKD16_RS12140	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EKD16_RS12150	COG0800	Aldolase
EKD16_RS12155	COG0837	glucose binding
EKD16_RS12165	COG1846	Transcriptional regulator
EKD16_RS12165	COG1940	carbohydrate kinase activity
EKD16_RS12170	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EKD16_RS12175	COG0587	DNA-directed DNA polymerase activity
EKD16_RS12185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EKD16_RS12215	COG1121	(ABC) transporter
EKD16_RS12220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EKD16_RS12230	COG0243	molybdopterin cofactor binding
EKD16_RS12235	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EKD16_RS12240	COG2080	2 iron, 2 sulfur cluster binding
EKD16_RS12245	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
EKD16_RS12250	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EKD16_RS12255	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EKD16_RS12255	COG2146	nitrite reductase [NAD(P)H] activity
EKD16_RS12280	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EKD16_RS12330	COG1113	amino acid transport
EKD16_RS12335	COG3540	Alkaline phosphatase
EKD16_RS12340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EKD16_RS12365	COG0640	Transcriptional regulator
EKD16_RS12380	COG0028	Belongs to the TPP enzyme family
EKD16_RS12415	COG1234	tRNA 3'-trailer cleavage
EKD16_RS12420	COG1301	dicarboxylic acid transport
EKD16_RS12455	COG4106	trans-aconitate 2-methyltransferase activity
EKD16_RS12490	COG0596	Alpha beta hydrolase
EKD16_RS12510	COG0439	Biotin carboxylase
EKD16_RS12530	COG2318	DinB family
EKD16_RS12555	COG2264	protein methyltransferase activity
EKD16_RS12560	COG1252	NADH dehydrogenase
EKD16_RS12565	COG1846	Transcriptional regulator
EKD16_RS12585	COG0492	ferredoxin-NADP+ reductase activity
EKD16_RS12590	COG2226	methyltransferase
EKD16_RS12600	COG0655	NAD(P)H dehydrogenase (quinone) activity
EKD16_RS12615	COG0210	DNA helicase
EKD16_RS12620	COG1205	dead DEAH box helicase
EKD16_RS12620	COG1111	helicase
EKD16_RS12625	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EKD16_RS12630	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EKD16_RS12690	COG1401	restriction endodeoxyribonuclease activity
EKD16_RS12700	COG0210	DNA helicase
EKD16_RS12715	COG4977	sequence-specific DNA binding
EKD16_RS12725	COG1216	Glycosyl transferase, family 2
EKD16_RS12725	COG1442	glycosyl transferase family 8
EKD16_RS12730	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EKD16_RS12790	COG1028	Short-chain dehydrogenase reductase Sdr
EKD16_RS12800	COG2814	Major facilitator Superfamily
EKD16_RS12810	COG0242	peptide deformylase activity
EKD16_RS12830	COG2197	response regulator
EKD16_RS12835	COG1022	Amp-dependent synthetase and ligase
EKD16_RS12840	COG2814	Major facilitator Superfamily
EKD16_RS12870	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EKD16_RS12890	COG1278	Cold shock
EKD16_RS12905	COG0247	lactate metabolic process
EKD16_RS12905	COG0277	FAD linked oxidase domain protein
EKD16_RS12920	COG1999	signal sequence binding
EKD16_RS12930	COG2837	iron assimilation
EKD16_RS12940	COG1028	Short-chain dehydrogenase reductase Sdr
EKD16_RS12965	COG4145	pantothenate transmembrane transporter activity
EKD16_RS12980	COG2910	NAD(P)H-binding
EKD16_RS12995	COG2040	homocysteine
EKD16_RS13000	COG3665	Urea carboxylase-associated protein
EKD16_RS13030	COG0730	response to heat
EKD16_RS13035	COG2390	Transcriptional regulator
EKD16_RS13040	COG1063	alcohol dehydrogenase
EKD16_RS13055	COG0395	ABC-type sugar transport system, permease component
EKD16_RS13060	COG0673	inositol 2-dehydrogenase activity
EKD16_RS13065	COG0583	DNA-binding transcription factor activity
EKD16_RS13070	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EKD16_RS13075	COG0318	PFAM AMP-dependent synthetase and ligase
EKD16_RS13075	COG0204	Acyl-transferase
EKD16_RS13090	COG0006	proline dipeptidase activity
EKD16_RS13105	COG0596	Alpha beta hydrolase
EKD16_RS13125	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EKD16_RS13130	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EKD16_RS13135	COG4608	Belongs to the ABC transporter superfamily
EKD16_RS13140	COG0444	Belongs to the ABC transporter superfamily
EKD16_RS13150	COG0601	transmembrane transport
EKD16_RS13165	COG0395	ABC-type sugar transport system, permease component
EKD16_RS13170	COG1175	transmembrane transport
EKD16_RS13180	COG1609	Transcriptional regulator
EKD16_RS13190	COG3693	PFAM glycoside hydrolase, family 10
EKD16_RS13190	COG3507	Belongs to the glycosyl hydrolase 43 family
EKD16_RS13190	COG2382	esterase
EKD16_RS13235	COG4566	intracellular signal transduction
EKD16_RS13250	COG4211	Belongs to the binding-protein-dependent transport system permease family
EKD16_RS13290	COG1028	Short-chain dehydrogenase reductase Sdr
EKD16_RS13295	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EKD16_RS13295	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EKD16_RS13300	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EKD16_RS13305	COG0438	transferase activity, transferring glycosyl groups
EKD16_RS13320	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EKD16_RS13325	COG2192	nodulation
EKD16_RS13330	COG0542	response to heat
EKD16_RS13345	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EKD16_RS13355	COG0517	IMP dehydrogenase activity
EKD16_RS13390	COG2814	Major facilitator Superfamily
EKD16_RS13405	COG3835	regulator
EKD16_RS13430	COG4221	oxidoreductase activity
EKD16_RS13460	COG2186	Transcriptional regulator
EKD16_RS13465	COG0247	lactate metabolic process
EKD16_RS13470	COG1139	Iron-sulfur cluster binding protein
EKD16_RS13475	COG1556	Lactate utilization protein
EKD16_RS13505	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EKD16_RS13535	COG0598	Magnesium transport protein CorA
EKD16_RS13605	COG1289	transmembrane transporter activity
EKD16_RS13615	COG4948	Mandelate Racemase Muconate Lactonizing
EKD16_RS13620	COG1063	alcohol dehydrogenase
EKD16_RS13635	COG0204	Acyl-transferase
EKD16_RS13660	COG1649	PFAM Uncharacterised BCR, COG1649
EKD16_RS13675	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EKD16_RS13680	COG4948	Mandelate Racemase Muconate Lactonizing
EKD16_RS13685	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EKD16_RS13725	COG4585	Histidine kinase
EKD16_RS13735	COG4172	Belongs to the ABC transporter superfamily
EKD16_RS13740	COG0601	transmembrane transport
EKD16_RS13745	COG0747	negative chemotaxis
EKD16_RS13750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EKD16_RS13765	COG1410	methionine synthase
EKD16_RS13765	COG0646	methionine synthase
EKD16_RS13780	COG0215	cysteine-tRNA ligase activity
EKD16_RS13810	COG0406	alpha-ribazole phosphatase activity
EKD16_RS13815	COG1968	undecaprenyl-diphosphatase activity
EKD16_RS13820	COG0667	Aldo Keto reductase
EKD16_RS13845	COG1028	Short-chain dehydrogenase reductase Sdr
EKD16_RS13850	COG0435	Glutathione S-transferase
EKD16_RS13860	COG0587	DNA-directed DNA polymerase activity
EKD16_RS13865	COG2323	membrane
EKD16_RS13875	COG2197	response regulator
EKD16_RS13885	COG1136	(ABC) transporter
EKD16_RS13885	COG0577	efflux transmembrane transporter activity
EKD16_RS13895	COG0477	Major facilitator Superfamily
EKD16_RS13905	COG0463	Glycosyl transferase, family 2
EKD16_RS13915	COG2091	lysine biosynthetic process via aminoadipic acid
EKD16_RS13940	COG0477	Major facilitator Superfamily
EKD16_RS13950	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EKD16_RS13980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EKD16_RS13985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EKD16_RS13995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EKD16_RS14005	COG3433	isochorismatase activity
EKD16_RS14005	COG1535	isochorismatase
EKD16_RS14010	COG3486	L-lysine 6-monooxygenase (NADPH) activity
EKD16_RS14020	COG1021	2,3-dihydroxybenzoate-AMP ligase
EKD16_RS14025	COG1169	isochorismate synthase
EKD16_RS14030	COG1028	Short-chain dehydrogenase reductase Sdr
EKD16_RS14040	COG0628	permease
EKD16_RS14050	COG2205	protein histidine kinase activity
EKD16_RS14065	COG0701	Predicted permease
EKD16_RS14075	COG1024	Enoyl-CoA hydratase
EKD16_RS14085	COG0488	(ABC) transporter
EKD16_RS14090	COG0628	permease
EKD16_RS14115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EKD16_RS14145	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EKD16_RS14155	COG0175	sulfate reduction
EKD16_RS14175	COG1960	acyl-CoA dehydrogenase activity
EKD16_RS14190	COG2188	Transcriptional regulator
EKD16_RS14200	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EKD16_RS14205	COG0688	phosphatidylethanolamine metabolic process
EKD16_RS14215	COG3253	May function as heme-dependent peroxidase
EKD16_RS14220	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EKD16_RS14230	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EKD16_RS14250	COG0183	Belongs to the thiolase family
EKD16_RS14255	COG1024	Enoyl-CoA hydratase
EKD16_RS14255	COG1250	3-hydroxyacyl-CoA dehydrogenase
EKD16_RS14265	COG2409	Drug exporters of the RND superfamily
EKD16_RS14285	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EKD16_RS14300	COG4214	carbohydrate transport
EKD16_RS14305	COG1129	ABC transporter
EKD16_RS14310	COG4213	ABC transporter substrate-binding protein
EKD16_RS14315	COG1940	carbohydrate kinase activity
EKD16_RS14340	COG1595	DNA-templated transcription, initiation
EKD16_RS14360	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EKD16_RS14375	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EKD16_RS14380	COG0569	domain protein
EKD16_RS14405	COG0756	dUTP diphosphatase activity
EKD16_RS14410	COG0525	valine-tRNA ligase activity
EKD16_RS14430	COG2205	protein histidine kinase activity
EKD16_RS14435	COG0745	RESPONSE REGULATOR receiver
EKD16_RS14445	COG0823	Involved in the tonB-independent uptake of proteins
EKD16_RS14445	COG1506	peptidase
EKD16_RS14450	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EKD16_RS14490	COG4326	sporulation control protein
EKD16_RS14510	COG0288	reversible hydration of carbon dioxide
EKD16_RS14540	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EKD16_RS14550	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EKD16_RS14580	COG2183	response to ionizing radiation
EKD16_RS14600	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EKD16_RS14605	COG3395	kinase activity
EKD16_RS14610	COG2610	gluconate transmembrane transporter activity
EKD16_RS14615	COG1349	DNA-binding transcription factor activity
EKD16_RS14620	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EKD16_RS14635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EKD16_RS14640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EKD16_RS14645	COG3959	Transketolase, thiamine diphosphate binding domain
EKD16_RS14665	COG3401	FG-GAP repeat protein
EKD16_RS14685	COG0432	Pfam Uncharacterised protein family UPF0047
EKD16_RS14700	COG4336	lyase activity
EKD16_RS14705	COG1984	allophanate hydrolase subunit 2
EKD16_RS14740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EKD16_RS14745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EKD16_RS14780	COG2151	metal-sulfur cluster biosynthetic enzyme
EKD16_RS14785	COG0822	iron-sulfur transferase activity
EKD16_RS14795	COG0396	ATPase activity
EKD16_RS14820	COG1131	(ABC) transporter
EKD16_RS14840	COG2235	arginine
EKD16_RS14845	COG5006	permease, DMT superfamily
EKD16_RS14850	COG0557	exoribonuclease II activity
EKD16_RS14855	COG2409	Drug exporters of the RND superfamily
EKD16_RS14890	COG2018	Roadblock/LC7 domain
EKD16_RS14895	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EKD16_RS14900	COG1609	Transcriptional regulator
EKD16_RS14905	COG1129	ABC transporter
EKD16_RS14910	COG1172	Belongs to the binding-protein-dependent transport system permease family
EKD16_RS14915	COG1172	Belongs to the binding-protein-dependent transport system permease family
EKD16_RS14925	COG3254	rhamnose metabolic process
EKD16_RS14930	COG4952	isomerase
EKD16_RS14940	COG1028	Short-chain dehydrogenase reductase Sdr
EKD16_RS14940	COG3347	Dehydrogenase
EKD16_RS14945	COG1070	Carbohydrate kinase
EKD16_RS14955	COG1960	acyl-CoA dehydrogenase activity
EKD16_RS14965	COG1482	cell wall glycoprotein biosynthetic process
EKD16_RS14975	COG2610	gluconate transmembrane transporter activity
EKD16_RS14985	COG3265	gluconokinase activity
EKD16_RS14990	COG1414	Transcriptional regulator
EKD16_RS15010	COG0303	'Molybdopterin
EKD16_RS15045	COG1120	ATPase activity
EKD16_RS15050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EKD16_RS15060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EKD16_RS15075	COG0477	Major facilitator Superfamily
EKD16_RS15125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EKD16_RS15130	COG1819	glycosyl
EKD16_RS15140	COG2197	response regulator
EKD16_RS15145	COG4585	Histidine kinase
EKD16_RS15155	COG1131	(ABC) transporter
EKD16_RS15170	COG1088	dTDP-glucose 4,6-dehydratase activity
EKD16_RS15175	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EKD16_RS15180	COG1278	Cold shock
EKD16_RS15230	COG2814	Major facilitator Superfamily
EKD16_RS15235	COG0640	Transcriptional regulator
EKD16_RS15250	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EKD16_RS15285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EKD16_RS15295	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EKD16_RS15300	COG2072	flavoprotein involved in K transport
EKD16_RS15315	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EKD16_RS15335	COG0702	epimerase
EKD16_RS15350	COG0156	8-amino-7-oxononanoate synthase activity
EKD16_RS15355	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EKD16_RS15375	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EKD16_RS15385	COG0662	Cupin 2, conserved barrel domain protein
EKD16_RS15390	COG1960	acyl-CoA dehydrogenase activity
EKD16_RS15395	COG0135	phosphoribosylanthranilate isomerase activity
EKD16_RS15400	COG0134	indole-3-glycerol-phosphate synthase activity
EKD16_RS15410	COG3279	Response regulator of the LytR AlgR family
EKD16_RS15415	COG3275	phosphorelay sensor kinase activity
EKD16_RS15440	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EKD16_RS15465	COG2188	Transcriptional regulator
EKD16_RS15480	COG3507	Belongs to the glycosyl hydrolase 43 family
EKD16_RS15485	COG0402	S-adenosylhomocysteine deaminase activity
EKD16_RS15490	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EKD16_RS15500	COG3485	protocatechuate 3,4-dioxygenase
EKD16_RS15510	COG1414	Transcriptional regulator
EKD16_RS15520	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EKD16_RS15525	COG0477	Major facilitator Superfamily
EKD16_RS15530	COG1846	Transcriptional regulator
EKD16_RS15550	COG1609	Transcriptional regulator
EKD16_RS15570	COG4941	Belongs to the sigma-70 factor family
EKD16_RS15590	COG1733	regulation of RNA biosynthetic process
EKD16_RS15595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EKD16_RS15600	COG0129	dihydroxy-acid dehydratase activity
EKD16_RS15605	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
EKD16_RS15610	COG1691	(AIR) carboxylase
EKD16_RS15615	COG1606	tRNA processing
EKD16_RS15620	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
EKD16_RS15650	COG4948	Mandelate Racemase Muconate Lactonizing
EKD16_RS15685	COG2197	response regulator
EKD16_RS15705	COG2124	cytochrome p450
EKD16_RS15720	COG1132	(ABC) transporter
EKD16_RS15745	COG0109	protoheme IX farnesyltransferase activity
EKD16_RS15755	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EKD16_RS15770	COG0363	glucosamine-6-phosphate deaminase activity
EKD16_RS15780	COG0395	ABC-type sugar transport system, permease component
EKD16_RS15785	COG1175	transmembrane transport
EKD16_RS15790	COG0673	inositol 2-dehydrogenase activity
EKD16_RS15865	COG2814	Major facilitator Superfamily
EKD16_RS15870	COG1959	2 iron, 2 sulfur cluster binding
EKD16_RS15890	COG1228	amidohydrolase
EKD16_RS15895	COG0402	S-adenosylhomocysteine deaminase activity
EKD16_RS15905	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EKD16_RS15910	COG2986	histidine ammonia-lyase
EKD16_RS15915	COG0583	DNA-binding transcription factor activity
EKD16_RS15935	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EKD16_RS15940	COG0149	triose-phosphate isomerase activity
EKD16_RS15945	COG0126	phosphoglycerate kinase activity
EKD16_RS15950	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EKD16_RS15955	COG1481	regulation of sporulation
EKD16_RS15960	COG3189	MarR family transcriptional regulator
EKD16_RS15970	COG1660	Displays ATPase and GTPase activities
EKD16_RS15975	COG0322	excinuclease ABC activity
EKD16_RS15995	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EKD16_RS16005	COG0497	DNA recombination
EKD16_RS16010	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EKD16_RS16040	COG0647	UMP catabolic process
EKD16_RS16060	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EKD16_RS16090	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EKD16_RS16100	COG1309	transcriptional regulator
EKD16_RS16115	COG0579	oxidoreductase
EKD16_RS16155	COG0165	Argininosuccinate lyase
EKD16_RS16160	COG0137	argininosuccinate synthase activity
EKD16_RS16165	COG1438	arginine binding
EKD16_RS16170	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EKD16_RS16175	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EKD16_RS16180	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EKD16_RS16185	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EKD16_RS16190	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EKD16_RS16200	COG1846	Transcriptional regulator
EKD16_RS16210	COG0072	phenylalanine-tRNA ligase activity
EKD16_RS16210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EKD16_RS16215	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EKD16_RS16220	COG5002	protein histidine kinase activity
EKD16_RS16225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EKD16_RS16230	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EKD16_RS16235	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EKD16_RS16240	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EKD16_RS16245	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EKD16_RS16250	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EKD16_RS16255	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EKD16_RS16260	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EKD16_RS16300	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EKD16_RS16310	COG1196	nuclear chromosome segregation
EKD16_RS16320	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EKD16_RS16325	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EKD16_RS16330	COG1862	Preprotein translocase
EKD16_RS16335	COG2255	four-way junction helicase activity
EKD16_RS16340	COG0632	four-way junction helicase activity
EKD16_RS16345	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EKD16_RS16355	COG0217	transcriptional regulatory protein
EKD16_RS16360	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
EKD16_RS16365	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
EKD16_RS16375	COG0438	transferase activity, transferring glycosyl groups
EKD16_RS16380	COG1560	Kdo2-lipid A biosynthetic process
EKD16_RS16385	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EKD16_RS16400	COG1253	flavin adenine dinucleotide binding
EKD16_RS16410	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EKD16_RS16430	COG2018	Roadblock/LC7 domain
EKD16_RS16450	COG2723	6-phospho-beta-galactosidase activity
EKD16_RS16455	COG0395	ABC-type sugar transport system, permease component
EKD16_RS16485	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EKD16_RS16490	COG0726	polysaccharide deacetylase
EKD16_RS16505	COG0167	dihydroorotate dehydrogenase activity
EKD16_RS16540	COG1522	sequence-specific DNA binding
EKD16_RS16555	COG0508	dehydrogenase complex catalyzes the overall conversion of
EKD16_RS16575	COG1522	sequence-specific DNA binding
EKD16_RS16620	COG0346	lactoylglutathione lyase activity
EKD16_RS16625	COG1349	DNA-binding transcription factor activity
EKD16_RS16660	COG1070	Carbohydrate kinase
EKD16_RS16670	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EKD16_RS16675	COG2146	nitrite reductase [NAD(P)H] activity
EKD16_RS16685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EKD16_RS16690	COG4638	Rieske (2fe-2S)
EKD16_RS16705	COG0129	dihydroxy-acid dehydratase activity
EKD16_RS16710	COG1414	Transcriptional regulator
EKD16_RS16730	COG1414	Transcriptional regulator
EKD16_RS16740	COG3964	amidohydrolase
EKD16_RS16750	COG0251	oxidation-reduction process
EKD16_RS16755	COG1349	DNA-binding transcription factor activity
EKD16_RS16775	COG4585	Histidine kinase
EKD16_RS16780	COG2197	response regulator
EKD16_RS16790	COG0437	4 iron, 4 sulfur cluster binding
EKD16_RS16800	COG1007	ATP synthesis coupled electron transport
EKD16_RS16805	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EKD16_RS16810	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EKD16_RS16825	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EKD16_RS16835	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EKD16_RS16850	COG1028	Short-chain dehydrogenase reductase Sdr
EKD16_RS16855	COG3387	PFAM Glycoside hydrolase 15-related
EKD16_RS16875	COG2197	response regulator
EKD16_RS16880	COG0640	Transcriptional regulator
EKD16_RS16885	COG0346	lactoylglutathione lyase activity
EKD16_RS16910	COG2197	response regulator
EKD16_RS16915	COG4585	Histidine kinase
EKD16_RS16920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EKD16_RS16925	COG1063	alcohol dehydrogenase
EKD16_RS16935	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EKD16_RS17000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EKD16_RS17050	COG1320	monovalent cation:proton antiporter activity
EKD16_RS17055	COG2212	antiporter activity
EKD16_RS17065	COG0651	ATP synthesis coupled electron transport
EKD16_RS17070	COG1006	Multisubunit Na H antiporter MnhC subunit
EKD16_RS17075	COG2111	Na H antiporter
EKD16_RS17080	COG2111	Na H antiporter
EKD16_RS17080	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EKD16_RS17085	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EKD16_RS17105	COG0187	DNA topoisomerase II activity
EKD16_RS17115	COG0456	acetyltransferase
EKD16_RS17120	COG3022	response to hydroperoxide
EKD16_RS17125	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EKD16_RS17125	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EKD16_RS17150	COG2365	Tyrosine phosphatase family
EKD16_RS17155	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EKD16_RS17165	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EKD16_RS17220	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EKD16_RS17225	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EKD16_RS17235	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EKD16_RS17255	COG0495	leucyl-tRNA aminoacylation
EKD16_RS17270	COG0318	PFAM AMP-dependent synthetase and ligase
EKD16_RS17280	COG1472	Belongs to the glycosyl hydrolase 3 family
EKD16_RS17285	COG0395	ABC-type sugar transport system, permease component
EKD16_RS17290	COG1175	transmembrane transport
EKD16_RS17310	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EKD16_RS17320	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EKD16_RS17390	COG0477	Major facilitator Superfamily
EKD16_RS17400	COG0406	alpha-ribazole phosphatase activity
EKD16_RS17410	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EKD16_RS17415	COG0501	Belongs to the peptidase M48B family
EKD16_RS17420	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EKD16_RS17430	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EKD16_RS17435	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EKD16_RS17440	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EKD16_RS17445	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EKD16_RS17450	COG1530	ribonuclease E activity
EKD16_RS17465	COG0772	Belongs to the SEDS family
EKD16_RS17490	COG0105	UTP biosynthetic process
EKD16_RS17500	COG0285	dihydrofolate synthase activity
EKD16_RS17515	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EKD16_RS17520	COG0740	serine-type endopeptidase activity
EKD16_RS17525	COG0740	serine-type endopeptidase activity
EKD16_RS17530	COG0544	peptidyl-prolyl cis-trans isomerase activity
EKD16_RS17565	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EKD16_RS17565	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EKD16_RS17570	COG1132	(ABC) transporter
EKD16_RS17590	COG2239	Acts as a magnesium transporter
EKD16_RS17600	COG4552	Acetyltransferase involved in intracellular survival and related
EKD16_RS17605	COG0698	ribose 5-phosphate isomerase
EKD16_RS17615	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EKD16_RS17645	COG0129	dihydroxy-acid dehydratase activity
EKD16_RS17660	COG1505	serine-type exopeptidase activity
EKD16_RS17685	COG2271	Major facilitator Superfamily
EKD16_RS17720	COG1160	GTP binding
EKD16_RS17725	COG1648	precorrin-2 dehydrogenase activity
EKD16_RS17725	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EKD16_RS17730	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EKD16_RS17755	COG0310	cobalt ion transport
EKD16_RS17760	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
EKD16_RS17770	COG1122	ATPase activity
EKD16_RS17790	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
EKD16_RS17805	COG1797	cobyrinic acid a,c-diamide synthase activity
EKD16_RS17880	COG3850	Histidine kinase
EKD16_RS17880	COG5002	protein histidine kinase activity
EKD16_RS17885	COG0745	RESPONSE REGULATOR receiver
EKD16_RS17895	COG1132	(ABC) transporter
EKD16_RS17915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EKD16_RS17920	COG0085	RNA polymerase activity
EKD16_RS17945	COG0659	secondary active sulfate transmembrane transporter activity
EKD16_RS17950	COG0789	Transcriptional regulator
EKD16_RS17955	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EKD16_RS17965	COG1132	(ABC) transporter
EKD16_RS17970	COG1132	(ABC) transporter
EKD16_RS17980	COG0515	serine threonine protein kinase
EKD16_RS18005	COG2197	response regulator
EKD16_RS18015	COG0477	Major facilitator Superfamily
EKD16_RS18060	COG4585	Histidine kinase
EKD16_RS18075	COG2271	Major facilitator Superfamily
EKD16_RS18110	COG0439	Biotin carboxylase
EKD16_RS18210	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
EKD16_RS18215	COG1492	cobalamin metabolic process
EKD16_RS18225	COG3467	pyridoxamine 5'-phosphate
EKD16_RS18245	COG3866	Pectate lyase
EKD16_RS18255	COG1028	Short-chain dehydrogenase reductase Sdr
EKD16_RS18265	COG1914	H( )-stimulated, divalent metal cation uptake system
EKD16_RS18355	COG2409	Drug exporters of the RND superfamily
EKD16_RS18360	COG0745	RESPONSE REGULATOR receiver
EKD16_RS18380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EKD16_RS18385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EKD16_RS18430	COG0673	inositol 2-dehydrogenase activity
EKD16_RS18465	COG3550	peptidyl-serine autophosphorylation
EKD16_RS18470	COG0667	Aldo Keto reductase
EKD16_RS18505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EKD16_RS18555	COG0640	Transcriptional regulator
EKD16_RS18570	COG0477	Major facilitator Superfamily
EKD16_RS18605	COG0612	Peptidase, M16
EKD16_RS18610	COG1185	polyribonucleotide nucleotidyltransferase activity
EKD16_RS18615	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EKD16_RS18625	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EKD16_RS18630	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EKD16_RS18640	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EKD16_RS18655	COG0779	Required for maturation of 30S ribosomal subunits
EKD16_RS18670	COG0442	prolyl-tRNA aminoacylation
EKD16_RS18690	COG4585	Histidine kinase
EKD16_RS18695	COG2197	response regulator
EKD16_RS18700	COG1271	oxidase subunit
EKD16_RS18705	COG1294	oxidase, subunit
EKD16_RS18735	COG0549	Belongs to the carbamate kinase family
EKD16_RS18740	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
EKD16_RS18755	COG0653	protein targeting
EKD16_RS18785	COG2233	PERMEase
EKD16_RS18805	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EKD16_RS18810	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EKD16_RS18815	COG0124	histidyl-tRNA synthetase
EKD16_RS18870	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EKD16_RS18880	COG0596	Alpha beta hydrolase
EKD16_RS18885	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EKD16_RS18890	COG0750	zinc metalloprotease
EKD16_RS18920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EKD16_RS18945	COG1609	Transcriptional regulator
EKD16_RS18960	COG0395	ABC-type sugar transport system, permease component
EKD16_RS18970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EKD16_RS18980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EKD16_RS19005	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EKD16_RS19030	COG0575	Belongs to the CDS family
EKD16_RS19035	COG0233	cytoplasmic translational termination
EKD16_RS19040	COG0528	UMP kinase activity
EKD16_RS19045	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EKD16_RS19050	COG0052	Belongs to the universal ribosomal protein uS2 family
EKD16_RS19060	COG4974	Belongs to the 'phage' integrase family
EKD16_RS19080	COG0792	nuclease activity
EKD16_RS19090	COG0681	Belongs to the peptidase S26 family
EKD16_RS19095	COG0335	large ribosomal subunit rRNA binding
EKD16_RS19100	COG0336	Belongs to the RNA methyltransferase TrmD family
EKD16_RS19105	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EKD16_RS19110	COG1837	Belongs to the UPF0109 family
EKD16_RS19115	COG0228	four-way junction DNA binding
EKD16_RS19135	COG1131	(ABC) transporter
EKD16_RS19150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EKD16_RS19160	COG1196	nuclear chromosome segregation
EKD16_RS19170	COG1254	Belongs to the acylphosphatase family
EKD16_RS19175	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EKD16_RS19180	COG0571	ribonuclease III activity
EKD16_RS19185	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EKD16_RS19190	COG1399	metal-binding, possibly nucleic acid-binding protein
EKD16_RS19195	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EKD16_RS19200	COG0742	ribosomal rna small subunit methyltransferase
EKD16_RS19210	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EKD16_RS19245	COG1271	oxidase subunit
EKD16_RS19250	COG1294	oxidase, subunit
EKD16_RS19255	COG1132	(ABC) transporter
EKD16_RS19260	COG1132	(ABC) transporter
EKD16_RS19280	COG1028	Short-chain dehydrogenase reductase Sdr
EKD16_RS19285	COG0210	DNA helicase
EKD16_RS19320	COG2072	flavoprotein involved in K transport
EKD16_RS19330	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EKD16_RS19335	COG3395	kinase activity
EKD16_RS19340	COG2814	Major facilitator Superfamily
EKD16_RS19350	COG1309	transcriptional regulator
EKD16_RS19355	COG0673	inositol 2-dehydrogenase activity
EKD16_RS19365	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EKD16_RS19380	COG2197	response regulator
EKD16_RS19385	COG4585	Histidine kinase
EKD16_RS19400	COG1028	Short-chain dehydrogenase reductase Sdr
EKD16_RS19420	COG0559	Belongs to the binding-protein-dependent transport system permease family
EKD16_RS19460	COG0784	Response regulator, receiver
EKD16_RS19465	COG4251	negative regulation of phosphorylation
EKD16_RS19475	COG5398	heme oxygenase
EKD16_RS19500	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EKD16_RS19515	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EKD16_RS19520	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EKD16_RS19525	COG0509	glycine decarboxylation via glycine cleavage system
EKD16_RS19530	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EKD16_RS19535	COG1760	l-serine dehydratase
EKD16_RS19625	COG0596	Alpha beta hydrolase
EKD16_RS19640	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EKD16_RS19645	COG1028	Short-chain dehydrogenase reductase Sdr
EKD16_RS19650	COG2226	methyltransferase
EKD16_RS19655	COG0508	dehydrogenase complex catalyzes the overall conversion of
EKD16_RS19655	COG0596	Alpha beta hydrolase
EKD16_RS19670	COG0110	maltose O-acetyltransferase activity
EKD16_RS19680	COG2755	lipolytic protein G-D-S-L family
EKD16_RS19685	COG0183	Belongs to the thiolase family
EKD16_RS19700	COG0506	proline dehydrogenase activity
EKD16_RS19705	COG1012	belongs to the aldehyde dehydrogenase family
EKD16_RS19735	COG1252	NADH dehydrogenase
EKD16_RS19750	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EKD16_RS19760	COG0148	phosphopyruvate hydratase activity
EKD16_RS19765	COG0730	response to heat
EKD16_RS19770	COG0772	Belongs to the SEDS family
EKD16_RS19780	COG0529	Catalyzes the synthesis of activated sulfate
EKD16_RS19825	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
EKD16_RS19825	COG4124	Belongs to the glycosyl hydrolase 26 family
EKD16_RS19850	COG1218	3'(2'),5'-bisphosphate nucleotidase
EKD16_RS19855	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EKD16_RS19865	COG0193	aminoacyl-tRNA hydrolase activity
EKD16_RS19870	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EKD16_RS19875	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EKD16_RS19880	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EKD16_RS19900	COG1846	Transcriptional regulator
EKD16_RS19910	COG0488	(ABC) transporter
EKD16_RS19920	COG3958	Transketolase
EKD16_RS19925	COG3959	Transketolase, thiamine diphosphate binding domain
EKD16_RS19930	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EKD16_RS19940	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EKD16_RS19945	COG1388	LysM domain
EKD16_RS19950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EKD16_RS19955	COG0084	hydrolase, TatD family'
EKD16_RS19960	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EKD16_RS19970	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EKD16_RS19970	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EKD16_RS19995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EKD16_RS20020	COG0315	cyclic pyranopterin monophosphate synthase activity
EKD16_RS20020	COG0521	Mo-molybdopterin cofactor biosynthetic process
EKD16_RS20025	COG0315	cyclic pyranopterin monophosphate synthase activity
EKD16_RS20035	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EKD16_RS20040	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EKD16_RS20055	COG1876	peptidase activity
EKD16_RS20085	COG0328	RNA-DNA hybrid ribonuclease activity
EKD16_RS20090	COG3739	integral membrane protein
EKD16_RS20125	COG2084	Dehydrogenase
EKD16_RS20155	COG1175	transmembrane transport
EKD16_RS20160	COG0395	ABC-type sugar transport system, permease component
EKD16_RS20170	COG1472	Belongs to the glycosyl hydrolase 3 family
EKD16_RS20175	COG0667	Aldo Keto reductase
EKD16_RS20190	COG1476	TRANSCRIPTIONal
EKD16_RS20200	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
EKD16_RS20215	COG1028	Short-chain dehydrogenase reductase Sdr
EKD16_RS20225	COG0589	response to stress
EKD16_RS20265	COG2197	response regulator
EKD16_RS20270	COG4585	Histidine kinase
EKD16_RS20290	COG3842	ATPase activity
EKD16_RS20310	COG1051	belongs to the nudix hydrolase family
EKD16_RS20330	COG1072	(Pantothenic acid kinase))
EKD16_RS20340	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EKD16_RS20345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EKD16_RS20350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EKD16_RS20355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EKD16_RS20360	COG1120	ATPase activity
EKD16_RS20365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EKD16_RS20370	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EKD16_RS20375	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EKD16_RS20385	COG0101	tRNA pseudouridine synthase activity
EKD16_RS20390	COG0203	ribosomal protein L17
EKD16_RS20395	COG0202	RNA polymerase activity
EKD16_RS20400	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EKD16_RS20405	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EKD16_RS20410	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EKD16_RS20415	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EKD16_RS20425	COG0024	Methionine aminopeptidase
EKD16_RS20430	COG0563	adenylate kinase activity
EKD16_RS20440	COG0200	Binds to the 23S rRNA
EKD16_RS20445	COG1841	ribosomal large subunit assembly
EKD16_RS20450	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EKD16_RS20455	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EKD16_RS20460	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EKD16_RS20465	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EKD16_RS20470	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EKD16_RS20475	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EKD16_RS20480	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EKD16_RS20485	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EKD16_RS20490	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EKD16_RS20495	COG0255	Belongs to the universal ribosomal protein uL29 family
EKD16_RS20500	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EKD16_RS20505	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EKD16_RS20510	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EKD16_RS20515	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EKD16_RS20520	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EKD16_RS20525	COG0089	rRNA binding
EKD16_RS20530	COG0088	Forms part of the polypeptide exit tunnel
EKD16_RS20535	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EKD16_RS20540	COG0051	transcription antitermination factor activity, RNA binding
EKD16_RS20545	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EKD16_RS20550	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EKD16_RS20555	COG0049	tRNA binding
EKD16_RS20560	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EKD16_RS20570	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EKD16_RS20575	COG0085	RNA polymerase activity
EKD16_RS20580	COG0222	ribosome binding
EKD16_RS20585	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EKD16_RS20595	COG0081	regulation of translation
EKD16_RS20600	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EKD16_RS20610	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EKD16_RS20620	COG0436	Aminotransferase
EKD16_RS20625	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EKD16_RS20630	COG2119	membrane
EKD16_RS20635	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EKD16_RS20645	COG2030	dehydratase
EKD16_RS20650	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EKD16_RS20665	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EKD16_RS20670	COG1668	transmembrane transport
EKD16_RS20675	COG4152	abc transporter atp-binding protein
EKD16_RS20745	COG1666	GTP binding
EKD16_RS20750	COG0501	Belongs to the peptidase M48B family
EKD16_RS20755	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EKD16_RS20755	COG0674	pyruvate-flavodoxin oxidoreductase activity
EKD16_RS20760	COG1013	pyruvate-flavodoxin oxidoreductase activity
EKD16_RS20765	COG0318	PFAM AMP-dependent synthetase and ligase
EKD16_RS20770	COG0702	epimerase
EKD16_RS20805	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EKD16_RS20820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EKD16_RS20825	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EKD16_RS20840	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EKD16_RS20855	COG0142	geranyltranstransferase activity
EKD16_RS20860	COG1007	ATP synthesis coupled electron transport
EKD16_RS20875	COG0713	ATP synthesis coupled electron transport
EKD16_RS20885	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EKD16_RS20890	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EKD16_RS20895	COG1034	ATP synthesis coupled electron transport
EKD16_RS20900	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EKD16_RS20910	COG0649	NAD binding
EKD16_RS20915	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EKD16_RS20920	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EKD16_RS20935	COG2226	methyltransferase
EKD16_RS20960	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EKD16_RS20970	COG0785	Cytochrome C biogenesis protein
EKD16_RS20975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EKD16_RS20990	COG0123	including yeast histone deacetylase and acetoin utilization protein
EKD16_RS20995	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EKD16_RS21000	COG0506	proline dehydrogenase activity
EKD16_RS21005	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EKD16_RS21010	COG1082	Xylose isomerase domain protein TIM barrel
EKD16_RS21015	COG0500	methyltransferase
EKD16_RS21020	COG2755	lipolytic protein G-D-S-L family
EKD16_RS21025	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EKD16_RS21060	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EKD16_RS21070	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EKD16_RS21075	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EKD16_RS21080	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EKD16_RS21085	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EKD16_RS21120	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EKD16_RS21125	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EKD16_RS21135	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EKD16_RS21140	COG0302	gtp cyclohydrolase
EKD16_RS21150	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EKD16_RS21155	COG0037	tRNA processing
EKD16_RS21170	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EKD16_RS21205	COG1486	melibiose metabolic process
EKD16_RS21225	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EKD16_RS21230	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EKD16_RS21235	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EKD16_RS21235	COG1754	DNA topoisomerase type I activity
EKD16_RS21265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EKD16_RS21330	COG0546	phosphoglycolate phosphatase activity
EKD16_RS21360	COG1132	(ABC) transporter
EKD16_RS21385	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EKD16_RS21445	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EKD16_RS21465	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
EKD16_RS21475	COG0180	Tryptophanyl-tRNA synthetase
EKD16_RS21480	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EKD16_RS21505	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EKD16_RS21510	COG0018	arginyl-trna synthetase
EKD16_RS21590	COG0300	oxidoreductase activity
EKD16_RS21605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EKD16_RS21610	COG0785	Cytochrome C biogenesis protein
EKD16_RS21615	COG1333	cytochrome c biogenesis protein
EKD16_RS21640	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EKD16_RS21640	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EKD16_RS21665	COG0640	Transcriptional regulator
EKD16_RS21675	COG1376	ErfK ybiS ycfS ynhG family protein
EKD16_RS21690	COG0789	Transcriptional regulator
EKD16_RS21710	COG2226	methyltransferase
EKD16_RS21715	COG0477	Major facilitator Superfamily
EKD16_RS21755	COG1131	(ABC) transporter
EKD16_RS21765	COG1595	DNA-templated transcription, initiation
EKD16_RS21770	COG2072	flavoprotein involved in K transport
EKD16_RS21795	COG0300	oxidoreductase activity
EKD16_RS21845	COG1131	(ABC) transporter
EKD16_RS21855	COG0745	RESPONSE REGULATOR receiver
EKD16_RS21860	COG2205	protein histidine kinase activity
EKD16_RS21870	COG1120	ATPase activity
EKD16_RS21875	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EKD16_RS21880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EKD16_RS21915	COG0726	polysaccharide deacetylase
EKD16_RS21925	COG0745	RESPONSE REGULATOR receiver
EKD16_RS21930	COG2205	protein histidine kinase activity
EKD16_RS21950	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EKD16_RS21955	COG0798	PFAM Bile acid sodium symporter
EKD16_RS22010	COG2197	response regulator
EKD16_RS22035	COG1742	UPF0060 membrane protein
EKD16_RS22045	COG3226	Transcriptional regulator
EKD16_RS22050	COG0110	maltose O-acetyltransferase activity
EKD16_RS22100	COG0702	epimerase
EKD16_RS22110	COG4106	trans-aconitate 2-methyltransferase activity
EKD16_RS22135	COG1733	regulation of RNA biosynthetic process
EKD16_RS22160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EKD16_RS22165	COG1414	Transcriptional regulator
EKD16_RS22170	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EKD16_RS22185	COG2182	Extracellular solute-binding protein
EKD16_RS22265	COG2197	response regulator
EKD16_RS22300	COG2755	lipolytic protein G-D-S-L family
EKD16_RS22300	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EKD16_RS22320	COG1609	Transcriptional regulator
EKD16_RS22330	COG1879	ABC-type sugar transport system periplasmic component
EKD16_RS22335	COG1129	ABC transporter
EKD16_RS22340	COG1172	Belongs to the binding-protein-dependent transport system permease family
EKD16_RS22345	COG1172	Belongs to the binding-protein-dependent transport system permease family
EKD16_RS22370	COG0714	Associated with various cellular activities
EKD16_RS22385	COG0515	serine threonine protein kinase
EKD16_RS22495	COG3103	Sh3 type 3 domain protein
EKD16_RS22495	COG0791	NLP P60 protein
EKD16_RS22495	COG1388	LysM domain
EKD16_RS22510	COG1876	peptidase activity
EKD16_RS22525	COG1309	transcriptional regulator
EKD16_RS22535	COG1136	(ABC) transporter
EKD16_RS22550	COG0246	Mannitol dehydrogenase
EKD16_RS22555	COG0477	Major facilitator Superfamily
EKD16_RS22570	COG2197	response regulator
EKD16_RS22575	COG0346	lactoylglutathione lyase activity
EKD16_RS22580	COG0400	carboxylic ester hydrolase activity
EKD16_RS22600	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EKD16_RS22635	COG4585	Histidine kinase
EKD16_RS22640	COG0406	alpha-ribazole phosphatase activity
EKD16_RS22645	COG0166	Belongs to the GPI family
EKD16_RS22650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EKD16_RS22690	COG0515	serine threonine protein kinase
EKD16_RS22695	COG2197	response regulator
EKD16_RS22700	COG4585	Histidine kinase
EKD16_RS22730	COG0515	serine threonine protein kinase
EKD16_RS22740	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EKD16_RS22740	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EKD16_RS22750	COG2124	cytochrome p450
EKD16_RS22780	COG1115	amino acid carrier protein
EKD16_RS22800	COG1733	regulation of RNA biosynthetic process
EKD16_RS22860	COG1063	alcohol dehydrogenase
EKD16_RS22865	COG3956	TIGRFAM MazG family protein
EKD16_RS22875	COG4221	oxidoreductase activity
EKD16_RS22910	COG0477	Major facilitator Superfamily
EKD16_RS22925	COG1309	transcriptional regulator
EKD16_RS22930	COG4221	oxidoreductase activity
EKD16_RS22945	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EKD16_RS22950	COG1357	PFAM Pentapeptide repeats (8 copies)
EKD16_RS22955	COG0789	Transcriptional regulator
EKD16_RS22960	COG2084	Dehydrogenase
EKD16_RS22990	COG4175	Glycine betaine
EKD16_RS22990	COG0517	IMP dehydrogenase activity
EKD16_RS23005	COG0717	Belongs to the dCTP deaminase family
EKD16_RS23025	COG4221	oxidoreductase activity
EKD16_RS23030	COG0789	Transcriptional regulator
EKD16_RS23050	COG0210	DNA helicase
EKD16_RS23140	COG1609	Transcriptional regulator
EKD16_RS23145	COG1129	ABC transporter
EKD16_RS23150	COG1172	Belongs to the binding-protein-dependent transport system permease family
EKD16_RS23170	COG0791	NLP P60 protein
EKD16_RS23220	COG0667	Aldo Keto reductase
EKD16_RS23265	COG4585	Histidine kinase
EKD16_RS23270	COG2197	response regulator
EKD16_RS23275	COG2186	Transcriptional regulator
EKD16_RS23280	COG0626	cystathionine gamma-synthase activity
EKD16_RS23285	COG1757	Na H antiporter
EKD16_RS23325	COG5297	Belongs to the glycosyl hydrolase family 6
EKD16_RS23325	COG4733	cellulase activity
EKD16_RS23330	COG5297	Belongs to the glycosyl hydrolase family 6
EKD16_RS23360	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EKD16_RS23375	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EKD16_RS23410	COG1324	tolerance protein
EKD16_RS23415	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EKD16_RS23425	COG0191	fructose-bisphosphate aldolase activity
EKD16_RS23435	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EKD16_RS23440	COG0151	Belongs to the GarS family
EKD16_RS23445	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EKD16_RS23450	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EKD16_RS23460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EKD16_RS23545	COG0438	transferase activity, transferring glycosyl groups
EKD16_RS23595	COG0318	PFAM AMP-dependent synthetase and ligase
EKD16_RS23610	COG2261	transglycosylase associated protein
EKD16_RS23620	COG1376	ErfK ybiS ycfS ynhG family protein
EKD16_RS23650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EKD16_RS23660	COG3473	Maleate cis-trans isomerase
EKD16_RS23700	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EKD16_RS23710	COG3693	PFAM glycoside hydrolase, family 10
EKD16_RS23740	COG3795	YCII-related domain
EKD16_RS23745	COG4941	Belongs to the sigma-70 factor family
EKD16_RS23755	COG2205	protein histidine kinase activity
EKD16_RS23760	COG0745	RESPONSE REGULATOR receiver
EKD16_RS23810	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
EKD16_RS23820	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EKD16_RS23825	COG0346	lactoylglutathione lyase activity
EKD16_RS23865	COG1136	(ABC) transporter
EKD16_RS23865	COG0577	efflux transmembrane transporter activity
EKD16_RS23880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EKD16_RS23885	COG4948	Mandelate Racemase Muconate Lactonizing
EKD16_RS23930	COG1131	(ABC) transporter
EKD16_RS23940	COG2197	response regulator
EKD16_RS23950	COG0385	Bile acid
EKD16_RS23955	COG0583	DNA-binding transcription factor activity
EKD16_RS23995	COG0508	dehydrogenase complex catalyzes the overall conversion of
EKD16_RS24000	COG0508	dehydrogenase complex catalyzes the overall conversion of
EKD16_RS24000	COG0022	dehydrogenase e1 component
EKD16_RS24005	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EKD16_RS24020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EKD16_RS24030	COG0259	pyridoxamine-phosphate oxidase activity
EKD16_RS24050	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EKD16_RS24080	COG0494	nUDIX hydrolase
EKD16_RS24095	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EKD16_RS24105	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EKD16_RS24115	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EKD16_RS24135	COG4152	abc transporter atp-binding protein
EKD16_RS24145	COG1396	sequence-specific DNA binding
EKD16_RS24175	COG0444	Belongs to the ABC transporter superfamily
EKD16_RS24270	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EKD16_RS24295	COG1733	regulation of RNA biosynthetic process
EKD16_RS24315	COG0305	Participates in initiation and elongation during chromosome replication
EKD16_RS24330	COG0359	binds to the 23S rRNA
EKD16_RS24335	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EKD16_RS24340	COG0629	single-stranded DNA binding
EKD16_RS24345	COG0360	Binds together with S18 to 16S ribosomal RNA
EKD16_RS24385	COG0617	tRNA 3'-terminal CCA addition
EKD16_RS24405	COG0515	serine threonine protein kinase
EKD16_RS24405	COG2815	serine threonine protein kinase
EKD16_RS24410	COG1595	DNA-templated transcription, initiation
EKD16_RS24420	COG0492	ferredoxin-NADP+ reductase activity
EKD16_RS24425	COG3118	belongs to the thioredoxin family
EKD16_RS24440	COG1192	Involved in chromosome partitioning
EKD16_RS24445	COG0357	Ribosomal RNA small subunit methyltransferase G
EKD16_RS24455	COG0706	membrane insertase activity
EKD16_RS24460	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EKD16_RS24465	COG0594	ribonuclease P activity
EKD16_RS24605	COG0113	porphobilinogen synthase activity
EKD16_RS24610	COG0181	hydroxymethylbilane synthase activity
EKD16_RS24915	COG0537	adenosine 5'-monophosphoramidase activity
EKD16_RS25130	COG1609	Transcriptional regulator