locus-tag	class	description
SMD44_RS00090	COG0242	peptide deformylase activity
SMD44_RS00190	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS00200	COG0028	Belongs to the TPP enzyme family
SMD44_RS00230	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SMD44_RS00260	COG3903	Transcriptional regulator
SMD44_RS00260	COG3629	intracellular signal transduction
SMD44_RS00280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SMD44_RS00295	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
SMD44_RS00300	COG4948	Mandelate Racemase Muconate Lactonizing
SMD44_RS00335	COG1921	L-seryl-tRNASec selenium transferase activity
SMD44_RS00345	COG0667	Aldo Keto reductase
SMD44_RS00365	COG2197	response regulator
SMD44_RS00370	COG4585	Histidine kinase
SMD44_RS00375	COG2132	Multicopper oxidase
SMD44_RS00465	COG1234	tRNA 3'-trailer cleavage
SMD44_RS00540	COG1595	DNA-templated transcription, initiation
SMD44_RS00575	COG0702	epimerase
SMD44_RS00580	COG1309	transcriptional regulator
SMD44_RS00625	COG2197	response regulator
SMD44_RS00630	COG4585	Histidine kinase
SMD44_RS00635	COG2409	Drug exporters of the RND superfamily
SMD44_RS00645	COG0488	(ABC) transporter
SMD44_RS00660	COG0402	S-adenosylhomocysteine deaminase activity
SMD44_RS00670	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS00675	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
SMD44_RS00680	COG2318	DinB family
SMD44_RS00690	COG1309	transcriptional regulator
SMD44_RS00700	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SMD44_RS00720	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMD44_RS00730	COG1595	DNA-templated transcription, initiation
SMD44_RS00745	COG1231	oxidoreductase activity
SMD44_RS00770	COG0596	Alpha beta hydrolase
SMD44_RS00770	COG2945	thiolester hydrolase activity
SMD44_RS00775	COG1309	transcriptional regulator
SMD44_RS00785	COG3321	synthase
SMD44_RS00785	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS00785	COG0604	alcohol dehydrogenase
SMD44_RS00800	COG2319	Wd-40 repeat
SMD44_RS00800	COG4249	Peptidase C14 caspase catalytic subunit p20
SMD44_RS00810	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SMD44_RS00820	COG3903	Transcriptional regulator
SMD44_RS00820	COG3629	intracellular signal transduction
SMD44_RS00835	COG0604	alcohol dehydrogenase
SMD44_RS00850	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SMD44_RS00905	COG2197	response regulator
SMD44_RS00945	COG0745	RESPONSE REGULATOR receiver
SMD44_RS00960	COG3708	Transcriptional regulator
SMD44_RS00960	COG2207	Transcriptional regulator
SMD44_RS01030	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SMD44_RS01035	COG2079	MmgE PrpD family protein
SMD44_RS01040	COG1396	sequence-specific DNA binding
SMD44_RS01040	COG3800	Transcriptional regulator
SMD44_RS01055	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SMD44_RS01065	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMD44_RS01075	COG1780	Probably involved in ribonucleotide reductase function
SMD44_RS01080	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMD44_RS01090	COG0301	tRNA thio-modification
SMD44_RS01095	COG1051	belongs to the nudix hydrolase family
SMD44_RS01100	COG3896	Chloramphenicol phosphotransferase-like protein
SMD44_RS01105	COG4977	sequence-specific DNA binding
SMD44_RS01115	COG0515	serine threonine protein kinase
SMD44_RS01115	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMD44_RS01140	COG2318	DinB family
SMD44_RS01155	COG0667	Aldo Keto reductase
SMD44_RS01165	COG1819	glycosyl
SMD44_RS01170	COG2972	Histidine kinase
SMD44_RS01170	COG2205	protein histidine kinase activity
SMD44_RS01210	COG2814	Major facilitator Superfamily
SMD44_RS01230	COG2205	protein histidine kinase activity
SMD44_RS01235	COG0745	RESPONSE REGULATOR receiver
SMD44_RS01250	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SMD44_RS01255	COG1169	isochorismate synthase
SMD44_RS01260	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS01270	COG1078	dGTPase activity
SMD44_RS01295	COG1846	Transcriptional regulator
SMD44_RS01340	COG2376	Dihydroxyacetone kinase
SMD44_RS01360	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SMD44_RS01365	COG4585	Histidine kinase
SMD44_RS01450	COG2272	Belongs to the type-B carboxylesterase lipase family
SMD44_RS01455	COG1309	transcriptional regulator
SMD44_RS01475	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD44_RS01480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD44_RS01490	COG2375	cellular response to nickel ion
SMD44_RS01510	COG0395	ABC-type sugar transport system, permease component
SMD44_RS01520	COG1609	Transcriptional regulator
SMD44_RS01555	COG0148	phosphopyruvate hydratase activity
SMD44_RS01580	COG2340	Cysteine-rich secretory protein family
SMD44_RS01590	COG2186	Transcriptional regulator
SMD44_RS01610	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS01640	COG0640	Transcriptional regulator
SMD44_RS01645	COG2814	Major facilitator Superfamily
SMD44_RS01665	COG0667	Aldo Keto reductase
SMD44_RS01670	COG4552	Acetyltransferase involved in intracellular survival and related
SMD44_RS01700	COG1132	(ABC) transporter
SMD44_RS01720	COG2207	Transcriptional regulator
SMD44_RS01740	COG1309	transcriptional regulator
SMD44_RS01745	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS01750	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SMD44_RS01750	COG1796	DNA polymerase
SMD44_RS01800	COG4948	Mandelate Racemase Muconate Lactonizing
SMD44_RS01860	COG1024	Enoyl-CoA hydratase
SMD44_RS01870	COG2226	methyltransferase
SMD44_RS01875	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SMD44_RS01895	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS01905	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMD44_RS01910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMD44_RS01925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMD44_RS01945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMD44_RS01980	COG3629	intracellular signal transduction
SMD44_RS01980	COG3903	Transcriptional regulator
SMD44_RS02005	COG0745	RESPONSE REGULATOR receiver
SMD44_RS02015	COG1686	Belongs to the peptidase S11 family
SMD44_RS02040	COG2066	Belongs to the glutaminase family
SMD44_RS02045	COG1486	melibiose metabolic process
SMD44_RS02050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMD44_RS02055	COG0395	ABC-type sugar transport system, permease component
SMD44_RS02085	COG0778	Nitroreductase
SMD44_RS02115	COG0583	DNA-binding transcription factor activity
SMD44_RS02150	COG4221	oxidoreductase activity
SMD44_RS02165	COG1309	transcriptional regulator
SMD44_RS02180	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS02210	COG2124	cytochrome p450
SMD44_RS02235	COG0789	Transcriptional regulator
SMD44_RS02260	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
SMD44_RS02260	COG3408	Glycogen debranching enzyme
SMD44_RS02275	COG3321	synthase
SMD44_RS02275	COG0604	alcohol dehydrogenase
SMD44_RS02280	COG3321	synthase
SMD44_RS02280	COG0604	alcohol dehydrogenase
SMD44_RS02285	COG3321	synthase
SMD44_RS02285	COG0604	alcohol dehydrogenase
SMD44_RS02315	COG0657	acetylesterase activity
SMD44_RS02350	COG3622	Belongs to the hyi family
SMD44_RS02395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMD44_RS02440	COG0697	spore germination
SMD44_RS02485	COG0789	Transcriptional regulator
SMD44_RS02500	COG0477	Major facilitator Superfamily
SMD44_RS02505	COG1957	nucleoside hydrolase
SMD44_RS02510	COG1609	Transcriptional regulator
SMD44_RS02520	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SMD44_RS02525	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
SMD44_RS02545	COG1131	(ABC) transporter
SMD44_RS02550	COG2259	Doxx family
SMD44_RS02565	COG2124	cytochrome p450
SMD44_RS02640	COG2197	response regulator
SMD44_RS02645	COG4585	Histidine kinase
SMD44_RS02650	COG0789	Transcriptional regulator
SMD44_RS02660	COG1335	isochorismatase
SMD44_RS02665	COG1349	DNA-binding transcription factor activity
SMD44_RS02675	COG0191	fructose-bisphosphate aldolase activity
SMD44_RS02710	COG1132	(ABC) transporter
SMD44_RS02725	COG2267	carboxylic ester hydrolase activity
SMD44_RS02730	COG1940	carbohydrate kinase activity
SMD44_RS02735	COG2182	Extracellular solute-binding protein
SMD44_RS02740	COG1175	transmembrane transport
SMD44_RS02745	COG0395	ABC-type sugar transport system, permease component
SMD44_RS02750	COG2723	6-phospho-beta-galactosidase activity
SMD44_RS02790	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS02795	COG3938	Belongs to the proline racemase family
SMD44_RS02830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMD44_RS02835	COG0601	transmembrane transport
SMD44_RS02845	COG4608	Belongs to the ABC transporter superfamily
SMD44_RS02850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMD44_RS02855	COG0667	Aldo Keto reductase
SMD44_RS02875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD44_RS02890	COG3973	AAA domain
SMD44_RS02920	COG1309	transcriptional regulator
SMD44_RS02965	COG2706	6-phosphogluconolactonase activity
SMD44_RS02980	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SMD44_RS03010	COG0386	Belongs to the glutathione peroxidase family
SMD44_RS03035	COG0673	inositol 2-dehydrogenase activity
SMD44_RS03040	COG1132	(ABC) transporter
SMD44_RS03040	COG2375	cellular response to nickel ion
SMD44_RS03060	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SMD44_RS03060	COG0825	malonyl-CoA metabolic process
SMD44_RS03065	COG1793	dna ligase
SMD44_RS03095	COG0181	hydroxymethylbilane synthase activity
SMD44_RS03100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD44_RS03125	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SMD44_RS03130	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SMD44_RS03135	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SMD44_RS03140	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMD44_RS03145	COG2197	response regulator
SMD44_RS03150	COG1733	regulation of RNA biosynthetic process
SMD44_RS03160	COG1131	(ABC) transporter
SMD44_RS03170	COG4585	Histidine kinase
SMD44_RS03220	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMD44_RS03230	COG1940	carbohydrate kinase activity
SMD44_RS03230	COG1846	Transcriptional regulator
SMD44_RS03270	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SMD44_RS03275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMD44_RS03295	COG2124	cytochrome p450
SMD44_RS03360	COG3486	L-lysine 6-monooxygenase (NADPH) activity
SMD44_RS03365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMD44_RS03365	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SMD44_RS03405	COG1024	Enoyl-CoA hydratase
SMD44_RS03435	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS03450	COG0583	DNA-binding transcription factor activity
SMD44_RS03455	COG0318	PFAM AMP-dependent synthetase and ligase
SMD44_RS03460	COG2366	antibiotic biosynthetic process
SMD44_RS03470	COG2070	2-Nitropropane dioxygenase
SMD44_RS03480	COG4948	Mandelate Racemase Muconate Lactonizing
SMD44_RS03485	COG1414	Transcriptional regulator
SMD44_RS03510	COG0515	serine threonine protein kinase
SMD44_RS03555	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS03570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMD44_RS03635	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SMD44_RS03655	COG1131	(ABC) transporter
SMD44_RS03690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMD44_RS03695	COG0747	negative chemotaxis
SMD44_RS03700	COG0601	transmembrane transport
SMD44_RS03710	COG4608	Belongs to the ABC transporter superfamily
SMD44_RS03720	COG1595	DNA-templated transcription, initiation
SMD44_RS03745	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMD44_RS03775	COG2376	Dihydroxyacetone kinase
SMD44_RS03810	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS03880	COG0446	pyridine nucleotide-disulphide oxidoreductase
SMD44_RS03880	COG1902	pentaerythritol trinitrate reductase activity
SMD44_RS03895	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMD44_RS03920	COG2813	Specifically methylates the guanine in position
SMD44_RS03990	COG1349	DNA-binding transcription factor activity
SMD44_RS04015	COG0577	efflux transmembrane transporter activity
SMD44_RS04020	COG1136	(ABC) transporter
SMD44_RS04065	COG1940	carbohydrate kinase activity
SMD44_RS04095	COG4249	Peptidase C14 caspase catalytic subunit p20
SMD44_RS04095	COG2319	Wd-40 repeat
SMD44_RS04125	COG2197	response regulator
SMD44_RS04130	COG4585	Histidine kinase
SMD44_RS04135	COG0445	tRNA wobble uridine modification
SMD44_RS04150	COG2197	response regulator
SMD44_RS04155	COG4585	Histidine kinase
SMD44_RS04170	COG1660	Displays ATPase and GTPase activities
SMD44_RS04185	COG4585	Histidine kinase
SMD44_RS04325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMD44_RS04330	COG0438	transferase activity, transferring glycosyl groups
SMD44_RS04640	COG0305	Participates in initiation and elongation during chromosome replication
SMD44_RS04645	COG1484	DNA-dependent DNA replication
SMD44_RS04680	COG3723	Recombinational DNA repair protein, rece pathway
SMD44_RS04745	COG3617	BRO family, N-terminal domain
SMD44_RS04770	COG0395	ABC-type sugar transport system, permease component
SMD44_RS04785	COG3345	alpha-galactosidase
SMD44_RS04790	COG3903	Transcriptional regulator
SMD44_RS04790	COG3629	intracellular signal transduction
SMD44_RS04830	COG0515	serine threonine protein kinase
SMD44_RS04845	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SMD44_RS04865	COG0204	Acyl-transferase
SMD44_RS04900	COG0657	acetylesterase activity
SMD44_RS04905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD44_RS04920	COG0584	glycerophosphoryl diester phosphodiesterase
SMD44_RS04955	COG0671	phosphoesterase, PA-phosphatase related
SMD44_RS04970	COG1309	transcriptional regulator
SMD44_RS04985	COG2964	Protein conserved in bacteria
SMD44_RS05000	COG2186	Transcriptional regulator
SMD44_RS05005	COG2807	transmembrane transport
SMD44_RS05025	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SMD44_RS05050	COG0745	RESPONSE REGULATOR receiver
SMD44_RS05065	COG4941	Belongs to the sigma-70 factor family
SMD44_RS05120	COG0247	lactate metabolic process
SMD44_RS05120	COG0277	FAD linked oxidase domain protein
SMD44_RS05125	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SMD44_RS05130	COG1414	Transcriptional regulator
SMD44_RS05150	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS05195	COG2409	Drug exporters of the RND superfamily
SMD44_RS05210	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SMD44_RS05220	COG2890	protein-(glutamine-N5) methyltransferase activity
SMD44_RS05250	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SMD44_RS05255	COG1937	Protein conserved in bacteria
SMD44_RS05270	COG0277	FAD linked oxidase domain protein
SMD44_RS05290	COG0366	Alpha amylase catalytic
SMD44_RS05295	COG3833	ABC-type maltose transport systems, permease component
SMD44_RS05305	COG2182	Extracellular solute-binding protein
SMD44_RS05310	COG1609	Transcriptional regulator
SMD44_RS05315	COG0640	Transcriptional regulator
SMD44_RS05320	COG1116	anion transmembrane transporter activity
SMD44_RS05340	COG3384	dioxygenase
SMD44_RS05380	COG0330	HflC and HflK could
SMD44_RS05420	COG2084	Dehydrogenase
SMD44_RS05455	COG2175	clavaminate synthase activity
SMD44_RS05495	COG2815	serine threonine protein kinase
SMD44_RS05495	COG0515	serine threonine protein kinase
SMD44_RS05510	COG4941	Belongs to the sigma-70 factor family
SMD44_RS05525	COG0367	asparagine synthase
SMD44_RS05535	COG0697	spore germination
SMD44_RS05555	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMD44_RS05580	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS05590	COG0242	peptide deformylase activity
SMD44_RS05600	COG3442	glutamine amidotransferase
SMD44_RS05605	COG0205	6-phosphofructokinase activity
SMD44_RS05620	COG0204	Acyl-transferase
SMD44_RS05630	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SMD44_RS05730	COG0829	nickel cation binding
SMD44_RS05735	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SMD44_RS05745	COG0804	urea catabolic process
SMD44_RS05750	COG0832	Belongs to the urease beta subunit family
SMD44_RS05755	COG0831	urea catabolic process
SMD44_RS05760	COG1309	transcriptional regulator
SMD44_RS05775	COG0740	serine-type endopeptidase activity
SMD44_RS05795	COG1280	lysine exporter protein (LysE YggA)
SMD44_RS05820	COG0156	8-amino-7-oxononanoate synthase activity
SMD44_RS05825	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SMD44_RS05830	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SMD44_RS05835	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SMD44_RS05840	COG2226	methyltransferase
SMD44_RS05865	COG1136	(ABC) transporter
SMD44_RS05865	COG0577	efflux transmembrane transporter activity
SMD44_RS05870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD44_RS05890	COG0583	DNA-binding transcription factor activity
SMD44_RS05925	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SMD44_RS05930	COG0586	Pfam SNARE associated Golgi protein
SMD44_RS05940	COG4585	Histidine kinase
SMD44_RS05970	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SMD44_RS06000	COG1024	Enoyl-CoA hydratase
SMD44_RS06020	COG4585	Histidine kinase
SMD44_RS06025	COG2197	response regulator
SMD44_RS06030	COG1940	carbohydrate kinase activity
SMD44_RS06035	COG2188	Transcriptional regulator
SMD44_RS06040	COG1595	DNA-templated transcription, initiation
SMD44_RS06065	COG1309	transcriptional regulator
SMD44_RS06075	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS06090	COG1522	sequence-specific DNA binding
SMD44_RS06095	COG0419	ATPase involved in DNA repair
SMD44_RS06100	COG0420	3'-5' exonuclease activity
SMD44_RS06130	COG1739	Uncharacterized protein family UPF0029
SMD44_RS06165	COG1832	CoA-binding protein
SMD44_RS06190	COG2205	protein histidine kinase activity
SMD44_RS06250	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SMD44_RS06270	COG0110	maltose O-acetyltransferase activity
SMD44_RS06295	COG2272	Belongs to the type-B carboxylesterase lipase family
SMD44_RS06340	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SMD44_RS06355	COG1968	undecaprenyl-diphosphatase activity
SMD44_RS06400	COG1309	transcriptional regulator
SMD44_RS06405	COG0477	Major facilitator Superfamily
SMD44_RS06420	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SMD44_RS06425	COG0673	inositol 2-dehydrogenase activity
SMD44_RS06450	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SMD44_RS06455	COG0747	negative chemotaxis
SMD44_RS06505	COG0697	spore germination
SMD44_RS06545	COG2890	protein-(glutamine-N5) methyltransferase activity
SMD44_RS06560	COG0384	phenazine biosynthesis protein PhzF
SMD44_RS06590	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SMD44_RS06590	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SMD44_RS06600	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SMD44_RS06640	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SMD44_RS06675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SMD44_RS06685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMD44_RS06700	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SMD44_RS06715	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SMD44_RS06720	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SMD44_RS06755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SMD44_RS06765	COG1414	Transcriptional regulator
SMD44_RS06780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMD44_RS06810	COG2814	Major facilitator Superfamily
SMD44_RS06815	COG4336	lyase activity
SMD44_RS06820	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SMD44_RS06825	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SMD44_RS06830	COG1984	allophanate hydrolase subunit 2
SMD44_RS06840	COG0438	transferase activity, transferring glycosyl groups
SMD44_RS06870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMD44_RS06875	COG2364	Membrane
SMD44_RS06895	COG3030	protein affecting phage T7 exclusion by the F plasmid
SMD44_RS06900	COG0463	Glycosyl transferase, family 2
SMD44_RS06935	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS06945	COG1309	transcriptional regulator
SMD44_RS07000	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SMD44_RS07005	COG0140	phosphoribosyl-ATP diphosphatase activity
SMD44_RS07010	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SMD44_RS07015	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SMD44_RS07015	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SMD44_RS07020	COG3201	nicotinamide mononucleotide transporter
SMD44_RS07050	COG0738	Major facilitator superfamily
SMD44_RS07060	COG2233	PERMEase
SMD44_RS07080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMD44_RS07095	COG0531	amino acid
SMD44_RS07130	COG2124	cytochrome p450
SMD44_RS07145	COG2124	cytochrome p450
SMD44_RS07165	COG2390	Transcriptional regulator
SMD44_RS07170	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SMD44_RS07175	COG2409	Drug exporters of the RND superfamily
SMD44_RS07180	COG4941	Belongs to the sigma-70 factor family
SMD44_RS07185	COG3795	YCII-related domain
SMD44_RS07205	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SMD44_RS07215	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SMD44_RS07220	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SMD44_RS07235	COG0194	GDP metabolic process
SMD44_RS07245	COG0284	orotidine-5'-phosphate decarboxylase activity
SMD44_RS07250	COG0167	dihydroorotate dehydrogenase activity
SMD44_RS07255	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SMD44_RS07260	COG0505	Belongs to the CarA family
SMD44_RS07270	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SMD44_RS07275	COG0540	Belongs to the ATCase OTCase family
SMD44_RS07280	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SMD44_RS07290	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMD44_RS07295	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SMD44_RS07300	COG0006	proline dipeptidase activity
SMD44_RS07315	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SMD44_RS07320	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SMD44_RS07325	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SMD44_RS07330	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SMD44_RS07335	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SMD44_RS07340	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SMD44_RS07345	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SMD44_RS07365	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SMD44_RS07390	COG4585	Histidine kinase
SMD44_RS07395	COG2197	response regulator
SMD44_RS07400	COG0124	histidyl-tRNA synthetase
SMD44_RS07410	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SMD44_RS07415	COG1196	nuclear chromosome segregation
SMD44_RS07420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SMD44_RS07430	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SMD44_RS07435	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SMD44_RS07445	COG2255	four-way junction helicase activity
SMD44_RS07450	COG0632	four-way junction helicase activity
SMD44_RS07460	COG0217	transcriptional regulatory protein
SMD44_RS07465	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SMD44_RS07470	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SMD44_RS07485	COG0438	transferase activity, transferring glycosyl groups
SMD44_RS07490	COG1560	Kdo2-lipid A biosynthetic process
SMD44_RS07495	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SMD44_RS07520	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SMD44_RS07535	COG2176	DNA-directed DNA polymerase activity
SMD44_RS07535	COG5002	protein histidine kinase activity
SMD44_RS07595	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SMD44_RS07655	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SMD44_RS07655	COG1648	precorrin-2 dehydrogenase activity
SMD44_RS07660	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SMD44_RS07675	COG1464	Belongs to the NlpA lipoprotein family
SMD44_RS07680	COG1464	Belongs to the NlpA lipoprotein family
SMD44_RS07685	COG2011	ABC-type metal ion transport system permease component
SMD44_RS07690	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SMD44_RS07720	COG0584	glycerophosphoryl diester phosphodiesterase
SMD44_RS07725	COG0318	PFAM AMP-dependent synthetase and ligase
SMD44_RS07725	COG0204	Acyl-transferase
SMD44_RS07730	COG0477	Major facilitator Superfamily
SMD44_RS07745	COG0165	Argininosuccinate lyase
SMD44_RS07750	COG0137	argininosuccinate synthase activity
SMD44_RS07775	COG0385	Bile acid
SMD44_RS07780	COG0326	Molecular chaperone. Has ATPase activity
SMD44_RS07785	COG1438	arginine binding
SMD44_RS07790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMD44_RS07795	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SMD44_RS07800	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SMD44_RS07805	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SMD44_RS07810	COG2838	Isocitrate dehydrogenase
SMD44_RS07815	COG0789	Transcriptional regulator
SMD44_RS07830	COG0667	Aldo Keto reductase
SMD44_RS07855	COG0697	spore germination
SMD44_RS07865	COG1649	PFAM Uncharacterised BCR, COG1649
SMD44_RS07895	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMD44_RS07895	COG0072	phenylalanine-tRNA ligase activity
SMD44_RS07900	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SMD44_RS07905	COG5002	protein histidine kinase activity
SMD44_RS07910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SMD44_RS07915	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SMD44_RS07920	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SMD44_RS07925	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SMD44_RS07965	COG0560	Phosphoserine phosphatase
SMD44_RS07965	COG3830	Belongs to the UPF0237 family
SMD44_RS07975	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS07980	COG0174	glutamine synthetase
SMD44_RS07990	COG0531	amino acid
SMD44_RS07995	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SMD44_RS08010	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SMD44_RS08020	COG4176	ABC-type proline glycine betaine transport system permease component
SMD44_RS08025	COG4175	Glycine betaine
SMD44_RS08025	COG0517	IMP dehydrogenase activity
SMD44_RS08030	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMD44_RS08045	COG0564	pseudouridine synthase activity
SMD44_RS08085	COG0805	protein transport
SMD44_RS08090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SMD44_RS08125	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SMD44_RS08135	COG1609	Transcriptional regulator
SMD44_RS08140	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SMD44_RS08145	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SMD44_RS08160	COG4122	O-methyltransferase activity
SMD44_RS08165	COG1222	aaa ATPase
SMD44_RS08190	COG0517	IMP dehydrogenase activity
SMD44_RS08190	COG1994	Peptidase M50
SMD44_RS08200	COG2197	response regulator
SMD44_RS08205	COG4166	transmembrane transport
SMD44_RS08210	COG0747	negative chemotaxis
SMD44_RS08220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMD44_RS08225	COG0646	methionine synthase
SMD44_RS08225	COG1410	methionine synthase
SMD44_RS08230	COG1414	Transcriptional regulator
SMD44_RS08235	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SMD44_RS08240	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SMD44_RS08245	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SMD44_RS08260	COG0402	S-adenosylhomocysteine deaminase activity
SMD44_RS08265	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SMD44_RS08275	COG2186	Transcriptional regulator
SMD44_RS08295	COG0215	cysteine-tRNA ligase activity
SMD44_RS08310	COG0406	alpha-ribazole phosphatase activity
SMD44_RS08315	COG0598	Magnesium transport protein CorA
SMD44_RS08325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD44_RS08330	COG0667	Aldo Keto reductase
SMD44_RS08365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMD44_RS08430	COG0753	catalase activity
SMD44_RS08435	COG3012	SEC-C Motif Domain Protein
SMD44_RS08450	COG3265	gluconokinase activity
SMD44_RS08465	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SMD44_RS08480	COG3573	Dehydrogenase
SMD44_RS08485	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SMD44_RS08490	COG2149	membrane
SMD44_RS08515	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS08525	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS08570	COG0789	Transcriptional regulator
SMD44_RS08585	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS08615	COG2851	Citrate transporter
SMD44_RS08620	COG0243	molybdopterin cofactor binding
SMD44_RS08630	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
SMD44_RS08635	COG2188	Transcriptional regulator
SMD44_RS08645	COG0477	Major facilitator Superfamily
SMD44_RS08660	COG2197	response regulator
SMD44_RS08670	COG5343	regulation of RNA biosynthetic process
SMD44_RS08675	COG1595	DNA-templated transcription, initiation
SMD44_RS08700	COG2755	lipolytic protein G-D-S-L family
SMD44_RS08715	COG0463	Glycosyl transferase, family 2
SMD44_RS08745	COG1725	Transcriptional regulator
SMD44_RS08790	COG4565	transcriptional regulatory protein
SMD44_RS08800	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
SMD44_RS08820	COG0587	DNA-directed DNA polymerase activity
SMD44_RS08835	COG2197	response regulator
SMD44_RS08840	COG4585	Histidine kinase
SMD44_RS08845	COG2409	Drug exporters of the RND superfamily
SMD44_RS08860	COG1454	alcohol dehydrogenase
SMD44_RS08860	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS08875	COG3227	Zinc metalloprotease (Elastase)
SMD44_RS08890	COG4166	transmembrane transport
SMD44_RS08895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMD44_RS08920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD44_RS08930	COG0765	amino acid transport
SMD44_RS08935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMD44_RS08945	COG1799	cell septum assembly
SMD44_RS08950	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS08955	COG0477	Major facilitator Superfamily
SMD44_RS08965	COG0671	phosphoesterase, PA-phosphatase related
SMD44_RS08975	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SMD44_RS08985	COG0438	transferase activity, transferring glycosyl groups
SMD44_RS09015	COG3583	domain protein
SMD44_RS09020	COG1652	LysM domain
SMD44_RS09035	COG1160	GTP binding
SMD44_RS09045	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SMD44_RS09085	COG3541	Predicted nucleotidyltransferase
SMD44_RS09090	COG1187	pseudouridine synthase activity
SMD44_RS09095	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SMD44_RS09100	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SMD44_RS09115	COG0686	Belongs to the AlaDH PNT family
SMD44_RS09125	COG0494	nUDIX hydrolase
SMD44_RS09130	COG0504	CTP synthase activity
SMD44_RS09135	COG3387	PFAM Glycoside hydrolase 15-related
SMD44_RS09145	COG0438	transferase activity, transferring glycosyl groups
SMD44_RS09155	COG0497	DNA recombination
SMD44_RS09165	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SMD44_RS09185	COG1120	ATPase activity
SMD44_RS09190	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD44_RS09195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD44_RS09215	COG0647	UMP catabolic process
SMD44_RS09255	COG2094	Belongs to the DNA glycosylase MPG family
SMD44_RS09265	COG1881	PFAM PEBP family protein
SMD44_RS09285	COG1119	ATPase activity
SMD44_RS09305	COG2197	response regulator
SMD44_RS09320	COG0842	Transport permease protein
SMD44_RS09320	COG1131	(ABC) transporter
SMD44_RS09320	COG1716	ATPase activity
SMD44_RS09330	COG3830	Belongs to the UPF0237 family
SMD44_RS09330	COG0560	Phosphoserine phosphatase
SMD44_RS09355	COG2186	Transcriptional regulator
SMD44_RS09370	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS09385	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SMD44_RS09405	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SMD44_RS09410	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SMD44_RS09420	COG1404	Belongs to the peptidase S8 family
SMD44_RS09425	COG1404	Belongs to the peptidase S8 family
SMD44_RS09485	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SMD44_RS09500	COG3387	PFAM Glycoside hydrolase 15-related
SMD44_RS09550	COG0488	(ABC) transporter
SMD44_RS09575	COG0235	Class ii aldolase
SMD44_RS09605	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SMD44_RS09625	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SMD44_RS09630	COG1797	cobyrinic acid a,c-diamide synthase activity
SMD44_RS09680	COG3119	arylsulfatase activity
SMD44_RS09690	COG1104	cysteine desulfurase activity
SMD44_RS09695	COG0456	acetyltransferase
SMD44_RS09700	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SMD44_RS09705	COG1917	Cupin 2, conserved barrel domain protein
SMD44_RS09710	COG5285	phytanoyl-CoA dioxygenase
SMD44_RS09715	COG1902	pentaerythritol trinitrate reductase activity
SMD44_RS09720	COG1846	Transcriptional regulator
SMD44_RS09725	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SMD44_RS09735	COG1733	regulation of RNA biosynthetic process
SMD44_RS09755	COG1414	Transcriptional regulator
SMD44_RS09765	COG4585	Histidine kinase
SMD44_RS09770	COG2197	response regulator
SMD44_RS09775	COG0768	penicillin binding
SMD44_RS09785	COG1695	Transcriptional regulator
SMD44_RS09825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMD44_RS09830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMD44_RS09840	COG1349	DNA-binding transcription factor activity
SMD44_RS09855	COG0395	ABC-type sugar transport system, permease component
SMD44_RS09860	COG1063	alcohol dehydrogenase
SMD44_RS09890	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS09930	COG2329	Antibiotic biosynthesis monooxygenase
SMD44_RS09940	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMD44_RS09950	COG1595	DNA-templated transcription, initiation
SMD44_RS09960	COG2171	N-acyltransferase activity
SMD44_RS09975	COG3226	Transcriptional regulator
SMD44_RS09980	COG2076	Multidrug Resistance protein
SMD44_RS09990	COG0822	iron-sulfur transferase activity
SMD44_RS09995	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SMD44_RS10000	COG0396	ATPase activity
SMD44_RS10010	COG0719	Fe-S assembly protein
SMD44_RS10025	COG2746	aminoglycoside 3-N-acetyltransferase activity
SMD44_RS10030	COG1131	(ABC) transporter
SMD44_RS10040	COG1612	heme a metabolic process
SMD44_RS10060	COG0109	protoheme IX farnesyltransferase activity
SMD44_RS10070	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SMD44_RS10085	COG0363	glucosamine-6-phosphate deaminase activity
SMD44_RS10095	COG0166	Belongs to the GPI family
SMD44_RS10110	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SMD44_RS10115	COG0149	triose-phosphate isomerase activity
SMD44_RS10120	COG0126	phosphoglycerate kinase activity
SMD44_RS10125	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SMD44_RS10135	COG1481	regulation of sporulation
SMD44_RS10140	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SMD44_RS10145	COG1660	Displays ATPase and GTPase activities
SMD44_RS10185	COG2353	YceI-like domain
SMD44_RS10190	COG1024	Enoyl-CoA hydratase
SMD44_RS10195	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SMD44_RS10210	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SMD44_RS10215	COG1619	proteins homologs of microcin C7 resistance protein MccF
SMD44_RS10220	COG0477	Major facilitator Superfamily
SMD44_RS10225	COG0387	Pfam Sodium calcium exchanger
SMD44_RS10255	COG0584	glycerophosphoryl diester phosphodiesterase
SMD44_RS10260	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMD44_RS10275	COG2313	pseudouridylate synthase activity
SMD44_RS10280	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SMD44_RS10280	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SMD44_RS10285	COG2226	methyltransferase
SMD44_RS10290	COG0598	Magnesium transport protein CorA
SMD44_RS10355	COG2124	cytochrome p450
SMD44_RS10360	COG0402	S-adenosylhomocysteine deaminase activity
SMD44_RS10395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SMD44_RS10435	COG2267	carboxylic ester hydrolase activity
SMD44_RS10440	COG1288	antiporter activity
SMD44_RS10475	COG0237	dephospho-CoA kinase activity
SMD44_RS10495	COG2226	methyltransferase
SMD44_RS10500	COG1643	Atp-dependent helicase
SMD44_RS10525	COG2050	protein possibly involved in aromatic compounds catabolism
SMD44_RS10535	COG0559	Belongs to the binding-protein-dependent transport system permease family
SMD44_RS10575	COG0737	Belongs to the 5'-nucleotidase family
SMD44_RS10605	COG0287	Prephenate dehydrogenase
SMD44_RS10605	COG1605	Chorismate mutase
SMD44_RS10620	COG0366	Alpha amylase catalytic
SMD44_RS10620	COG1470	cell adhesion involved in biofilm formation
SMD44_RS10625	COG3851	Histidine kinase
SMD44_RS10630	COG2197	response regulator
SMD44_RS10645	COG0513	Belongs to the DEAD box helicase family
SMD44_RS10650	COG1278	Cold shock
SMD44_RS10655	COG0477	Major facilitator Superfamily
SMD44_RS10660	COG1846	Transcriptional regulator
SMD44_RS10665	COG2365	Tyrosine phosphatase family
SMD44_RS10675	COG2267	carboxylic ester hydrolase activity
SMD44_RS10690	COG0395	ABC-type sugar transport system, permease component
SMD44_RS10695	COG1175	transmembrane transport
SMD44_RS10710	COG0070	glutamate synthase
SMD44_RS10710	COG0067	glutamate synthase
SMD44_RS10710	COG0069	glutamate synthase activity
SMD44_RS10740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMD44_RS10745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SMD44_RS10755	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SMD44_RS10765	COG0159	tryptophan synthase activity
SMD44_RS10770	COG0133	tryptophan synthase activity
SMD44_RS10780	COG0134	indole-3-glycerol-phosphate synthase activity
SMD44_RS10805	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SMD44_RS10830	COG0107	imidazoleglycerol-phosphate synthase activity
SMD44_RS10835	COG0251	oxidation-reduction process
SMD44_RS10840	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SMD44_RS10845	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SMD44_RS10850	COG0131	Imidazoleglycerol-phosphate dehydratase
SMD44_RS10855	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMD44_RS10860	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SMD44_RS10880	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SMD44_RS10900	COG1432	Conserved Protein
SMD44_RS10910	COG0587	DNA-directed DNA polymerase activity
SMD44_RS10935	COG0515	serine threonine protein kinase
SMD44_RS10965	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SMD44_RS10985	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SMD44_RS11000	COG1799	cell septum assembly
SMD44_RS11010	COG1496	oxidoreductase activity
SMD44_RS11015	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SMD44_RS11030	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SMD44_RS11040	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SMD44_RS11045	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMD44_RS11055	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SMD44_RS11070	COG0275	rRNA processing
SMD44_RS11080	COG0714	Associated with various cellular activities
SMD44_RS11100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SMD44_RS11110	COG0842	Transport permease protein
SMD44_RS11110	COG1131	(ABC) transporter
SMD44_RS11110	COG1716	ATPase activity
SMD44_RS11120	COG1309	transcriptional regulator
SMD44_RS11145	COG0352	thiamine-phosphate diphosphorylase activity
SMD44_RS11160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMD44_RS11160	COG2022	thiamine diphosphate biosynthetic process
SMD44_RS11170	COG2022	thiamine diphosphate biosynthetic process
SMD44_RS11175	COG2815	serine threonine protein kinase
SMD44_RS11175	COG0515	serine threonine protein kinase
SMD44_RS11180	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SMD44_RS11185	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SMD44_RS11190	COG2193	ferroxidase activity
SMD44_RS11195	COG0243	molybdopterin cofactor binding
SMD44_RS11200	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SMD44_RS11220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SMD44_RS11225	COG0205	6-phosphofructokinase activity
SMD44_RS11230	COG2197	response regulator
SMD44_RS11235	COG4585	Histidine kinase
SMD44_RS11260	COG1940	carbohydrate kinase activity
SMD44_RS11270	COG0003	Pfam Anion-transporting ATPase
SMD44_RS11290	COG0438	transferase activity, transferring glycosyl groups
SMD44_RS11340	COG2205	protein histidine kinase activity
SMD44_RS11345	COG0745	RESPONSE REGULATOR receiver
SMD44_RS11355	COG1929	Belongs to the glycerate kinase type-1 family
SMD44_RS11360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SMD44_RS11365	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SMD44_RS11370	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SMD44_RS11375	COG0723	plastoquinol--plastocyanin reductase activity
SMD44_RS11380	COG2010	Cytochrome c
SMD44_RS11385	COG1845	cytochrome c oxidase, subunit III
SMD44_RS11395	COG1376	ErfK ybiS ycfS ynhG family protein
SMD44_RS11405	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SMD44_RS11410	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SMD44_RS11415	COG1104	cysteine desulfurase activity
SMD44_RS11420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMD44_RS11440	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SMD44_RS11445	COG2197	response regulator
SMD44_RS11450	COG4585	Histidine kinase
SMD44_RS11475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMD44_RS11495	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SMD44_RS11500	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SMD44_RS11500	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SMD44_RS11515	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SMD44_RS11520	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SMD44_RS11525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SMD44_RS11530	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMD44_RS11540	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SMD44_RS11560	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS11605	COG0321	lipoyl(octanoyl) transferase activity
SMD44_RS11610	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SMD44_RS11635	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
SMD44_RS11660	COG0590	tRNA wobble adenosine to inosine editing
SMD44_RS11680	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SMD44_RS11685	COG0640	Transcriptional regulator
SMD44_RS11690	COG2226	methyltransferase
SMD44_RS11710	COG1120	ATPase activity
SMD44_RS11715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD44_RS11770	COG0745	RESPONSE REGULATOR receiver
SMD44_RS11780	COG2409	Drug exporters of the RND superfamily
SMD44_RS11785	COG4585	Histidine kinase
SMD44_RS11790	COG2197	response regulator
SMD44_RS11830	COG1309	transcriptional regulator
SMD44_RS11840	COG0366	Alpha amylase catalytic
SMD44_RS11845	COG1609	Transcriptional regulator
SMD44_RS11855	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SMD44_RS11870	COG0174	glutamine synthetase
SMD44_RS11895	COG4209	transmembrane transport
SMD44_RS11900	COG0395	ABC-type sugar transport system, permease component
SMD44_RS11910	COG1609	Transcriptional regulator
SMD44_RS11930	COG0531	amino acid
SMD44_RS11940	COG2132	Multicopper oxidase
SMD44_RS11950	COG2814	Major facilitator Superfamily
SMD44_RS11965	COG0477	Major facilitator Superfamily
SMD44_RS11970	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SMD44_RS11990	COG1994	Peptidase M50
SMD44_RS12050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SMD44_RS12060	COG1120	ATPase activity
SMD44_RS12085	COG1834	amidinotransferase
SMD44_RS12095	COG2814	Major facilitator Superfamily
SMD44_RS12110	COG3540	Alkaline phosphatase
SMD44_RS12115	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS12125	COG0384	phenazine biosynthesis protein PhzF
SMD44_RS12180	COG0475	glutathione-regulated potassium exporter activity
SMD44_RS12215	COG0557	exoribonuclease II activity
SMD44_RS12220	COG3022	response to hydroperoxide
SMD44_RS12225	COG0800	Aldolase
SMD44_RS12240	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SMD44_RS12245	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SMD44_RS12260	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS12270	COG2030	dehydratase
SMD44_RS12275	COG4585	Histidine kinase
SMD44_RS12280	COG2197	response regulator
SMD44_RS12290	COG0183	Belongs to the thiolase family
SMD44_RS12315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD44_RS12365	COG0438	transferase activity, transferring glycosyl groups
SMD44_RS12370	COG1309	transcriptional regulator
SMD44_RS12420	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS12425	COG1657	PFAM Prenyltransferase squalene oxidase
SMD44_RS12440	COG3845	ABC transporter
SMD44_RS12455	COG0183	Belongs to the thiolase family
SMD44_RS12460	COG2124	cytochrome p450
SMD44_RS12480	COG4122	O-methyltransferase activity
SMD44_RS12590	COG4977	sequence-specific DNA binding
SMD44_RS12640	COG0800	Aldolase
SMD44_RS12660	COG1358	cellular component organization or biogenesis
SMD44_RS12710	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SMD44_RS12715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMD44_RS12735	COG0667	Aldo Keto reductase
SMD44_RS12740	COG0789	Transcriptional regulator
SMD44_RS12755	COG1741	Belongs to the pirin family
SMD44_RS12770	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMD44_RS12775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMD44_RS12780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMD44_RS12805	COG0583	DNA-binding transcription factor activity
SMD44_RS12825	COG1764	response to oxidative stress
SMD44_RS12830	COG2130	NADP-dependent
SMD44_RS12870	COG4981	capsule polysaccharide biosynthetic process
SMD44_RS12925	COG1215	transferase activity, transferring glycosyl groups
SMD44_RS12930	COG0318	PFAM AMP-dependent synthetase and ligase
SMD44_RS12945	COG0535	radical SAM domain protein
SMD44_RS12960	COG1404	Belongs to the peptidase S8 family
SMD44_RS13000	COG1077	Cell shape determining protein MreB Mrl
SMD44_RS13025	COG3585	molybdate ion transport
SMD44_RS13045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD44_RS13050	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SMD44_RS13110	COG1857	crispr-associated protein
SMD44_RS13225	COG1316	TRANSCRIPTIONal
SMD44_RS13250	COG3594	Acyltransferase
SMD44_RS13305	COG1070	Carbohydrate kinase
SMD44_RS13330	COG0358	DNA primase activity
SMD44_RS13340	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SMD44_RS13355	COG0243	molybdopterin cofactor binding
SMD44_RS13380	COG2205	protein histidine kinase activity
SMD44_RS13415	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SMD44_RS13420	COG2146	nitrite reductase [NAD(P)H] activity
SMD44_RS13420	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SMD44_RS13430	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS13445	COG0531	amino acid
SMD44_RS13475	COG0574	Belongs to the PEP-utilizing enzyme family
SMD44_RS13475	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SMD44_RS13480	COG1940	carbohydrate kinase activity
SMD44_RS13480	COG1846	Transcriptional regulator
SMD44_RS13505	COG0477	Major facilitator Superfamily
SMD44_RS13510	COG0477	Major facilitator Superfamily
SMD44_RS13515	COG0667	Aldo Keto reductase
SMD44_RS13535	COG0423	glycine-tRNA ligase activity
SMD44_RS13540	COG0803	Belongs to the bacterial solute-binding protein 9 family
SMD44_RS13540	COG3443	Belongs to the bacterial solute-binding protein 9 family
SMD44_RS13545	COG1121	(ABC) transporter
SMD44_RS13550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SMD44_RS13560	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SMD44_RS13565	COG1381	Involved in DNA repair and RecF pathway recombination
SMD44_RS13610	COG3629	intracellular signal transduction
SMD44_RS13610	COG3903	Transcriptional regulator
SMD44_RS13620	COG3631	Ketosteroid isomerase-related protein
SMD44_RS13625	COG0702	epimerase
SMD44_RS13635	COG2186	Transcriptional regulator
SMD44_RS13640	COG0747	negative chemotaxis
SMD44_RS13650	COG0444	Belongs to the ABC transporter superfamily
SMD44_RS13655	COG4608	Belongs to the ABC transporter superfamily
SMD44_RS13660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMD44_RS13670	COG2197	response regulator
SMD44_RS13675	COG4585	Histidine kinase
SMD44_RS13680	COG2409	Drug exporters of the RND superfamily
SMD44_RS13690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMD44_RS13710	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SMD44_RS13730	COG2315	Protein conserved in bacteria
SMD44_RS13740	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SMD44_RS13750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMD44_RS13755	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SMD44_RS13760	COG1234	tRNA 3'-trailer cleavage
SMD44_RS13765	COG0537	adenosine 5'-monophosphoramidase activity
SMD44_RS13770	COG4946	Tricorn protease homolog
SMD44_RS13770	COG0793	Belongs to the peptidase S41A family
SMD44_RS13790	COG2070	2-Nitropropane dioxygenase
SMD44_RS13795	COG0484	heat shock protein binding
SMD44_RS13800	COG1420	regulation of RNA biosynthetic process
SMD44_RS13825	COG3850	Histidine kinase
SMD44_RS13825	COG3437	response regulator, receiver
SMD44_RS13825	COG2205	protein histidine kinase activity
SMD44_RS13825	COG4999	Histidine kinase
SMD44_RS13840	COG0481	GTPase activity
SMD44_RS13845	COG0268	Binds directly to 16S ribosomal RNA
SMD44_RS13860	COG2353	YceI-like domain
SMD44_RS13870	COG1555	photosystem II stabilization
SMD44_RS13875	COG1307	EDD domain protein, DegV family
SMD44_RS13885	COG0495	leucyl-tRNA aminoacylation
SMD44_RS13895	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SMD44_RS13905	COG1051	belongs to the nudix hydrolase family
SMD44_RS13915	COG0477	Major facilitator Superfamily
SMD44_RS13930	COG0588	phosphoglycerate mutase activity
SMD44_RS13935	COG0799	negative regulation of ribosome biogenesis
SMD44_RS13945	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SMD44_RS13960	COG0501	Belongs to the peptidase M48B family
SMD44_RS13975	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SMD44_RS13985	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SMD44_RS13995	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SMD44_RS14000	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SMD44_RS14005	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SMD44_RS14015	COG1530	ribonuclease E activity
SMD44_RS14045	COG0772	Belongs to the SEDS family
SMD44_RS14065	COG1077	Cell shape determining protein MreB Mrl
SMD44_RS14070	COG0105	UTP biosynthetic process
SMD44_RS14080	COG0285	dihydrofolate synthase activity
SMD44_RS14085	COG1077	Cell shape determining protein MreB Mrl
SMD44_RS14090	COG4585	Histidine kinase
SMD44_RS14100	COG2205	protein histidine kinase activity
SMD44_RS14120	COG0525	valine-tRNA ligase activity
SMD44_RS14140	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SMD44_RS14145	COG0740	serine-type endopeptidase activity
SMD44_RS14150	COG0740	serine-type endopeptidase activity
SMD44_RS14155	COG0544	peptidyl-prolyl cis-trans isomerase activity
SMD44_RS14170	COG0515	serine threonine protein kinase
SMD44_RS14170	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMD44_RS14180	COG3594	Acyltransferase
SMD44_RS14195	COG1136	(ABC) transporter
SMD44_RS14195	COG0577	efflux transmembrane transporter activity
SMD44_RS14205	COG4552	Acetyltransferase involved in intracellular survival and related
SMD44_RS14225	COG1113	amino acid transport
SMD44_RS14235	COG1268	BioY protein
SMD44_RS14240	COG1113	amino acid transport
SMD44_RS14245	COG1113	amino acid transport
SMD44_RS14250	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SMD44_RS14255	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SMD44_RS14325	COG2814	Major facilitator Superfamily
SMD44_RS14330	COG0583	DNA-binding transcription factor activity
SMD44_RS14385	COG1116	anion transmembrane transporter activity
SMD44_RS14385	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SMD44_RS14390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SMD44_RS14395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SMD44_RS14420	COG0697	spore germination
SMD44_RS14425	COG1846	Transcriptional regulator
SMD44_RS14450	COG0668	transmembrane transport
SMD44_RS14455	COG1940	carbohydrate kinase activity
SMD44_RS14455	COG1846	Transcriptional regulator
SMD44_RS14460	COG1653	transport
SMD44_RS14465	COG1175	transmembrane transport
SMD44_RS14470	COG0395	ABC-type sugar transport system, permease component
SMD44_RS14475	COG1486	melibiose metabolic process
SMD44_RS14490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMD44_RS14520	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SMD44_RS14545	COG0456	acetyltransferase
SMD44_RS14620	COG0629	single-stranded DNA binding
SMD44_RS14670	COG1022	Amp-dependent synthetase and ligase
SMD44_RS14675	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SMD44_RS14675	COG4106	trans-aconitate 2-methyltransferase activity
SMD44_RS14680	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SMD44_RS14695	COG1131	(ABC) transporter
SMD44_RS14700	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SMD44_RS14715	COG3962	Belongs to the TPP enzyme family
SMD44_RS14720	COG3718	enzyme involved in inositol metabolism
SMD44_RS14730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMD44_RS14735	COG1082	Xylose isomerase domain protein TIM barrel
SMD44_RS14765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SMD44_RS14770	COG1609	Transcriptional regulator
SMD44_RS14775	COG1129	ABC transporter
SMD44_RS14780	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMD44_RS14785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMD44_RS14790	COG1869	D-ribose catabolic process
SMD44_RS14810	COG0673	inositol 2-dehydrogenase activity
SMD44_RS14815	COG1609	Transcriptional regulator
SMD44_RS14840	COG1846	Transcriptional regulator
SMD44_RS14840	COG0456	acetyltransferase
SMD44_RS14850	COG0789	Transcriptional regulator
SMD44_RS14865	COG1472	Belongs to the glycosyl hydrolase 3 family
SMD44_RS14895	COG0028	Belongs to the TPP enzyme family
SMD44_RS14905	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SMD44_RS14935	COG1946	Acyl-CoA thioesterase
SMD44_RS14945	COG1309	transcriptional regulator
SMD44_RS14950	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SMD44_RS14965	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS14980	COG3486	L-lysine 6-monooxygenase (NADPH) activity
SMD44_RS15010	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMD44_RS15015	COG0589	response to stress
SMD44_RS15025	COG4977	sequence-specific DNA binding
SMD44_RS15030	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
SMD44_RS15105	COG0588	phosphoglycerate mutase activity
SMD44_RS15155	COG0583	DNA-binding transcription factor activity
SMD44_RS15165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD44_RS15185	COG0154	amidase activity
SMD44_RS15200	COG0765	amino acid transport
SMD44_RS15205	COG0765	amino acid transport
SMD44_RS15210	COG1126	abc transporter atp-binding protein
SMD44_RS15230	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SMD44_RS15240	COG0512	Glutamine amidotransferase of anthranilate synthase
SMD44_RS15250	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SMD44_RS15265	COG4585	Histidine kinase
SMD44_RS15270	COG2197	response regulator
SMD44_RS15275	COG2409	Drug exporters of the RND superfamily
SMD44_RS15285	COG2197	response regulator
SMD44_RS15290	COG4585	Histidine kinase
SMD44_RS15295	COG0318	PFAM AMP-dependent synthetase and ligase
SMD44_RS15300	COG3397	chitin binding
SMD44_RS15325	COG2186	Transcriptional regulator
SMD44_RS15405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMD44_RS15410	COG2188	Transcriptional regulator
SMD44_RS15425	COG0673	inositol 2-dehydrogenase activity
SMD44_RS15430	COG4702	Belongs to the UPF0303 family
SMD44_RS15440	COG0179	Fumarylacetoacetate (FAA) hydrolase
SMD44_RS15445	COG0706	membrane insertase activity
SMD44_RS15465	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SMD44_RS15475	COG3764	Sortase (surface protein transpeptidase)
SMD44_RS15535	COG4977	sequence-specific DNA binding
SMD44_RS15540	COG2271	Major facilitator Superfamily
SMD44_RS15545	COG2733	membrane
SMD44_RS15560	COG4555	ABC transporter
SMD44_RS15600	COG0477	Major facilitator Superfamily
SMD44_RS15610	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SMD44_RS15620	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SMD44_RS15625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMD44_RS15630	COG1263	PTS System
SMD44_RS15635	COG1263	PTS System
SMD44_RS15640	COG1234	tRNA 3'-trailer cleavage
SMD44_RS15660	COG1120	ATPase activity
SMD44_RS15665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD44_RS15680	COG1113	amino acid transport
SMD44_RS15685	COG1115	amino acid carrier protein
SMD44_RS15695	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SMD44_RS15705	COG1335	isochorismatase
SMD44_RS15740	COG0277	FAD linked oxidase domain protein
SMD44_RS15750	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SMD44_RS15760	COG1174	glycine betaine transport
SMD44_RS15770	COG1174	glycine betaine transport
SMD44_RS15900	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SMD44_RS15910	COG2814	Major facilitator Superfamily
SMD44_RS15915	COG0583	DNA-binding transcription factor activity
SMD44_RS15920	COG1678	Uncharacterized ACR, COG1678
SMD44_RS15925	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SMD44_RS15930	COG0776	regulation of translation
SMD44_RS15940	COG3973	AAA domain
SMD44_RS15970	COG2223	nitrite transmembrane transporter activity
SMD44_RS16020	COG0583	DNA-binding transcription factor activity
SMD44_RS16030	COG2027	D-alanyl-D-alanine carboxypeptidase
SMD44_RS16040	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SMD44_RS16045	COG0793	Belongs to the peptidase S41A family
SMD44_RS16055	COG2884	Cell division ATP-binding protein ftsE
SMD44_RS16070	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SMD44_RS16075	COG0515	serine threonine protein kinase
SMD44_RS16080	COG0515	serine threonine protein kinase
SMD44_RS16085	COG1674	ftsk spoiiie
SMD44_RS16095	COG1175	transmembrane transport
SMD44_RS16100	COG0395	ABC-type sugar transport system, permease component
SMD44_RS16115	COG0438	transferase activity, transferring glycosyl groups
SMD44_RS16120	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SMD44_RS16125	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SMD44_RS16135	COG1215	transferase activity, transferring glycosyl groups
SMD44_RS16150	COG1136	(ABC) transporter
SMD44_RS16160	COG2197	response regulator
SMD44_RS16180	COG1134	teichoic acid transport
SMD44_RS16185	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SMD44_RS16190	COG1215	transferase activity, transferring glycosyl groups
SMD44_RS16215	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SMD44_RS16230	COG1216	Glycosyl transferase, family 2
SMD44_RS16235	COG2902	Dehydrogenase
SMD44_RS16260	COG0653	protein targeting
SMD44_RS16270	COG3214	Protein conserved in bacteria
SMD44_RS16275	COG2197	response regulator
SMD44_RS16280	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SMD44_RS16290	COG0823	Involved in the tonB-independent uptake of proteins
SMD44_RS16295	COG5002	protein histidine kinase activity
SMD44_RS16300	COG0745	RESPONSE REGULATOR receiver
SMD44_RS16305	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SMD44_RS16325	COG0714	Associated with various cellular activities
SMD44_RS16370	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SMD44_RS16375	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMD44_RS16375	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMD44_RS16375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMD44_RS16385	COG1482	cell wall glycoprotein biosynthetic process
SMD44_RS16395	COG2835	tetraacyldisaccharide 4'-kinase activity
SMD44_RS16400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMD44_RS16405	COG1620	l-lactate permease
SMD44_RS16440	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SMD44_RS16445	COG0778	Nitroreductase
SMD44_RS16445	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
SMD44_RS16470	COG1316	TRANSCRIPTIONal
SMD44_RS16475	COG1316	TRANSCRIPTIONal
SMD44_RS16490	COG1316	TRANSCRIPTIONal
SMD44_RS16505	COG1316	TRANSCRIPTIONal
SMD44_RS16525	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SMD44_RS16565	COG0745	RESPONSE REGULATOR receiver
SMD44_RS16570	COG3104	oligopeptide transport
SMD44_RS16605	COG1366	Belongs to the anti-sigma-factor antagonist family
SMD44_RS16610	COG1191	sigma factor activity
SMD44_RS16615	COG1228	amidohydrolase
SMD44_RS16630	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SMD44_RS16640	COG0583	DNA-binding transcription factor activity
SMD44_RS16690	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
SMD44_RS16695	COG0288	reversible hydration of carbon dioxide
SMD44_RS16710	COG2755	lipolytic protein G-D-S-L family
SMD44_RS16715	COG0183	Belongs to the thiolase family
SMD44_RS16755	COG1136	(ABC) transporter
SMD44_RS16760	COG0577	efflux transmembrane transporter activity
SMD44_RS16765	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SMD44_RS16790	COG0148	phosphopyruvate hydratase activity
SMD44_RS16875	COG0577	efflux transmembrane transporter activity
SMD44_RS16880	COG1136	(ABC) transporter
SMD44_RS16895	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SMD44_RS16925	COG4585	Histidine kinase
SMD44_RS16945	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SMD44_RS16950	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SMD44_RS16955	COG0193	aminoacyl-tRNA hydrolase activity
SMD44_RS16975	COG1309	transcriptional regulator
SMD44_RS16985	COG4106	trans-aconitate 2-methyltransferase activity
SMD44_RS16990	COG1846	Transcriptional regulator
SMD44_RS16995	COG2197	response regulator
SMD44_RS17025	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SMD44_RS17050	COG0488	(ABC) transporter
SMD44_RS17060	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SMD44_RS17080	COG0084	hydrolase, TatD family'
SMD44_RS17110	COG0442	prolyl-tRNA aminoacylation
SMD44_RS17175	COG1122	ATPase activity
SMD44_RS17185	COG0310	cobalt ion transport
SMD44_RS17195	COG2409	Drug exporters of the RND superfamily
SMD44_RS17215	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS17220	COG2267	carboxylic ester hydrolase activity
SMD44_RS17225	COG2072	flavoprotein involved in K transport
SMD44_RS17240	COG0708	Exodeoxyribonuclease III
SMD44_RS17250	COG2205	protein histidine kinase activity
SMD44_RS17260	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SMD44_RS17285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMD44_RS17290	COG0521	Mo-molybdopterin cofactor biosynthetic process
SMD44_RS17295	COG0315	cyclic pyranopterin monophosphate synthase activity
SMD44_RS17305	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SMD44_RS17310	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SMD44_RS17315	COG2366	antibiotic biosynthetic process
SMD44_RS17335	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SMD44_RS17355	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SMD44_RS17375	COG1376	ErfK ybiS ycfS ynhG family protein
SMD44_RS17395	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
SMD44_RS17395	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMD44_RS17395	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMD44_RS17405	COG1349	DNA-binding transcription factor activity
SMD44_RS17410	COG0477	Major facilitator Superfamily
SMD44_RS17430	COG1846	Transcriptional regulator
SMD44_RS17450	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SMD44_RS17525	COG2076	Multidrug Resistance protein
SMD44_RS17530	COG0590	tRNA wobble adenosine to inosine editing
SMD44_RS17580	COG0110	maltose O-acetyltransferase activity
SMD44_RS17590	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMD44_RS17590	COG4499	WXG100 protein secretion system (Wss), protein YukC
SMD44_RS17610	COG1653	transport
SMD44_RS17620	COG1686	Belongs to the peptidase S11 family
SMD44_RS17740	COG0346	lactoylglutathione lyase activity
SMD44_RS17780	COG1396	sequence-specific DNA binding
SMD44_RS17800	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SMD44_RS17815	COG0640	Transcriptional regulator
SMD44_RS17830	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SMD44_RS17855	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS17860	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SMD44_RS17885	COG3629	intracellular signal transduction
SMD44_RS17885	COG3903	Transcriptional regulator
SMD44_RS17925	COG1024	Enoyl-CoA hydratase
SMD44_RS17930	COG0515	serine threonine protein kinase
SMD44_RS17930	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMD44_RS17940	COG1309	transcriptional regulator
SMD44_RS17970	COG0259	pyridoxamine-phosphate oxidase activity
SMD44_RS17990	COG2072	flavoprotein involved in K transport
SMD44_RS18000	COG1024	Enoyl-CoA hydratase
SMD44_RS18070	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS18090	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS18095	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS18100	COG0318	PFAM AMP-dependent synthetase and ligase
SMD44_RS18165	COG1131	(ABC) transporter
SMD44_RS18200	COG0577	efflux transmembrane transporter activity
SMD44_RS18205	COG1136	(ABC) transporter
SMD44_RS18220	COG0745	RESPONSE REGULATOR receiver
SMD44_RS18225	COG2205	protein histidine kinase activity
SMD44_RS18230	COG4821	SIS domain
SMD44_RS18240	COG0596	Alpha beta hydrolase
SMD44_RS18240	COG2945	thiolester hydrolase activity
SMD44_RS18245	COG0259	pyridoxamine-phosphate oxidase activity
SMD44_RS18260	COG1024	Enoyl-CoA hydratase
SMD44_RS18275	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SMD44_RS18330	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SMD44_RS18350	COG1090	epimerase
SMD44_RS18370	COG1136	(ABC) transporter
SMD44_RS18375	COG1136	(ABC) transporter
SMD44_RS18375	COG0577	efflux transmembrane transporter activity
SMD44_RS18505	COG0667	Aldo Keto reductase
SMD44_RS18535	COG2252	PERMEase
SMD44_RS18545	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SMD44_RS18575	COG2814	Major facilitator Superfamily
SMD44_RS18585	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SMD44_RS18590	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SMD44_RS18595	COG1278	Cold shock
SMD44_RS18615	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD44_RS18620	COG1120	ATPase activity
SMD44_RS18625	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SMD44_RS18660	COG1061	Type III restriction enzyme res subunit
SMD44_RS18670	COG3973	AAA domain
SMD44_RS18715	COG2205	protein histidine kinase activity
SMD44_RS18720	COG0745	RESPONSE REGULATOR receiver
SMD44_RS18745	COG0577	efflux transmembrane transporter activity
SMD44_RS18745	COG1136	(ABC) transporter
SMD44_RS18765	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SMD44_RS18785	COG1595	DNA-templated transcription, initiation
SMD44_RS18810	COG0463	Glycosyl transferase, family 2
SMD44_RS18905	COG2197	response regulator
SMD44_RS18925	COG4552	Acetyltransferase involved in intracellular survival and related
SMD44_RS18950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMD44_RS18965	COG3842	ATPase activity
SMD44_RS18975	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SMD44_RS18985	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SMD44_RS18990	COG0215	cysteine-tRNA ligase activity
SMD44_RS18995	COG3467	pyridoxamine 5'-phosphate
SMD44_RS19000	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SMD44_RS19005	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SMD44_RS19010	COG1329	Transcriptional regulator
SMD44_RS19030	COG5002	protein histidine kinase activity
SMD44_RS19045	COG0588	phosphoglycerate mutase activity
SMD44_RS19075	COG0438	transferase activity, transferring glycosyl groups
SMD44_RS19220	COG2186	Transcriptional regulator
SMD44_RS19240	COG1490	D-aminoacyl-tRNA deacylase activity
SMD44_RS19245	COG0354	folic acid binding
SMD44_RS19255	COG3485	protocatechuate 3,4-dioxygenase
SMD44_RS19275	COG2897	thiosulfate sulfurtransferase activity
SMD44_RS19300	COG0745	RESPONSE REGULATOR receiver
SMD44_RS19305	COG1609	Transcriptional regulator
SMD44_RS19310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMD44_RS19315	COG0745	RESPONSE REGULATOR receiver
SMD44_RS19325	COG0488	(ABC) transporter
SMD44_RS19335	COG0737	Belongs to the 5'-nucleotidase family
SMD44_RS19340	COG0456	acetyltransferase
SMD44_RS19345	COG1725	Transcriptional regulator
SMD44_RS19350	COG1131	(ABC) transporter
SMD44_RS19360	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SMD44_RS19390	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SMD44_RS19400	COG0306	phosphate transporter
SMD44_RS19410	COG1937	Protein conserved in bacteria
SMD44_RS19425	COG0277	FAD linked oxidase domain protein
SMD44_RS19430	COG0671	phosphoesterase, PA-phosphatase related
SMD44_RS19435	COG1196	nuclear chromosome segregation
SMD44_RS19435	COG0741	lytic transglycosylase activity
SMD44_RS19435	COG0739	heme binding
SMD44_RS19505	COG1131	(ABC) transporter
SMD44_RS19515	COG4585	Histidine kinase
SMD44_RS19545	COG1846	Transcriptional regulator
SMD44_RS19560	COG1252	NADH dehydrogenase
SMD44_RS19570	COG1470	cell adhesion involved in biofilm formation
SMD44_RS19570	COG0366	Alpha amylase catalytic
SMD44_RS19590	COG0579	oxidoreductase
SMD44_RS19595	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SMD44_RS19605	COG0667	Aldo Keto reductase
SMD44_RS19690	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SMD44_RS19705	COG0798	PFAM Bile acid sodium symporter
SMD44_RS19715	COG0640	Transcriptional regulator
SMD44_RS19730	COG0513	Belongs to the DEAD box helicase family
SMD44_RS19760	COG3903	Transcriptional regulator
SMD44_RS19760	COG3629	intracellular signal transduction
SMD44_RS19765	COG1846	Transcriptional regulator
SMD44_RS19770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMD44_RS19800	COG2814	Major facilitator Superfamily
SMD44_RS19805	COG0667	Aldo Keto reductase
SMD44_RS19815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMD44_RS19830	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS19835	COG2197	response regulator
SMD44_RS19860	COG3386	PFAM SMP-30 Gluconolaconase
SMD44_RS19875	COG3629	intracellular signal transduction
SMD44_RS19890	COG0785	Cytochrome C biogenesis protein
SMD44_RS19905	COG1643	Atp-dependent helicase
SMD44_RS19940	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SMD44_RS19975	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SMD44_RS19980	COG0047	phosphoribosylformylglycinamidine synthase activity
SMD44_RS19985	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SMD44_RS20020	COG2197	response regulator
SMD44_RS20030	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SMD44_RS20045	COG0151	Belongs to the GarS family
SMD44_RS20070	COG1609	Transcriptional regulator
SMD44_RS20160	COG0583	DNA-binding transcription factor activity
SMD44_RS20170	COG0488	(ABC) transporter
SMD44_RS20180	COG0433	COG0433 Predicted ATPase
SMD44_RS20195	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SMD44_RS20255	COG1191	sigma factor activity
SMD44_RS20260	COG1191	sigma factor activity
SMD44_RS20280	COG0477	Major facilitator Superfamily
SMD44_RS20290	COG3467	pyridoxamine 5'-phosphate
SMD44_RS20300	COG0477	Major facilitator Superfamily
SMD44_RS20315	COG2205	protein histidine kinase activity
SMD44_RS20320	COG0745	RESPONSE REGULATOR receiver
SMD44_RS20330	COG2329	Antibiotic biosynthesis monooxygenase
SMD44_RS20360	COG1595	DNA-templated transcription, initiation
SMD44_RS20365	COG1252	NADH dehydrogenase
SMD44_RS20395	COG0784	Response regulator, receiver
SMD44_RS20415	COG1309	transcriptional regulator
SMD44_RS20420	COG2814	Major facilitator Superfamily
SMD44_RS20430	COG1595	DNA-templated transcription, initiation
SMD44_RS20450	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS20460	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS20595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMD44_RS20610	COG0653	protein targeting
SMD44_RS20630	COG0006	proline dipeptidase activity
SMD44_RS20640	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMD44_RS20645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMD44_RS20650	COG1733	regulation of RNA biosynthetic process
SMD44_RS20655	COG0702	epimerase
SMD44_RS20660	COG1058	Belongs to the CinA family
SMD44_RS20660	COG1546	Belongs to the CinA family
SMD44_RS20670	COG1902	pentaerythritol trinitrate reductase activity
SMD44_RS20680	COG1803	Methylglyoxal synthase
SMD44_RS20705	COG1999	signal sequence binding
SMD44_RS20730	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SMD44_RS20735	COG0561	phosphatase activity
SMD44_RS20760	COG1131	(ABC) transporter
SMD44_RS20780	COG0789	Transcriptional regulator
SMD44_RS20800	COG1196	nuclear chromosome segregation
SMD44_RS20800	COG0739	heme binding
SMD44_RS20800	COG0741	lytic transglycosylase activity
SMD44_RS20815	COG1294	oxidase, subunit
SMD44_RS20825	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMD44_RS20830	COG1609	Transcriptional regulator
SMD44_RS20835	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SMD44_RS20850	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SMD44_RS20875	COG0662	Cupin 2, conserved barrel domain protein
SMD44_RS20880	COG1950	PFAM Membrane protein of
SMD44_RS20885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SMD44_RS20890	COG0626	cystathionine gamma-synthase activity
SMD44_RS20930	COG2814	Major facilitator Superfamily
SMD44_RS20940	COG0456	acetyltransferase
SMD44_RS20960	COG0305	Participates in initiation and elongation during chromosome replication
SMD44_RS20970	COG0359	binds to the 23S rRNA
SMD44_RS20975	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SMD44_RS20980	COG0629	single-stranded DNA binding
SMD44_RS20985	COG0360	Binds together with S18 to 16S ribosomal RNA
SMD44_RS21010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMD44_RS21035	COG0617	tRNA 3'-terminal CCA addition
SMD44_RS21050	COG0515	serine threonine protein kinase
SMD44_RS21050	COG2815	serine threonine protein kinase
SMD44_RS21055	COG1595	DNA-templated transcription, initiation
SMD44_RS21065	COG0492	ferredoxin-NADP+ reductase activity
SMD44_RS21070	COG3118	belongs to the thioredoxin family
SMD44_RS21085	COG1192	Involved in chromosome partitioning
SMD44_RS21090	COG0357	Ribosomal RNA small subunit methyltransferase G
SMD44_RS21100	COG0706	membrane insertase activity
SMD44_RS21105	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SMD44_RS21110	COG0594	ribonuclease P activity
SMD44_RS21115	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SMD44_RS21120	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SMD44_RS21130	COG0592	DNA-directed DNA polymerase activity
SMD44_RS21135	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SMD44_RS21140	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SMD44_RS21145	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
SMD44_RS21150	COG0187	DNA topoisomerase II activity
SMD44_RS21155	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SMD44_RS21195	COG0515	serine threonine protein kinase
SMD44_RS21220	COG1309	transcriptional regulator
SMD44_RS21230	COG2910	NAD(P)H-binding
SMD44_RS21285	COG0438	transferase activity, transferring glycosyl groups
SMD44_RS21305	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SMD44_RS21310	COG0297	glycogen (starch) synthase activity
SMD44_RS21375	COG2201	protein-glutamate methylesterase activity
SMD44_RS21405	COG0457	Tetratricopeptide repeat
SMD44_RS21405	COG0705	Rhomboid family
SMD44_RS21420	COG3764	Sortase (surface protein transpeptidase)
SMD44_RS21440	COG3764	Sortase (surface protein transpeptidase)
SMD44_RS21445	COG0515	serine threonine protein kinase
SMD44_RS21455	COG0768	penicillin binding
SMD44_RS21470	COG1716	ATPase activity
SMD44_RS21475	COG1716	ATPase activity
SMD44_RS21490	COG0137	argininosuccinate synthase activity
SMD44_RS21495	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SMD44_RS21515	COG1454	alcohol dehydrogenase
SMD44_RS21525	COG0439	Biotin carboxylase
SMD44_RS21620	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SMD44_RS21625	COG2226	methyltransferase
SMD44_RS21670	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SMD44_RS21675	COG2151	metal-sulfur cluster biosynthetic enzyme
SMD44_RS21680	COG3396	Phenylacetate-CoA oxygenase
SMD44_RS21685	COG3460	Phenylacetate-CoA oxygenase
SMD44_RS21690	COG3396	Phenylacetate-CoA oxygenase
SMD44_RS21715	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMD44_RS21720	COG1309	transcriptional regulator
SMD44_RS21725	COG1522	sequence-specific DNA binding
SMD44_RS21755	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SMD44_RS21795	COG0515	serine threonine protein kinase
SMD44_RS21800	COG0515	serine threonine protein kinase
SMD44_RS21820	COG0022	dehydrogenase e1 component
SMD44_RS21825	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMD44_RS21860	COG1362	aminopeptidase activity
SMD44_RS21865	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS21880	COG1741	Belongs to the pirin family
SMD44_RS21895	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SMD44_RS21970	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMD44_RS21995	COG0583	DNA-binding transcription factor activity
SMD44_RS22025	COG1289	transmembrane transporter activity
SMD44_RS22030	COG0477	Major facilitator Superfamily
SMD44_RS22105	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SMD44_RS22135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD44_RS22190	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SMD44_RS22275	COG0513	Belongs to the DEAD box helicase family
SMD44_RS22280	COG1278	Cold shock
SMD44_RS22295	COG0714	Associated with various cellular activities
SMD44_RS22300	COG3864	Putative metallopeptidase domain
SMD44_RS22310	COG3835	regulator
SMD44_RS22340	COG1309	transcriptional regulator
SMD44_RS22355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMD44_RS22365	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
SMD44_RS22370	COG2188	Transcriptional regulator
SMD44_RS22405	COG0717	Belongs to the dCTP deaminase family
SMD44_RS22465	COG0247	lactate metabolic process
SMD44_RS22465	COG2181	nitrate reductase activity
SMD44_RS22470	COG0443	Heat shock 70 kDa protein
SMD44_RS22475	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SMD44_RS22480	COG0484	heat shock protein binding
SMD44_RS22485	COG0789	Transcriptional regulator
SMD44_RS22555	COG0542	response to heat
SMD44_RS22585	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SMD44_RS22600	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SMD44_RS22605	COG0191	fructose-bisphosphate aldolase activity
SMD44_RS22610	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SMD44_RS22625	COG3844	kynureninase activity
SMD44_RS22640	COG2197	response regulator
SMD44_RS22650	COG3559	Exporter of polyketide antibiotics
SMD44_RS22655	COG1131	(ABC) transporter
SMD44_RS22670	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SMD44_RS22710	COG0693	protein deglycase activity
SMD44_RS22740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SMD44_RS22745	COG1802	Transcriptional regulator
SMD44_RS22750	COG0463	Glycosyl transferase, family 2
SMD44_RS22765	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SMD44_RS22770	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SMD44_RS22795	COG0745	RESPONSE REGULATOR receiver
SMD44_RS22800	COG2205	protein histidine kinase activity
SMD44_RS22805	COG0069	glutamate synthase activity
SMD44_RS22810	COG0028	Belongs to the TPP enzyme family
SMD44_RS22850	COG1595	DNA-templated transcription, initiation
SMD44_RS22885	COG0251	oxidation-reduction process
SMD44_RS22950	COG1309	transcriptional regulator
SMD44_RS23050	COG3903	Transcriptional regulator
SMD44_RS23050	COG3629	intracellular signal transduction
SMD44_RS23125	COG1408	metallophosphoesterase
SMD44_RS23150	COG0003	Pfam Anion-transporting ATPase
SMD44_RS23175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SMD44_RS23210	COG0596	Alpha beta hydrolase
SMD44_RS23220	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SMD44_RS23225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMD44_RS23295	COG1205	dead DEAH box helicase
SMD44_RS23295	COG1111	helicase
SMD44_RS23300	COG1366	Belongs to the anti-sigma-factor antagonist family
SMD44_RS23310	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SMD44_RS23320	COG2890	protein-(glutamine-N5) methyltransferase activity
SMD44_RS23335	COG1754	DNA topoisomerase type I activity
SMD44_RS23335	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SMD44_RS23340	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SMD44_RS23345	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SMD44_RS23385	COG1819	glycosyl
SMD44_RS23405	COG0596	Alpha beta hydrolase
SMD44_RS23440	COG0596	Alpha beta hydrolase
SMD44_RS23440	COG2945	thiolester hydrolase activity
SMD44_RS23445	COG0604	alcohol dehydrogenase
SMD44_RS23455	COG2197	response regulator
SMD44_RS23470	COG1335	isochorismatase
SMD44_RS23480	COG0596	Alpha beta hydrolase
SMD44_RS23485	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SMD44_RS23485	COG1672	PFAM Archaeal ATPase
SMD44_RS23505	COG0745	RESPONSE REGULATOR receiver
SMD44_RS23530	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMD44_RS23530	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMD44_RS23535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMD44_RS23535	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SMD44_RS23585	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SMD44_RS23590	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SMD44_RS23595	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SMD44_RS23600	COG0254	rRNA binding
SMD44_RS23610	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SMD44_RS23630	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS23635	COG2318	DinB family
SMD44_RS23660	COG0789	Transcriptional regulator
SMD44_RS23675	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SMD44_RS23680	COG2027	D-alanyl-D-alanine carboxypeptidase
SMD44_RS23690	COG0037	tRNA processing
SMD44_RS23705	COG0302	gtp cyclohydrolase
SMD44_RS23715	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SMD44_RS23720	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SMD44_RS23740	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SMD44_RS23740	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SMD44_RS23755	COG1174	glycine betaine transport
SMD44_RS23760	COG1174	glycine betaine transport
SMD44_RS23785	COG0649	NAD binding
SMD44_RS23815	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
SMD44_RS23825	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SMD44_RS23830	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SMD44_RS23840	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SMD44_RS23865	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SMD44_RS23900	COG0739	heme binding
SMD44_RS23920	COG0346	lactoylglutathione lyase activity
SMD44_RS23925	COG2205	protein histidine kinase activity
SMD44_RS23930	COG0745	RESPONSE REGULATOR receiver
SMD44_RS23940	COG1595	DNA-templated transcription, initiation
SMD44_RS23945	COG1194	a g-specific adenine glycosylase
SMD44_RS23950	COG4585	Histidine kinase
SMD44_RS23970	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
SMD44_RS23990	COG0248	Ppx GppA phosphatase
SMD44_RS23995	COG1082	Xylose isomerase domain protein TIM barrel
SMD44_RS24005	COG0129	dihydroxy-acid dehydratase activity
SMD44_RS24010	COG4991	sh3 domain protein
SMD44_RS24025	COG2226	methyltransferase
SMD44_RS24030	COG0842	Transport permease protein
SMD44_RS24030	COG1129	ABC transporter
SMD44_RS24055	COG0180	Tryptophanyl-tRNA synthetase
SMD44_RS24080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMD44_RS24090	COG0123	including yeast histone deacetylase and acetoin utilization protein
SMD44_RS24140	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SMD44_RS24145	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SMD44_RS24150	COG0181	hydroxymethylbilane synthase activity
SMD44_RS24160	COG0113	porphobilinogen synthase activity
SMD44_RS24165	COG3321	synthase
SMD44_RS24165	COG0604	alcohol dehydrogenase
SMD44_RS24190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMD44_RS24195	COG0018	arginyl-trna synthetase
SMD44_RS24200	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
SMD44_RS24225	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SMD44_RS24230	COG2226	methyltransferase
SMD44_RS24270	COG1690	Belongs to the RtcB family
SMD44_RS24310	COG0583	DNA-binding transcription factor activity
SMD44_RS24320	COG0768	penicillin binding
SMD44_RS24345	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SMD44_RS24350	COG0406	alpha-ribazole phosphatase activity
SMD44_RS24360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMD44_RS24370	COG1333	cytochrome c biogenesis protein
SMD44_RS24375	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SMD44_RS24405	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SMD44_RS24410	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SMD44_RS24415	COG0163	prenyltransferase activity
SMD44_RS24425	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SMD44_RS24435	COG1301	dicarboxylic acid transport
SMD44_RS24440	COG1309	transcriptional regulator
SMD44_RS24535	COG0747	negative chemotaxis
SMD44_RS24540	COG0601	transmembrane transport
SMD44_RS24545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMD44_RS24560	COG1278	Cold shock
SMD44_RS24565	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SMD44_RS24585	COG1674	ftsk spoiiie
SMD44_RS24650	COG1660	Displays ATPase and GTPase activities
SMD44_RS24655	COG2318	DinB family
SMD44_RS24660	COG5640	endopeptidase activity
SMD44_RS24720	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SMD44_RS24730	COG2226	methyltransferase
SMD44_RS24765	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SMD44_RS24935	COG1396	sequence-specific DNA binding
SMD44_RS24985	COG3723	Recombinational DNA repair protein, rece pathway
SMD44_RS24990	COG5377	YqaJ viral recombinase family
SMD44_RS25010	COG3103	Sh3 type 3 domain protein
SMD44_RS25010	COG0791	NLP P60 protein
SMD44_RS25010	COG1388	LysM domain
SMD44_RS25025	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMD44_RS25030	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMD44_RS25035	COG0649	NAD binding
SMD44_RS25045	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SMD44_RS25050	COG1034	ATP synthesis coupled electron transport
SMD44_RS25055	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SMD44_RS25060	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMD44_RS25065	COG0839	Belongs to the complex I subunit 6 family
SMD44_RS25070	COG0713	ATP synthesis coupled electron transport
SMD44_RS25075	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SMD44_RS25085	COG1007	ATP synthesis coupled electron transport
SMD44_RS25090	COG0514	ATP-dependent DNA helicase (RecQ)
SMD44_RS25125	COG0561	phosphatase activity
SMD44_RS25130	COG0142	geranyltranstransferase activity
SMD44_RS25185	COG0662	Cupin 2, conserved barrel domain protein
SMD44_RS25200	COG1733	regulation of RNA biosynthetic process
SMD44_RS25225	COG0702	epimerase
SMD44_RS25230	COG1733	regulation of RNA biosynthetic process
SMD44_RS25235	COG1013	pyruvate-flavodoxin oxidoreductase activity
SMD44_RS25240	COG0674	pyruvate-flavodoxin oxidoreductase activity
SMD44_RS25240	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SMD44_RS25260	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMD44_RS25265	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMD44_RS25270	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMD44_RS25275	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SMD44_RS25280	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMD44_RS25290	COG0713	ATP synthesis coupled electron transport
SMD44_RS25295	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SMD44_RS25305	COG1007	ATP synthesis coupled electron transport
SMD44_RS25310	COG0501	Belongs to the peptidase M48B family
SMD44_RS25315	COG3304	Inner membrane component domain
SMD44_RS25320	COG2261	transglycosylase associated protein
SMD44_RS25325	COG1666	GTP binding
SMD44_RS25340	COG0702	epimerase
SMD44_RS25360	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SMD44_RS25365	COG2030	dehydratase
SMD44_RS25380	COG0477	Major facilitator Superfamily
SMD44_RS25385	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SMD44_RS25390	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SMD44_RS25395	COG0436	Aminotransferase
SMD44_RS25410	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SMD44_RS25415	COG0250	Participates in transcription elongation, termination and antitermination
SMD44_RS25425	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SMD44_RS25430	COG0081	regulation of translation
SMD44_RS25445	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SMD44_RS25450	COG0222	ribosome binding
SMD44_RS25460	COG0085	RNA polymerase activity
SMD44_RS25465	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SMD44_RS25475	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SMD44_RS25480	COG0049	tRNA binding
SMD44_RS25485	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SMD44_RS25490	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SMD44_RS25495	COG0051	transcription antitermination factor activity, RNA binding
SMD44_RS25500	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SMD44_RS25505	COG0088	Forms part of the polypeptide exit tunnel
SMD44_RS25510	COG0089	rRNA binding
SMD44_RS25515	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SMD44_RS25520	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SMD44_RS25525	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SMD44_RS25530	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SMD44_RS25535	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SMD44_RS25540	COG0255	Belongs to the universal ribosomal protein uL29 family
SMD44_RS25545	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SMD44_RS25550	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SMD44_RS25555	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SMD44_RS25560	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SMD44_RS25565	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SMD44_RS25575	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SMD44_RS25580	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SMD44_RS25585	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SMD44_RS25590	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SMD44_RS25595	COG1841	ribosomal large subunit assembly
SMD44_RS25600	COG0200	Binds to the 23S rRNA
SMD44_RS25610	COG0563	adenylate kinase activity
SMD44_RS25620	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SMD44_RS25625	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SMD44_RS25630	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SMD44_RS25635	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SMD44_RS25640	COG0202	RNA polymerase activity
SMD44_RS25645	COG0203	ribosomal protein L17
SMD44_RS25650	COG0101	tRNA pseudouridine synthase activity
SMD44_RS25665	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SMD44_RS25670	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SMD44_RS25675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMD44_RS25685	COG1072	(Pantothenic acid kinase))
SMD44_RS25690	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMD44_RS25695	COG0736	holo-[acyl-carrier-protein] synthase activity
SMD44_RS25705	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SMD44_RS25715	COG0802	atpase or kinase
SMD44_RS25730	COG1214	PFAM Peptidase M22, glycoprotease
SMD44_RS25730	COG0456	acetyltransferase
SMD44_RS25740	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SMD44_RS25765	COG0726	polysaccharide deacetylase
SMD44_RS25775	COG0459	protein refolding
SMD44_RS25780	COG4221	oxidoreductase activity
SMD44_RS25785	COG2132	Multicopper oxidase
SMD44_RS25795	COG0583	DNA-binding transcription factor activity
SMD44_RS25810	COG1595	DNA-templated transcription, initiation
SMD44_RS25820	COG0516	GMP reductase activity
SMD44_RS25850	COG0515	serine threonine protein kinase
SMD44_RS25855	COG0515	serine threonine protein kinase
SMD44_RS25860	COG0515	serine threonine protein kinase
SMD44_RS25870	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS25900	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SMD44_RS25900	COG0519	Catalyzes the synthesis of GMP from XMP
SMD44_RS25940	COG2197	response regulator
SMD44_RS25945	COG0791	NLP P60 protein
SMD44_RS25975	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SMD44_RS25975	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SMD44_RS25995	COG0714	Associated with various cellular activities
SMD44_RS26005	COG3552	Protein containing von Willebrand factor type A (VWA) domain
SMD44_RS26010	COG0045	succinate-CoA ligase (ADP-forming) activity
SMD44_RS26040	COG0138	bifunctional purine biosynthesis protein purh
SMD44_RS26050	COG2815	serine threonine protein kinase
SMD44_RS26050	COG0515	serine threonine protein kinase
SMD44_RS26055	COG1714	RDD family
SMD44_RS26060	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SMD44_RS26070	COG4585	Histidine kinase
SMD44_RS26075	COG2197	response regulator
SMD44_RS26105	COG0039	L-malate dehydrogenase activity
SMD44_RS26135	COG0477	Major facilitator Superfamily
SMD44_RS26145	COG1476	TRANSCRIPTIONal
SMD44_RS26160	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS26170	COG0517	IMP dehydrogenase activity
SMD44_RS26170	COG4175	Glycine betaine
SMD44_RS26175	COG4176	ABC-type proline glycine betaine transport system permease component
SMD44_RS26190	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMD44_RS26195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMD44_RS26205	COG1959	2 iron, 2 sulfur cluster binding
SMD44_RS26230	COG0754	glutathionylspermidine amidase activity
SMD44_RS26270	COG2409	Drug exporters of the RND superfamily
SMD44_RS26345	COG1595	DNA-templated transcription, initiation
SMD44_RS26355	COG2318	DinB family
SMD44_RS26385	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMD44_RS26390	COG2130	NADP-dependent
SMD44_RS26400	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMD44_RS26405	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SMD44_RS26420	COG1595	DNA-templated transcription, initiation
SMD44_RS26450	COG0671	phosphoesterase, PA-phosphatase related
SMD44_RS26465	COG1295	ribonuclease BN
SMD44_RS26470	COG1686	Belongs to the peptidase S11 family
SMD44_RS26480	COG1408	metallophosphoesterase
SMD44_RS26485	COG2205	protein histidine kinase activity
SMD44_RS26490	COG0745	RESPONSE REGULATOR receiver
SMD44_RS26505	COG1595	DNA-templated transcription, initiation
SMD44_RS26525	COG1846	Transcriptional regulator
SMD44_RS26550	COG1140	nitrate reductase beta subunit
SMD44_RS26575	COG1053	succinate dehydrogenase
SMD44_RS26585	COG2009	succinate dehydrogenase
SMD44_RS26600	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SMD44_RS26630	COG1595	DNA-templated transcription, initiation
SMD44_RS26670	COG1216	Glycosyl transferase, family 2
SMD44_RS26685	COG2089	acid synthase
SMD44_RS26760	COG1473	amidohydrolase
SMD44_RS26760	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SMD44_RS26765	COG1744	ABC transporter substrate-binding protein PnrA-like
SMD44_RS26770	COG1744	ABC transporter substrate-binding protein PnrA-like
SMD44_RS26775	COG3845	ABC transporter
SMD44_RS26785	COG1079	Belongs to the binding-protein-dependent transport system permease family
SMD44_RS26800	COG0583	DNA-binding transcription factor activity
SMD44_RS26805	COG2814	Major facilitator Superfamily
SMD44_RS26825	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SMD44_RS26855	COG0745	RESPONSE REGULATOR receiver
SMD44_RS26860	COG1595	DNA-templated transcription, initiation
SMD44_RS26875	COG2197	response regulator
SMD44_RS26890	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS26895	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS26900	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SMD44_RS26955	COG4770	biotin carboxylase activity
SMD44_RS26965	COG0424	maF-like protein
SMD44_RS26985	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SMD44_RS26995	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SMD44_RS27000	COG1024	Enoyl-CoA hydratase
SMD44_RS27015	COG2986	histidine ammonia-lyase
SMD44_RS27050	COG1733	regulation of RNA biosynthetic process
SMD44_RS27070	COG1064	alcohol dehydrogenase
SMD44_RS27080	COG2267	carboxylic ester hydrolase activity
SMD44_RS27085	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMD44_RS27105	COG1595	DNA-templated transcription, initiation
SMD44_RS27110	COG2255	four-way junction helicase activity
SMD44_RS27115	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SMD44_RS27145	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SMD44_RS27155	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SMD44_RS27185	COG1331	Highly conserved protein containing a thioredoxin domain
SMD44_RS27200	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
SMD44_RS27210	COG0436	Aminotransferase
SMD44_RS27225	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SMD44_RS27240	COG1414	Transcriptional regulator
SMD44_RS27250	COG2610	gluconate transmembrane transporter activity
SMD44_RS27345	COG2894	cell division
SMD44_RS27390	COG2885	chlorophyll binding
SMD44_RS27410	COG1733	regulation of RNA biosynthetic process
SMD44_RS27415	COG0667	Aldo Keto reductase
SMD44_RS27420	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SMD44_RS27425	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SMD44_RS27440	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMD44_RS27445	COG0450	alkyl hydroperoxide reductase
SMD44_RS27460	COG1136	(ABC) transporter
SMD44_RS27470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMD44_RS27495	COG0114	fumarate hydratase activity
SMD44_RS27530	COG0778	Nitroreductase
SMD44_RS27535	COG1722	exodeoxyribonuclease VII activity
SMD44_RS27540	COG1570	exodeoxyribonuclease VII activity
SMD44_RS27550	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SMD44_RS27565	COG0012	GTP binding
SMD44_RS27570	COG2161	toxin-antitoxin pair type II binding
SMD44_RS27575	COG4115	mRNA cleavage
SMD44_RS27600	COG1846	Transcriptional regulator
SMD44_RS27655	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SMD44_RS27680	COG1217	gtp-binding protein TYPA
SMD44_RS27690	COG0601	transmembrane transport
SMD44_RS27695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMD44_RS27700	COG0444	Belongs to the ABC transporter superfamily
SMD44_RS27705	COG4608	Belongs to the ABC transporter superfamily
SMD44_RS27720	COG0601	transmembrane transport
SMD44_RS27725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMD44_RS27730	COG0444	Belongs to the ABC transporter superfamily
SMD44_RS27735	COG4608	Belongs to the ABC transporter superfamily
SMD44_RS27750	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SMD44_RS27765	COG1131	(ABC) transporter
SMD44_RS27770	COG0842	Transport permease protein
SMD44_RS27775	COG4585	Histidine kinase
SMD44_RS27780	COG2197	response regulator
SMD44_RS27820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMD44_RS27825	COG1611	Belongs to the LOG family
SMD44_RS27830	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SMD44_RS27840	COG2818	Glycosylase
SMD44_RS27845	COG1024	Enoyl-CoA hydratase
SMD44_RS27860	COG1595	DNA-templated transcription, initiation
SMD44_RS27870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMD44_RS27875	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SMD44_RS27910	COG0598	Magnesium transport protein CorA
SMD44_RS27935	COG2095	MarC family integral membrane protein
SMD44_RS27945	COG1432	Conserved Protein
SMD44_RS27950	COG0596	Alpha beta hydrolase
SMD44_RS27955	COG0513	Belongs to the DEAD box helicase family
SMD44_RS27995	COG0747	negative chemotaxis
SMD44_RS28005	COG0601	transmembrane transport
SMD44_RS28075	COG0210	DNA helicase
SMD44_RS28080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMD44_RS28125	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SMD44_RS28180	COG3480	Lon protease (S16) C-terminal proteolytic domain
SMD44_RS28190	COG1615	UPF0182 protein
SMD44_RS28215	COG0753	catalase activity
SMD44_RS28225	COG0483	inositol monophosphate 1-phosphatase activity
SMD44_RS28235	COG2076	Multidrug Resistance protein
SMD44_RS28240	COG1162	GTPase activity
SMD44_RS28245	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SMD44_RS28255	COG2135	peptidase activity
SMD44_RS28265	COG1595	DNA-templated transcription, initiation
SMD44_RS28270	COG5662	AntiSigma factor
SMD44_RS28275	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SMD44_RS28275	COG2199	diguanylate cyclase activity
SMD44_RS28290	COG0242	peptide deformylase activity
SMD44_RS28300	COG2124	cytochrome p450
SMD44_RS28315	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMD44_RS28355	COG2182	Extracellular solute-binding protein
SMD44_RS28360	COG1175	transmembrane transport
SMD44_RS28365	COG0395	ABC-type sugar transport system, permease component
SMD44_RS28370	COG1472	Belongs to the glycosyl hydrolase 3 family
SMD44_RS28375	COG0363	glucosamine-6-phosphate deaminase activity
SMD44_RS28380	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMD44_RS28385	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS28390	COG1309	transcriptional regulator
SMD44_RS28405	COG1597	lipid kinase activity
SMD44_RS28420	COG2172	sigma factor antagonist activity
SMD44_RS28450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMD44_RS28455	COG0142	geranyltranstransferase activity
SMD44_RS28485	COG1595	DNA-templated transcription, initiation
SMD44_RS28510	COG4106	trans-aconitate 2-methyltransferase activity
SMD44_RS28515	COG1126	abc transporter atp-binding protein
SMD44_RS28540	COG0604	alcohol dehydrogenase
SMD44_RS28590	COG0567	Dehydrogenase, E1 component
SMD44_RS28590	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMD44_RS28595	COG2205	protein histidine kinase activity
SMD44_RS28600	COG0745	RESPONSE REGULATOR receiver
SMD44_RS28630	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SMD44_RS28705	COG2318	DinB family
SMD44_RS28710	COG0768	penicillin binding
SMD44_RS28715	COG0772	Belongs to the SEDS family
SMD44_RS28725	COG2205	protein histidine kinase activity
SMD44_RS28755	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SMD44_RS28760	COG2267	carboxylic ester hydrolase activity
SMD44_RS28780	COG0745	RESPONSE REGULATOR receiver
SMD44_RS28790	COG0018	arginyl-trna synthetase
SMD44_RS28795	COG0019	diaminopimelate decarboxylase activity
SMD44_RS28800	COG0460	homoserine dehydrogenase
SMD44_RS28805	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SMD44_RS28810	COG0083	homoserine kinase activity
SMD44_RS28825	COG0254	rRNA binding
SMD44_RS28830	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SMD44_RS28835	COG2890	protein-(glutamine-N5) methyltransferase activity
SMD44_RS28845	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SMD44_RS28850	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SMD44_RS28870	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SMD44_RS28875	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SMD44_RS28880	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SMD44_RS28885	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SMD44_RS28890	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SMD44_RS28895	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SMD44_RS28900	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SMD44_RS28915	COG2197	response regulator
SMD44_RS28920	COG4585	Histidine kinase
SMD44_RS28950	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMD44_RS28965	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
SMD44_RS29030	COG0183	Belongs to the thiolase family
SMD44_RS29045	COG0745	RESPONSE REGULATOR receiver
SMD44_RS29050	COG2205	protein histidine kinase activity
SMD44_RS29140	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SMD44_RS29140	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SMD44_RS29155	COG1476	TRANSCRIPTIONal
SMD44_RS29180	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SMD44_RS29185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMD44_RS29225	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SMD44_RS29230	COG0280	phosphate acetyltransferase
SMD44_RS29230	COG0857	belongs to the CobB CobQ family
SMD44_RS29235	COG0205	6-phosphofructokinase activity
SMD44_RS29245	COG0395	ABC-type sugar transport system, permease component
SMD44_RS29260	COG4565	transcriptional regulatory protein
SMD44_RS29265	COG3290	protein histidine kinase activity
SMD44_RS29270	COG1301	dicarboxylic acid transport
SMD44_RS29315	COG0477	Major facilitator Superfamily
SMD44_RS29340	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMD44_RS29345	COG0515	serine threonine protein kinase
SMD44_RS29375	COG2226	methyltransferase
SMD44_RS29380	COG2409	Drug exporters of the RND superfamily
SMD44_RS29390	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SMD44_RS29395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMD44_RS29430	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SMD44_RS29435	COG3281	Trehalose synthase
SMD44_RS29465	COG0515	serine threonine protein kinase
SMD44_RS29465	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMD44_RS29470	COG0515	serine threonine protein kinase
SMD44_RS29470	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMD44_RS29475	COG0515	serine threonine protein kinase
SMD44_RS29475	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMD44_RS29480	COG0058	SHG alpha-glucan phosphorylase activity
SMD44_RS29510	COG1132	(ABC) transporter
SMD44_RS29515	COG1132	(ABC) transporter
SMD44_RS29520	COG1131	(ABC) transporter
SMD44_RS29535	COG4585	Histidine kinase
SMD44_RS29540	COG2197	response regulator
SMD44_RS29560	COG1376	ErfK ybiS ycfS ynhG family protein
SMD44_RS29605	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMD44_RS29615	COG2367	Beta-lactamase
SMD44_RS29620	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SMD44_RS29630	COG0604	alcohol dehydrogenase
SMD44_RS29650	COG1760	l-serine dehydratase
SMD44_RS29655	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SMD44_RS29660	COG0509	glycine decarboxylation via glycine cleavage system
SMD44_RS29665	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SMD44_RS29690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMD44_RS29695	COG0747	negative chemotaxis
SMD44_RS29705	COG0444	Belongs to the ABC transporter superfamily
SMD44_RS29715	COG2860	membrane
SMD44_RS29725	COG2855	membrane
SMD44_RS29735	COG0583	DNA-binding transcription factor activity
SMD44_RS29740	COG2378	regulation of single-species biofilm formation
SMD44_RS29745	COG0596	Alpha beta hydrolase
SMD44_RS29775	COG0482	sulfurtransferase activity
SMD44_RS29800	COG4221	oxidoreductase activity
SMD44_RS29810	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SMD44_RS29825	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SMD44_RS29830	COG0154	amidase activity
SMD44_RS29840	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SMD44_RS29860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMD44_RS29875	COG2197	response regulator
SMD44_RS29890	COG0667	Aldo Keto reductase
SMD44_RS29915	COG0440	acetolactate synthase activity
SMD44_RS29920	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SMD44_RS29925	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMD44_RS29930	COG0477	Major facilitator Superfamily
SMD44_RS29955	COG0506	proline dehydrogenase activity
SMD44_RS29960	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS29970	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
SMD44_RS29970	COG0778	Nitroreductase
SMD44_RS29980	COG0575	Belongs to the CDS family
SMD44_RS29995	COG2130	NADP-dependent
SMD44_RS30000	COG0583	DNA-binding transcription factor activity
SMD44_RS30020	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SMD44_RS30025	COG1309	transcriptional regulator
SMD44_RS30040	COG0832	Belongs to the urease beta subunit family
SMD44_RS30040	COG0831	urea catabolic process
SMD44_RS30045	COG0804	urea catabolic process
SMD44_RS30050	COG2957	Belongs to the agmatine deiminase family
SMD44_RS30090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMD44_RS30140	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SMD44_RS30165	COG2018	Roadblock/LC7 domain
SMD44_RS30185	COG2018	Roadblock/LC7 domain
SMD44_RS30190	COG5002	protein histidine kinase activity
SMD44_RS30200	COG0179	Fumarylacetoacetate (FAA) hydrolase
SMD44_RS30205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMD44_RS30240	COG1414	Transcriptional regulator
SMD44_RS30245	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SMD44_RS30250	COG0066	3-isopropylmalate dehydratase activity
SMD44_RS30260	COG0776	regulation of translation
SMD44_RS30270	COG1920	GTP binding
SMD44_RS30280	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SMD44_RS30285	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMD44_RS30305	COG0351	phosphomethylpyrimidine kinase
SMD44_RS30320	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SMD44_RS30335	COG0742	ribosomal rna small subunit methyltransferase
SMD44_RS30340	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SMD44_RS30355	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SMD44_RS30360	COG0571	ribonuclease III activity
SMD44_RS30365	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SMD44_RS30370	COG1733	regulation of RNA biosynthetic process
SMD44_RS30380	COG2340	Cysteine-rich secretory protein family
SMD44_RS30385	COG1254	Belongs to the acylphosphatase family
SMD44_RS30395	COG1196	nuclear chromosome segregation
SMD44_RS30400	COG0477	Major facilitator Superfamily
SMD44_RS30410	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
SMD44_RS30450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMD44_RS30465	COG0442	prolyl-tRNA aminoacylation
SMD44_RS30475	COG0228	four-way junction DNA binding
SMD44_RS30480	COG1837	Belongs to the UPF0109 family
SMD44_RS30485	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SMD44_RS30490	COG0336	Belongs to the RNA methyltransferase TrmD family
SMD44_RS30495	COG0335	large ribosomal subunit rRNA binding
SMD44_RS30505	COG0681	Belongs to the peptidase S26 family
SMD44_RS30510	COG0681	Belongs to the peptidase S26 family
SMD44_RS30515	COG0681	Belongs to the peptidase S26 family
SMD44_RS30530	COG0792	nuclease activity
SMD44_RS30550	COG1191	sigma factor activity
SMD44_RS30565	COG0052	Belongs to the universal ribosomal protein uS2 family
SMD44_RS30570	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SMD44_RS30575	COG0528	UMP kinase activity
SMD44_RS30580	COG0233	cytoplasmic translational termination
SMD44_RS30585	COG0575	Belongs to the CDS family
SMD44_RS30590	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SMD44_RS30605	COG3842	ATPase activity
SMD44_RS30630	COG4181	ATPase activity
SMD44_RS30635	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SMD44_RS30645	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS30665	COG1309	transcriptional regulator
SMD44_RS30670	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS30700	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SMD44_RS30710	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS30720	COG3842	ATPase activity
SMD44_RS30725	COG1176	ABC-type spermidine putrescine transport system, permease component I
SMD44_RS30730	COG1177	transmembrane transport
SMD44_RS30735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMD44_RS30770	COG2508	Transcriptional regulator
SMD44_RS30775	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS30790	COG0750	zinc metalloprotease
SMD44_RS30795	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SMD44_RS30800	COG1609	Transcriptional regulator
SMD44_RS30825	COG0442	prolyl-tRNA aminoacylation
SMD44_RS30850	COG0779	Required for maturation of 30S ribosomal subunits
SMD44_RS30875	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SMD44_RS30880	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SMD44_RS30915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMD44_RS30920	COG0601	transmembrane transport
SMD44_RS30925	COG0747	negative chemotaxis
SMD44_RS30955	COG1404	Belongs to the peptidase S8 family
SMD44_RS31020	COG1674	ftsk spoiiie
SMD44_RS31030	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SMD44_RS31035	COG1185	polyribonucleotide nucleotidyltransferase activity
SMD44_RS31040	COG0612	Peptidase, M16
SMD44_RS31045	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SMD44_RS31070	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SMD44_RS31105	COG2770	Histidine kinase
SMD44_RS31105	COG2208	phosphoserine phosphatase activity
SMD44_RS31115	COG4999	Histidine kinase
SMD44_RS31115	COG3850	Histidine kinase
SMD44_RS31115	COG3437	response regulator, receiver
SMD44_RS31115	COG2205	protein histidine kinase activity
SMD44_RS31125	COG1674	ftsk spoiiie
SMD44_RS31135	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SMD44_RS31145	COG1546	Belongs to the CinA family
SMD44_RS31145	COG1058	Belongs to the CinA family
SMD44_RS31150	COG1396	sequence-specific DNA binding
SMD44_RS31155	COG0783	Belongs to the Dps family
SMD44_RS31165	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS31170	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SMD44_RS31205	COG0628	permease
SMD44_RS31215	COG0640	Transcriptional regulator
SMD44_RS31220	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SMD44_RS31260	COG0765	amino acid transport
SMD44_RS31265	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
SMD44_RS31270	COG1126	abc transporter atp-binding protein
SMD44_RS31280	COG2205	protein histidine kinase activity
SMD44_RS31320	COG1595	DNA-templated transcription, initiation
SMD44_RS31340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SMD44_RS31360	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SMD44_RS31370	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SMD44_RS31375	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SMD44_RS31385	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SMD44_RS31425	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SMD44_RS31430	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SMD44_RS31435	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMD44_RS31460	COG0488	(ABC) transporter
SMD44_RS31465	COG0588	phosphoglycerate mutase activity
SMD44_RS31485	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SMD44_RS31520	COG1116	anion transmembrane transporter activity
SMD44_RS31525	COG1802	Transcriptional regulator
SMD44_RS31530	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SMD44_RS31545	COG0187	DNA topoisomerase II activity
SMD44_RS31555	COG4585	Histidine kinase
SMD44_RS31560	COG2197	response regulator
SMD44_RS31570	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SMD44_RS31575	COG4565	transcriptional regulatory protein
SMD44_RS31580	COG3290	protein histidine kinase activity
SMD44_RS31595	COG0372	Belongs to the citrate synthase family
SMD44_RS31615	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SMD44_RS31620	COG0612	Peptidase, M16
SMD44_RS31635	COG1802	Transcriptional regulator
SMD44_RS31640	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMD44_RS31650	COG0045	succinate-CoA ligase (ADP-forming) activity
SMD44_RS31650	COG1042	CoA-binding domain protein
SMD44_RS31650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMD44_RS31665	COG1435	thymidine kinase activity
SMD44_RS31710	COG0745	RESPONSE REGULATOR receiver
SMD44_RS31715	COG2205	protein histidine kinase activity
SMD44_RS31755	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SMD44_RS31760	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SMD44_RS31765	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SMD44_RS31810	COG2124	cytochrome p450
SMD44_RS31845	COG0475	glutathione-regulated potassium exporter activity
SMD44_RS31870	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS31875	COG0436	Aminotransferase
SMD44_RS31880	COG3483	tryptophan 2,3-dioxygenase activity
SMD44_RS31915	COG0569	domain protein
SMD44_RS31935	COG0531	amino acid
SMD44_RS31940	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SMD44_RS31985	COG2080	2 iron, 2 sulfur cluster binding
SMD44_RS31985	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMD44_RS31990	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SMD44_RS32055	COG1132	(ABC) transporter
SMD44_RS32075	COG1799	cell septum assembly
SMD44_RS32110	COG2197	response regulator
SMD44_RS32115	COG4585	Histidine kinase
SMD44_RS32125	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SMD44_RS32135	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SMD44_RS32140	COG2235	arginine
SMD44_RS32145	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SMD44_RS32155	COG1024	Enoyl-CoA hydratase
SMD44_RS32200	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SMD44_RS32220	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SMD44_RS32260	COG3537	Alpha-1,2-mannosidase
SMD44_RS32280	COG1175	transmembrane transport
SMD44_RS32285	COG0395	ABC-type sugar transport system, permease component
SMD44_RS32290	COG1940	carbohydrate kinase activity
SMD44_RS32295	COG4213	ABC transporter substrate-binding protein
SMD44_RS32305	COG4214	carbohydrate transport
SMD44_RS32310	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SMD44_RS32315	COG0531	amino acid
SMD44_RS32325	COG2843	Capsule synthesis protein
SMD44_RS32360	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMD44_RS32360	COG1024	Enoyl-CoA hydratase
SMD44_RS32390	COG0446	pyridine nucleotide-disulphide oxidoreductase
SMD44_RS32400	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SMD44_RS32405	COG3253	May function as heme-dependent peroxidase
SMD44_RS32430	COG3220	belongs to the UPF0276 family
SMD44_RS32480	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
SMD44_RS32510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SMD44_RS32515	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMD44_RS32530	COG2124	cytochrome p450
SMD44_RS32575	COG0443	Heat shock 70 kDa protein
SMD44_RS32580	COG0443	Heat shock 70 kDa protein
SMD44_RS32585	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SMD44_RS32625	COG0504	CTP synthase activity
SMD44_RS32630	COG0583	DNA-binding transcription factor activity
SMD44_RS32645	COG1280	lysine exporter protein (LysE YggA)
SMD44_RS32655	COG0667	Aldo Keto reductase
SMD44_RS32670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMD44_RS32670	COG0723	plastoquinol--plastocyanin reductase activity
SMD44_RS32760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMD44_RS32765	COG2364	Membrane
SMD44_RS32790	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SMD44_RS32805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SMD44_RS32810	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
SMD44_RS32830	COG0529	Catalyzes the synthesis of activated sulfate
SMD44_RS32835	COG0175	sulfate reduction
SMD44_RS32860	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS32890	COG1051	belongs to the nudix hydrolase family
SMD44_RS32920	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SMD44_RS32930	COG1162	GTPase activity
SMD44_RS32940	COG3250	beta-galactosidase activity
SMD44_RS32940	COG5297	Belongs to the glycosyl hydrolase family 6
SMD44_RS32980	COG0028	Belongs to the TPP enzyme family
SMD44_RS33010	COG1802	Transcriptional regulator
SMD44_RS33035	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMD44_RS33040	COG2252	PERMEase
SMD44_RS33060	COG2124	cytochrome p450
SMD44_RS33155	COG0464	growth
SMD44_RS33225	COG0596	Alpha beta hydrolase
SMD44_RS33230	COG2197	response regulator
SMD44_RS33235	COG1090	epimerase
SMD44_RS33240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SMD44_RS33250	COG2132	Multicopper oxidase
SMD44_RS33260	COG2197	response regulator
SMD44_RS33265	COG0598	Magnesium transport protein CorA
SMD44_RS33280	COG2197	response regulator
SMD44_RS33285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMD44_RS33290	COG0318	PFAM AMP-dependent synthetase and ligase
SMD44_RS33300	COG3960	tartronate-semialdehyde synthase activity
SMD44_RS33305	COG0477	Major facilitator Superfamily
SMD44_RS33325	COG0753	catalase activity
SMD44_RS33330	COG2084	Dehydrogenase
SMD44_RS33335	COG3622	Belongs to the hyi family
SMD44_RS33355	COG2351	hydroxyisourate hydrolase activity
SMD44_RS33365	COG2233	PERMEase
SMD44_RS33375	COG2233	PERMEase
SMD44_RS33405	COG2133	pyrroloquinoline quinone binding
SMD44_RS33405	COG5183	chlorophyll binding
SMD44_RS33455	COG0667	Aldo Keto reductase
SMD44_RS33470	COG0588	phosphoglycerate mutase activity
SMD44_RS33490	COG0436	Aminotransferase
SMD44_RS33520	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SMD44_RS33535	COG1414	Transcriptional regulator
SMD44_RS33540	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SMD44_RS33545	COG4266	Belongs to the allantoicase family
SMD44_RS33550	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS33585	COG2197	response regulator
SMD44_RS33600	COG0673	inositol 2-dehydrogenase activity
SMD44_RS33630	COG1940	carbohydrate kinase activity
SMD44_RS33675	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SMD44_RS33680	COG2801	Transposase and inactivated derivatives
SMD44_RS33790	COG1302	Protein conserved in bacteria
SMD44_RS33810	COG4585	Histidine kinase
SMD44_RS33815	COG2197	response regulator
SMD44_RS33860	COG1132	(ABC) transporter
SMD44_RS33890	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SMD44_RS33915	COG1126	abc transporter atp-binding protein
SMD44_RS33920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMD44_RS33925	COG0765	amino acid transport
SMD44_RS33930	COG0765	amino acid transport
SMD44_RS33970	COG0477	Major facilitator Superfamily
SMD44_RS33995	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMD44_RS34000	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SMD44_RS34010	COG3291	Pkd domain containing protein
SMD44_RS34015	COG1802	Transcriptional regulator
SMD44_RS34025	COG1953	Uracil, thiamine, allantoin
SMD44_RS34075	COG2124	cytochrome p450
SMD44_RS34120	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMD44_RS34160	COG1929	Belongs to the glycerate kinase type-1 family
SMD44_RS34170	COG0688	phosphatidylethanolamine metabolic process
SMD44_RS34175	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS34185	COG2301	Belongs to the HpcH HpaI aldolase family
SMD44_RS34190	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SMD44_RS34190	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SMD44_RS34195	COG0604	alcohol dehydrogenase
SMD44_RS34205	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMD44_RS34255	COG2226	methyltransferase
SMD44_RS34280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMD44_RS34300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMD44_RS34335	COG1252	NADH dehydrogenase
SMD44_RS34390	COG2226	methyltransferase
SMD44_RS34395	COG1597	lipid kinase activity
SMD44_RS34400	COG0488	(ABC) transporter
SMD44_RS34485	COG1404	Belongs to the peptidase S8 family
SMD44_RS34510	COG2154	pterin-4-alpha-carbinolamine dehydratase
SMD44_RS34555	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SMD44_RS34560	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
SMD44_RS34655	COG3383	formate dehydrogenase (NAD+) activity
SMD44_RS34660	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SMD44_RS34665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMD44_RS34695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMD44_RS34705	COG1940	carbohydrate kinase activity
SMD44_RS34710	COG1129	ABC transporter
SMD44_RS34715	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMD44_RS34725	COG0673	inositol 2-dehydrogenase activity
SMD44_RS34790	COG2223	nitrite transmembrane transporter activity
SMD44_RS34810	COG0045	succinate-CoA ligase (ADP-forming) activity
SMD44_RS34820	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS34915	COG1472	Belongs to the glycosyl hydrolase 3 family
SMD44_RS34920	COG1063	alcohol dehydrogenase
SMD44_RS34925	COG0673	inositol 2-dehydrogenase activity
SMD44_RS34970	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SMD44_RS34980	COG4948	Mandelate Racemase Muconate Lactonizing
SMD44_RS34985	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SMD44_RS35025	COG3246	L-lysine catabolic process to acetate
SMD44_RS35030	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMD44_RS35040	COG1486	melibiose metabolic process
SMD44_RS35060	COG3511	phospholipase C
SMD44_RS35095	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SMD44_RS35100	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS35120	COG1309	transcriptional regulator
SMD44_RS35125	COG0183	Belongs to the thiolase family
SMD44_RS35130	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SMD44_RS35130	COG1672	PFAM Archaeal ATPase
SMD44_RS35160	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS35175	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SMD44_RS35180	COG3485	protocatechuate 3,4-dioxygenase
SMD44_RS35185	COG3485	protocatechuate 3,4-dioxygenase
SMD44_RS35200	COG1846	Transcriptional regulator
SMD44_RS35215	COG1793	dna ligase
SMD44_RS35315	COG1515	deoxyribonuclease V activity
SMD44_RS35320	COG3268	Saccharopine dehydrogenase
SMD44_RS35330	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SMD44_RS35335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD44_RS35340	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS35345	COG0183	Belongs to the thiolase family
SMD44_RS35350	COG1024	Enoyl-CoA hydratase
SMD44_RS35350	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMD44_RS35355	COG0789	Transcriptional regulator
SMD44_RS35365	COG1113	amino acid transport
SMD44_RS35380	COG2936	dipeptidyl-peptidase activity
SMD44_RS35390	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SMD44_RS35410	COG0488	(ABC) transporter
SMD44_RS35500	COG1134	teichoic acid transport
SMD44_RS35500	COG1388	LysM domain
SMD44_RS35505	COG1562	ergosterol biosynthetic process
SMD44_RS35515	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SMD44_RS35525	COG1657	PFAM Prenyltransferase squalene oxidase
SMD44_RS35540	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SMD44_RS35545	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SMD44_RS35575	COG2755	lipolytic protein G-D-S-L family
SMD44_RS35595	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SMD44_RS35615	COG0494	nUDIX hydrolase
SMD44_RS35970	COG0583	DNA-binding transcription factor activity
SMD44_RS35975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SMD44_RS35985	COG1116	anion transmembrane transporter activity
SMD44_RS36010	COG2267	carboxylic ester hydrolase activity
SMD44_RS36025	COG3958	Transketolase
SMD44_RS36030	COG3959	Transketolase, thiamine diphosphate binding domain
SMD44_RS36065	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SMD44_RS36080	COG3903	Transcriptional regulator
SMD44_RS36080	COG3629	intracellular signal transduction
SMD44_RS36125	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SMD44_RS36130	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SMD44_RS36135	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMD44_RS36155	COG2409	Drug exporters of the RND superfamily
SMD44_RS36170	COG0248	Ppx GppA phosphatase
SMD44_RS36185	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SMD44_RS36200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD44_RS36205	COG0156	8-amino-7-oxononanoate synthase activity
SMD44_RS36210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMD44_RS36215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMD44_RS36220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMD44_RS36230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMD44_RS36260	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS36265	COG3321	synthase
SMD44_RS36265	COG3321	synthase
SMD44_RS36270	COG3629	intracellular signal transduction
SMD44_RS36290	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SMD44_RS36295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMD44_RS36295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMD44_RS36300	COG0668	transmembrane transport
SMD44_RS36335	COG1175	transmembrane transport
SMD44_RS36340	COG0395	ABC-type sugar transport system, permease component
SMD44_RS36355	COG2319	Wd-40 repeat
SMD44_RS36355	COG4249	Peptidase C14 caspase catalytic subunit p20
SMD44_RS36360	COG2340	Cysteine-rich secretory protein family
SMD44_RS36430	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SMD44_RS36455	COG0604	alcohol dehydrogenase
SMD44_RS36455	COG3321	synthase
SMD44_RS36460	COG0512	Glutamine amidotransferase of anthranilate synthase
SMD44_RS36460	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SMD44_RS36470	COG2124	cytochrome p450
SMD44_RS36505	COG0604	alcohol dehydrogenase
SMD44_RS36505	COG3321	synthase
SMD44_RS36535	COG0604	alcohol dehydrogenase
SMD44_RS36535	COG3321	synthase
SMD44_RS36615	COG1595	DNA-templated transcription, initiation
SMD44_RS36645	COG0154	amidase activity
SMD44_RS36655	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS36685	COG2130	NADP-dependent
SMD44_RS36705	COG1132	(ABC) transporter
SMD44_RS36720	COG2814	Major facilitator Superfamily
SMD44_RS36740	COG0463	Glycosyl transferase, family 2
SMD44_RS36770	COG1131	(ABC) transporter
SMD44_RS36785	COG3321	synthase
SMD44_RS36785	COG0604	alcohol dehydrogenase
SMD44_RS36785	COG3321	synthase
SMD44_RS36785	COG0604	alcohol dehydrogenase
SMD44_RS36850	COG3321	synthase
SMD44_RS36850	COG0604	alcohol dehydrogenase
SMD44_RS36875	COG3321	synthase
SMD44_RS36875	COG0604	alcohol dehydrogenase
SMD44_RS36905	COG0318	PFAM AMP-dependent synthetase and ligase
SMD44_RS36915	COG2124	cytochrome p450
SMD44_RS36935	COG4585	Histidine kinase
SMD44_RS36945	COG4585	Histidine kinase
SMD44_RS36960	COG2409	Drug exporters of the RND superfamily
SMD44_RS37005	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SMD44_RS37030	COG0297	glycogen (starch) synthase activity
SMD44_RS37035	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SMD44_RS37040	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMD44_RS37045	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMD44_RS37050	COG1129	ABC transporter
SMD44_RS37055	COG1879	ABC-type sugar transport system periplasmic component
SMD44_RS37060	COG1609	Transcriptional regulator
SMD44_RS37070	COG3537	Alpha-1,2-mannosidase
SMD44_RS37125	COG1609	Transcriptional regulator
SMD44_RS37130	COG1653	transport
SMD44_RS37135	COG1175	transmembrane transport
SMD44_RS37140	COG0395	ABC-type sugar transport system, permease component
SMD44_RS37155	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SMD44_RS37180	COG1129	ABC transporter
SMD44_RS37195	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS37215	COG3152	Membrane
SMD44_RS37225	COG2197	response regulator
SMD44_RS37230	COG4585	Histidine kinase
SMD44_RS37235	COG1131	(ABC) transporter
SMD44_RS37265	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SMD44_RS37295	COG0531	amino acid
SMD44_RS37305	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SMD44_RS37305	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SMD44_RS37310	COG0726	polysaccharide deacetylase
SMD44_RS37370	COG1053	succinate dehydrogenase
SMD44_RS37390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD44_RS37400	COG1733	regulation of RNA biosynthetic process
SMD44_RS37405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMD44_RS37430	COG2755	lipolytic protein G-D-S-L family
SMD44_RS37430	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SMD44_RS37435	COG0745	RESPONSE REGULATOR receiver
SMD44_RS37465	COG2182	Extracellular solute-binding protein
SMD44_RS37470	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SMD44_RS37475	COG0121	glutamine amidotransferase
SMD44_RS37480	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SMD44_RS37505	COG1609	Transcriptional regulator
SMD44_RS37510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMD44_RS37525	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SMD44_RS37600	COG0842	Transport permease protein
SMD44_RS37600	COG1129	ABC transporter
SMD44_RS37700	COG1733	regulation of RNA biosynthetic process
SMD44_RS37765	COG2084	Dehydrogenase
SMD44_RS37770	COG1733	regulation of RNA biosynthetic process
SMD44_RS37800	COG0546	phosphoglycolate phosphatase activity
SMD44_RS37805	COG2264	protein methyltransferase activity
SMD44_RS37890	COG0517	IMP dehydrogenase activity
SMD44_RS37900	COG0789	Transcriptional regulator
SMD44_RS37905	COG2318	DinB family
SMD44_RS37910	COG0318	PFAM AMP-dependent synthetase and ligase
SMD44_RS37960	COG1100	Small GTP-binding protein
SMD44_RS37985	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SMD44_RS38000	COG4245	von Willebrand factor, type A
SMD44_RS38035	COG0596	Alpha beta hydrolase
SMD44_RS38070	COG0745	RESPONSE REGULATOR receiver
SMD44_RS38100	COG1309	transcriptional regulator
SMD44_RS38135	COG3409	Peptidoglycan-binding domain 1 protein
SMD44_RS38185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMD44_RS38200	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMD44_RS38220	COG0366	Alpha amylase catalytic
SMD44_RS38225	COG0395	ABC-type sugar transport system, permease component
SMD44_RS38230	COG1175	transmembrane transport
SMD44_RS38245	COG1132	(ABC) transporter
SMD44_RS38275	COG1174	glycine betaine transport
SMD44_RS38295	COG1139	Iron-sulfur cluster binding protein
SMD44_RS38315	COG1024	Enoyl-CoA hydratase
SMD44_RS38320	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS38400	COG1070	Carbohydrate kinase
SMD44_RS38405	COG0588	phosphoglycerate mutase activity
SMD44_RS38465	COG4044	May play a role in the intracellular transport of hydrophobic ligands
SMD44_RS38510	COG3568	Endonuclease Exonuclease Phosphatase
SMD44_RS38530	COG1595	DNA-templated transcription, initiation
SMD44_RS38575	COG1271	oxidase subunit
SMD44_RS38580	COG0583	DNA-binding transcription factor activity
SMD44_RS38600	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SMD44_RS38615	COG4249	Peptidase C14 caspase catalytic subunit p20
SMD44_RS38615	COG2319	Wd-40 repeat
SMD44_RS38640	COG1120	ATPase activity
SMD44_RS38705	COG1132	(ABC) transporter
SMD44_RS38770	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SMD44_RS38775	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
SMD44_RS38785	COG0463	Glycosyl transferase, family 2
SMD44_RS38785	COG1216	Glycosyl transferase, family 2
SMD44_RS38810	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SMD44_RS38820	COG0438	transferase activity, transferring glycosyl groups
SMD44_RS38860	COG0438	transferase activity, transferring glycosyl groups
SMD44_RS38870	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SMD44_RS38890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD44_RS38960	COG1408	metallophosphoesterase
SMD44_RS38980	COG2226	methyltransferase
SMD44_RS38995	COG0309	Hydrogenase expression formation protein (HypE)
SMD44_RS39000	COG0409	Hydrogenase expression formation protein
SMD44_RS39090	COG1652	LysM domain
SMD44_RS39100	COG0071	Belongs to the small heat shock protein (HSP20) family
SMD44_RS39185	COG0589	response to stress
SMD44_RS39210	COG2319	Wd-40 repeat
SMD44_RS39210	COG4249	Peptidase C14 caspase catalytic subunit p20
SMD44_RS39240	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SMD44_RS39245	COG1454	alcohol dehydrogenase
SMD44_RS39245	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS39265	COG1012	belongs to the aldehyde dehydrogenase family
SMD44_RS39310	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SMD44_RS39390	COG2018	Roadblock/LC7 domain
SMD44_RS39405	COG1946	Acyl-CoA thioesterase
SMD44_RS39430	COG1301	dicarboxylic acid transport
SMD44_RS39435	COG0473	3-isopropylmalate dehydrogenase activity
SMD44_RS39475	COG1846	Transcriptional regulator
SMD44_RS39530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SMD44_RS39585	COG1088	dTDP-glucose 4,6-dehydratase activity
SMD44_RS39600	COG0515	serine threonine protein kinase
SMD44_RS39630	COG0318	PFAM AMP-dependent synthetase and ligase
SMD44_RS39635	COG1132	(ABC) transporter
SMD44_RS39640	COG2986	histidine ammonia-lyase
SMD44_RS39650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMD44_RS39745	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD44_RS39750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD44_RS39795	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD44_RS39800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD44_RS39805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD44_RS39810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD44_RS39815	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD44_RS39835	COG2080	2 iron, 2 sulfur cluster binding
SMD44_RS39850	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SMD44_RS39850	COG3608	succinylglutamate desuccinylase aspartoacylase
SMD44_RS39905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD44_RS39960	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SMD44_RS39970	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SMD44_RS39985	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SMD44_RS40005	COG0747	negative chemotaxis
SMD44_RS40010	COG0515	serine threonine protein kinase
SMD44_RS40070	COG2040	homocysteine
SMD44_RS40080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMD44_RS40090	COG0747	negative chemotaxis
SMD44_RS40095	COG1940	carbohydrate kinase activity
SMD44_RS40155	COG1902	pentaerythritol trinitrate reductase activity
SMD44_RS40160	COG0640	Transcriptional regulator
SMD44_RS40210	COG2197	response regulator
SMD44_RS40220	COG3540	Alkaline phosphatase
SMD44_RS40240	COG0740	serine-type endopeptidase activity
SMD44_RS40245	COG0740	serine-type endopeptidase activity
SMD44_RS40255	COG1396	sequence-specific DNA binding
SMD44_RS40300	COG2188	Transcriptional regulator
SMD44_RS40385	COG1802	Transcriptional regulator
SMD44_RS40400	COG4214	carbohydrate transport
SMD44_RS40430	COG1414	Transcriptional regulator
SMD44_RS40485	COG3485	protocatechuate 3,4-dioxygenase
SMD44_RS40490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD44_RS40560	COG1191	sigma factor activity
SMD44_RS40735	COG1472	Belongs to the glycosyl hydrolase 3 family
SMD44_RS40760	COG0494	nUDIX hydrolase
SMD44_RS40775	COG0483	inositol monophosphate 1-phosphatase activity
SMD44_RS40850	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
SMD44_RS40935	COG0142	geranyltranstransferase activity
SMD44_RS40955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD44_RS40960	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS40965	COG1169	isochorismate synthase
SMD44_RS40975	COG3433	isochorismatase activity
SMD44_RS40975	COG1535	isochorismatase
SMD44_RS40980	COG3433	isochorismatase activity
SMD44_RS40980	COG1535	isochorismatase
SMD44_RS41010	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SMD44_RS41020	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
SMD44_RS41110	COG1595	DNA-templated transcription, initiation
SMD44_RS41160	COG4977	sequence-specific DNA binding
SMD44_RS41170	COG1028	Short-chain dehydrogenase reductase Sdr
SMD44_RS41175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMD44_RS41205	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMD44_RS41210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMD44_RS41220	COG0477	Major facilitator Superfamily
SMD44_RS41250	COG0009	L-threonylcarbamoyladenylate synthase
SMD44_RS41365	COG0745	RESPONSE REGULATOR receiver
SMD44_RS41405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SMD44_RS41455	COG0515	serine threonine protein kinase
SMD44_RS41485	COG4585	Histidine kinase
SMD44_RS41510	COG0517	IMP dehydrogenase activity
SMD44_RS41510	COG0516	GMP reductase activity
SMD44_RS41515	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SMD44_RS41680	COG1132	(ABC) transporter
SMD44_RS41710	COG0542	response to heat
SMD44_RS41730	COG0189	ligase activity
SMD44_RS41770	COG1309	transcriptional regulator
SMD44_RS41795	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SMD44_RS41835	COG0488	(ABC) transporter
SMD44_RS41905	COG0515	serine threonine protein kinase
SMD44_RS41915	COG1132	(ABC) transporter
SMD44_RS41920	COG1132	(ABC) transporter
SMD44_RS42015	COG0745	RESPONSE REGULATOR receiver
SMD44_RS42125	COG0326	Molecular chaperone. Has ATPase activity
SMD44_RS42140	COG2124	cytochrome p450
SMD44_RS42160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD44_RS42175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD44_RS42330	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SMD44_RS42390	COG0328	RNA-DNA hybrid ribonuclease activity
SMD44_RS42430	COG0776	regulation of translation
SMD44_RS42445	COG0438	transferase activity, transferring glycosyl groups
SMD44_RS42505	COG1263	PTS System
SMD44_RS42515	COG1360	Flagellar Motor Protein
SMD44_RS42530	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMD44_RS42620	COG0515	serine threonine protein kinase
SMD44_RS42620	COG2815	serine threonine protein kinase
SMD44_RS42640	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SMD44_RS42680	COG1132	(ABC) transporter
SMD44_RS42690	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
SMD44_RS42705	COG4106	trans-aconitate 2-methyltransferase activity
SMD44_RS42710	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SMD44_RS42715	COG2176	DNA-directed DNA polymerase activity
SMD44_RS42740	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SMD44_RS42745	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SMD44_RS42755	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SMD44_RS42760	COG0302	gtp cyclohydrolase
SMD44_RS42765	COG0602	queuosine metabolic process
SMD44_RS42780	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMD44_RS42820	COG3387	PFAM Glycoside hydrolase 15-related
SMD44_RS42825	COG1011	Hydrolase
SMD44_RS42835	COG1960	acyl-CoA dehydrogenase activity
SMD44_RS42875	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SMD44_RS42875	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SMD44_RS42985	COG1475	DNA binding
SMD44_RS42990	COG3969	phosphoadenosine phosphosulfate
SMD44_RS43195	COG1073	alpha beta
SMD44_RS43195	COG2226	methyltransferase
SMD44_RS43390	COG0739	heme binding
SMD44_RS43390	COG0741	lytic transglycosylase activity
SMD44_RS43390	COG1196	nuclear chromosome segregation
SMD44_RS43555	COG0582	viral genome integration into host DNA
SMD44_RS43575	COG1857	crispr-associated protein
SMD44_RS43590	COG1518	maintenance of DNA repeat elements
SMD44_RS43595	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SMD44_RS43635	COG1484	DNA-dependent DNA replication
SMD44_RS43665	COG0741	lytic transglycosylase activity
SMD44_RS43665	COG1196	nuclear chromosome segregation
SMD44_RS43665	COG0739	heme binding
SMD44_RS43750	COG0105	UTP biosynthetic process
SMD44_RS43785	COG0456	acetyltransferase
SMD44_RS43845	COG1122	ATPase activity