locus-tag	class	description
SAD14_RS00045	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAD14_RS00050	COG3246	L-lysine catabolic process to acetate
SAD14_RS00080	COG0477	Major facilitator Superfamily
SAD14_RS00105	COG4335	DNA alkylation repair
SAD14_RS00110	COG1349	DNA-binding transcription factor activity
SAD14_RS00120	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
SAD14_RS00120	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SAD14_RS00120	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SAD14_RS00125	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SAD14_RS00125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SAD14_RS00130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SAD14_RS00195	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SAD14_RS00225	COG1695	Transcriptional regulator
SAD14_RS00250	COG1028	Short-chain dehydrogenase reductase Sdr
SAD14_RS00265	COG0513	Belongs to the DEAD box helicase family
SAD14_RS00275	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SAD14_RS00290	COG3217	Mosc domain protein beta barrel domain protein
SAD14_RS00290	COG0633	Ferredoxin
SAD14_RS00310	COG1349	DNA-binding transcription factor activity
SAD14_RS00330	COG1940	carbohydrate kinase activity
SAD14_RS00340	COG2223	nitrite transmembrane transporter activity
SAD14_RS00355	COG2197	response regulator
SAD14_RS00370	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SAD14_RS00395	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SAD14_RS00435	COG0584	glycerophosphoryl diester phosphodiesterase
SAD14_RS00450	COG1846	Transcriptional regulator
SAD14_RS00470	COG0671	phosphoesterase, PA-phosphatase related
SAD14_RS00500	COG2233	PERMEase
SAD14_RS00505	COG0640	Transcriptional regulator
SAD14_RS00510	COG1902	pentaerythritol trinitrate reductase activity
SAD14_RS00525	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SAD14_RS00540	COG2706	6-phosphogluconolactonase activity
SAD14_RS00555	COG0071	Belongs to the small heat shock protein (HSP20) family
SAD14_RS00560	COG0076	glutamate decarboxylase activity
SAD14_RS00565	COG0243	molybdopterin cofactor binding
SAD14_RS00580	COG0303	'Molybdopterin
SAD14_RS00585	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SAD14_RS00600	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SAD14_RS00605	COG0583	DNA-binding transcription factor activity
SAD14_RS00650	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SAD14_RS00655	COG1120	ATPase activity
SAD14_RS00660	COG2207	Transcriptional regulator
SAD14_RS00665	COG2814	Major facilitator Superfamily
SAD14_RS00690	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SAD14_RS00705	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SAD14_RS00725	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SAD14_RS00745	COG0477	Major facilitator Superfamily
SAD14_RS00750	COG1309	transcriptional regulator
SAD14_RS00760	COG1472	Belongs to the glycosyl hydrolase 3 family
SAD14_RS00770	COG1175	transmembrane transport
SAD14_RS00780	COG1609	Transcriptional regulator
SAD14_RS00785	COG0432	Pfam Uncharacterised protein family UPF0047
SAD14_RS00790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SAD14_RS00795	COG1116	anion transmembrane transporter activity
SAD14_RS00805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAD14_RS00810	COG0492	ferredoxin-NADP+ reductase activity
SAD14_RS00815	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SAD14_RS00820	COG1132	(ABC) transporter
SAD14_RS00840	COG1132	(ABC) transporter
SAD14_RS00845	COG1132	(ABC) transporter
SAD14_RS00860	COG1946	Acyl-CoA thioesterase
SAD14_RS00875	COG2018	Roadblock/LC7 domain
SAD14_RS00920	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SAD14_RS01000	COG0477	Major facilitator Superfamily
SAD14_RS01010	COG0583	DNA-binding transcription factor activity
SAD14_RS01015	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SAD14_RS01020	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SAD14_RS01025	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAD14_RS01030	COG1960	acyl-CoA dehydrogenase activity
SAD14_RS01035	COG2391	methyltransferase activity
SAD14_RS01075	COG1396	sequence-specific DNA binding
SAD14_RS01080	COG0740	serine-type endopeptidase activity
SAD14_RS01085	COG0740	serine-type endopeptidase activity
SAD14_RS01120	COG4521	taurine ABC transporter
SAD14_RS01125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SAD14_RS01145	COG3959	Transketolase, thiamine diphosphate binding domain
SAD14_RS01150	COG3958	Transketolase
SAD14_RS01220	COG2755	lipolytic protein G-D-S-L family
SAD14_RS01225	COG2365	Tyrosine phosphatase family
SAD14_RS01255	COG1657	PFAM Prenyltransferase squalene oxidase
SAD14_RS01265	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SAD14_RS01275	COG1562	ergosterol biosynthetic process
SAD14_RS01280	COG1134	teichoic acid transport
SAD14_RS01280	COG1388	LysM domain
SAD14_RS01305	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SAD14_RS01320	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SAD14_RS01335	COG1024	Enoyl-CoA hydratase
SAD14_RS01350	COG2183	response to ionizing radiation
SAD14_RS01365	COG1802	Transcriptional regulator
SAD14_RS01370	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SAD14_RS01375	COG0402	S-adenosylhomocysteine deaminase activity
SAD14_RS01400	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SAD14_RS01405	COG0789	Transcriptional regulator
SAD14_RS01410	COG1024	Enoyl-CoA hydratase
SAD14_RS01410	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAD14_RS01415	COG0183	Belongs to the thiolase family
SAD14_RS01425	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SAD14_RS01430	COG1683	Conserved Protein
SAD14_RS01435	COG1515	deoxyribonuclease V activity
SAD14_RS01465	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SAD14_RS01475	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SAD14_RS01475	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SAD14_RS01485	COG0488	(ABC) transporter
SAD14_RS01505	COG0438	transferase activity, transferring glycosyl groups
SAD14_RS01545	COG0254	rRNA binding
SAD14_RS01565	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SAD14_RS01605	COG1793	dna ligase
SAD14_RS01610	COG1024	Enoyl-CoA hydratase
SAD14_RS01645	COG0789	Transcriptional regulator
SAD14_RS01690	COG1846	Transcriptional regulator
SAD14_RS01750	COG1012	belongs to the aldehyde dehydrogenase family
SAD14_RS01770	COG2814	Major facilitator Superfamily
SAD14_RS01775	COG2259	Doxx family
SAD14_RS01785	COG1869	D-ribose catabolic process
SAD14_RS01790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SAD14_RS01795	COG1172	Belongs to the binding-protein-dependent transport system permease family
SAD14_RS01800	COG1129	ABC transporter
SAD14_RS01805	COG1609	Transcriptional regulator
SAD14_RS01825	COG1295	ribonuclease BN
SAD14_RS01890	COG0673	inositol 2-dehydrogenase activity
SAD14_RS01900	COG1172	Belongs to the binding-protein-dependent transport system permease family
SAD14_RS01905	COG1129	ABC transporter
SAD14_RS01910	COG1940	carbohydrate kinase activity
SAD14_RS01915	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SAD14_RS01930	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SAD14_RS01940	COG0583	DNA-binding transcription factor activity
SAD14_RS01945	COG1115	amino acid carrier protein
SAD14_RS01970	COG2154	pterin-4-alpha-carbinolamine dehydratase
SAD14_RS02000	COG1140	nitrate reductase beta subunit
SAD14_RS02060	COG0693	protein deglycase activity
SAD14_RS02070	COG1597	lipid kinase activity
SAD14_RS02075	COG4106	trans-aconitate 2-methyltransferase activity
SAD14_RS02090	COG3226	Transcriptional regulator
SAD14_RS02100	COG0604	alcohol dehydrogenase
SAD14_RS02115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SAD14_RS02135	COG1619	proteins homologs of microcin C7 resistance protein MccF
SAD14_RS02145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SAD14_RS02170	COG0596	Alpha beta hydrolase
SAD14_RS02190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAD14_RS02195	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAD14_RS02200	COG1120	ATPase activity
SAD14_RS02205	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAD14_RS02215	COG0604	alcohol dehydrogenase
SAD14_RS02220	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SAD14_RS02220	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SAD14_RS02225	COG2301	Belongs to the HpcH HpaI aldolase family
SAD14_RS02240	COG0688	phosphatidylethanolamine metabolic process
SAD14_RS02250	COG1929	Belongs to the glycerate kinase type-1 family
SAD14_RS02255	COG0488	(ABC) transporter
SAD14_RS02265	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SAD14_RS02270	COG0702	epimerase
SAD14_RS02275	COG1028	Short-chain dehydrogenase reductase Sdr
SAD14_RS02285	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
SAD14_RS02310	COG0159	tryptophan synthase activity
SAD14_RS02325	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SAD14_RS02340	COG0483	inositol monophosphate 1-phosphatase activity
SAD14_RS02350	COG0095	Lipoate-protein ligase
SAD14_RS02370	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SAD14_RS02395	COG0405	Gamma-glutamyltransferase
SAD14_RS02425	COG0765	amino acid transport
SAD14_RS02430	COG0765	amino acid transport
SAD14_RS02435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SAD14_RS02440	COG1126	abc transporter atp-binding protein
SAD14_RS02470	COG1228	amidohydrolase
SAD14_RS02475	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SAD14_RS02490	COG1960	acyl-CoA dehydrogenase activity
SAD14_RS02520	COG2133	pyrroloquinoline quinone binding
SAD14_RS02520	COG5183	chlorophyll binding
SAD14_RS02525	COG1132	(ABC) transporter
SAD14_RS02530	COG1132	(ABC) transporter
SAD14_RS02535	COG1120	ATPase activity
SAD14_RS02540	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAD14_RS02545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAD14_RS02550	COG2375	cellular response to nickel ion
SAD14_RS02555	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SAD14_RS02560	COG2207	Transcriptional regulator
SAD14_RS02590	COG2197	response regulator
SAD14_RS02600	COG0464	growth
SAD14_RS02680	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SAD14_RS02690	COG1940	carbohydrate kinase activity
SAD14_RS02700	COG1172	Belongs to the binding-protein-dependent transport system permease family
SAD14_RS02710	COG2188	Transcriptional regulator
SAD14_RS02715	COG0673	inositol 2-dehydrogenase activity
SAD14_RS02730	COG2197	response regulator
SAD14_RS02735	COG4585	Histidine kinase
SAD14_RS02750	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SAD14_RS02755	COG1414	Transcriptional regulator
SAD14_RS02770	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SAD14_RS02775	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SAD14_RS02780	COG2080	2 iron, 2 sulfur cluster binding
SAD14_RS02785	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SAD14_RS02790	COG2197	response regulator
SAD14_RS02795	COG1309	transcriptional regulator
SAD14_RS02810	COG4941	Belongs to the sigma-70 factor family
SAD14_RS02815	COG3795	YCII-related domain
SAD14_RS02820	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SAD14_RS02825	COG1621	beta-fructofuranosidase activity
SAD14_RS02845	COG1609	Transcriptional regulator
SAD14_RS02895	COG2233	PERMEase
SAD14_RS02910	COG2351	hydroxyisourate hydrolase activity
SAD14_RS02930	COG3622	Belongs to the hyi family
SAD14_RS02935	COG2084	Dehydrogenase
SAD14_RS02940	COG0753	catalase activity
SAD14_RS02950	COG3960	tartronate-semialdehyde synthase activity
SAD14_RS02960	COG0318	PFAM AMP-dependent synthetase and ligase
SAD14_RS02965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SAD14_RS02970	COG2197	response regulator
SAD14_RS02980	COG1309	transcriptional regulator
SAD14_RS03020	COG2252	PERMEase
SAD14_RS03025	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SAD14_RS03040	COG3835	regulator
SAD14_RS03045	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SAD14_RS03055	COG1802	Transcriptional regulator
SAD14_RS03070	COG1028	Short-chain dehydrogenase reductase Sdr
SAD14_RS03085	COG0028	Belongs to the TPP enzyme family
SAD14_RS03105	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SAD14_RS03110	COG1162	GTPase activity
SAD14_RS03120	COG2365	Tyrosine phosphatase family
SAD14_RS03160	COG1595	DNA-templated transcription, initiation
SAD14_RS03170	COG0789	Transcriptional regulator
SAD14_RS03180	COG0702	epimerase
SAD14_RS03185	COG1846	Transcriptional regulator
SAD14_RS03190	COG2409	Drug exporters of the RND superfamily
SAD14_RS03200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAD14_RS03205	COG1120	ATPase activity
SAD14_RS03215	COG2255	four-way junction helicase activity
SAD14_RS03240	COG2040	homocysteine
SAD14_RS03260	COG1960	acyl-CoA dehydrogenase activity
SAD14_RS03265	COG0604	alcohol dehydrogenase
SAD14_RS03275	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SAD14_RS03290	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SAD14_RS03300	COG0175	sulfate reduction
SAD14_RS03305	COG0529	Catalyzes the synthesis of activated sulfate
SAD14_RS03330	COG1116	anion transmembrane transporter activity
SAD14_RS03335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SAD14_RS03350	COG0386	Belongs to the glutathione peroxidase family
SAD14_RS03385	COG5002	protein histidine kinase activity
SAD14_RS03385	COG2176	DNA-directed DNA polymerase activity
SAD14_RS03450	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SAD14_RS03455	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SAD14_RS03475	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SAD14_RS03480	COG1595	DNA-templated transcription, initiation
SAD14_RS03495	COG1028	Short-chain dehydrogenase reductase Sdr
SAD14_RS03505	COG0726	polysaccharide deacetylase
SAD14_RS03515	COG3220	belongs to the UPF0276 family
SAD14_RS03525	COG3253	May function as heme-dependent peroxidase
SAD14_RS03530	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SAD14_RS03540	COG0446	pyridine nucleotide-disulphide oxidoreductase
SAD14_RS03545	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SAD14_RS03565	COG0183	Belongs to the thiolase family
SAD14_RS03570	COG1024	Enoyl-CoA hydratase
SAD14_RS03570	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAD14_RS03590	COG0531	amino acid
SAD14_RS03595	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SAD14_RS03600	COG4214	carbohydrate transport
SAD14_RS03610	COG4213	ABC transporter substrate-binding protein
SAD14_RS03620	COG0395	ABC-type sugar transport system, permease component
SAD14_RS03625	COG1175	transmembrane transport
SAD14_RS03630	COG1653	transport
SAD14_RS03635	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SAD14_RS03665	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SAD14_RS03715	COG1120	ATPase activity
SAD14_RS03720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAD14_RS03725	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SAD14_RS03745	COG2235	arginine
SAD14_RS03750	COG1320	monovalent cation:proton antiporter activity
SAD14_RS03765	COG0651	ATP synthesis coupled electron transport
SAD14_RS03770	COG1006	Multisubunit Na H antiporter MnhC subunit
SAD14_RS03775	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SAD14_RS03775	COG2111	Na H antiporter
SAD14_RS03785	COG2124	cytochrome p450
SAD14_RS03815	COG0531	amino acid
SAD14_RS03820	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SAD14_RS03825	COG2235	arginine
SAD14_RS03845	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SAD14_RS03850	COG2890	protein-(glutamine-N5) methyltransferase activity
SAD14_RS03880	COG1799	cell septum assembly
SAD14_RS03890	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SAD14_RS03905	COG1556	Lactate utilization protein
SAD14_RS03910	COG1139	Iron-sulfur cluster binding protein
SAD14_RS03915	COG0247	lactate metabolic process
SAD14_RS03920	COG1620	l-lactate permease
SAD14_RS03930	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SAD14_RS03970	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SAD14_RS03980	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SAD14_RS03995	COG1120	ATPase activity
SAD14_RS04000	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAD14_RS04005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAD14_RS04015	COG1733	regulation of RNA biosynthetic process
SAD14_RS04035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SAD14_RS04040	COG0601	transmembrane transport
SAD14_RS04050	COG0747	negative chemotaxis
SAD14_RS04060	COG1309	transcriptional regulator
SAD14_RS04075	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SAD14_RS04090	COG2936	dipeptidyl-peptidase activity
SAD14_RS04110	COG3540	Alkaline phosphatase
SAD14_RS04120	COG2050	protein possibly involved in aromatic compounds catabolism
SAD14_RS04135	COG0789	Transcriptional regulator
SAD14_RS04140	COG0640	Transcriptional regulator
SAD14_RS04160	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SAD14_RS04205	COG0438	transferase activity, transferring glycosyl groups
SAD14_RS04210	COG3226	Transcriptional regulator
SAD14_RS04215	COG0738	Major facilitator superfamily
SAD14_RS04230	COG4213	ABC transporter substrate-binding protein
SAD14_RS04235	COG1172	Belongs to the binding-protein-dependent transport system permease family
SAD14_RS04240	COG1172	Belongs to the binding-protein-dependent transport system permease family
SAD14_RS04245	COG1129	ABC transporter
SAD14_RS04250	COG1940	carbohydrate kinase activity
SAD14_RS04250	COG1846	Transcriptional regulator
SAD14_RS04255	COG0252	asparaginase activity
SAD14_RS04265	COG1028	Short-chain dehydrogenase reductase Sdr
SAD14_RS04285	COG1028	Short-chain dehydrogenase reductase Sdr
SAD14_RS04300	COG1028	Short-chain dehydrogenase reductase Sdr
SAD14_RS04335	COG0473	3-isopropylmalate dehydrogenase activity
SAD14_RS04350	COG0656	L-ascorbic acid biosynthetic process
SAD14_RS04385	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SAD14_RS04410	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SAD14_RS04420	COG1127	ABC transporter
SAD14_RS04465	COG0583	DNA-binding transcription factor activity
SAD14_RS04475	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SAD14_RS04490	COG4221	oxidoreductase activity
SAD14_RS04495	COG0300	oxidoreductase activity
SAD14_RS04550	COG2233	PERMEase
SAD14_RS04555	COG0402	S-adenosylhomocysteine deaminase activity
SAD14_RS04570	COG0559	Belongs to the binding-protein-dependent transport system permease family
SAD14_RS04605	COG0395	ABC-type sugar transport system, permease component
SAD14_RS04610	COG1063	alcohol dehydrogenase
SAD14_RS04625	COG0438	transferase activity, transferring glycosyl groups
SAD14_RS04630	COG2197	response regulator
SAD14_RS04640	COG1136	(ABC) transporter
SAD14_RS04640	COG0577	efflux transmembrane transporter activity
SAD14_RS04650	COG2197	response regulator
SAD14_RS04660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SAD14_RS04665	COG0531	amino acid
SAD14_RS04670	COG0569	domain protein
SAD14_RS04700	COG1136	(ABC) transporter
SAD14_RS04720	COG0756	dUTP diphosphatase activity
SAD14_RS04745	COG2205	protein histidine kinase activity
SAD14_RS04750	COG0745	RESPONSE REGULATOR receiver
SAD14_RS04760	COG0483	inositol monophosphate 1-phosphatase activity
SAD14_RS04765	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SAD14_RS04815	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SAD14_RS04825	COG1802	Transcriptional regulator
SAD14_RS04840	COG0612	Peptidase, M16
SAD14_RS04845	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SAD14_RS04855	COG0366	Alpha amylase catalytic
SAD14_RS04860	COG0395	ABC-type sugar transport system, permease component
SAD14_RS04865	COG1175	transmembrane transport
SAD14_RS04870	COG1653	transport
SAD14_RS04885	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SAD14_RS04920	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SAD14_RS04925	COG1802	Transcriptional regulator
SAD14_RS04960	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SAD14_RS04975	COG0588	phosphoglycerate mutase activity
SAD14_RS04995	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SAD14_RS05000	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SAD14_RS05005	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SAD14_RS05045	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SAD14_RS05055	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SAD14_RS05060	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SAD14_RS05070	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SAD14_RS05090	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SAD14_RS05100	COG2205	protein histidine kinase activity
SAD14_RS05105	COG0745	RESPONSE REGULATOR receiver
SAD14_RS05110	COG1126	abc transporter atp-binding protein
SAD14_RS05115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SAD14_RS05120	COG0765	amino acid transport
SAD14_RS05125	COG0765	amino acid transport
SAD14_RS05130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SAD14_RS05140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SAD14_RS05145	COG2137	regulation of response to DNA damage stimulus
SAD14_RS05150	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SAD14_RS05175	COG0628	permease
SAD14_RS05200	COG1201	RNA secondary structure unwinding
SAD14_RS05205	COG0596	Alpha beta hydrolase
SAD14_RS05225	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SAD14_RS05235	COG0783	Belongs to the Dps family
SAD14_RS05240	COG1396	sequence-specific DNA binding
SAD14_RS05245	COG1546	Belongs to the CinA family
SAD14_RS05245	COG1058	Belongs to the CinA family
SAD14_RS05255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SAD14_RS05265	COG1674	ftsk spoiiie
SAD14_RS05275	COG2205	protein histidine kinase activity
SAD14_RS05275	COG3437	response regulator, receiver
SAD14_RS05275	COG3850	Histidine kinase
SAD14_RS05275	COG4999	Histidine kinase
SAD14_RS05280	COG2208	phosphoserine phosphatase activity
SAD14_RS05280	COG2770	Histidine kinase
SAD14_RS05310	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SAD14_RS05315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SAD14_RS05320	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SAD14_RS05340	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SAD14_RS05345	COG0612	Peptidase, M16
SAD14_RS05350	COG1185	polyribonucleotide nucleotidyltransferase activity
SAD14_RS05355	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SAD14_RS05380	COG0455	bacterial-type flagellum organization
SAD14_RS05385	COG0747	negative chemotaxis
SAD14_RS05390	COG0601	transmembrane transport
SAD14_RS05395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SAD14_RS05400	COG0444	Belongs to the ABC transporter superfamily
SAD14_RS05405	COG4608	Belongs to the ABC transporter superfamily
SAD14_RS05410	COG1357	PFAM Pentapeptide repeats (8 copies)
SAD14_RS05425	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SAD14_RS05430	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SAD14_RS05440	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SAD14_RS05455	COG0779	Required for maturation of 30S ribosomal subunits
SAD14_RS05475	COG0442	prolyl-tRNA aminoacylation
SAD14_RS05495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SAD14_RS05500	COG0601	transmembrane transport
SAD14_RS05505	COG0747	negative chemotaxis
SAD14_RS05520	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SAD14_RS05525	COG0750	zinc metalloprotease
SAD14_RS05530	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SAD14_RS05535	COG1940	carbohydrate kinase activity
SAD14_RS05540	COG1012	belongs to the aldehyde dehydrogenase family
SAD14_RS05545	COG2508	Transcriptional regulator
SAD14_RS05575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SAD14_RS05580	COG1177	transmembrane transport
SAD14_RS05585	COG1176	ABC-type spermidine putrescine transport system, permease component I
SAD14_RS05590	COG3842	ATPase activity
SAD14_RS05600	COG1012	belongs to the aldehyde dehydrogenase family
SAD14_RS05615	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SAD14_RS05635	COG1012	belongs to the aldehyde dehydrogenase family
SAD14_RS05645	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SAD14_RS05670	COG3842	ATPase activity
SAD14_RS05675	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
SAD14_RS05685	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SAD14_RS05690	COG0575	Belongs to the CDS family
SAD14_RS05695	COG0233	cytoplasmic translational termination
SAD14_RS05700	COG0528	UMP kinase activity
SAD14_RS05705	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SAD14_RS05710	COG0052	Belongs to the universal ribosomal protein uS2 family
SAD14_RS05725	COG1191	sigma factor activity
SAD14_RS05740	COG0792	nuclease activity
SAD14_RS05755	COG0681	Belongs to the peptidase S26 family
SAD14_RS05760	COG0681	Belongs to the peptidase S26 family
SAD14_RS05770	COG0681	Belongs to the peptidase S26 family
SAD14_RS05775	COG0335	large ribosomal subunit rRNA binding
SAD14_RS05780	COG0336	Belongs to the RNA methyltransferase TrmD family
SAD14_RS05785	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SAD14_RS05790	COG1837	Belongs to the UPF0109 family
SAD14_RS05795	COG0228	four-way junction DNA binding
SAD14_RS05810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SAD14_RS05820	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SAD14_RS05850	COG0477	Major facilitator Superfamily
SAD14_RS05855	COG1196	nuclear chromosome segregation
SAD14_RS05865	COG1254	Belongs to the acylphosphatase family
SAD14_RS05870	COG2340	Cysteine-rich secretory protein family
SAD14_RS05875	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SAD14_RS05880	COG0571	ribonuclease III activity
SAD14_RS05885	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SAD14_RS05900	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SAD14_RS05905	COG0742	ribosomal rna small subunit methyltransferase
SAD14_RS05915	COG1461	Dihydroxyacetone kinase
SAD14_RS05920	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SAD14_RS05925	COG0351	phosphomethylpyrimidine kinase
SAD14_RS05945	COG1181	Belongs to the D-alanine--D-alanine ligase family
SAD14_RS05950	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SAD14_RS05960	COG1920	GTP binding
SAD14_RS05970	COG0776	regulation of translation
SAD14_RS05980	COG0066	3-isopropylmalate dehydratase activity
SAD14_RS05985	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SAD14_RS05990	COG1414	Transcriptional regulator
SAD14_RS06035	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SAD14_RS06040	COG0179	Fumarylacetoacetate (FAA) hydrolase
SAD14_RS06055	COG2018	Roadblock/LC7 domain
SAD14_RS06075	COG2018	Roadblock/LC7 domain
SAD14_RS06095	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SAD14_RS06105	COG2353	YceI-like domain
SAD14_RS06145	COG0789	Transcriptional regulator
SAD14_RS06165	COG4221	oxidoreductase activity
SAD14_RS06195	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SAD14_RS06200	COG0477	Major facilitator Superfamily
SAD14_RS06205	COG2957	Belongs to the agmatine deiminase family
SAD14_RS06210	COG0804	urea catabolic process
SAD14_RS06215	COG0831	urea catabolic process
SAD14_RS06215	COG0832	Belongs to the urease beta subunit family
SAD14_RS06220	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SAD14_RS06225	COG0473	3-isopropylmalate dehydrogenase activity
SAD14_RS06255	COG1012	belongs to the aldehyde dehydrogenase family
SAD14_RS06260	COG0506	proline dehydrogenase activity
SAD14_RS06265	COG3835	regulator
SAD14_RS06285	COG2890	protein-(glutamine-N5) methyltransferase activity
SAD14_RS06295	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SAD14_RS06300	COG0440	acetolactate synthase activity
SAD14_RS06320	COG0667	Aldo Keto reductase
SAD14_RS06325	COG2133	pyrroloquinoline quinone binding
SAD14_RS06345	COG2197	response regulator
SAD14_RS06365	COG2409	Drug exporters of the RND superfamily
SAD14_RS06370	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SAD14_RS06380	COG0154	amidase activity
SAD14_RS06385	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SAD14_RS06395	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SAD14_RS06405	COG4221	oxidoreductase activity
SAD14_RS06425	COG0482	sulfurtransferase activity
SAD14_RS06450	COG2860	membrane
SAD14_RS06455	COG4608	Belongs to the ABC transporter superfamily
SAD14_RS06460	COG0444	Belongs to the ABC transporter superfamily
SAD14_RS06465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SAD14_RS06470	COG0601	transmembrane transport
SAD14_RS06475	COG0747	negative chemotaxis
SAD14_RS06495	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SAD14_RS06500	COG0509	glycine decarboxylation via glycine cleavage system
SAD14_RS06505	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SAD14_RS06510	COG1760	l-serine dehydratase
SAD14_RS06525	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SAD14_RS06530	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SAD14_RS06535	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SAD14_RS06550	COG0477	Major facilitator Superfamily
SAD14_RS06565	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SAD14_RS06590	COG2085	NADP oxidoreductase coenzyme F420-dependent
SAD14_RS06615	COG1376	ErfK ybiS ycfS ynhG family protein
SAD14_RS06640	COG1132	(ABC) transporter
SAD14_RS06645	COG1132	(ABC) transporter
SAD14_RS06655	COG1733	regulation of RNA biosynthetic process
SAD14_RS06675	COG0366	Alpha amylase catalytic
SAD14_RS06680	COG0366	Alpha amylase catalytic
SAD14_RS06685	COG3281	Trehalose synthase
SAD14_RS06690	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SAD14_RS06705	COG1119	ATPase activity
SAD14_RS06710	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SAD14_RS06725	COG1301	dicarboxylic acid transport
SAD14_RS06730	COG3290	protein histidine kinase activity
SAD14_RS06735	COG4565	transcriptional regulatory protein
SAD14_RS06740	COG0205	6-phosphofructokinase activity
SAD14_RS06745	COG0280	phosphate acetyltransferase
SAD14_RS06745	COG0857	belongs to the CobB CobQ family
SAD14_RS06750	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SAD14_RS06790	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SAD14_RS06790	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SAD14_RS06865	COG1335	isochorismatase
SAD14_RS06895	COG0183	Belongs to the thiolase family
SAD14_RS06915	COG1131	(ABC) transporter
SAD14_RS06950	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
SAD14_RS06965	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAD14_RS06980	COG4585	Histidine kinase
SAD14_RS06985	COG2197	response regulator
SAD14_RS07005	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SAD14_RS07010	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SAD14_RS07015	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SAD14_RS07020	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SAD14_RS07025	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SAD14_RS07030	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SAD14_RS07035	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SAD14_RS07050	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SAD14_RS07055	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SAD14_RS07065	COG2890	protein-(glutamine-N5) methyltransferase activity
SAD14_RS07070	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SAD14_RS07075	COG0254	rRNA binding
SAD14_RS07080	COG1316	TRANSCRIPTIONal
SAD14_RS07090	COG0083	homoserine kinase activity
SAD14_RS07095	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SAD14_RS07100	COG0460	homoserine dehydrogenase
SAD14_RS07105	COG0019	diaminopimelate decarboxylase activity
SAD14_RS07110	COG0018	arginyl-trna synthetase
SAD14_RS07135	COG1012	belongs to the aldehyde dehydrogenase family
SAD14_RS07145	COG1191	sigma factor activity
SAD14_RS07150	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SAD14_RS07150	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SAD14_RS07160	COG2267	carboxylic ester hydrolase activity
SAD14_RS07165	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SAD14_RS07180	COG0772	Belongs to the SEDS family
SAD14_RS07255	COG0726	polysaccharide deacetylase
SAD14_RS07260	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SAD14_RS07265	COG0477	Major facilitator Superfamily
SAD14_RS07280	COG1595	DNA-templated transcription, initiation
SAD14_RS07290	COG1131	(ABC) transporter
SAD14_RS07310	COG0745	RESPONSE REGULATOR receiver
SAD14_RS07315	COG2205	protein histidine kinase activity
SAD14_RS07320	COG0508	dehydrogenase complex catalyzes the overall conversion of
SAD14_RS07320	COG0567	Dehydrogenase, E1 component
SAD14_RS07350	COG2255	four-way junction helicase activity
SAD14_RS07400	COG0604	alcohol dehydrogenase
SAD14_RS07405	COG0281	malic enzyme
SAD14_RS07420	COG1126	abc transporter atp-binding protein
SAD14_RS07425	COG4106	trans-aconitate 2-methyltransferase activity
SAD14_RS07475	COG0142	geranyltranstransferase activity
SAD14_RS07485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SAD14_RS07490	COG1959	2 iron, 2 sulfur cluster binding
SAD14_RS07510	COG2515	1-aminocyclopropane-1-carboxylate deaminase
SAD14_RS07525	COG2172	sigma factor antagonist activity
SAD14_RS07540	COG1597	lipid kinase activity
SAD14_RS07560	COG0363	glucosamine-6-phosphate deaminase activity
SAD14_RS07565	COG1472	Belongs to the glycosyl hydrolase 3 family
SAD14_RS07570	COG0395	ABC-type sugar transport system, permease component
SAD14_RS07575	COG1175	transmembrane transport
SAD14_RS07580	COG2182	Extracellular solute-binding protein
SAD14_RS07585	COG2188	Transcriptional regulator
SAD14_RS07590	COG1966	Carbon starvation protein
SAD14_RS07610	COG2124	cytochrome p450
SAD14_RS07620	COG0242	peptide deformylase activity
SAD14_RS07630	COG5662	AntiSigma factor
SAD14_RS07635	COG1595	DNA-templated transcription, initiation
SAD14_RS07645	COG2135	peptidase activity
SAD14_RS07655	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SAD14_RS07665	COG2076	Multidrug Resistance protein
SAD14_RS07675	COG0483	inositol monophosphate 1-phosphatase activity
SAD14_RS07680	COG0753	catalase activity
SAD14_RS07705	COG1615	UPF0182 protein
SAD14_RS07715	COG3480	Lon protease (S16) C-terminal proteolytic domain
SAD14_RS07810	COG0210	DNA helicase
SAD14_RS07900	COG0513	Belongs to the DEAD box helicase family
SAD14_RS07910	COG1432	Conserved Protein
SAD14_RS07920	COG2095	MarC family integral membrane protein
SAD14_RS07925	COG0613	PHP domain protein
SAD14_RS07930	COG2814	Major facilitator Superfamily
SAD14_RS07940	COG0598	Magnesium transport protein CorA
SAD14_RS07980	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SAD14_RS07985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SAD14_RS07995	COG1595	DNA-templated transcription, initiation
SAD14_RS08010	COG1024	Enoyl-CoA hydratase
SAD14_RS08020	COG0519	Catalyzes the synthesis of GMP from XMP
SAD14_RS08055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SAD14_RS08085	COG0456	acetyltransferase
SAD14_RS08090	COG2912	Transglutaminase-like superfamily
SAD14_RS08100	COG1609	Transcriptional regulator
SAD14_RS08105	COG1172	Belongs to the binding-protein-dependent transport system permease family
SAD14_RS08115	COG1129	ABC transporter
SAD14_RS08120	COG1879	ABC-type sugar transport system periplasmic component
SAD14_RS08125	COG3250	beta-galactosidase activity
SAD14_RS08145	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SAD14_RS08170	COG4608	Belongs to the ABC transporter superfamily
SAD14_RS08180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SAD14_RS08185	COG0601	transmembrane transport
SAD14_RS08195	COG4608	Belongs to the ABC transporter superfamily
SAD14_RS08200	COG0444	Belongs to the ABC transporter superfamily
SAD14_RS08205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SAD14_RS08210	COG0601	transmembrane transport
SAD14_RS08220	COG1217	gtp-binding protein TYPA
SAD14_RS08275	COG1554	hydrolase, family 65, central catalytic
SAD14_RS08335	COG1028	Short-chain dehydrogenase reductase Sdr
SAD14_RS08340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAD14_RS08350	COG3473	Maleate cis-trans isomerase
SAD14_RS08370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SAD14_RS08375	COG0765	amino acid transport
SAD14_RS08380	COG0765	amino acid transport
SAD14_RS08385	COG1126	abc transporter atp-binding protein
SAD14_RS08415	COG3397	chitin binding
SAD14_RS08470	COG0673	inositol 2-dehydrogenase activity
SAD14_RS08475	COG0179	Fumarylacetoacetate (FAA) hydrolase
SAD14_RS08480	COG0706	membrane insertase activity
SAD14_RS08525	COG2271	Major facilitator Superfamily
SAD14_RS08535	COG2733	membrane
SAD14_RS08565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SAD14_RS08575	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SAD14_RS08600	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SAD14_RS08610	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SAD14_RS08615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SAD14_RS08620	COG1263	PTS System
SAD14_RS08630	COG1234	tRNA 3'-trailer cleavage
SAD14_RS08655	COG1113	amino acid transport
SAD14_RS08670	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SAD14_RS08680	COG1335	isochorismatase
SAD14_RS08715	COG0277	FAD linked oxidase domain protein
SAD14_RS08725	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SAD14_RS08735	COG1174	glycine betaine transport
SAD14_RS08740	COG0517	IMP dehydrogenase activity
SAD14_RS08740	COG1125	glycine betaine transport
SAD14_RS08745	COG1174	glycine betaine transport
SAD14_RS08795	COG1116	anion transmembrane transporter activity
SAD14_RS08830	COG3293	Transposase
SAD14_RS08835	COG2318	DinB family
SAD14_RS08870	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SAD14_RS08895	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SAD14_RS08910	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SAD14_RS08915	COG0395	ABC-type sugar transport system, permease component
SAD14_RS08920	COG1175	transmembrane transport
SAD14_RS08935	COG1678	Uncharacterized ACR, COG1678
SAD14_RS08940	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SAD14_RS08945	COG0776	regulation of translation
SAD14_RS08955	COG3973	AAA domain
SAD14_RS08955	COG3973	AAA domain
SAD14_RS09000	COG0583	DNA-binding transcription factor activity
SAD14_RS09015	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SAD14_RS09020	COG0793	Belongs to the peptidase S41A family
SAD14_RS09030	COG2884	Cell division ATP-binding protein ftsE
SAD14_RS09045	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SAD14_RS09050	COG0515	serine threonine protein kinase
SAD14_RS09055	COG0515	serine threonine protein kinase
SAD14_RS09060	COG1716	ATPase activity
SAD14_RS09070	COG1653	transport
SAD14_RS09075	COG1175	transmembrane transport
SAD14_RS09080	COG0395	ABC-type sugar transport system, permease component
SAD14_RS09085	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SAD14_RS09090	COG0438	transferase activity, transferring glycosyl groups
SAD14_RS09095	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SAD14_RS09100	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SAD14_RS09110	COG2226	methyltransferase
SAD14_RS09125	COG2902	Dehydrogenase
SAD14_RS09145	COG0583	DNA-binding transcription factor activity
SAD14_RS09160	COG0653	protein targeting
SAD14_RS09165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SAD14_RS09170	COG3214	Protein conserved in bacteria
SAD14_RS09175	COG2197	response regulator
SAD14_RS09180	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SAD14_RS09190	COG0823	Involved in the tonB-independent uptake of proteins
SAD14_RS09195	COG5002	protein histidine kinase activity
SAD14_RS09200	COG0745	RESPONSE REGULATOR receiver
SAD14_RS09205	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SAD14_RS09225	COG0714	Associated with various cellular activities
SAD14_RS09230	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
SAD14_RS09265	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SAD14_RS09275	COG1482	cell wall glycoprotein biosynthetic process
SAD14_RS09285	COG2835	tetraacyldisaccharide 4'-kinase activity
SAD14_RS09295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SAD14_RS09305	COG1620	l-lactate permease
SAD14_RS09340	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SAD14_RS09345	COG0778	Nitroreductase
SAD14_RS09345	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
SAD14_RS09375	COG1316	TRANSCRIPTIONal
SAD14_RS09395	COG1316	TRANSCRIPTIONal
SAD14_RS09400	COG3046	protein related to deoxyribodipyrimidine photolyase
SAD14_RS09450	COG0753	catalase activity
SAD14_RS09490	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SAD14_RS09500	COG2072	flavoprotein involved in K transport
SAD14_RS09525	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SAD14_RS09540	COG2205	protein histidine kinase activity
SAD14_RS09545	COG0745	RESPONSE REGULATOR receiver
SAD14_RS09550	COG3104	oligopeptide transport
SAD14_RS09560	COG1366	Belongs to the anti-sigma-factor antagonist family
SAD14_RS09565	COG1191	sigma factor activity
SAD14_RS09570	COG1228	amidohydrolase
SAD14_RS09580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SAD14_RS09600	COG0395	ABC-type sugar transport system, permease component
SAD14_RS09660	COG2755	lipolytic protein G-D-S-L family
SAD14_RS09665	COG0183	Belongs to the thiolase family
SAD14_RS09685	COG1476	TRANSCRIPTIONal
SAD14_RS09700	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
SAD14_RS09710	COG1136	(ABC) transporter
SAD14_RS09715	COG1136	(ABC) transporter
SAD14_RS09715	COG0577	efflux transmembrane transporter activity
SAD14_RS09720	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SAD14_RS09725	COG1252	NADH dehydrogenase
SAD14_RS09755	COG0148	phosphopyruvate hydratase activity
SAD14_RS09770	COG2124	cytochrome p450
SAD14_RS09810	COG1733	regulation of RNA biosynthetic process
SAD14_RS09855	COG0477	Major facilitator Superfamily
SAD14_RS09895	COG0596	Alpha beta hydrolase
SAD14_RS09905	COG1316	TRANSCRIPTIONal
SAD14_RS09925	COG0789	Transcriptional regulator
SAD14_RS09950	COG4585	Histidine kinase
SAD14_RS09960	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SAD14_RS09965	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SAD14_RS09990	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SAD14_RS09995	COG0193	aminoacyl-tRNA hydrolase activity
SAD14_RS10005	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SAD14_RS10025	COG4106	trans-aconitate 2-methyltransferase activity
SAD14_RS10035	COG2197	response regulator
SAD14_RS10040	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SAD14_RS10085	COG0488	(ABC) transporter
SAD14_RS10090	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SAD14_RS10095	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SAD14_RS10100	COG0084	hydrolase, TatD family'
SAD14_RS10180	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SAD14_RS10190	COG2409	Drug exporters of the RND superfamily
SAD14_RS10200	COG0793	Belongs to the peptidase S41A family
SAD14_RS10200	COG4946	Tricorn protease homolog
SAD14_RS10210	COG4221	oxidoreductase activity
SAD14_RS10220	COG2072	flavoprotein involved in K transport
SAD14_RS10230	COG0708	Exodeoxyribonuclease III
SAD14_RS10240	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SAD14_RS10260	COG2197	response regulator
SAD14_RS10300	COG0315	cyclic pyranopterin monophosphate synthase activity
SAD14_RS10300	COG0521	Mo-molybdopterin cofactor biosynthetic process
SAD14_RS10305	COG0315	cyclic pyranopterin monophosphate synthase activity
SAD14_RS10315	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SAD14_RS10320	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SAD14_RS10330	COG3263	regulation of cellular component size
SAD14_RS10345	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SAD14_RS10360	COG1970	mechanosensitive ion channel activity
SAD14_RS10375	COG3191	aminopeptidase activity
SAD14_RS10395	COG3384	dioxygenase
SAD14_RS10400	COG1846	Transcriptional regulator
SAD14_RS10460	COG2050	protein possibly involved in aromatic compounds catabolism
SAD14_RS10470	COG0183	Belongs to the thiolase family
SAD14_RS10475	COG1024	Enoyl-CoA hydratase
SAD14_RS10480	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAD14_RS10485	COG3396	Phenylacetate-CoA oxygenase
SAD14_RS10490	COG3460	Phenylacetate-CoA oxygenase
SAD14_RS10495	COG3396	Phenylacetate-CoA oxygenase
SAD14_RS10500	COG2151	metal-sulfur cluster biosynthetic enzyme
SAD14_RS10505	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SAD14_RS10575	COG0582	viral genome integration into host DNA
SAD14_RS10620	COG1609	Transcriptional regulator
SAD14_RS10700	COG1278	Cold shock
SAD14_RS10780	COG5297	Belongs to the glycosyl hydrolase family 6
SAD14_RS10800	COG0148	phosphopyruvate hydratase activity
SAD14_RS10815	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SAD14_RS10845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SAD14_RS10885	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SAD14_RS10885	COG0515	serine threonine protein kinase
SAD14_RS10890	COG1309	transcriptional regulator
SAD14_RS10910	COG2072	flavoprotein involved in K transport
SAD14_RS10920	COG2271	Major facilitator Superfamily
SAD14_RS10940	COG1366	Belongs to the anti-sigma-factor antagonist family
SAD14_RS11020	COG4821	SIS domain
SAD14_RS11030	COG0259	pyridoxamine-phosphate oxidase activity
SAD14_RS11050	COG1024	Enoyl-CoA hydratase
SAD14_RS11065	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SAD14_RS11100	COG0583	DNA-binding transcription factor activity
SAD14_RS11110	COG0247	lactate metabolic process
SAD14_RS11110	COG0277	FAD linked oxidase domain protein
SAD14_RS11115	COG2205	protein histidine kinase activity
SAD14_RS11135	COG2124	cytochrome p450
SAD14_RS11145	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SAD14_RS11240	COG0667	Aldo Keto reductase
SAD14_RS11265	COG2252	PERMEase
SAD14_RS11275	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SAD14_RS11300	COG2814	Major facilitator Superfamily
SAD14_RS11310	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SAD14_RS11315	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SAD14_RS11330	COG2197	response regulator
SAD14_RS11335	COG1132	(ABC) transporter
SAD14_RS11340	COG1132	(ABC) transporter
SAD14_RS11350	COG0515	serine threonine protein kinase
SAD14_RS11355	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SAD14_RS11360	COG1120	ATPase activity
SAD14_RS11365	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAD14_RS11370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAD14_RS11380	COG1295	ribonuclease BN
SAD14_RS11390	COG2124	cytochrome p450
SAD14_RS11445	COG1061	Type III restriction enzyme res subunit
SAD14_RS11480	COG0667	Aldo Keto reductase
SAD14_RS11485	COG0789	Transcriptional regulator
SAD14_RS11510	COG3973	AAA domain
SAD14_RS11560	COG4585	Histidine kinase
SAD14_RS11565	COG2197	response regulator
SAD14_RS11600	COG0406	alpha-ribazole phosphatase activity
SAD14_RS11610	COG1737	Transcriptional regulator
SAD14_RS11615	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SAD14_RS11620	COG1263	PTS System
SAD14_RS11620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SAD14_RS11625	COG0667	Aldo Keto reductase
SAD14_RS11665	COG1278	Cold shock
SAD14_RS11680	COG0463	Glycosyl transferase, family 2
SAD14_RS11705	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SAD14_RS11745	COG1105	Belongs to the carbohydrate kinase PfkB family
SAD14_RS11770	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SAD14_RS11800	COG1309	transcriptional regulator
SAD14_RS11815	COG0577	efflux transmembrane transporter activity
SAD14_RS11815	COG1136	(ABC) transporter
SAD14_RS11850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SAD14_RS11920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SAD14_RS11990	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
SAD14_RS12005	COG1366	Belongs to the anti-sigma-factor antagonist family
SAD14_RS12010	COG1366	Belongs to the anti-sigma-factor antagonist family
SAD14_RS12015	COG2172	sigma factor antagonist activity
SAD14_RS12040	COG0577	efflux transmembrane transporter activity
SAD14_RS12040	COG1136	(ABC) transporter
SAD14_RS12045	COG0577	efflux transmembrane transporter activity
SAD14_RS12105	COG4585	Histidine kinase
SAD14_RS12110	COG2197	response regulator
SAD14_RS12115	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SAD14_RS12120	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SAD14_RS12140	COG0301	tRNA thio-modification
SAD14_RS12165	COG0513	Belongs to the DEAD box helicase family
SAD14_RS12170	COG1278	Cold shock
SAD14_RS12200	COG2770	Histidine kinase
SAD14_RS12200	COG2208	phosphoserine phosphatase activity
SAD14_RS12235	COG0456	acetyltransferase
SAD14_RS12245	COG0436	Aminotransferase
SAD14_RS12255	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SAD14_RS12265	COG3486	L-lysine 6-monooxygenase (NADPH) activity
SAD14_RS12275	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SAD14_RS12275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SAD14_RS12320	COG2814	Major facilitator Superfamily
SAD14_RS12375	COG1196	nuclear chromosome segregation
SAD14_RS12440	COG3842	ATPase activity
SAD14_RS12450	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SAD14_RS12460	COG1253	flavin adenine dinucleotide binding
SAD14_RS12475	COG0215	cysteine-tRNA ligase activity
SAD14_RS12490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SAD14_RS12510	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SAD14_RS12515	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SAD14_RS12520	COG1329	Transcriptional regulator
SAD14_RS12530	COG0745	RESPONSE REGULATOR receiver
SAD14_RS12535	COG5002	protein histidine kinase activity
SAD14_RS12550	COG2076	Multidrug Resistance protein
SAD14_RS12575	COG3311	Transcriptional regulator
SAD14_RS12630	COG2264	protein methyltransferase activity
SAD14_RS12635	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SAD14_RS12670	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SAD14_RS12690	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SAD14_RS12695	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SAD14_RS12725	COG4942	peptidase
SAD14_RS12730	COG0783	Belongs to the Dps family
SAD14_RS12735	COG1120	ATPase activity
SAD14_RS12740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAD14_RS12760	COG5001	Diguanylate cyclase
SAD14_RS12775	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SAD14_RS12780	COG0793	Belongs to the peptidase S41A family
SAD14_RS12800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SAD14_RS12805	COG1316	TRANSCRIPTIONal
SAD14_RS12815	COG0640	Transcriptional regulator
SAD14_RS12825	COG1252	NADH dehydrogenase
SAD14_RS12855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SAD14_RS12865	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SAD14_RS12875	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SAD14_RS12915	COG2186	Transcriptional regulator
SAD14_RS12925	COG0318	PFAM AMP-dependent synthetase and ligase
SAD14_RS12930	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SAD14_RS12930	COG0825	malonyl-CoA metabolic process
SAD14_RS12940	COG0789	Transcriptional regulator
SAD14_RS12955	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SAD14_RS12960	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SAD14_RS12975	COG0789	Transcriptional regulator
SAD14_RS12995	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SAD14_RS13010	COG2197	response regulator
SAD14_RS13040	COG2249	NAD(P)H dehydrogenase (quinone) activity
SAD14_RS13055	COG0537	adenosine 5'-monophosphoramidase activity
SAD14_RS13105	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SAD14_RS13190	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SAD14_RS13195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SAD14_RS13195	COG1754	DNA topoisomerase type I activity
SAD14_RS13205	COG2890	protein-(glutamine-N5) methyltransferase activity
SAD14_RS13220	COG1366	Belongs to the anti-sigma-factor antagonist family
SAD14_RS13225	COG1111	helicase
SAD14_RS13225	COG1205	dead DEAH box helicase
SAD14_RS13285	COG0659	secondary active sulfate transmembrane transporter activity
SAD14_RS13290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SAD14_RS13295	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SAD14_RS13305	COG2267	carboxylic ester hydrolase activity
SAD14_RS13335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SAD14_RS13345	COG0251	oxidation-reduction process
SAD14_RS13360	COG0003	Pfam Anion-transporting ATPase
SAD14_RS13380	COG1408	metallophosphoesterase
SAD14_RS13395	COG1136	(ABC) transporter
SAD14_RS13395	COG0577	efflux transmembrane transporter activity
SAD14_RS13410	COG2318	DinB family
SAD14_RS13435	COG0596	Alpha beta hydrolase
SAD14_RS13455	COG2130	NADP-dependent
SAD14_RS13500	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SAD14_RS13505	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SAD14_RS13570	COG1733	regulation of RNA biosynthetic process
SAD14_RS13580	COG0666	response to abiotic stimulus
SAD14_RS13595	COG2197	response regulator
SAD14_RS13670	COG0596	Alpha beta hydrolase
SAD14_RS13745	COG0366	Alpha amylase catalytic
SAD14_RS13745	COG1470	cell adhesion involved in biofilm formation
SAD14_RS13760	COG0579	oxidoreductase
SAD14_RS13765	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SAD14_RS13775	COG0667	Aldo Keto reductase
SAD14_RS13805	COG0542	response to heat
SAD14_RS13835	COG0513	Belongs to the DEAD box helicase family
SAD14_RS13870	COG1643	Atp-dependent helicase
SAD14_RS13905	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SAD14_RS13920	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SAD14_RS13925	COG0047	phosphoribosylformylglycinamidine synthase activity
SAD14_RS13930	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SAD14_RS13965	COG2197	response regulator
SAD14_RS13975	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SAD14_RS13990	COG0151	Belongs to the GarS family
SAD14_RS14015	COG0659	secondary active sulfate transmembrane transporter activity
SAD14_RS14025	COG2837	iron assimilation
SAD14_RS14030	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SAD14_RS14100	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SAD14_RS14135	COG1191	sigma factor activity
SAD14_RS14140	COG1191	sigma factor activity
SAD14_RS14155	COG0477	Major facilitator Superfamily
SAD14_RS14175	COG0477	Major facilitator Superfamily
SAD14_RS14185	COG0745	RESPONSE REGULATOR receiver
SAD14_RS14220	COG0318	PFAM AMP-dependent synthetase and ligase
SAD14_RS14225	COG1595	DNA-templated transcription, initiation
SAD14_RS14245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SAD14_RS14260	COG0653	protein targeting
SAD14_RS14275	COG0006	proline dipeptidase activity
SAD14_RS14295	COG1999	signal sequence binding
SAD14_RS14310	COG2837	iron assimilation
SAD14_RS14315	COG0077	Prephenate dehydratase
SAD14_RS14320	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SAD14_RS14325	COG0561	phosphatase activity
SAD14_RS14345	COG1131	(ABC) transporter
SAD14_RS14365	COG0561	phosphatase activity
SAD14_RS14370	COG0739	heme binding
SAD14_RS14370	COG0741	lytic transglycosylase activity
SAD14_RS14370	COG1196	nuclear chromosome segregation
SAD14_RS14380	COG4988	ABC transporter
SAD14_RS14385	COG1294	oxidase, subunit
SAD14_RS14390	COG1271	oxidase subunit
SAD14_RS14395	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SAD14_RS14400	COG1609	Transcriptional regulator
SAD14_RS14415	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SAD14_RS14440	COG0662	Cupin 2, conserved barrel domain protein
SAD14_RS14445	COG1950	PFAM Membrane protein of
SAD14_RS14450	COG0626	cystathionine gamma-synthase activity
SAD14_RS14495	COG0110	maltose O-acetyltransferase activity
SAD14_RS14500	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SAD14_RS14590	COG0305	Participates in initiation and elongation during chromosome replication
SAD14_RS14600	COG0359	binds to the 23S rRNA
SAD14_RS14605	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SAD14_RS14610	COG0629	single-stranded DNA binding
SAD14_RS14615	COG0360	Binds together with S18 to 16S ribosomal RNA
SAD14_RS14640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SAD14_RS14665	COG0617	tRNA 3'-terminal CCA addition
SAD14_RS14680	COG0515	serine threonine protein kinase
SAD14_RS14680	COG2815	serine threonine protein kinase
SAD14_RS14685	COG1595	DNA-templated transcription, initiation
SAD14_RS14695	COG0492	ferredoxin-NADP+ reductase activity
SAD14_RS14700	COG3118	belongs to the thioredoxin family
SAD14_RS14715	COG1192	Involved in chromosome partitioning
SAD14_RS14720	COG0357	Ribosomal RNA small subunit methyltransferase G
SAD14_RS14730	COG0706	membrane insertase activity
SAD14_RS14735	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SAD14_RS14740	COG0594	ribonuclease P activity
SAD14_RS14745	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SAD14_RS14750	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SAD14_RS14755	COG0592	DNA-directed DNA polymerase activity
SAD14_RS14760	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SAD14_RS14765	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SAD14_RS14770	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
SAD14_RS14775	COG0187	DNA topoisomerase II activity
SAD14_RS14780	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SAD14_RS14820	COG0515	serine threonine protein kinase
SAD14_RS14850	COG1278	Cold shock
SAD14_RS14855	COG1309	transcriptional regulator
SAD14_RS14875	COG0705	Rhomboid family
SAD14_RS14900	COG3764	Sortase (surface protein transpeptidase)
SAD14_RS14905	COG3764	Sortase (surface protein transpeptidase)
SAD14_RS14910	COG0515	serine threonine protein kinase
SAD14_RS14930	COG1716	ATPase activity
SAD14_RS14935	COG1716	ATPase activity
SAD14_RS14945	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SAD14_RS14950	COG1733	regulation of RNA biosynthetic process
SAD14_RS14990	COG1522	sequence-specific DNA binding
SAD14_RS15015	COG0303	'Molybdopterin
SAD14_RS15020	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SAD14_RS15045	COG0515	serine threonine protein kinase
SAD14_RS15050	COG0515	serine threonine protein kinase
SAD14_RS15065	COG0022	dehydrogenase e1 component
SAD14_RS15070	COG0508	dehydrogenase complex catalyzes the overall conversion of
SAD14_RS15125	COG1362	aminopeptidase activity
SAD14_RS15145	COG1960	acyl-CoA dehydrogenase activity
SAD14_RS15155	COG1741	Belongs to the pirin family
SAD14_RS15160	COG0628	permease
SAD14_RS15170	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SAD14_RS15180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SAD14_RS15220	COG1316	TRANSCRIPTIONal
SAD14_RS15235	COG2268	Band 7 protein
SAD14_RS15240	COG1937	Protein conserved in bacteria
SAD14_RS15245	COG1064	alcohol dehydrogenase
SAD14_RS15250	COG2770	Histidine kinase
SAD14_RS15250	COG2208	phosphoserine phosphatase activity
SAD14_RS15280	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SAD14_RS15300	COG0477	Major facilitator Superfamily
SAD14_RS15325	COG0657	acetylesterase activity
SAD14_RS15330	COG0247	lactate metabolic process
SAD14_RS15330	COG2181	nitrate reductase activity
SAD14_RS15335	COG1434	Gram-negative-bacterium-type cell wall biogenesis
SAD14_RS15375	COG0717	Belongs to the dCTP deaminase family
SAD14_RS15385	COG0326	Molecular chaperone. Has ATPase activity
SAD14_RS15405	COG2814	Major facilitator Superfamily
SAD14_RS15420	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
SAD14_RS15440	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SAD14_RS15450	COG1131	(ABC) transporter
SAD14_RS15455	COG1725	Transcriptional regulator
SAD14_RS15490	COG0443	Heat shock 70 kDa protein
SAD14_RS15495	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SAD14_RS15500	COG0484	heat shock protein binding
SAD14_RS15505	COG0789	Transcriptional regulator
SAD14_RS15530	COG0477	Major facilitator Superfamily
SAD14_RS15545	COG2378	regulation of single-species biofilm formation
SAD14_RS15595	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SAD14_RS15610	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SAD14_RS15615	COG0191	fructose-bisphosphate aldolase activity
SAD14_RS15620	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SAD14_RS15625	COG0477	Major facilitator Superfamily
SAD14_RS15645	COG3844	kynureninase activity
SAD14_RS15655	COG0702	epimerase
SAD14_RS15660	COG4585	Histidine kinase
SAD14_RS15665	COG2197	response regulator
SAD14_RS15675	COG1335	isochorismatase
SAD14_RS15690	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SAD14_RS15705	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SAD14_RS15710	COG0798	PFAM Bile acid sodium symporter
SAD14_RS15730	COG2124	cytochrome p450
SAD14_RS15735	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SAD14_RS15740	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SAD14_RS15750	COG0477	Major facilitator Superfamily
SAD14_RS15800	COG0509	glycine decarboxylation via glycine cleavage system
SAD14_RS15810	COG2318	DinB family
SAD14_RS15830	COG1196	nuclear chromosome segregation
SAD14_RS15830	COG0739	heme binding
SAD14_RS15830	COG0741	lytic transglycosylase activity
SAD14_RS15835	COG0671	phosphoesterase, PA-phosphatase related
SAD14_RS15850	COG1028	Short-chain dehydrogenase reductase Sdr
SAD14_RS15860	COG1937	Protein conserved in bacteria
SAD14_RS15870	COG0306	phosphate transporter
SAD14_RS15875	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SAD14_RS15895	COG0406	alpha-ribazole phosphatase activity
SAD14_RS15895	COG0494	nUDIX hydrolase
SAD14_RS15930	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SAD14_RS15935	COG2318	DinB family
SAD14_RS15975	COG2208	phosphoserine phosphatase activity
SAD14_RS15975	COG2770	Histidine kinase
SAD14_RS15985	COG0596	Alpha beta hydrolase
SAD14_RS15990	COG3903	Transcriptional regulator
SAD14_RS15990	COG3629	intracellular signal transduction
SAD14_RS16030	COG1595	DNA-templated transcription, initiation
SAD14_RS16085	COG2267	carboxylic ester hydrolase activity
SAD14_RS16120	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SAD14_RS16130	COG1131	(ABC) transporter
SAD14_RS16140	COG1725	Transcriptional regulator
SAD14_RS16145	COG4941	Belongs to the sigma-70 factor family
SAD14_RS16195	COG0456	acetyltransferase
SAD14_RS16200	COG0737	Belongs to the 5'-nucleotidase family
SAD14_RS16205	COG0235	Class ii aldolase
SAD14_RS16210	COG2160	L-arabinose isomerase activity
SAD14_RS16220	COG1609	Transcriptional regulator
SAD14_RS16230	COG1129	ABC transporter
SAD14_RS16235	COG4214	carbohydrate transport
SAD14_RS16250	COG0745	RESPONSE REGULATOR receiver
SAD14_RS16255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SAD14_RS16260	COG1609	Transcriptional regulator
SAD14_RS16265	COG0745	RESPONSE REGULATOR receiver
SAD14_RS16290	COG2897	thiosulfate sulfurtransferase activity
SAD14_RS16325	COG3485	protocatechuate 3,4-dioxygenase
SAD14_RS16330	COG0735	belongs to the Fur family
SAD14_RS16335	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SAD14_RS16340	COG1490	D-aminoacyl-tRNA deacylase activity
SAD14_RS16355	COG0789	Transcriptional regulator
SAD14_RS16360	COG2249	NAD(P)H dehydrogenase (quinone) activity
SAD14_RS16375	COG1476	TRANSCRIPTIONal
SAD14_RS16410	COG4106	trans-aconitate 2-methyltransferase activity
SAD14_RS16430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SAD14_RS16440	COG2226	methyltransferase
SAD14_RS16460	COG1309	transcriptional regulator
SAD14_RS16515	COG0457	Tetratricopeptide repeat
SAD14_RS16540	COG3103	Sh3 type 3 domain protein
SAD14_RS16540	COG0791	NLP P60 protein
SAD14_RS16540	COG1388	LysM domain
SAD14_RS16550	COG0438	transferase activity, transferring glycosyl groups
SAD14_RS16575	COG0588	phosphoglycerate mutase activity
SAD14_RS16600	COG0739	heme binding
SAD14_RS16615	COG0477	Major facilitator Superfamily
SAD14_RS16615	COG2814	Major facilitator Superfamily
SAD14_RS16630	COG2159	amidohydrolase
SAD14_RS16635	COG2828	Protein conserved in bacteria
SAD14_RS16640	COG2186	Transcriptional regulator
SAD14_RS16670	COG0501	Belongs to the peptidase M48B family
SAD14_RS16675	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SAD14_RS16675	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SAD14_RS16720	COG1289	transmembrane transporter activity
SAD14_RS16745	COG1012	belongs to the aldehyde dehydrogenase family
SAD14_RS16750	COG2318	DinB family
SAD14_RS16760	COG0655	NAD(P)H dehydrogenase (quinone) activity
SAD14_RS16765	COG0789	Transcriptional regulator
SAD14_RS16770	COG0586	Pfam SNARE associated Golgi protein
SAD14_RS16780	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SAD14_RS16785	COG2027	D-alanyl-D-alanine carboxypeptidase
SAD14_RS16795	COG0037	tRNA processing
SAD14_RS16810	COG0302	gtp cyclohydrolase
SAD14_RS16820	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SAD14_RS16825	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SAD14_RS16840	COG1125	glycine betaine transport
SAD14_RS16840	COG0517	IMP dehydrogenase activity
SAD14_RS16845	COG1174	glycine betaine transport
SAD14_RS16850	COG1174	glycine betaine transport
SAD14_RS16855	COG1732	Glycine betaine
SAD14_RS16865	COG0477	Major facilitator Superfamily
SAD14_RS16880	COG0477	Major facilitator Superfamily
SAD14_RS16920	COG1012	belongs to the aldehyde dehydrogenase family
SAD14_RS16940	COG4585	Histidine kinase
SAD14_RS16945	COG2197	response regulator
SAD14_RS16965	COG0649	NAD binding
SAD14_RS16980	COG2197	response regulator
SAD14_RS16995	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SAD14_RS17000	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SAD14_RS17010	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SAD14_RS17030	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SAD14_RS17055	COG0739	heme binding
SAD14_RS17060	COG2205	protein histidine kinase activity
SAD14_RS17065	COG0745	RESPONSE REGULATOR receiver
SAD14_RS17075	COG1595	DNA-templated transcription, initiation
SAD14_RS17085	COG0671	phosphoesterase, PA-phosphatase related
SAD14_RS17095	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
SAD14_RS17130	COG0248	Ppx GppA phosphatase
SAD14_RS17140	COG1082	Xylose isomerase domain protein TIM barrel
SAD14_RS17145	COG1309	transcriptional regulator
SAD14_RS17150	COG0129	dihydroxy-acid dehydratase activity
SAD14_RS17160	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SAD14_RS17180	COG0842	Transport permease protein
SAD14_RS17180	COG1129	ABC transporter
SAD14_RS17190	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SAD14_RS17195	COG0180	Tryptophanyl-tRNA synthetase
SAD14_RS17220	COG2223	nitrite transmembrane transporter activity
SAD14_RS17225	COG0123	including yeast histone deacetylase and acetoin utilization protein
SAD14_RS17255	COG4552	Acetyltransferase involved in intracellular survival and related
SAD14_RS17280	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SAD14_RS17285	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SAD14_RS17290	COG0181	hydroxymethylbilane synthase activity
SAD14_RS17295	COG1648	precorrin-2 dehydrogenase activity
SAD14_RS17295	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SAD14_RS17300	COG0113	porphobilinogen synthase activity
SAD14_RS17320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SAD14_RS17325	COG0018	arginyl-trna synthetase
SAD14_RS17330	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
SAD14_RS17355	COG1690	Belongs to the RtcB family
SAD14_RS17360	COG0659	secondary active sulfate transmembrane transporter activity
SAD14_RS17405	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SAD14_RS17410	COG0406	alpha-ribazole phosphatase activity
SAD14_RS17420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SAD14_RS17425	COG0785	Cytochrome C biogenesis protein
SAD14_RS17435	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SAD14_RS17450	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SAD14_RS17455	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SAD14_RS17460	COG0163	prenyltransferase activity
SAD14_RS17475	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SAD14_RS17495	COG1301	dicarboxylic acid transport
SAD14_RS17510	COG1131	(ABC) transporter
SAD14_RS17515	COG3559	Exporter of polyketide antibiotics
SAD14_RS17545	COG0183	Belongs to the thiolase family
SAD14_RS17555	COG1278	Cold shock
SAD14_RS17560	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SAD14_RS17680	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
SAD14_RS17740	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SAD14_RS17750	COG2226	methyltransferase
SAD14_RS17775	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAD14_RS17780	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAD14_RS17785	COG0649	NAD binding
SAD14_RS17795	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SAD14_RS17800	COG1034	ATP synthesis coupled electron transport
SAD14_RS17805	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SAD14_RS17810	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAD14_RS17815	COG0839	Belongs to the complex I subunit 6 family
SAD14_RS17820	COG0713	ATP synthesis coupled electron transport
SAD14_RS17825	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SAD14_RS17835	COG1007	ATP synthesis coupled electron transport
SAD14_RS17840	COG0514	ATP-dependent DNA helicase (RecQ)
SAD14_RS17860	COG0561	phosphatase activity
SAD14_RS17870	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SAD14_RS17885	COG3104	oligopeptide transport
SAD14_RS17890	COG0142	geranyltranstransferase activity
SAD14_RS17950	COG0488	(ABC) transporter
SAD14_RS17960	COG0702	epimerase
SAD14_RS17965	COG1733	regulation of RNA biosynthetic process
SAD14_RS17970	COG1013	pyruvate-flavodoxin oxidoreductase activity
SAD14_RS17975	COG0674	pyruvate-flavodoxin oxidoreductase activity
SAD14_RS17975	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SAD14_RS17980	COG2197	response regulator
SAD14_RS17985	COG4585	Histidine kinase
SAD14_RS17995	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAD14_RS18000	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAD14_RS18005	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAD14_RS18010	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SAD14_RS18015	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAD14_RS18020	COG0839	Belongs to the complex I subunit 6 family
SAD14_RS18025	COG0713	ATP synthesis coupled electron transport
SAD14_RS18030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SAD14_RS18040	COG1007	ATP synthesis coupled electron transport
SAD14_RS18045	COG0501	Belongs to the peptidase M48B family
SAD14_RS18050	COG3304	Inner membrane component domain
SAD14_RS18055	COG2261	transglycosylase associated protein
SAD14_RS18060	COG1666	GTP binding
SAD14_RS18075	COG0702	epimerase
SAD14_RS18080	COG0402	S-adenosylhomocysteine deaminase activity
SAD14_RS18095	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SAD14_RS18100	COG2030	dehydratase
SAD14_RS18110	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SAD14_RS18120	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SAD14_RS18125	COG0436	Aminotransferase
SAD14_RS18150	COG0081	regulation of translation
SAD14_RS18160	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SAD14_RS18165	COG0222	ribosome binding
SAD14_RS18170	COG0085	RNA polymerase activity
SAD14_RS18175	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SAD14_RS18210	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SAD14_RS18215	COG0049	tRNA binding
SAD14_RS18220	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SAD14_RS18240	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SAD14_RS18250	COG0051	transcription antitermination factor activity, RNA binding
SAD14_RS18255	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SAD14_RS18260	COG0088	Forms part of the polypeptide exit tunnel
SAD14_RS18265	COG0089	rRNA binding
SAD14_RS18270	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SAD14_RS18275	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SAD14_RS18280	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SAD14_RS18285	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SAD14_RS18290	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SAD14_RS18295	COG0255	Belongs to the universal ribosomal protein uL29 family
SAD14_RS18300	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SAD14_RS18305	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SAD14_RS18310	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SAD14_RS18315	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SAD14_RS18320	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SAD14_RS18325	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SAD14_RS18330	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SAD14_RS18335	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SAD14_RS18340	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SAD14_RS18345	COG1841	ribosomal large subunit assembly
SAD14_RS18350	COG0200	Binds to the 23S rRNA
SAD14_RS18355	COG0201	protein transport
SAD14_RS18360	COG0563	adenylate kinase activity
SAD14_RS18370	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SAD14_RS18375	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SAD14_RS18380	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SAD14_RS18385	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SAD14_RS18395	COG0203	ribosomal protein L17
SAD14_RS18400	COG0101	tRNA pseudouridine synthase activity
SAD14_RS18410	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SAD14_RS18415	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SAD14_RS18420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SAD14_RS18425	COG1072	(Pantothenic acid kinase))
SAD14_RS18440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SAD14_RS18455	COG4977	sequence-specific DNA binding
SAD14_RS18470	COG0736	holo-[acyl-carrier-protein] synthase activity
SAD14_RS18535	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SAD14_RS18540	COG2267	carboxylic ester hydrolase activity
SAD14_RS18545	COG0802	atpase or kinase
SAD14_RS18570	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SAD14_RS18605	COG0726	polysaccharide deacetylase
SAD14_RS18620	COG4221	oxidoreductase activity
SAD14_RS18625	COG0583	DNA-binding transcription factor activity
SAD14_RS18635	COG2197	response regulator
SAD14_RS18640	COG1595	DNA-templated transcription, initiation
SAD14_RS18650	COG0516	GMP reductase activity
SAD14_RS18660	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SAD14_RS18700	COG1012	belongs to the aldehyde dehydrogenase family
SAD14_RS18720	COG0519	Catalyzes the synthesis of GMP from XMP
SAD14_RS18720	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SAD14_RS18730	COG1028	Short-chain dehydrogenase reductase Sdr
SAD14_RS18770	COG2197	response regulator
SAD14_RS18775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SAD14_RS18820	COG0456	acetyltransferase
SAD14_RS18820	COG1846	Transcriptional regulator
SAD14_RS18830	COG1228	amidohydrolase
SAD14_RS18850	COG0791	NLP P60 protein
SAD14_RS18890	COG2066	Belongs to the glutaminase family
SAD14_RS18895	COG1196	nuclear chromosome segregation
SAD14_RS18895	COG0739	heme binding
SAD14_RS18895	COG0741	lytic transglycosylase activity
SAD14_RS18900	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
SAD14_RS18905	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SAD14_RS18905	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SAD14_RS18920	COG0714	Associated with various cellular activities
SAD14_RS18925	COG2425	protein containing a von Willebrand factor type A (vWA) domain
SAD14_RS18930	COG3552	Protein containing von Willebrand factor type A (VWA) domain
SAD14_RS18935	COG0045	succinate-CoA ligase (ADP-forming) activity
SAD14_RS18965	COG0138	bifunctional purine biosynthesis protein purh
SAD14_RS18975	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SAD14_RS19000	COG0039	L-malate dehydrogenase activity
SAD14_RS19020	COG1012	belongs to the aldehyde dehydrogenase family
SAD14_RS19030	COG0517	IMP dehydrogenase activity
SAD14_RS19030	COG4175	Glycine betaine
SAD14_RS19060	COG0395	ABC-type sugar transport system, permease component
SAD14_RS19065	COG1175	transmembrane transport
SAD14_RS19085	COG2362	D-Aminopeptidase
SAD14_RS19090	COG1609	Transcriptional regulator
SAD14_RS19100	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SAD14_RS19105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SAD14_RS19115	COG0754	glutathionylspermidine amidase activity
SAD14_RS19125	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SAD14_RS19165	COG0180	Tryptophanyl-tRNA synthetase
SAD14_RS19210	COG1295	ribonuclease BN
SAD14_RS19225	COG1408	metallophosphoesterase
SAD14_RS19260	COG1309	transcriptional regulator
SAD14_RS19275	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SAD14_RS19280	COG1053	succinate dehydrogenase
SAD14_RS19290	COG2009	succinate dehydrogenase
SAD14_RS19330	COG1215	transferase activity, transferring glycosyl groups
SAD14_RS19335	COG1595	DNA-templated transcription, initiation
SAD14_RS19375	COG1216	Glycosyl transferase, family 2
SAD14_RS19385	COG1083	cytidylyl-transferase
SAD14_RS19390	COG2089	acid synthase
SAD14_RS19400	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SAD14_RS19400	COG1473	amidohydrolase
SAD14_RS19445	COG1744	ABC transporter substrate-binding protein PnrA-like
SAD14_RS19450	COG3845	ABC transporter
SAD14_RS19455	COG4603	Belongs to the binding-protein-dependent transport system permease family
SAD14_RS19460	COG1079	Belongs to the binding-protein-dependent transport system permease family
SAD14_RS19500	COG2814	Major facilitator Superfamily
SAD14_RS19505	COG0583	DNA-binding transcription factor activity
SAD14_RS19530	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SAD14_RS19555	COG2205	protein histidine kinase activity
SAD14_RS19560	COG0745	RESPONSE REGULATOR receiver
SAD14_RS19565	COG1595	DNA-templated transcription, initiation
SAD14_RS19615	COG1012	belongs to the aldehyde dehydrogenase family
SAD14_RS19635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SAD14_RS19675	COG4770	biotin carboxylase activity
SAD14_RS19685	COG0424	maF-like protein
SAD14_RS19700	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SAD14_RS19710	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SAD14_RS19715	COG1024	Enoyl-CoA hydratase
SAD14_RS19725	COG2986	histidine ammonia-lyase
SAD14_RS19745	COG1136	(ABC) transporter
SAD14_RS19750	COG1064	alcohol dehydrogenase
SAD14_RS19755	COG2318	DinB family
SAD14_RS19780	COG2255	four-way junction helicase activity
SAD14_RS19785	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SAD14_RS19800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SAD14_RS19810	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SAD14_RS19845	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SAD14_RS19870	COG1331	Highly conserved protein containing a thioredoxin domain
SAD14_RS19890	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
SAD14_RS19920	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SAD14_RS19935	COG1414	Transcriptional regulator
SAD14_RS19940	COG0251	oxidation-reduction process
SAD14_RS20020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SAD14_RS20055	COG2894	cell division
SAD14_RS20120	COG2814	Major facilitator Superfamily
SAD14_RS20125	COG0656	L-ascorbic acid biosynthetic process
SAD14_RS20130	COG2304	oxidoreductase activity
SAD14_RS20140	COG3548	integral membrane protein
SAD14_RS20150	COG0667	Aldo Keto reductase
SAD14_RS20155	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SAD14_RS20160	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SAD14_RS20180	COG0450	alkyl hydroperoxide reductase
SAD14_RS20185	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SAD14_RS20195	COG1136	(ABC) transporter
SAD14_RS20215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SAD14_RS20230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SAD14_RS20240	COG0114	fumarate hydratase activity
SAD14_RS20250	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SAD14_RS20250	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SAD14_RS20260	COG0515	serine threonine protein kinase
SAD14_RS20285	COG0778	Nitroreductase
SAD14_RS20290	COG1722	exodeoxyribonuclease VII activity
SAD14_RS20295	COG1570	exodeoxyribonuclease VII activity
SAD14_RS20300	COG0531	amino acid
SAD14_RS20305	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SAD14_RS20320	COG0012	GTP binding
SAD14_RS20355	COG0709	Synthesizes selenophosphate from selenide and ATP
SAD14_RS20390	COG0406	alpha-ribazole phosphatase activity
SAD14_RS20415	COG0745	RESPONSE REGULATOR receiver
SAD14_RS20485	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
SAD14_RS20490	COG4977	sequence-specific DNA binding
SAD14_RS20505	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SAD14_RS20530	COG3486	L-lysine 6-monooxygenase (NADPH) activity
SAD14_RS20560	COG1028	Short-chain dehydrogenase reductase Sdr
SAD14_RS20570	COG3655	Transcriptional regulator
SAD14_RS20630	COG1960	acyl-CoA dehydrogenase activity
SAD14_RS20645	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SAD14_RS20650	COG1309	transcriptional regulator
SAD14_RS20660	COG1946	Acyl-CoA thioesterase
SAD14_RS20700	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SAD14_RS20710	COG3960	tartronate-semialdehyde synthase activity
SAD14_RS20730	COG1472	Belongs to the glycosyl hydrolase 3 family
SAD14_RS20735	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SAD14_RS20780	COG3718	enzyme involved in inositol metabolism
SAD14_RS20785	COG3962	Belongs to the TPP enzyme family
SAD14_RS20800	COG1131	(ABC) transporter
SAD14_RS20830	COG3629	intracellular signal transduction
SAD14_RS20830	COG3903	Transcriptional regulator
SAD14_RS20905	COG0629	single-stranded DNA binding
SAD14_RS20940	COG1136	(ABC) transporter
SAD14_RS20960	COG0667	Aldo Keto reductase
SAD14_RS20965	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SAD14_RS20995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SAD14_RS21020	COG1486	melibiose metabolic process
SAD14_RS21030	COG0668	transmembrane transport
SAD14_RS21045	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SAD14_RS21065	COG0583	DNA-binding transcription factor activity
SAD14_RS21095	COG4266	Belongs to the allantoicase family
SAD14_RS21130	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SAD14_RS21135	COG0076	glutamate decarboxylase activity
SAD14_RS21140	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SAD14_RS21145	COG1113	amino acid transport
SAD14_RS21150	COG1113	amino acid transport
SAD14_RS21155	COG1268	BioY protein
SAD14_RS21160	COG1113	amino acid transport
SAD14_RS21175	COG4552	Acetyltransferase involved in intracellular survival and related
SAD14_RS21185	COG0475	glutathione-regulated potassium exporter activity
SAD14_RS21190	COG3594	Acyltransferase
SAD14_RS21210	COG0544	peptidyl-prolyl cis-trans isomerase activity
SAD14_RS21215	COG0740	serine-type endopeptidase activity
SAD14_RS21220	COG0740	serine-type endopeptidase activity
SAD14_RS21225	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SAD14_RS21235	COG0525	valine-tRNA ligase activity
SAD14_RS21240	COG0285	dihydrofolate synthase activity
SAD14_RS21250	COG0105	UTP biosynthetic process
SAD14_RS21255	COG1077	Cell shape determining protein MreB Mrl
SAD14_RS21275	COG0772	Belongs to the SEDS family
SAD14_RS21300	COG1530	ribonuclease E activity
SAD14_RS21305	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SAD14_RS21310	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SAD14_RS21315	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SAD14_RS21335	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SAD14_RS21345	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SAD14_RS21365	COG0501	Belongs to the peptidase M48B family
SAD14_RS21380	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SAD14_RS21390	COG0799	negative regulation of ribosome biogenesis
SAD14_RS21395	COG0588	phosphoglycerate mutase activity
SAD14_RS21420	COG0495	leucyl-tRNA aminoacylation
SAD14_RS21430	COG1307	EDD domain protein, DegV family
SAD14_RS21435	COG1555	photosystem II stabilization
SAD14_RS21450	COG2353	YceI-like domain
SAD14_RS21465	COG0268	Binds directly to 16S ribosomal RNA
SAD14_RS21470	COG0481	GTPase activity
SAD14_RS21505	COG0484	heat shock protein binding
SAD14_RS21520	COG0793	Belongs to the peptidase S41A family
SAD14_RS21520	COG4946	Tricorn protease homolog
SAD14_RS21525	COG0537	adenosine 5'-monophosphoramidase activity
SAD14_RS21530	COG1234	tRNA 3'-trailer cleavage
SAD14_RS21550	COG2515	1-aminocyclopropane-1-carboxylate deaminase
SAD14_RS21555	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SAD14_RS21580	COG1486	melibiose metabolic process
SAD14_RS21585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SAD14_RS21605	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SAD14_RS21615	COG2315	Protein conserved in bacteria
SAD14_RS21625	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SAD14_RS21640	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SAD14_RS21655	COG1381	Involved in DNA repair and RecF pathway recombination
SAD14_RS21660	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SAD14_RS21670	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SAD14_RS21675	COG1121	(ABC) transporter
SAD14_RS21685	COG0423	glycine-tRNA ligase activity
SAD14_RS21755	COG0189	ligase activity
SAD14_RS21765	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SAD14_RS21780	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SAD14_RS21785	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
SAD14_RS21795	COG3467	pyridoxamine 5'-phosphate
SAD14_RS21820	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
SAD14_RS21825	COG1846	Transcriptional regulator
SAD14_RS21825	COG1940	carbohydrate kinase activity
SAD14_RS21835	COG0574	Belongs to the PEP-utilizing enzyme family
SAD14_RS21835	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SAD14_RS21850	COG1324	tolerance protein
SAD14_RS21860	COG0829	nickel cation binding
SAD14_RS21865	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SAD14_RS21870	COG0830	nickel cation binding
SAD14_RS21875	COG0804	urea catabolic process
SAD14_RS21880	COG0832	Belongs to the urease beta subunit family
SAD14_RS21890	COG0738	Major facilitator superfamily
SAD14_RS21895	COG1028	Short-chain dehydrogenase reductase Sdr
SAD14_RS21910	COG2226	methyltransferase
SAD14_RS21950	COG1070	Carbohydrate kinase
SAD14_RS21970	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SAD14_RS21975	COG0358	DNA primase activity
SAD14_RS21985	COG3290	protein histidine kinase activity
SAD14_RS21990	COG4565	transcriptional regulatory protein
SAD14_RS21995	COG2851	Citrate transporter
SAD14_RS22005	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SAD14_RS22025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAD14_RS22050	COG1028	Short-chain dehydrogenase reductase Sdr
SAD14_RS22065	COG2890	protein-(glutamine-N5) methyltransferase activity
SAD14_RS22080	COG1077	Cell shape determining protein MreB Mrl
SAD14_RS22105	COG2130	NADP-dependent
SAD14_RS22110	COG1764	response to oxidative stress
SAD14_RS22140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SAD14_RS22145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SAD14_RS22150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SAD14_RS22165	COG1741	Belongs to the pirin family
SAD14_RS22180	COG0789	Transcriptional regulator
SAD14_RS22185	COG0667	Aldo Keto reductase
SAD14_RS22200	COG2197	response regulator
SAD14_RS22205	COG4585	Histidine kinase
SAD14_RS22225	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SAD14_RS22270	COG1358	cellular component organization or biogenesis
SAD14_RS22285	COG0586	Pfam SNARE associated Golgi protein
SAD14_RS22390	COG3845	ABC transporter
SAD14_RS22405	COG1657	PFAM Prenyltransferase squalene oxidase
SAD14_RS22410	COG0438	transferase activity, transferring glycosyl groups
SAD14_RS22440	COG0477	Major facilitator Superfamily
SAD14_RS22445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SAD14_RS22450	COG1960	acyl-CoA dehydrogenase activity
SAD14_RS22465	COG2197	response regulator
SAD14_RS22470	COG0346	lactoylglutathione lyase activity
SAD14_RS22475	COG4585	Histidine kinase
SAD14_RS22485	COG1131	(ABC) transporter
SAD14_RS22500	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SAD14_RS22520	COG0800	Aldolase
SAD14_RS22525	COG3022	response to hydroperoxide
SAD14_RS22565	COG1733	regulation of RNA biosynthetic process
SAD14_RS22585	COG2226	methyltransferase
SAD14_RS22590	COG0384	phenazine biosynthesis protein PhzF
SAD14_RS22610	COG0076	glutamate decarboxylase activity
SAD14_RS22620	COG2814	Major facilitator Superfamily
SAD14_RS22625	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SAD14_RS22635	COG1834	amidinotransferase
SAD14_RS22655	COG1120	ATPase activity
SAD14_RS22660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAD14_RS22665	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SAD14_RS22710	COG1994	Peptidase M50
SAD14_RS22715	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SAD14_RS22730	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SAD14_RS22730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SAD14_RS22735	COG2132	Multicopper oxidase
SAD14_RS22755	COG0174	glutamine synthetase
SAD14_RS22780	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SAD14_RS22795	COG0531	amino acid
SAD14_RS22800	COG1228	amidohydrolase
SAD14_RS22815	COG1609	Transcriptional regulator
SAD14_RS22820	COG2182	Extracellular solute-binding protein
SAD14_RS22825	COG1175	transmembrane transport
SAD14_RS22830	COG0395	ABC-type sugar transport system, permease component
SAD14_RS22835	COG0366	Alpha amylase catalytic
SAD14_RS22860	COG1309	transcriptional regulator
SAD14_RS22890	COG0745	RESPONSE REGULATOR receiver
SAD14_RS22920	COG1012	belongs to the aldehyde dehydrogenase family
SAD14_RS22985	COG2326	polyphosphate kinase activity
SAD14_RS22995	COG2376	Dihydroxyacetone kinase
SAD14_RS23005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SAD14_RS23045	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SAD14_RS23050	COG0321	lipoyl(octanoyl) transferase activity
SAD14_RS23060	COG0456	acetyltransferase
SAD14_RS23085	COG4221	oxidoreductase activity
SAD14_RS23100	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SAD14_RS23110	COG0508	dehydrogenase complex catalyzes the overall conversion of
SAD14_RS23115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SAD14_RS23120	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SAD14_RS23125	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SAD14_RS23135	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SAD14_RS23180	COG2197	response regulator
SAD14_RS23185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SAD14_RS23190	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SAD14_RS23215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SAD14_RS23220	COG1104	cysteine desulfurase activity
SAD14_RS23225	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SAD14_RS23230	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SAD14_RS23240	COG1376	ErfK ybiS ycfS ynhG family protein
SAD14_RS23250	COG1845	cytochrome c oxidase, subunit III
SAD14_RS23255	COG2010	Cytochrome c
SAD14_RS23260	COG0723	plastoquinol--plastocyanin reductase activity
SAD14_RS23265	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SAD14_RS23270	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SAD14_RS23275	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SAD14_RS23280	COG1929	Belongs to the glycerate kinase type-1 family
SAD14_RS23290	COG0745	RESPONSE REGULATOR receiver
SAD14_RS23295	COG5002	protein histidine kinase activity
SAD14_RS23310	COG0705	Rhomboid family
SAD14_RS23345	COG0438	transferase activity, transferring glycosyl groups
SAD14_RS23365	COG0003	Pfam Anion-transporting ATPase
SAD14_RS23375	COG1940	carbohydrate kinase activity
SAD14_RS23400	COG4585	Histidine kinase
SAD14_RS23405	COG2197	response regulator
SAD14_RS23410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SAD14_RS23420	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SAD14_RS23425	COG0243	molybdopterin cofactor binding
SAD14_RS23430	COG2193	ferroxidase activity
SAD14_RS23435	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SAD14_RS23440	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SAD14_RS23445	COG0515	serine threonine protein kinase
SAD14_RS23445	COG2815	serine threonine protein kinase
SAD14_RS23450	COG2022	thiamine diphosphate biosynthetic process
SAD14_RS23460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SAD14_RS23460	COG2022	thiamine diphosphate biosynthetic process
SAD14_RS23465	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SAD14_RS23475	COG0352	thiamine-phosphate diphosphorylase activity
SAD14_RS23495	COG1309	transcriptional regulator
SAD14_RS23505	COG1121	(ABC) transporter
SAD14_RS23510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SAD14_RS23530	COG0714	Associated with various cellular activities
SAD14_RS23540	COG0275	rRNA processing
SAD14_RS23555	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SAD14_RS23565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SAD14_RS23570	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SAD14_RS23580	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SAD14_RS23585	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SAD14_RS23590	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SAD14_RS23595	COG1496	oxidoreductase activity
SAD14_RS23605	COG1799	cell septum assembly
SAD14_RS23615	COG3599	regulation of cell shape
SAD14_RS23620	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SAD14_RS23630	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SAD14_RS23640	COG2153	protein acetylation
SAD14_RS23655	COG0515	serine threonine protein kinase
SAD14_RS23675	COG0587	DNA-directed DNA polymerase activity
SAD14_RS23685	COG1432	Conserved Protein
SAD14_RS23705	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SAD14_RS23725	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SAD14_RS23730	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SAD14_RS23735	COG0131	Imidazoleglycerol-phosphate dehydratase
SAD14_RS23745	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SAD14_RS23750	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SAD14_RS23760	COG0107	imidazoleglycerol-phosphate synthase activity
SAD14_RS23765	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SAD14_RS23775	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SAD14_RS23805	COG0134	indole-3-glycerol-phosphate synthase activity
SAD14_RS23810	COG0133	tryptophan synthase activity
SAD14_RS23815	COG0159	tryptophan synthase activity
SAD14_RS23825	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SAD14_RS23835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SAD14_RS23840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SAD14_RS23870	COG0070	glutamate synthase
SAD14_RS23870	COG0067	glutamate synthase
SAD14_RS23870	COG0069	glutamate synthase activity
SAD14_RS23885	COG1278	Cold shock
SAD14_RS23890	COG0513	Belongs to the DEAD box helicase family
SAD14_RS23900	COG0287	Prephenate dehydrogenase
SAD14_RS23900	COG1605	Chorismate mutase
SAD14_RS23930	COG3486	L-lysine 6-monooxygenase (NADPH) activity
SAD14_RS23935	COG0737	Belongs to the 5'-nucleotidase family
SAD14_RS23975	COG0559	Belongs to the binding-protein-dependent transport system permease family
SAD14_RS23985	COG2746	aminoglycoside 3-N-acetyltransferase activity
SAD14_RS23990	COG2050	protein possibly involved in aromatic compounds catabolism
SAD14_RS24010	COG1643	Atp-dependent helicase
SAD14_RS24015	COG2226	methyltransferase
SAD14_RS24035	COG0237	dephospho-CoA kinase activity
SAD14_RS24060	COG1288	antiporter activity
SAD14_RS24110	COG0477	Major facilitator Superfamily
SAD14_RS24120	COG0584	glycerophosphoryl diester phosphodiesterase
SAD14_RS24130	COG0556	nucleotide-excision repair
SAD14_RS24150	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SAD14_RS24155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SAD14_RS24165	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SAD14_RS24185	COG1660	Displays ATPase and GTPase activities
SAD14_RS24195	COG1481	regulation of sporulation
SAD14_RS24200	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SAD14_RS24205	COG0126	phosphoglycerate kinase activity
SAD14_RS24210	COG0149	triose-phosphate isomerase activity
SAD14_RS24215	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SAD14_RS24225	COG0166	Belongs to the GPI family
SAD14_RS24230	COG0363	glucosamine-6-phosphate deaminase activity
SAD14_RS24245	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SAD14_RS24250	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SAD14_RS24255	COG0109	protoheme IX farnesyltransferase activity
SAD14_RS24280	COG1131	(ABC) transporter
SAD14_RS24295	COG0719	Fe-S assembly protein
SAD14_RS24305	COG0396	ATPase activity
SAD14_RS24310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SAD14_RS24315	COG0822	iron-sulfur transferase activity
SAD14_RS24325	COG2171	N-acyltransferase activity
SAD14_RS24360	COG2197	response regulator
SAD14_RS24365	COG4585	Histidine kinase
SAD14_RS24395	COG1902	pentaerythritol trinitrate reductase activity
SAD14_RS24400	COG5285	phytanoyl-CoA dioxygenase
SAD14_RS24405	COG1917	Cupin 2, conserved barrel domain protein
SAD14_RS24415	COG0456	acetyltransferase
SAD14_RS24420	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SAD14_RS24450	COG1797	cobyrinic acid a,c-diamide synthase activity
SAD14_RS24465	COG1492	cobalamin metabolic process
SAD14_RS24485	COG0235	Class ii aldolase
SAD14_RS24505	COG0488	(ABC) transporter
SAD14_RS24560	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SAD14_RS24580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SAD14_RS24595	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SAD14_RS24600	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SAD14_RS24610	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
SAD14_RS24630	COG2261	transglycosylase associated protein
SAD14_RS24635	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SAD14_RS24645	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SAD14_RS24655	COG2186	Transcriptional regulator
SAD14_RS24660	COG2807	transmembrane transport
SAD14_RS24680	COG0560	Phosphoserine phosphatase
SAD14_RS24680	COG3830	Belongs to the UPF0237 family
SAD14_RS24685	COG1716	ATPase activity
SAD14_RS24685	COG1131	(ABC) transporter
SAD14_RS24685	COG0842	Transport permease protein
SAD14_RS24695	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SAD14_RS24710	COG2197	response regulator
SAD14_RS24725	COG1119	ATPase activity
SAD14_RS24745	COG1881	PFAM PEBP family protein
SAD14_RS24755	COG2094	Belongs to the DNA glycosylase MPG family
SAD14_RS24790	COG0647	UMP catabolic process
SAD14_RS24810	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SAD14_RS24815	COG0497	DNA recombination
SAD14_RS24830	COG0297	glycogen (starch) synthase activity
SAD14_RS24835	COG3896	Chloramphenicol phosphotransferase-like protein
SAD14_RS24845	COG3387	PFAM Glycoside hydrolase 15-related
SAD14_RS24850	COG0504	CTP synthase activity
SAD14_RS24855	COG0494	nUDIX hydrolase
SAD14_RS24865	COG0686	Belongs to the AlaDH PNT family
SAD14_RS24880	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SAD14_RS24885	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SAD14_RS24890	COG1187	pseudouridine synthase activity
SAD14_RS24900	COG1397	ADP-ribosylglycohydrolase
SAD14_RS24905	COG3541	Predicted nucleotidyltransferase
SAD14_RS24920	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SAD14_RS24930	COG1160	GTP binding
SAD14_RS24950	COG0438	transferase activity, transferring glycosyl groups
SAD14_RS24970	COG0671	phosphoesterase, PA-phosphatase related
SAD14_RS24980	COG0477	Major facilitator Superfamily
SAD14_RS24985	COG1799	cell septum assembly
SAD14_RS25000	COG0765	amino acid transport
SAD14_RS25010	COG0765	amino acid transport
SAD14_RS25020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SAD14_RS25025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAD14_RS25045	COG0330	HflC and HflK could
SAD14_RS25060	COG0587	DNA-directed DNA polymerase activity
SAD14_RS25065	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SAD14_RS25130	COG1216	Glycosyl transferase, family 2
SAD14_RS25155	COG2755	lipolytic protein G-D-S-L family
SAD14_RS25175	COG3973	AAA domain
SAD14_RS25180	COG2188	Transcriptional regulator
SAD14_RS25185	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
SAD14_RS25210	COG1309	transcriptional regulator
SAD14_RS25250	COG3876	Protein conserved in bacteria
SAD14_RS25260	COG0488	(ABC) transporter
SAD14_RS25275	COG0318	PFAM AMP-dependent synthetase and ligase
SAD14_RS25285	COG1960	acyl-CoA dehydrogenase activity
SAD14_RS25305	COG2149	membrane
SAD14_RS25310	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SAD14_RS25350	COG3265	gluconokinase activity
SAD14_RS25360	COG3012	SEC-C Motif Domain Protein
SAD14_RS25365	COG3189	MarR family transcriptional regulator
SAD14_RS25375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SAD14_RS25410	COG0667	Aldo Keto reductase
SAD14_RS25415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAD14_RS25425	COG0598	Magnesium transport protein CorA
SAD14_RS25445	COG0215	cysteine-tRNA ligase activity
SAD14_RS25460	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SAD14_RS25465	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SAD14_RS25480	COG1410	methionine synthase
SAD14_RS25480	COG0646	methionine synthase
SAD14_RS25490	COG0747	negative chemotaxis
SAD14_RS25495	COG2197	response regulator
SAD14_RS25505	COG0517	IMP dehydrogenase activity
SAD14_RS25505	COG1994	Peptidase M50
SAD14_RS25525	COG1222	aaa ATPase
SAD14_RS25530	COG4122	O-methyltransferase activity
SAD14_RS25540	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SAD14_RS25545	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SAD14_RS25560	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SAD14_RS25595	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SAD14_RS25600	COG0805	protein transport
SAD14_RS25615	COG2124	cytochrome p450
SAD14_RS25645	COG0564	pseudouridine synthase activity
SAD14_RS25655	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SAD14_RS25665	COG1595	DNA-templated transcription, initiation
SAD14_RS25675	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SAD14_RS25680	COG0517	IMP dehydrogenase activity
SAD14_RS25680	COG4175	Glycine betaine
SAD14_RS25705	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SAD14_RS25710	COG0531	amino acid
SAD14_RS25715	COG2186	Transcriptional regulator
SAD14_RS25720	COG0174	glutamine synthetase
SAD14_RS25725	COG1012	belongs to the aldehyde dehydrogenase family
SAD14_RS25760	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SAD14_RS25770	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SAD14_RS25775	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SAD14_RS25780	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SAD14_RS25785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SAD14_RS25795	COG5002	protein histidine kinase activity
SAD14_RS25800	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SAD14_RS25805	COG0072	phenylalanine-tRNA ligase activity
SAD14_RS25805	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SAD14_RS25835	COG0697	spore germination
SAD14_RS25840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SAD14_RS25860	COG0477	Major facilitator Superfamily
SAD14_RS25880	COG2838	Isocitrate dehydrogenase
SAD14_RS25895	COG1309	transcriptional regulator
SAD14_RS25910	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SAD14_RS25950	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SAD14_RS25955	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SAD14_RS25960	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SAD14_RS25965	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SAD14_RS25970	COG1438	arginine binding
SAD14_RS25975	COG4585	Histidine kinase
SAD14_RS25980	COG2197	response regulator
SAD14_RS25990	COG2409	Drug exporters of the RND superfamily
SAD14_RS25995	COG0385	Bile acid
SAD14_RS26005	COG0165	Argininosuccinate lyase
SAD14_RS26030	COG0477	Major facilitator Superfamily
SAD14_RS26035	COG0204	Acyl-transferase
SAD14_RS26035	COG0318	PFAM AMP-dependent synthetase and ligase
SAD14_RS26040	COG0584	glycerophosphoryl diester phosphodiesterase
SAD14_RS26065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SAD14_RS26070	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SAD14_RS26075	COG2011	ABC-type metal ion transport system permease component
SAD14_RS26080	COG1464	Belongs to the NlpA lipoprotein family
SAD14_RS26085	COG1464	Belongs to the NlpA lipoprotein family
SAD14_RS26100	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SAD14_RS26105	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SAD14_RS26105	COG1648	precorrin-2 dehydrogenase activity
SAD14_RS26170	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SAD14_RS26180	COG0456	acetyltransferase
SAD14_RS26240	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SAD14_RS26245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SAD14_RS26260	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SAD14_RS26265	COG1560	Kdo2-lipid A biosynthetic process
SAD14_RS26270	COG0438	transferase activity, transferring glycosyl groups
SAD14_RS26280	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SAD14_RS26285	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SAD14_RS26290	COG0217	transcriptional regulatory protein
SAD14_RS26295	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SAD14_RS26300	COG0632	four-way junction helicase activity
SAD14_RS26305	COG2255	four-way junction helicase activity
SAD14_RS26315	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SAD14_RS26320	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SAD14_RS26325	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SAD14_RS26330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SAD14_RS26340	COG1196	nuclear chromosome segregation
SAD14_RS26345	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SAD14_RS26355	COG0124	histidyl-tRNA synthetase
SAD14_RS26370	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SAD14_RS26385	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SAD14_RS26390	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SAD14_RS26395	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SAD14_RS26400	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SAD14_RS26405	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SAD14_RS26410	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SAD14_RS26415	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SAD14_RS26425	COG0006	proline dipeptidase activity
SAD14_RS26430	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SAD14_RS26435	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SAD14_RS26445	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SAD14_RS26450	COG0540	Belongs to the ATCase OTCase family
SAD14_RS26455	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SAD14_RS26465	COG0505	Belongs to the CarA family
SAD14_RS26470	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SAD14_RS26475	COG0167	dihydroorotate dehydrogenase activity
SAD14_RS26480	COG0284	orotidine-5'-phosphate decarboxylase activity
SAD14_RS26495	COG1758	RNA polymerase activity
SAD14_RS26505	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SAD14_RS26540	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SAD14_RS26555	COG2318	DinB family
SAD14_RS26560	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SAD14_RS26565	COG2390	Transcriptional regulator
SAD14_RS26605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SAD14_RS26625	COG0697	spore germination
SAD14_RS26630	COG2233	PERMEase
SAD14_RS26640	COG0738	Major facilitator superfamily
SAD14_RS26645	COG1940	carbohydrate kinase activity
SAD14_RS26645	COG1846	Transcriptional regulator
SAD14_RS26650	COG1090	epimerase
SAD14_RS26665	COG3201	nicotinamide mononucleotide transporter
SAD14_RS26670	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SAD14_RS26670	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SAD14_RS26675	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SAD14_RS26680	COG0140	phosphoribosyl-ATP diphosphatase activity
SAD14_RS26685	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SAD14_RS26715	COG1960	acyl-CoA dehydrogenase activity
SAD14_RS26735	COG0463	Glycosyl transferase, family 2
SAD14_RS26740	COG3030	protein affecting phage T7 exclusion by the F plasmid
SAD14_RS26750	COG2270	Major facilitator Superfamily
SAD14_RS26760	COG2364	Membrane
SAD14_RS26765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SAD14_RS26850	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SAD14_RS26870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SAD14_RS26880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SAD14_RS26910	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SAD14_RS26930	COG1716	ATPase activity
SAD14_RS26950	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SAD14_RS26960	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SAD14_RS26960	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SAD14_RS27000	COG0539	negative regulation of cytoplasmic translation
SAD14_RS27020	COG0697	spore germination
SAD14_RS27035	COG0697	spore germination
SAD14_RS27055	COG4251	negative regulation of phosphorylation
SAD14_RS27065	COG0154	amidase activity
SAD14_RS27105	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SAD14_RS27135	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SAD14_RS27155	COG1982	Orn Lys Arg decarboxylase major
SAD14_RS27165	COG1968	undecaprenyl-diphosphatase activity
SAD14_RS27185	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SAD14_RS27250	COG0110	maltose O-acetyltransferase activity
SAD14_RS27260	COG1832	CoA-binding protein
SAD14_RS27265	COG1739	Uncharacterized protein family UPF0029
SAD14_RS27285	COG1595	DNA-templated transcription, initiation
SAD14_RS27305	COG0420	3'-5' exonuclease activity
SAD14_RS27310	COG0419	ATPase involved in DNA repair
SAD14_RS27315	COG1522	sequence-specific DNA binding
SAD14_RS27325	COG1028	Short-chain dehydrogenase reductase Sdr
SAD14_RS27340	COG0626	cystathionine gamma-synthase activity
SAD14_RS27365	COG2188	Transcriptional regulator
SAD14_RS27370	COG1940	carbohydrate kinase activity
SAD14_RS27385	COG3663	DNA glycosylase
SAD14_RS27390	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SAD14_RS27410	COG0456	acetyltransferase
SAD14_RS27415	COG0488	(ABC) transporter
SAD14_RS27420	COG0488	(ABC) transporter
SAD14_RS27430	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SAD14_RS27435	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SAD14_RS27440	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SAD14_RS27465	COG0791	NLP P60 protein
SAD14_RS27470	COG0740	serine-type endopeptidase activity
SAD14_RS27480	COG0831	urea catabolic process
SAD14_RS27485	COG0832	Belongs to the urease beta subunit family
SAD14_RS27490	COG0804	urea catabolic process
SAD14_RS27500	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SAD14_RS27505	COG0829	nickel cation binding
SAD14_RS27510	COG4552	Acetyltransferase involved in intracellular survival and related
SAD14_RS27515	COG0204	Acyl-transferase
SAD14_RS27545	COG1132	(ABC) transporter
SAD14_RS27560	COG2175	clavaminate synthase activity
SAD14_RS27570	COG0435	Glutathione S-transferase
SAD14_RS27575	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SAD14_RS27575	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SAD14_RS27585	COG2770	Histidine kinase
SAD14_RS27585	COG2208	phosphoserine phosphatase activity
SAD14_RS27600	COG0205	6-phosphofructokinase activity
SAD14_RS27605	COG3442	glutamine amidotransferase
SAD14_RS27615	COG0242	peptide deformylase activity
SAD14_RS27625	COG1960	acyl-CoA dehydrogenase activity
SAD14_RS27645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SAD14_RS27670	COG1175	transmembrane transport
SAD14_RS27675	COG0395	ABC-type sugar transport system, permease component
SAD14_RS27680	COG2723	6-phospho-beta-galactosidase activity
SAD14_RS27685	COG0501	Belongs to the peptidase M48B family
SAD14_RS27730	COG4251	negative regulation of phosphorylation
SAD14_RS27735	COG0784	Response regulator, receiver
SAD14_RS27755	COG0656	L-ascorbic acid biosynthetic process
SAD14_RS27765	COG1595	DNA-templated transcription, initiation
SAD14_RS27775	COG1132	(ABC) transporter
SAD14_RS27790	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SAD14_RS27825	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SAD14_RS27830	COG3279	Response regulator of the LytR AlgR family
SAD14_RS27840	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SAD14_RS27845	COG3275	phosphorelay sensor kinase activity
SAD14_RS27910	COG0583	DNA-binding transcription factor activity
SAD14_RS27920	COG1053	succinate dehydrogenase
SAD14_RS27925	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SAD14_RS27930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAD14_RS27940	COG3360	Dodecin
SAD14_RS27945	COG2182	Extracellular solute-binding protein
SAD14_RS27950	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SAD14_RS27955	COG0121	glutamine amidotransferase
SAD14_RS27960	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SAD14_RS27980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SAD14_RS27985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SAD14_RS28015	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SAD14_RS28015	COG1796	DNA polymerase
SAD14_RS28035	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SAD14_RS28045	COG0254	rRNA binding
SAD14_RS28050	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SAD14_RS28055	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SAD14_RS28060	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SAD14_RS28090	COG0477	Major facilitator Superfamily
SAD14_RS28120	COG3119	arylsulfatase activity
SAD14_RS28140	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SAD14_RS28145	COG4948	Mandelate Racemase Muconate Lactonizing
SAD14_RS28215	COG0464	growth
SAD14_RS28235	COG3655	Transcriptional regulator
SAD14_RS28255	COG0803	Belongs to the bacterial solute-binding protein 9 family
SAD14_RS28265	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SAD14_RS28270	COG1121	(ABC) transporter
SAD14_RS28275	COG0590	tRNA wobble adenosine to inosine editing
SAD14_RS28280	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SAD14_RS28310	COG2201	protein-glutamate methylesterase activity
SAD14_RS28315	COG0300	oxidoreductase activity
SAD14_RS28325	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SAD14_RS28360	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SAD14_RS28365	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SAD14_RS28370	COG1984	allophanate hydrolase subunit 2
SAD14_RS28410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAD14_RS28415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAD14_RS28420	COG1120	ATPase activity
SAD14_RS28450	COG1132	(ABC) transporter
SAD14_RS28455	COG1132	(ABC) transporter
SAD14_RS28460	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SAD14_RS28470	COG0110	maltose O-acetyltransferase activity
SAD14_RS28485	COG0242	peptide deformylase activity
SAD14_RS28505	COG1349	DNA-binding transcription factor activity
SAD14_RS28520	COG3395	kinase activity
SAD14_RS28525	COG0235	Class ii aldolase
SAD14_RS28555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SAD14_RS28565	COG4608	Belongs to the ABC transporter superfamily
SAD14_RS28570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAD14_RS28585	COG1174	glycine betaine transport
SAD14_RS28590	COG1174	glycine betaine transport
SAD14_RS28600	COG0517	IMP dehydrogenase activity
SAD14_RS28600	COG1125	glycine betaine transport
SAD14_RS28625	COG1960	acyl-CoA dehydrogenase activity
SAD14_RS28630	COG1960	acyl-CoA dehydrogenase activity
SAD14_RS28640	COG0601	transmembrane transport
SAD14_RS28645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SAD14_RS28650	COG0444	Belongs to the ABC transporter superfamily
SAD14_RS28655	COG1124	(ABC) transporter
SAD14_RS28665	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
SAD14_RS28670	COG2318	DinB family
SAD14_RS28695	COG0277	FAD linked oxidase domain protein
SAD14_RS28700	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SAD14_RS28715	COG2271	Major facilitator Superfamily
SAD14_RS28765	COG1028	Short-chain dehydrogenase reductase Sdr
SAD14_RS28790	COG1404	Belongs to the peptidase S8 family
SAD14_RS28820	COG4335	DNA alkylation repair
SAD14_RS28845	COG0477	Major facilitator Superfamily
SAD14_RS28875	COG3246	L-lysine catabolic process to acetate
SAD14_RS28880	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAD14_RS28925	COG1278	Cold shock