locus-tag	class	description
SMD44_RS00085	COG0242	peptide deformylase activity
SMD44_RS00185	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS00195	COG0028	Belongs to the TPP enzyme family
SMD44_RS00225	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SMD44_RS00255	COG3629	intracellular signal transduction
SMD44_RS00255	COG3903	Transcriptional regulator
SMD44_RS00275	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SMD44_RS00290	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
SMD44_RS00295	COG4948	Mandelate Racemase Muconate Lactonizing
SMD44_RS00330	COG1921	L-seryl-tRNASec selenium transferase activity
SMD44_RS00340	COG0667	Aldo Keto reductase
SMD44_RS00360	COG2197	response regulator
SMD44_RS00365	COG4585	Histidine kinase
SMD44_RS00370	COG2132	Multicopper oxidase
SMD44_RS00450	COG0539	negative regulation of cytoplasmic translation
SMD44_RS00460	COG1234	tRNA 3'-trailer cleavage
SMD44_RS00505	COG0667	Aldo Keto reductase
SMD44_RS00530	COG1595	DNA-templated transcription, initiation
SMD44_RS00570	COG0702	epimerase
SMD44_RS00575	COG1309	transcriptional regulator
SMD44_RS00620	COG2197	response regulator
SMD44_RS00625	COG4585	Histidine kinase
SMD44_RS00630	COG2409	Drug exporters of the RND superfamily
SMD44_RS00640	COG0488	(ABC) transporter
SMD44_RS00655	COG0402	S-adenosylhomocysteine deaminase activity
SMD44_RS00665	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS00670	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
SMD44_RS00675	COG2318	DinB family
SMD44_RS00685	COG1309	transcriptional regulator
SMD44_RS00695	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SMD44_RS00715	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMD44_RS00725	COG1595	DNA-templated transcription, initiation
SMD44_RS00740	COG1231	oxidoreductase activity
SMD44_RS00765	COG2945	thiolester hydrolase activity
SMD44_RS00765	COG0596	Alpha beta hydrolase
SMD44_RS00770	COG1309	transcriptional regulator
SMD44_RS00780	COG0604	alcohol dehydrogenase
SMD44_RS00780	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS00780	COG3321	synthase
SMD44_RS00795	COG4249	Peptidase C14 caspase catalytic subunit p20
SMD44_RS00795	COG2319	Wd-40 repeat
SMD44_RS00805	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SMD44_RS00815	COG3629	intracellular signal transduction
SMD44_RS00815	COG3903	Transcriptional regulator
SMD44_RS00830	COG0604	alcohol dehydrogenase
SMD44_RS00845	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SMD44_RS00900	COG2197	response regulator
SMD44_RS00940	COG0745	RESPONSE REGULATOR receiver
SMD44_RS00955	COG2207	Transcriptional regulator
SMD44_RS00955	COG3708	Transcriptional regulator
SMD44_RS01025	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SMD44_RS01030	COG2079	MmgE PrpD family protein
SMD44_RS01035	COG3800	Transcriptional regulator
SMD44_RS01035	COG1396	sequence-specific DNA binding
SMD44_RS01050	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SMD44_RS01060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMD44_RS01070	COG1780	Probably involved in ribonucleotide reductase function
SMD44_RS01075	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMD44_RS01085	COG0301	tRNA thio-modification
SMD44_RS01090	COG1051	belongs to the nudix hydrolase family
SMD44_RS01095	COG3896	Chloramphenicol phosphotransferase-like protein
SMD44_RS01100	COG4977	sequence-specific DNA binding
SMD44_RS01110	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMD44_RS01110	COG0515	serine threonine protein kinase
SMD44_RS01135	COG2318	DinB family
SMD44_RS01150	COG0667	Aldo Keto reductase
SMD44_RS01160	COG1819	glycosyl
SMD44_RS01165	COG2205	protein histidine kinase activity
SMD44_RS01165	COG2972	Histidine kinase
SMD44_RS01205	COG2814	Major facilitator Superfamily
SMD44_RS01225	COG2205	protein histidine kinase activity
SMD44_RS01230	COG0745	RESPONSE REGULATOR receiver
SMD44_RS01245	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SMD44_RS01250	COG1169	isochorismate synthase
SMD44_RS01255	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS01265	COG1078	dGTPase activity
SMD44_RS01290	COG1846	Transcriptional regulator
SMD44_RS01335	COG2376	Dihydroxyacetone kinase
SMD44_RS01355	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SMD44_RS01360	COG4585	Histidine kinase
SMD44_RS01365	COG2197	response regulator
SMD44_RS01445	COG2272	Belongs to the type-B carboxylesterase lipase family
SMD44_RS01450	COG1309	transcriptional regulator
SMD44_RS01470	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD44_RS01475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD44_RS01485	COG2375	cellular response to nickel ion
SMD44_RS01505	COG0395	ABC-type sugar transport system, permease component
SMD44_RS01515	COG1609	Transcriptional regulator
SMD44_RS01550	COG0148	phosphopyruvate hydratase activity
SMD44_RS01575	COG2340	Cysteine-rich secretory protein family
SMD44_RS01585	COG2186	Transcriptional regulator
SMD44_RS01605	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS01640	COG2814	Major facilitator Superfamily
SMD44_RS01660	COG0667	Aldo Keto reductase
SMD44_RS01665	COG4552	Acetyltransferase involved in intracellular survival and related
SMD44_RS01690	COG1132	(ABC) transporter
SMD44_RS01710	COG2207	Transcriptional regulator
SMD44_RS01730	COG1309	transcriptional regulator
SMD44_RS01735	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS01740	COG1796	DNA polymerase
SMD44_RS01740	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SMD44_RS01790	COG4948	Mandelate Racemase Muconate Lactonizing
SMD44_RS01850	COG1024	Enoyl-CoA hydratase
SMD44_RS01860	COG2226	methyltransferase
SMD44_RS01865	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SMD44_RS01880	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS01890	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMD44_RS01895	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMD44_RS01910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMD44_RS01930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMD44_RS01965	COG3903	Transcriptional regulator
SMD44_RS01965	COG3629	intracellular signal transduction
SMD44_RS01990	COG0745	RESPONSE REGULATOR receiver
SMD44_RS02000	COG1686	Belongs to the peptidase S11 family
SMD44_RS02025	COG2066	Belongs to the glutaminase family
SMD44_RS02030	COG1486	melibiose metabolic process
SMD44_RS02035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMD44_RS02040	COG0395	ABC-type sugar transport system, permease component
SMD44_RS02070	COG0778	Nitroreductase
SMD44_RS02100	COG0583	DNA-binding transcription factor activity
SMD44_RS02135	COG4221	oxidoreductase activity
SMD44_RS02150	COG1309	transcriptional regulator
SMD44_RS02165	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS02195	COG2124	cytochrome p450
SMD44_RS02220	COG0789	Transcriptional regulator
SMD44_RS02245	COG3408	Glycogen debranching enzyme
SMD44_RS02245	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
SMD44_RS02260	COG3321	synthase
SMD44_RS02260	COG0604	alcohol dehydrogenase
SMD44_RS02295	COG0657	acetylesterase activity
SMD44_RS02330	COG3622	Belongs to the hyi family
SMD44_RS02340	COG3395	kinase activity
SMD44_RS02345	COG0235	Class ii aldolase
SMD44_RS02375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMD44_RS02420	COG0697	spore germination
SMD44_RS02465	COG0789	Transcriptional regulator
SMD44_RS02480	COG0477	Major facilitator Superfamily
SMD44_RS02485	COG1957	nucleoside hydrolase
SMD44_RS02490	COG1609	Transcriptional regulator
SMD44_RS02500	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SMD44_RS02505	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
SMD44_RS02525	COG1131	(ABC) transporter
SMD44_RS02530	COG2259	Doxx family
SMD44_RS02545	COG2124	cytochrome p450
SMD44_RS02620	COG2197	response regulator
SMD44_RS02625	COG4585	Histidine kinase
SMD44_RS02630	COG0789	Transcriptional regulator
SMD44_RS02640	COG1335	isochorismatase
SMD44_RS02645	COG1349	DNA-binding transcription factor activity
SMD44_RS02655	COG0191	fructose-bisphosphate aldolase activity
SMD44_RS02690	COG1132	(ABC) transporter
SMD44_RS02705	COG2267	carboxylic ester hydrolase activity
SMD44_RS02710	COG1940	carbohydrate kinase activity
SMD44_RS02715	COG2182	Extracellular solute-binding protein
SMD44_RS02720	COG1175	transmembrane transport
SMD44_RS02725	COG0395	ABC-type sugar transport system, permease component
SMD44_RS02730	COG2723	6-phospho-beta-galactosidase activity
SMD44_RS02770	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS02775	COG3938	Belongs to the proline racemase family
SMD44_RS02810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMD44_RS02815	COG0601	transmembrane transport
SMD44_RS02825	COG4608	Belongs to the ABC transporter superfamily
SMD44_RS02830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMD44_RS02835	COG0667	Aldo Keto reductase
SMD44_RS02840	COG2814	Major facilitator Superfamily
SMD44_RS02850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD44_RS02865	COG3973	AAA domain
SMD44_RS02895	COG1309	transcriptional regulator
SMD44_RS02910	COG0435	Glutathione S-transferase
SMD44_RS02920	COG0789	Transcriptional regulator
SMD44_RS02940	COG2706	6-phosphogluconolactonase activity
SMD44_RS02955	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SMD44_RS02985	COG0386	Belongs to the glutathione peroxidase family
SMD44_RS02995	COG2223	nitrite transmembrane transporter activity
SMD44_RS03010	COG0673	inositol 2-dehydrogenase activity
SMD44_RS03015	COG2375	cellular response to nickel ion
SMD44_RS03015	COG1132	(ABC) transporter
SMD44_RS03030	COG0825	malonyl-CoA metabolic process
SMD44_RS03030	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SMD44_RS03035	COG1793	dna ligase
SMD44_RS03065	COG0181	hydroxymethylbilane synthase activity
SMD44_RS03070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD44_RS03095	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SMD44_RS03100	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SMD44_RS03105	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SMD44_RS03110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMD44_RS03115	COG2197	response regulator
SMD44_RS03120	COG1733	regulation of RNA biosynthetic process
SMD44_RS03130	COG1131	(ABC) transporter
SMD44_RS03140	COG4585	Histidine kinase
SMD44_RS03190	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMD44_RS03195	COG1129	ABC transporter
SMD44_RS03200	COG1940	carbohydrate kinase activity
SMD44_RS03200	COG1846	Transcriptional regulator
SMD44_RS03240	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SMD44_RS03245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMD44_RS03260	COG2124	cytochrome p450
SMD44_RS03290	COG1357	PFAM Pentapeptide repeats (8 copies)
SMD44_RS03325	COG3486	L-lysine 6-monooxygenase (NADPH) activity
SMD44_RS03330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMD44_RS03330	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SMD44_RS03370	COG1024	Enoyl-CoA hydratase
SMD44_RS03400	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS03415	COG0583	DNA-binding transcription factor activity
SMD44_RS03420	COG0318	PFAM AMP-dependent synthetase and ligase
SMD44_RS03425	COG2366	antibiotic biosynthetic process
SMD44_RS03435	COG2070	2-Nitropropane dioxygenase
SMD44_RS03445	COG4948	Mandelate Racemase Muconate Lactonizing
SMD44_RS03450	COG1414	Transcriptional regulator
SMD44_RS03475	COG0515	serine threonine protein kinase
SMD44_RS03520	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS03535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMD44_RS03600	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SMD44_RS03620	COG1131	(ABC) transporter
SMD44_RS03655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMD44_RS03660	COG0747	negative chemotaxis
SMD44_RS03665	COG0601	transmembrane transport
SMD44_RS03670	COG0444	Belongs to the ABC transporter superfamily
SMD44_RS03675	COG4608	Belongs to the ABC transporter superfamily
SMD44_RS03685	COG1595	DNA-templated transcription, initiation
SMD44_RS03710	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMD44_RS03740	COG2376	Dihydroxyacetone kinase
SMD44_RS03745	COG1461	Dihydroxyacetone kinase
SMD44_RS03775	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS03845	COG1902	pentaerythritol trinitrate reductase activity
SMD44_RS03845	COG0446	pyridine nucleotide-disulphide oxidoreductase
SMD44_RS03860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMD44_RS03885	COG2813	Specifically methylates the guanine in position
SMD44_RS03955	COG1349	DNA-binding transcription factor activity
SMD44_RS03980	COG0577	efflux transmembrane transporter activity
SMD44_RS03985	COG1136	(ABC) transporter
SMD44_RS04030	COG1940	carbohydrate kinase activity
SMD44_RS04060	COG4249	Peptidase C14 caspase catalytic subunit p20
SMD44_RS04060	COG2319	Wd-40 repeat
SMD44_RS04085	COG2197	response regulator
SMD44_RS04090	COG4585	Histidine kinase
SMD44_RS04095	COG0445	tRNA wobble uridine modification
SMD44_RS04110	COG2197	response regulator
SMD44_RS04115	COG4585	Histidine kinase
SMD44_RS04130	COG1660	Displays ATPase and GTPase activities
SMD44_RS04145	COG4585	Histidine kinase
SMD44_RS04150	COG2197	response regulator
SMD44_RS04280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMD44_RS04285	COG0438	transferase activity, transferring glycosyl groups
SMD44_RS04595	COG0305	Participates in initiation and elongation during chromosome replication
SMD44_RS04600	COG1484	DNA-dependent DNA replication
SMD44_RS04635	COG3723	Recombinational DNA repair protein, rece pathway
SMD44_RS04700	COG3617	BRO family, N-terminal domain
SMD44_RS04725	COG0395	ABC-type sugar transport system, permease component
SMD44_RS04740	COG3345	alpha-galactosidase
SMD44_RS04745	COG3903	Transcriptional regulator
SMD44_RS04745	COG3629	intracellular signal transduction
SMD44_RS04785	COG0515	serine threonine protein kinase
SMD44_RS04800	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SMD44_RS04820	COG0204	Acyl-transferase
SMD44_RS04855	COG0657	acetylesterase activity
SMD44_RS04860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD44_RS04875	COG0584	glycerophosphoryl diester phosphodiesterase
SMD44_RS04910	COG0671	phosphoesterase, PA-phosphatase related
SMD44_RS04925	COG1309	transcriptional regulator
SMD44_RS04940	COG2964	Protein conserved in bacteria
SMD44_RS04955	COG2186	Transcriptional regulator
SMD44_RS04960	COG2807	transmembrane transport
SMD44_RS04980	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SMD44_RS05005	COG0745	RESPONSE REGULATOR receiver
SMD44_RS05020	COG4941	Belongs to the sigma-70 factor family
SMD44_RS05075	COG0277	FAD linked oxidase domain protein
SMD44_RS05075	COG0247	lactate metabolic process
SMD44_RS05080	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SMD44_RS05085	COG1414	Transcriptional regulator
SMD44_RS05105	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS05150	COG2409	Drug exporters of the RND superfamily
SMD44_RS05165	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SMD44_RS05175	COG2890	protein-(glutamine-N5) methyltransferase activity
SMD44_RS05205	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SMD44_RS05210	COG1937	Protein conserved in bacteria
SMD44_RS05225	COG0277	FAD linked oxidase domain protein
SMD44_RS05245	COG0366	Alpha amylase catalytic
SMD44_RS05250	COG3833	ABC-type maltose transport systems, permease component
SMD44_RS05260	COG2182	Extracellular solute-binding protein
SMD44_RS05265	COG1609	Transcriptional regulator
SMD44_RS05270	COG0640	Transcriptional regulator
SMD44_RS05275	COG1116	anion transmembrane transporter activity
SMD44_RS05295	COG3384	dioxygenase
SMD44_RS05335	COG0330	HflC and HflK could
SMD44_RS05375	COG2084	Dehydrogenase
SMD44_RS05380	COG3629	intracellular signal transduction
SMD44_RS05380	COG3903	Transcriptional regulator
SMD44_RS05405	COG2175	clavaminate synthase activity
SMD44_RS05445	COG0515	serine threonine protein kinase
SMD44_RS05445	COG2815	serine threonine protein kinase
SMD44_RS05460	COG4941	Belongs to the sigma-70 factor family
SMD44_RS05475	COG0367	asparagine synthase
SMD44_RS05485	COG0697	spore germination
SMD44_RS05505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMD44_RS05515	COG2860	membrane
SMD44_RS05530	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS05540	COG0242	peptide deformylase activity
SMD44_RS05550	COG3442	glutamine amidotransferase
SMD44_RS05555	COG0205	6-phosphofructokinase activity
SMD44_RS05570	COG0204	Acyl-transferase
SMD44_RS05580	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SMD44_RS05680	COG0829	nickel cation binding
SMD44_RS05685	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SMD44_RS05695	COG0804	urea catabolic process
SMD44_RS05700	COG0832	Belongs to the urease beta subunit family
SMD44_RS05705	COG0831	urea catabolic process
SMD44_RS05710	COG1309	transcriptional regulator
SMD44_RS05725	COG0740	serine-type endopeptidase activity
SMD44_RS05745	COG1280	lysine exporter protein (LysE YggA)
SMD44_RS05770	COG0156	8-amino-7-oxononanoate synthase activity
SMD44_RS05775	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SMD44_RS05780	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SMD44_RS05785	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SMD44_RS05790	COG2226	methyltransferase
SMD44_RS05810	COG1136	(ABC) transporter
SMD44_RS05810	COG0577	efflux transmembrane transporter activity
SMD44_RS05815	COG0577	efflux transmembrane transporter activity
SMD44_RS05815	COG1136	(ABC) transporter
SMD44_RS05820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD44_RS05840	COG0583	DNA-binding transcription factor activity
SMD44_RS05875	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SMD44_RS05880	COG0586	Pfam SNARE associated Golgi protein
SMD44_RS05885	COG4585	Histidine kinase
SMD44_RS05910	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SMD44_RS05940	COG1024	Enoyl-CoA hydratase
SMD44_RS05960	COG4585	Histidine kinase
SMD44_RS05965	COG2197	response regulator
SMD44_RS05970	COG1940	carbohydrate kinase activity
SMD44_RS05975	COG2188	Transcriptional regulator
SMD44_RS05980	COG1595	DNA-templated transcription, initiation
SMD44_RS06005	COG1309	transcriptional regulator
SMD44_RS06015	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS06030	COG1522	sequence-specific DNA binding
SMD44_RS06035	COG0419	ATPase involved in DNA repair
SMD44_RS06040	COG0420	3'-5' exonuclease activity
SMD44_RS06070	COG1739	Uncharacterized protein family UPF0029
SMD44_RS06105	COG1832	CoA-binding protein
SMD44_RS06130	COG2205	protein histidine kinase activity
SMD44_RS06135	COG0745	RESPONSE REGULATOR receiver
SMD44_RS06190	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SMD44_RS06210	COG0110	maltose O-acetyltransferase activity
SMD44_RS06235	COG2272	Belongs to the type-B carboxylesterase lipase family
SMD44_RS06280	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SMD44_RS06295	COG1968	undecaprenyl-diphosphatase activity
SMD44_RS06340	COG1309	transcriptional regulator
SMD44_RS06345	COG0477	Major facilitator Superfamily
SMD44_RS06360	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SMD44_RS06365	COG0673	inositol 2-dehydrogenase activity
SMD44_RS06390	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SMD44_RS06395	COG0747	negative chemotaxis
SMD44_RS06445	COG0697	spore germination
SMD44_RS06485	COG2890	protein-(glutamine-N5) methyltransferase activity
SMD44_RS06500	COG0384	phenazine biosynthesis protein PhzF
SMD44_RS06530	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SMD44_RS06530	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SMD44_RS06540	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SMD44_RS06580	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SMD44_RS06615	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SMD44_RS06625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMD44_RS06640	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SMD44_RS06655	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SMD44_RS06660	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SMD44_RS06695	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SMD44_RS06710	COG1414	Transcriptional regulator
SMD44_RS06725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMD44_RS06755	COG2814	Major facilitator Superfamily
SMD44_RS06760	COG4336	lyase activity
SMD44_RS06765	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SMD44_RS06770	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SMD44_RS06775	COG1984	allophanate hydrolase subunit 2
SMD44_RS06785	COG0438	transferase activity, transferring glycosyl groups
SMD44_RS06815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMD44_RS06820	COG2364	Membrane
SMD44_RS06835	COG3030	protein affecting phage T7 exclusion by the F plasmid
SMD44_RS06840	COG0463	Glycosyl transferase, family 2
SMD44_RS06875	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS06885	COG1309	transcriptional regulator
SMD44_RS06940	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SMD44_RS06945	COG0140	phosphoribosyl-ATP diphosphatase activity
SMD44_RS06950	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SMD44_RS06955	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SMD44_RS06955	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SMD44_RS06960	COG3201	nicotinamide mononucleotide transporter
SMD44_RS06980	COG1940	carbohydrate kinase activity
SMD44_RS06980	COG1846	Transcriptional regulator
SMD44_RS06985	COG0738	Major facilitator superfamily
SMD44_RS06995	COG2233	PERMEase
SMD44_RS07015	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMD44_RS07030	COG0531	amino acid
SMD44_RS07035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD44_RS07055	COG2124	cytochrome p450
SMD44_RS07070	COG2124	cytochrome p450
SMD44_RS07090	COG2390	Transcriptional regulator
SMD44_RS07095	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SMD44_RS07100	COG2409	Drug exporters of the RND superfamily
SMD44_RS07105	COG4941	Belongs to the sigma-70 factor family
SMD44_RS07110	COG3795	YCII-related domain
SMD44_RS07130	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SMD44_RS07140	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SMD44_RS07145	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SMD44_RS07160	COG0194	GDP metabolic process
SMD44_RS07170	COG0284	orotidine-5'-phosphate decarboxylase activity
SMD44_RS07175	COG0167	dihydroorotate dehydrogenase activity
SMD44_RS07180	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SMD44_RS07185	COG0505	Belongs to the CarA family
SMD44_RS07195	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SMD44_RS07200	COG0540	Belongs to the ATCase OTCase family
SMD44_RS07205	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SMD44_RS07215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMD44_RS07220	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SMD44_RS07225	COG0006	proline dipeptidase activity
SMD44_RS07240	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SMD44_RS07245	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SMD44_RS07250	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SMD44_RS07255	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SMD44_RS07260	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SMD44_RS07265	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SMD44_RS07270	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SMD44_RS07290	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SMD44_RS07315	COG4585	Histidine kinase
SMD44_RS07320	COG2197	response regulator
SMD44_RS07325	COG0124	histidyl-tRNA synthetase
SMD44_RS07335	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SMD44_RS07340	COG1196	nuclear chromosome segregation
SMD44_RS07345	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SMD44_RS07355	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SMD44_RS07360	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SMD44_RS07370	COG2255	four-way junction helicase activity
SMD44_RS07375	COG0632	four-way junction helicase activity
SMD44_RS07380	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SMD44_RS07385	COG0217	transcriptional regulatory protein
SMD44_RS07390	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SMD44_RS07395	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SMD44_RS07410	COG0438	transferase activity, transferring glycosyl groups
SMD44_RS07415	COG1560	Kdo2-lipid A biosynthetic process
SMD44_RS07420	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SMD44_RS07445	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SMD44_RS07460	COG2176	DNA-directed DNA polymerase activity
SMD44_RS07460	COG5002	protein histidine kinase activity
SMD44_RS07520	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SMD44_RS07580	COG1648	precorrin-2 dehydrogenase activity
SMD44_RS07580	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SMD44_RS07585	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SMD44_RS07600	COG1464	Belongs to the NlpA lipoprotein family
SMD44_RS07605	COG1464	Belongs to the NlpA lipoprotein family
SMD44_RS07610	COG2011	ABC-type metal ion transport system permease component
SMD44_RS07615	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SMD44_RS07645	COG0584	glycerophosphoryl diester phosphodiesterase
SMD44_RS07650	COG0318	PFAM AMP-dependent synthetase and ligase
SMD44_RS07650	COG0204	Acyl-transferase
SMD44_RS07655	COG0477	Major facilitator Superfamily
SMD44_RS07670	COG0165	Argininosuccinate lyase
SMD44_RS07675	COG0137	argininosuccinate synthase activity
SMD44_RS07685	COG0326	Molecular chaperone. Has ATPase activity
SMD44_RS07700	COG0385	Bile acid
SMD44_RS07705	COG0326	Molecular chaperone. Has ATPase activity
SMD44_RS07710	COG1438	arginine binding
SMD44_RS07715	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMD44_RS07720	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SMD44_RS07725	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SMD44_RS07730	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SMD44_RS07735	COG2838	Isocitrate dehydrogenase
SMD44_RS07740	COG0789	Transcriptional regulator
SMD44_RS07755	COG0667	Aldo Keto reductase
SMD44_RS07780	COG0697	spore germination
SMD44_RS07790	COG1649	PFAM Uncharacterised BCR, COG1649
SMD44_RS07820	COG0072	phenylalanine-tRNA ligase activity
SMD44_RS07820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMD44_RS07825	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SMD44_RS07830	COG5002	protein histidine kinase activity
SMD44_RS07835	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SMD44_RS07840	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SMD44_RS07845	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SMD44_RS07850	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SMD44_RS07890	COG3830	Belongs to the UPF0237 family
SMD44_RS07890	COG0560	Phosphoserine phosphatase
SMD44_RS07900	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS07905	COG0174	glutamine synthetase
SMD44_RS07915	COG0531	amino acid
SMD44_RS07920	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SMD44_RS07935	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SMD44_RS07945	COG4176	ABC-type proline glycine betaine transport system permease component
SMD44_RS07950	COG4175	Glycine betaine
SMD44_RS07950	COG0517	IMP dehydrogenase activity
SMD44_RS07955	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMD44_RS07970	COG0564	pseudouridine synthase activity
SMD44_RS08010	COG0805	protein transport
SMD44_RS08015	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SMD44_RS08050	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SMD44_RS08060	COG1609	Transcriptional regulator
SMD44_RS08065	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SMD44_RS08070	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SMD44_RS08085	COG4122	O-methyltransferase activity
SMD44_RS08090	COG1222	aaa ATPase
SMD44_RS08115	COG0517	IMP dehydrogenase activity
SMD44_RS08115	COG1994	Peptidase M50
SMD44_RS08125	COG2197	response regulator
SMD44_RS08130	COG4166	transmembrane transport
SMD44_RS08135	COG0747	negative chemotaxis
SMD44_RS08140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMD44_RS08145	COG1410	methionine synthase
SMD44_RS08145	COG0646	methionine synthase
SMD44_RS08150	COG1414	Transcriptional regulator
SMD44_RS08155	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SMD44_RS08160	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SMD44_RS08165	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SMD44_RS08175	COG0402	S-adenosylhomocysteine deaminase activity
SMD44_RS08180	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SMD44_RS08190	COG2186	Transcriptional regulator
SMD44_RS08210	COG0215	cysteine-tRNA ligase activity
SMD44_RS08225	COG0406	alpha-ribazole phosphatase activity
SMD44_RS08230	COG0598	Magnesium transport protein CorA
SMD44_RS08240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD44_RS08245	COG0667	Aldo Keto reductase
SMD44_RS08280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMD44_RS08345	COG0753	catalase activity
SMD44_RS08350	COG3012	SEC-C Motif Domain Protein
SMD44_RS08365	COG3265	gluconokinase activity
SMD44_RS08380	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SMD44_RS08395	COG3573	Dehydrogenase
SMD44_RS08400	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SMD44_RS08405	COG2149	membrane
SMD44_RS08430	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS08440	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS08485	COG0789	Transcriptional regulator
SMD44_RS08500	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS08530	COG2851	Citrate transporter
SMD44_RS08535	COG0243	molybdopterin cofactor binding
SMD44_RS08545	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
SMD44_RS08550	COG2188	Transcriptional regulator
SMD44_RS08560	COG0477	Major facilitator Superfamily
SMD44_RS08575	COG2197	response regulator
SMD44_RS08585	COG5343	regulation of RNA biosynthetic process
SMD44_RS08590	COG1595	DNA-templated transcription, initiation
SMD44_RS08615	COG2755	lipolytic protein G-D-S-L family
SMD44_RS08630	COG0463	Glycosyl transferase, family 2
SMD44_RS08635	COG1442	glycosyl transferase family 8
SMD44_RS08635	COG1216	Glycosyl transferase, family 2
SMD44_RS08660	COG1725	Transcriptional regulator
SMD44_RS08705	COG4565	transcriptional regulatory protein
SMD44_RS08715	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
SMD44_RS08735	COG0587	DNA-directed DNA polymerase activity
SMD44_RS08750	COG2197	response regulator
SMD44_RS08755	COG4585	Histidine kinase
SMD44_RS08760	COG2409	Drug exporters of the RND superfamily
SMD44_RS08775	COG1454	alcohol dehydrogenase
SMD44_RS08775	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS08790	COG3227	Zinc metalloprotease (Elastase)
SMD44_RS08805	COG4166	transmembrane transport
SMD44_RS08810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMD44_RS08835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD44_RS08845	COG0765	amino acid transport
SMD44_RS08850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMD44_RS08860	COG1799	cell septum assembly
SMD44_RS08865	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS08870	COG0477	Major facilitator Superfamily
SMD44_RS08880	COG0671	phosphoesterase, PA-phosphatase related
SMD44_RS08890	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SMD44_RS08900	COG0438	transferase activity, transferring glycosyl groups
SMD44_RS08930	COG3583	domain protein
SMD44_RS08935	COG1652	LysM domain
SMD44_RS08950	COG1160	GTP binding
SMD44_RS08960	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SMD44_RS09000	COG3541	Predicted nucleotidyltransferase
SMD44_RS09005	COG1187	pseudouridine synthase activity
SMD44_RS09010	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SMD44_RS09015	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SMD44_RS09030	COG0686	Belongs to the AlaDH PNT family
SMD44_RS09040	COG0494	nUDIX hydrolase
SMD44_RS09045	COG0504	CTP synthase activity
SMD44_RS09050	COG3387	PFAM Glycoside hydrolase 15-related
SMD44_RS09060	COG0438	transferase activity, transferring glycosyl groups
SMD44_RS09070	COG0497	DNA recombination
SMD44_RS09080	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SMD44_RS09100	COG1120	ATPase activity
SMD44_RS09105	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD44_RS09110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD44_RS09130	COG0647	UMP catabolic process
SMD44_RS09170	COG2094	Belongs to the DNA glycosylase MPG family
SMD44_RS09180	COG1881	PFAM PEBP family protein
SMD44_RS09200	COG1119	ATPase activity
SMD44_RS09220	COG2197	response regulator
SMD44_RS09235	COG0842	Transport permease protein
SMD44_RS09235	COG1131	(ABC) transporter
SMD44_RS09235	COG1716	ATPase activity
SMD44_RS09245	COG0560	Phosphoserine phosphatase
SMD44_RS09245	COG3830	Belongs to the UPF0237 family
SMD44_RS09270	COG2186	Transcriptional regulator
SMD44_RS09285	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS09300	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SMD44_RS09320	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SMD44_RS09325	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SMD44_RS09335	COG1404	Belongs to the peptidase S8 family
SMD44_RS09340	COG1404	Belongs to the peptidase S8 family
SMD44_RS09400	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SMD44_RS09415	COG3387	PFAM Glycoside hydrolase 15-related
SMD44_RS09465	COG0488	(ABC) transporter
SMD44_RS09490	COG0235	Class ii aldolase
SMD44_RS09520	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SMD44_RS09540	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SMD44_RS09545	COG1797	cobyrinic acid a,c-diamide synthase activity
SMD44_RS09595	COG3119	arylsulfatase activity
SMD44_RS09605	COG1104	cysteine desulfurase activity
SMD44_RS09610	COG0456	acetyltransferase
SMD44_RS09615	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SMD44_RS09620	COG1917	Cupin 2, conserved barrel domain protein
SMD44_RS09625	COG5285	phytanoyl-CoA dioxygenase
SMD44_RS09630	COG1902	pentaerythritol trinitrate reductase activity
SMD44_RS09635	COG1846	Transcriptional regulator
SMD44_RS09640	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SMD44_RS09650	COG1733	regulation of RNA biosynthetic process
SMD44_RS09670	COG1414	Transcriptional regulator
SMD44_RS09680	COG4585	Histidine kinase
SMD44_RS09685	COG2197	response regulator
SMD44_RS09690	COG0768	penicillin binding
SMD44_RS09700	COG1695	Transcriptional regulator
SMD44_RS09740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMD44_RS09745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMD44_RS09755	COG1349	DNA-binding transcription factor activity
SMD44_RS09770	COG0395	ABC-type sugar transport system, permease component
SMD44_RS09775	COG1063	alcohol dehydrogenase
SMD44_RS09810	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS09845	COG2329	Antibiotic biosynthesis monooxygenase
SMD44_RS09855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMD44_RS09865	COG1595	DNA-templated transcription, initiation
SMD44_RS09875	COG2171	N-acyltransferase activity
SMD44_RS09890	COG3226	Transcriptional regulator
SMD44_RS09895	COG2076	Multidrug Resistance protein
SMD44_RS09905	COG0822	iron-sulfur transferase activity
SMD44_RS09910	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SMD44_RS09915	COG0396	ATPase activity
SMD44_RS09925	COG0719	Fe-S assembly protein
SMD44_RS09940	COG2746	aminoglycoside 3-N-acetyltransferase activity
SMD44_RS09945	COG1131	(ABC) transporter
SMD44_RS09955	COG1612	heme a metabolic process
SMD44_RS09975	COG0109	protoheme IX farnesyltransferase activity
SMD44_RS09985	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SMD44_RS10000	COG0363	glucosamine-6-phosphate deaminase activity
SMD44_RS10010	COG0166	Belongs to the GPI family
SMD44_RS10025	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SMD44_RS10030	COG0149	triose-phosphate isomerase activity
SMD44_RS10035	COG0126	phosphoglycerate kinase activity
SMD44_RS10040	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SMD44_RS10050	COG1481	regulation of sporulation
SMD44_RS10055	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SMD44_RS10060	COG1660	Displays ATPase and GTPase activities
SMD44_RS10065	COG0322	excinuclease ABC activity
SMD44_RS10100	COG2353	YceI-like domain
SMD44_RS10105	COG1024	Enoyl-CoA hydratase
SMD44_RS10110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SMD44_RS10125	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SMD44_RS10130	COG1619	proteins homologs of microcin C7 resistance protein MccF
SMD44_RS10135	COG0477	Major facilitator Superfamily
SMD44_RS10140	COG0387	Pfam Sodium calcium exchanger
SMD44_RS10170	COG0584	glycerophosphoryl diester phosphodiesterase
SMD44_RS10175	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMD44_RS10190	COG2313	pseudouridylate synthase activity
SMD44_RS10195	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SMD44_RS10195	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SMD44_RS10200	COG2226	methyltransferase
SMD44_RS10205	COG0598	Magnesium transport protein CorA
SMD44_RS10270	COG2124	cytochrome p450
SMD44_RS10275	COG0402	S-adenosylhomocysteine deaminase activity
SMD44_RS10310	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SMD44_RS10350	COG2267	carboxylic ester hydrolase activity
SMD44_RS10355	COG1288	antiporter activity
SMD44_RS10390	COG0237	dephospho-CoA kinase activity
SMD44_RS10410	COG2226	methyltransferase
SMD44_RS10415	COG1643	Atp-dependent helicase
SMD44_RS10440	COG2050	protein possibly involved in aromatic compounds catabolism
SMD44_RS10450	COG0559	Belongs to the binding-protein-dependent transport system permease family
SMD44_RS10490	COG0737	Belongs to the 5'-nucleotidase family
SMD44_RS10520	COG0287	Prephenate dehydrogenase
SMD44_RS10520	COG1605	Chorismate mutase
SMD44_RS10535	COG1470	cell adhesion involved in biofilm formation
SMD44_RS10535	COG0366	Alpha amylase catalytic
SMD44_RS10540	COG3851	Histidine kinase
SMD44_RS10545	COG2197	response regulator
SMD44_RS10560	COG0513	Belongs to the DEAD box helicase family
SMD44_RS10565	COG1278	Cold shock
SMD44_RS10570	COG0477	Major facilitator Superfamily
SMD44_RS10575	COG1846	Transcriptional regulator
SMD44_RS10580	COG2365	Tyrosine phosphatase family
SMD44_RS10590	COG2267	carboxylic ester hydrolase activity
SMD44_RS10605	COG0395	ABC-type sugar transport system, permease component
SMD44_RS10610	COG1175	transmembrane transport
SMD44_RS10625	COG0070	glutamate synthase
SMD44_RS10625	COG0067	glutamate synthase
SMD44_RS10625	COG0069	glutamate synthase activity
SMD44_RS10655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMD44_RS10660	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SMD44_RS10670	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SMD44_RS10680	COG0159	tryptophan synthase activity
SMD44_RS10685	COG0133	tryptophan synthase activity
SMD44_RS10695	COG0134	indole-3-glycerol-phosphate synthase activity
SMD44_RS10720	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SMD44_RS10745	COG0107	imidazoleglycerol-phosphate synthase activity
SMD44_RS10750	COG0251	oxidation-reduction process
SMD44_RS10755	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SMD44_RS10760	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SMD44_RS10765	COG0131	Imidazoleglycerol-phosphate dehydratase
SMD44_RS10770	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMD44_RS10775	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SMD44_RS10795	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SMD44_RS10815	COG1432	Conserved Protein
SMD44_RS10825	COG0587	DNA-directed DNA polymerase activity
SMD44_RS10850	COG0515	serine threonine protein kinase
SMD44_RS10880	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SMD44_RS10900	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SMD44_RS10915	COG1799	cell septum assembly
SMD44_RS10925	COG1496	oxidoreductase activity
SMD44_RS10930	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SMD44_RS10945	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SMD44_RS10955	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SMD44_RS10960	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMD44_RS10970	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SMD44_RS10985	COG0275	rRNA processing
SMD44_RS10995	COG0714	Associated with various cellular activities
SMD44_RS11015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SMD44_RS11025	COG0842	Transport permease protein
SMD44_RS11025	COG1716	ATPase activity
SMD44_RS11025	COG1131	(ABC) transporter
SMD44_RS11035	COG1309	transcriptional regulator
SMD44_RS11060	COG0352	thiamine-phosphate diphosphorylase activity
SMD44_RS11075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMD44_RS11075	COG2022	thiamine diphosphate biosynthetic process
SMD44_RS11085	COG2022	thiamine diphosphate biosynthetic process
SMD44_RS11090	COG0515	serine threonine protein kinase
SMD44_RS11090	COG2815	serine threonine protein kinase
SMD44_RS11095	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SMD44_RS11100	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SMD44_RS11105	COG2193	ferroxidase activity
SMD44_RS11110	COG0243	molybdopterin cofactor binding
SMD44_RS11115	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SMD44_RS11135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SMD44_RS11140	COG0205	6-phosphofructokinase activity
SMD44_RS11145	COG2197	response regulator
SMD44_RS11150	COG4585	Histidine kinase
SMD44_RS11175	COG1940	carbohydrate kinase activity
SMD44_RS11185	COG0003	Pfam Anion-transporting ATPase
SMD44_RS11205	COG0438	transferase activity, transferring glycosyl groups
SMD44_RS11255	COG2205	protein histidine kinase activity
SMD44_RS11260	COG0745	RESPONSE REGULATOR receiver
SMD44_RS11270	COG1929	Belongs to the glycerate kinase type-1 family
SMD44_RS11275	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SMD44_RS11280	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SMD44_RS11285	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SMD44_RS11290	COG0723	plastoquinol--plastocyanin reductase activity
SMD44_RS11295	COG2010	Cytochrome c
SMD44_RS11300	COG1845	cytochrome c oxidase, subunit III
SMD44_RS11310	COG1376	ErfK ybiS ycfS ynhG family protein
SMD44_RS11320	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SMD44_RS11325	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SMD44_RS11330	COG1104	cysteine desulfurase activity
SMD44_RS11335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMD44_RS11355	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SMD44_RS11360	COG2197	response regulator
SMD44_RS11365	COG4585	Histidine kinase
SMD44_RS11390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMD44_RS11410	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SMD44_RS11415	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SMD44_RS11415	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SMD44_RS11430	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SMD44_RS11435	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SMD44_RS11440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SMD44_RS11445	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMD44_RS11455	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SMD44_RS11475	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS11515	COG0321	lipoyl(octanoyl) transferase activity
SMD44_RS11520	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SMD44_RS11545	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
SMD44_RS11570	COG0590	tRNA wobble adenosine to inosine editing
SMD44_RS11590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SMD44_RS11595	COG0640	Transcriptional regulator
SMD44_RS11600	COG2226	methyltransferase
SMD44_RS11620	COG1120	ATPase activity
SMD44_RS11625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD44_RS11680	COG0745	RESPONSE REGULATOR receiver
SMD44_RS11690	COG2409	Drug exporters of the RND superfamily
SMD44_RS11695	COG4585	Histidine kinase
SMD44_RS11700	COG2197	response regulator
SMD44_RS11740	COG1309	transcriptional regulator
SMD44_RS11750	COG0366	Alpha amylase catalytic
SMD44_RS11755	COG1609	Transcriptional regulator
SMD44_RS11765	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SMD44_RS11780	COG0174	glutamine synthetase
SMD44_RS11805	COG4209	transmembrane transport
SMD44_RS11810	COG0395	ABC-type sugar transport system, permease component
SMD44_RS11820	COG1609	Transcriptional regulator
SMD44_RS11835	COG0531	amino acid
SMD44_RS11845	COG2132	Multicopper oxidase
SMD44_RS11850	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SMD44_RS11850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMD44_RS11855	COG2814	Major facilitator Superfamily
SMD44_RS11870	COG0477	Major facilitator Superfamily
SMD44_RS11875	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SMD44_RS11895	COG1994	Peptidase M50
SMD44_RS11955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SMD44_RS11960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD44_RS11965	COG1120	ATPase activity
SMD44_RS11990	COG1834	amidinotransferase
SMD44_RS12000	COG2814	Major facilitator Superfamily
SMD44_RS12015	COG3540	Alkaline phosphatase
SMD44_RS12020	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS12030	COG0384	phenazine biosynthesis protein PhzF
SMD44_RS12085	COG0475	glutathione-regulated potassium exporter activity
SMD44_RS12120	COG0557	exoribonuclease II activity
SMD44_RS12125	COG3022	response to hydroperoxide
SMD44_RS12130	COG0800	Aldolase
SMD44_RS12145	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SMD44_RS12150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SMD44_RS12160	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS12170	COG2030	dehydratase
SMD44_RS12175	COG4585	Histidine kinase
SMD44_RS12180	COG2197	response regulator
SMD44_RS12190	COG0183	Belongs to the thiolase family
SMD44_RS12215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD44_RS12265	COG0438	transferase activity, transferring glycosyl groups
SMD44_RS12270	COG1309	transcriptional regulator
SMD44_RS12320	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS12325	COG1657	PFAM Prenyltransferase squalene oxidase
SMD44_RS12340	COG3845	ABC transporter
SMD44_RS12355	COG0183	Belongs to the thiolase family
SMD44_RS12360	COG2124	cytochrome p450
SMD44_RS12380	COG4122	O-methyltransferase activity
SMD44_RS12490	COG4977	sequence-specific DNA binding
SMD44_RS12540	COG0800	Aldolase
SMD44_RS12560	COG1358	cellular component organization or biogenesis
SMD44_RS12610	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SMD44_RS12615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMD44_RS12635	COG0667	Aldo Keto reductase
SMD44_RS12640	COG0789	Transcriptional regulator
SMD44_RS12655	COG1741	Belongs to the pirin family
SMD44_RS12670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMD44_RS12675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMD44_RS12680	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMD44_RS12705	COG0583	DNA-binding transcription factor activity
SMD44_RS12725	COG1764	response to oxidative stress
SMD44_RS12730	COG2130	NADP-dependent
SMD44_RS12765	COG4981	capsule polysaccharide biosynthetic process
SMD44_RS12820	COG1215	transferase activity, transferring glycosyl groups
SMD44_RS12825	COG0318	PFAM AMP-dependent synthetase and ligase
SMD44_RS12840	COG0535	radical SAM domain protein
SMD44_RS12855	COG1404	Belongs to the peptidase S8 family
SMD44_RS12890	COG1077	Cell shape determining protein MreB Mrl
SMD44_RS12910	COG3585	molybdate ion transport
SMD44_RS12930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD44_RS12935	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SMD44_RS12975	COG0515	serine threonine protein kinase
SMD44_RS13000	COG1857	crispr-associated protein
SMD44_RS13115	COG1316	TRANSCRIPTIONal
SMD44_RS13140	COG3594	Acyltransferase
SMD44_RS13195	COG1070	Carbohydrate kinase
SMD44_RS13220	COG0358	DNA primase activity
SMD44_RS13230	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SMD44_RS13245	COG0243	molybdopterin cofactor binding
SMD44_RS13265	COG2205	protein histidine kinase activity
SMD44_RS13300	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SMD44_RS13305	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SMD44_RS13305	COG2146	nitrite reductase [NAD(P)H] activity
SMD44_RS13315	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS13330	COG0531	amino acid
SMD44_RS13360	COG0574	Belongs to the PEP-utilizing enzyme family
SMD44_RS13360	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SMD44_RS13365	COG1940	carbohydrate kinase activity
SMD44_RS13365	COG1846	Transcriptional regulator
SMD44_RS13370	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
SMD44_RS13390	COG0477	Major facilitator Superfamily
SMD44_RS13395	COG0477	Major facilitator Superfamily
SMD44_RS13400	COG0667	Aldo Keto reductase
SMD44_RS13420	COG0423	glycine-tRNA ligase activity
SMD44_RS13425	COG3443	Belongs to the bacterial solute-binding protein 9 family
SMD44_RS13425	COG0803	Belongs to the bacterial solute-binding protein 9 family
SMD44_RS13430	COG1121	(ABC) transporter
SMD44_RS13435	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SMD44_RS13445	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SMD44_RS13450	COG1381	Involved in DNA repair and RecF pathway recombination
SMD44_RS13495	COG3629	intracellular signal transduction
SMD44_RS13495	COG3903	Transcriptional regulator
SMD44_RS13505	COG3631	Ketosteroid isomerase-related protein
SMD44_RS13510	COG0702	epimerase
SMD44_RS13520	COG2186	Transcriptional regulator
SMD44_RS13525	COG0747	negative chemotaxis
SMD44_RS13535	COG0444	Belongs to the ABC transporter superfamily
SMD44_RS13540	COG4608	Belongs to the ABC transporter superfamily
SMD44_RS13545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMD44_RS13555	COG2197	response regulator
SMD44_RS13560	COG4585	Histidine kinase
SMD44_RS13565	COG2409	Drug exporters of the RND superfamily
SMD44_RS13575	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMD44_RS13595	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SMD44_RS13615	COG2315	Protein conserved in bacteria
SMD44_RS13625	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SMD44_RS13635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMD44_RS13640	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SMD44_RS13645	COG1234	tRNA 3'-trailer cleavage
SMD44_RS13650	COG0537	adenosine 5'-monophosphoramidase activity
SMD44_RS13655	COG0793	Belongs to the peptidase S41A family
SMD44_RS13655	COG4946	Tricorn protease homolog
SMD44_RS13675	COG2070	2-Nitropropane dioxygenase
SMD44_RS13680	COG0484	heat shock protein binding
SMD44_RS13685	COG1420	regulation of RNA biosynthetic process
SMD44_RS13710	COG2205	protein histidine kinase activity
SMD44_RS13710	COG3437	response regulator, receiver
SMD44_RS13710	COG4999	Histidine kinase
SMD44_RS13710	COG3850	Histidine kinase
SMD44_RS13725	COG0481	GTPase activity
SMD44_RS13730	COG0268	Binds directly to 16S ribosomal RNA
SMD44_RS13745	COG2353	YceI-like domain
SMD44_RS13755	COG1555	photosystem II stabilization
SMD44_RS13760	COG1307	EDD domain protein, DegV family
SMD44_RS13770	COG0495	leucyl-tRNA aminoacylation
SMD44_RS13780	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SMD44_RS13790	COG1051	belongs to the nudix hydrolase family
SMD44_RS13800	COG0477	Major facilitator Superfamily
SMD44_RS13815	COG0588	phosphoglycerate mutase activity
SMD44_RS13820	COG0799	negative regulation of ribosome biogenesis
SMD44_RS13830	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SMD44_RS13845	COG0501	Belongs to the peptidase M48B family
SMD44_RS13860	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SMD44_RS13870	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SMD44_RS13880	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SMD44_RS13885	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SMD44_RS13890	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SMD44_RS13900	COG1530	ribonuclease E activity
SMD44_RS13930	COG0772	Belongs to the SEDS family
SMD44_RS13950	COG1077	Cell shape determining protein MreB Mrl
SMD44_RS13955	COG0105	UTP biosynthetic process
SMD44_RS13965	COG0285	dihydrofolate synthase activity
SMD44_RS13970	COG1077	Cell shape determining protein MreB Mrl
SMD44_RS13980	COG4585	Histidine kinase
SMD44_RS13990	COG2205	protein histidine kinase activity
SMD44_RS14010	COG0525	valine-tRNA ligase activity
SMD44_RS14030	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SMD44_RS14035	COG0740	serine-type endopeptidase activity
SMD44_RS14040	COG0740	serine-type endopeptidase activity
SMD44_RS14045	COG0544	peptidyl-prolyl cis-trans isomerase activity
SMD44_RS14060	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMD44_RS14060	COG0515	serine threonine protein kinase
SMD44_RS14070	COG3594	Acyltransferase
SMD44_RS14085	COG0577	efflux transmembrane transporter activity
SMD44_RS14085	COG1136	(ABC) transporter
SMD44_RS14095	COG4552	Acetyltransferase involved in intracellular survival and related
SMD44_RS14115	COG1113	amino acid transport
SMD44_RS14125	COG1268	BioY protein
SMD44_RS14130	COG1113	amino acid transport
SMD44_RS14135	COG1113	amino acid transport
SMD44_RS14140	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SMD44_RS14145	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SMD44_RS14215	COG2814	Major facilitator Superfamily
SMD44_RS14220	COG0583	DNA-binding transcription factor activity
SMD44_RS14275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SMD44_RS14275	COG1116	anion transmembrane transporter activity
SMD44_RS14280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SMD44_RS14285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SMD44_RS14310	COG0697	spore germination
SMD44_RS14315	COG1846	Transcriptional regulator
SMD44_RS14340	COG0668	transmembrane transport
SMD44_RS14345	COG1940	carbohydrate kinase activity
SMD44_RS14345	COG1846	Transcriptional regulator
SMD44_RS14350	COG1653	transport
SMD44_RS14355	COG1175	transmembrane transport
SMD44_RS14360	COG0395	ABC-type sugar transport system, permease component
SMD44_RS14365	COG1486	melibiose metabolic process
SMD44_RS14380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMD44_RS14410	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SMD44_RS14435	COG0456	acetyltransferase
SMD44_RS14510	COG0629	single-stranded DNA binding
SMD44_RS14560	COG1022	Amp-dependent synthetase and ligase
SMD44_RS14565	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SMD44_RS14565	COG4106	trans-aconitate 2-methyltransferase activity
SMD44_RS14570	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SMD44_RS14585	COG1131	(ABC) transporter
SMD44_RS14590	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SMD44_RS14605	COG3962	Belongs to the TPP enzyme family
SMD44_RS14610	COG3718	enzyme involved in inositol metabolism
SMD44_RS14620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMD44_RS14625	COG1082	Xylose isomerase domain protein TIM barrel
SMD44_RS14655	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SMD44_RS14660	COG1609	Transcriptional regulator
SMD44_RS14665	COG1129	ABC transporter
SMD44_RS14670	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMD44_RS14675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMD44_RS14680	COG1869	D-ribose catabolic process
SMD44_RS14700	COG0673	inositol 2-dehydrogenase activity
SMD44_RS14705	COG1609	Transcriptional regulator
SMD44_RS14730	COG0456	acetyltransferase
SMD44_RS14730	COG1846	Transcriptional regulator
SMD44_RS14740	COG0789	Transcriptional regulator
SMD44_RS14755	COG1472	Belongs to the glycosyl hydrolase 3 family
SMD44_RS14785	COG0028	Belongs to the TPP enzyme family
SMD44_RS14795	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SMD44_RS14825	COG1946	Acyl-CoA thioesterase
SMD44_RS14835	COG1309	transcriptional regulator
SMD44_RS14840	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SMD44_RS14855	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS14870	COG3486	L-lysine 6-monooxygenase (NADPH) activity
SMD44_RS14900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMD44_RS14905	COG0589	response to stress
SMD44_RS14915	COG4977	sequence-specific DNA binding
SMD44_RS14920	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
SMD44_RS14995	COG0588	phosphoglycerate mutase activity
SMD44_RS15045	COG0583	DNA-binding transcription factor activity
SMD44_RS15050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD44_RS15070	COG0154	amidase activity
SMD44_RS15085	COG0765	amino acid transport
SMD44_RS15090	COG0765	amino acid transport
SMD44_RS15095	COG1126	abc transporter atp-binding protein
SMD44_RS15115	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SMD44_RS15125	COG0512	Glutamine amidotransferase of anthranilate synthase
SMD44_RS15135	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SMD44_RS15150	COG4585	Histidine kinase
SMD44_RS15155	COG2197	response regulator
SMD44_RS15160	COG2409	Drug exporters of the RND superfamily
SMD44_RS15170	COG2197	response regulator
SMD44_RS15175	COG4585	Histidine kinase
SMD44_RS15180	COG0318	PFAM AMP-dependent synthetase and ligase
SMD44_RS15185	COG3397	chitin binding
SMD44_RS15210	COG2186	Transcriptional regulator
SMD44_RS15290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMD44_RS15295	COG2188	Transcriptional regulator
SMD44_RS15310	COG0673	inositol 2-dehydrogenase activity
SMD44_RS15315	COG4702	Belongs to the UPF0303 family
SMD44_RS15325	COG0179	Fumarylacetoacetate (FAA) hydrolase
SMD44_RS15330	COG0706	membrane insertase activity
SMD44_RS15350	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SMD44_RS15360	COG3764	Sortase (surface protein transpeptidase)
SMD44_RS15420	COG4977	sequence-specific DNA binding
SMD44_RS15425	COG2271	Major facilitator Superfamily
SMD44_RS15430	COG2733	membrane
SMD44_RS15445	COG4555	ABC transporter
SMD44_RS15485	COG0477	Major facilitator Superfamily
SMD44_RS15495	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SMD44_RS15505	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SMD44_RS15510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMD44_RS15515	COG1263	PTS System
SMD44_RS15520	COG1263	PTS System
SMD44_RS15525	COG1234	tRNA 3'-trailer cleavage
SMD44_RS15545	COG1120	ATPase activity
SMD44_RS15550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD44_RS15565	COG1113	amino acid transport
SMD44_RS15570	COG1115	amino acid carrier protein
SMD44_RS15580	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SMD44_RS15590	COG1335	isochorismatase
SMD44_RS15625	COG0277	FAD linked oxidase domain protein
SMD44_RS15635	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SMD44_RS15645	COG1174	glycine betaine transport
SMD44_RS15655	COG1174	glycine betaine transport
SMD44_RS15785	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SMD44_RS15795	COG2814	Major facilitator Superfamily
SMD44_RS15800	COG0583	DNA-binding transcription factor activity
SMD44_RS15805	COG1678	Uncharacterized ACR, COG1678
SMD44_RS15810	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SMD44_RS15815	COG0776	regulation of translation
SMD44_RS15825	COG3973	AAA domain
SMD44_RS15855	COG2223	nitrite transmembrane transporter activity
SMD44_RS15905	COG0583	DNA-binding transcription factor activity
SMD44_RS15915	COG2027	D-alanyl-D-alanine carboxypeptidase
SMD44_RS15925	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SMD44_RS15930	COG0793	Belongs to the peptidase S41A family
SMD44_RS15940	COG2884	Cell division ATP-binding protein ftsE
SMD44_RS15955	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SMD44_RS15960	COG0515	serine threonine protein kinase
SMD44_RS15965	COG0515	serine threonine protein kinase
SMD44_RS15970	COG1674	ftsk spoiiie
SMD44_RS15980	COG1175	transmembrane transport
SMD44_RS15985	COG0395	ABC-type sugar transport system, permease component
SMD44_RS16000	COG0438	transferase activity, transferring glycosyl groups
SMD44_RS16005	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SMD44_RS16010	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SMD44_RS16020	COG1215	transferase activity, transferring glycosyl groups
SMD44_RS16035	COG1136	(ABC) transporter
SMD44_RS16045	COG2197	response regulator
SMD44_RS16065	COG1134	teichoic acid transport
SMD44_RS16070	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SMD44_RS16075	COG1215	transferase activity, transferring glycosyl groups
SMD44_RS16100	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SMD44_RS16115	COG1216	Glycosyl transferase, family 2
SMD44_RS16120	COG2902	Dehydrogenase
SMD44_RS16145	COG0653	protein targeting
SMD44_RS16155	COG3214	Protein conserved in bacteria
SMD44_RS16160	COG2197	response regulator
SMD44_RS16165	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SMD44_RS16175	COG0823	Involved in the tonB-independent uptake of proteins
SMD44_RS16180	COG5002	protein histidine kinase activity
SMD44_RS16185	COG0745	RESPONSE REGULATOR receiver
SMD44_RS16190	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SMD44_RS16210	COG0714	Associated with various cellular activities
SMD44_RS16255	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SMD44_RS16260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMD44_RS16260	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMD44_RS16260	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMD44_RS16270	COG1482	cell wall glycoprotein biosynthetic process
SMD44_RS16280	COG2835	tetraacyldisaccharide 4'-kinase activity
SMD44_RS16285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMD44_RS16290	COG1620	l-lactate permease
SMD44_RS16325	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SMD44_RS16330	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
SMD44_RS16330	COG0778	Nitroreductase
SMD44_RS16355	COG1316	TRANSCRIPTIONal
SMD44_RS16360	COG1316	TRANSCRIPTIONal
SMD44_RS16375	COG1316	TRANSCRIPTIONal
SMD44_RS16390	COG1316	TRANSCRIPTIONal
SMD44_RS16410	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SMD44_RS16445	COG2205	protein histidine kinase activity
SMD44_RS16450	COG0745	RESPONSE REGULATOR receiver
SMD44_RS16455	COG3104	oligopeptide transport
SMD44_RS16490	COG1366	Belongs to the anti-sigma-factor antagonist family
SMD44_RS16495	COG1191	sigma factor activity
SMD44_RS16500	COG1228	amidohydrolase
SMD44_RS16515	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SMD44_RS16525	COG0583	DNA-binding transcription factor activity
SMD44_RS16570	COG2986	histidine ammonia-lyase
SMD44_RS16575	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
SMD44_RS16580	COG0288	reversible hydration of carbon dioxide
SMD44_RS16595	COG2755	lipolytic protein G-D-S-L family
SMD44_RS16600	COG0183	Belongs to the thiolase family
SMD44_RS16640	COG1136	(ABC) transporter
SMD44_RS16645	COG0577	efflux transmembrane transporter activity
SMD44_RS16650	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SMD44_RS16675	COG0148	phosphopyruvate hydratase activity
SMD44_RS16760	COG0577	efflux transmembrane transporter activity
SMD44_RS16765	COG1136	(ABC) transporter
SMD44_RS16770	COG0477	Major facilitator Superfamily
SMD44_RS16780	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SMD44_RS16810	COG4585	Histidine kinase
SMD44_RS16830	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SMD44_RS16835	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SMD44_RS16840	COG0193	aminoacyl-tRNA hydrolase activity
SMD44_RS16860	COG1309	transcriptional regulator
SMD44_RS16870	COG4106	trans-aconitate 2-methyltransferase activity
SMD44_RS16875	COG1846	Transcriptional regulator
SMD44_RS16880	COG2197	response regulator
SMD44_RS16910	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SMD44_RS16935	COG0488	(ABC) transporter
SMD44_RS16945	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SMD44_RS16950	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SMD44_RS16960	COG0084	hydrolase, TatD family'
SMD44_RS16990	COG0442	prolyl-tRNA aminoacylation
SMD44_RS17055	COG1122	ATPase activity
SMD44_RS17065	COG0310	cobalt ion transport
SMD44_RS17075	COG2409	Drug exporters of the RND superfamily
SMD44_RS17095	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS17100	COG2267	carboxylic ester hydrolase activity
SMD44_RS17105	COG2072	flavoprotein involved in K transport
SMD44_RS17120	COG0708	Exodeoxyribonuclease III
SMD44_RS17130	COG2205	protein histidine kinase activity
SMD44_RS17140	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SMD44_RS17145	COG1595	DNA-templated transcription, initiation
SMD44_RS17165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMD44_RS17170	COG0521	Mo-molybdopterin cofactor biosynthetic process
SMD44_RS17175	COG0315	cyclic pyranopterin monophosphate synthase activity
SMD44_RS17185	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SMD44_RS17190	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SMD44_RS17195	COG2366	antibiotic biosynthetic process
SMD44_RS17215	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SMD44_RS17235	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SMD44_RS17255	COG1376	ErfK ybiS ycfS ynhG family protein
SMD44_RS17275	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
SMD44_RS17275	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMD44_RS17275	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMD44_RS17285	COG1349	DNA-binding transcription factor activity
SMD44_RS17290	COG0477	Major facilitator Superfamily
SMD44_RS17310	COG1846	Transcriptional regulator
SMD44_RS17330	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SMD44_RS17405	COG2076	Multidrug Resistance protein
SMD44_RS17410	COG0590	tRNA wobble adenosine to inosine editing
SMD44_RS17460	COG0110	maltose O-acetyltransferase activity
SMD44_RS17470	COG4499	WXG100 protein secretion system (Wss), protein YukC
SMD44_RS17470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMD44_RS17490	COG1653	transport
SMD44_RS17500	COG1686	Belongs to the peptidase S11 family
SMD44_RS17625	COG0346	lactoylglutathione lyase activity
SMD44_RS17665	COG1396	sequence-specific DNA binding
SMD44_RS17685	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SMD44_RS17700	COG0640	Transcriptional regulator
SMD44_RS17715	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SMD44_RS17740	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS17745	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SMD44_RS17770	COG3629	intracellular signal transduction
SMD44_RS17770	COG3903	Transcriptional regulator
SMD44_RS17810	COG1024	Enoyl-CoA hydratase
SMD44_RS17815	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMD44_RS17815	COG0515	serine threonine protein kinase
SMD44_RS17825	COG1309	transcriptional regulator
SMD44_RS17835	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS17855	COG0259	pyridoxamine-phosphate oxidase activity
SMD44_RS17875	COG2072	flavoprotein involved in K transport
SMD44_RS17885	COG1024	Enoyl-CoA hydratase
SMD44_RS17945	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS17950	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS17965	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS17970	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS17975	COG0318	PFAM AMP-dependent synthetase and ligase
SMD44_RS18040	COG1131	(ABC) transporter
SMD44_RS18075	COG0577	efflux transmembrane transporter activity
SMD44_RS18080	COG1136	(ABC) transporter
SMD44_RS18095	COG0745	RESPONSE REGULATOR receiver
SMD44_RS18100	COG2205	protein histidine kinase activity
SMD44_RS18105	COG4821	SIS domain
SMD44_RS18115	COG2945	thiolester hydrolase activity
SMD44_RS18115	COG0596	Alpha beta hydrolase
SMD44_RS18120	COG0259	pyridoxamine-phosphate oxidase activity
SMD44_RS18135	COG1024	Enoyl-CoA hydratase
SMD44_RS18150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SMD44_RS18205	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SMD44_RS18225	COG1090	epimerase
SMD44_RS18245	COG1136	(ABC) transporter
SMD44_RS18250	COG0577	efflux transmembrane transporter activity
SMD44_RS18250	COG1136	(ABC) transporter
SMD44_RS18380	COG0667	Aldo Keto reductase
SMD44_RS18410	COG2252	PERMEase
SMD44_RS18420	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SMD44_RS18450	COG2814	Major facilitator Superfamily
SMD44_RS18460	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SMD44_RS18465	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SMD44_RS18470	COG1278	Cold shock
SMD44_RS18490	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD44_RS18495	COG1120	ATPase activity
SMD44_RS18500	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SMD44_RS18535	COG1061	Type III restriction enzyme res subunit
SMD44_RS18545	COG3973	AAA domain
SMD44_RS18590	COG2205	protein histidine kinase activity
SMD44_RS18595	COG0745	RESPONSE REGULATOR receiver
SMD44_RS18610	COG0577	efflux transmembrane transporter activity
SMD44_RS18610	COG1136	(ABC) transporter
SMD44_RS18615	COG1136	(ABC) transporter
SMD44_RS18615	COG0577	efflux transmembrane transporter activity
SMD44_RS18635	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SMD44_RS18655	COG1595	DNA-templated transcription, initiation
SMD44_RS18680	COG0463	Glycosyl transferase, family 2
SMD44_RS18715	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SMD44_RS18775	COG2197	response regulator
SMD44_RS18795	COG4552	Acetyltransferase involved in intracellular survival and related
SMD44_RS18820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMD44_RS18835	COG3842	ATPase activity
SMD44_RS18845	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SMD44_RS18855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SMD44_RS18860	COG0215	cysteine-tRNA ligase activity
SMD44_RS18865	COG3467	pyridoxamine 5'-phosphate
SMD44_RS18870	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SMD44_RS18875	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SMD44_RS18880	COG1329	Transcriptional regulator
SMD44_RS18900	COG5002	protein histidine kinase activity
SMD44_RS18915	COG0588	phosphoglycerate mutase activity
SMD44_RS18945	COG0438	transferase activity, transferring glycosyl groups
SMD44_RS19090	COG2186	Transcriptional regulator
SMD44_RS19110	COG1490	D-aminoacyl-tRNA deacylase activity
SMD44_RS19115	COG0354	folic acid binding
SMD44_RS19125	COG3485	protocatechuate 3,4-dioxygenase
SMD44_RS19145	COG2897	thiosulfate sulfurtransferase activity
SMD44_RS19170	COG0745	RESPONSE REGULATOR receiver
SMD44_RS19175	COG1609	Transcriptional regulator
SMD44_RS19180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMD44_RS19185	COG0745	RESPONSE REGULATOR receiver
SMD44_RS19195	COG0488	(ABC) transporter
SMD44_RS19205	COG0737	Belongs to the 5'-nucleotidase family
SMD44_RS19210	COG0456	acetyltransferase
SMD44_RS19215	COG1725	Transcriptional regulator
SMD44_RS19220	COG1131	(ABC) transporter
SMD44_RS19230	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SMD44_RS19260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SMD44_RS19270	COG0306	phosphate transporter
SMD44_RS19280	COG1937	Protein conserved in bacteria
SMD44_RS19295	COG0277	FAD linked oxidase domain protein
SMD44_RS19300	COG0671	phosphoesterase, PA-phosphatase related
SMD44_RS19305	COG1196	nuclear chromosome segregation
SMD44_RS19305	COG0741	lytic transglycosylase activity
SMD44_RS19305	COG0739	heme binding
SMD44_RS19375	COG1131	(ABC) transporter
SMD44_RS19385	COG4585	Histidine kinase
SMD44_RS19415	COG1846	Transcriptional regulator
SMD44_RS19430	COG1252	NADH dehydrogenase
SMD44_RS19440	COG0366	Alpha amylase catalytic
SMD44_RS19440	COG1470	cell adhesion involved in biofilm formation
SMD44_RS19460	COG0579	oxidoreductase
SMD44_RS19465	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SMD44_RS19475	COG0667	Aldo Keto reductase
SMD44_RS19495	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SMD44_RS19560	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SMD44_RS19575	COG0798	PFAM Bile acid sodium symporter
SMD44_RS19585	COG0640	Transcriptional regulator
SMD44_RS19600	COG0513	Belongs to the DEAD box helicase family
SMD44_RS19630	COG3629	intracellular signal transduction
SMD44_RS19630	COG3903	Transcriptional regulator
SMD44_RS19635	COG1846	Transcriptional regulator
SMD44_RS19640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMD44_RS19670	COG2814	Major facilitator Superfamily
SMD44_RS19675	COG0667	Aldo Keto reductase
SMD44_RS19685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMD44_RS19700	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS19705	COG2197	response regulator
SMD44_RS19730	COG3386	PFAM SMP-30 Gluconolaconase
SMD44_RS19745	COG3629	intracellular signal transduction
SMD44_RS19760	COG0785	Cytochrome C biogenesis protein
SMD44_RS19775	COG1643	Atp-dependent helicase
SMD44_RS19810	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SMD44_RS19845	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SMD44_RS19850	COG0047	phosphoribosylformylglycinamidine synthase activity
SMD44_RS19855	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SMD44_RS19890	COG2197	response regulator
SMD44_RS19900	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SMD44_RS19915	COG0151	Belongs to the GarS family
SMD44_RS19940	COG1609	Transcriptional regulator
SMD44_RS20030	COG0583	DNA-binding transcription factor activity
SMD44_RS20040	COG0488	(ABC) transporter
SMD44_RS20050	COG0433	COG0433 Predicted ATPase
SMD44_RS20065	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SMD44_RS20125	COG1191	sigma factor activity
SMD44_RS20130	COG1191	sigma factor activity
SMD44_RS20150	COG0477	Major facilitator Superfamily
SMD44_RS20160	COG3467	pyridoxamine 5'-phosphate
SMD44_RS20170	COG0477	Major facilitator Superfamily
SMD44_RS20185	COG2205	protein histidine kinase activity
SMD44_RS20190	COG0745	RESPONSE REGULATOR receiver
SMD44_RS20200	COG2329	Antibiotic biosynthesis monooxygenase
SMD44_RS20230	COG1595	DNA-templated transcription, initiation
SMD44_RS20235	COG1252	NADH dehydrogenase
SMD44_RS20265	COG0784	Response regulator, receiver
SMD44_RS20285	COG1309	transcriptional regulator
SMD44_RS20290	COG2814	Major facilitator Superfamily
SMD44_RS20300	COG1595	DNA-templated transcription, initiation
SMD44_RS20320	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS20330	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS20465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMD44_RS20480	COG0653	protein targeting
SMD44_RS20500	COG0006	proline dipeptidase activity
SMD44_RS20510	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMD44_RS20515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMD44_RS20520	COG1733	regulation of RNA biosynthetic process
SMD44_RS20525	COG0702	epimerase
SMD44_RS20530	COG1058	Belongs to the CinA family
SMD44_RS20530	COG1546	Belongs to the CinA family
SMD44_RS20540	COG1902	pentaerythritol trinitrate reductase activity
SMD44_RS20550	COG1803	Methylglyoxal synthase
SMD44_RS20575	COG1999	signal sequence binding
SMD44_RS20590	COG2837	iron assimilation
SMD44_RS20600	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SMD44_RS20605	COG0561	phosphatase activity
SMD44_RS20630	COG1131	(ABC) transporter
SMD44_RS20650	COG0789	Transcriptional regulator
SMD44_RS20665	COG0561	phosphatase activity
SMD44_RS20670	COG0741	lytic transglycosylase activity
SMD44_RS20670	COG1196	nuclear chromosome segregation
SMD44_RS20670	COG0739	heme binding
SMD44_RS20685	COG1294	oxidase, subunit
SMD44_RS20695	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMD44_RS20700	COG1609	Transcriptional regulator
SMD44_RS20705	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SMD44_RS20720	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SMD44_RS20745	COG0662	Cupin 2, conserved barrel domain protein
SMD44_RS20750	COG1950	PFAM Membrane protein of
SMD44_RS20755	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SMD44_RS20760	COG0626	cystathionine gamma-synthase activity
SMD44_RS20800	COG2814	Major facilitator Superfamily
SMD44_RS20810	COG0456	acetyltransferase
SMD44_RS20830	COG0305	Participates in initiation and elongation during chromosome replication
SMD44_RS20840	COG0359	binds to the 23S rRNA
SMD44_RS20845	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SMD44_RS20850	COG0629	single-stranded DNA binding
SMD44_RS20855	COG0360	Binds together with S18 to 16S ribosomal RNA
SMD44_RS20880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMD44_RS20905	COG0617	tRNA 3'-terminal CCA addition
SMD44_RS20920	COG0515	serine threonine protein kinase
SMD44_RS20920	COG2815	serine threonine protein kinase
SMD44_RS20925	COG1595	DNA-templated transcription, initiation
SMD44_RS20935	COG0492	ferredoxin-NADP+ reductase activity
SMD44_RS20940	COG3118	belongs to the thioredoxin family
SMD44_RS20955	COG1192	Involved in chromosome partitioning
SMD44_RS20960	COG0357	Ribosomal RNA small subunit methyltransferase G
SMD44_RS20970	COG0706	membrane insertase activity
SMD44_RS20975	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SMD44_RS20980	COG0594	ribonuclease P activity
SMD44_RS20985	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SMD44_RS20990	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SMD44_RS21000	COG0592	DNA-directed DNA polymerase activity
SMD44_RS21005	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SMD44_RS21010	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SMD44_RS21015	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
SMD44_RS21020	COG0187	DNA topoisomerase II activity
SMD44_RS21025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SMD44_RS21065	COG0515	serine threonine protein kinase
SMD44_RS21090	COG1309	transcriptional regulator
SMD44_RS21100	COG2910	NAD(P)H-binding
SMD44_RS21155	COG0438	transferase activity, transferring glycosyl groups
SMD44_RS21175	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SMD44_RS21180	COG0297	glycogen (starch) synthase activity
SMD44_RS21245	COG2201	protein-glutamate methylesterase activity
SMD44_RS21275	COG0705	Rhomboid family
SMD44_RS21275	COG0457	Tetratricopeptide repeat
SMD44_RS21290	COG3764	Sortase (surface protein transpeptidase)
SMD44_RS21310	COG3764	Sortase (surface protein transpeptidase)
SMD44_RS21315	COG0515	serine threonine protein kinase
SMD44_RS21320	COG0768	penicillin binding
SMD44_RS21335	COG1716	ATPase activity
SMD44_RS21340	COG1716	ATPase activity
SMD44_RS21355	COG0137	argininosuccinate synthase activity
SMD44_RS21360	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SMD44_RS21380	COG1454	alcohol dehydrogenase
SMD44_RS21390	COG0439	Biotin carboxylase
SMD44_RS21485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SMD44_RS21490	COG2226	methyltransferase
SMD44_RS21535	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SMD44_RS21540	COG2151	metal-sulfur cluster biosynthetic enzyme
SMD44_RS21545	COG3396	Phenylacetate-CoA oxygenase
SMD44_RS21550	COG3460	Phenylacetate-CoA oxygenase
SMD44_RS21555	COG3396	Phenylacetate-CoA oxygenase
SMD44_RS21580	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMD44_RS21585	COG1309	transcriptional regulator
SMD44_RS21590	COG1522	sequence-specific DNA binding
SMD44_RS21610	COG0746	molybdenum cofactor guanylyltransferase activity
SMD44_RS21620	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SMD44_RS21660	COG0515	serine threonine protein kinase
SMD44_RS21665	COG0515	serine threonine protein kinase
SMD44_RS21685	COG0022	dehydrogenase e1 component
SMD44_RS21690	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMD44_RS21725	COG1362	aminopeptidase activity
SMD44_RS21730	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS21745	COG1741	Belongs to the pirin family
SMD44_RS21760	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SMD44_RS21835	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMD44_RS21855	COG0583	DNA-binding transcription factor activity
SMD44_RS21885	COG1289	transmembrane transporter activity
SMD44_RS21890	COG0477	Major facilitator Superfamily
SMD44_RS21965	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SMD44_RS21995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD44_RS22050	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SMD44_RS22135	COG0513	Belongs to the DEAD box helicase family
SMD44_RS22140	COG1278	Cold shock
SMD44_RS22155	COG0714	Associated with various cellular activities
SMD44_RS22160	COG3864	Putative metallopeptidase domain
SMD44_RS22170	COG3835	regulator
SMD44_RS22200	COG1309	transcriptional regulator
SMD44_RS22215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMD44_RS22225	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
SMD44_RS22230	COG2188	Transcriptional regulator
SMD44_RS22265	COG0717	Belongs to the dCTP deaminase family
SMD44_RS22325	COG0247	lactate metabolic process
SMD44_RS22325	COG2181	nitrate reductase activity
SMD44_RS22330	COG0443	Heat shock 70 kDa protein
SMD44_RS22335	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SMD44_RS22340	COG0484	heat shock protein binding
SMD44_RS22345	COG0789	Transcriptional regulator
SMD44_RS22415	COG0542	response to heat
SMD44_RS22445	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SMD44_RS22460	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SMD44_RS22465	COG0191	fructose-bisphosphate aldolase activity
SMD44_RS22470	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SMD44_RS22485	COG3844	kynureninase activity
SMD44_RS22495	COG4585	Histidine kinase
SMD44_RS22500	COG2197	response regulator
SMD44_RS22510	COG3559	Exporter of polyketide antibiotics
SMD44_RS22515	COG1131	(ABC) transporter
SMD44_RS22530	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SMD44_RS22570	COG0693	protein deglycase activity
SMD44_RS22600	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SMD44_RS22605	COG1802	Transcriptional regulator
SMD44_RS22610	COG0463	Glycosyl transferase, family 2
SMD44_RS22625	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SMD44_RS22630	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SMD44_RS22655	COG0745	RESPONSE REGULATOR receiver
SMD44_RS22660	COG2205	protein histidine kinase activity
SMD44_RS22665	COG0069	glutamate synthase activity
SMD44_RS22670	COG0028	Belongs to the TPP enzyme family
SMD44_RS22710	COG1595	DNA-templated transcription, initiation
SMD44_RS22745	COG0251	oxidation-reduction process
SMD44_RS22810	COG1309	transcriptional regulator
SMD44_RS22880	COG4555	ABC transporter
SMD44_RS22910	COG3903	Transcriptional regulator
SMD44_RS22910	COG3629	intracellular signal transduction
SMD44_RS22925	COG1609	Transcriptional regulator
SMD44_RS22985	COG1408	metallophosphoesterase
SMD44_RS23010	COG0003	Pfam Anion-transporting ATPase
SMD44_RS23035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SMD44_RS23070	COG0596	Alpha beta hydrolase
SMD44_RS23080	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SMD44_RS23085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMD44_RS23090	COG0659	secondary active sulfate transmembrane transporter activity
SMD44_RS23150	COG1111	helicase
SMD44_RS23150	COG1205	dead DEAH box helicase
SMD44_RS23155	COG1366	Belongs to the anti-sigma-factor antagonist family
SMD44_RS23165	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SMD44_RS23175	COG2890	protein-(glutamine-N5) methyltransferase activity
SMD44_RS23185	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SMD44_RS23185	COG1754	DNA topoisomerase type I activity
SMD44_RS23190	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SMD44_RS23195	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SMD44_RS23235	COG1819	glycosyl
SMD44_RS23255	COG0596	Alpha beta hydrolase
SMD44_RS23290	COG0596	Alpha beta hydrolase
SMD44_RS23290	COG2945	thiolester hydrolase activity
SMD44_RS23295	COG0604	alcohol dehydrogenase
SMD44_RS23305	COG2197	response regulator
SMD44_RS23320	COG1335	isochorismatase
SMD44_RS23330	COG0596	Alpha beta hydrolase
SMD44_RS23335	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SMD44_RS23335	COG1672	PFAM Archaeal ATPase
SMD44_RS23355	COG0745	RESPONSE REGULATOR receiver
SMD44_RS23360	COG5002	protein histidine kinase activity
SMD44_RS23370	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMD44_RS23370	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMD44_RS23375	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SMD44_RS23375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMD44_RS23420	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SMD44_RS23425	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SMD44_RS23430	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SMD44_RS23435	COG0254	rRNA binding
SMD44_RS23445	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SMD44_RS23465	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS23470	COG2318	DinB family
SMD44_RS23495	COG0789	Transcriptional regulator
SMD44_RS23510	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SMD44_RS23515	COG2027	D-alanyl-D-alanine carboxypeptidase
SMD44_RS23525	COG0037	tRNA processing
SMD44_RS23540	COG0302	gtp cyclohydrolase
SMD44_RS23550	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SMD44_RS23555	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SMD44_RS23570	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SMD44_RS23570	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SMD44_RS23585	COG1174	glycine betaine transport
SMD44_RS23590	COG1174	glycine betaine transport
SMD44_RS23615	COG0649	NAD binding
SMD44_RS23645	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
SMD44_RS23655	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SMD44_RS23660	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SMD44_RS23670	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SMD44_RS23695	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SMD44_RS23730	COG0739	heme binding
SMD44_RS23750	COG0346	lactoylglutathione lyase activity
SMD44_RS23755	COG2205	protein histidine kinase activity
SMD44_RS23760	COG0745	RESPONSE REGULATOR receiver
SMD44_RS23770	COG1595	DNA-templated transcription, initiation
SMD44_RS23775	COG1194	a g-specific adenine glycosylase
SMD44_RS23780	COG4585	Histidine kinase
SMD44_RS23790	COG0671	phosphoesterase, PA-phosphatase related
SMD44_RS23800	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
SMD44_RS23820	COG0248	Ppx GppA phosphatase
SMD44_RS23825	COG1082	Xylose isomerase domain protein TIM barrel
SMD44_RS23835	COG0129	dihydroxy-acid dehydratase activity
SMD44_RS23840	COG4991	sh3 domain protein
SMD44_RS23855	COG2226	methyltransferase
SMD44_RS23860	COG0842	Transport permease protein
SMD44_RS23860	COG1129	ABC transporter
SMD44_RS23885	COG0180	Tryptophanyl-tRNA synthetase
SMD44_RS23910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMD44_RS23920	COG0123	including yeast histone deacetylase and acetoin utilization protein
SMD44_RS23970	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SMD44_RS23975	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SMD44_RS23980	COG0181	hydroxymethylbilane synthase activity
SMD44_RS23990	COG0113	porphobilinogen synthase activity
SMD44_RS23995	COG0604	alcohol dehydrogenase
SMD44_RS23995	COG3321	synthase
SMD44_RS24020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMD44_RS24025	COG0018	arginyl-trna synthetase
SMD44_RS24030	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
SMD44_RS24055	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SMD44_RS24060	COG2226	methyltransferase
SMD44_RS24100	COG1690	Belongs to the RtcB family
SMD44_RS24140	COG0583	DNA-binding transcription factor activity
SMD44_RS24150	COG0768	penicillin binding
SMD44_RS24175	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SMD44_RS24180	COG0406	alpha-ribazole phosphatase activity
SMD44_RS24190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMD44_RS24200	COG1333	cytochrome c biogenesis protein
SMD44_RS24205	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SMD44_RS24235	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SMD44_RS24240	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SMD44_RS24245	COG0163	prenyltransferase activity
SMD44_RS24255	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SMD44_RS24265	COG1301	dicarboxylic acid transport
SMD44_RS24270	COG1309	transcriptional regulator
SMD44_RS24365	COG0747	negative chemotaxis
SMD44_RS24370	COG0601	transmembrane transport
SMD44_RS24375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMD44_RS24390	COG1278	Cold shock
SMD44_RS24395	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SMD44_RS24415	COG1674	ftsk spoiiie
SMD44_RS24480	COG1660	Displays ATPase and GTPase activities
SMD44_RS24485	COG2318	DinB family
SMD44_RS24490	COG5640	endopeptidase activity
SMD44_RS24550	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SMD44_RS24560	COG2226	methyltransferase
SMD44_RS24595	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SMD44_RS24765	COG1396	sequence-specific DNA binding
SMD44_RS24815	COG3723	Recombinational DNA repair protein, rece pathway
SMD44_RS24820	COG5377	YqaJ viral recombinase family
SMD44_RS24840	COG3103	Sh3 type 3 domain protein
SMD44_RS24840	COG0791	NLP P60 protein
SMD44_RS24840	COG1388	LysM domain
SMD44_RS24855	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMD44_RS24860	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMD44_RS24865	COG0649	NAD binding
SMD44_RS24875	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SMD44_RS24880	COG1034	ATP synthesis coupled electron transport
SMD44_RS24885	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SMD44_RS24890	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMD44_RS24895	COG0839	Belongs to the complex I subunit 6 family
SMD44_RS24900	COG0713	ATP synthesis coupled electron transport
SMD44_RS24905	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SMD44_RS24915	COG1007	ATP synthesis coupled electron transport
SMD44_RS24920	COG0514	ATP-dependent DNA helicase (RecQ)
SMD44_RS24955	COG0561	phosphatase activity
SMD44_RS24960	COG0142	geranyltranstransferase activity
SMD44_RS25015	COG0662	Cupin 2, conserved barrel domain protein
SMD44_RS25030	COG1733	regulation of RNA biosynthetic process
SMD44_RS25055	COG0702	epimerase
SMD44_RS25060	COG1733	regulation of RNA biosynthetic process
SMD44_RS25065	COG1013	pyruvate-flavodoxin oxidoreductase activity
SMD44_RS25070	COG0674	pyruvate-flavodoxin oxidoreductase activity
SMD44_RS25070	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SMD44_RS25090	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMD44_RS25095	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMD44_RS25100	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMD44_RS25105	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SMD44_RS25110	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMD44_RS25120	COG0713	ATP synthesis coupled electron transport
SMD44_RS25125	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SMD44_RS25135	COG1007	ATP synthesis coupled electron transport
SMD44_RS25140	COG0501	Belongs to the peptidase M48B family
SMD44_RS25145	COG3304	Inner membrane component domain
SMD44_RS25150	COG2261	transglycosylase associated protein
SMD44_RS25155	COG1666	GTP binding
SMD44_RS25170	COG0702	epimerase
SMD44_RS25190	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SMD44_RS25195	COG2030	dehydratase
SMD44_RS25210	COG0477	Major facilitator Superfamily
SMD44_RS25215	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SMD44_RS25220	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SMD44_RS25225	COG0436	Aminotransferase
SMD44_RS25240	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SMD44_RS25245	COG0250	Participates in transcription elongation, termination and antitermination
SMD44_RS25255	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SMD44_RS25260	COG0081	regulation of translation
SMD44_RS25275	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SMD44_RS25280	COG0222	ribosome binding
SMD44_RS25290	COG0085	RNA polymerase activity
SMD44_RS25295	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SMD44_RS25305	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SMD44_RS25310	COG0049	tRNA binding
SMD44_RS25315	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SMD44_RS25320	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SMD44_RS25325	COG0051	transcription antitermination factor activity, RNA binding
SMD44_RS25330	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SMD44_RS25335	COG0088	Forms part of the polypeptide exit tunnel
SMD44_RS25340	COG0089	rRNA binding
SMD44_RS25345	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SMD44_RS25350	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SMD44_RS25355	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SMD44_RS25360	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SMD44_RS25365	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SMD44_RS25370	COG0255	Belongs to the universal ribosomal protein uL29 family
SMD44_RS25375	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SMD44_RS25380	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SMD44_RS25385	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SMD44_RS25390	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SMD44_RS25395	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SMD44_RS25405	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SMD44_RS25410	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SMD44_RS25415	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SMD44_RS25420	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SMD44_RS25425	COG1841	ribosomal large subunit assembly
SMD44_RS25430	COG0200	Binds to the 23S rRNA
SMD44_RS25440	COG0563	adenylate kinase activity
SMD44_RS25450	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SMD44_RS25455	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SMD44_RS25460	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SMD44_RS25465	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SMD44_RS25470	COG0202	RNA polymerase activity
SMD44_RS25475	COG0203	ribosomal protein L17
SMD44_RS25480	COG0101	tRNA pseudouridine synthase activity
SMD44_RS25495	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SMD44_RS25500	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SMD44_RS25505	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMD44_RS25515	COG1072	(Pantothenic acid kinase))
SMD44_RS25520	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMD44_RS25525	COG0736	holo-[acyl-carrier-protein] synthase activity
SMD44_RS25535	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SMD44_RS25545	COG0802	atpase or kinase
SMD44_RS25560	COG1214	PFAM Peptidase M22, glycoprotease
SMD44_RS25560	COG0456	acetyltransferase
SMD44_RS25570	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SMD44_RS25595	COG0726	polysaccharide deacetylase
SMD44_RS25605	COG0459	protein refolding
SMD44_RS25610	COG4221	oxidoreductase activity
SMD44_RS25615	COG2132	Multicopper oxidase
SMD44_RS25625	COG0583	DNA-binding transcription factor activity
SMD44_RS25640	COG1595	DNA-templated transcription, initiation
SMD44_RS25650	COG0516	GMP reductase activity
SMD44_RS25680	COG0515	serine threonine protein kinase
SMD44_RS25685	COG0515	serine threonine protein kinase
SMD44_RS25690	COG0515	serine threonine protein kinase
SMD44_RS25700	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS25730	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SMD44_RS25730	COG0519	Catalyzes the synthesis of GMP from XMP
SMD44_RS25770	COG2197	response regulator
SMD44_RS25775	COG0791	NLP P60 protein
SMD44_RS25805	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SMD44_RS25805	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SMD44_RS25820	COG0714	Associated with various cellular activities
SMD44_RS25830	COG3552	Protein containing von Willebrand factor type A (VWA) domain
SMD44_RS25835	COG0045	succinate-CoA ligase (ADP-forming) activity
SMD44_RS25865	COG0138	bifunctional purine biosynthesis protein purh
SMD44_RS25875	COG2815	serine threonine protein kinase
SMD44_RS25875	COG0515	serine threonine protein kinase
SMD44_RS25880	COG1714	RDD family
SMD44_RS25885	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SMD44_RS25895	COG4585	Histidine kinase
SMD44_RS25900	COG2197	response regulator
SMD44_RS25930	COG0039	L-malate dehydrogenase activity
SMD44_RS25960	COG0477	Major facilitator Superfamily
SMD44_RS25970	COG1476	TRANSCRIPTIONal
SMD44_RS25985	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS25995	COG4175	Glycine betaine
SMD44_RS25995	COG0517	IMP dehydrogenase activity
SMD44_RS26000	COG4176	ABC-type proline glycine betaine transport system permease component
SMD44_RS26015	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMD44_RS26020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMD44_RS26030	COG1959	2 iron, 2 sulfur cluster binding
SMD44_RS26055	COG0754	glutathionylspermidine amidase activity
SMD44_RS26095	COG2409	Drug exporters of the RND superfamily
SMD44_RS26170	COG1595	DNA-templated transcription, initiation
SMD44_RS26180	COG2318	DinB family
SMD44_RS26210	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMD44_RS26215	COG2130	NADP-dependent
SMD44_RS26225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMD44_RS26230	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SMD44_RS26245	COG1595	DNA-templated transcription, initiation
SMD44_RS26275	COG0671	phosphoesterase, PA-phosphatase related
SMD44_RS26290	COG1295	ribonuclease BN
SMD44_RS26295	COG1686	Belongs to the peptidase S11 family
SMD44_RS26305	COG1408	metallophosphoesterase
SMD44_RS26310	COG2205	protein histidine kinase activity
SMD44_RS26315	COG0745	RESPONSE REGULATOR receiver
SMD44_RS26320	COG2409	Drug exporters of the RND superfamily
SMD44_RS26325	COG1595	DNA-templated transcription, initiation
SMD44_RS26345	COG1846	Transcriptional regulator
SMD44_RS26370	COG1140	nitrate reductase beta subunit
SMD44_RS26395	COG1053	succinate dehydrogenase
SMD44_RS26405	COG2009	succinate dehydrogenase
SMD44_RS26415	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SMD44_RS26445	COG1595	DNA-templated transcription, initiation
SMD44_RS26485	COG1216	Glycosyl transferase, family 2
SMD44_RS26500	COG2089	acid synthase
SMD44_RS26575	COG1473	amidohydrolase
SMD44_RS26575	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SMD44_RS26580	COG1744	ABC transporter substrate-binding protein PnrA-like
SMD44_RS26585	COG1744	ABC transporter substrate-binding protein PnrA-like
SMD44_RS26590	COG3845	ABC transporter
SMD44_RS26600	COG1079	Belongs to the binding-protein-dependent transport system permease family
SMD44_RS26615	COG0583	DNA-binding transcription factor activity
SMD44_RS26620	COG2814	Major facilitator Superfamily
SMD44_RS26640	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SMD44_RS26665	COG2205	protein histidine kinase activity
SMD44_RS26670	COG0745	RESPONSE REGULATOR receiver
SMD44_RS26675	COG1595	DNA-templated transcription, initiation
SMD44_RS26690	COG2197	response regulator
SMD44_RS26705	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS26710	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS26715	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SMD44_RS26770	COG4770	biotin carboxylase activity
SMD44_RS26780	COG0424	maF-like protein
SMD44_RS26800	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SMD44_RS26810	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SMD44_RS26815	COG1024	Enoyl-CoA hydratase
SMD44_RS26830	COG2986	histidine ammonia-lyase
SMD44_RS26865	COG1733	regulation of RNA biosynthetic process
SMD44_RS26885	COG1064	alcohol dehydrogenase
SMD44_RS26895	COG2267	carboxylic ester hydrolase activity
SMD44_RS26900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMD44_RS26920	COG1595	DNA-templated transcription, initiation
SMD44_RS26925	COG2255	four-way junction helicase activity
SMD44_RS26930	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SMD44_RS26960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SMD44_RS26970	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SMD44_RS27000	COG1331	Highly conserved protein containing a thioredoxin domain
SMD44_RS27015	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
SMD44_RS27025	COG0436	Aminotransferase
SMD44_RS27035	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SMD44_RS27050	COG1414	Transcriptional regulator
SMD44_RS27060	COG2610	gluconate transmembrane transporter activity
SMD44_RS27150	COG2894	cell division
SMD44_RS27195	COG2885	chlorophyll binding
SMD44_RS27215	COG1733	regulation of RNA biosynthetic process
SMD44_RS27220	COG0667	Aldo Keto reductase
SMD44_RS27225	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SMD44_RS27230	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SMD44_RS27245	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMD44_RS27250	COG0450	alkyl hydroperoxide reductase
SMD44_RS27265	COG1136	(ABC) transporter
SMD44_RS27275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMD44_RS27300	COG0114	fumarate hydratase activity
SMD44_RS27335	COG0778	Nitroreductase
SMD44_RS27340	COG1722	exodeoxyribonuclease VII activity
SMD44_RS27345	COG1570	exodeoxyribonuclease VII activity
SMD44_RS27355	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SMD44_RS27370	COG0012	GTP binding
SMD44_RS27375	COG2161	toxin-antitoxin pair type II binding
SMD44_RS27380	COG4115	mRNA cleavage
SMD44_RS27405	COG1846	Transcriptional regulator
SMD44_RS27460	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SMD44_RS27485	COG1217	gtp-binding protein TYPA
SMD44_RS27495	COG0601	transmembrane transport
SMD44_RS27500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMD44_RS27505	COG0444	Belongs to the ABC transporter superfamily
SMD44_RS27510	COG4608	Belongs to the ABC transporter superfamily
SMD44_RS27525	COG0601	transmembrane transport
SMD44_RS27530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMD44_RS27535	COG0444	Belongs to the ABC transporter superfamily
SMD44_RS27540	COG4608	Belongs to the ABC transporter superfamily
SMD44_RS27555	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SMD44_RS27570	COG1131	(ABC) transporter
SMD44_RS27575	COG0842	Transport permease protein
SMD44_RS27580	COG4585	Histidine kinase
SMD44_RS27585	COG2197	response regulator
SMD44_RS27625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMD44_RS27630	COG1611	Belongs to the LOG family
SMD44_RS27635	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SMD44_RS27645	COG2818	Glycosylase
SMD44_RS27650	COG1024	Enoyl-CoA hydratase
SMD44_RS27665	COG1595	DNA-templated transcription, initiation
SMD44_RS27675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMD44_RS27680	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SMD44_RS27715	COG0598	Magnesium transport protein CorA
SMD44_RS27740	COG2095	MarC family integral membrane protein
SMD44_RS27750	COG1432	Conserved Protein
SMD44_RS27755	COG0596	Alpha beta hydrolase
SMD44_RS27760	COG0513	Belongs to the DEAD box helicase family
SMD44_RS27800	COG0747	negative chemotaxis
SMD44_RS27810	COG0601	transmembrane transport
SMD44_RS27880	COG0210	DNA helicase
SMD44_RS27885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMD44_RS27930	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SMD44_RS27985	COG3480	Lon protease (S16) C-terminal proteolytic domain
SMD44_RS27995	COG1615	UPF0182 protein
SMD44_RS28020	COG0753	catalase activity
SMD44_RS28030	COG0483	inositol monophosphate 1-phosphatase activity
SMD44_RS28040	COG2076	Multidrug Resistance protein
SMD44_RS28045	COG1162	GTPase activity
SMD44_RS28050	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SMD44_RS28060	COG2135	peptidase activity
SMD44_RS28070	COG1595	DNA-templated transcription, initiation
SMD44_RS28075	COG5662	AntiSigma factor
SMD44_RS28080	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SMD44_RS28080	COG2199	diguanylate cyclase activity
SMD44_RS28095	COG0242	peptide deformylase activity
SMD44_RS28105	COG2124	cytochrome p450
SMD44_RS28120	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMD44_RS28160	COG2182	Extracellular solute-binding protein
SMD44_RS28165	COG1175	transmembrane transport
SMD44_RS28170	COG0395	ABC-type sugar transport system, permease component
SMD44_RS28175	COG1472	Belongs to the glycosyl hydrolase 3 family
SMD44_RS28180	COG0363	glucosamine-6-phosphate deaminase activity
SMD44_RS28185	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMD44_RS28190	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS28195	COG1309	transcriptional regulator
SMD44_RS28210	COG1597	lipid kinase activity
SMD44_RS28225	COG2172	sigma factor antagonist activity
SMD44_RS28255	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMD44_RS28260	COG0142	geranyltranstransferase activity
SMD44_RS28290	COG1595	DNA-templated transcription, initiation
SMD44_RS28315	COG4106	trans-aconitate 2-methyltransferase activity
SMD44_RS28320	COG1126	abc transporter atp-binding protein
SMD44_RS28340	COG0604	alcohol dehydrogenase
SMD44_RS28390	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMD44_RS28390	COG0567	Dehydrogenase, E1 component
SMD44_RS28395	COG2205	protein histidine kinase activity
SMD44_RS28400	COG0745	RESPONSE REGULATOR receiver
SMD44_RS28430	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SMD44_RS28505	COG2318	DinB family
SMD44_RS28510	COG0768	penicillin binding
SMD44_RS28515	COG0772	Belongs to the SEDS family
SMD44_RS28525	COG2205	protein histidine kinase activity
SMD44_RS28555	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SMD44_RS28560	COG2267	carboxylic ester hydrolase activity
SMD44_RS28580	COG0745	RESPONSE REGULATOR receiver
SMD44_RS28585	COG0018	arginyl-trna synthetase
SMD44_RS28590	COG0019	diaminopimelate decarboxylase activity
SMD44_RS28595	COG0460	homoserine dehydrogenase
SMD44_RS28600	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SMD44_RS28605	COG0083	homoserine kinase activity
SMD44_RS28620	COG0254	rRNA binding
SMD44_RS28625	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SMD44_RS28630	COG2890	protein-(glutamine-N5) methyltransferase activity
SMD44_RS28640	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SMD44_RS28645	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SMD44_RS28665	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SMD44_RS28670	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SMD44_RS28675	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SMD44_RS28680	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SMD44_RS28685	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SMD44_RS28690	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SMD44_RS28695	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SMD44_RS28710	COG2197	response regulator
SMD44_RS28715	COG4585	Histidine kinase
SMD44_RS28745	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMD44_RS28760	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
SMD44_RS28825	COG0183	Belongs to the thiolase family
SMD44_RS28840	COG0745	RESPONSE REGULATOR receiver
SMD44_RS28845	COG2205	protein histidine kinase activity
SMD44_RS28935	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SMD44_RS28935	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SMD44_RS28950	COG1476	TRANSCRIPTIONal
SMD44_RS28975	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SMD44_RS28980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMD44_RS29020	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SMD44_RS29025	COG0857	belongs to the CobB CobQ family
SMD44_RS29025	COG0280	phosphate acetyltransferase
SMD44_RS29030	COG0205	6-phosphofructokinase activity
SMD44_RS29040	COG0395	ABC-type sugar transport system, permease component
SMD44_RS29055	COG4565	transcriptional regulatory protein
SMD44_RS29060	COG3290	protein histidine kinase activity
SMD44_RS29065	COG1301	dicarboxylic acid transport
SMD44_RS29110	COG0477	Major facilitator Superfamily
SMD44_RS29135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMD44_RS29140	COG0515	serine threonine protein kinase
SMD44_RS29170	COG2226	methyltransferase
SMD44_RS29175	COG2409	Drug exporters of the RND superfamily
SMD44_RS29185	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SMD44_RS29190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMD44_RS29225	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SMD44_RS29230	COG3281	Trehalose synthase
SMD44_RS29260	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMD44_RS29260	COG0515	serine threonine protein kinase
SMD44_RS29265	COG0515	serine threonine protein kinase
SMD44_RS29265	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMD44_RS29270	COG0515	serine threonine protein kinase
SMD44_RS29270	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMD44_RS29275	COG0058	SHG alpha-glucan phosphorylase activity
SMD44_RS29305	COG1132	(ABC) transporter
SMD44_RS29310	COG1132	(ABC) transporter
SMD44_RS29315	COG1131	(ABC) transporter
SMD44_RS29330	COG4585	Histidine kinase
SMD44_RS29335	COG2197	response regulator
SMD44_RS29355	COG1376	ErfK ybiS ycfS ynhG family protein
SMD44_RS29400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMD44_RS29410	COG2367	Beta-lactamase
SMD44_RS29415	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SMD44_RS29425	COG0604	alcohol dehydrogenase
SMD44_RS29445	COG1760	l-serine dehydratase
SMD44_RS29450	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SMD44_RS29455	COG0509	glycine decarboxylation via glycine cleavage system
SMD44_RS29460	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SMD44_RS29480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMD44_RS29485	COG0747	negative chemotaxis
SMD44_RS29495	COG0444	Belongs to the ABC transporter superfamily
SMD44_RS29500	COG4608	Belongs to the ABC transporter superfamily
SMD44_RS29505	COG2860	membrane
SMD44_RS29515	COG2855	membrane
SMD44_RS29525	COG0583	DNA-binding transcription factor activity
SMD44_RS29530	COG2378	regulation of single-species biofilm formation
SMD44_RS29535	COG0596	Alpha beta hydrolase
SMD44_RS29565	COG0482	sulfurtransferase activity
SMD44_RS29590	COG4221	oxidoreductase activity
SMD44_RS29600	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SMD44_RS29620	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SMD44_RS29625	COG0154	amidase activity
SMD44_RS29635	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SMD44_RS29650	COG2409	Drug exporters of the RND superfamily
SMD44_RS29655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMD44_RS29670	COG2197	response regulator
SMD44_RS29685	COG0667	Aldo Keto reductase
SMD44_RS29710	COG0440	acetolactate synthase activity
SMD44_RS29715	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SMD44_RS29720	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMD44_RS29725	COG0477	Major facilitator Superfamily
SMD44_RS29750	COG0506	proline dehydrogenase activity
SMD44_RS29755	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS29765	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
SMD44_RS29765	COG0778	Nitroreductase
SMD44_RS29775	COG0575	Belongs to the CDS family
SMD44_RS29790	COG2130	NADP-dependent
SMD44_RS29795	COG0583	DNA-binding transcription factor activity
SMD44_RS29815	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SMD44_RS29820	COG1309	transcriptional regulator
SMD44_RS29835	COG0831	urea catabolic process
SMD44_RS29835	COG0832	Belongs to the urease beta subunit family
SMD44_RS29840	COG0804	urea catabolic process
SMD44_RS29845	COG2957	Belongs to the agmatine deiminase family
SMD44_RS29885	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMD44_RS29935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SMD44_RS29960	COG2018	Roadblock/LC7 domain
SMD44_RS29980	COG2018	Roadblock/LC7 domain
SMD44_RS29985	COG5002	protein histidine kinase activity
SMD44_RS29995	COG0179	Fumarylacetoacetate (FAA) hydrolase
SMD44_RS30000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMD44_RS30035	COG1414	Transcriptional regulator
SMD44_RS30040	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SMD44_RS30045	COG0066	3-isopropylmalate dehydratase activity
SMD44_RS30055	COG0776	regulation of translation
SMD44_RS30065	COG1920	GTP binding
SMD44_RS30075	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SMD44_RS30080	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMD44_RS30100	COG0351	phosphomethylpyrimidine kinase
SMD44_RS30115	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SMD44_RS30130	COG0742	ribosomal rna small subunit methyltransferase
SMD44_RS30135	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SMD44_RS30150	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SMD44_RS30155	COG0571	ribonuclease III activity
SMD44_RS30160	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SMD44_RS30165	COG1733	regulation of RNA biosynthetic process
SMD44_RS30175	COG2340	Cysteine-rich secretory protein family
SMD44_RS30180	COG1254	Belongs to the acylphosphatase family
SMD44_RS30190	COG1196	nuclear chromosome segregation
SMD44_RS30195	COG0477	Major facilitator Superfamily
SMD44_RS30205	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
SMD44_RS30235	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SMD44_RS30245	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMD44_RS30260	COG0442	prolyl-tRNA aminoacylation
SMD44_RS30270	COG0228	four-way junction DNA binding
SMD44_RS30275	COG1837	Belongs to the UPF0109 family
SMD44_RS30280	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SMD44_RS30285	COG0336	Belongs to the RNA methyltransferase TrmD family
SMD44_RS30290	COG0335	large ribosomal subunit rRNA binding
SMD44_RS30300	COG0681	Belongs to the peptidase S26 family
SMD44_RS30305	COG0681	Belongs to the peptidase S26 family
SMD44_RS30310	COG0681	Belongs to the peptidase S26 family
SMD44_RS30325	COG0792	nuclease activity
SMD44_RS30340	COG1191	sigma factor activity
SMD44_RS30355	COG0052	Belongs to the universal ribosomal protein uS2 family
SMD44_RS30360	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SMD44_RS30365	COG0528	UMP kinase activity
SMD44_RS30370	COG0233	cytoplasmic translational termination
SMD44_RS30375	COG0575	Belongs to the CDS family
SMD44_RS30380	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SMD44_RS30395	COG3842	ATPase activity
SMD44_RS30420	COG4181	ATPase activity
SMD44_RS30425	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SMD44_RS30435	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS30455	COG1309	transcriptional regulator
SMD44_RS30460	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS30470	COG1733	regulation of RNA biosynthetic process
SMD44_RS30490	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SMD44_RS30500	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS30510	COG3842	ATPase activity
SMD44_RS30515	COG1176	ABC-type spermidine putrescine transport system, permease component I
SMD44_RS30520	COG1177	transmembrane transport
SMD44_RS30525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMD44_RS30560	COG2508	Transcriptional regulator
SMD44_RS30565	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS30580	COG0750	zinc metalloprotease
SMD44_RS30585	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SMD44_RS30590	COG1609	Transcriptional regulator
SMD44_RS30615	COG0442	prolyl-tRNA aminoacylation
SMD44_RS30635	COG0779	Required for maturation of 30S ribosomal subunits
SMD44_RS30650	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SMD44_RS30660	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SMD44_RS30665	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SMD44_RS30700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMD44_RS30705	COG0601	transmembrane transport
SMD44_RS30735	COG1404	Belongs to the peptidase S8 family
SMD44_RS30795	COG1674	ftsk spoiiie
SMD44_RS30805	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SMD44_RS30810	COG1185	polyribonucleotide nucleotidyltransferase activity
SMD44_RS30815	COG0612	Peptidase, M16
SMD44_RS30820	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SMD44_RS30845	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SMD44_RS30880	COG2208	phosphoserine phosphatase activity
SMD44_RS30880	COG2770	Histidine kinase
SMD44_RS30890	COG4999	Histidine kinase
SMD44_RS30890	COG3437	response regulator, receiver
SMD44_RS30890	COG3850	Histidine kinase
SMD44_RS30890	COG2205	protein histidine kinase activity
SMD44_RS30900	COG1674	ftsk spoiiie
SMD44_RS30910	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SMD44_RS30920	COG1546	Belongs to the CinA family
SMD44_RS30920	COG1058	Belongs to the CinA family
SMD44_RS30925	COG1396	sequence-specific DNA binding
SMD44_RS30930	COG0783	Belongs to the Dps family
SMD44_RS30940	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS30945	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SMD44_RS30980	COG0628	permease
SMD44_RS30990	COG0640	Transcriptional regulator
SMD44_RS30995	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SMD44_RS31030	COG0765	amino acid transport
SMD44_RS31035	COG0765	amino acid transport
SMD44_RS31040	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
SMD44_RS31045	COG1126	abc transporter atp-binding protein
SMD44_RS31055	COG2205	protein histidine kinase activity
SMD44_RS31095	COG1595	DNA-templated transcription, initiation
SMD44_RS31115	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SMD44_RS31135	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SMD44_RS31145	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SMD44_RS31150	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SMD44_RS31160	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SMD44_RS31200	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SMD44_RS31205	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SMD44_RS31210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMD44_RS31235	COG0488	(ABC) transporter
SMD44_RS31240	COG0588	phosphoglycerate mutase activity
SMD44_RS31260	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SMD44_RS31300	COG1116	anion transmembrane transporter activity
SMD44_RS31305	COG1802	Transcriptional regulator
SMD44_RS31310	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SMD44_RS31325	COG0187	DNA topoisomerase II activity
SMD44_RS31335	COG4585	Histidine kinase
SMD44_RS31340	COG2197	response regulator
SMD44_RS31350	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SMD44_RS31355	COG4565	transcriptional regulatory protein
SMD44_RS31360	COG3290	protein histidine kinase activity
SMD44_RS31375	COG0372	Belongs to the citrate synthase family
SMD44_RS31395	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SMD44_RS31400	COG0612	Peptidase, M16
SMD44_RS31415	COG1802	Transcriptional regulator
SMD44_RS31420	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMD44_RS31430	COG0045	succinate-CoA ligase (ADP-forming) activity
SMD44_RS31430	COG1042	CoA-binding domain protein
SMD44_RS31430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMD44_RS31445	COG1435	thymidine kinase activity
SMD44_RS31490	COG0745	RESPONSE REGULATOR receiver
SMD44_RS31495	COG2205	protein histidine kinase activity
SMD44_RS31520	COG0756	dUTP diphosphatase activity
SMD44_RS31535	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SMD44_RS31540	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SMD44_RS31545	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SMD44_RS31590	COG2124	cytochrome p450
SMD44_RS31625	COG0475	glutathione-regulated potassium exporter activity
SMD44_RS31650	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS31655	COG0436	Aminotransferase
SMD44_RS31660	COG3483	tryptophan 2,3-dioxygenase activity
SMD44_RS31695	COG0569	domain protein
SMD44_RS31715	COG0531	amino acid
SMD44_RS31720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SMD44_RS31765	COG2080	2 iron, 2 sulfur cluster binding
SMD44_RS31765	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMD44_RS31770	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SMD44_RS31815	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SMD44_RS31835	COG1132	(ABC) transporter
SMD44_RS31855	COG1799	cell septum assembly
SMD44_RS31890	COG2197	response regulator
SMD44_RS31895	COG4585	Histidine kinase
SMD44_RS31905	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SMD44_RS31915	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SMD44_RS31920	COG2235	arginine
SMD44_RS31925	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SMD44_RS31935	COG1024	Enoyl-CoA hydratase
SMD44_RS31980	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SMD44_RS32000	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SMD44_RS32040	COG3537	Alpha-1,2-mannosidase
SMD44_RS32060	COG1175	transmembrane transport
SMD44_RS32065	COG0395	ABC-type sugar transport system, permease component
SMD44_RS32070	COG1940	carbohydrate kinase activity
SMD44_RS32075	COG4213	ABC transporter substrate-binding protein
SMD44_RS32085	COG4214	carbohydrate transport
SMD44_RS32090	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SMD44_RS32095	COG0531	amino acid
SMD44_RS32105	COG2843	Capsule synthesis protein
SMD44_RS32140	COG1024	Enoyl-CoA hydratase
SMD44_RS32140	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMD44_RS32170	COG0446	pyridine nucleotide-disulphide oxidoreductase
SMD44_RS32180	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SMD44_RS32185	COG3253	May function as heme-dependent peroxidase
SMD44_RS32210	COG3220	belongs to the UPF0276 family
SMD44_RS32250	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SMD44_RS32255	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
SMD44_RS32285	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SMD44_RS32290	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMD44_RS32305	COG2124	cytochrome p450
SMD44_RS32350	COG0443	Heat shock 70 kDa protein
SMD44_RS32355	COG0443	Heat shock 70 kDa protein
SMD44_RS32360	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SMD44_RS32400	COG0504	CTP synthase activity
SMD44_RS32405	COG0583	DNA-binding transcription factor activity
SMD44_RS32420	COG1280	lysine exporter protein (LysE YggA)
SMD44_RS32430	COG0667	Aldo Keto reductase
SMD44_RS32445	COG0723	plastoquinol--plastocyanin reductase activity
SMD44_RS32445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMD44_RS32535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMD44_RS32540	COG2364	Membrane
SMD44_RS32565	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SMD44_RS32580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SMD44_RS32585	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
SMD44_RS32605	COG0529	Catalyzes the synthesis of activated sulfate
SMD44_RS32610	COG0175	sulfate reduction
SMD44_RS32635	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS32665	COG1051	belongs to the nudix hydrolase family
SMD44_RS32695	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SMD44_RS32705	COG1162	GTPase activity
SMD44_RS32715	COG5297	Belongs to the glycosyl hydrolase family 6
SMD44_RS32715	COG3250	beta-galactosidase activity
SMD44_RS32755	COG0028	Belongs to the TPP enzyme family
SMD44_RS32780	COG1802	Transcriptional regulator
SMD44_RS32805	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMD44_RS32810	COG2252	PERMEase
SMD44_RS32830	COG2124	cytochrome p450
SMD44_RS32925	COG0464	growth
SMD44_RS32995	COG0596	Alpha beta hydrolase
SMD44_RS33000	COG2197	response regulator
SMD44_RS33005	COG1090	epimerase
SMD44_RS33010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SMD44_RS33020	COG2132	Multicopper oxidase
SMD44_RS33030	COG2197	response regulator
SMD44_RS33035	COG0598	Magnesium transport protein CorA
SMD44_RS33050	COG2197	response regulator
SMD44_RS33055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMD44_RS33060	COG0318	PFAM AMP-dependent synthetase and ligase
SMD44_RS33070	COG3960	tartronate-semialdehyde synthase activity
SMD44_RS33075	COG0477	Major facilitator Superfamily
SMD44_RS33095	COG0753	catalase activity
SMD44_RS33100	COG2084	Dehydrogenase
SMD44_RS33105	COG3622	Belongs to the hyi family
SMD44_RS33125	COG2351	hydroxyisourate hydrolase activity
SMD44_RS33135	COG2233	PERMEase
SMD44_RS33145	COG2233	PERMEase
SMD44_RS33175	COG2133	pyrroloquinoline quinone binding
SMD44_RS33175	COG5183	chlorophyll binding
SMD44_RS33225	COG0667	Aldo Keto reductase
SMD44_RS33240	COG0588	phosphoglycerate mutase activity
SMD44_RS33260	COG0436	Aminotransferase
SMD44_RS33290	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SMD44_RS33305	COG1414	Transcriptional regulator
SMD44_RS33310	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SMD44_RS33315	COG4266	Belongs to the allantoicase family
SMD44_RS33320	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS33355	COG2197	response regulator
SMD44_RS33370	COG0673	inositol 2-dehydrogenase activity
SMD44_RS33375	COG2188	Transcriptional regulator
SMD44_RS33400	COG1940	carbohydrate kinase activity
SMD44_RS33445	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SMD44_RS33450	COG2801	Transposase and inactivated derivatives
SMD44_RS33560	COG1302	Protein conserved in bacteria
SMD44_RS33580	COG4585	Histidine kinase
SMD44_RS33585	COG2197	response regulator
SMD44_RS33635	COG1132	(ABC) transporter
SMD44_RS33670	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SMD44_RS33695	COG1126	abc transporter atp-binding protein
SMD44_RS33700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMD44_RS33705	COG0765	amino acid transport
SMD44_RS33710	COG0765	amino acid transport
SMD44_RS33720	COG1376	ErfK ybiS ycfS ynhG family protein
SMD44_RS33750	COG0477	Major facilitator Superfamily
SMD44_RS33775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMD44_RS33780	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SMD44_RS33790	COG3291	Pkd domain containing protein
SMD44_RS33795	COG1802	Transcriptional regulator
SMD44_RS33805	COG1953	Uracil, thiamine, allantoin
SMD44_RS33815	COG4585	Histidine kinase
SMD44_RS33820	COG2197	response regulator
SMD44_RS33855	COG2124	cytochrome p450
SMD44_RS33870	COG0483	inositol monophosphate 1-phosphatase activity
SMD44_RS33895	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMD44_RS33940	COG1929	Belongs to the glycerate kinase type-1 family
SMD44_RS33950	COG0688	phosphatidylethanolamine metabolic process
SMD44_RS33955	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS33965	COG2301	Belongs to the HpcH HpaI aldolase family
SMD44_RS33970	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SMD44_RS33970	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SMD44_RS33975	COG0604	alcohol dehydrogenase
SMD44_RS33985	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMD44_RS34035	COG2226	methyltransferase
SMD44_RS34060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMD44_RS34070	COG1619	proteins homologs of microcin C7 resistance protein MccF
SMD44_RS34080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMD44_RS34115	COG1252	NADH dehydrogenase
SMD44_RS34170	COG2226	methyltransferase
SMD44_RS34175	COG1597	lipid kinase activity
SMD44_RS34180	COG0488	(ABC) transporter
SMD44_RS34265	COG1404	Belongs to the peptidase S8 family
SMD44_RS34275	COG0443	Heat shock 70 kDa protein
SMD44_RS34290	COG2154	pterin-4-alpha-carbinolamine dehydratase
SMD44_RS34330	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SMD44_RS34335	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
SMD44_RS34430	COG3383	formate dehydrogenase (NAD+) activity
SMD44_RS34435	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SMD44_RS34440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMD44_RS34470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMD44_RS34480	COG1940	carbohydrate kinase activity
SMD44_RS34485	COG1129	ABC transporter
SMD44_RS34490	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMD44_RS34500	COG0673	inositol 2-dehydrogenase activity
SMD44_RS34525	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SMD44_RS34565	COG2223	nitrite transmembrane transporter activity
SMD44_RS34585	COG0045	succinate-CoA ligase (ADP-forming) activity
SMD44_RS34595	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS34690	COG1472	Belongs to the glycosyl hydrolase 3 family
SMD44_RS34695	COG1063	alcohol dehydrogenase
SMD44_RS34700	COG0673	inositol 2-dehydrogenase activity
SMD44_RS34745	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SMD44_RS34755	COG4948	Mandelate Racemase Muconate Lactonizing
SMD44_RS34760	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SMD44_RS34795	COG3246	L-lysine catabolic process to acetate
SMD44_RS34800	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMD44_RS34810	COG1486	melibiose metabolic process
SMD44_RS34830	COG3511	phospholipase C
SMD44_RS34835	COG0525	valine-tRNA ligase activity
SMD44_RS34865	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SMD44_RS34870	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS34875	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS34885	COG1309	transcriptional regulator
SMD44_RS34890	COG0183	Belongs to the thiolase family
SMD44_RS34895	COG1672	PFAM Archaeal ATPase
SMD44_RS34895	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SMD44_RS34915	COG1024	Enoyl-CoA hydratase
SMD44_RS34925	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS34940	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SMD44_RS34945	COG3485	protocatechuate 3,4-dioxygenase
SMD44_RS34950	COG3485	protocatechuate 3,4-dioxygenase
SMD44_RS34965	COG1846	Transcriptional regulator
SMD44_RS34980	COG1793	dna ligase
SMD44_RS35070	COG1515	deoxyribonuclease V activity
SMD44_RS35075	COG3268	Saccharopine dehydrogenase
SMD44_RS35085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SMD44_RS35090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD44_RS35095	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS35100	COG0183	Belongs to the thiolase family
SMD44_RS35105	COG1024	Enoyl-CoA hydratase
SMD44_RS35105	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMD44_RS35110	COG0789	Transcriptional regulator
SMD44_RS35120	COG1113	amino acid transport
SMD44_RS35135	COG2936	dipeptidyl-peptidase activity
SMD44_RS35145	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SMD44_RS35160	COG0488	(ABC) transporter
SMD44_RS35250	COG1388	LysM domain
SMD44_RS35250	COG1134	teichoic acid transport
SMD44_RS35255	COG1562	ergosterol biosynthetic process
SMD44_RS35265	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SMD44_RS35275	COG1657	PFAM Prenyltransferase squalene oxidase
SMD44_RS35290	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SMD44_RS35295	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SMD44_RS35325	COG2755	lipolytic protein G-D-S-L family
SMD44_RS35345	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SMD44_RS35365	COG0494	nUDIX hydrolase
SMD44_RS35720	COG0583	DNA-binding transcription factor activity
SMD44_RS35725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SMD44_RS35735	COG1116	anion transmembrane transporter activity
SMD44_RS35760	COG2267	carboxylic ester hydrolase activity
SMD44_RS35775	COG3958	Transketolase
SMD44_RS35780	COG3959	Transketolase, thiamine diphosphate binding domain
SMD44_RS35815	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SMD44_RS35830	COG3903	Transcriptional regulator
SMD44_RS35830	COG3629	intracellular signal transduction
SMD44_RS35875	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SMD44_RS35880	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SMD44_RS35885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMD44_RS35905	COG2409	Drug exporters of the RND superfamily
SMD44_RS35915	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SMD44_RS35920	COG0248	Ppx GppA phosphatase
SMD44_RS35935	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SMD44_RS35950	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD44_RS35955	COG0156	8-amino-7-oxononanoate synthase activity
SMD44_RS35960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMD44_RS35965	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMD44_RS35970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMD44_RS35980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMD44_RS36005	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS36010	COG3321	synthase
SMD44_RS36010	COG3321	synthase
SMD44_RS36015	COG3629	intracellular signal transduction
SMD44_RS36035	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SMD44_RS36040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMD44_RS36040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMD44_RS36045	COG0668	transmembrane transport
SMD44_RS36080	COG1175	transmembrane transport
SMD44_RS36085	COG0395	ABC-type sugar transport system, permease component
SMD44_RS36100	COG4249	Peptidase C14 caspase catalytic subunit p20
SMD44_RS36100	COG2319	Wd-40 repeat
SMD44_RS36105	COG2340	Cysteine-rich secretory protein family
SMD44_RS36115	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS36175	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SMD44_RS36185	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SMD44_RS36185	COG0512	Glutamine amidotransferase of anthranilate synthase
SMD44_RS36195	COG2124	cytochrome p450
SMD44_RS36205	COG3321	synthase
SMD44_RS36205	COG0604	alcohol dehydrogenase
SMD44_RS36230	COG3321	synthase
SMD44_RS36230	COG0604	alcohol dehydrogenase
SMD44_RS36240	COG3321	synthase
SMD44_RS36240	COG0604	alcohol dehydrogenase
SMD44_RS36245	COG3321	synthase
SMD44_RS36245	COG0604	alcohol dehydrogenase
SMD44_RS36325	COG1595	DNA-templated transcription, initiation
SMD44_RS36355	COG0154	amidase activity
SMD44_RS36365	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS36395	COG2130	NADP-dependent
SMD44_RS36415	COG1132	(ABC) transporter
SMD44_RS36430	COG2814	Major facilitator Superfamily
SMD44_RS36450	COG0463	Glycosyl transferase, family 2
SMD44_RS36480	COG1131	(ABC) transporter
SMD44_RS36510	COG0604	alcohol dehydrogenase
SMD44_RS36510	COG3321	synthase
SMD44_RS36510	COG0604	alcohol dehydrogenase
SMD44_RS36510	COG3321	synthase
SMD44_RS36600	COG0318	PFAM AMP-dependent synthetase and ligase
SMD44_RS36610	COG2124	cytochrome p450
SMD44_RS36635	COG4585	Histidine kinase
SMD44_RS36645	COG4585	Histidine kinase
SMD44_RS36660	COG2409	Drug exporters of the RND superfamily
SMD44_RS36705	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SMD44_RS36730	COG0297	glycogen (starch) synthase activity
SMD44_RS36735	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SMD44_RS36740	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMD44_RS36745	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMD44_RS36750	COG1129	ABC transporter
SMD44_RS36755	COG1879	ABC-type sugar transport system periplasmic component
SMD44_RS36760	COG1609	Transcriptional regulator
SMD44_RS36770	COG3537	Alpha-1,2-mannosidase
SMD44_RS36825	COG1609	Transcriptional regulator
SMD44_RS36830	COG1653	transport
SMD44_RS36835	COG1175	transmembrane transport
SMD44_RS36840	COG0395	ABC-type sugar transport system, permease component
SMD44_RS36855	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SMD44_RS36880	COG1129	ABC transporter
SMD44_RS36890	COG4948	Mandelate Racemase Muconate Lactonizing
SMD44_RS36895	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS36915	COG3152	Membrane
SMD44_RS36925	COG2197	response regulator
SMD44_RS36930	COG4585	Histidine kinase
SMD44_RS36935	COG1131	(ABC) transporter
SMD44_RS36965	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SMD44_RS36995	COG0531	amino acid
SMD44_RS37005	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SMD44_RS37005	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SMD44_RS37010	COG0726	polysaccharide deacetylase
SMD44_RS37075	COG1053	succinate dehydrogenase
SMD44_RS37095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD44_RS37105	COG1733	regulation of RNA biosynthetic process
SMD44_RS37110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMD44_RS37135	COG2755	lipolytic protein G-D-S-L family
SMD44_RS37135	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SMD44_RS37140	COG0745	RESPONSE REGULATOR receiver
SMD44_RS37145	COG2205	protein histidine kinase activity
SMD44_RS37170	COG2182	Extracellular solute-binding protein
SMD44_RS37175	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SMD44_RS37180	COG0121	glutamine amidotransferase
SMD44_RS37185	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SMD44_RS37210	COG1609	Transcriptional regulator
SMD44_RS37215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMD44_RS37230	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SMD44_RS37305	COG0842	Transport permease protein
SMD44_RS37305	COG1129	ABC transporter
SMD44_RS37405	COG1733	regulation of RNA biosynthetic process
SMD44_RS37470	COG2084	Dehydrogenase
SMD44_RS37475	COG1733	regulation of RNA biosynthetic process
SMD44_RS37505	COG0546	phosphoglycolate phosphatase activity
SMD44_RS37510	COG2264	protein methyltransferase activity
SMD44_RS37575	COG1335	isochorismatase
SMD44_RS37595	COG0517	IMP dehydrogenase activity
SMD44_RS37605	COG0789	Transcriptional regulator
SMD44_RS37610	COG2318	DinB family
SMD44_RS37615	COG0318	PFAM AMP-dependent synthetase and ligase
SMD44_RS37635	COG1316	TRANSCRIPTIONal
SMD44_RS37665	COG1100	Small GTP-binding protein
SMD44_RS37680	COG0542	response to heat
SMD44_RS37690	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SMD44_RS37705	COG4245	von Willebrand factor, type A
SMD44_RS37740	COG0596	Alpha beta hydrolase
SMD44_RS37775	COG0745	RESPONSE REGULATOR receiver
SMD44_RS37780	COG2205	protein histidine kinase activity
SMD44_RS37785	COG0583	DNA-binding transcription factor activity
SMD44_RS37800	COG1309	transcriptional regulator
SMD44_RS37835	COG3409	Peptidoglycan-binding domain 1 protein
SMD44_RS37885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMD44_RS37900	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMD44_RS37920	COG0366	Alpha amylase catalytic
SMD44_RS37925	COG0395	ABC-type sugar transport system, permease component
SMD44_RS37930	COG1175	transmembrane transport
SMD44_RS37970	COG1174	glycine betaine transport
SMD44_RS37995	COG1139	Iron-sulfur cluster binding protein
SMD44_RS38000	COG0247	lactate metabolic process
SMD44_RS38015	COG1024	Enoyl-CoA hydratase
SMD44_RS38020	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS38065	COG4608	Belongs to the ABC transporter superfamily
SMD44_RS38070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMD44_RS38100	COG1070	Carbohydrate kinase
SMD44_RS38105	COG0588	phosphoglycerate mutase activity
SMD44_RS38160	COG4044	May play a role in the intracellular transport of hydrophobic ligands
SMD44_RS38185	COG3845	ABC transporter
SMD44_RS38205	COG3568	Endonuclease Exonuclease Phosphatase
SMD44_RS38225	COG1595	DNA-templated transcription, initiation
SMD44_RS38270	COG1271	oxidase subunit
SMD44_RS38275	COG0583	DNA-binding transcription factor activity
SMD44_RS38295	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SMD44_RS38310	COG2319	Wd-40 repeat
SMD44_RS38310	COG4249	Peptidase C14 caspase catalytic subunit p20
SMD44_RS38325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD44_RS38335	COG1120	ATPase activity
SMD44_RS38340	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
SMD44_RS38400	COG1132	(ABC) transporter
SMD44_RS38465	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SMD44_RS38470	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
SMD44_RS38480	COG0463	Glycosyl transferase, family 2
SMD44_RS38480	COG1216	Glycosyl transferase, family 2
SMD44_RS38505	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SMD44_RS38515	COG0438	transferase activity, transferring glycosyl groups
SMD44_RS38555	COG0438	transferase activity, transferring glycosyl groups
SMD44_RS38565	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SMD44_RS38575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD44_RS38580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD44_RS38590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD44_RS38660	COG1408	metallophosphoesterase
SMD44_RS38680	COG2226	methyltransferase
SMD44_RS38695	COG0309	Hydrogenase expression formation protein (HypE)
SMD44_RS38700	COG0409	Hydrogenase expression formation protein
SMD44_RS38790	COG1652	LysM domain
SMD44_RS38800	COG0071	Belongs to the small heat shock protein (HSP20) family
SMD44_RS38825	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SMD44_RS38885	COG0589	response to stress
SMD44_RS38910	COG4249	Peptidase C14 caspase catalytic subunit p20
SMD44_RS38910	COG2319	Wd-40 repeat
SMD44_RS38940	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SMD44_RS38945	COG1454	alcohol dehydrogenase
SMD44_RS38945	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS38960	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS39005	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SMD44_RS39085	COG2018	Roadblock/LC7 domain
SMD44_RS39100	COG1946	Acyl-CoA thioesterase
SMD44_RS39125	COG1301	dicarboxylic acid transport
SMD44_RS39130	COG0473	3-isopropylmalate dehydrogenase activity
SMD44_RS39170	COG1846	Transcriptional regulator
SMD44_RS39210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD44_RS39225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SMD44_RS39275	COG1088	dTDP-glucose 4,6-dehydratase activity
SMD44_RS39290	COG0515	serine threonine protein kinase
SMD44_RS39320	COG0318	PFAM AMP-dependent synthetase and ligase
SMD44_RS39325	COG1132	(ABC) transporter
SMD44_RS39330	COG2986	histidine ammonia-lyase
SMD44_RS39340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMD44_RS39425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD44_RS39430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD44_RS39450	COG1022	Amp-dependent synthetase and ligase
SMD44_RS39475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD44_RS39480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD44_RS39485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD44_RS39490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD44_RS39495	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD44_RS39500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD44_RS39505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD44_RS39525	COG2080	2 iron, 2 sulfur cluster binding
SMD44_RS39540	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SMD44_RS39540	COG3608	succinylglutamate desuccinylase aspartoacylase
SMD44_RS39580	COG1126	abc transporter atp-binding protein
SMD44_RS39595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD44_RS39650	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SMD44_RS39660	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SMD44_RS39675	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SMD44_RS39695	COG0747	negative chemotaxis
SMD44_RS39700	COG0515	serine threonine protein kinase
SMD44_RS39750	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SMD44_RS39760	COG2040	homocysteine
SMD44_RS39770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMD44_RS39780	COG0747	negative chemotaxis
SMD44_RS39785	COG1940	carbohydrate kinase activity
SMD44_RS39845	COG1902	pentaerythritol trinitrate reductase activity
SMD44_RS39850	COG0640	Transcriptional regulator
SMD44_RS39900	COG2197	response regulator
SMD44_RS39910	COG3540	Alkaline phosphatase
SMD44_RS39930	COG0740	serine-type endopeptidase activity
SMD44_RS39935	COG0740	serine-type endopeptidase activity
SMD44_RS39945	COG1396	sequence-specific DNA binding
SMD44_RS39990	COG2188	Transcriptional regulator
SMD44_RS40075	COG1802	Transcriptional regulator
SMD44_RS40080	COG1846	Transcriptional regulator
SMD44_RS40090	COG4214	carbohydrate transport
SMD44_RS40120	COG1414	Transcriptional regulator
SMD44_RS40175	COG3485	protocatechuate 3,4-dioxygenase
SMD44_RS40180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD44_RS40250	COG1191	sigma factor activity
SMD44_RS40350	COG2340	Cysteine-rich secretory protein family
SMD44_RS40405	COG1472	Belongs to the glycosyl hydrolase 3 family
SMD44_RS40430	COG0494	nUDIX hydrolase
SMD44_RS40445	COG0483	inositol monophosphate 1-phosphatase activity
SMD44_RS40520	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
SMD44_RS40565	COG1120	ATPase activity
SMD44_RS40605	COG0142	geranyltranstransferase activity
SMD44_RS40625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD44_RS40630	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS40635	COG1169	isochorismate synthase
SMD44_RS40645	COG3433	isochorismatase activity
SMD44_RS40645	COG1535	isochorismatase
SMD44_RS40650	COG1535	isochorismatase
SMD44_RS40650	COG3433	isochorismatase activity
SMD44_RS40680	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SMD44_RS40690	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
SMD44_RS40780	COG1595	DNA-templated transcription, initiation
SMD44_RS40830	COG4977	sequence-specific DNA binding
SMD44_RS40840	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS40845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMD44_RS40885	COG0477	Major facilitator Superfamily
SMD44_RS40915	COG0009	L-threonylcarbamoyladenylate synthase
SMD44_RS40925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMD44_RS40925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMD44_RS41030	COG0745	RESPONSE REGULATOR receiver
SMD44_RS41045	COG1136	(ABC) transporter
SMD44_RS41045	COG0577	efflux transmembrane transporter activity
SMD44_RS41070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SMD44_RS41120	COG0515	serine threonine protein kinase
SMD44_RS41150	COG4585	Histidine kinase
SMD44_RS41170	COG0302	gtp cyclohydrolase
SMD44_RS41175	COG0517	IMP dehydrogenase activity
SMD44_RS41175	COG0516	GMP reductase activity
SMD44_RS41180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SMD44_RS41255	COG1140	nitrate reductase beta subunit
SMD44_RS41290	COG0583	DNA-binding transcription factor activity
SMD44_RS41345	COG1132	(ABC) transporter
SMD44_RS41375	COG0542	response to heat
SMD44_RS41395	COG0189	ligase activity
SMD44_RS41435	COG1309	transcriptional regulator
SMD44_RS41460	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SMD44_RS41500	COG0488	(ABC) transporter
SMD44_RS41570	COG0515	serine threonine protein kinase
SMD44_RS41580	COG1132	(ABC) transporter
SMD44_RS41585	COG1132	(ABC) transporter
SMD44_RS41610	COG2197	response regulator
SMD44_RS41675	COG0745	RESPONSE REGULATOR receiver
SMD44_RS41780	COG0326	Molecular chaperone. Has ATPase activity
SMD44_RS41790	COG2124	cytochrome p450
SMD44_RS41810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD44_RS41825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD44_RS41845	COG3251	PFAM MbtH domain protein
SMD44_RS41895	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity