locus-tag	class	description
SMD11_RS00030	COG2814	Major facilitator Superfamily
SMD11_RS00035	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS00085	COG3903	Transcriptional regulator
SMD11_RS00085	COG3629	intracellular signal transduction
SMD11_RS00235	COG2945	thiolester hydrolase activity
SMD11_RS00235	COG0596	Alpha beta hydrolase
SMD11_RS00240	COG1309	transcriptional regulator
SMD11_RS00245	COG2957	Belongs to the agmatine deiminase family
SMD11_RS00325	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SMD11_RS00335	COG0515	serine threonine protein kinase
SMD11_RS00340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMD11_RS00350	COG2124	cytochrome p450
SMD11_RS00360	COG1695	Transcriptional regulator
SMD11_RS00375	COG1309	transcriptional regulator
SMD11_RS00405	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SMD11_RS00410	COG0640	Transcriptional regulator
SMD11_RS00430	COG2208	phosphoserine phosphatase activity
SMD11_RS00430	COG1366	Belongs to the anti-sigma-factor antagonist family
SMD11_RS00430	COG2172	sigma factor antagonist activity
SMD11_RS00445	COG0590	tRNA wobble adenosine to inosine editing
SMD11_RS00460	COG0583	DNA-binding transcription factor activity
SMD11_RS00485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMD11_RS00505	COG1132	(ABC) transporter
SMD11_RS00585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMD11_RS00595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMD11_RS00660	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SMD11_RS00670	COG1960	acyl-CoA dehydrogenase activity
SMD11_RS00685	COG0477	Major facilitator Superfamily
SMD11_RS00735	COG0640	Transcriptional regulator
SMD11_RS00760	COG2226	methyltransferase
SMD11_RS00785	COG0019	diaminopimelate decarboxylase activity
SMD11_RS00825	COG0326	Molecular chaperone. Has ATPase activity
SMD11_RS00870	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS00880	COG0494	nUDIX hydrolase
SMD11_RS00895	COG3655	Transcriptional regulator
SMD11_RS00925	COG0318	PFAM AMP-dependent synthetase and ligase
SMD11_RS00930	COG4221	oxidoreductase activity
SMD11_RS00940	COG0583	DNA-binding transcription factor activity
SMD11_RS00945	COG0768	penicillin binding
SMD11_RS00965	COG2815	serine threonine protein kinase
SMD11_RS00965	COG0515	serine threonine protein kinase
SMD11_RS01000	COG2264	protein methyltransferase activity
SMD11_RS01005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMD11_RS01020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMD11_RS01030	COG2318	DinB family
SMD11_RS01045	COG2197	response regulator
SMD11_RS01050	COG4585	Histidine kinase
SMD11_RS01060	COG2197	response regulator
SMD11_RS01070	COG1595	DNA-templated transcription, initiation
SMD11_RS01090	COG0477	Major facilitator Superfamily
SMD11_RS01125	COG2304	oxidoreductase activity
SMD11_RS01130	COG0438	transferase activity, transferring glycosyl groups
SMD11_RS01135	COG0745	RESPONSE REGULATOR receiver
SMD11_RS01140	COG5002	protein histidine kinase activity
SMD11_RS01145	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS01155	COG0148	phosphopyruvate hydratase activity
SMD11_RS01180	COG0318	PFAM AMP-dependent synthetase and ligase
SMD11_RS01185	COG0204	Acyl-transferase
SMD11_RS01190	COG2364	Membrane
SMD11_RS01195	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SMD11_RS01200	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SMD11_RS01230	COG3540	Alkaline phosphatase
SMD11_RS01260	COG0488	(ABC) transporter
SMD11_RS01270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SMD11_RS01275	COG1120	ATPase activity
SMD11_RS01280	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD11_RS01285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD11_RS01295	COG0477	Major facilitator Superfamily
SMD11_RS01305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMD11_RS01320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMD11_RS01340	COG0488	(ABC) transporter
SMD11_RS01350	COG2207	Transcriptional regulator
SMD11_RS01430	COG1960	acyl-CoA dehydrogenase activity
SMD11_RS01470	COG0477	Major facilitator Superfamily
SMD11_RS01505	COG3903	Transcriptional regulator
SMD11_RS01505	COG3629	intracellular signal transduction
SMD11_RS01515	COG3973	AAA domain
SMD11_RS01550	COG0189	ligase activity
SMD11_RS01590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SMD11_RS01595	COG0640	Transcriptional regulator
SMD11_RS01600	COG0798	PFAM Bile acid sodium symporter
SMD11_RS01650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMD11_RS01705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMD11_RS01770	COG2207	Transcriptional regulator
SMD11_RS01770	COG3708	Transcriptional regulator
SMD11_RS01775	COG0668	transmembrane transport
SMD11_RS01800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMD11_RS01825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD11_RS01855	COG0736	holo-[acyl-carrier-protein] synthase activity
SMD11_RS01860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMD11_RS01865	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SMD11_RS01870	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMD11_RS01890	COG1228	amidohydrolase
SMD11_RS01905	COG0736	holo-[acyl-carrier-protein] synthase activity
SMD11_RS01920	COG2814	Major facilitator Superfamily
SMD11_RS01925	COG0640	Transcriptional regulator
SMD11_RS01970	COG2409	Drug exporters of the RND superfamily
SMD11_RS01975	COG0723	plastoquinol--plastocyanin reductase activity
SMD11_RS01975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMD11_RS01980	COG1902	pentaerythritol trinitrate reductase activity
SMD11_RS01985	COG0789	Transcriptional regulator
SMD11_RS01995	COG2353	YceI-like domain
SMD11_RS02000	COG4249	Peptidase C14 caspase catalytic subunit p20
SMD11_RS02000	COG2319	Wd-40 repeat
SMD11_RS02015	COG2272	Belongs to the type-B carboxylesterase lipase family
SMD11_RS02025	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SMD11_RS02055	COG2746	aminoglycoside 3-N-acetyltransferase activity
SMD11_RS02090	COG1012	belongs to the aldehyde dehydrogenase family
SMD11_RS02110	COG1162	GTPase activity
SMD11_RS02145	COG0477	Major facilitator Superfamily
SMD11_RS02215	COG1222	aaa ATPase
SMD11_RS02250	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS02295	COG0328	RNA-DNA hybrid ribonuclease activity
SMD11_RS02305	COG2072	flavoprotein involved in K transport
SMD11_RS02320	COG2267	carboxylic ester hydrolase activity
SMD11_RS02355	COG4941	Belongs to the sigma-70 factor family
SMD11_RS02365	COG1522	sequence-specific DNA binding
SMD11_RS02375	COG1687	branched-chain amino acid
SMD11_RS02395	COG1609	Transcriptional regulator
SMD11_RS02440	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SMD11_RS02445	COG1132	(ABC) transporter
SMD11_RS02465	COG3629	intracellular signal transduction
SMD11_RS02465	COG3903	Transcriptional regulator
SMD11_RS02485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMD11_RS02505	COG1012	belongs to the aldehyde dehydrogenase family
SMD11_RS02525	COG3903	Transcriptional regulator
SMD11_RS02525	COG3629	intracellular signal transduction
SMD11_RS02650	COG1802	Transcriptional regulator
SMD11_RS02660	COG3938	Belongs to the proline racemase family
SMD11_RS02680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMD11_RS02685	COG0006	proline dipeptidase activity
SMD11_RS02695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMD11_RS02700	COG0601	transmembrane transport
SMD11_RS02710	COG4608	Belongs to the ABC transporter superfamily
SMD11_RS02745	COG2201	protein-glutamate methylesterase activity
SMD11_RS02750	COG2814	Major facilitator Superfamily
SMD11_RS02840	COG2376	Dihydroxyacetone kinase
SMD11_RS02865	COG3237	CsbD-like
SMD11_RS02885	COG0586	Pfam SNARE associated Golgi protein
SMD11_RS02890	COG2124	cytochrome p450
SMD11_RS02910	COG1215	transferase activity, transferring glycosyl groups
SMD11_RS02925	COG0515	serine threonine protein kinase
SMD11_RS02975	COG1802	Transcriptional regulator
SMD11_RS02985	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SMD11_RS02995	COG0477	Major facilitator Superfamily
SMD11_RS03010	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SMD11_RS03015	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SMD11_RS03020	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMD11_RS03040	COG1902	pentaerythritol trinitrate reductase activity
SMD11_RS03065	COG2084	Dehydrogenase
SMD11_RS03075	COG3903	Transcriptional regulator
SMD11_RS03075	COG3629	intracellular signal transduction
SMD11_RS03095	COG1215	transferase activity, transferring glycosyl groups
SMD11_RS03100	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SMD11_RS03110	COG0633	Ferredoxin
SMD11_RS03110	COG3217	Mosc domain protein beta barrel domain protein
SMD11_RS03130	COG1349	DNA-binding transcription factor activity
SMD11_RS03160	COG1940	carbohydrate kinase activity
SMD11_RS03165	COG2223	nitrite transmembrane transporter activity
SMD11_RS03175	COG2197	response regulator
SMD11_RS03180	COG4585	Histidine kinase
SMD11_RS03185	COG0445	tRNA wobble uridine modification
SMD11_RS03195	COG1660	Displays ATPase and GTPase activities
SMD11_RS03215	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SMD11_RS03255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMD11_RS03260	COG0765	amino acid transport
SMD11_RS03295	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS03305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMD11_RS03310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMD11_RS03320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SMD11_RS03330	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SMD11_RS03355	COG0604	alcohol dehydrogenase
SMD11_RS03370	COG0655	NAD(P)H dehydrogenase (quinone) activity
SMD11_RS03385	COG3629	intracellular signal transduction
SMD11_RS03400	COG0671	phosphoesterase, PA-phosphatase related
SMD11_RS03435	COG2124	cytochrome p450
SMD11_RS03445	COG0076	glutamate decarboxylase activity
SMD11_RS03470	COG0640	Transcriptional regulator
SMD11_RS03475	COG1902	pentaerythritol trinitrate reductase activity
SMD11_RS03480	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SMD11_RS03495	COG2706	6-phosphogluconolactonase activity
SMD11_RS03505	COG1522	sequence-specific DNA binding
SMD11_RS03525	COG2072	flavoprotein involved in K transport
SMD11_RS03530	COG0247	lactate metabolic process
SMD11_RS03535	COG1139	Iron-sulfur cluster binding protein
SMD11_RS03540	COG1556	Lactate utilization protein
SMD11_RS03555	COG0477	Major facilitator Superfamily
SMD11_RS03565	COG1132	(ABC) transporter
SMD11_RS03585	COG1132	(ABC) transporter
SMD11_RS03600	COG1946	Acyl-CoA thioesterase
SMD11_RS03610	COG2018	Roadblock/LC7 domain
SMD11_RS03615	COG2226	methyltransferase
SMD11_RS03635	COG3511	phospholipase C
SMD11_RS03650	COG3239	Fatty acid desaturase
SMD11_RS03655	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SMD11_RS03665	COG2353	YceI-like domain
SMD11_RS03685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMD11_RS03690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMD11_RS03700	COG0531	amino acid
SMD11_RS03705	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SMD11_RS03705	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SMD11_RS03715	COG1960	acyl-CoA dehydrogenase activity
SMD11_RS03720	COG1960	acyl-CoA dehydrogenase activity
SMD11_RS03740	COG1175	transmembrane transport
SMD11_RS03745	COG0395	ABC-type sugar transport system, permease component
SMD11_RS03765	COG5479	isomerase activity
SMD11_RS03765	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SMD11_RS03800	COG1024	Enoyl-CoA hydratase
SMD11_RS03810	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS03825	COG4221	oxidoreductase activity
SMD11_RS03830	COG0183	Belongs to the thiolase family
SMD11_RS03835	COG1309	transcriptional regulator
SMD11_RS03845	COG1024	Enoyl-CoA hydratase
SMD11_RS03850	COG1960	acyl-CoA dehydrogenase activity
SMD11_RS03855	COG1960	acyl-CoA dehydrogenase activity
SMD11_RS03865	COG1846	Transcriptional regulator
SMD11_RS03880	COG2205	protein histidine kinase activity
SMD11_RS03885	COG0745	RESPONSE REGULATOR receiver
SMD11_RS03910	COG1960	acyl-CoA dehydrogenase activity
SMD11_RS03915	COG1024	Enoyl-CoA hydratase
SMD11_RS03935	COG3572	ergothioneine biosynthetic process
SMD11_RS03940	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SMD11_RS03945	COG0121	glutamine amidotransferase
SMD11_RS03950	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SMD11_RS03970	COG3360	Dodecin
SMD11_RS03985	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SMD11_RS03990	COG0531	amino acid
SMD11_RS03995	COG3537	Alpha-1,2-mannosidase
SMD11_RS04030	COG0747	negative chemotaxis
SMD11_RS04065	COG0596	Alpha beta hydrolase
SMD11_RS04070	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SMD11_RS04095	COG2264	protein methyltransferase activity
SMD11_RS04110	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SMD11_RS04120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMD11_RS04150	COG0477	Major facilitator Superfamily
SMD11_RS04180	COG0778	Nitroreductase
SMD11_RS04185	COG1846	Transcriptional regulator
SMD11_RS04190	COG0189	ligase activity
SMD11_RS04200	COG0745	RESPONSE REGULATOR receiver
SMD11_RS04205	COG5002	protein histidine kinase activity
SMD11_RS04215	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
SMD11_RS04225	COG0531	amino acid
SMD11_RS04270	COG3903	Transcriptional regulator
SMD11_RS04270	COG3629	intracellular signal transduction
SMD11_RS04295	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS04325	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SMD11_RS04360	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SMD11_RS04365	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SMD11_RS04370	COG0702	epimerase
SMD11_RS04390	COG1191	sigma factor activity
SMD11_RS04395	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SMD11_RS04400	COG1609	Transcriptional regulator
SMD11_RS04405	COG1129	ABC transporter
SMD11_RS04410	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMD11_RS04415	COG1879	ABC-type sugar transport system periplasmic component
SMD11_RS04420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMD11_RS04445	COG1132	(ABC) transporter
SMD11_RS04485	COG0477	Major facilitator Superfamily
SMD11_RS04490	COG2197	response regulator
SMD11_RS04515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD11_RS04520	COG2382	esterase
SMD11_RS04525	COG0477	Major facilitator Superfamily
SMD11_RS04535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD11_RS04545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SMD11_RS04550	COG1120	ATPase activity
SMD11_RS04590	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SMD11_RS04595	COG0477	Major facilitator Superfamily
SMD11_RS04600	COG2124	cytochrome p450
SMD11_RS04605	COG1773	rubredoxin
SMD11_RS04610	COG2267	carboxylic ester hydrolase activity
SMD11_RS04635	COG0318	PFAM AMP-dependent synthetase and ligase
SMD11_RS04645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMD11_RS04660	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SMD11_RS04665	COG2011	ABC-type metal ion transport system permease component
SMD11_RS04690	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SMD11_RS04720	COG2255	four-way junction helicase activity
SMD11_RS04740	COG2860	membrane
SMD11_RS04770	COG0534	Mate efflux family protein
SMD11_RS04775	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SMD11_RS04780	COG0019	diaminopimelate decarboxylase activity
SMD11_RS04795	COG4166	transmembrane transport
SMD11_RS04800	COG0601	transmembrane transport
SMD11_RS04805	COG4171	peptide transport system, permease
SMD11_RS04820	COG2124	cytochrome p450
SMD11_RS04855	COG0515	serine threonine protein kinase
SMD11_RS04865	COG2197	response regulator
SMD11_RS04870	COG4585	Histidine kinase
SMD11_RS04905	COG0585	pseudouridine synthase activity
SMD11_RS04910	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SMD11_RS04920	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SMD11_RS04930	COG1960	acyl-CoA dehydrogenase activity
SMD11_RS04995	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SMD11_RS05000	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SMD11_RS05005	COG0569	domain protein
SMD11_RS05020	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SMD11_RS05060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMD11_RS05060	COG0045	succinate-CoA ligase (ADP-forming) activity
SMD11_RS05060	COG1042	CoA-binding domain protein
SMD11_RS05095	COG0309	Hydrogenase expression formation protein (HypE)
SMD11_RS05115	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SMD11_RS05120	COG2217	Heavy metal translocating P-type atpase
SMD11_RS05135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SMD11_RS05135	COG0574	Belongs to the PEP-utilizing enzyme family
SMD11_RS05150	COG0517	IMP dehydrogenase activity
SMD11_RS05150	COG0516	GMP reductase activity
SMD11_RS05165	COG0517	IMP dehydrogenase activity
SMD11_RS05225	COG4974	Belongs to the 'phage' integrase family
SMD11_RS05245	COG1228	amidohydrolase
SMD11_RS05265	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMD11_RS05290	COG2755	lipolytic protein G-D-S-L family
SMD11_RS05305	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SMD11_RS05310	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SMD11_RS05325	COG1657	PFAM Prenyltransferase squalene oxidase
SMD11_RS05335	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SMD11_RS05345	COG1562	ergosterol biosynthetic process
SMD11_RS05350	COG1134	teichoic acid transport
SMD11_RS05350	COG1388	LysM domain
SMD11_RS05385	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SMD11_RS05395	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SMD11_RS05410	COG1024	Enoyl-CoA hydratase
SMD11_RS05425	COG4977	sequence-specific DNA binding
SMD11_RS05445	COG2183	response to ionizing radiation
SMD11_RS05450	COG0488	(ABC) transporter
SMD11_RS05455	COG2936	dipeptidyl-peptidase activity
SMD11_RS05470	COG0789	Transcriptional regulator
SMD11_RS05475	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMD11_RS05475	COG1024	Enoyl-CoA hydratase
SMD11_RS05480	COG0183	Belongs to the thiolase family
SMD11_RS05485	COG1960	acyl-CoA dehydrogenase activity
SMD11_RS05490	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SMD11_RS05500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMD11_RS05510	COG1515	deoxyribonuclease V activity
SMD11_RS05535	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SMD11_RS05550	COG4977	sequence-specific DNA binding
SMD11_RS05555	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMD11_RS05595	COG2814	Major facilitator Superfamily
SMD11_RS05600	COG1309	transcriptional regulator
SMD11_RS05610	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SMD11_RS05620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD11_RS05645	COG4585	Histidine kinase
SMD11_RS05650	COG2197	response regulator
SMD11_RS05750	COG1012	belongs to the aldehyde dehydrogenase family
SMD11_RS05755	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SMD11_RS05760	COG1846	Transcriptional regulator
SMD11_RS05780	COG0583	DNA-binding transcription factor activity
SMD11_RS05815	COG2154	pterin-4-alpha-carbinolamine dehydratase
SMD11_RS05835	COG0656	L-ascorbic acid biosynthetic process
SMD11_RS05840	COG1309	transcriptional regulator
SMD11_RS05845	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS05850	COG0531	amino acid
SMD11_RS05905	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMD11_RS05905	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMD11_RS05920	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SMD11_RS05930	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMD11_RS06275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD11_RS06280	COG0028	Belongs to the TPP enzyme family
SMD11_RS06285	COG0693	protein deglycase activity
SMD11_RS06330	COG1309	transcriptional regulator
SMD11_RS06335	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS06355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD11_RS06360	COG1535	isochorismatase
SMD11_RS06360	COG3433	isochorismatase activity
SMD11_RS06365	COG1535	isochorismatase
SMD11_RS06365	COG3433	isochorismatase activity
SMD11_RS06370	COG1021	2,3-dihydroxybenzoate-AMP ligase
SMD11_RS06375	COG1169	isochorismate synthase
SMD11_RS06380	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS06390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMD11_RS06395	COG2362	D-Aminopeptidase
SMD11_RS06435	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SMD11_RS06450	COG0477	Major facilitator Superfamily
SMD11_RS06480	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMD11_RS06495	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SMD11_RS06495	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SMD11_RS06500	COG2301	Belongs to the HpcH HpaI aldolase family
SMD11_RS06510	COG1960	acyl-CoA dehydrogenase activity
SMD11_RS06515	COG0688	phosphatidylethanolamine metabolic process
SMD11_RS06525	COG1929	Belongs to the glycerate kinase type-1 family
SMD11_RS06530	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SMD11_RS06540	COG1309	transcriptional regulator
SMD11_RS06545	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SMD11_RS06560	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMD11_RS06595	COG0483	inositol monophosphate 1-phosphatase activity
SMD11_RS06610	COG0095	Lipoate-protein ligase
SMD11_RS06625	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SMD11_RS06630	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMD11_RS06650	COG1335	isochorismatase
SMD11_RS06660	COG0405	Gamma-glutamyltransferase
SMD11_RS06665	COG2755	lipolytic protein G-D-S-L family
SMD11_RS06675	COG1959	2 iron, 2 sulfur cluster binding
SMD11_RS06680	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SMD11_RS06680	COG1017	nitric oxide dioxygenase activity
SMD11_RS06715	COG0667	Aldo Keto reductase
SMD11_RS06720	COG0765	amino acid transport
SMD11_RS06725	COG0765	amino acid transport
SMD11_RS06730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMD11_RS06735	COG1126	abc transporter atp-binding protein
SMD11_RS06760	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SMD11_RS06765	COG2267	carboxylic ester hydrolase activity
SMD11_RS06770	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SMD11_RS06795	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMD11_RS06820	COG3903	Transcriptional regulator
SMD11_RS06820	COG3629	intracellular signal transduction
SMD11_RS06825	COG3903	Transcriptional regulator
SMD11_RS06825	COG3629	intracellular signal transduction
SMD11_RS06835	COG1940	carbohydrate kinase activity
SMD11_RS06850	COG1879	ABC-type sugar transport system periplasmic component
SMD11_RS06855	COG2188	Transcriptional regulator
SMD11_RS06900	COG4266	Belongs to the allantoicase family
SMD11_RS06905	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SMD11_RS06910	COG1414	Transcriptional regulator
SMD11_RS06925	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SMD11_RS06935	COG2233	PERMEase
SMD11_RS06950	COG2351	hydroxyisourate hydrolase activity
SMD11_RS06970	COG0640	Transcriptional regulator
SMD11_RS06975	COG3622	Belongs to the hyi family
SMD11_RS06980	COG2084	Dehydrogenase
SMD11_RS06985	COG3960	tartronate-semialdehyde synthase activity
SMD11_RS06995	COG0318	PFAM AMP-dependent synthetase and ligase
SMD11_RS07000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMD11_RS07005	COG2197	response regulator
SMD11_RS07025	COG0598	Magnesium transport protein CorA
SMD11_RS07035	COG2274	protein secretion by the type I secretion system
SMD11_RS07055	COG1285	pathogenesis
SMD11_RS07095	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMD11_RS07100	COG2252	PERMEase
SMD11_RS07125	COG1802	Transcriptional regulator
SMD11_RS07160	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMD11_RS07170	COG1162	GTPase activity
SMD11_RS07185	COG0456	acetyltransferase
SMD11_RS07200	COG0175	sulfate reduction
SMD11_RS07205	COG0529	Catalyzes the synthesis of activated sulfate
SMD11_RS07225	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
SMD11_RS07230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SMD11_RS07240	COG1280	lysine exporter protein (LysE YggA)
SMD11_RS07295	COG0583	DNA-binding transcription factor activity
SMD11_RS07300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SMD11_RS07315	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMD11_RS07320	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SMD11_RS07325	COG2197	response regulator
SMD11_RS07330	COG4585	Histidine kinase
SMD11_RS07335	COG0577	efflux transmembrane transporter activity
SMD11_RS07370	COG4152	abc transporter atp-binding protein
SMD11_RS07385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMD11_RS07400	COG0446	pyridine nucleotide-disulphide oxidoreductase
SMD11_RS07410	COG3485	protocatechuate 3,4-dioxygenase
SMD11_RS07415	COG3485	protocatechuate 3,4-dioxygenase
SMD11_RS07425	COG1414	Transcriptional regulator
SMD11_RS07430	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SMD11_RS07435	COG3253	May function as heme-dependent peroxidase
SMD11_RS07450	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SMD11_RS07470	COG0183	Belongs to the thiolase family
SMD11_RS07475	COG1024	Enoyl-CoA hydratase
SMD11_RS07475	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMD11_RS07490	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SMD11_RS07520	COG0531	amino acid
SMD11_RS07525	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SMD11_RS07530	COG4214	carbohydrate transport
SMD11_RS07540	COG4213	ABC transporter substrate-binding protein
SMD11_RS07570	COG0395	ABC-type sugar transport system, permease component
SMD11_RS07575	COG1175	transmembrane transport
SMD11_RS07580	COG1653	transport
SMD11_RS07595	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SMD11_RS07600	COG2267	carboxylic ester hydrolase activity
SMD11_RS07610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMD11_RS07620	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SMD11_RS07625	COG4974	Belongs to the 'phage' integrase family
SMD11_RS07720	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SMD11_RS07740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMD11_RS07745	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMD11_RS07750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMD11_RS07755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SMD11_RS07760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMD11_RS07765	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SMD11_RS07770	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS07775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMD11_RS07780	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SMD11_RS07785	COG3629	intracellular signal transduction
SMD11_RS07785	COG3903	Transcriptional regulator
SMD11_RS07810	COG0667	Aldo Keto reductase
SMD11_RS07820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SMD11_RS07855	COG2264	protein methyltransferase activity
SMD11_RS07870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMD11_RS07910	COG1960	acyl-CoA dehydrogenase activity
SMD11_RS07930	COG1024	Enoyl-CoA hydratase
SMD11_RS07935	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SMD11_RS07940	COG2235	arginine
SMD11_RS07945	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SMD11_RS07955	COG2040	homocysteine
SMD11_RS07985	COG1799	cell septum assembly
SMD11_RS08000	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SMD11_RS08005	COG0488	(ABC) transporter
SMD11_RS08020	COG1819	glycosyl
SMD11_RS08025	COG2124	cytochrome p450
SMD11_RS08030	COG2226	methyltransferase
SMD11_RS08070	COG2124	cytochrome p450
SMD11_RS08120	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SMD11_RS08130	COG1819	glycosyl
SMD11_RS08135	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMD11_RS08160	COG0667	Aldo Keto reductase
SMD11_RS08195	COG0529	Catalyzes the synthesis of activated sulfate
SMD11_RS08195	COG2895	sulfate adenylyltransferase (ATP) activity
SMD11_RS08200	COG0175	sulfate reduction
SMD11_RS08220	COG0604	alcohol dehydrogenase
SMD11_RS08220	COG3321	synthase
SMD11_RS08225	COG0019	diaminopimelate decarboxylase activity
SMD11_RS08230	COG0318	PFAM AMP-dependent synthetase and ligase
SMD11_RS08250	COG2267	carboxylic ester hydrolase activity
SMD11_RS08255	COG0604	alcohol dehydrogenase
SMD11_RS08255	COG3321	synthase
SMD11_RS08265	COG3321	synthase
SMD11_RS08265	COG0604	alcohol dehydrogenase
SMD11_RS08290	COG2197	response regulator
SMD11_RS08295	COG4585	Histidine kinase
SMD11_RS08305	COG1131	(ABC) transporter
SMD11_RS08325	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SMD11_RS08330	COG0531	amino acid
SMD11_RS08380	COG3629	intracellular signal transduction
SMD11_RS08390	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SMD11_RS08400	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SMD11_RS08405	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SMD11_RS08410	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SMD11_RS08435	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SMD11_RS08445	COG2264	protein methyltransferase activity
SMD11_RS08460	COG0569	domain protein
SMD11_RS08500	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SMD11_RS08505	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SMD11_RS08510	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SMD11_RS08525	COG0756	dUTP diphosphatase activity
SMD11_RS08550	COG2205	protein histidine kinase activity
SMD11_RS08555	COG0745	RESPONSE REGULATOR receiver
SMD11_RS08565	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SMD11_RS08600	COG1435	thymidine kinase activity
SMD11_RS08615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMD11_RS08615	COG1042	CoA-binding domain protein
SMD11_RS08615	COG0045	succinate-CoA ligase (ADP-forming) activity
SMD11_RS08620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMD11_RS08625	COG1802	Transcriptional regulator
SMD11_RS08640	COG0612	Peptidase, M16
SMD11_RS08645	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SMD11_RS08655	COG0372	Belongs to the citrate synthase family
SMD11_RS08675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SMD11_RS08685	COG3290	protein histidine kinase activity
SMD11_RS08690	COG4565	transcriptional regulatory protein
SMD11_RS08695	COG0187	DNA topoisomerase II activity
SMD11_RS08710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SMD11_RS08720	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SMD11_RS08755	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SMD11_RS08765	COG0588	phosphoglycerate mutase activity
SMD11_RS08770	COG0488	(ABC) transporter
SMD11_RS08805	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMD11_RS08810	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SMD11_RS08815	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SMD11_RS08845	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SMD11_RS08855	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SMD11_RS08855	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SMD11_RS08860	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SMD11_RS08870	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SMD11_RS08890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SMD11_RS08900	COG2205	protein histidine kinase activity
SMD11_RS08905	COG0745	RESPONSE REGULATOR receiver
SMD11_RS08910	COG1126	abc transporter atp-binding protein
SMD11_RS08915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMD11_RS08920	COG0765	amino acid transport
SMD11_RS08925	COG0765	amino acid transport
SMD11_RS08930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMD11_RS08950	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SMD11_RS08970	COG1201	RNA secondary structure unwinding
SMD11_RS08975	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SMD11_RS08990	COG1396	sequence-specific DNA binding
SMD11_RS08995	COG1546	Belongs to the CinA family
SMD11_RS08995	COG1058	Belongs to the CinA family
SMD11_RS09005	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SMD11_RS09015	COG1674	ftsk spoiiie
SMD11_RS09025	COG2205	protein histidine kinase activity
SMD11_RS09025	COG4999	Histidine kinase
SMD11_RS09025	COG3850	Histidine kinase
SMD11_RS09025	COG3437	response regulator, receiver
SMD11_RS09030	COG2208	phosphoserine phosphatase activity
SMD11_RS09030	COG2770	Histidine kinase
SMD11_RS09065	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SMD11_RS09070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMD11_RS09075	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SMD11_RS09095	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SMD11_RS09105	COG1185	polyribonucleotide nucleotidyltransferase activity
SMD11_RS09110	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SMD11_RS09120	COG1674	ftsk spoiiie
SMD11_RS09190	COG1404	Belongs to the peptidase S8 family
SMD11_RS09210	COG0455	bacterial-type flagellum organization
SMD11_RS09225	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SMD11_RS09230	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SMD11_RS09240	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SMD11_RS09255	COG0779	Required for maturation of 30S ribosomal subunits
SMD11_RS09275	COG0442	prolyl-tRNA aminoacylation
SMD11_RS09290	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SMD11_RS09295	COG0750	zinc metalloprotease
SMD11_RS09300	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SMD11_RS09320	COG2508	Transcriptional regulator
SMD11_RS09320	COG2508	Transcriptional regulator
SMD11_RS09345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMD11_RS09350	COG1177	transmembrane transport
SMD11_RS09355	COG1176	ABC-type spermidine putrescine transport system, permease component I
SMD11_RS09360	COG3842	ATPase activity
SMD11_RS09385	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SMD11_RS09405	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SMD11_RS09410	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SMD11_RS09410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMD11_RS09415	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMD11_RS09415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMD11_RS09435	COG0477	Major facilitator Superfamily
SMD11_RS09445	COG1012	belongs to the aldehyde dehydrogenase family
SMD11_RS09455	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SMD11_RS09460	COG1136	(ABC) transporter
SMD11_RS09480	COG3842	ATPase activity
SMD11_RS09495	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SMD11_RS09505	COG0233	cytoplasmic translational termination
SMD11_RS09510	COG0528	UMP kinase activity
SMD11_RS09515	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SMD11_RS09520	COG0052	Belongs to the universal ribosomal protein uS2 family
SMD11_RS09535	COG1191	sigma factor activity
SMD11_RS09550	COG0792	nuclease activity
SMD11_RS09565	COG0681	Belongs to the peptidase S26 family
SMD11_RS09570	COG0681	Belongs to the peptidase S26 family
SMD11_RS09575	COG0681	Belongs to the peptidase S26 family
SMD11_RS09585	COG0335	large ribosomal subunit rRNA binding
SMD11_RS09590	COG0336	Belongs to the RNA methyltransferase TrmD family
SMD11_RS09595	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SMD11_RS09600	COG1837	Belongs to the UPF0109 family
SMD11_RS09605	COG0228	four-way junction DNA binding
SMD11_RS09615	COG0442	prolyl-tRNA aminoacylation
SMD11_RS09630	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SMD11_RS09660	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
SMD11_RS09665	COG0477	Major facilitator Superfamily
SMD11_RS09680	COG1254	Belongs to the acylphosphatase family
SMD11_RS09690	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SMD11_RS09695	COG0571	ribonuclease III activity
SMD11_RS09700	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SMD11_RS09715	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SMD11_RS09720	COG0742	ribosomal rna small subunit methyltransferase
SMD11_RS09740	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SMD11_RS09745	COG0351	phosphomethylpyrimidine kinase
SMD11_RS09765	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMD11_RS09770	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SMD11_RS09780	COG1920	GTP binding
SMD11_RS09790	COG0776	regulation of translation
SMD11_RS09800	COG0066	3-isopropylmalate dehydratase activity
SMD11_RS09805	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SMD11_RS09810	COG1414	Transcriptional regulator
SMD11_RS09860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMD11_RS09865	COG0179	Fumarylacetoacetate (FAA) hydrolase
SMD11_RS09875	COG5002	protein histidine kinase activity
SMD11_RS09880	COG2018	Roadblock/LC7 domain
SMD11_RS09900	COG2018	Roadblock/LC7 domain
SMD11_RS09920	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SMD11_RS09925	COG5492	domain, Protein
SMD11_RS09930	COG2353	YceI-like domain
SMD11_RS09945	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMD11_RS09950	COG0477	Major facilitator Superfamily
SMD11_RS09955	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SMD11_RS09960	COG0473	3-isopropylmalate dehydrogenase activity
SMD11_RS09995	COG1012	belongs to the aldehyde dehydrogenase family
SMD11_RS10000	COG0506	proline dehydrogenase activity
SMD11_RS10005	COG3835	regulator
SMD11_RS10020	COG2124	cytochrome p450
SMD11_RS10030	COG1309	transcriptional regulator
SMD11_RS10040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD11_RS10055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMD11_RS10060	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SMD11_RS10065	COG0440	acetolactate synthase activity
SMD11_RS10085	COG0667	Aldo Keto reductase
SMD11_RS10090	COG2133	pyrroloquinoline quinone binding
SMD11_RS10095	COG2197	response regulator
SMD11_RS10100	COG2409	Drug exporters of the RND superfamily
SMD11_RS10120	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SMD11_RS10130	COG0154	amidase activity
SMD11_RS10135	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SMD11_RS10145	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SMD11_RS10155	COG4221	oxidoreductase activity
SMD11_RS10175	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SMD11_RS10215	COG0482	sulfurtransferase activity
SMD11_RS10225	COG2378	regulation of single-species biofilm formation
SMD11_RS10240	COG2860	membrane
SMD11_RS10245	COG4608	Belongs to the ABC transporter superfamily
SMD11_RS10250	COG0444	Belongs to the ABC transporter superfamily
SMD11_RS10260	COG4166	transmembrane transport
SMD11_RS10285	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SMD11_RS10290	COG0509	glycine decarboxylation via glycine cleavage system
SMD11_RS10295	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SMD11_RS10300	COG1760	l-serine dehydratase
SMD11_RS10355	COG1132	(ABC) transporter
SMD11_RS10360	COG1132	(ABC) transporter
SMD11_RS10375	COG0058	SHG alpha-glucan phosphorylase activity
SMD11_RS10385	COG0366	Alpha amylase catalytic
SMD11_RS10390	COG0366	Alpha amylase catalytic
SMD11_RS10400	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SMD11_RS10430	COG1301	dicarboxylic acid transport
SMD11_RS10435	COG3290	protein histidine kinase activity
SMD11_RS10440	COG4565	transcriptional regulatory protein
SMD11_RS10450	COG1175	transmembrane transport
SMD11_RS10470	COG0477	Major facilitator Superfamily
SMD11_RS10505	COG0395	ABC-type sugar transport system, permease component
SMD11_RS10515	COG0577	efflux transmembrane transporter activity
SMD11_RS10515	COG1136	(ABC) transporter
SMD11_RS10520	COG1136	(ABC) transporter
SMD11_RS10520	COG0577	efflux transmembrane transporter activity
SMD11_RS10525	COG2084	Dehydrogenase
SMD11_RS10530	COG2910	NAD(P)H-binding
SMD11_RS10555	COG0205	6-phosphofructokinase activity
SMD11_RS10560	COG0280	phosphate acetyltransferase
SMD11_RS10560	COG0857	belongs to the CobB CobQ family
SMD11_RS10565	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SMD11_RS10600	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SMD11_RS10600	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SMD11_RS10650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMD11_RS10670	COG0183	Belongs to the thiolase family
SMD11_RS10690	COG1131	(ABC) transporter
SMD11_RS10730	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
SMD11_RS10745	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMD11_RS10760	COG4585	Histidine kinase
SMD11_RS10765	COG2197	response regulator
SMD11_RS10780	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SMD11_RS10785	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SMD11_RS10790	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SMD11_RS10795	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SMD11_RS10800	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SMD11_RS10805	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SMD11_RS10810	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SMD11_RS10825	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMD11_RS10830	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SMD11_RS10835	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SMD11_RS10845	COG2890	protein-(glutamine-N5) methyltransferase activity
SMD11_RS10850	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SMD11_RS10855	COG0254	rRNA binding
SMD11_RS10870	COG0083	homoserine kinase activity
SMD11_RS10875	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SMD11_RS10880	COG0460	homoserine dehydrogenase
SMD11_RS10885	COG0019	diaminopimelate decarboxylase activity
SMD11_RS10890	COG0018	arginyl-trna synthetase
SMD11_RS10890	COG0018	arginyl-trna synthetase
SMD11_RS10895	COG0745	RESPONSE REGULATOR receiver
SMD11_RS10915	COG0726	polysaccharide deacetylase
SMD11_RS10940	COG3883	PFAM NLP P60 protein
SMD11_RS10940	COG0791	NLP P60 protein
SMD11_RS10985	COG3227	Zinc metalloprotease (Elastase)
SMD11_RS11000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SMD11_RS11010	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SMD11_RS11040	COG0745	RESPONSE REGULATOR receiver
SMD11_RS11045	COG2205	protein histidine kinase activity
SMD11_RS11050	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMD11_RS11050	COG0567	Dehydrogenase, E1 component
SMD11_RS11080	COG0604	alcohol dehydrogenase
SMD11_RS11090	COG0281	malic enzyme
SMD11_RS11095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMD11_RS11100	COG0765	amino acid transport
SMD11_RS11130	COG0583	DNA-binding transcription factor activity
SMD11_RS11145	COG1191	sigma factor activity
SMD11_RS11160	COG0640	Transcriptional regulator
SMD11_RS11175	COG1316	TRANSCRIPTIONal
SMD11_RS11180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SMD11_RS11190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMD11_RS11200	COG2066	Belongs to the glutaminase family
SMD11_RS11245	COG1597	lipid kinase activity
SMD11_RS11265	COG0363	glucosamine-6-phosphate deaminase activity
SMD11_RS11270	COG1472	Belongs to the glycosyl hydrolase 3 family
SMD11_RS11275	COG0395	ABC-type sugar transport system, permease component
SMD11_RS11280	COG1175	transmembrane transport
SMD11_RS11285	COG2182	Extracellular solute-binding protein
SMD11_RS11290	COG2188	Transcriptional regulator
SMD11_RS11355	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMD11_RS11370	COG0242	peptide deformylase activity
SMD11_RS11385	COG2199	diguanylate cyclase activity
SMD11_RS11385	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SMD11_RS11390	COG5662	AntiSigma factor
SMD11_RS11395	COG1595	DNA-templated transcription, initiation
SMD11_RS11405	COG2135	peptidase activity
SMD11_RS11415	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SMD11_RS11425	COG2076	Multidrug Resistance protein
SMD11_RS11455	COG0483	inositol monophosphate 1-phosphatase activity
SMD11_RS11465	COG0753	catalase activity
SMD11_RS11490	COG1615	UPF0182 protein
SMD11_RS11500	COG3480	Lon protease (S16) C-terminal proteolytic domain
SMD11_RS11555	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SMD11_RS11600	COG0210	DNA helicase
SMD11_RS11670	COG4172	Belongs to the ABC transporter superfamily
SMD11_RS11680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMD11_RS11725	COG0513	Belongs to the DEAD box helicase family
SMD11_RS11730	COG0596	Alpha beta hydrolase
SMD11_RS11740	COG1432	Conserved Protein
SMD11_RS11750	COG2095	MarC family integral membrane protein
SMD11_RS11770	COG0598	Magnesium transport protein CorA
SMD11_RS11805	COG3422	double-strand break repair
SMD11_RS11815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SMD11_RS11820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMD11_RS11830	COG1595	DNA-templated transcription, initiation
SMD11_RS11845	COG1024	Enoyl-CoA hydratase
SMD11_RS11850	COG0519	Catalyzes the synthesis of GMP from XMP
SMD11_RS11860	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SMD11_RS11870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMD11_RS11910	COG2197	response regulator
SMD11_RS11915	COG4585	Histidine kinase
SMD11_RS11925	COG1131	(ABC) transporter
SMD11_RS11945	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SMD11_RS11960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMD11_RS11965	COG0747	negative chemotaxis
SMD11_RS11980	COG4608	Belongs to the ABC transporter superfamily
SMD11_RS11985	COG4608	Belongs to the ABC transporter superfamily
SMD11_RS11995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMD11_RS12000	COG0601	transmembrane transport
SMD11_RS12005	COG4166	transmembrane transport
SMD11_RS12010	COG4608	Belongs to the ABC transporter superfamily
SMD11_RS12015	COG0444	Belongs to the ABC transporter superfamily
SMD11_RS12020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMD11_RS12025	COG0601	transmembrane transport
SMD11_RS12035	COG1217	gtp-binding protein TYPA
SMD11_RS12075	COG0531	amino acid
SMD11_RS12110	COG0012	GTP binding
SMD11_RS12125	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SMD11_RS12130	COG1113	amino acid transport
SMD11_RS12135	COG1570	exodeoxyribonuclease VII activity
SMD11_RS12140	COG1722	exodeoxyribonuclease VII activity
SMD11_RS12145	COG0778	Nitroreductase
SMD11_RS12170	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SMD11_RS12170	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SMD11_RS12180	COG0114	fumarate hydratase activity
SMD11_RS12205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMD11_RS12230	COG0450	alkyl hydroperoxide reductase
SMD11_RS12235	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMD11_RS12250	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SMD11_RS12255	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SMD11_RS12260	COG0667	Aldo Keto reductase
SMD11_RS12300	COG2885	chlorophyll binding
SMD11_RS12340	COG2894	cell division
SMD11_RS12375	COG0251	oxidation-reduction process
SMD11_RS12380	COG1414	Transcriptional regulator
SMD11_RS12395	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SMD11_RS12410	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
SMD11_RS12420	COG0477	Major facilitator Superfamily
SMD11_RS12430	COG1331	Highly conserved protein containing a thioredoxin domain
SMD11_RS12440	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SMD11_RS12450	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SMD11_RS12465	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SMD11_RS12495	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMD11_RS12510	COG0590	tRNA wobble adenosine to inosine editing
SMD11_RS12515	COG0740	serine-type endopeptidase activity
SMD11_RS12520	COG0740	serine-type endopeptidase activity
SMD11_RS12525	COG1396	sequence-specific DNA binding
SMD11_RS12535	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SMD11_RS12560	COG2986	histidine ammonia-lyase
SMD11_RS12570	COG1024	Enoyl-CoA hydratase
SMD11_RS12575	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SMD11_RS12585	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SMD11_RS12595	COG0768	penicillin binding
SMD11_RS12610	COG0659	secondary active sulfate transmembrane transporter activity
SMD11_RS12615	COG0424	maF-like protein
SMD11_RS12625	COG0693	protein deglycase activity
SMD11_RS12635	COG4770	biotin carboxylase activity
SMD11_RS12665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMD11_RS12680	COG1012	belongs to the aldehyde dehydrogenase family
SMD11_RS12685	COG1012	belongs to the aldehyde dehydrogenase family
SMD11_RS12700	COG1132	(ABC) transporter
SMD11_RS12700	COG2375	cellular response to nickel ion
SMD11_RS12705	COG1595	DNA-templated transcription, initiation
SMD11_RS12710	COG0745	RESPONSE REGULATOR receiver
SMD11_RS12715	COG2205	protein histidine kinase activity
SMD11_RS12740	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SMD11_RS12750	COG0583	DNA-binding transcription factor activity
SMD11_RS12755	COG2814	Major facilitator Superfamily
SMD11_RS12820	COG1079	Belongs to the binding-protein-dependent transport system permease family
SMD11_RS12825	COG4603	Belongs to the binding-protein-dependent transport system permease family
SMD11_RS12830	COG3845	ABC transporter
SMD11_RS12835	COG1744	ABC transporter substrate-binding protein PnrA-like
SMD11_RS12840	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SMD11_RS12840	COG1473	amidohydrolase
SMD11_RS12850	COG2089	acid synthase
SMD11_RS12865	COG1216	Glycosyl transferase, family 2
SMD11_RS12880	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SMD11_RS12900	COG3265	gluconokinase activity
SMD11_RS12905	COG2186	Transcriptional regulator
SMD11_RS12950	COG4977	sequence-specific DNA binding
SMD11_RS12965	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMD11_RS12965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMD11_RS13015	COG2197	response regulator
SMD11_RS13030	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SMD11_RS13030	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SMD11_RS13040	COG1595	DNA-templated transcription, initiation
SMD11_RS13060	COG2009	succinate dehydrogenase
SMD11_RS13075	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SMD11_RS13095	COG1686	Belongs to the peptidase S11 family
SMD11_RS13100	COG1295	ribonuclease BN
SMD11_RS13110	COG0180	Tryptophanyl-tRNA synthetase
SMD11_RS13115	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMD11_RS13120	COG0754	glutathionylspermidine amidase activity
SMD11_RS13135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMD11_RS13140	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMD11_RS13155	COG4176	ABC-type proline glycine betaine transport system permease component
SMD11_RS13160	COG4175	Glycine betaine
SMD11_RS13160	COG0517	IMP dehydrogenase activity
SMD11_RS13170	COG1012	belongs to the aldehyde dehydrogenase family
SMD11_RS13190	COG0039	L-malate dehydrogenase activity
SMD11_RS13200	COG0538	isocitrate dehydrogenase activity
SMD11_RS13210	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SMD11_RS13215	COG1714	RDD family
SMD11_RS13220	COG0138	bifunctional purine biosynthesis protein purh
SMD11_RS13245	COG0045	succinate-CoA ligase (ADP-forming) activity
SMD11_RS13260	COG0714	Associated with various cellular activities
SMD11_RS13275	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SMD11_RS13285	COG0739	heme binding
SMD11_RS13300	COG0791	NLP P60 protein
SMD11_RS13310	COG2197	response regulator
SMD11_RS13320	COG0515	serine threonine protein kinase
SMD11_RS13320	COG2815	serine threonine protein kinase
SMD11_RS13335	COG1376	ErfK ybiS ycfS ynhG family protein
SMD11_RS13350	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SMD11_RS13350	COG0519	Catalyzes the synthesis of GMP from XMP
SMD11_RS13370	COG1012	belongs to the aldehyde dehydrogenase family
SMD11_RS13380	COG2815	serine threonine protein kinase
SMD11_RS13380	COG0515	serine threonine protein kinase
SMD11_RS13385	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SMD11_RS13430	COG0346	lactoylglutathione lyase activity
SMD11_RS13520	COG2197	response regulator
SMD11_RS13525	COG4585	Histidine kinase
SMD11_RS13530	COG1366	Belongs to the anti-sigma-factor antagonist family
SMD11_RS13535	COG1595	DNA-templated transcription, initiation
SMD11_RS13570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMD11_RS13575	COG0596	Alpha beta hydrolase
SMD11_RS13575	COG2945	thiolester hydrolase activity
SMD11_RS13585	COG4821	SIS domain
SMD11_RS13595	COG0259	pyridoxamine-phosphate oxidase activity
SMD11_RS13630	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SMD11_RS13645	COG0247	lactate metabolic process
SMD11_RS13645	COG0277	FAD linked oxidase domain protein
SMD11_RS13655	COG2815	serine threonine protein kinase
SMD11_RS13655	COG0515	serine threonine protein kinase
SMD11_RS13660	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SMD11_RS13690	COG2188	Transcriptional regulator
SMD11_RS13745	COG0667	Aldo Keto reductase
SMD11_RS13755	COG2814	Major facilitator Superfamily
SMD11_RS13765	COG2252	PERMEase
SMD11_RS13795	COG2814	Major facilitator Superfamily
SMD11_RS13805	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SMD11_RS13810	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SMD11_RS13815	COG1278	Cold shock
SMD11_RS13825	COG0546	phosphoglycolate phosphatase activity
SMD11_RS13830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD11_RS13835	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD11_RS13840	COG1120	ATPase activity
SMD11_RS13855	COG1061	Type III restriction enzyme res subunit
SMD11_RS13865	COG3973	AAA domain
SMD11_RS13870	COG3142	Participates in the control of copper homeostasis
SMD11_RS13890	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SMD11_RS13895	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SMD11_RS13925	COG0463	Glycosyl transferase, family 2
SMD11_RS13930	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SMD11_RS13940	COG1877	trehalose-phosphatase activity
SMD11_RS13940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMD11_RS13955	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMD11_RS13990	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SMD11_RS13995	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SMD11_RS14010	COG0673	inositol 2-dehydrogenase activity
SMD11_RS14055	COG2197	response regulator
SMD11_RS14090	COG2409	Drug exporters of the RND superfamily
SMD11_RS14100	COG3842	ATPase activity
SMD11_RS14120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SMD11_RS14125	COG0215	cysteine-tRNA ligase activity
SMD11_RS14130	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SMD11_RS14135	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SMD11_RS14145	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SMD11_RS14150	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SMD11_RS14155	COG1329	Transcriptional regulator
SMD11_RS14175	COG5002	protein histidine kinase activity
SMD11_RS14200	COG0588	phosphoglycerate mutase activity
SMD11_RS14205	COG2211	Major facilitator Superfamily
SMD11_RS14215	COG0438	transferase activity, transferring glycosyl groups
SMD11_RS14225	COG0406	alpha-ribazole phosphatase activity
SMD11_RS14225	COG0494	nUDIX hydrolase
SMD11_RS14235	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SMD11_RS14260	COG0456	acetyltransferase
SMD11_RS14270	COG0737	Belongs to the 5'-nucleotidase family
SMD11_RS14285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMD11_RS14290	COG0745	RESPONSE REGULATOR receiver
SMD11_RS14295	COG2205	protein histidine kinase activity
SMD11_RS14305	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SMD11_RS14320	COG0702	epimerase
SMD11_RS14365	COG1609	Transcriptional regulator
SMD11_RS14370	COG0745	RESPONSE REGULATOR receiver
SMD11_RS14405	COG2897	thiosulfate sulfurtransferase activity
SMD11_RS14425	COG3485	protocatechuate 3,4-dioxygenase
SMD11_RS14430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD11_RS14435	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SMD11_RS14440	COG4607	ABC-type enterochelin transport system periplasmic component
SMD11_RS14455	COG1490	D-aminoacyl-tRNA deacylase activity
SMD11_RS14470	COG4552	Acetyltransferase involved in intracellular survival and related
SMD11_RS14485	COG1733	regulation of RNA biosynthetic process
SMD11_RS14505	COG0789	Transcriptional regulator
SMD11_RS14515	COG1595	DNA-templated transcription, initiation
SMD11_RS14540	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SMD11_RS14545	COG0791	NLP P60 protein
SMD11_RS14560	COG0581	inorganic phosphate transmembrane transporter activity
SMD11_RS14570	COG0306	phosphate transporter
SMD11_RS14580	COG1937	Protein conserved in bacteria
SMD11_RS14600	COG0277	FAD linked oxidase domain protein
SMD11_RS14605	COG0671	phosphoesterase, PA-phosphatase related
SMD11_RS14620	COG2815	serine threonine protein kinase
SMD11_RS14620	COG0515	serine threonine protein kinase
SMD11_RS14655	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SMD11_RS14685	COG4991	sh3 domain protein
SMD11_RS14695	COG0129	dihydroxy-acid dehydratase activity
SMD11_RS14705	COG1082	Xylose isomerase domain protein TIM barrel
SMD11_RS14710	COG0248	Ppx GppA phosphatase
SMD11_RS14730	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
SMD11_RS14740	COG0671	phosphoesterase, PA-phosphatase related
SMD11_RS14755	COG4585	Histidine kinase
SMD11_RS14765	COG1595	DNA-templated transcription, initiation
SMD11_RS14775	COG0745	RESPONSE REGULATOR receiver
SMD11_RS14780	COG2205	protein histidine kinase activity
SMD11_RS14785	COG0346	lactoylglutathione lyase activity
SMD11_RS14790	COG0739	heme binding
SMD11_RS14790	COG0741	lytic transglycosylase activity
SMD11_RS14790	COG1196	nuclear chromosome segregation
SMD11_RS14820	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SMD11_RS14840	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SMD11_RS14845	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SMD11_RS14850	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SMD11_RS14865	COG0640	Transcriptional regulator
SMD11_RS14870	COG2197	response regulator
SMD11_RS14885	COG0649	NAD binding
SMD11_RS14895	COG1732	Glycine betaine
SMD11_RS14900	COG1174	glycine betaine transport
SMD11_RS14905	COG1174	glycine betaine transport
SMD11_RS14910	COG1125	glycine betaine transport
SMD11_RS14910	COG0517	IMP dehydrogenase activity
SMD11_RS14920	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SMD11_RS14925	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SMD11_RS14935	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SMD11_RS14940	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SMD11_RS14940	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SMD11_RS14950	COG0302	gtp cyclohydrolase
SMD11_RS14965	COG0037	tRNA processing
SMD11_RS14975	COG2027	D-alanyl-D-alanine carboxypeptidase
SMD11_RS14980	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SMD11_RS14995	COG0393	Putative heavy-metal-binding
SMD11_RS15010	COG2318	DinB family
SMD11_RS15015	COG1012	belongs to the aldehyde dehydrogenase family
SMD11_RS15035	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SMD11_RS15045	COG0254	rRNA binding
SMD11_RS15050	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SMD11_RS15055	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SMD11_RS15060	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SMD11_RS15070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMD11_RS15070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMD11_RS15075	COG1077	Cell shape determining protein MreB Mrl
SMD11_RS15115	COG0583	DNA-binding transcription factor activity
SMD11_RS15125	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SMD11_RS15150	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SMD11_RS15150	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SMD11_RS15165	COG1725	Transcriptional regulator
SMD11_RS15225	COG0629	single-stranded DNA binding
SMD11_RS15265	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SMD11_RS15270	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SMD11_RS15275	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SMD11_RS15275	COG1754	DNA topoisomerase type I activity
SMD11_RS15280	COG2890	protein-(glutamine-N5) methyltransferase activity
SMD11_RS15290	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SMD11_RS15300	COG1366	Belongs to the anti-sigma-factor antagonist family
SMD11_RS15305	COG1111	helicase
SMD11_RS15305	COG1205	dead DEAH box helicase
SMD11_RS15365	COG0659	secondary active sulfate transmembrane transporter activity
SMD11_RS15370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMD11_RS15375	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SMD11_RS15385	COG2267	carboxylic ester hydrolase activity
SMD11_RS15510	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SMD11_RS15535	COG0003	Pfam Anion-transporting ATPase
SMD11_RS15560	COG1408	metallophosphoesterase
SMD11_RS15595	COG3346	SURF1 family
SMD11_RS15605	COG1595	DNA-templated transcription, initiation
SMD11_RS15625	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SMD11_RS15630	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SMD11_RS15685	COG2208	phosphoserine phosphatase activity
SMD11_RS15685	COG2770	Histidine kinase
SMD11_RS15700	COG1595	DNA-templated transcription, initiation
SMD11_RS15740	COG0583	DNA-binding transcription factor activity
SMD11_RS15745	COG2130	NADP-dependent
SMD11_RS15795	COG0433	COG0433 Predicted ATPase
SMD11_RS15855	COG1280	lysine exporter protein (LysE YggA)
SMD11_RS15880	COG2192	nodulation
SMD11_RS15905	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SMD11_RS15910	COG2130	NADP-dependent
SMD11_RS15920	COG0318	PFAM AMP-dependent synthetase and ligase
SMD11_RS15930	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SMD11_RS15935	COG2223	nitrite transmembrane transporter activity
SMD11_RS15940	COG0243	molybdopterin cofactor binding
SMD11_RS15945	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SMD11_RS15945	COG2146	nitrite reductase [NAD(P)H] activity
SMD11_RS15950	COG2146	nitrite reductase [NAD(P)H] activity
SMD11_RS15950	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SMD11_RS15955	COG1959	2 iron, 2 sulfur cluster binding
SMD11_RS15965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMD11_RS15980	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS15995	COG0655	NAD(P)H dehydrogenase (quinone) activity
SMD11_RS16000	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SMD11_RS16020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMD11_RS16025	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMD11_RS16030	COG2814	Major facilitator Superfamily
SMD11_RS16075	COG1191	sigma factor activity
SMD11_RS16080	COG1191	sigma factor activity
SMD11_RS16110	COG0477	Major facilitator Superfamily
SMD11_RS16115	COG0745	RESPONSE REGULATOR receiver
SMD11_RS16150	COG1309	transcriptional regulator
SMD11_RS16155	COG2814	Major facilitator Superfamily
SMD11_RS16170	COG0318	PFAM AMP-dependent synthetase and ligase
SMD11_RS16185	COG1595	DNA-templated transcription, initiation
SMD11_RS16215	COG2890	protein-(glutamine-N5) methyltransferase activity
SMD11_RS16270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMD11_RS16285	COG0653	protein targeting
SMD11_RS16305	COG0006	proline dipeptidase activity
SMD11_RS16315	COG2197	response regulator
SMD11_RS16320	COG4585	Histidine kinase
SMD11_RS16330	COG0583	DNA-binding transcription factor activity
SMD11_RS16345	COG0477	Major facilitator Superfamily
SMD11_RS16355	COG4585	Histidine kinase
SMD11_RS16360	COG2197	response regulator
SMD11_RS16375	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS16390	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMD11_RS16435	COG2372	response to copper ion
SMD11_RS16440	COG2837	iron assimilation
SMD11_RS16450	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SMD11_RS16455	COG0561	phosphatase activity
SMD11_RS16465	COG2186	Transcriptional regulator
SMD11_RS16470	COG2807	transmembrane transport
SMD11_RS16475	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
SMD11_RS16525	COG0501	Belongs to the peptidase M48B family
SMD11_RS16535	COG0561	phosphatase activity
SMD11_RS16540	COG0739	heme binding
SMD11_RS16550	COG4988	ABC transporter
SMD11_RS16555	COG1294	oxidase, subunit
SMD11_RS16560	COG1271	oxidase subunit
SMD11_RS16565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMD11_RS16570	COG1609	Transcriptional regulator
SMD11_RS16585	COG2304	oxidoreductase activity
SMD11_RS16615	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SMD11_RS16640	COG0662	Cupin 2, conserved barrel domain protein
SMD11_RS16645	COG1950	PFAM Membrane protein of
SMD11_RS16680	COG2814	Major facilitator Superfamily
SMD11_RS16695	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SMD11_RS16720	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMD11_RS16735	COG0242	peptide deformylase activity
SMD11_RS16745	COG0305	Participates in initiation and elongation during chromosome replication
SMD11_RS16760	COG0359	binds to the 23S rRNA
SMD11_RS16765	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SMD11_RS16770	COG0629	single-stranded DNA binding
SMD11_RS16775	COG0360	Binds together with S18 to 16S ribosomal RNA
SMD11_RS16800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMD11_RS16810	COG1260	myo-inositol-1-phosphate synthase
SMD11_RS16820	COG0617	tRNA 3'-terminal CCA addition
SMD11_RS16835	COG0515	serine threonine protein kinase
SMD11_RS16835	COG2815	serine threonine protein kinase
SMD11_RS16840	COG1595	DNA-templated transcription, initiation
SMD11_RS16850	COG0492	ferredoxin-NADP+ reductase activity
SMD11_RS16855	COG3118	belongs to the thioredoxin family
SMD11_RS16870	COG1192	Involved in chromosome partitioning
SMD11_RS16875	COG0357	Ribosomal RNA small subunit methyltransferase G
SMD11_RS16885	COG0706	membrane insertase activity
SMD11_RS16890	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SMD11_RS16895	COG0594	ribonuclease P activity
SMD11_RS16900	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SMD11_RS16915	COG0592	DNA-directed DNA polymerase activity
SMD11_RS16920	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SMD11_RS16925	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SMD11_RS16930	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
SMD11_RS16940	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SMD11_RS16965	COG0515	serine threonine protein kinase
SMD11_RS16990	COG0705	Rhomboid family
SMD11_RS17005	COG3764	Sortase (surface protein transpeptidase)
SMD11_RS17025	COG3764	Sortase (surface protein transpeptidase)
SMD11_RS17030	COG0515	serine threonine protein kinase
SMD11_RS17040	COG0768	penicillin binding
SMD11_RS17055	COG1716	ATPase activity
SMD11_RS17060	COG1716	ATPase activity
SMD11_RS17100	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SMD11_RS17110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SMD11_RS17115	COG2151	metal-sulfur cluster biosynthetic enzyme
SMD11_RS17120	COG3396	Phenylacetate-CoA oxygenase
SMD11_RS17125	COG3460	Phenylacetate-CoA oxygenase
SMD11_RS17130	COG3396	Phenylacetate-CoA oxygenase
SMD11_RS17155	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMD11_RS17160	COG1309	transcriptional regulator
SMD11_RS17165	COG1522	sequence-specific DNA binding
SMD11_RS17185	COG0746	molybdenum cofactor guanylyltransferase activity
SMD11_RS17190	COG0303	'Molybdopterin
SMD11_RS17200	COG3321	synthase
SMD11_RS17200	COG0604	alcohol dehydrogenase
SMD11_RS17200	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS17215	COG0515	serine threonine protein kinase
SMD11_RS17220	COG0515	serine threonine protein kinase
SMD11_RS17245	COG0022	dehydrogenase e1 component
SMD11_RS17250	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMD11_RS17295	COG1362	aminopeptidase activity
SMD11_RS17300	COG1960	acyl-CoA dehydrogenase activity
SMD11_RS17330	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SMD11_RS17340	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMD11_RS17360	COG0745	RESPONSE REGULATOR receiver
SMD11_RS17410	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS17430	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS17435	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS17540	COG0515	serine threonine protein kinase
SMD11_RS17540	COG2815	serine threonine protein kinase
SMD11_RS17570	COG0717	Belongs to the dCTP deaminase family
SMD11_RS17590	COG0247	lactate metabolic process
SMD11_RS17590	COG2181	nitrate reductase activity
SMD11_RS17595	COG0443	Heat shock 70 kDa protein
SMD11_RS17600	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SMD11_RS17605	COG0484	heat shock protein binding
SMD11_RS17610	COG0789	Transcriptional regulator
SMD11_RS17655	COG0789	Transcriptional regulator
SMD11_RS17680	COG0542	response to heat
SMD11_RS17705	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SMD11_RS17720	COG2910	NAD(P)H-binding
SMD11_RS17735	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SMD11_RS17745	COG0477	Major facilitator Superfamily
SMD11_RS17755	COG3483	tryptophan 2,3-dioxygenase activity
SMD11_RS17760	COG3844	kynureninase activity
SMD11_RS17775	COG2197	response regulator
SMD11_RS17785	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SMD11_RS17790	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMD11_RS17790	COG0515	serine threonine protein kinase
SMD11_RS17795	COG1278	Cold shock
SMD11_RS17800	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SMD11_RS17805	COG1802	Transcriptional regulator
SMD11_RS17825	COG0151	Belongs to the GarS family
SMD11_RS17840	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SMD11_RS17845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMD11_RS17855	COG0745	RESPONSE REGULATOR receiver
SMD11_RS17860	COG2205	protein histidine kinase activity
SMD11_RS17915	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SMD11_RS17920	COG0047	phosphoribosylformylglycinamidine synthase activity
SMD11_RS17925	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SMD11_RS17940	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SMD11_RS17975	COG1643	Atp-dependent helicase
SMD11_RS18005	COG0513	Belongs to the DEAD box helicase family
SMD11_RS18020	COG1278	Cold shock
SMD11_RS18040	COG2271	Major facilitator Superfamily
SMD11_RS18045	COG0667	Aldo Keto reductase
SMD11_RS18055	COG1846	Transcriptional regulator
SMD11_RS18105	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SMD11_RS18110	COG0579	oxidoreductase
SMD11_RS18135	COG1252	NADH dehydrogenase
SMD11_RS18175	COG1595	DNA-templated transcription, initiation
SMD11_RS18190	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SMD11_RS18195	COG0180	Tryptophanyl-tRNA synthetase
SMD11_RS18220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMD11_RS18225	COG0123	including yeast histone deacetylase and acetoin utilization protein
SMD11_RS18275	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SMD11_RS18280	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SMD11_RS18285	COG0181	hydroxymethylbilane synthase activity
SMD11_RS18290	COG1648	precorrin-2 dehydrogenase activity
SMD11_RS18290	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SMD11_RS18295	COG0113	porphobilinogen synthase activity
SMD11_RS18305	COG0018	arginyl-trna synthetase
SMD11_RS18310	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
SMD11_RS18325	COG1690	Belongs to the RtcB family
SMD11_RS18340	COG1742	UPF0060 membrane protein
SMD11_RS18365	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SMD11_RS18370	COG0406	alpha-ribazole phosphatase activity
SMD11_RS18390	COG1333	cytochrome c biogenesis protein
SMD11_RS18395	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SMD11_RS18415	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SMD11_RS18420	COG0109	protoheme IX farnesyltransferase activity
SMD11_RS18430	COG0163	prenyltransferase activity
SMD11_RS18440	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SMD11_RS18450	COG1301	dicarboxylic acid transport
SMD11_RS18480	COG1278	Cold shock
SMD11_RS18485	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SMD11_RS18490	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SMD11_RS18500	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SMD11_RS18510	COG2226	methyltransferase
SMD11_RS18530	COG3103	Sh3 type 3 domain protein
SMD11_RS18530	COG1388	LysM domain
SMD11_RS18530	COG0791	NLP P60 protein
SMD11_RS18540	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMD11_RS18545	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMD11_RS18550	COG0649	NAD binding
SMD11_RS18560	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SMD11_RS18565	COG1034	ATP synthesis coupled electron transport
SMD11_RS18570	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SMD11_RS18575	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMD11_RS18580	COG0839	Belongs to the complex I subunit 6 family
SMD11_RS18585	COG0713	ATP synthesis coupled electron transport
SMD11_RS18590	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SMD11_RS18600	COG1007	ATP synthesis coupled electron transport
SMD11_RS18625	COG0492	ferredoxin-NADP+ reductase activity
SMD11_RS18630	COG0142	geranyltranstransferase activity
SMD11_RS18650	COG4935	Belongs to the peptidase S8 family
SMD11_RS18650	COG2234	aminopeptidase activity
SMD11_RS18660	COG1013	pyruvate-flavodoxin oxidoreductase activity
SMD11_RS18665	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SMD11_RS18665	COG0674	pyruvate-flavodoxin oxidoreductase activity
SMD11_RS18675	COG4585	Histidine kinase
SMD11_RS18680	COG4585	Histidine kinase
SMD11_RS18685	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMD11_RS18690	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMD11_RS18695	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMD11_RS18700	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SMD11_RS18705	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMD11_RS18710	COG0839	Belongs to the complex I subunit 6 family
SMD11_RS18715	COG0713	ATP synthesis coupled electron transport
SMD11_RS18720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SMD11_RS18730	COG1007	ATP synthesis coupled electron transport
SMD11_RS18735	COG0501	Belongs to the peptidase M48B family
SMD11_RS18740	COG3304	Inner membrane component domain
SMD11_RS18745	COG1666	GTP binding
SMD11_RS18755	COG0702	epimerase
SMD11_RS18775	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SMD11_RS18780	COG2030	dehydratase
SMD11_RS18790	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SMD11_RS18795	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SMD11_RS18800	COG0436	Aminotransferase
SMD11_RS18820	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SMD11_RS18825	COG0081	regulation of translation
SMD11_RS18835	COG0222	ribosome binding
SMD11_RS18845	COG0085	RNA polymerase activity
SMD11_RS18850	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SMD11_RS18855	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SMD11_RS18860	COG0049	tRNA binding
SMD11_RS18865	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SMD11_RS18880	COG0051	transcription antitermination factor activity, RNA binding
SMD11_RS18885	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SMD11_RS18890	COG0088	Forms part of the polypeptide exit tunnel
SMD11_RS18895	COG0089	rRNA binding
SMD11_RS18900	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SMD11_RS18905	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SMD11_RS18910	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SMD11_RS18915	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SMD11_RS18920	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SMD11_RS18925	COG0255	Belongs to the universal ribosomal protein uL29 family
SMD11_RS18930	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SMD11_RS18935	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SMD11_RS18940	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SMD11_RS18945	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SMD11_RS18950	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SMD11_RS18960	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SMD11_RS18965	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SMD11_RS18970	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SMD11_RS18975	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SMD11_RS18985	COG0200	Binds to the 23S rRNA
SMD11_RS18995	COG0563	adenylate kinase activity
SMD11_RS19005	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SMD11_RS19010	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SMD11_RS19015	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SMD11_RS19020	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SMD11_RS19030	COG0203	ribosomal protein L17
SMD11_RS19035	COG0101	tRNA pseudouridine synthase activity
SMD11_RS19040	COG0438	transferase activity, transferring glycosyl groups
SMD11_RS19045	COG0438	transferase activity, transferring glycosyl groups
SMD11_RS19060	COG0488	(ABC) transporter
SMD11_RS19065	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SMD11_RS19070	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SMD11_RS19075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMD11_RS19085	COG1072	(Pantothenic acid kinase))
SMD11_RS19095	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMD11_RS19145	COG0789	Transcriptional regulator
SMD11_RS19160	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SMD11_RS19170	COG0802	atpase or kinase
SMD11_RS19195	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SMD11_RS19215	COG0726	polysaccharide deacetylase
SMD11_RS19220	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SMD11_RS19230	COG4221	oxidoreductase activity
SMD11_RS19240	COG0583	DNA-binding transcription factor activity
SMD11_RS19250	COG2197	response regulator
SMD11_RS19255	COG1595	DNA-templated transcription, initiation
SMD11_RS19265	COG0516	GMP reductase activity
SMD11_RS19275	COG1077	Cell shape determining protein MreB Mrl
SMD11_RS19285	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SMD11_RS19305	COG0318	PFAM AMP-dependent synthetase and ligase
SMD11_RS19315	COG1960	acyl-CoA dehydrogenase activity
SMD11_RS19335	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS19340	COG1960	acyl-CoA dehydrogenase activity
SMD11_RS19345	COG1012	belongs to the aldehyde dehydrogenase family
SMD11_RS19370	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SMD11_RS19375	COG1024	Enoyl-CoA hydratase
SMD11_RS19395	COG1960	acyl-CoA dehydrogenase activity
SMD11_RS19405	COG1309	transcriptional regulator
SMD11_RS19410	COG0515	serine threonine protein kinase
SMD11_RS19410	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMD11_RS19415	COG1024	Enoyl-CoA hydratase
SMD11_RS19455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD11_RS19505	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SMD11_RS19530	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SMD11_RS19560	COG1686	Belongs to the peptidase S11 family
SMD11_RS19620	COG0514	ATP-dependent DNA helicase (RecQ)
SMD11_RS19675	COG1846	Transcriptional regulator
SMD11_RS19680	COG3384	dioxygenase
SMD11_RS19705	COG0477	Major facilitator Superfamily
SMD11_RS19710	COG1349	DNA-binding transcription factor activity
SMD11_RS19715	COG1105	Belongs to the carbohydrate kinase PfkB family
SMD11_RS19735	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SMD11_RS19775	COG1725	Transcriptional regulator
SMD11_RS19780	COG1131	(ABC) transporter
SMD11_RS19800	COG3191	aminopeptidase activity
SMD11_RS19815	COG1970	mechanosensitive ion channel activity
SMD11_RS19820	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SMD11_RS19845	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SMD11_RS19850	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SMD11_RS19860	COG0315	cyclic pyranopterin monophosphate synthase activity
SMD11_RS19865	COG0521	Mo-molybdopterin cofactor biosynthetic process
SMD11_RS19865	COG0315	cyclic pyranopterin monophosphate synthase activity
SMD11_RS19870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMD11_RS19885	COG0483	inositol monophosphate 1-phosphatase activity
SMD11_RS19905	COG2205	protein histidine kinase activity
SMD11_RS19965	COG0789	Transcriptional regulator
SMD11_RS19970	COG2072	flavoprotein involved in K transport
SMD11_RS19975	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS19985	COG4946	Tricorn protease homolog
SMD11_RS19985	COG0793	Belongs to the peptidase S41A family
SMD11_RS19995	COG2409	Drug exporters of the RND superfamily
SMD11_RS20015	COG0310	cobalt ion transport
SMD11_RS20025	COG1122	ATPase activity
SMD11_RS20065	COG0084	hydrolase, TatD family'
SMD11_RS20075	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SMD11_RS20080	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SMD11_RS20100	COG0488	(ABC) transporter
SMD11_RS20125	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SMD11_RS20130	COG2197	response regulator
SMD11_RS20135	COG1846	Transcriptional regulator
SMD11_RS20140	COG4106	trans-aconitate 2-methyltransferase activity
SMD11_RS20145	COG1309	transcriptional regulator
SMD11_RS20155	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SMD11_RS20160	COG0193	aminoacyl-tRNA hydrolase activity
SMD11_RS20165	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SMD11_RS20170	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SMD11_RS20175	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SMD11_RS20185	COG4585	Histidine kinase
SMD11_RS20220	COG1136	(ABC) transporter
SMD11_RS20225	COG0577	efflux transmembrane transporter activity
SMD11_RS20255	COG2815	serine threonine protein kinase
SMD11_RS20255	COG0515	serine threonine protein kinase
SMD11_RS20280	COG2124	cytochrome p450
SMD11_RS20295	COG0148	phosphopyruvate hydratase activity
SMD11_RS20315	COG1252	NADH dehydrogenase
SMD11_RS20325	COG0577	efflux transmembrane transporter activity
SMD11_RS20330	COG1136	(ABC) transporter
SMD11_RS20350	COG2124	cytochrome p450
SMD11_RS20350	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SMD11_RS20355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD11_RS20355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMD11_RS20355	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS20355	COG3321	synthase
SMD11_RS20355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMD11_RS20365	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS20370	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS20375	COG1012	belongs to the aldehyde dehydrogenase family
SMD11_RS20380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD11_RS20385	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SMD11_RS20395	COG0822	iron-sulfur transferase activity
SMD11_RS20400	COG2814	Major facilitator Superfamily
SMD11_RS20405	COG0640	Transcriptional regulator
SMD11_RS20410	COG1309	transcriptional regulator
SMD11_RS20425	COG0318	PFAM AMP-dependent synthetase and ligase
SMD11_RS20455	COG0183	Belongs to the thiolase family
SMD11_RS20460	COG2755	lipolytic protein G-D-S-L family
SMD11_RS20475	COG0318	PFAM AMP-dependent synthetase and ligase
SMD11_RS20495	COG0019	diaminopimelate decarboxylase activity
SMD11_RS20500	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SMD11_RS20515	COG1228	amidohydrolase
SMD11_RS20530	COG1191	sigma factor activity
SMD11_RS20535	COG1366	Belongs to the anti-sigma-factor antagonist family
SMD11_RS20560	COG3104	oligopeptide transport
SMD11_RS20565	COG0745	RESPONSE REGULATOR receiver
SMD11_RS20570	COG2205	protein histidine kinase activity
SMD11_RS20600	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SMD11_RS20615	COG1316	TRANSCRIPTIONal
SMD11_RS20625	COG1316	TRANSCRIPTIONal
SMD11_RS20640	COG1316	TRANSCRIPTIONal
SMD11_RS20670	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
SMD11_RS20670	COG0778	Nitroreductase
SMD11_RS20675	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SMD11_RS20715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMD11_RS20720	COG2835	tetraacyldisaccharide 4'-kinase activity
SMD11_RS20730	COG1482	cell wall glycoprotein biosynthetic process
SMD11_RS20740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMD11_RS20740	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMD11_RS20740	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMD11_RS20745	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SMD11_RS20775	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SMD11_RS20780	COG0745	RESPONSE REGULATOR receiver
SMD11_RS20785	COG5000	phosphorelay sensor kinase activity
SMD11_RS20785	COG5002	protein histidine kinase activity
SMD11_RS20790	COG0823	Involved in the tonB-independent uptake of proteins
SMD11_RS20800	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SMD11_RS20805	COG2197	response regulator
SMD11_RS20820	COG0653	protein targeting
SMD11_RS20840	COG2902	Dehydrogenase
SMD11_RS20860	COG0463	Glycosyl transferase, family 2
SMD11_RS20885	COG1215	transferase activity, transferring glycosyl groups
SMD11_RS20895	COG0395	ABC-type sugar transport system, permease component
SMD11_RS20900	COG1175	transmembrane transport
SMD11_RS20905	COG1653	transport
SMD11_RS20915	COG0515	serine threonine protein kinase
SMD11_RS20920	COG0515	serine threonine protein kinase
SMD11_RS20925	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SMD11_RS20940	COG2884	Cell division ATP-binding protein ftsE
SMD11_RS20950	COG0793	Belongs to the peptidase S41A family
SMD11_RS20955	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SMD11_RS20995	COG3973	AAA domain
SMD11_RS21010	COG0776	regulation of translation
SMD11_RS21015	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SMD11_RS21020	COG1678	Uncharacterized ACR, COG1678
SMD11_RS21035	COG1175	transmembrane transport
SMD11_RS21040	COG0395	ABC-type sugar transport system, permease component
SMD11_RS21045	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SMD11_RS21060	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMD11_RS21090	COG0596	Alpha beta hydrolase
SMD11_RS21095	COG0583	DNA-binding transcription factor activity
SMD11_RS21105	COG2855	membrane
SMD11_RS21130	COG1732	Glycine betaine
SMD11_RS21135	COG1174	glycine betaine transport
SMD11_RS21145	COG1174	glycine betaine transport
SMD11_RS21155	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SMD11_RS21160	COG0277	FAD linked oxidase domain protein
SMD11_RS21195	COG1335	isochorismatase
SMD11_RS21205	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SMD11_RS21215	COG1113	amino acid transport
SMD11_RS21235	COG1234	tRNA 3'-trailer cleavage
SMD11_RS21240	COG1263	PTS System
SMD11_RS21245	COG1263	PTS System
SMD11_RS21250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMD11_RS21255	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SMD11_RS21265	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SMD11_RS21285	COG0477	Major facilitator Superfamily
SMD11_RS21295	COG2205	protein histidine kinase activity
SMD11_RS21310	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SMD11_RS21320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMD11_RS21340	COG2409	Drug exporters of the RND superfamily
SMD11_RS21350	COG2197	response regulator
SMD11_RS21365	COG2733	membrane
SMD11_RS21375	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SMD11_RS21425	COG1733	regulation of RNA biosynthetic process
SMD11_RS21430	COG2910	NAD(P)H-binding
SMD11_RS21450	COG4702	Belongs to the UPF0303 family
SMD11_RS21455	COG0673	inositol 2-dehydrogenase activity
SMD11_RS21470	COG2188	Transcriptional regulator
SMD11_RS21540	COG0741	lytic transglycosylase activity
SMD11_RS21540	COG0791	NLP P60 protein
SMD11_RS21570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD11_RS21595	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SMD11_RS21595	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SMD11_RS21600	COG4232	protein-disulfide reductase activity
SMD11_RS21605	COG3397	chitin binding
SMD11_RS21640	COG0406	alpha-ribazole phosphatase activity
SMD11_RS21685	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
SMD11_RS21690	COG4977	sequence-specific DNA binding
SMD11_RS21700	COG0589	response to stress
SMD11_RS21705	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMD11_RS21725	COG1960	acyl-CoA dehydrogenase activity
SMD11_RS21740	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SMD11_RS21745	COG1309	transcriptional regulator
SMD11_RS21755	COG1946	Acyl-CoA thioesterase
SMD11_RS21775	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SMD11_RS21810	COG0673	inositol 2-dehydrogenase activity
SMD11_RS21825	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SMD11_RS21850	COG3962	Belongs to the TPP enzyme family
SMD11_RS21855	COG3718	enzyme involved in inositol metabolism
SMD11_RS21875	COG0673	inositol 2-dehydrogenase activity
SMD11_RS21895	COG1289	transmembrane transporter activity
SMD11_RS21900	COG3226	Transcriptional regulator
SMD11_RS21915	COG2340	Cysteine-rich secretory protein family
SMD11_RS21920	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SMD11_RS21925	COG1053	succinate dehydrogenase
SMD11_RS21935	COG0583	DNA-binding transcription factor activity
SMD11_RS21940	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SMD11_RS21945	COG1993	acr, cog1993
SMD11_RS21950	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SMD11_RS22015	COG0629	single-stranded DNA binding
SMD11_RS22045	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SMD11_RS22075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMD11_RS22100	COG1486	melibiose metabolic process
SMD11_RS22105	COG0395	ABC-type sugar transport system, permease component
SMD11_RS22110	COG1175	transmembrane transport
SMD11_RS22120	COG1846	Transcriptional regulator
SMD11_RS22120	COG1940	carbohydrate kinase activity
SMD11_RS22130	COG0668	transmembrane transport
SMD11_RS22140	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SMD11_RS22140	COG3291	Pkd domain containing protein
SMD11_RS22210	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SMD11_RS22220	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SMD11_RS22230	COG1113	amino acid transport
SMD11_RS22235	COG1268	BioY protein
SMD11_RS22245	COG0515	serine threonine protein kinase
SMD11_RS22250	COG1113	amino acid transport
SMD11_RS22265	COG4552	Acetyltransferase involved in intracellular survival and related
SMD11_RS22280	COG3594	Acyltransferase
SMD11_RS22300	COG0544	peptidyl-prolyl cis-trans isomerase activity
SMD11_RS22305	COG0740	serine-type endopeptidase activity
SMD11_RS22310	COG0740	serine-type endopeptidase activity
SMD11_RS22315	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SMD11_RS22350	COG0525	valine-tRNA ligase activity
SMD11_RS22360	COG1215	transferase activity, transferring glycosyl groups
SMD11_RS22375	COG2205	protein histidine kinase activity
SMD11_RS22380	COG0768	penicillin binding
SMD11_RS22385	COG0285	dihydrofolate synthase activity
SMD11_RS22395	COG0105	UTP biosynthetic process
SMD11_RS22400	COG1077	Cell shape determining protein MreB Mrl
SMD11_RS22415	COG0768	penicillin binding
SMD11_RS22420	COG0772	Belongs to the SEDS family
SMD11_RS22440	COG1530	ribonuclease E activity
SMD11_RS22445	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SMD11_RS22450	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SMD11_RS22455	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SMD11_RS22465	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SMD11_RS22475	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SMD11_RS22490	COG0501	Belongs to the peptidase M48B family
SMD11_RS22500	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SMD11_RS22510	COG0799	negative regulation of ribosome biogenesis
SMD11_RS22515	COG0588	phosphoglycerate mutase activity
SMD11_RS22550	COG0495	leucyl-tRNA aminoacylation
SMD11_RS22560	COG1307	EDD domain protein, DegV family
SMD11_RS22590	COG0268	Binds directly to 16S ribosomal RNA
SMD11_RS22595	COG0481	GTPase activity
SMD11_RS22620	COG1420	regulation of RNA biosynthetic process
SMD11_RS22625	COG0484	heat shock protein binding
SMD11_RS22640	COG2197	response regulator
SMD11_RS22710	COG0463	Glycosyl transferase, family 2
SMD11_RS22740	COG0537	adenosine 5'-monophosphoramidase activity
SMD11_RS22745	COG1234	tRNA 3'-trailer cleavage
SMD11_RS22755	COG1486	melibiose metabolic process
SMD11_RS22760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMD11_RS22770	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SMD11_RS22800	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SMD11_RS22815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMD11_RS22860	COG1381	Involved in DNA repair and RecF pathway recombination
SMD11_RS22865	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SMD11_RS22875	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SMD11_RS22880	COG1120	ATPase activity
SMD11_RS22885	COG0803	Belongs to the bacterial solute-binding protein 9 family
SMD11_RS22885	COG3443	Belongs to the bacterial solute-binding protein 9 family
SMD11_RS22890	COG0423	glycine-tRNA ligase activity
SMD11_RS22900	COG2197	response regulator
SMD11_RS22910	COG0667	Aldo Keto reductase
SMD11_RS22915	COG0477	Major facilitator Superfamily
SMD11_RS22940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SMD11_RS22940	COG0574	Belongs to the PEP-utilizing enzyme family
SMD11_RS22950	COG0395	ABC-type sugar transport system, permease component
SMD11_RS22960	COG2182	Extracellular solute-binding protein
SMD11_RS22965	COG0531	amino acid
SMD11_RS22975	COG0300	oxidoreductase activity
SMD11_RS23000	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SMD11_RS23010	COG2949	membrane
SMD11_RS23015	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SMD11_RS23030	COG0358	DNA primase activity
SMD11_RS23040	COG1070	Carbohydrate kinase
SMD11_RS23065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMD11_RS23070	COG0406	alpha-ribazole phosphatase activity
SMD11_RS23090	COG1116	anion transmembrane transporter activity
SMD11_RS23110	COG2130	NADP-dependent
SMD11_RS23115	COG1764	response to oxidative stress
SMD11_RS23135	COG1285	pathogenesis
SMD11_RS23185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMD11_RS23190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMD11_RS23195	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMD11_RS23220	COG0789	Transcriptional regulator
SMD11_RS23225	COG0667	Aldo Keto reductase
SMD11_RS23230	COG2197	response regulator
SMD11_RS23235	COG4585	Histidine kinase
SMD11_RS23250	COG1309	transcriptional regulator
SMD11_RS23255	COG0477	Major facilitator Superfamily
SMD11_RS23265	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SMD11_RS23310	COG1358	cellular component organization or biogenesis
SMD11_RS23385	COG0583	DNA-binding transcription factor activity
SMD11_RS23410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMD11_RS23450	COG2124	cytochrome p450
SMD11_RS23455	COG0183	Belongs to the thiolase family
SMD11_RS23470	COG3845	ABC transporter
SMD11_RS23505	COG0515	serine threonine protein kinase
SMD11_RS23515	COG1132	(ABC) transporter
SMD11_RS23525	COG2197	response regulator
SMD11_RS23530	COG1309	transcriptional regulator
SMD11_RS23535	COG0438	transferase activity, transferring glycosyl groups
SMD11_RS23560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD11_RS23570	COG0860	N-Acetylmuramoyl-L-alanine amidase
SMD11_RS23580	COG2197	response regulator
SMD11_RS23585	COG4585	Histidine kinase
SMD11_RS23590	COG2030	dehydratase
SMD11_RS23600	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS23610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SMD11_RS23615	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SMD11_RS23635	COG0800	Aldolase
SMD11_RS23640	COG3022	response to hydroperoxide
SMD11_RS23645	COG0557	exoribonuclease II activity
SMD11_RS23670	COG4558	Periplasmic binding protein
SMD11_RS23675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD11_RS23680	COG1120	ATPase activity
SMD11_RS23685	COG2822	iron ion transport
SMD11_RS23690	COG2837	iron assimilation
SMD11_RS23710	COG1309	transcriptional regulator
SMD11_RS23720	COG1834	amidinotransferase
SMD11_RS23730	COG2814	Major facilitator Superfamily
SMD11_RS23735	COG3540	Alkaline phosphatase
SMD11_RS23775	COG1994	Peptidase M50
SMD11_RS23795	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SMD11_RS23800	COG0477	Major facilitator Superfamily
SMD11_RS23815	COG2814	Major facilitator Superfamily
SMD11_RS23840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMD11_RS23840	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SMD11_RS23845	COG2132	Multicopper oxidase
SMD11_RS23855	COG0531	amino acid
SMD11_RS23860	COG2267	carboxylic ester hydrolase activity
SMD11_RS23865	COG0174	glutamine synthetase
SMD11_RS23870	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SMD11_RS23880	COG1609	Transcriptional regulator
SMD11_RS23885	COG0366	Alpha amylase catalytic
SMD11_RS23890	COG3833	ABC-type maltose transport systems, permease component
SMD11_RS23925	COG2365	Tyrosine phosphatase family
SMD11_RS23940	COG2197	response regulator
SMD11_RS23950	COG0745	RESPONSE REGULATOR receiver
SMD11_RS23970	COG1136	(ABC) transporter
SMD11_RS24030	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SMD11_RS24035	COG0321	lipoyl(octanoyl) transferase activity
SMD11_RS24075	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMD11_RS24080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SMD11_RS24085	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SMD11_RS24090	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SMD11_RS24105	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SMD11_RS24105	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SMD11_RS24110	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SMD11_RS24125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMD11_RS24150	COG4585	Histidine kinase
SMD11_RS24155	COG2197	response regulator
SMD11_RS24160	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SMD11_RS24180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMD11_RS24190	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SMD11_RS24195	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SMD11_RS24205	COG1376	ErfK ybiS ycfS ynhG family protein
SMD11_RS24215	COG1845	cytochrome c oxidase, subunit III
SMD11_RS24220	COG2010	Cytochrome c
SMD11_RS24225	COG0723	plastoquinol--plastocyanin reductase activity
SMD11_RS24230	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SMD11_RS24235	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SMD11_RS24240	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SMD11_RS24285	COG0438	transferase activity, transferring glycosyl groups
SMD11_RS24305	COG0003	Pfam Anion-transporting ATPase
SMD11_RS24315	COG1940	carbohydrate kinase activity
SMD11_RS24345	COG2197	response regulator
SMD11_RS24350	COG0205	6-phosphofructokinase activity
SMD11_RS24360	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SMD11_RS24365	COG0243	molybdopterin cofactor binding
SMD11_RS24370	COG2193	ferroxidase activity
SMD11_RS24375	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SMD11_RS24380	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SMD11_RS24385	COG2815	serine threonine protein kinase
SMD11_RS24385	COG0515	serine threonine protein kinase
SMD11_RS24390	COG2022	thiamine diphosphate biosynthetic process
SMD11_RS24400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMD11_RS24400	COG2022	thiamine diphosphate biosynthetic process
SMD11_RS24415	COG0352	thiamine-phosphate diphosphorylase activity
SMD11_RS24430	COG1233	COG1233 Phytoene dehydrogenase and related
SMD11_RS24435	COG1309	transcriptional regulator
SMD11_RS24465	COG0714	Associated with various cellular activities
SMD11_RS24475	COG0275	rRNA processing
SMD11_RS24485	COG0768	penicillin binding
SMD11_RS24490	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SMD11_RS24500	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMD11_RS24505	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SMD11_RS24515	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SMD11_RS24520	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SMD11_RS24530	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SMD11_RS24545	COG1799	cell septum assembly
SMD11_RS24560	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SMD11_RS24575	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SMD11_RS24635	COG0587	DNA-directed DNA polymerase activity
SMD11_RS24640	COG1432	Conserved Protein
SMD11_RS24675	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SMD11_RS24680	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMD11_RS24685	COG0131	Imidazoleglycerol-phosphate dehydratase
SMD11_RS24690	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SMD11_RS24695	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SMD11_RS24700	COG0251	oxidation-reduction process
SMD11_RS24705	COG0107	imidazoleglycerol-phosphate synthase activity
SMD11_RS24710	COG2259	Doxx family
SMD11_RS24725	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SMD11_RS24750	COG0134	indole-3-glycerol-phosphate synthase activity
SMD11_RS24760	COG0133	tryptophan synthase activity
SMD11_RS24765	COG0159	tryptophan synthase activity
SMD11_RS24775	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SMD11_RS24785	COG0069	glutamate synthase activity
SMD11_RS24785	COG0070	glutamate synthase
SMD11_RS24785	COG0067	glutamate synthase
SMD11_RS24800	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SMD11_RS24805	COG1215	transferase activity, transferring glycosyl groups
SMD11_RS24835	COG2197	response regulator
SMD11_RS24845	COG0366	Alpha amylase catalytic
SMD11_RS24845	COG1470	cell adhesion involved in biofilm formation
SMD11_RS24860	COG0287	Prephenate dehydrogenase
SMD11_RS24860	COG1605	Chorismate mutase
SMD11_RS24870	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SMD11_RS24885	COG0737	Belongs to the 5'-nucleotidase family
SMD11_RS24920	COG0411	ABC transporter
SMD11_RS24940	COG2050	protein possibly involved in aromatic compounds catabolism
SMD11_RS24965	COG1643	Atp-dependent helicase
SMD11_RS24970	COG2226	methyltransferase
SMD11_RS24975	COG0539	negative regulation of cytoplasmic translation
SMD11_RS24985	COG0237	dephospho-CoA kinase activity
SMD11_RS25025	COG0584	glycerophosphoryl diester phosphodiesterase
SMD11_RS25030	COG0556	nucleotide-excision repair
SMD11_RS25050	COG0477	Major facilitator Superfamily
SMD11_RS25065	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SMD11_RS25095	COG0322	excinuclease ABC activity
SMD11_RS25100	COG1660	Displays ATPase and GTPase activities
SMD11_RS25105	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SMD11_RS25110	COG1481	regulation of sporulation
SMD11_RS25120	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SMD11_RS25125	COG0126	phosphoglycerate kinase activity
SMD11_RS25130	COG0149	triose-phosphate isomerase activity
SMD11_RS25135	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SMD11_RS25145	COG0166	Belongs to the GPI family
SMD11_RS25150	COG0363	glucosamine-6-phosphate deaminase activity
SMD11_RS25165	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SMD11_RS25170	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SMD11_RS25175	COG0109	protoheme IX farnesyltransferase activity
SMD11_RS25190	COG1612	heme a metabolic process
SMD11_RS25200	COG1131	(ABC) transporter
SMD11_RS25215	COG0719	Fe-S assembly protein
SMD11_RS25225	COG0396	ATPase activity
SMD11_RS25230	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SMD11_RS25235	COG0822	iron-sulfur transferase activity
SMD11_RS25250	COG2076	Multidrug Resistance protein
SMD11_RS25255	COG3226	Transcriptional regulator
SMD11_RS25260	COG2171	N-acyltransferase activity
SMD11_RS25265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMD11_RS25285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD11_RS25295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMD11_RS25300	COG2197	response regulator
SMD11_RS25310	COG0456	acetyltransferase
SMD11_RS25320	COG1917	Cupin 2, conserved barrel domain protein
SMD11_RS25325	COG5285	phytanoyl-CoA dioxygenase
SMD11_RS25330	COG2345	Transcriptional regulator
SMD11_RS25340	COG4585	Histidine kinase
SMD11_RS25345	COG0385	Bile acid
SMD11_RS25370	COG1797	cobyrinic acid a,c-diamide synthase activity
SMD11_RS25390	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SMD11_RS25405	COG0235	Class ii aldolase
SMD11_RS25430	COG0488	(ABC) transporter
SMD11_RS25440	COG1024	Enoyl-CoA hydratase
SMD11_RS25485	COG3387	PFAM Glycoside hydrolase 15-related
SMD11_RS25495	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SMD11_RS25525	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SMD11_RS25530	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SMD11_RS25545	COG2261	transglycosylase associated protein
SMD11_RS25550	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SMD11_RS25565	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS25570	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SMD11_RS25580	COG2807	transmembrane transport
SMD11_RS25595	COG3830	Belongs to the UPF0237 family
SMD11_RS25595	COG0560	Phosphoserine phosphatase
SMD11_RS25605	COG1131	(ABC) transporter
SMD11_RS25605	COG0842	Transport permease protein
SMD11_RS25605	COG1716	ATPase activity
SMD11_RS25620	COG3850	Histidine kinase
SMD11_RS25625	COG2197	response regulator
SMD11_RS25645	COG1119	ATPase activity
SMD11_RS25670	COG1881	PFAM PEBP family protein
SMD11_RS25690	COG2094	Belongs to the DNA glycosylase MPG family
SMD11_RS25720	COG0647	UMP catabolic process
SMD11_RS25735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD11_RS25740	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD11_RS25745	COG1120	ATPase activity
SMD11_RS25765	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SMD11_RS25775	COG0297	glycogen (starch) synthase activity
SMD11_RS25790	COG3387	PFAM Glycoside hydrolase 15-related
SMD11_RS25795	COG0504	CTP synthase activity
SMD11_RS25800	COG0494	nUDIX hydrolase
SMD11_RS25810	COG0686	Belongs to the AlaDH PNT family
SMD11_RS25825	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SMD11_RS25830	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SMD11_RS25835	COG1187	pseudouridine synthase activity
SMD11_RS25840	COG3541	Predicted nucleotidyltransferase
SMD11_RS25860	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SMD11_RS25870	COG1160	GTP binding
SMD11_RS25885	COG0438	transferase activity, transferring glycosyl groups
SMD11_RS25895	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SMD11_RS25945	COG0671	phosphoesterase, PA-phosphatase related
SMD11_RS25955	COG0477	Major facilitator Superfamily
SMD11_RS25960	COG1960	acyl-CoA dehydrogenase activity
SMD11_RS25965	COG1799	cell septum assembly
SMD11_RS25980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD11_RS26015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMD11_RS26020	COG4166	transmembrane transport
SMD11_RS26025	COG0601	transmembrane transport
SMD11_RS26045	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
SMD11_RS26065	COG0531	amino acid
SMD11_RS26095	COG0019	diaminopimelate decarboxylase activity
SMD11_RS26100	COG0367	asparagine synthase
SMD11_RS26105	COG1725	Transcriptional regulator
SMD11_RS26125	COG1649	PFAM Uncharacterised BCR, COG1649
SMD11_RS26125	COG0726	polysaccharide deacetylase
SMD11_RS26130	COG1215	transferase activity, transferring glycosyl groups
SMD11_RS26135	COG0463	Glycosyl transferase, family 2
SMD11_RS26155	COG0515	serine threonine protein kinase
SMD11_RS26185	COG2188	Transcriptional regulator
SMD11_RS26190	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
SMD11_RS26240	COG3876	Protein conserved in bacteria
SMD11_RS26275	COG2814	Major facilitator Superfamily
SMD11_RS26285	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SMD11_RS26315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMD11_RS26345	COG0667	Aldo Keto reductase
SMD11_RS26350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD11_RS26360	COG0598	Magnesium transport protein CorA
SMD11_RS26380	COG0215	cysteine-tRNA ligase activity
SMD11_RS26395	COG0477	Major facilitator Superfamily
SMD11_RS26405	COG3226	Transcriptional regulator
SMD11_RS26410	COG1410	methionine synthase
SMD11_RS26410	COG0646	methionine synthase
SMD11_RS26415	COG1414	Transcriptional regulator
SMD11_RS26420	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SMD11_RS26425	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SMD11_RS26430	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SMD11_RS26460	COG4166	transmembrane transport
SMD11_RS26470	COG2197	response regulator
SMD11_RS26480	COG0517	IMP dehydrogenase activity
SMD11_RS26480	COG1994	Peptidase M50
SMD11_RS26505	COG1222	aaa ATPase
SMD11_RS26510	COG4122	O-methyltransferase activity
SMD11_RS26525	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SMD11_RS26530	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SMD11_RS26535	COG1609	Transcriptional regulator
SMD11_RS26545	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SMD11_RS26580	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SMD11_RS26585	COG0805	protein transport
SMD11_RS26610	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMD11_RS26615	COG4175	Glycine betaine
SMD11_RS26615	COG0517	IMP dehydrogenase activity
SMD11_RS26640	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SMD11_RS26645	COG0531	amino acid
SMD11_RS26660	COG1012	belongs to the aldehyde dehydrogenase family
SMD11_RS26695	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SMD11_RS26705	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SMD11_RS26710	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SMD11_RS26715	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SMD11_RS26720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SMD11_RS26725	COG5002	protein histidine kinase activity
SMD11_RS26730	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SMD11_RS26735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMD11_RS26735	COG0072	phenylalanine-tRNA ligase activity
SMD11_RS26765	COG1649	PFAM Uncharacterised BCR, COG1649
SMD11_RS26785	COG0697	spore germination
SMD11_RS26800	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SMD11_RS26805	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SMD11_RS26810	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SMD11_RS26815	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMD11_RS26820	COG1438	arginine binding
SMD11_RS26825	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SMD11_RS26830	COG1113	amino acid transport
SMD11_RS26860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMD11_RS26875	COG2211	Major facilitator Superfamily
SMD11_RS26885	COG0697	spore germination
SMD11_RS26895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SMD11_RS26910	COG0137	argininosuccinate synthase activity
SMD11_RS26915	COG0165	Argininosuccinate lyase
SMD11_RS26925	COG0477	Major facilitator Superfamily
SMD11_RS26965	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SMD11_RS26975	COG1464	Belongs to the NlpA lipoprotein family
SMD11_RS26990	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SMD11_RS26995	COG1648	precorrin-2 dehydrogenase activity
SMD11_RS26995	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SMD11_RS27045	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SMD11_RS27115	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SMD11_RS27145	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SMD11_RS27150	COG1560	Kdo2-lipid A biosynthetic process
SMD11_RS27155	COG0438	transferase activity, transferring glycosyl groups
SMD11_RS27165	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SMD11_RS27170	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SMD11_RS27175	COG0217	transcriptional regulatory protein
SMD11_RS27180	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SMD11_RS27185	COG0632	four-way junction helicase activity
SMD11_RS27190	COG2255	four-way junction helicase activity
SMD11_RS27200	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SMD11_RS27205	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SMD11_RS27210	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SMD11_RS27220	COG1196	nuclear chromosome segregation
SMD11_RS27225	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SMD11_RS27235	COG0124	histidyl-tRNA synthetase
SMD11_RS27255	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SMD11_RS27275	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SMD11_RS27280	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SMD11_RS27290	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SMD11_RS27295	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SMD11_RS27300	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SMD11_RS27305	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SMD11_RS27310	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SMD11_RS27320	COG0006	proline dipeptidase activity
SMD11_RS27325	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SMD11_RS27330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMD11_RS27340	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SMD11_RS27345	COG0540	Belongs to the ATCase OTCase family
SMD11_RS27350	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SMD11_RS27360	COG0505	Belongs to the CarA family
SMD11_RS27365	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SMD11_RS27370	COG0167	dihydroorotate dehydrogenase activity
SMD11_RS27375	COG0284	orotidine-5'-phosphate decarboxylase activity
SMD11_RS27400	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SMD11_RS27415	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SMD11_RS27425	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SMD11_RS27430	COG2390	Transcriptional regulator
SMD11_RS27440	COG0531	amino acid
SMD11_RS27455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMD11_RS27475	COG2233	PERMEase
SMD11_RS27485	COG0738	Major facilitator superfamily
SMD11_RS27505	COG3201	nicotinamide mononucleotide transporter
SMD11_RS27510	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SMD11_RS27510	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SMD11_RS27515	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SMD11_RS27520	COG0140	phosphoribosyl-ATP diphosphatase activity
SMD11_RS27525	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SMD11_RS27585	COG2124	cytochrome p450
SMD11_RS27600	COG2814	Major facilitator Superfamily
SMD11_RS27610	COG0151	Belongs to the GarS family
SMD11_RS27635	COG2186	Transcriptional regulator
SMD11_RS27730	COG1012	belongs to the aldehyde dehydrogenase family
SMD11_RS27785	COG1120	ATPase activity
SMD11_RS27790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD11_RS27810	COG1461	Dihydroxyacetone kinase
SMD11_RS27825	COG1309	transcriptional regulator
SMD11_RS27830	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
SMD11_RS27840	COG1960	acyl-CoA dehydrogenase activity
SMD11_RS27865	COG0463	Glycosyl transferase, family 2
SMD11_RS27870	COG3030	protein affecting phage T7 exclusion by the F plasmid
SMD11_RS27885	COG2186	Transcriptional regulator
SMD11_RS27920	COG1793	dna ligase
SMD11_RS27935	COG0772	Belongs to the SEDS family
SMD11_RS27940	COG0642	Histidine kinase
SMD11_RS27945	COG0745	RESPONSE REGULATOR receiver
SMD11_RS27980	COG0277	FAD linked oxidase domain protein
SMD11_RS27995	COG1984	allophanate hydrolase subunit 2
SMD11_RS28000	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SMD11_RS28005	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SMD11_RS28010	COG2186	Transcriptional regulator
SMD11_RS28025	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SMD11_RS28080	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SMD11_RS28085	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SMD11_RS28100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMD11_RS28115	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SMD11_RS28150	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SMD11_RS28170	COG1716	ATPase activity
SMD11_RS28200	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SMD11_RS28200	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SMD11_RS28240	COG0697	spore germination
SMD11_RS28245	COG0697	spore germination
SMD11_RS28250	COG0583	DNA-binding transcription factor activity
SMD11_RS28285	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SMD11_RS28310	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SMD11_RS28345	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SMD11_RS28345	COG1672	PFAM Archaeal ATPase
SMD11_RS28350	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SMD11_RS28355	COG3285	dna ligase
SMD11_RS28355	COG1793	dna ligase
SMD11_RS28365	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SMD11_RS28365	COG1796	DNA polymerase
SMD11_RS28405	COG0475	glutathione-regulated potassium exporter activity
SMD11_RS28425	COG1968	undecaprenyl-diphosphatase activity
SMD11_RS28440	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SMD11_RS28510	COG4566	intracellular signal transduction
SMD11_RS28530	COG0110	maltose O-acetyltransferase activity
SMD11_RS28550	COG1739	Uncharacterized protein family UPF0029
SMD11_RS28560	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMD11_RS28575	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
SMD11_RS28615	COG0420	3'-5' exonuclease activity
SMD11_RS28620	COG0419	ATPase involved in DNA repair
SMD11_RS28625	COG1522	sequence-specific DNA binding
SMD11_RS28635	COG0656	L-ascorbic acid biosynthetic process
SMD11_RS28640	COG1446	asparaginase
SMD11_RS28665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SMD11_RS28685	COG1595	DNA-templated transcription, initiation
SMD11_RS28690	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS28695	COG2188	Transcriptional regulator
SMD11_RS28700	COG1940	carbohydrate kinase activity
SMD11_RS28705	COG2197	response regulator
SMD11_RS28710	COG4585	Histidine kinase
SMD11_RS28725	COG3663	DNA glycosylase
SMD11_RS28730	COG1970	mechanosensitive ion channel activity
SMD11_RS28735	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SMD11_RS28760	COG2226	methyltransferase
SMD11_RS28765	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SMD11_RS28770	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SMD11_RS28775	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SMD11_RS28780	COG0156	8-amino-7-oxononanoate synthase activity
SMD11_RS28805	COG0831	urea catabolic process
SMD11_RS28810	COG0832	Belongs to the urease beta subunit family
SMD11_RS28815	COG0804	urea catabolic process
SMD11_RS28825	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SMD11_RS28830	COG0829	nickel cation binding
SMD11_RS28865	COG0205	6-phosphofructokinase activity
SMD11_RS28870	COG3442	glutamine amidotransferase
SMD11_RS28880	COG0242	peptide deformylase activity
SMD11_RS28890	COG1960	acyl-CoA dehydrogenase activity
SMD11_RS28930	COG0583	DNA-binding transcription factor activity
SMD11_RS28950	COG0596	Alpha beta hydrolase
SMD11_RS28985	COG1960	acyl-CoA dehydrogenase activity
SMD11_RS28995	COG1511	domain protein
SMD11_RS29025	COG1131	(ABC) transporter
SMD11_RS29060	COG3629	intracellular signal transduction
SMD11_RS29060	COG3903	Transcriptional regulator
SMD11_RS29070	COG2070	2-Nitropropane dioxygenase
SMD11_RS29080	COG2366	antibiotic biosynthetic process
SMD11_RS29085	COG0318	PFAM AMP-dependent synthetase and ligase
SMD11_RS29140	COG3226	Transcriptional regulator
SMD11_RS29155	COG0510	thiamine kinase activity
SMD11_RS29200	COG0438	transferase activity, transferring glycosyl groups
SMD11_RS29210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMD11_RS29215	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SMD11_RS29235	COG3012	SEC-C Motif Domain Protein
SMD11_RS29255	COG4585	Histidine kinase
SMD11_RS29295	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SMD11_RS29300	COG0791	NLP P60 protein
SMD11_RS29315	COG2223	nitrite transmembrane transporter activity
SMD11_RS29320	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SMD11_RS29320	COG2146	nitrite reductase [NAD(P)H] activity
SMD11_RS29330	COG0243	molybdopterin cofactor binding
SMD11_RS29365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMD11_RS29375	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMD11_RS29380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMD11_RS29385	COG0318	PFAM AMP-dependent synthetase and ligase
SMD11_RS29390	COG2050	protein possibly involved in aromatic compounds catabolism
SMD11_RS29395	COG0477	Major facilitator Superfamily
SMD11_RS29400	COG0367	asparagine synthase
SMD11_RS29430	COG0583	DNA-binding transcription factor activity
SMD11_RS29445	COG1278	Cold shock
SMD11_RS29450	COG1316	TRANSCRIPTIONal
SMD11_RS29485	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SMD11_RS29495	COG1247	-acetyltransferase
SMD11_RS29500	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMD11_RS29505	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SMD11_RS29510	COG2080	2 iron, 2 sulfur cluster binding
SMD11_RS29550	COG1011	Hydrolase
SMD11_RS29560	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SMD11_RS29565	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMD11_RS29680	COG0174	glutamine synthetase
SMD11_RS29705	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS29705	COG3321	synthase
SMD11_RS29705	COG0604	alcohol dehydrogenase
SMD11_RS29710	COG0477	Major facilitator Superfamily
SMD11_RS29760	COG0745	RESPONSE REGULATOR receiver
SMD11_RS29765	COG0604	alcohol dehydrogenase
SMD11_RS29765	COG3321	synthase
SMD11_RS29770	COG4770	biotin carboxylase activity
SMD11_RS29805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMD11_RS29835	COG3321	synthase
SMD11_RS29835	COG0604	alcohol dehydrogenase
SMD11_RS29835	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS29845	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SMD11_RS29890	COG1121	(ABC) transporter
SMD11_RS29895	COG0142	geranyltranstransferase activity
SMD11_RS29925	COG1357	PFAM Pentapeptide repeats (8 copies)
SMD11_RS29950	COG3629	intracellular signal transduction
SMD11_RS29965	COG0367	asparagine synthase
SMD11_RS29975	COG3321	synthase
SMD11_RS29975	COG0300	oxidoreductase activity
SMD11_RS29975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMD11_RS29975	COG4221	oxidoreductase activity
SMD11_RS29980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD11_RS29980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD11_RS29985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD11_RS29995	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SMD11_RS30000	COG2423	ornithine cyclodeaminase activity
SMD11_RS30010	COG2340	Cysteine-rich secretory protein family
SMD11_RS30020	COG0494	nUDIX hydrolase
SMD11_RS30050	COG1396	sequence-specific DNA binding
SMD11_RS30090	COG3903	Transcriptional regulator
SMD11_RS30090	COG3629	intracellular signal transduction
SMD11_RS30105	COG4585	Histidine kinase
SMD11_RS30110	COG2197	response regulator
SMD11_RS30130	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SMD11_RS30150	COG4566	intracellular signal transduction
SMD11_RS30160	COG0300	oxidoreductase activity
SMD11_RS30170	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD11_RS30235	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS30310	COG2124	cytochrome p450
SMD11_RS30315	COG0142	geranyltranstransferase activity
SMD11_RS30320	COG2124	cytochrome p450
SMD11_RS30355	COG0477	Major facilitator Superfamily
SMD11_RS30370	COG0667	Aldo Keto reductase
SMD11_RS30380	COG3118	belongs to the thioredoxin family
SMD11_RS30430	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SMD11_RS30470	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS30470	COG0604	alcohol dehydrogenase
SMD11_RS30470	COG3321	synthase
SMD11_RS30475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMD11_RS30490	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SMD11_RS30490	COG2124	cytochrome p450
SMD11_RS30555	COG2197	response regulator
SMD11_RS30590	COG1090	epimerase
SMD11_RS30595	COG0346	lactoylglutathione lyase activity
SMD11_RS30625	COG2267	carboxylic ester hydrolase activity
SMD11_RS30640	COG0702	epimerase
SMD11_RS30650	COG0681	Belongs to the peptidase S26 family
SMD11_RS30680	COG0163	prenyltransferase activity
SMD11_RS30685	COG0583	DNA-binding transcription factor activity
SMD11_RS30700	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
SMD11_RS30705	COG1120	ATPase activity
SMD11_RS30720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMD11_RS30725	COG1595	DNA-templated transcription, initiation
SMD11_RS30730	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMD11_RS30740	COG0745	RESPONSE REGULATOR receiver
SMD11_RS30745	COG2205	protein histidine kinase activity
SMD11_RS30760	COG0667	Aldo Keto reductase
SMD11_RS30770	COG0596	Alpha beta hydrolase
SMD11_RS30805	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SMD11_RS30815	COG1309	transcriptional regulator
SMD11_RS30830	COG0583	DNA-binding transcription factor activity
SMD11_RS30855	COG2015	COG2015, Alkyl sulfatase and related hydrolases
SMD11_RS30875	COG3268	Saccharopine dehydrogenase
SMD11_RS30885	COG3979	chitinase
SMD11_RS30895	COG0745	RESPONSE REGULATOR receiver
SMD11_RS30905	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SMD11_RS30910	COG4044	May play a role in the intracellular transport of hydrophobic ligands
SMD11_RS30925	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMD11_RS30930	COG1129	ABC transporter
SMD11_RS30965	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SMD11_RS30970	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMD11_RS30975	COG1278	Cold shock
SMD11_RS30980	COG0513	Belongs to the DEAD box helicase family
SMD11_RS31010	COG0387	Pfam Sodium calcium exchanger
SMD11_RS31030	COG0531	amino acid
SMD11_RS31050	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SMD11_RS31075	COG1113	amino acid transport
SMD11_RS31080	COG0659	secondary active sulfate transmembrane transporter activity
SMD11_RS31090	COG2222	sugar isomerase
SMD11_RS31125	COG2207	Transcriptional regulator
SMD11_RS31135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMD11_RS31155	COG1752	Esterase of the alpha-beta hydrolase superfamily
SMD11_RS31170	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SMD11_RS31175	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SMD11_RS31180	COG3486	L-lysine 6-monooxygenase (NADPH) activity
SMD11_RS31205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD11_RS31220	COG2234	aminopeptidase activity
SMD11_RS31230	COG1132	(ABC) transporter
SMD11_RS31235	COG1132	(ABC) transporter
SMD11_RS31240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD11_RS31245	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD11_RS31255	COG1982	Orn Lys Arg decarboxylase major
SMD11_RS31285	COG1132	(ABC) transporter
SMD11_RS31325	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SMD11_RS31335	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SMD11_RS31370	COG1024	Enoyl-CoA hydratase
SMD11_RS31385	COG3800	Transcriptional regulator
SMD11_RS31385	COG1396	sequence-specific DNA binding
SMD11_RS31390	COG2079	MmgE PrpD family protein
SMD11_RS31395	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SMD11_RS31485	COG1132	(ABC) transporter
SMD11_RS31525	COG1309	transcriptional regulator
SMD11_RS31530	COG2814	Major facilitator Superfamily
SMD11_RS31540	COG2226	methyltransferase
SMD11_RS31620	COG2205	protein histidine kinase activity
SMD11_RS31625	COG1733	regulation of RNA biosynthetic process
SMD11_RS31635	COG2814	Major facilitator Superfamily
SMD11_RS31650	COG0386	Belongs to the glutathione peroxidase family
SMD11_RS31655	COG0189	ligase activity
SMD11_RS31730	COG1132	(ABC) transporter
SMD11_RS31735	COG2124	cytochrome p450
SMD11_RS31755	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SMD11_RS31780	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SMD11_RS31790	COG1064	alcohol dehydrogenase
SMD11_RS31815	COG1716	ATPase activity
SMD11_RS31815	COG1131	(ABC) transporter
SMD11_RS31815	COG0842	Transport permease protein
SMD11_RS31870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMD11_RS31870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMD11_RS31895	COG2208	phosphoserine phosphatase activity
SMD11_RS31900	COG1113	amino acid transport
SMD11_RS31910	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SMD11_RS31915	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SMD11_RS31965	COG1733	regulation of RNA biosynthetic process
SMD11_RS31980	COG2813	Specifically methylates the guanine in position
SMD11_RS31995	COG0318	PFAM AMP-dependent synthetase and ligase
SMD11_RS32010	COG0431	NADPH-dependent FMN reductase
SMD11_RS32015	COG1793	dna ligase
SMD11_RS32095	COG0110	maltose O-acetyltransferase activity
SMD11_RS32110	COG3290	protein histidine kinase activity
SMD11_RS32120	COG2197	response regulator
SMD11_RS32130	COG1132	(ABC) transporter
SMD11_RS32170	COG0531	amino acid
SMD11_RS32200	COG2814	Major facilitator Superfamily
SMD11_RS32230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD11_RS32280	COG0784	Response regulator, receiver
SMD11_RS32280	COG2205	protein histidine kinase activity
SMD11_RS32280	COG5002	protein histidine kinase activity
SMD11_RS32325	COG3321	synthase
SMD11_RS32325	COG0604	alcohol dehydrogenase
SMD11_RS32335	COG3321	synthase
SMD11_RS32335	COG0604	alcohol dehydrogenase
SMD11_RS32350	COG3321	synthase
SMD11_RS32350	COG0604	alcohol dehydrogenase
SMD11_RS32350	COG3321	synthase
SMD11_RS32350	COG0604	alcohol dehydrogenase
SMD11_RS32365	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SMD11_RS32390	COG2135	peptidase activity
SMD11_RS32425	COG2205	protein histidine kinase activity
SMD11_RS32435	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS32450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMD11_RS32460	COG2986	histidine ammonia-lyase
SMD11_RS32520	COG0154	amidase activity
SMD11_RS32525	COG2814	Major facilitator Superfamily
SMD11_RS32530	COG2890	protein-(glutamine-N5) methyltransferase activity
SMD11_RS32535	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SMD11_RS32545	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SMD11_RS32580	COG2814	Major facilitator Superfamily
SMD11_RS32585	COG0183	Belongs to the thiolase family
SMD11_RS32590	COG0318	PFAM AMP-dependent synthetase and ligase
SMD11_RS32595	COG1268	BioY protein
SMD11_RS32600	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SMD11_RS32605	COG1122	ATPase activity
SMD11_RS32620	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SMD11_RS32625	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SMD11_RS32630	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SMD11_RS32645	COG0156	8-amino-7-oxononanoate synthase activity
SMD11_RS32650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMD11_RS32655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMD11_RS32665	COG1846	Transcriptional regulator
SMD11_RS32670	COG0702	epimerase
SMD11_RS32690	COG2072	flavoprotein involved in K transport
SMD11_RS32700	COG0531	amino acid
SMD11_RS32725	COG2814	Major facilitator Superfamily
SMD11_RS32735	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SMD11_RS32740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMD11_RS32755	COG1819	glycosyl
SMD11_RS32795	COG2910	NAD(P)H-binding
SMD11_RS32835	COG1063	alcohol dehydrogenase
SMD11_RS32895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMD11_RS32925	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMD11_RS32940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD11_RS32955	COG3958	Transketolase
SMD11_RS32960	COG3959	Transketolase, thiamine diphosphate binding domain
SMD11_RS32965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMD11_RS32970	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SMD11_RS32975	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SMD11_RS32980	COG0189	ligase activity
SMD11_RS32995	COG0529	Catalyzes the synthesis of activated sulfate
SMD11_RS32995	COG2046	Belongs to the sulfate adenylyltransferase family
SMD11_RS33015	COG1960	acyl-CoA dehydrogenase activity
SMD11_RS33020	COG1960	acyl-CoA dehydrogenase activity
SMD11_RS33025	COG2267	carboxylic ester hydrolase activity
SMD11_RS33030	COG0697	spore germination
SMD11_RS33035	COG1846	Transcriptional regulator
SMD11_RS33040	COG2824	Alkylphosphonate utilization operon protein PhnA
SMD11_RS33055	COG2197	response regulator
SMD11_RS33065	COG0318	PFAM AMP-dependent synthetase and ligase
SMD11_RS33070	COG0583	DNA-binding transcription factor activity
SMD11_RS33075	COG1819	glycosyl
SMD11_RS33095	COG0823	Involved in the tonB-independent uptake of proteins
SMD11_RS33105	COG0464	growth
SMD11_RS33180	COG0367	asparagine synthase
SMD11_RS33190	COG0494	nUDIX hydrolase
SMD11_RS33200	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS33205	COG0563	adenylate kinase activity
SMD11_RS33225	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS33230	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
SMD11_RS33235	COG1260	myo-inositol-1-phosphate synthase
SMD11_RS33250	COG1960	acyl-CoA dehydrogenase activity
SMD11_RS33265	COG1131	(ABC) transporter
SMD11_RS33295	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMD11_RS33300	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SMD11_RS33305	COG2080	2 iron, 2 sulfur cluster binding
SMD11_RS33320	COG2226	methyltransferase
SMD11_RS33375	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SMD11_RS33375	COG0574	Belongs to the PEP-utilizing enzyme family
SMD11_RS33390	COG0688	phosphatidylethanolamine metabolic process
SMD11_RS33395	COG3220	belongs to the UPF0276 family
SMD11_RS33420	COG2124	cytochrome p450
SMD11_RS33440	COG3903	Transcriptional regulator
SMD11_RS33440	COG2197	response regulator
SMD11_RS33450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMD11_RS33470	COG0493	'glutamate synthase
SMD11_RS33480	COG1021	2,3-dihydroxybenzoate-AMP ligase
SMD11_RS33485	COG1028	Short-chain dehydrogenase reductase Sdr
SMD11_RS33505	COG1917	Cupin 2, conserved barrel domain protein
SMD11_RS33510	COG5285	phytanoyl-CoA dioxygenase
SMD11_RS33520	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SMD11_RS33540	COG0583	DNA-binding transcription factor activity
SMD11_RS33550	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMD11_RS33560	COG1794	racemase activity, acting on amino acids and derivatives
SMD11_RS33570	COG2409	Drug exporters of the RND superfamily
SMD11_RS33575	COG1946	Acyl-CoA thioesterase
SMD11_RS33585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMD11_RS33590	COG0604	alcohol dehydrogenase
SMD11_RS33590	COG3321	synthase
SMD11_RS33595	COG2610	gluconate transmembrane transporter activity
SMD11_RS33605	COG0076	glutamate decarboxylase activity
SMD11_RS33710	COG0583	DNA-binding transcription factor activity
SMD11_RS33715	COG0667	Aldo Keto reductase
SMD11_RS33760	COG0542	response to heat
SMD11_RS33840	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SMD11_RS33850	COG1070	Carbohydrate kinase
SMD11_RS33855	COG1070	Carbohydrate kinase
SMD11_RS33865	COG2814	Major facilitator Superfamily
SMD11_RS33920	COG1574	metal-dependent hydrolase with the TIM-barrel fold
SMD11_RS33940	COG0109	protoheme IX farnesyltransferase activity
SMD11_RS34015	COG3548	integral membrane protein
SMD11_RS34030	COG0477	Major facilitator Superfamily
SMD11_RS34055	COG0142	geranyltranstransferase activity
SMD11_RS34060	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SMD11_RS34100	COG2124	cytochrome p450
SMD11_RS34165	COG0402	S-adenosylhomocysteine deaminase activity
SMD11_RS34210	COG2066	Belongs to the glutaminase family
SMD11_RS34215	COG0477	Major facilitator Superfamily
SMD11_RS34220	COG1846	Transcriptional regulator
SMD11_RS34245	COG4974	Belongs to the 'phage' integrase family
SMD11_RS34310	COG1104	cysteine desulfurase activity
SMD11_RS34320	COG3320	Male sterility
SMD11_RS34320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMD11_RS34360	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SMD11_RS34390	COG0463	Glycosyl transferase, family 2
SMD11_RS34390	COG0457	Tetratricopeptide repeat
SMD11_RS34425	COG1434	Gram-negative-bacterium-type cell wall biogenesis
SMD11_RS34435	COG0535	radical SAM domain protein
SMD11_RS34490	COG0148	phosphopyruvate hydratase activity
SMD11_RS34565	COG1132	(ABC) transporter
SMD11_RS34595	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SMD11_RS34765	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SMD11_RS34810	COG3953	SLT domain
SMD11_RS34810	COG5412	phage tail tape measure protein
SMD11_RS34835	COG3320	Male sterility
SMD11_RS34835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMD11_RS34985	COG1653	transport