locus-tag	class	description
IT782_RS00005	COG1472	Belongs to the glycosyl hydrolase 3 family
IT782_RS00010	COG1874	Beta-galactosidase
IT782_RS00015	COG1609	Transcriptional regulator
IT782_RS00020	COG0395	ABC-type sugar transport system, permease component
IT782_RS00025	COG1175	transmembrane transport
IT782_RS00045	COG1028	Short-chain dehydrogenase reductase Sdr
IT782_RS00050	COG0477	Major facilitator Superfamily
IT782_RS00075	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IT782_RS00080	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IT782_RS00085	COG2080	2 iron, 2 sulfur cluster binding
IT782_RS00095	COG2197	response regulator
IT782_RS00100	COG4585	Histidine kinase
IT782_RS00105	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
IT782_RS00125	COG0477	Major facilitator Superfamily
IT782_RS00180	COG0446	pyridine nucleotide-disulphide oxidoreductase
IT782_RS00180	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IT782_RS00230	COG4608	Belongs to the ABC transporter superfamily
IT782_RS00235	COG0444	Belongs to the ABC transporter superfamily
IT782_RS00245	COG0601	transmembrane transport
IT782_RS00250	COG0747	negative chemotaxis
IT782_RS00260	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IT782_RS00290	COG1793	dna ligase
IT782_RS00325	COG0277	FAD linked oxidase domain protein
IT782_RS00370	COG0318	PFAM AMP-dependent synthetase and ligase
IT782_RS00375	COG0589	response to stress
IT782_RS00380	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IT782_RS00385	COG2813	Specifically methylates the guanine in position
IT782_RS00395	COG2356	endonuclease I
IT782_RS00425	COG2084	Dehydrogenase
IT782_RS00460	COG1007	ATP synthesis coupled electron transport
IT782_RS00465	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IT782_RS00470	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IT782_RS00475	COG0713	ATP synthesis coupled electron transport
IT782_RS00485	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IT782_RS00495	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IT782_RS00505	COG4733	cellulase activity
IT782_RS00505	COG5297	Belongs to the glycosyl hydrolase family 6
IT782_RS00515	COG1902	pentaerythritol trinitrate reductase activity
IT782_RS00515	COG0446	pyridine nucleotide-disulphide oxidoreductase
IT782_RS00525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IT782_RS00560	COG0475	glutathione-regulated potassium exporter activity
IT782_RS00580	COG2197	response regulator
IT782_RS00590	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IT782_RS00605	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IT782_RS00615	COG0640	Transcriptional regulator
IT782_RS00630	COG0531	amino acid
IT782_RS00650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IT782_RS00655	COG2192	nodulation
IT782_RS00660	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IT782_RS00665	COG0859	PFAM glycosyl transferase family 9
IT782_RS00675	COG0297	glycogen (starch) synthase activity
IT782_RS00680	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IT782_RS00685	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IT782_RS00685	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IT782_RS00690	COG0859	PFAM glycosyl transferase family 9
IT782_RS00715	COG1028	Short-chain dehydrogenase reductase Sdr
IT782_RS00720	COG1482	cell wall glycoprotein biosynthetic process
IT782_RS00725	COG0477	Major facilitator Superfamily
IT782_RS00740	COG0328	RNA-DNA hybrid ribonuclease activity
IT782_RS00750	COG0431	NADPH-dependent FMN reductase
IT782_RS00780	COG1595	DNA-templated transcription, initiation
IT782_RS00805	COG0667	Aldo Keto reductase
IT782_RS00845	COG1131	(ABC) transporter
IT782_RS00865	COG0326	Molecular chaperone. Has ATPase activity
IT782_RS00890	COG0346	lactoylglutathione lyase activity
IT782_RS00895	COG0640	Transcriptional regulator
IT782_RS00910	COG1120	ATPase activity
IT782_RS00925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IT782_RS00945	COG1250	3-hydroxyacyl-CoA dehydrogenase
IT782_RS00950	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IT782_RS00955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IT782_RS00970	COG1349	DNA-binding transcription factor activity
IT782_RS00980	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IT782_RS00980	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IT782_RS00980	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IT782_RS00985	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IT782_RS00985	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IT782_RS01010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IT782_RS01030	COG2226	methyltransferase
IT782_RS01075	COG1028	Short-chain dehydrogenase reductase Sdr
IT782_RS01090	COG0513	Belongs to the DEAD box helicase family
IT782_RS01100	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IT782_RS01115	COG0633	Ferredoxin
IT782_RS01115	COG3217	Mosc domain protein beta barrel domain protein
IT782_RS01135	COG1349	DNA-binding transcription factor activity
IT782_RS01155	COG1940	carbohydrate kinase activity
IT782_RS01165	COG2223	nitrite transmembrane transporter activity
IT782_RS01180	COG2197	response regulator
IT782_RS01185	COG0445	tRNA wobble uridine modification
IT782_RS01195	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IT782_RS01210	COG1609	Transcriptional regulator
IT782_RS01225	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IT782_RS01270	COG0584	glycerophosphoryl diester phosphodiesterase
IT782_RS01285	COG1846	Transcriptional regulator
IT782_RS01305	COG0671	phosphoesterase, PA-phosphatase related
IT782_RS01330	COG2233	PERMEase
IT782_RS01335	COG0640	Transcriptional regulator
IT782_RS01365	COG0586	Pfam SNARE associated Golgi protein
IT782_RS01370	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IT782_RS01385	COG2706	6-phosphogluconolactonase activity
IT782_RS01400	COG0071	Belongs to the small heat shock protein (HSP20) family
IT782_RS01410	COG0243	molybdopterin cofactor binding
IT782_RS01445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IT782_RS01470	COG2814	Major facilitator Superfamily
IT782_RS01495	COG1309	transcriptional regulator
IT782_RS01510	COG1472	Belongs to the glycosyl hydrolase 3 family
IT782_RS01515	COG0395	ABC-type sugar transport system, permease component
IT782_RS01520	COG1175	transmembrane transport
IT782_RS01530	COG1609	Transcriptional regulator
IT782_RS01555	COG0432	Pfam Uncharacterised protein family UPF0047
IT782_RS01560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IT782_RS01565	COG1116	anion transmembrane transporter activity
IT782_RS01575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IT782_RS01585	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IT782_RS01590	COG1132	(ABC) transporter
IT782_RS01610	COG1132	(ABC) transporter
IT782_RS01615	COG1132	(ABC) transporter
IT782_RS01630	COG1946	Acyl-CoA thioesterase
IT782_RS01645	COG2018	Roadblock/LC7 domain
IT782_RS01690	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IT782_RS01715	COG1070	Carbohydrate kinase
IT782_RS01730	COG2130	NADP-dependent
IT782_RS01830	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IT782_RS01835	COG1250	3-hydroxyacyl-CoA dehydrogenase
IT782_RS01840	COG1960	acyl-CoA dehydrogenase activity
IT782_RS01845	COG2391	methyltransferase activity
IT782_RS01890	COG1396	sequence-specific DNA binding
IT782_RS01895	COG0740	serine-type endopeptidase activity
IT782_RS01900	COG0740	serine-type endopeptidase activity
IT782_RS01950	COG3959	Transketolase, thiamine diphosphate binding domain
IT782_RS01955	COG3958	Transketolase
IT782_RS02025	COG2755	lipolytic protein G-D-S-L family
IT782_RS02030	COG2365	Tyrosine phosphatase family
IT782_RS02060	COG1657	PFAM Prenyltransferase squalene oxidase
IT782_RS02070	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IT782_RS02080	COG1562	ergosterol biosynthetic process
IT782_RS02085	COG1388	LysM domain
IT782_RS02085	COG1134	teichoic acid transport
IT782_RS02110	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IT782_RS02125	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IT782_RS02135	COG1162	GTPase activity
IT782_RS02150	COG1024	Enoyl-CoA hydratase
IT782_RS02175	COG1802	Transcriptional regulator
IT782_RS02180	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IT782_RS02185	COG0402	S-adenosylhomocysteine deaminase activity
IT782_RS02205	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IT782_RS02210	COG0789	Transcriptional regulator
IT782_RS02215	COG1250	3-hydroxyacyl-CoA dehydrogenase
IT782_RS02215	COG1024	Enoyl-CoA hydratase
IT782_RS02220	COG0183	Belongs to the thiolase family
IT782_RS02225	COG1960	acyl-CoA dehydrogenase activity
IT782_RS02230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IT782_RS02235	COG1683	Conserved Protein
IT782_RS02240	COG1515	deoxyribonuclease V activity
IT782_RS02260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IT782_RS02270	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IT782_RS02270	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IT782_RS02280	COG0488	(ABC) transporter
IT782_RS02300	COG2197	response regulator
IT782_RS02315	COG0438	transferase activity, transferring glycosyl groups
IT782_RS02350	COG0254	rRNA binding
IT782_RS02365	COG1024	Enoyl-CoA hydratase
IT782_RS02400	COG0789	Transcriptional regulator
IT782_RS02425	COG2319	Wd-40 repeat
IT782_RS02425	COG4249	Peptidase C14 caspase catalytic subunit p20
IT782_RS02460	COG1846	Transcriptional regulator
IT782_RS02495	COG1028	Short-chain dehydrogenase reductase Sdr
IT782_RS02520	COG1012	belongs to the aldehyde dehydrogenase family
IT782_RS02530	COG2080	2 iron, 2 sulfur cluster binding
IT782_RS02540	COG2814	Major facilitator Superfamily
IT782_RS02545	COG2259	Doxx family
IT782_RS02555	COG1869	D-ribose catabolic process
IT782_RS02560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IT782_RS02570	COG1129	ABC transporter
IT782_RS02575	COG1609	Transcriptional regulator
IT782_RS02595	COG1295	ribonuclease BN
IT782_RS02660	COG0673	inositol 2-dehydrogenase activity
IT782_RS02670	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT782_RS02675	COG1129	ABC transporter
IT782_RS02680	COG1940	carbohydrate kinase activity
IT782_RS02685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IT782_RS02700	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IT782_RS02710	COG0583	DNA-binding transcription factor activity
IT782_RS02715	COG1115	amino acid carrier protein
IT782_RS02740	COG2154	pterin-4-alpha-carbinolamine dehydratase
IT782_RS02770	COG1140	nitrate reductase beta subunit
IT782_RS02785	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
IT782_RS02835	COG0693	protein deglycase activity
IT782_RS02845	COG1597	lipid kinase activity
IT782_RS02850	COG4106	trans-aconitate 2-methyltransferase activity
IT782_RS02865	COG3226	Transcriptional regulator
IT782_RS02885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IT782_RS02900	COG1619	proteins homologs of microcin C7 resistance protein MccF
IT782_RS02910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IT782_RS02955	COG0596	Alpha beta hydrolase
IT782_RS02975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT782_RS02980	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT782_RS02985	COG1120	ATPase activity
IT782_RS02990	COG1250	3-hydroxyacyl-CoA dehydrogenase
IT782_RS03000	COG0604	alcohol dehydrogenase
IT782_RS03005	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IT782_RS03005	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IT782_RS03010	COG2301	Belongs to the HpcH HpaI aldolase family
IT782_RS03025	COG0688	phosphatidylethanolamine metabolic process
IT782_RS03035	COG1929	Belongs to the glycerate kinase type-1 family
IT782_RS03040	COG0488	(ABC) transporter
IT782_RS03050	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IT782_RS03070	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
IT782_RS03095	COG0159	tryptophan synthase activity
IT782_RS03110	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IT782_RS03125	COG0483	inositol monophosphate 1-phosphatase activity
IT782_RS03135	COG0095	Lipoate-protein ligase
IT782_RS03155	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IT782_RS03180	COG0405	Gamma-glutamyltransferase
IT782_RS03210	COG0765	amino acid transport
IT782_RS03215	COG0765	amino acid transport
IT782_RS03220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IT782_RS03225	COG1126	abc transporter atp-binding protein
IT782_RS03255	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IT782_RS03265	COG1960	acyl-CoA dehydrogenase activity
IT782_RS03285	COG5183	chlorophyll binding
IT782_RS03285	COG2133	pyrroloquinoline quinone binding
IT782_RS03290	COG1132	(ABC) transporter
IT782_RS03295	COG1132	(ABC) transporter
IT782_RS03330	COG2197	response regulator
IT782_RS03340	COG0464	growth
IT782_RS03430	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IT782_RS03440	COG1940	carbohydrate kinase activity
IT782_RS03450	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT782_RS03460	COG2188	Transcriptional regulator
IT782_RS03465	COG0673	inositol 2-dehydrogenase activity
IT782_RS03485	COG2197	response regulator
IT782_RS03490	COG4585	Histidine kinase
IT782_RS03505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IT782_RS03510	COG1414	Transcriptional regulator
IT782_RS03525	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IT782_RS03530	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IT782_RS03535	COG2080	2 iron, 2 sulfur cluster binding
IT782_RS03540	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IT782_RS03555	COG4941	Belongs to the sigma-70 factor family
IT782_RS03560	COG3795	YCII-related domain
IT782_RS03565	COG0723	plastoquinol--plastocyanin reductase activity
IT782_RS03565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IT782_RS03570	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IT782_RS03575	COG1621	beta-fructofuranosidase activity
IT782_RS03580	COG1609	Transcriptional regulator
IT782_RS03645	COG2233	PERMEase
IT782_RS03660	COG2351	hydroxyisourate hydrolase activity
IT782_RS03680	COG3622	Belongs to the hyi family
IT782_RS03685	COG2084	Dehydrogenase
IT782_RS03690	COG0753	catalase activity
IT782_RS03715	COG3960	tartronate-semialdehyde synthase activity
IT782_RS03725	COG0318	PFAM AMP-dependent synthetase and ligase
IT782_RS03730	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IT782_RS03735	COG2197	response regulator
IT782_RS03745	COG1309	transcriptional regulator
IT782_RS03780	COG2252	PERMEase
IT782_RS03785	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IT782_RS03800	COG3835	regulator
IT782_RS03805	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
IT782_RS03815	COG1802	Transcriptional regulator
IT782_RS03840	COG0028	Belongs to the TPP enzyme family
IT782_RS03860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IT782_RS03865	COG1162	GTPase activity
IT782_RS03870	COG2124	cytochrome p450
IT782_RS03875	COG0028	Belongs to the TPP enzyme family
IT782_RS03890	COG2365	Tyrosine phosphatase family
IT782_RS03910	COG0583	DNA-binding transcription factor activity
IT782_RS03930	COG1595	DNA-templated transcription, initiation
IT782_RS03955	COG1846	Transcriptional regulator
IT782_RS03960	COG2409	Drug exporters of the RND superfamily
IT782_RS03970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT782_RS03975	COG1120	ATPase activity
IT782_RS03990	COG1309	transcriptional regulator
IT782_RS04005	COG2255	four-way junction helicase activity
IT782_RS04030	COG2040	homocysteine
IT782_RS04050	COG1960	acyl-CoA dehydrogenase activity
IT782_RS04055	COG0604	alcohol dehydrogenase
IT782_RS04080	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IT782_RS04090	COG0175	sulfate reduction
IT782_RS04095	COG0529	Catalyzes the synthesis of activated sulfate
IT782_RS04120	COG1116	anion transmembrane transporter activity
IT782_RS04125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IT782_RS04140	COG0386	Belongs to the glutathione peroxidase family
IT782_RS04145	COG1064	alcohol dehydrogenase
IT782_RS04150	COG1309	transcriptional regulator
IT782_RS04160	COG3547	Transposase (IS116 IS110 IS902 family)
IT782_RS04190	COG2176	DNA-directed DNA polymerase activity
IT782_RS04190	COG5002	protein histidine kinase activity
IT782_RS04255	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IT782_RS04260	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IT782_RS04280	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IT782_RS04300	COG0726	polysaccharide deacetylase
IT782_RS04310	COG3220	belongs to the UPF0276 family
IT782_RS04320	COG3253	May function as heme-dependent peroxidase
IT782_RS04325	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IT782_RS04335	COG0446	pyridine nucleotide-disulphide oxidoreductase
IT782_RS04340	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IT782_RS04360	COG0183	Belongs to the thiolase family
IT782_RS04365	COG1250	3-hydroxyacyl-CoA dehydrogenase
IT782_RS04365	COG1024	Enoyl-CoA hydratase
IT782_RS04385	COG0531	amino acid
IT782_RS04390	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IT782_RS04395	COG4214	carbohydrate transport
IT782_RS04405	COG4213	ABC transporter substrate-binding protein
IT782_RS04415	COG0395	ABC-type sugar transport system, permease component
IT782_RS04420	COG1175	transmembrane transport
IT782_RS04425	COG1653	transport
IT782_RS04430	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IT782_RS04455	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IT782_RS04495	COG2235	arginine
IT782_RS04500	COG1320	monovalent cation:proton antiporter activity
IT782_RS04515	COG0651	ATP synthesis coupled electron transport
IT782_RS04520	COG1006	Multisubunit Na H antiporter MnhC subunit
IT782_RS04525	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IT782_RS04525	COG2111	Na H antiporter
IT782_RS04535	COG2124	cytochrome p450
IT782_RS04565	COG0531	amino acid
IT782_RS04570	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IT782_RS04575	COG2235	arginine
IT782_RS04585	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IT782_RS04620	COG1799	cell septum assembly
IT782_RS04630	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
IT782_RS04645	COG1556	Lactate utilization protein
IT782_RS04650	COG1139	Iron-sulfur cluster binding protein
IT782_RS04655	COG0247	lactate metabolic process
IT782_RS04660	COG1620	l-lactate permease
IT782_RS04670	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IT782_RS04710	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IT782_RS04720	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IT782_RS04730	COG0477	Major facilitator Superfamily
IT782_RS04735	COG1120	ATPase activity
IT782_RS04740	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT782_RS04745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT782_RS04755	COG1733	regulation of RNA biosynthetic process
IT782_RS04780	COG1309	transcriptional regulator
IT782_RS04795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IT782_RS04810	COG2936	dipeptidyl-peptidase activity
IT782_RS04825	COG1028	Short-chain dehydrogenase reductase Sdr
IT782_RS04830	COG3540	Alkaline phosphatase
IT782_RS04840	COG2050	protein possibly involved in aromatic compounds catabolism
IT782_RS04855	COG0789	Transcriptional regulator
IT782_RS04865	COG0640	Transcriptional regulator
IT782_RS04885	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IT782_RS04950	COG0438	transferase activity, transferring glycosyl groups
IT782_RS04955	COG3226	Transcriptional regulator
IT782_RS04960	COG0738	Major facilitator superfamily
IT782_RS04975	COG4213	ABC transporter substrate-binding protein
IT782_RS04980	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT782_RS04985	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT782_RS04990	COG1129	ABC transporter
IT782_RS04995	COG1940	carbohydrate kinase activity
IT782_RS04995	COG1846	Transcriptional regulator
IT782_RS05000	COG0252	asparaginase activity
IT782_RS05035	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
IT782_RS05045	COG0473	3-isopropylmalate dehydrogenase activity
IT782_RS05060	COG0656	L-ascorbic acid biosynthetic process
IT782_RS05095	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IT782_RS05120	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IT782_RS05130	COG1127	ABC transporter
IT782_RS05210	COG0395	ABC-type sugar transport system, permease component
IT782_RS05215	COG1063	alcohol dehydrogenase
IT782_RS05225	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IT782_RS05225	COG0515	serine threonine protein kinase
IT782_RS05260	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IT782_RS05265	COG0531	amino acid
IT782_RS05275	COG0569	domain protein
IT782_RS05305	COG1136	(ABC) transporter
IT782_RS05325	COG0756	dUTP diphosphatase activity
IT782_RS05350	COG2205	protein histidine kinase activity
IT782_RS05355	COG0745	RESPONSE REGULATOR receiver
IT782_RS05365	COG0483	inositol monophosphate 1-phosphatase activity
IT782_RS05370	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IT782_RS05420	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IT782_RS05430	COG1802	Transcriptional regulator
IT782_RS05445	COG0612	Peptidase, M16
IT782_RS05450	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IT782_RS05455	COG0523	cobalamin synthesis protein
IT782_RS05460	COG0366	Alpha amylase catalytic
IT782_RS05465	COG0395	ABC-type sugar transport system, permease component
IT782_RS05470	COG1175	transmembrane transport
IT782_RS05490	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IT782_RS05525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IT782_RS05530	COG1802	Transcriptional regulator
IT782_RS05570	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IT782_RS05585	COG0588	phosphoglycerate mutase activity
IT782_RS05610	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IT782_RS05615	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IT782_RS05620	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IT782_RS05660	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IT782_RS05670	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IT782_RS05675	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IT782_RS05685	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IT782_RS05705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IT782_RS05710	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IT782_RS05715	COG2205	protein histidine kinase activity
IT782_RS05725	COG1126	abc transporter atp-binding protein
IT782_RS05730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IT782_RS05735	COG0765	amino acid transport
IT782_RS05740	COG0765	amino acid transport
IT782_RS05745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IT782_RS05755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IT782_RS05760	COG2137	regulation of response to DNA damage stimulus
IT782_RS05765	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IT782_RS05800	COG0628	permease
IT782_RS05825	COG1201	RNA secondary structure unwinding
IT782_RS05830	COG0596	Alpha beta hydrolase
IT782_RS05850	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IT782_RS05860	COG0783	Belongs to the Dps family
IT782_RS05865	COG1396	sequence-specific DNA binding
IT782_RS05870	COG1546	Belongs to the CinA family
IT782_RS05870	COG1058	Belongs to the CinA family
IT782_RS05880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IT782_RS05890	COG1674	ftsk spoiiie
IT782_RS05900	COG3437	response regulator, receiver
IT782_RS05900	COG3850	Histidine kinase
IT782_RS05900	COG4999	Histidine kinase
IT782_RS05900	COG2205	protein histidine kinase activity
IT782_RS05905	COG2208	phosphoserine phosphatase activity
IT782_RS05905	COG2770	Histidine kinase
IT782_RS05935	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IT782_RS05940	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IT782_RS05945	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
IT782_RS05965	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IT782_RS05970	COG0612	Peptidase, M16
IT782_RS05975	COG1185	polyribonucleotide nucleotidyltransferase activity
IT782_RS05980	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IT782_RS05990	COG0455	bacterial-type flagellum organization
IT782_RS05995	COG0747	negative chemotaxis
IT782_RS06000	COG0601	transmembrane transport
IT782_RS06005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT782_RS06015	COG4608	Belongs to the ABC transporter superfamily
IT782_RS06020	COG1357	PFAM Pentapeptide repeats (8 copies)
IT782_RS06035	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IT782_RS06040	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IT782_RS06050	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IT782_RS06065	COG0779	Required for maturation of 30S ribosomal subunits
IT782_RS06085	COG0442	prolyl-tRNA aminoacylation
IT782_RS06105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT782_RS06110	COG0601	transmembrane transport
IT782_RS06130	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IT782_RS06135	COG0750	zinc metalloprotease
IT782_RS06140	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IT782_RS06145	COG1940	carbohydrate kinase activity
IT782_RS06150	COG1012	belongs to the aldehyde dehydrogenase family
IT782_RS06155	COG2508	Transcriptional regulator
IT782_RS06155	COG2508	Transcriptional regulator
IT782_RS06185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IT782_RS06190	COG1177	transmembrane transport
IT782_RS06200	COG3842	ATPase activity
IT782_RS06210	COG1012	belongs to the aldehyde dehydrogenase family
IT782_RS06225	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IT782_RS06245	COG1012	belongs to the aldehyde dehydrogenase family
IT782_RS06255	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IT782_RS06265	COG1136	(ABC) transporter
IT782_RS06285	COG3842	ATPase activity
IT782_RS06290	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IT782_RS06300	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IT782_RS06305	COG0575	Belongs to the CDS family
IT782_RS06310	COG0233	cytoplasmic translational termination
IT782_RS06315	COG0528	UMP kinase activity
IT782_RS06320	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IT782_RS06325	COG0052	Belongs to the universal ribosomal protein uS2 family
IT782_RS06340	COG1191	sigma factor activity
IT782_RS06355	COG0792	nuclease activity
IT782_RS06370	COG0681	Belongs to the peptidase S26 family
IT782_RS06375	COG0681	Belongs to the peptidase S26 family
IT782_RS06390	COG0335	large ribosomal subunit rRNA binding
IT782_RS06395	COG0336	Belongs to the RNA methyltransferase TrmD family
IT782_RS06400	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IT782_RS06405	COG1837	Belongs to the UPF0109 family
IT782_RS06410	COG0228	four-way junction DNA binding
IT782_RS06425	COG2801	Transposase and inactivated derivatives
IT782_RS06425	COG3415	Transposase
IT782_RS06430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IT782_RS06440	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IT782_RS06470	COG0477	Major facilitator Superfamily
IT782_RS06475	COG1196	nuclear chromosome segregation
IT782_RS06485	COG1254	Belongs to the acylphosphatase family
IT782_RS06490	COG2340	Cysteine-rich secretory protein family
IT782_RS06495	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IT782_RS06500	COG0571	ribonuclease III activity
IT782_RS06505	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IT782_RS06520	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IT782_RS06525	COG0742	ribosomal rna small subunit methyltransferase
IT782_RS06540	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IT782_RS06545	COG0351	phosphomethylpyrimidine kinase
IT782_RS06565	COG1181	Belongs to the D-alanine--D-alanine ligase family
IT782_RS06570	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IT782_RS06580	COG1920	GTP binding
IT782_RS06590	COG0776	regulation of translation
IT782_RS06600	COG0066	3-isopropylmalate dehydratase activity
IT782_RS06605	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IT782_RS06610	COG1414	Transcriptional regulator
IT782_RS06655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IT782_RS06660	COG0179	Fumarylacetoacetate (FAA) hydrolase
IT782_RS06675	COG2018	Roadblock/LC7 domain
IT782_RS06695	COG2018	Roadblock/LC7 domain
IT782_RS06715	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IT782_RS06725	COG2353	YceI-like domain
IT782_RS06770	COG0789	Transcriptional regulator
IT782_RS06810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IT782_RS06815	COG2957	Belongs to the agmatine deiminase family
IT782_RS06825	COG0832	Belongs to the urease beta subunit family
IT782_RS06825	COG0831	urea catabolic process
IT782_RS06830	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IT782_RS06835	COG0473	3-isopropylmalate dehydrogenase activity
IT782_RS06850	COG0575	Belongs to the CDS family
IT782_RS06865	COG1012	belongs to the aldehyde dehydrogenase family
IT782_RS06870	COG0506	proline dehydrogenase activity
IT782_RS06875	COG3835	regulator
IT782_RS06895	COG2890	protein-(glutamine-N5) methyltransferase activity
IT782_RS06905	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IT782_RS06910	COG0440	acetolactate synthase activity
IT782_RS06930	COG0667	Aldo Keto reductase
IT782_RS06935	COG2133	pyrroloquinoline quinone binding
IT782_RS06945	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IT782_RS06945	COG1672	PFAM Archaeal ATPase
IT782_RS06965	COG2409	Drug exporters of the RND superfamily
IT782_RS06970	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IT782_RS06980	COG0154	amidase activity
IT782_RS06985	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IT782_RS06995	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IT782_RS07005	COG4221	oxidoreductase activity
IT782_RS07025	COG0482	sulfurtransferase activity
IT782_RS07050	COG2860	membrane
IT782_RS07055	COG4608	Belongs to the ABC transporter superfamily
IT782_RS07060	COG0444	Belongs to the ABC transporter superfamily
IT782_RS07065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT782_RS07070	COG0601	transmembrane transport
IT782_RS07075	COG4166	transmembrane transport
IT782_RS07095	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IT782_RS07100	COG0509	glycine decarboxylation via glycine cleavage system
IT782_RS07105	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IT782_RS07110	COG1760	l-serine dehydratase
IT782_RS07115	COG3547	Transposase (IS116 IS110 IS902 family)
IT782_RS07145	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IT782_RS07150	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IT782_RS07155	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
IT782_RS07170	COG0477	Major facilitator Superfamily
IT782_RS07185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IT782_RS07210	COG2085	NADP oxidoreductase coenzyme F420-dependent
IT782_RS07260	COG1131	(ABC) transporter
IT782_RS07265	COG1132	(ABC) transporter
IT782_RS07270	COG1132	(ABC) transporter
IT782_RS07290	COG0366	Alpha amylase catalytic
IT782_RS07295	COG0366	Alpha amylase catalytic
IT782_RS07300	COG3281	Trehalose synthase
IT782_RS07305	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IT782_RS07395	COG1119	ATPase activity
IT782_RS07415	COG1301	dicarboxylic acid transport
IT782_RS07420	COG3290	protein histidine kinase activity
IT782_RS07425	COG4565	transcriptional regulatory protein
IT782_RS07430	COG0205	6-phosphofructokinase activity
IT782_RS07435	COG0857	belongs to the CobB CobQ family
IT782_RS07435	COG0280	phosphate acetyltransferase
IT782_RS07440	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IT782_RS07480	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IT782_RS07480	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IT782_RS07545	COG1335	isochorismatase
IT782_RS07550	COG2205	protein histidine kinase activity
IT782_RS07580	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IT782_RS07585	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IT782_RS07600	COG0183	Belongs to the thiolase family
IT782_RS07620	COG1131	(ABC) transporter
IT782_RS07655	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
IT782_RS07670	COG1250	3-hydroxyacyl-CoA dehydrogenase
IT782_RS07685	COG4585	Histidine kinase
IT782_RS07690	COG2197	response regulator
IT782_RS07710	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IT782_RS07715	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IT782_RS07720	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IT782_RS07725	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IT782_RS07730	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IT782_RS07735	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IT782_RS07740	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IT782_RS07755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IT782_RS07760	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IT782_RS07770	COG2890	protein-(glutamine-N5) methyltransferase activity
IT782_RS07775	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IT782_RS07780	COG0254	rRNA binding
IT782_RS07785	COG1316	TRANSCRIPTIONal
IT782_RS07795	COG0083	homoserine kinase activity
IT782_RS07800	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IT782_RS07805	COG0460	homoserine dehydrogenase
IT782_RS07810	COG0019	diaminopimelate decarboxylase activity
IT782_RS07815	COG0018	arginyl-trna synthetase
IT782_RS07845	COG3547	Transposase (IS116 IS110 IS902 family)
IT782_RS07855	COG1012	belongs to the aldehyde dehydrogenase family
IT782_RS07865	COG1191	sigma factor activity
IT782_RS07870	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IT782_RS07870	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IT782_RS07880	COG2267	carboxylic ester hydrolase activity
IT782_RS07885	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IT782_RS07890	COG3285	dna ligase
IT782_RS07890	COG1793	dna ligase
IT782_RS07900	COG0772	Belongs to the SEDS family
IT782_RS07905	COG0768	penicillin binding
IT782_RS07980	COG0726	polysaccharide deacetylase
IT782_RS07985	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IT782_RS07990	COG0477	Major facilitator Superfamily
IT782_RS08005	COG1595	DNA-templated transcription, initiation
IT782_RS08015	COG1131	(ABC) transporter
IT782_RS08035	COG0745	RESPONSE REGULATOR receiver
IT782_RS08040	COG2205	protein histidine kinase activity
IT782_RS08045	COG0508	dehydrogenase complex catalyzes the overall conversion of
IT782_RS08045	COG0567	Dehydrogenase, E1 component
IT782_RS08075	COG2255	four-way junction helicase activity
IT782_RS08115	COG0604	alcohol dehydrogenase
IT782_RS08120	COG0281	malic enzyme
IT782_RS08125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IT782_RS08135	COG1126	abc transporter atp-binding protein
IT782_RS08140	COG4106	trans-aconitate 2-methyltransferase activity
IT782_RS08165	COG0789	Transcriptional regulator
IT782_RS08190	COG0142	geranyltranstransferase activity
IT782_RS08200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IT782_RS08205	COG1959	2 iron, 2 sulfur cluster binding
IT782_RS08225	COG2515	1-aminocyclopropane-1-carboxylate deaminase
IT782_RS08240	COG2172	sigma factor antagonist activity
IT782_RS08255	COG1597	lipid kinase activity
IT782_RS08270	COG0363	glucosamine-6-phosphate deaminase activity
IT782_RS08275	COG1472	Belongs to the glycosyl hydrolase 3 family
IT782_RS08280	COG0395	ABC-type sugar transport system, permease component
IT782_RS08285	COG1175	transmembrane transport
IT782_RS08290	COG2182	Extracellular solute-binding protein
IT782_RS08295	COG2188	Transcriptional regulator
IT782_RS08300	COG1966	Carbon starvation protein
IT782_RS08320	COG2124	cytochrome p450
IT782_RS08330	COG0242	peptide deformylase activity
IT782_RS08340	COG5662	AntiSigma factor
IT782_RS08345	COG1595	DNA-templated transcription, initiation
IT782_RS08355	COG2135	peptidase activity
IT782_RS08365	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IT782_RS08375	COG2076	Multidrug Resistance protein
IT782_RS08385	COG0483	inositol monophosphate 1-phosphatase activity
IT782_RS08390	COG0753	catalase activity
IT782_RS08415	COG1615	UPF0182 protein
IT782_RS08425	COG3480	Lon protease (S16) C-terminal proteolytic domain
IT782_RS08480	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IT782_RS08520	COG0210	DNA helicase
IT782_RS08545	COG0596	Alpha beta hydrolase
IT782_RS08610	COG0513	Belongs to the DEAD box helicase family
IT782_RS08620	COG1432	Conserved Protein
IT782_RS08630	COG2095	MarC family integral membrane protein
IT782_RS08635	COG0613	PHP domain protein
IT782_RS08640	COG2814	Major facilitator Superfamily
IT782_RS08650	COG0598	Magnesium transport protein CorA
IT782_RS08690	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IT782_RS08705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IT782_RS08715	COG1595	DNA-templated transcription, initiation
IT782_RS08730	COG1024	Enoyl-CoA hydratase
IT782_RS08740	COG0519	Catalyzes the synthesis of GMP from XMP
IT782_RS08765	COG2207	Transcriptional regulator
IT782_RS08770	COG1611	Belongs to the LOG family
IT782_RS08775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IT782_RS08810	COG2912	Transglutaminase-like superfamily
IT782_RS08820	COG1609	Transcriptional regulator
IT782_RS08825	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT782_RS08835	COG1129	ABC transporter
IT782_RS08840	COG1879	ABC-type sugar transport system periplasmic component
IT782_RS08845	COG3250	beta-galactosidase activity
IT782_RS08865	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IT782_RS08885	COG4608	Belongs to the ABC transporter superfamily
IT782_RS08895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT782_RS08900	COG0601	transmembrane transport
IT782_RS08910	COG4608	Belongs to the ABC transporter superfamily
IT782_RS08915	COG0444	Belongs to the ABC transporter superfamily
IT782_RS08920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT782_RS08925	COG0601	transmembrane transport
IT782_RS08935	COG1217	gtp-binding protein TYPA
IT782_RS08990	COG1554	hydrolase, family 65, central catalytic
IT782_RS09040	COG1028	Short-chain dehydrogenase reductase Sdr
IT782_RS09045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IT782_RS09055	COG3473	Maleate cis-trans isomerase
IT782_RS09060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IT782_RS09075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IT782_RS09080	COG0765	amino acid transport
IT782_RS09085	COG0765	amino acid transport
IT782_RS09090	COG1126	abc transporter atp-binding protein
IT782_RS09120	COG3397	chitin binding
IT782_RS09175	COG0673	inositol 2-dehydrogenase activity
IT782_RS09180	COG0179	Fumarylacetoacetate (FAA) hydrolase
IT782_RS09185	COG0706	membrane insertase activity
IT782_RS09230	COG2271	Major facilitator Superfamily
IT782_RS09240	COG2733	membrane
IT782_RS09270	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IT782_RS09280	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IT782_RS09305	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IT782_RS09315	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IT782_RS09320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IT782_RS09325	COG1263	PTS System
IT782_RS09335	COG1234	tRNA 3'-trailer cleavage
IT782_RS09360	COG1113	amino acid transport
IT782_RS09375	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IT782_RS09385	COG1335	isochorismatase
IT782_RS09420	COG0277	FAD linked oxidase domain protein
IT782_RS09430	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IT782_RS09440	COG1174	glycine betaine transport
IT782_RS09445	COG0517	IMP dehydrogenase activity
IT782_RS09445	COG1125	glycine betaine transport
IT782_RS09500	COG2318	DinB family
IT782_RS09525	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IT782_RS09530	COG2318	DinB family
IT782_RS09545	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IT782_RS09560	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IT782_RS09565	COG0395	ABC-type sugar transport system, permease component
IT782_RS09570	COG1175	transmembrane transport
IT782_RS09585	COG1678	Uncharacterized ACR, COG1678
IT782_RS09590	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IT782_RS09595	COG0776	regulation of translation
IT782_RS09605	COG3973	AAA domain
IT782_RS09605	COG3973	AAA domain
IT782_RS09650	COG0583	DNA-binding transcription factor activity
IT782_RS09665	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IT782_RS09670	COG0793	Belongs to the peptidase S41A family
IT782_RS09680	COG2884	Cell division ATP-binding protein ftsE
IT782_RS09695	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IT782_RS09700	COG0515	serine threonine protein kinase
IT782_RS09705	COG0515	serine threonine protein kinase
IT782_RS09710	COG1716	ATPase activity
IT782_RS09715	COG1653	transport
IT782_RS09720	COG1175	transmembrane transport
IT782_RS09725	COG0395	ABC-type sugar transport system, permease component
IT782_RS09730	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IT782_RS09735	COG0438	transferase activity, transferring glycosyl groups
IT782_RS09740	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IT782_RS09745	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IT782_RS09755	COG2226	methyltransferase
IT782_RS09770	COG2902	Dehydrogenase
IT782_RS09790	COG0583	DNA-binding transcription factor activity
IT782_RS09795	COG0653	protein targeting
IT782_RS09800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IT782_RS09805	COG3214	Protein conserved in bacteria
IT782_RS09810	COG2197	response regulator
IT782_RS09815	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IT782_RS09825	COG0823	Involved in the tonB-independent uptake of proteins
IT782_RS09830	COG5002	protein histidine kinase activity
IT782_RS09835	COG0745	RESPONSE REGULATOR receiver
IT782_RS09840	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IT782_RS09860	COG0714	Associated with various cellular activities
IT782_RS09865	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
IT782_RS09915	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IT782_RS09925	COG1482	cell wall glycoprotein biosynthetic process
IT782_RS09935	COG2835	tetraacyldisaccharide 4'-kinase activity
IT782_RS09945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IT782_RS09955	COG1620	l-lactate permease
IT782_RS09990	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IT782_RS09995	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
IT782_RS09995	COG0778	Nitroreductase
IT782_RS10025	COG1316	TRANSCRIPTIONal
IT782_RS10045	COG1316	TRANSCRIPTIONal
IT782_RS10050	COG3046	protein related to deoxyribodipyrimidine photolyase
IT782_RS10080	COG0753	catalase activity
IT782_RS10110	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IT782_RS10115	COG2197	response regulator
IT782_RS10120	COG4585	Histidine kinase
IT782_RS10125	COG0577	efflux transmembrane transporter activity
IT782_RS10125	COG1136	(ABC) transporter
IT782_RS10140	COG2072	flavoprotein involved in K transport
IT782_RS10180	COG2205	protein histidine kinase activity
IT782_RS10185	COG0745	RESPONSE REGULATOR receiver
IT782_RS10190	COG3104	oligopeptide transport
IT782_RS10195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IT782_RS10205	COG1366	Belongs to the anti-sigma-factor antagonist family
IT782_RS10210	COG1191	sigma factor activity
IT782_RS10215	COG1228	amidohydrolase
IT782_RS10245	COG0395	ABC-type sugar transport system, permease component
IT782_RS10315	COG2755	lipolytic protein G-D-S-L family
IT782_RS10320	COG0183	Belongs to the thiolase family
IT782_RS10345	COG1476	TRANSCRIPTIONal
IT782_RS10360	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IT782_RS10370	COG1136	(ABC) transporter
IT782_RS10375	COG0577	efflux transmembrane transporter activity
IT782_RS10375	COG1136	(ABC) transporter
IT782_RS10380	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IT782_RS10385	COG1252	NADH dehydrogenase
IT782_RS10420	COG0148	phosphopyruvate hydratase activity
IT782_RS10435	COG2124	cytochrome p450
IT782_RS10500	COG0667	Aldo Keto reductase
IT782_RS10535	COG0154	amidase activity
IT782_RS10540	COG3226	Transcriptional regulator
IT782_RS10550	COG1473	amidohydrolase
IT782_RS10570	COG3547	Transposase (IS116 IS110 IS902 family)
IT782_RS10605	COG3903	Transcriptional regulator
IT782_RS10605	COG3629	intracellular signal transduction
IT782_RS10615	COG0477	Major facilitator Superfamily
IT782_RS10650	COG2267	carboxylic ester hydrolase activity
IT782_RS10660	COG1316	TRANSCRIPTIONal
IT782_RS10705	COG4585	Histidine kinase
IT782_RS10715	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IT782_RS10720	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IT782_RS10740	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IT782_RS10745	COG0193	aminoacyl-tRNA hydrolase activity
IT782_RS10760	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IT782_RS10775	COG4106	trans-aconitate 2-methyltransferase activity
IT782_RS10785	COG2197	response regulator
IT782_RS10790	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IT782_RS10835	COG0488	(ABC) transporter
IT782_RS10840	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IT782_RS10845	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IT782_RS10850	COG0084	hydrolase, TatD family'
IT782_RS10920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IT782_RS10930	COG2409	Drug exporters of the RND superfamily
IT782_RS10940	COG4946	Tricorn protease homolog
IT782_RS10940	COG0793	Belongs to the peptidase S41A family
IT782_RS10950	COG4221	oxidoreductase activity
IT782_RS10960	COG2072	flavoprotein involved in K transport
IT782_RS10970	COG0708	Exodeoxyribonuclease III
IT782_RS10980	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IT782_RS11000	COG2197	response regulator
IT782_RS11030	COG0521	Mo-molybdopterin cofactor biosynthetic process
IT782_RS11030	COG0315	cyclic pyranopterin monophosphate synthase activity
IT782_RS11035	COG0315	cyclic pyranopterin monophosphate synthase activity
IT782_RS11045	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IT782_RS11050	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IT782_RS11060	COG3263	regulation of cellular component size
IT782_RS11075	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IT782_RS11085	COG1970	mechanosensitive ion channel activity
IT782_RS11100	COG3191	aminopeptidase activity
IT782_RS11120	COG3384	dioxygenase
IT782_RS11125	COG1846	Transcriptional regulator
IT782_RS11180	COG2050	protein possibly involved in aromatic compounds catabolism
IT782_RS11190	COG0183	Belongs to the thiolase family
IT782_RS11195	COG1024	Enoyl-CoA hydratase
IT782_RS11200	COG1250	3-hydroxyacyl-CoA dehydrogenase
IT782_RS11205	COG3396	Phenylacetate-CoA oxygenase
IT782_RS11210	COG3460	Phenylacetate-CoA oxygenase
IT782_RS11215	COG3396	Phenylacetate-CoA oxygenase
IT782_RS11220	COG2151	metal-sulfur cluster biosynthetic enzyme
IT782_RS11225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IT782_RS11265	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IT782_RS11270	COG0191	fructose-bisphosphate aldolase activity
IT782_RS11275	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IT782_RS11300	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IT782_RS11330	COG0515	serine threonine protein kinase
IT782_RS11330	COG2815	serine threonine protein kinase
IT782_RS11345	COG1278	Cold shock
IT782_RS11425	COG5297	Belongs to the glycosyl hydrolase family 6
IT782_RS11445	COG0148	phosphopyruvate hydratase activity
IT782_RS11460	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IT782_RS11500	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IT782_RS11505	COG1609	Transcriptional regulator
IT782_RS11520	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IT782_RS11525	COG1028	Short-chain dehydrogenase reductase Sdr
IT782_RS11535	COG0477	Major facilitator Superfamily
IT782_RS11550	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IT782_RS11590	COG0515	serine threonine protein kinase
IT782_RS11590	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IT782_RS11595	COG1309	transcriptional regulator
IT782_RS11615	COG2072	flavoprotein involved in K transport
IT782_RS11620	COG2271	Major facilitator Superfamily
IT782_RS11640	COG1366	Belongs to the anti-sigma-factor antagonist family
IT782_RS11720	COG4821	SIS domain
IT782_RS11730	COG0259	pyridoxamine-phosphate oxidase activity
IT782_RS11765	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IT782_RS11820	COG0583	DNA-binding transcription factor activity
IT782_RS11825	COG0277	FAD linked oxidase domain protein
IT782_RS11830	COG2205	protein histidine kinase activity
IT782_RS11850	COG2124	cytochrome p450
IT782_RS11855	COG2124	cytochrome p450
IT782_RS11860	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IT782_RS11955	COG0667	Aldo Keto reductase
IT782_RS11980	COG2252	PERMEase
IT782_RS11990	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IT782_RS12015	COG2814	Major facilitator Superfamily
IT782_RS12025	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IT782_RS12030	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
IT782_RS12035	COG1278	Cold shock
IT782_RS12045	COG2197	response regulator
IT782_RS12050	COG1132	(ABC) transporter
IT782_RS12065	COG0515	serine threonine protein kinase
IT782_RS12070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IT782_RS12075	COG1120	ATPase activity
IT782_RS12080	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT782_RS12085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT782_RS12110	COG2124	cytochrome p450
IT782_RS12155	COG1061	Type III restriction enzyme res subunit
IT782_RS12230	COG3973	AAA domain
IT782_RS12320	COG0406	alpha-ribazole phosphatase activity
IT782_RS12330	COG1737	Transcriptional regulator
IT782_RS12335	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IT782_RS12340	COG1263	PTS System
IT782_RS12340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IT782_RS12345	COG0667	Aldo Keto reductase
IT782_RS12380	COG1278	Cold shock
IT782_RS12395	COG0463	Glycosyl transferase, family 2
IT782_RS12475	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IT782_RS12510	COG1105	Belongs to the carbohydrate kinase PfkB family
IT782_RS12535	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IT782_RS12565	COG1063	alcohol dehydrogenase
IT782_RS12580	COG1309	transcriptional regulator
IT782_RS12630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IT782_RS12755	COG1136	(ABC) transporter
IT782_RS12755	COG0577	efflux transmembrane transporter activity
IT782_RS12760	COG0577	efflux transmembrane transporter activity
IT782_RS12820	COG0604	alcohol dehydrogenase
IT782_RS12825	COG4585	Histidine kinase
IT782_RS12830	COG2197	response regulator
IT782_RS12835	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IT782_RS12840	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IT782_RS12860	COG0301	tRNA thio-modification
IT782_RS12880	COG0513	Belongs to the DEAD box helicase family
IT782_RS12885	COG1278	Cold shock
IT782_RS12915	COG2770	Histidine kinase
IT782_RS12915	COG2208	phosphoserine phosphatase activity
IT782_RS12960	COG3842	ATPase activity
IT782_RS12970	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IT782_RS12980	COG1253	flavin adenine dinucleotide binding
IT782_RS12995	COG0215	cysteine-tRNA ligase activity
IT782_RS13010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT782_RS13030	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IT782_RS13035	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IT782_RS13040	COG1329	Transcriptional regulator
IT782_RS13050	COG0745	RESPONSE REGULATOR receiver
IT782_RS13055	COG5002	protein histidine kinase activity
IT782_RS13060	COG0704	Plays a role in the regulation of phosphate uptake
IT782_RS13070	COG2076	Multidrug Resistance protein
IT782_RS13105	COG0588	phosphoglycerate mutase activity
IT782_RS13130	COG0438	transferase activity, transferring glycosyl groups
IT782_RS13165	COG1309	transcriptional regulator
IT782_RS13185	COG2226	methyltransferase
IT782_RS13195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IT782_RS13270	COG0789	Transcriptional regulator
IT782_RS13285	COG1490	D-aminoacyl-tRNA deacylase activity
IT782_RS13290	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IT782_RS13295	COG0735	belongs to the Fur family
IT782_RS13300	COG3485	protocatechuate 3,4-dioxygenase
IT782_RS13335	COG2897	thiosulfate sulfurtransferase activity
IT782_RS13360	COG0745	RESPONSE REGULATOR receiver
IT782_RS13365	COG1609	Transcriptional regulator
IT782_RS13370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IT782_RS13375	COG0745	RESPONSE REGULATOR receiver
IT782_RS13390	COG4214	carbohydrate transport
IT782_RS13395	COG1129	ABC transporter
IT782_RS13405	COG1609	Transcriptional regulator
IT782_RS13420	COG2160	L-arabinose isomerase activity
IT782_RS13425	COG0235	Class ii aldolase
IT782_RS13430	COG0737	Belongs to the 5'-nucleotidase family
IT782_RS13435	COG0456	acetyltransferase
IT782_RS13460	COG4941	Belongs to the sigma-70 factor family
IT782_RS13465	COG1725	Transcriptional regulator
IT782_RS13475	COG1131	(ABC) transporter
IT782_RS13495	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IT782_RS13520	COG2267	carboxylic ester hydrolase activity
IT782_RS13555	COG1595	DNA-templated transcription, initiation
IT782_RS13600	COG3903	Transcriptional regulator
IT782_RS13600	COG3629	intracellular signal transduction
IT782_RS13605	COG0596	Alpha beta hydrolase
IT782_RS13615	COG2208	phosphoserine phosphatase activity
IT782_RS13615	COG2770	Histidine kinase
IT782_RS13665	COG2318	DinB family
IT782_RS13670	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IT782_RS13680	COG0494	nUDIX hydrolase
IT782_RS13680	COG0406	alpha-ribazole phosphatase activity
IT782_RS13700	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IT782_RS13705	COG0306	phosphate transporter
IT782_RS13715	COG1937	Protein conserved in bacteria
IT782_RS13725	COG1028	Short-chain dehydrogenase reductase Sdr
IT782_RS13740	COG0671	phosphoesterase, PA-phosphatase related
IT782_RS13745	COG1196	nuclear chromosome segregation
IT782_RS13745	COG0741	lytic transglycosylase activity
IT782_RS13745	COG0739	heme binding
IT782_RS13760	COG2318	DinB family
IT782_RS13770	COG0509	glycine decarboxylation via glycine cleavage system
IT782_RS13820	COG2175	clavaminate synthase activity
IT782_RS13825	COG3251	PFAM MbtH domain protein
IT782_RS13830	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IT782_RS13850	COG0577	efflux transmembrane transporter activity
IT782_RS13850	COG1136	(ABC) transporter
IT782_RS13890	COG2124	cytochrome p450
IT782_RS13895	COG0596	Alpha beta hydrolase
IT782_RS13910	COG0798	PFAM Bile acid sodium symporter
IT782_RS13915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IT782_RS13930	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IT782_RS13950	COG2197	response regulator
IT782_RS13955	COG4585	Histidine kinase
IT782_RS13960	COG0702	epimerase
IT782_RS13970	COG3844	kynureninase activity
IT782_RS13990	COG0477	Major facilitator Superfamily
IT782_RS13995	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IT782_RS14000	COG0191	fructose-bisphosphate aldolase activity
IT782_RS14005	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IT782_RS14050	COG2378	regulation of single-species biofilm formation
IT782_RS14065	COG0477	Major facilitator Superfamily
IT782_RS14095	COG0789	Transcriptional regulator
IT782_RS14105	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IT782_RS14110	COG0443	Heat shock 70 kDa protein
IT782_RS14145	COG1725	Transcriptional regulator
IT782_RS14150	COG1131	(ABC) transporter
IT782_RS14165	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
IT782_RS14170	COG1120	ATPase activity
IT782_RS14175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT782_RS14180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT782_RS14220	COG1695	Transcriptional regulator
IT782_RS14230	COG2814	Major facilitator Superfamily
IT782_RS14250	COG0717	Belongs to the dCTP deaminase family
IT782_RS14280	COG0247	lactate metabolic process
IT782_RS14280	COG2181	nitrate reductase activity
IT782_RS14285	COG0657	acetylesterase activity
IT782_RS14310	COG0477	Major facilitator Superfamily
IT782_RS14320	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IT782_RS14360	COG1937	Protein conserved in bacteria
IT782_RS14365	COG2268	Band 7 protein
IT782_RS14380	COG1316	TRANSCRIPTIONal
IT782_RS14420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IT782_RS14430	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IT782_RS14445	COG1741	Belongs to the pirin family
IT782_RS14455	COG1960	acyl-CoA dehydrogenase activity
IT782_RS14475	COG1362	aminopeptidase activity
IT782_RS14535	COG0022	dehydrogenase e1 component
IT782_RS14550	COG0515	serine threonine protein kinase
IT782_RS14555	COG0515	serine threonine protein kinase
IT782_RS14580	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IT782_RS14585	COG0303	'Molybdopterin
IT782_RS14610	COG1522	sequence-specific DNA binding
IT782_RS14650	COG1733	regulation of RNA biosynthetic process
IT782_RS14655	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IT782_RS14665	COG1716	ATPase activity
IT782_RS14670	COG1716	ATPase activity
IT782_RS14690	COG0515	serine threonine protein kinase
IT782_RS14695	COG3764	Sortase (surface protein transpeptidase)
IT782_RS14700	COG3764	Sortase (surface protein transpeptidase)
IT782_RS14725	COG0705	Rhomboid family
IT782_RS14745	COG1309	transcriptional regulator
IT782_RS14750	COG1278	Cold shock
IT782_RS14815	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IT782_RS14820	COG0187	DNA topoisomerase II activity
IT782_RS14825	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
IT782_RS14830	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IT782_RS14835	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IT782_RS14840	COG0592	DNA-directed DNA polymerase activity
IT782_RS14845	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IT782_RS14850	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IT782_RS14855	COG0594	ribonuclease P activity
IT782_RS14860	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IT782_RS14865	COG0706	membrane insertase activity
IT782_RS14875	COG0357	Ribosomal RNA small subunit methyltransferase G
IT782_RS14880	COG1192	Involved in chromosome partitioning
IT782_RS14895	COG3118	belongs to the thioredoxin family
IT782_RS14900	COG0492	ferredoxin-NADP+ reductase activity
IT782_RS14910	COG1595	DNA-templated transcription, initiation
IT782_RS14915	COG0515	serine threonine protein kinase
IT782_RS14915	COG2815	serine threonine protein kinase
IT782_RS14930	COG0617	tRNA 3'-terminal CCA addition
IT782_RS14955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IT782_RS14980	COG0360	Binds together with S18 to 16S ribosomal RNA
IT782_RS14985	COG0629	single-stranded DNA binding
IT782_RS14990	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IT782_RS14995	COG0359	binds to the 23S rRNA
IT782_RS15005	COG0305	Participates in initiation and elongation during chromosome replication
IT782_RS15010	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IT782_RS15015	COG0110	maltose O-acetyltransferase activity
IT782_RS15055	COG0626	cystathionine gamma-synthase activity
IT782_RS15060	COG1950	PFAM Membrane protein of
IT782_RS15065	COG0662	Cupin 2, conserved barrel domain protein
IT782_RS15090	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IT782_RS15105	COG1609	Transcriptional regulator
IT782_RS15110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IT782_RS15115	COG1271	oxidase subunit
IT782_RS15120	COG1294	oxidase, subunit
IT782_RS15125	COG4988	ABC transporter
IT782_RS15135	COG1196	nuclear chromosome segregation
IT782_RS15135	COG0739	heme binding
IT782_RS15135	COG0741	lytic transglycosylase activity
IT782_RS15140	COG0561	phosphatase activity
IT782_RS15160	COG1131	(ABC) transporter
IT782_RS15180	COG0561	phosphatase activity
IT782_RS15185	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IT782_RS15190	COG0077	Prephenate dehydratase
IT782_RS15195	COG2837	iron assimilation
IT782_RS15210	COG1999	signal sequence binding
IT782_RS15230	COG0006	proline dipeptidase activity
IT782_RS15245	COG0653	protein targeting
IT782_RS15260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IT782_RS15280	COG1595	DNA-templated transcription, initiation
IT782_RS15285	COG0318	PFAM AMP-dependent synthetase and ligase
IT782_RS15320	COG0745	RESPONSE REGULATOR receiver
IT782_RS15330	COG0477	Major facilitator Superfamily
IT782_RS15350	COG0477	Major facilitator Superfamily
IT782_RS15365	COG1191	sigma factor activity
IT782_RS15370	COG1191	sigma factor activity
IT782_RS15405	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IT782_RS15470	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IT782_RS15495	COG2188	Transcriptional regulator
IT782_RS15530	COG1196	nuclear chromosome segregation
IT782_RS15590	COG0151	Belongs to the GarS family
IT782_RS15605	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IT782_RS15615	COG2197	response regulator
IT782_RS15650	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IT782_RS15655	COG0047	phosphoribosylformylglycinamidine synthase activity
IT782_RS15660	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IT782_RS15675	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IT782_RS15715	COG1643	Atp-dependent helicase
IT782_RS15755	COG0513	Belongs to the DEAD box helicase family
IT782_RS15785	COG0542	response to heat
IT782_RS15795	COG2261	transglycosylase associated protein
IT782_RS15815	COG0667	Aldo Keto reductase
IT782_RS15825	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IT782_RS15830	COG0579	oxidoreductase
IT782_RS15845	COG1470	cell adhesion involved in biofilm formation
IT782_RS15845	COG0366	Alpha amylase catalytic
IT782_RS15920	COG0596	Alpha beta hydrolase
IT782_RS15935	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IT782_RS15940	COG3547	Transposase (IS116 IS110 IS902 family)
IT782_RS15990	COG2197	response regulator
IT782_RS16005	COG0666	response to abiotic stimulus
IT782_RS16075	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IT782_RS16080	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IT782_RS16090	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IT782_RS16135	COG0596	Alpha beta hydrolase
IT782_RS16160	COG2318	DinB family
IT782_RS16175	COG0577	efflux transmembrane transporter activity
IT782_RS16175	COG1136	(ABC) transporter
IT782_RS16190	COG1408	metallophosphoesterase
IT782_RS16210	COG0003	Pfam Anion-transporting ATPase
IT782_RS16225	COG0251	oxidation-reduction process
IT782_RS16235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IT782_RS16260	COG2267	carboxylic ester hydrolase activity
IT782_RS16270	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IT782_RS16275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IT782_RS16280	COG0659	secondary active sulfate transmembrane transporter activity
IT782_RS16340	COG1111	helicase
IT782_RS16340	COG1205	dead DEAH box helicase
IT782_RS16345	COG1366	Belongs to the anti-sigma-factor antagonist family
IT782_RS16360	COG2890	protein-(glutamine-N5) methyltransferase activity
IT782_RS16370	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IT782_RS16370	COG1754	DNA topoisomerase type I activity
IT782_RS16375	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IT782_RS16400	COG0789	Transcriptional regulator
IT782_RS16415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IT782_RS16420	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IT782_RS16435	COG0789	Transcriptional regulator
IT782_RS16445	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IT782_RS16445	COG0825	malonyl-CoA metabolic process
IT782_RS16450	COG0318	PFAM AMP-dependent synthetase and ligase
IT782_RS16460	COG2186	Transcriptional regulator
IT782_RS16475	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IT782_RS16485	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IT782_RS16530	COG0494	nUDIX hydrolase
IT782_RS16535	COG1252	NADH dehydrogenase
IT782_RS16540	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IT782_RS16550	COG1028	Short-chain dehydrogenase reductase Sdr
IT782_RS16555	COG0640	Transcriptional regulator
IT782_RS16565	COG1316	TRANSCRIPTIONal
IT782_RS16585	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IT782_RS16590	COG1309	transcriptional regulator
IT782_RS16600	COG5001	Diguanylate cyclase
IT782_RS16635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT782_RS16640	COG1120	ATPase activity
IT782_RS16645	COG0783	Belongs to the Dps family
IT782_RS16680	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IT782_RS16685	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IT782_RS16705	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IT782_RS16735	COG1214	PFAM Peptidase M22, glycoprotease
IT782_RS16735	COG0456	acetyltransferase
IT782_RS16775	COG0739	heme binding
IT782_RS16785	COG2814	Major facilitator Superfamily
IT782_RS16785	COG0477	Major facilitator Superfamily
IT782_RS16800	COG2159	amidohydrolase
IT782_RS16810	COG2186	Transcriptional regulator
IT782_RS16840	COG0501	Belongs to the peptidase M48B family
IT782_RS16845	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IT782_RS16845	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IT782_RS16875	COG1289	transmembrane transporter activity
IT782_RS16900	COG1012	belongs to the aldehyde dehydrogenase family
IT782_RS16905	COG2318	DinB family
IT782_RS16915	COG0655	NAD(P)H dehydrogenase (quinone) activity
IT782_RS16920	COG0789	Transcriptional regulator
IT782_RS16925	COG0586	Pfam SNARE associated Golgi protein
IT782_RS16935	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IT782_RS16940	COG2027	D-alanyl-D-alanine carboxypeptidase
IT782_RS16950	COG0037	tRNA processing
IT782_RS16965	COG0302	gtp cyclohydrolase
IT782_RS16980	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IT782_RS16995	COG1125	glycine betaine transport
IT782_RS16995	COG0517	IMP dehydrogenase activity
IT782_RS17000	COG1174	glycine betaine transport
IT782_RS17005	COG1174	glycine betaine transport
IT782_RS17010	COG1732	Glycine betaine
IT782_RS17020	COG0477	Major facilitator Superfamily
IT782_RS17095	COG1012	belongs to the aldehyde dehydrogenase family
IT782_RS17115	COG4585	Histidine kinase
IT782_RS17120	COG2197	response regulator
IT782_RS17140	COG0649	NAD binding
IT782_RS17155	COG2197	response regulator
IT782_RS17170	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IT782_RS17175	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IT782_RS17185	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IT782_RS17205	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IT782_RS17230	COG0739	heme binding
IT782_RS17235	COG2205	protein histidine kinase activity
IT782_RS17240	COG0745	RESPONSE REGULATOR receiver
IT782_RS17250	COG1595	DNA-templated transcription, initiation
IT782_RS17260	COG0671	phosphoesterase, PA-phosphatase related
IT782_RS17270	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
IT782_RS17300	COG0248	Ppx GppA phosphatase
IT782_RS17310	COG1082	Xylose isomerase domain protein TIM barrel
IT782_RS17315	COG1309	transcriptional regulator
IT782_RS17320	COG0129	dihydroxy-acid dehydratase activity
IT782_RS17330	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IT782_RS17350	COG1129	ABC transporter
IT782_RS17350	COG0842	Transport permease protein
IT782_RS17360	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IT782_RS17365	COG0180	Tryptophanyl-tRNA synthetase
IT782_RS17385	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IT782_RS17395	COG0123	including yeast histone deacetylase and acetoin utilization protein
IT782_RS17425	COG4552	Acetyltransferase involved in intracellular survival and related
IT782_RS17450	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
IT782_RS17455	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IT782_RS17460	COG0181	hydroxymethylbilane synthase activity
IT782_RS17465	COG1648	precorrin-2 dehydrogenase activity
IT782_RS17465	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IT782_RS17470	COG0113	porphobilinogen synthase activity
IT782_RS17500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IT782_RS17505	COG0018	arginyl-trna synthetase
IT782_RS17510	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
IT782_RS17535	COG1690	Belongs to the RtcB family
IT782_RS17540	COG0659	secondary active sulfate transmembrane transporter activity
IT782_RS17585	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IT782_RS17590	COG0406	alpha-ribazole phosphatase activity
IT782_RS17615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IT782_RS17620	COG0785	Cytochrome C biogenesis protein
IT782_RS17630	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IT782_RS17645	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IT782_RS17650	COG0109	protoheme IX farnesyltransferase activity
IT782_RS17655	COG0163	prenyltransferase activity
IT782_RS17670	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IT782_RS17685	COG1301	dicarboxylic acid transport
IT782_RS17765	COG0183	Belongs to the thiolase family
IT782_RS17775	COG1278	Cold shock
IT782_RS17780	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
IT782_RS17785	COG1674	ftsk spoiiie
IT782_RS17915	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IT782_RS17925	COG2226	methyltransferase
IT782_RS17950	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IT782_RS17955	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IT782_RS17970	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IT782_RS17975	COG1034	ATP synthesis coupled electron transport
IT782_RS17980	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IT782_RS17985	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IT782_RS17990	COG0839	Belongs to the complex I subunit 6 family
IT782_RS17995	COG0713	ATP synthesis coupled electron transport
IT782_RS18000	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IT782_RS18010	COG1007	ATP synthesis coupled electron transport
IT782_RS18035	COG0561	phosphatase activity
IT782_RS18045	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IT782_RS18055	COG3104	oligopeptide transport
IT782_RS18060	COG0142	geranyltranstransferase activity
IT782_RS18080	COG0488	(ABC) transporter
IT782_RS18090	COG0702	epimerase
IT782_RS18095	COG1733	regulation of RNA biosynthetic process
IT782_RS18100	COG1013	pyruvate-flavodoxin oxidoreductase activity
IT782_RS18105	COG0674	pyruvate-flavodoxin oxidoreductase activity
IT782_RS18105	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IT782_RS18110	COG2197	response regulator
IT782_RS18115	COG4585	Histidine kinase
IT782_RS18120	COG4585	Histidine kinase
IT782_RS18125	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IT782_RS18130	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IT782_RS18135	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IT782_RS18140	COG0839	Belongs to the complex I subunit 6 family
IT782_RS18145	COG0713	ATP synthesis coupled electron transport
IT782_RS18150	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IT782_RS18160	COG1007	ATP synthesis coupled electron transport
IT782_RS18165	COG0501	Belongs to the peptidase M48B family
IT782_RS18170	COG3304	Inner membrane component domain
IT782_RS18175	COG2261	transglycosylase associated protein
IT782_RS18180	COG1666	GTP binding
IT782_RS18190	COG0702	epimerase
IT782_RS18195	COG0402	S-adenosylhomocysteine deaminase activity
IT782_RS18210	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IT782_RS18215	COG2030	dehydratase
IT782_RS18225	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IT782_RS18235	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IT782_RS18240	COG0436	Aminotransferase
IT782_RS18265	COG0081	regulation of translation
IT782_RS18275	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IT782_RS18280	COG0222	ribosome binding
IT782_RS18285	COG0085	RNA polymerase activity
IT782_RS18290	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IT782_RS18325	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IT782_RS18330	COG0049	tRNA binding
IT782_RS18335	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IT782_RS18360	COG2814	Major facilitator Superfamily
IT782_RS18370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IT782_RS18375	COG3547	Transposase (IS116 IS110 IS902 family)
IT782_RS18385	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IT782_RS18395	COG0051	transcription antitermination factor activity, RNA binding
IT782_RS18400	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IT782_RS18405	COG0088	Forms part of the polypeptide exit tunnel
IT782_RS18410	COG0089	rRNA binding
IT782_RS18415	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IT782_RS18420	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IT782_RS18425	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IT782_RS18430	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IT782_RS18435	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IT782_RS18440	COG0255	Belongs to the universal ribosomal protein uL29 family
IT782_RS18445	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IT782_RS18450	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IT782_RS18455	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IT782_RS18460	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IT782_RS18465	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IT782_RS18470	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IT782_RS18475	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IT782_RS18480	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IT782_RS18485	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IT782_RS18490	COG1841	ribosomal large subunit assembly
IT782_RS18495	COG0200	Binds to the 23S rRNA
IT782_RS18500	COG0201	protein transport
IT782_RS18505	COG0563	adenylate kinase activity
IT782_RS18515	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IT782_RS18520	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IT782_RS18525	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IT782_RS18530	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IT782_RS18540	COG0203	ribosomal protein L17
IT782_RS18545	COG0101	tRNA pseudouridine synthase activity
IT782_RS18555	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IT782_RS18560	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IT782_RS18565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IT782_RS18570	COG1072	(Pantothenic acid kinase))
IT782_RS18580	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IT782_RS18590	COG4977	sequence-specific DNA binding
IT782_RS18605	COG0736	holo-[acyl-carrier-protein] synthase activity
IT782_RS18670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IT782_RS18680	COG0802	atpase or kinase
IT782_RS18705	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IT782_RS18740	COG0726	polysaccharide deacetylase
IT782_RS18755	COG4221	oxidoreductase activity
IT782_RS18760	COG0583	DNA-binding transcription factor activity
IT782_RS18770	COG2197	response regulator
IT782_RS18775	COG1595	DNA-templated transcription, initiation
IT782_RS18785	COG0516	GMP reductase activity
IT782_RS18795	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IT782_RS18830	COG1012	belongs to the aldehyde dehydrogenase family
IT782_RS18850	COG0519	Catalyzes the synthesis of GMP from XMP
IT782_RS18850	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IT782_RS18860	COG1028	Short-chain dehydrogenase reductase Sdr
IT782_RS18895	COG2197	response regulator
IT782_RS18900	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IT782_RS18945	COG1846	Transcriptional regulator
IT782_RS18945	COG0456	acetyltransferase
IT782_RS19005	COG2066	Belongs to the glutaminase family
IT782_RS19010	COG0741	lytic transglycosylase activity
IT782_RS19010	COG0739	heme binding
IT782_RS19010	COG1196	nuclear chromosome segregation
IT782_RS19015	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
IT782_RS19020	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IT782_RS19020	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IT782_RS19035	COG0714	Associated with various cellular activities
IT782_RS19040	COG2425	protein containing a von Willebrand factor type A (vWA) domain
IT782_RS19045	COG3552	Protein containing von Willebrand factor type A (VWA) domain
IT782_RS19050	COG0045	succinate-CoA ligase (ADP-forming) activity
IT782_RS19080	COG0138	bifunctional purine biosynthesis protein purh
IT782_RS19090	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IT782_RS19125	COG0039	L-malate dehydrogenase activity
IT782_RS19145	COG1012	belongs to the aldehyde dehydrogenase family
IT782_RS19155	COG4175	Glycine betaine
IT782_RS19155	COG0517	IMP dehydrogenase activity
IT782_RS19185	COG0395	ABC-type sugar transport system, permease component
IT782_RS19190	COG1175	transmembrane transport
IT782_RS19210	COG2362	D-Aminopeptidase
IT782_RS19215	COG1609	Transcriptional regulator
IT782_RS19220	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IT782_RS19225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IT782_RS19235	COG0754	glutathionylspermidine amidase activity
IT782_RS19245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IT782_RS19285	COG0180	Tryptophanyl-tRNA synthetase
IT782_RS19325	COG1295	ribonuclease BN
IT782_RS19330	COG1686	Belongs to the peptidase S11 family
IT782_RS19340	COG1408	metallophosphoesterase
IT782_RS19355	COG1309	transcriptional regulator
IT782_RS19370	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IT782_RS19375	COG1053	succinate dehydrogenase
IT782_RS19385	COG2009	succinate dehydrogenase
IT782_RS19425	COG1215	transferase activity, transferring glycosyl groups
IT782_RS19430	COG1595	DNA-templated transcription, initiation
IT782_RS19460	COG1216	Glycosyl transferase, family 2
IT782_RS19470	COG1083	cytidylyl-transferase
IT782_RS19475	COG2089	acid synthase
IT782_RS19485	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IT782_RS19485	COG1473	amidohydrolase
IT782_RS19505	COG2197	response regulator
IT782_RS19520	COG1744	ABC transporter substrate-binding protein PnrA-like
IT782_RS19525	COG3845	ABC transporter
IT782_RS19530	COG4603	Belongs to the binding-protein-dependent transport system permease family
IT782_RS19535	COG1079	Belongs to the binding-protein-dependent transport system permease family
IT782_RS19565	COG2814	Major facilitator Superfamily
IT782_RS19570	COG0583	DNA-binding transcription factor activity
IT782_RS19580	COG1136	(ABC) transporter
IT782_RS19600	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IT782_RS19630	COG0745	RESPONSE REGULATOR receiver
IT782_RS19635	COG1595	DNA-templated transcription, initiation
IT782_RS19680	COG1012	belongs to the aldehyde dehydrogenase family
IT782_RS19695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IT782_RS19730	COG4770	biotin carboxylase activity
IT782_RS19740	COG0424	maF-like protein
IT782_RS19755	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IT782_RS19765	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IT782_RS19770	COG1024	Enoyl-CoA hydratase
IT782_RS19780	COG2986	histidine ammonia-lyase
IT782_RS19800	COG1136	(ABC) transporter
IT782_RS19805	COG1064	alcohol dehydrogenase
IT782_RS19810	COG2318	DinB family
IT782_RS19855	COG2255	four-way junction helicase activity
IT782_RS19860	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IT782_RS19875	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IT782_RS19885	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IT782_RS19920	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IT782_RS19945	COG1331	Highly conserved protein containing a thioredoxin domain
IT782_RS19965	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
IT782_RS19995	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IT782_RS20010	COG1414	Transcriptional regulator
IT782_RS20015	COG0251	oxidation-reduction process
IT782_RS20055	COG2894	cell division
IT782_RS20120	COG2814	Major facilitator Superfamily
IT782_RS20125	COG0656	L-ascorbic acid biosynthetic process
IT782_RS20130	COG2304	oxidoreductase activity
IT782_RS20140	COG3548	integral membrane protein
IT782_RS20150	COG0667	Aldo Keto reductase
IT782_RS20155	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IT782_RS20160	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IT782_RS20180	COG0450	alkyl hydroperoxide reductase
IT782_RS20185	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IT782_RS20195	COG1136	(ABC) transporter
IT782_RS20215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IT782_RS20230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IT782_RS20240	COG0114	fumarate hydratase activity
IT782_RS20250	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IT782_RS20250	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IT782_RS20260	COG0515	serine threonine protein kinase
IT782_RS20285	COG0778	Nitroreductase
IT782_RS20290	COG1722	exodeoxyribonuclease VII activity
IT782_RS20295	COG1570	exodeoxyribonuclease VII activity
IT782_RS20305	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IT782_RS20320	COG0012	GTP binding
IT782_RS20360	COG0406	alpha-ribazole phosphatase activity
IT782_RS20385	COG0745	RESPONSE REGULATOR receiver
IT782_RS20450	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IT782_RS20455	COG4977	sequence-specific DNA binding
IT782_RS20470	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IT782_RS20495	COG3486	L-lysine 6-monooxygenase (NADPH) activity
IT782_RS20515	COG1028	Short-chain dehydrogenase reductase Sdr
IT782_RS20570	COG1960	acyl-CoA dehydrogenase activity
IT782_RS20585	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IT782_RS20590	COG1309	transcriptional regulator
IT782_RS20600	COG1946	Acyl-CoA thioesterase
IT782_RS20625	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IT782_RS20635	COG3960	tartronate-semialdehyde synthase activity
IT782_RS20655	COG1472	Belongs to the glycosyl hydrolase 3 family
IT782_RS20660	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IT782_RS20700	COG3718	enzyme involved in inositol metabolism
IT782_RS20705	COG3962	Belongs to the TPP enzyme family
IT782_RS20720	COG0456	acetyltransferase
IT782_RS20720	COG0454	-acetyltransferase
IT782_RS20725	COG1131	(ABC) transporter
IT782_RS20755	COG3903	Transcriptional regulator
IT782_RS20755	COG3629	intracellular signal transduction
IT782_RS20795	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IT782_RS20835	COG0629	single-stranded DNA binding
IT782_RS20875	COG1136	(ABC) transporter
IT782_RS20895	COG0667	Aldo Keto reductase
IT782_RS20900	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IT782_RS20930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IT782_RS20945	COG1486	melibiose metabolic process
IT782_RS20955	COG0668	transmembrane transport
IT782_RS20970	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IT782_RS20990	COG0583	DNA-binding transcription factor activity
IT782_RS21040	COG4266	Belongs to the allantoicase family
IT782_RS21070	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IT782_RS21080	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IT782_RS21085	COG1113	amino acid transport
IT782_RS21090	COG1113	amino acid transport
IT782_RS21095	COG1268	BioY protein
IT782_RS21100	COG1113	amino acid transport
IT782_RS21115	COG4552	Acetyltransferase involved in intracellular survival and related
IT782_RS21125	COG0475	glutathione-regulated potassium exporter activity
IT782_RS21130	COG3594	Acyltransferase
IT782_RS21150	COG0544	peptidyl-prolyl cis-trans isomerase activity
IT782_RS21155	COG0740	serine-type endopeptidase activity
IT782_RS21160	COG0740	serine-type endopeptidase activity
IT782_RS21165	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IT782_RS21175	COG0525	valine-tRNA ligase activity
IT782_RS21180	COG0285	dihydrofolate synthase activity
IT782_RS21190	COG0105	UTP biosynthetic process
IT782_RS21195	COG1077	Cell shape determining protein MreB Mrl
IT782_RS21215	COG0772	Belongs to the SEDS family
IT782_RS21245	COG1530	ribonuclease E activity
IT782_RS21250	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IT782_RS21255	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IT782_RS21260	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IT782_RS21280	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IT782_RS21290	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IT782_RS21310	COG0501	Belongs to the peptidase M48B family
IT782_RS21325	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IT782_RS21335	COG0799	negative regulation of ribosome biogenesis
IT782_RS21340	COG0588	phosphoglycerate mutase activity
IT782_RS21365	COG0495	leucyl-tRNA aminoacylation
IT782_RS21375	COG1307	EDD domain protein, DegV family
IT782_RS21380	COG1555	photosystem II stabilization
IT782_RS21410	COG0268	Binds directly to 16S ribosomal RNA
IT782_RS21415	COG0481	GTPase activity
IT782_RS21445	COG0484	heat shock protein binding
IT782_RS21460	COG4946	Tricorn protease homolog
IT782_RS21460	COG0793	Belongs to the peptidase S41A family
IT782_RS21470	COG0537	adenosine 5'-monophosphoramidase activity
IT782_RS21475	COG1234	tRNA 3'-trailer cleavage
IT782_RS21495	COG2515	1-aminocyclopropane-1-carboxylate deaminase
IT782_RS21500	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IT782_RS21525	COG1486	melibiose metabolic process
IT782_RS21530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IT782_RS21550	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IT782_RS21560	COG2315	Protein conserved in bacteria
IT782_RS21570	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IT782_RS21585	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IT782_RS21595	COG1381	Involved in DNA repair and RecF pathway recombination
IT782_RS21600	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IT782_RS21610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IT782_RS21615	COG1121	(ABC) transporter
IT782_RS21625	COG0423	glycine-tRNA ligase activity
IT782_RS21690	COG3467	pyridoxamine 5'-phosphate
IT782_RS21700	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
IT782_RS21705	COG1940	carbohydrate kinase activity
IT782_RS21705	COG1846	Transcriptional regulator
IT782_RS21715	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IT782_RS21715	COG0574	Belongs to the PEP-utilizing enzyme family
IT782_RS21730	COG1324	tolerance protein
IT782_RS21740	COG0829	nickel cation binding
IT782_RS21745	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IT782_RS21750	COG0830	nickel cation binding
IT782_RS21755	COG0804	urea catabolic process
IT782_RS21760	COG0832	Belongs to the urease beta subunit family
IT782_RS21780	COG2226	methyltransferase
IT782_RS21785	COG0736	holo-[acyl-carrier-protein] synthase activity
IT782_RS21790	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IT782_RS21800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IT782_RS21810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IT782_RS21815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IT782_RS21825	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IT782_RS21875	COG1070	Carbohydrate kinase
IT782_RS21895	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IT782_RS21900	COG0358	DNA primase activity
IT782_RS21910	COG3290	protein histidine kinase activity
IT782_RS21915	COG4565	transcriptional regulatory protein
IT782_RS21920	COG2851	Citrate transporter
IT782_RS21940	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IT782_RS21955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IT782_RS21985	COG1028	Short-chain dehydrogenase reductase Sdr
IT782_RS22000	COG2890	protein-(glutamine-N5) methyltransferase activity
IT782_RS22015	COG1077	Cell shape determining protein MreB Mrl
IT782_RS22040	COG2130	NADP-dependent
IT782_RS22045	COG1764	response to oxidative stress
IT782_RS22080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IT782_RS22085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IT782_RS22090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IT782_RS22105	COG1741	Belongs to the pirin family
IT782_RS22120	COG0789	Transcriptional regulator
IT782_RS22125	COG0667	Aldo Keto reductase
IT782_RS22140	COG2197	response regulator
IT782_RS22145	COG4585	Histidine kinase
IT782_RS22165	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IT782_RS22210	COG1358	cellular component organization or biogenesis
IT782_RS22225	COG0586	Pfam SNARE associated Golgi protein
IT782_RS22350	COG0438	transferase activity, transferring glycosyl groups
IT782_RS22380	COG0477	Major facilitator Superfamily
IT782_RS22385	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IT782_RS22390	COG1960	acyl-CoA dehydrogenase activity
IT782_RS22405	COG2197	response regulator
IT782_RS22410	COG4585	Histidine kinase
IT782_RS22420	COG1131	(ABC) transporter
IT782_RS22435	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IT782_RS22450	COG0800	Aldolase
IT782_RS22455	COG3022	response to hydroperoxide
IT782_RS22485	COG1733	regulation of RNA biosynthetic process
IT782_RS22505	COG2226	methyltransferase
IT782_RS22510	COG0384	phenazine biosynthesis protein PhzF
IT782_RS22530	COG0076	glutamate decarboxylase activity
IT782_RS22540	COG2814	Major facilitator Superfamily
IT782_RS22545	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IT782_RS22555	COG1834	amidinotransferase
IT782_RS22575	COG1120	ATPase activity
IT782_RS22580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT782_RS22585	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IT782_RS22600	COG0384	phenazine biosynthesis protein PhzF
IT782_RS22630	COG1994	Peptidase M50
IT782_RS22635	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IT782_RS22650	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IT782_RS22650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IT782_RS22655	COG2132	Multicopper oxidase
IT782_RS22675	COG0174	glutamine synthetase
IT782_RS22705	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IT782_RS22725	COG1228	amidohydrolase
IT782_RS22740	COG1609	Transcriptional regulator
IT782_RS22745	COG2182	Extracellular solute-binding protein
IT782_RS22750	COG1175	transmembrane transport
IT782_RS22755	COG0395	ABC-type sugar transport system, permease component
IT782_RS22760	COG0366	Alpha amylase catalytic
IT782_RS22785	COG1309	transcriptional regulator
IT782_RS22805	COG3293	Transposase
IT782_RS22825	COG0745	RESPONSE REGULATOR receiver
IT782_RS22860	COG1012	belongs to the aldehyde dehydrogenase family
IT782_RS22910	COG3547	Transposase (IS116 IS110 IS902 family)
IT782_RS22930	COG2326	polyphosphate kinase activity
IT782_RS22945	COG2376	Dihydroxyacetone kinase
IT782_RS22950	COG2376	Dihydroxyacetone kinase
IT782_RS22955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IT782_RS22990	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IT782_RS22995	COG0321	lipoyl(octanoyl) transferase activity
IT782_RS23045	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IT782_RS23055	COG0508	dehydrogenase complex catalyzes the overall conversion of
IT782_RS23060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IT782_RS23065	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IT782_RS23070	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IT782_RS23080	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IT782_RS23125	COG2197	response regulator
IT782_RS23130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IT782_RS23135	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IT782_RS23160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IT782_RS23165	COG1104	cysteine desulfurase activity
IT782_RS23170	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IT782_RS23175	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IT782_RS23185	COG1376	ErfK ybiS ycfS ynhG family protein
IT782_RS23195	COG1845	cytochrome c oxidase, subunit III
IT782_RS23200	COG2010	Cytochrome c
IT782_RS23205	COG0723	plastoquinol--plastocyanin reductase activity
IT782_RS23210	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IT782_RS23215	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IT782_RS23225	COG1929	Belongs to the glycerate kinase type-1 family
IT782_RS23235	COG0745	RESPONSE REGULATOR receiver
IT782_RS23240	COG5002	protein histidine kinase activity
IT782_RS23290	COG0438	transferase activity, transferring glycosyl groups
IT782_RS23320	COG1940	carbohydrate kinase activity
IT782_RS23345	COG4585	Histidine kinase
IT782_RS23350	COG2197	response regulator
IT782_RS23355	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IT782_RS23370	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IT782_RS23375	COG0243	molybdopterin cofactor binding
IT782_RS23380	COG2193	ferroxidase activity
IT782_RS23385	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IT782_RS23390	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IT782_RS23395	COG2815	serine threonine protein kinase
IT782_RS23395	COG0515	serine threonine protein kinase
IT782_RS23400	COG2022	thiamine diphosphate biosynthetic process
IT782_RS23410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IT782_RS23410	COG2022	thiamine diphosphate biosynthetic process
IT782_RS23415	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IT782_RS23425	COG0352	thiamine-phosphate diphosphorylase activity
IT782_RS23445	COG1309	transcriptional regulator
IT782_RS23455	COG1121	(ABC) transporter
IT782_RS23460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IT782_RS23480	COG0714	Associated with various cellular activities
IT782_RS23490	COG0275	rRNA processing
IT782_RS23500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IT782_RS23510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IT782_RS23515	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IT782_RS23525	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IT782_RS23530	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IT782_RS23535	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IT782_RS23540	COG1496	oxidoreductase activity
IT782_RS23550	COG1799	cell septum assembly
IT782_RS23560	COG3599	regulation of cell shape
IT782_RS23565	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IT782_RS23575	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IT782_RS23585	COG2153	protein acetylation
IT782_RS23600	COG0515	serine threonine protein kinase
IT782_RS23620	COG0587	DNA-directed DNA polymerase activity
IT782_RS23630	COG1432	Conserved Protein
IT782_RS23650	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IT782_RS23670	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IT782_RS23675	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IT782_RS23680	COG0131	Imidazoleglycerol-phosphate dehydratase
IT782_RS23690	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IT782_RS23695	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IT782_RS23700	COG0251	oxidation-reduction process
IT782_RS23705	COG0107	imidazoleglycerol-phosphate synthase activity
IT782_RS23720	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IT782_RS23730	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IT782_RS23750	COG0134	indole-3-glycerol-phosphate synthase activity
IT782_RS23755	COG0133	tryptophan synthase activity
IT782_RS23760	COG0159	tryptophan synthase activity
IT782_RS23770	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IT782_RS23780	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IT782_RS23805	COG1397	ADP-ribosylglycohydrolase
IT782_RS23815	COG0069	glutamate synthase activity
IT782_RS23815	COG0067	glutamate synthase
IT782_RS23815	COG0070	glutamate synthase
IT782_RS23830	COG1278	Cold shock
IT782_RS23835	COG0513	Belongs to the DEAD box helicase family
IT782_RS23845	COG0287	Prephenate dehydrogenase
IT782_RS23845	COG1605	Chorismate mutase
IT782_RS23880	COG0737	Belongs to the 5'-nucleotidase family
IT782_RS23920	COG0559	Belongs to the binding-protein-dependent transport system permease family
IT782_RS23935	COG2050	protein possibly involved in aromatic compounds catabolism
IT782_RS23955	COG1643	Atp-dependent helicase
IT782_RS23960	COG2226	methyltransferase
IT782_RS23980	COG0237	dephospho-CoA kinase activity
IT782_RS24000	COG1288	antiporter activity
IT782_RS24050	COG0477	Major facilitator Superfamily
IT782_RS24055	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IT782_RS24060	COG0584	glycerophosphoryl diester phosphodiesterase
IT782_RS24070	COG0556	nucleotide-excision repair
IT782_RS24090	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IT782_RS24095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IT782_RS24105	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IT782_RS24120	COG0322	excinuclease ABC activity
IT782_RS24125	COG1660	Displays ATPase and GTPase activities
IT782_RS24135	COG1481	regulation of sporulation
IT782_RS24140	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IT782_RS24145	COG0126	phosphoglycerate kinase activity
IT782_RS24150	COG0149	triose-phosphate isomerase activity
IT782_RS24155	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IT782_RS24165	COG0166	Belongs to the GPI family
IT782_RS24170	COG0363	glucosamine-6-phosphate deaminase activity
IT782_RS24185	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IT782_RS24190	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IT782_RS24195	COG0109	protoheme IX farnesyltransferase activity
IT782_RS24220	COG1131	(ABC) transporter
IT782_RS24235	COG0719	Fe-S assembly protein
IT782_RS24245	COG0396	ATPase activity
IT782_RS24250	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IT782_RS24255	COG0822	iron-sulfur transferase activity
IT782_RS24265	COG2171	N-acyltransferase activity
IT782_RS24300	COG2197	response regulator
IT782_RS24305	COG4585	Histidine kinase
IT782_RS24335	COG1902	pentaerythritol trinitrate reductase activity
IT782_RS24345	COG1917	Cupin 2, conserved barrel domain protein
IT782_RS24355	COG0456	acetyltransferase
IT782_RS24360	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IT782_RS24390	COG1797	cobyrinic acid a,c-diamide synthase activity
IT782_RS24405	COG1492	cobalamin metabolic process
IT782_RS24425	COG0235	Class ii aldolase
IT782_RS24450	COG0488	(ABC) transporter
IT782_RS24510	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IT782_RS24535	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IT782_RS24550	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IT782_RS24555	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IT782_RS24565	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IT782_RS24585	COG2261	transglycosylase associated protein
IT782_RS24590	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IT782_RS24600	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IT782_RS24610	COG2186	Transcriptional regulator
IT782_RS24615	COG2807	transmembrane transport
IT782_RS24630	COG0560	Phosphoserine phosphatase
IT782_RS24630	COG3830	Belongs to the UPF0237 family
IT782_RS24635	COG1131	(ABC) transporter
IT782_RS24635	COG0842	Transport permease protein
IT782_RS24635	COG1716	ATPase activity
IT782_RS24645	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IT782_RS24660	COG2197	response regulator
IT782_RS24675	COG1119	ATPase activity
IT782_RS24695	COG1881	PFAM PEBP family protein
IT782_RS24705	COG2094	Belongs to the DNA glycosylase MPG family
IT782_RS24740	COG0647	UMP catabolic process
IT782_RS24760	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IT782_RS24765	COG0497	DNA recombination
IT782_RS24780	COG0438	transferase activity, transferring glycosyl groups
IT782_RS24800	COG3387	PFAM Glycoside hydrolase 15-related
IT782_RS24805	COG0504	CTP synthase activity
IT782_RS24810	COG0494	nUDIX hydrolase
IT782_RS24820	COG0686	Belongs to the AlaDH PNT family
IT782_RS24835	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IT782_RS24840	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IT782_RS24845	COG1187	pseudouridine synthase activity
IT782_RS24855	COG1397	ADP-ribosylglycohydrolase
IT782_RS24860	COG3541	Predicted nucleotidyltransferase
IT782_RS24875	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IT782_RS24885	COG1160	GTP binding
IT782_RS24905	COG0438	transferase activity, transferring glycosyl groups
IT782_RS24925	COG0671	phosphoesterase, PA-phosphatase related
IT782_RS24935	COG0477	Major facilitator Superfamily
IT782_RS24940	COG1799	cell septum assembly
IT782_RS24955	COG0765	amino acid transport
IT782_RS24975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IT782_RS24995	COG0330	HflC and HflK could
IT782_RS25010	COG0587	DNA-directed DNA polymerase activity
IT782_RS25015	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IT782_RS25090	COG1216	Glycosyl transferase, family 2
IT782_RS25110	COG2755	lipolytic protein G-D-S-L family
IT782_RS25125	COG3973	AAA domain
IT782_RS25130	COG2188	Transcriptional regulator
IT782_RS25135	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IT782_RS25145	COG1309	transcriptional regulator
IT782_RS25190	COG3876	Protein conserved in bacteria
IT782_RS25200	COG0488	(ABC) transporter
IT782_RS25205	COG0110	maltose O-acetyltransferase activity
IT782_RS25215	COG0318	PFAM AMP-dependent synthetase and ligase
IT782_RS25225	COG1960	acyl-CoA dehydrogenase activity
IT782_RS25245	COG2149	membrane
IT782_RS25250	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IT782_RS25290	COG3265	gluconokinase activity
IT782_RS25300	COG3012	SEC-C Motif Domain Protein
IT782_RS25305	COG3189	MarR family transcriptional regulator
IT782_RS25315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IT782_RS25345	COG0667	Aldo Keto reductase
IT782_RS25350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IT782_RS25360	COG0598	Magnesium transport protein CorA
IT782_RS25380	COG0215	cysteine-tRNA ligase activity
IT782_RS25395	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IT782_RS25400	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IT782_RS25405	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IT782_RS25415	COG1410	methionine synthase
IT782_RS25415	COG0646	methionine synthase
IT782_RS25425	COG4166	transmembrane transport
IT782_RS25430	COG2197	response regulator
IT782_RS25440	COG0517	IMP dehydrogenase activity
IT782_RS25440	COG1994	Peptidase M50
IT782_RS25460	COG1222	aaa ATPase
IT782_RS25465	COG4122	O-methyltransferase activity
IT782_RS25475	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IT782_RS25480	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IT782_RS25495	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IT782_RS25530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IT782_RS25535	COG0805	protein transport
IT782_RS25550	COG2124	cytochrome p450
IT782_RS25580	COG0564	pseudouridine synthase activity
IT782_RS25600	COG1595	DNA-templated transcription, initiation
IT782_RS25610	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IT782_RS25615	COG0517	IMP dehydrogenase activity
IT782_RS25615	COG4175	Glycine betaine
IT782_RS25640	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IT782_RS25645	COG0531	amino acid
IT782_RS25650	COG2186	Transcriptional regulator
IT782_RS25655	COG0174	glutamine synthetase
IT782_RS25660	COG1012	belongs to the aldehyde dehydrogenase family
IT782_RS25695	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IT782_RS25705	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IT782_RS25710	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IT782_RS25715	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IT782_RS25720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IT782_RS25730	COG5002	protein histidine kinase activity
IT782_RS25735	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IT782_RS25740	COG0072	phenylalanine-tRNA ligase activity
IT782_RS25740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IT782_RS25775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IT782_RS25795	COG0426	domain, Protein
IT782_RS25795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IT782_RS25825	COG0667	Aldo Keto reductase
IT782_RS25870	COG0537	adenosine 5'-monophosphoramidase activity
IT782_RS25885	COG2249	NAD(P)H dehydrogenase (quinone) activity
IT782_RS25900	COG1028	Short-chain dehydrogenase reductase Sdr
IT782_RS25915	COG0697	spore germination
IT782_RS25920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IT782_RS25955	COG2838	Isocitrate dehydrogenase
IT782_RS25975	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IT782_RS25990	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IT782_RS25995	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IT782_RS26000	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IT782_RS26005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IT782_RS26010	COG1438	arginine binding
IT782_RS26015	COG4585	Histidine kinase
IT782_RS26020	COG2197	response regulator
IT782_RS26030	COG2409	Drug exporters of the RND superfamily
IT782_RS26035	COG0385	Bile acid
IT782_RS26045	COG0165	Argininosuccinate lyase
IT782_RS26065	COG0477	Major facilitator Superfamily
IT782_RS26070	COG0318	PFAM AMP-dependent synthetase and ligase
IT782_RS26070	COG0204	Acyl-transferase
IT782_RS26075	COG0584	glycerophosphoryl diester phosphodiesterase
IT782_RS26100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IT782_RS26105	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IT782_RS26110	COG2011	ABC-type metal ion transport system permease component
IT782_RS26115	COG1464	Belongs to the NlpA lipoprotein family
IT782_RS26120	COG1464	Belongs to the NlpA lipoprotein family
IT782_RS26135	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IT782_RS26140	COG1648	precorrin-2 dehydrogenase activity
IT782_RS26140	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IT782_RS26215	COG0456	acetyltransferase
IT782_RS26275	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IT782_RS26280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IT782_RS26295	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IT782_RS26300	COG1560	Kdo2-lipid A biosynthetic process
IT782_RS26305	COG0438	transferase activity, transferring glycosyl groups
IT782_RS26315	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
IT782_RS26320	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
IT782_RS26325	COG0217	transcriptional regulatory protein
IT782_RS26330	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IT782_RS26335	COG0632	four-way junction helicase activity
IT782_RS26340	COG2255	four-way junction helicase activity
IT782_RS26350	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IT782_RS26355	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IT782_RS26360	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IT782_RS26365	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IT782_RS26375	COG1196	nuclear chromosome segregation
IT782_RS26380	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IT782_RS26390	COG0124	histidyl-tRNA synthetase
IT782_RS26405	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IT782_RS26420	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IT782_RS26425	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IT782_RS26430	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IT782_RS26435	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IT782_RS26440	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IT782_RS26445	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IT782_RS26450	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IT782_RS26460	COG0006	proline dipeptidase activity
IT782_RS26465	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IT782_RS26470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IT782_RS26480	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IT782_RS26485	COG0540	Belongs to the ATCase OTCase family
IT782_RS26490	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IT782_RS26500	COG0505	Belongs to the CarA family
IT782_RS26505	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IT782_RS26510	COG0167	dihydroorotate dehydrogenase activity
IT782_RS26515	COG0284	orotidine-5'-phosphate decarboxylase activity
IT782_RS26530	COG1758	RNA polymerase activity
IT782_RS26540	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IT782_RS26555	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IT782_RS26570	COG2318	DinB family
IT782_RS26575	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IT782_RS26580	COG2390	Transcriptional regulator
IT782_RS26620	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IT782_RS26640	COG0697	spore germination
IT782_RS26645	COG2233	PERMEase
IT782_RS26655	COG0738	Major facilitator superfamily
IT782_RS26660	COG1846	Transcriptional regulator
IT782_RS26660	COG1940	carbohydrate kinase activity
IT782_RS26680	COG3201	nicotinamide mononucleotide transporter
IT782_RS26685	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IT782_RS26685	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IT782_RS26690	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IT782_RS26695	COG0140	phosphoribosyl-ATP diphosphatase activity
IT782_RS26700	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IT782_RS26730	COG1960	acyl-CoA dehydrogenase activity
IT782_RS26750	COG0463	Glycosyl transferase, family 2
IT782_RS26765	COG2270	Major facilitator Superfamily
IT782_RS26775	COG2364	Membrane
IT782_RS26780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IT782_RS26865	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IT782_RS26885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IT782_RS26895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IT782_RS26925	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IT782_RS26945	COG1716	ATPase activity
IT782_RS26965	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IT782_RS26975	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IT782_RS26975	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IT782_RS27030	COG0697	spore germination
IT782_RS27045	COG0697	spore germination
IT782_RS27065	COG4251	negative regulation of phosphorylation
IT782_RS27115	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IT782_RS27145	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IT782_RS27165	COG1982	Orn Lys Arg decarboxylase major
IT782_RS27175	COG1968	undecaprenyl-diphosphatase activity
IT782_RS27195	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IT782_RS27250	COG0110	maltose O-acetyltransferase activity
IT782_RS27260	COG1832	CoA-binding protein
IT782_RS27265	COG1739	Uncharacterized protein family UPF0029
IT782_RS27285	COG1595	DNA-templated transcription, initiation
IT782_RS27300	COG0420	3'-5' exonuclease activity
IT782_RS27305	COG0419	ATPase involved in DNA repair
IT782_RS27310	COG1522	sequence-specific DNA binding
IT782_RS27320	COG1028	Short-chain dehydrogenase reductase Sdr
IT782_RS27335	COG0626	cystathionine gamma-synthase activity
IT782_RS27360	COG2188	Transcriptional regulator
IT782_RS27365	COG1940	carbohydrate kinase activity
IT782_RS27385	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IT782_RS27415	COG0456	acetyltransferase
IT782_RS27420	COG0488	(ABC) transporter
IT782_RS27425	COG0488	(ABC) transporter
IT782_RS27435	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IT782_RS27440	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IT782_RS27445	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IT782_RS27475	COG0740	serine-type endopeptidase activity
IT782_RS27485	COG0831	urea catabolic process
IT782_RS27490	COG0832	Belongs to the urease beta subunit family
IT782_RS27495	COG0804	urea catabolic process
IT782_RS27505	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IT782_RS27510	COG0829	nickel cation binding
IT782_RS27550	COG1132	(ABC) transporter
IT782_RS27565	COG2175	clavaminate synthase activity
IT782_RS27570	COG0477	Major facilitator Superfamily
IT782_RS27575	COG0435	Glutathione S-transferase
IT782_RS27595	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IT782_RS27600	COG0583	DNA-binding transcription factor activity
IT782_RS27625	COG0205	6-phosphofructokinase activity
IT782_RS27630	COG3442	glutamine amidotransferase
IT782_RS27640	COG0242	peptide deformylase activity
IT782_RS27650	COG1960	acyl-CoA dehydrogenase activity
IT782_RS27670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IT782_RS27695	COG1175	transmembrane transport
IT782_RS27700	COG0395	ABC-type sugar transport system, permease component
IT782_RS27705	COG2723	6-phospho-beta-galactosidase activity
IT782_RS27710	COG0501	Belongs to the peptidase M48B family
IT782_RS27760	COG4251	negative regulation of phosphorylation
IT782_RS27765	COG0784	Response regulator, receiver
IT782_RS27785	COG0656	L-ascorbic acid biosynthetic process
IT782_RS27795	COG1595	DNA-templated transcription, initiation
IT782_RS27805	COG1132	(ABC) transporter
IT782_RS27825	COG3693	PFAM glycoside hydrolase, family 10
IT782_RS27835	COG1309	transcriptional regulator
IT782_RS27840	COG1131	(ABC) transporter
IT782_RS27845	COG3559	Exporter of polyketide antibiotics
IT782_RS27850	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IT782_RS27885	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IT782_RS27890	COG3279	Response regulator of the LytR AlgR family
IT782_RS27900	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IT782_RS27905	COG3275	phosphorelay sensor kinase activity
IT782_RS27970	COG0583	DNA-binding transcription factor activity
IT782_RS27980	COG1053	succinate dehydrogenase
IT782_RS27985	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IT782_RS27990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IT782_RS28000	COG3360	Dodecin
IT782_RS28005	COG2182	Extracellular solute-binding protein
IT782_RS28010	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IT782_RS28015	COG0121	glutamine amidotransferase
IT782_RS28020	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IT782_RS28040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IT782_RS28045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IT782_RS28050	COG1959	2 iron, 2 sulfur cluster binding
IT782_RS28055	COG1028	Short-chain dehydrogenase reductase Sdr
IT782_RS28080	COG2837	iron assimilation
IT782_RS28090	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IT782_RS28090	COG1796	DNA polymerase
IT782_RS28095	COG0142	geranyltranstransferase activity
IT782_RS28125	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
IT782_RS28135	COG2310	stress, protein
IT782_RS28150	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IT782_RS28160	COG0254	rRNA binding
IT782_RS28165	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IT782_RS28170	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IT782_RS28175	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IT782_RS28245	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IT782_RS28250	COG4948	Mandelate Racemase Muconate Lactonizing
IT782_RS28285	COG4257	antibiotic catabolic process
IT782_RS28295	COG0803	Belongs to the bacterial solute-binding protein 9 family
IT782_RS28305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IT782_RS28310	COG1121	(ABC) transporter
IT782_RS28315	COG4608	Belongs to the ABC transporter superfamily
IT782_RS28320	COG0444	Belongs to the ABC transporter superfamily
IT782_RS28330	COG0747	negative chemotaxis
IT782_RS28340	COG3458	cephalosporin-C deacetylase activity
IT782_RS28350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IT782_RS28360	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
IT782_RS28365	COG0363	glucosamine-6-phosphate deaminase activity
IT782_RS28370	COG0590	tRNA wobble adenosine to inosine editing
IT782_RS28375	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IT782_RS28405	COG2201	protein-glutamate methylesterase activity
IT782_RS28410	COG0300	oxidoreductase activity
IT782_RS28420	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IT782_RS28465	COG0745	RESPONSE REGULATOR receiver
IT782_RS28470	COG0243	molybdopterin cofactor binding
IT782_RS28475	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IT782_RS28480	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IT782_RS28480	COG2146	nitrite reductase [NAD(P)H] activity
IT782_RS28530	COG2188	Transcriptional regulator
IT782_RS28535	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IT782_RS28540	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IT782_RS28545	COG1984	allophanate hydrolase subunit 2
IT782_RS28565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT782_RS28575	COG1120	ATPase activity
IT782_RS28600	COG1132	(ABC) transporter
IT782_RS28605	COG1132	(ABC) transporter
IT782_RS28610	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IT782_RS28620	COG0110	maltose O-acetyltransferase activity
IT782_RS28640	COG0494	nUDIX hydrolase
IT782_RS28665	COG0235	Class ii aldolase
IT782_RS28685	COG1116	anion transmembrane transporter activity
IT782_RS28695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IT782_RS28705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IT782_RS28710	COG0583	DNA-binding transcription factor activity
IT782_RS28720	COG1028	Short-chain dehydrogenase reductase Sdr
IT782_RS28735	COG2124	cytochrome p450
IT782_RS28740	COG1174	glycine betaine transport
IT782_RS28745	COG1174	glycine betaine transport
IT782_RS28755	COG1125	glycine betaine transport
IT782_RS28755	COG0517	IMP dehydrogenase activity
IT782_RS28780	COG1960	acyl-CoA dehydrogenase activity
IT782_RS28785	COG1960	acyl-CoA dehydrogenase activity
IT782_RS28795	COG0601	transmembrane transport
IT782_RS28800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT782_RS28805	COG0444	Belongs to the ABC transporter superfamily
IT782_RS28810	COG1124	(ABC) transporter
IT782_RS28825	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
IT782_RS28830	COG2318	DinB family
IT782_RS28890	COG1028	Short-chain dehydrogenase reductase Sdr
IT782_RS28955	COG0604	alcohol dehydrogenase
IT782_RS28955	COG3321	synthase
IT782_RS28970	COG0604	alcohol dehydrogenase
IT782_RS28970	COG3321	synthase
IT782_RS28990	COG2124	cytochrome p450
IT782_RS28995	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IT782_RS29030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IT782_RS29040	COG1129	ABC transporter
IT782_RS29070	COG3483	tryptophan 2,3-dioxygenase activity
IT782_RS29075	COG1028	Short-chain dehydrogenase reductase Sdr
IT782_RS29080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IT782_RS29085	COG2151	metal-sulfur cluster biosynthetic enzyme
IT782_RS29090	COG3396	Phenylacetate-CoA oxygenase
IT782_RS29100	COG3396	Phenylacetate-CoA oxygenase
IT782_RS29115	COG0604	alcohol dehydrogenase
IT782_RS29170	COG0515	serine threonine protein kinase
IT782_RS29205	COG1404	Belongs to the peptidase S8 family
IT782_RS29245	COG3321	synthase
IT782_RS29245	COG0300	oxidoreductase activity
IT782_RS29245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IT782_RS29245	COG4221	oxidoreductase activity
IT782_RS29255	COG4335	DNA alkylation repair
IT782_RS29280	COG0477	Major facilitator Superfamily
IT782_RS29305	COG1309	transcriptional regulator
IT782_RS29310	COG3246	L-lysine catabolic process to acetate
IT782_RS29315	COG1250	3-hydroxyacyl-CoA dehydrogenase
IT782_RS29340	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IT782_RS29350	COG1396	sequence-specific DNA binding
IT782_RS29360	COG2318	DinB family
IT782_RS29365	COG3547	Transposase (IS116 IS110 IS902 family)
IT782_RS29400	COG1175	transmembrane transport