locus-tag	class	description
DC74_RS00035	COG4977	sequence-specific DNA binding
DC74_RS00115	COG1278	Cold shock
DC74_RS00265	COG0662	Cupin 2, conserved barrel domain protein
DC74_RS00330	COG1012	belongs to the aldehyde dehydrogenase family
DC74_RS00380	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DC74_RS00420	COG2015	COG2015, Alkyl sulfatase and related hydrolases
DC74_RS00425	COG3118	belongs to the thioredoxin family
DC74_RS00475	COG0346	lactoylglutathione lyase activity
DC74_RS00480	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DC74_RS00490	COG0798	PFAM Bile acid sodium symporter
DC74_RS00495	COG0789	Transcriptional regulator
DC74_RS00505	COG2205	protein histidine kinase activity
DC74_RS00510	COG0745	RESPONSE REGULATOR receiver
DC74_RS00525	COG2755	lipolytic protein G-D-S-L family
DC74_RS00525	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DC74_RS00535	COG0154	amidase activity
DC74_RS00580	COG0384	phenazine biosynthesis protein PhzF
DC74_RS00595	COG1733	regulation of RNA biosynthetic process
DC74_RS00600	COG0596	Alpha beta hydrolase
DC74_RS00605	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS00615	COG0583	DNA-binding transcription factor activity
DC74_RS00635	COG0019	diaminopimelate decarboxylase activity
DC74_RS00650	COG0531	amino acid
DC74_RS00675	COG3293	Transposase
DC74_RS00735	COG1012	belongs to the aldehyde dehydrogenase family
DC74_RS00745	COG3483	tryptophan 2,3-dioxygenase activity
DC74_RS00760	COG2192	nodulation
DC74_RS00765	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DC74_RS00770	COG2226	methyltransferase
DC74_RS00800	COG4221	oxidoreductase activity
DC74_RS00875	COG2205	protein histidine kinase activity
DC74_RS00880	COG0745	RESPONSE REGULATOR receiver
DC74_RS00895	COG2267	carboxylic ester hydrolase activity
DC74_RS00900	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DC74_RS00920	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS00940	COG0154	amidase activity
DC74_RS00955	COG1733	regulation of RNA biosynthetic process
DC74_RS00960	COG0604	alcohol dehydrogenase
DC74_RS01010	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DC74_RS01040	COG1309	transcriptional regulator
DC74_RS01070	COG1620	l-lactate permease
DC74_RS01080	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DC74_RS01085	COG0247	lactate metabolic process
DC74_RS01085	COG0277	FAD linked oxidase domain protein
DC74_RS01120	COG3290	protein histidine kinase activity
DC74_RS01125	COG1309	transcriptional regulator
DC74_RS01140	COG2226	methyltransferase
DC74_RS01205	COG0517	IMP dehydrogenase activity
DC74_RS01205	COG0516	GMP reductase activity
DC74_RS01210	COG0517	IMP dehydrogenase activity
DC74_RS01210	COG0516	GMP reductase activity
DC74_RS01215	COG0516	GMP reductase activity
DC74_RS01215	COG0517	IMP dehydrogenase activity
DC74_RS01220	COG2326	polyphosphate kinase activity
DC74_RS01225	COG0745	RESPONSE REGULATOR receiver
DC74_RS01230	COG2205	protein histidine kinase activity
DC74_RS01370	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DC74_RS01375	COG2272	Belongs to the type-B carboxylesterase lipase family
DC74_RS01405	COG2814	Major facilitator Superfamily
DC74_RS01410	COG2124	cytochrome p450
DC74_RS01430	COG1595	DNA-templated transcription, initiation
DC74_RS01500	COG0583	DNA-binding transcription factor activity
DC74_RS01505	COG2814	Major facilitator Superfamily
DC74_RS01520	COG4585	Histidine kinase
DC74_RS01525	COG2197	response regulator
DC74_RS01555	COG1846	Transcriptional regulator
DC74_RS01605	COG3903	Transcriptional regulator
DC74_RS01605	COG3629	intracellular signal transduction
DC74_RS01655	COG4585	Histidine kinase
DC74_RS01670	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DC74_RS01690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DC74_RS01710	COG0494	nUDIX hydrolase
DC74_RS01800	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DC74_RS01805	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DC74_RS01810	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DC74_RS01850	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DC74_RS01850	COG0515	serine threonine protein kinase
DC74_RS01880	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DC74_RS01935	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DC74_RS01955	COG0477	Major facilitator Superfamily
DC74_RS01965	COG4941	Belongs to the sigma-70 factor family
DC74_RS01975	COG1064	alcohol dehydrogenase
DC74_RS01995	COG1611	Belongs to the LOG family
DC74_RS02045	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DC74_RS02070	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS02075	COG0477	Major facilitator Superfamily
DC74_RS02080	COG1819	glycosyl
DC74_RS02085	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DC74_RS02095	COG0328	RNA-DNA hybrid ribonuclease activity
DC74_RS02105	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DC74_RS02110	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DC74_RS02130	COG4977	sequence-specific DNA binding
DC74_RS02140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DC74_RS02165	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DC74_RS02265	COG1181	Belongs to the D-alanine--D-alanine ligase family
DC74_RS02320	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DC74_RS02330	COG3485	protocatechuate 3,4-dioxygenase
DC74_RS02360	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DC74_RS02365	COG3340	Belongs to the peptidase S51 family
DC74_RS02415	COG4585	Histidine kinase
DC74_RS02420	COG2197	response regulator
DC74_RS02425	COG1136	(ABC) transporter
DC74_RS02435	COG1090	epimerase
DC74_RS02445	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DC74_RS02470	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DC74_RS02485	COG4948	Mandelate Racemase Muconate Lactonizing
DC74_RS02490	COG0179	Fumarylacetoacetate (FAA) hydrolase
DC74_RS02500	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DC74_RS02505	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DC74_RS02510	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DC74_RS02535	COG2197	response regulator
DC74_RS02540	COG1942	4-Oxalocrotonate Tautomerase
DC74_RS02570	COG0590	tRNA wobble adenosine to inosine editing
DC74_RS02585	COG0583	DNA-binding transcription factor activity
DC74_RS02615	COG0488	(ABC) transporter
DC74_RS02620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DC74_RS02625	COG2318	DinB family
DC74_RS02630	COG0326	Molecular chaperone. Has ATPase activity
DC74_RS02670	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DC74_RS02675	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DC74_RS02680	COG1473	amidohydrolase
DC74_RS02685	COG0477	Major facilitator Superfamily
DC74_RS02695	COG2124	cytochrome p450
DC74_RS02700	COG0596	Alpha beta hydrolase
DC74_RS02720	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
DC74_RS02725	COG1414	Transcriptional regulator
DC74_RS02730	COG1461	Dihydroxyacetone kinase
DC74_RS02735	COG3185	4-Hydroxyphenylpyruvate dioxygenase
DC74_RS02755	COG0697	spore germination
DC74_RS02770	COG1254	Belongs to the acylphosphatase family
DC74_RS02785	COG2197	response regulator
DC74_RS02800	COG3340	Belongs to the peptidase S51 family
DC74_RS02820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DC74_RS02840	COG2267	carboxylic ester hydrolase activity
DC74_RS02845	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS02850	COG0656	L-ascorbic acid biosynthetic process
DC74_RS02855	COG2814	Major facilitator Superfamily
DC74_RS02875	COG0574	Belongs to the PEP-utilizing enzyme family
DC74_RS02875	COG3848	Pyruvate phosphate dikinase
DC74_RS02900	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DC74_RS02945	COG0640	Transcriptional regulator
DC74_RS03015	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS03020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DC74_RS03025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DC74_RS03030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DC74_RS03035	COG1335	isochorismatase
DC74_RS03060	COG5006	permease, DMT superfamily
DC74_RS03065	COG0583	DNA-binding transcription factor activity
DC74_RS03075	COG0738	Major facilitator superfamily
DC74_RS03090	COG0583	DNA-binding transcription factor activity
DC74_RS03095	COG0473	3-isopropylmalate dehydrogenase activity
DC74_RS03120	COG3321	synthase
DC74_RS03120	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS03120	COG0604	alcohol dehydrogenase
DC74_RS03195	COG1595	DNA-templated transcription, initiation
DC74_RS03210	COG1960	acyl-CoA dehydrogenase activity
DC74_RS03220	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DC74_RS03230	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS03240	COG0531	amino acid
DC74_RS03305	COG4977	sequence-specific DNA binding
DC74_RS03315	COG2124	cytochrome p450
DC74_RS03360	COG3655	Transcriptional regulator
DC74_RS03365	COG0644	oxidoreductase
DC74_RS03415	COG0702	epimerase
DC74_RS03440	COG3631	Ketosteroid isomerase-related protein
DC74_RS03445	COG0702	epimerase
DC74_RS03450	COG2345	Transcriptional regulator
DC74_RS03465	COG3033	Beta-eliminating lyase
DC74_RS03505	COG0513	Belongs to the DEAD box helicase family
DC74_RS03535	COG1196	nuclear chromosome segregation
DC74_RS03535	COG0741	lytic transglycosylase activity
DC74_RS03535	COG0739	heme binding
DC74_RS03610	COG3850	Histidine kinase
DC74_RS03635	COG0477	Major facilitator Superfamily
DC74_RS03640	COG2226	methyltransferase
DC74_RS03645	COG0488	(ABC) transporter
DC74_RS03670	COG1309	transcriptional regulator
DC74_RS03680	COG2272	Belongs to the type-B carboxylesterase lipase family
DC74_RS03685	COG3226	Transcriptional regulator
DC74_RS03705	COG2770	Histidine kinase
DC74_RS03705	COG2208	phosphoserine phosphatase activity
DC74_RS03725	COG1366	Belongs to the anti-sigma-factor antagonist family
DC74_RS03730	COG1191	sigma factor activity
DC74_RS03735	COG1819	glycosyl
DC74_RS03800	COG0701	Predicted permease
DC74_RS03805	COG0745	RESPONSE REGULATOR receiver
DC74_RS03810	COG2205	protein histidine kinase activity
DC74_RS03825	COG1959	2 iron, 2 sulfur cluster binding
DC74_RS03845	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS03850	COG0583	DNA-binding transcription factor activity
DC74_RS03870	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DC74_RS03900	COG1595	DNA-templated transcription, initiation
DC74_RS03905	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DC74_RS03915	COG2080	2 iron, 2 sulfur cluster binding
DC74_RS03920	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DC74_RS03925	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DC74_RS03955	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DC74_RS03965	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DC74_RS03970	COG2124	cytochrome p450
DC74_RS04005	COG3387	PFAM Glycoside hydrolase 15-related
DC74_RS04015	COG3293	Transposase
DC74_RS04035	COG0667	Aldo Keto reductase
DC74_RS04055	COG2226	methyltransferase
DC74_RS04070	COG2226	methyltransferase
DC74_RS04090	COG4221	oxidoreductase activity
DC74_RS04110	COG2318	DinB family
DC74_RS04135	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DC74_RS04155	COG2226	methyltransferase
DC74_RS04160	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DC74_RS04165	COG1993	acr, cog1993
DC74_RS04170	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DC74_RS04180	COG0531	amino acid
DC74_RS04195	COG1309	transcriptional regulator
DC74_RS04205	COG2084	Dehydrogenase
DC74_RS04210	COG2197	response regulator
DC74_RS04225	COG1115	amino acid carrier protein
DC74_RS04230	COG0745	RESPONSE REGULATOR receiver
DC74_RS04265	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DC74_RS04280	COG2329	Antibiotic biosynthesis monooxygenase
DC74_RS04300	COG0745	RESPONSE REGULATOR receiver
DC74_RS04315	COG2239	Acts as a magnesium transporter
DC74_RS04355	COG0181	hydroxymethylbilane synthase activity
DC74_RS04375	COG3293	Transposase
DC74_RS04400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DC74_RS04410	COG1794	racemase activity, acting on amino acids and derivatives
DC74_RS04455	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DC74_RS04475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DC74_RS04485	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DC74_RS04490	COG2124	cytochrome p450
DC74_RS04535	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS04540	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS04550	COG2409	Drug exporters of the RND superfamily
DC74_RS04570	COG1271	oxidase subunit
DC74_RS04575	COG1294	oxidase, subunit
DC74_RS04580	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS04610	COG0577	efflux transmembrane transporter activity
DC74_RS04615	COG1136	(ABC) transporter
DC74_RS04615	COG0577	efflux transmembrane transporter activity
DC74_RS04685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DC74_RS04705	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS04705	COG0604	alcohol dehydrogenase
DC74_RS04705	COG3321	synthase
DC74_RS04725	COG0492	ferredoxin-NADP+ reductase activity
DC74_RS04745	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS04760	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DC74_RS04775	COG2124	cytochrome p450
DC74_RS04780	COG0604	alcohol dehydrogenase
DC74_RS04785	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DC74_RS04790	COG1819	glycosyl
DC74_RS04795	COG0789	Transcriptional regulator
DC74_RS04800	COG1802	Transcriptional regulator
DC74_RS04805	COG0596	Alpha beta hydrolase
DC74_RS04815	COG3387	PFAM Glycoside hydrolase 15-related
DC74_RS04845	COG1902	pentaerythritol trinitrate reductase activity
DC74_RS04855	COG1335	isochorismatase
DC74_RS04865	COG0583	DNA-binding transcription factor activity
DC74_RS04870	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS04915	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DC74_RS04920	COG4988	ABC transporter
DC74_RS04930	COG1271	oxidase subunit
DC74_RS04935	COG0783	Belongs to the Dps family
DC74_RS04940	COG2814	Major facilitator Superfamily
DC74_RS04945	COG3619	membrane
DC74_RS04950	COG2259	Doxx family
DC74_RS04955	COG1335	isochorismatase
DC74_RS04965	COG0300	oxidoreductase activity
DC74_RS04970	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS05000	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DC74_RS05025	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DC74_RS05055	COG0367	asparagine synthase
DC74_RS05060	COG2814	Major facilitator Superfamily
DC74_RS05065	COG2608	mercury ion transmembrane transporter activity
DC74_RS05070	COG1120	ATPase activity
DC74_RS05075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DC74_RS05105	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS05110	COG1595	DNA-templated transcription, initiation
DC74_RS05170	COG4968	Prepilin-type N-terminal cleavage methylation domain
DC74_RS05175	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DC74_RS05180	COG1459	type II secretion system
DC74_RS05205	COG0202	RNA polymerase activity
DC74_RS05225	COG1124	(ABC) transporter
DC74_RS05230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DC74_RS05235	COG0601	transmembrane transport
DC74_RS05240	COG4166	transmembrane transport
DC74_RS05255	COG4948	Mandelate Racemase Muconate Lactonizing
DC74_RS05260	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DC74_RS05285	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DC74_RS05305	COG2132	Multicopper oxidase
DC74_RS05330	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DC74_RS05355	COG0477	Major facilitator Superfamily
DC74_RS05360	COG1960	acyl-CoA dehydrogenase activity
DC74_RS05365	COG1024	Enoyl-CoA hydratase
DC74_RS05370	COG1960	acyl-CoA dehydrogenase activity
DC74_RS05380	COG1960	acyl-CoA dehydrogenase activity
DC74_RS05385	COG0318	PFAM AMP-dependent synthetase and ligase
DC74_RS05395	COG0318	PFAM AMP-dependent synthetase and ligase
DC74_RS05405	COG2186	Transcriptional regulator
DC74_RS05435	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DC74_RS05490	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DC74_RS05505	COG4310	Domain of unknown function (DUF2172)
DC74_RS05515	COG1215	transferase activity, transferring glycosyl groups
DC74_RS05530	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DC74_RS05575	COG1937	Protein conserved in bacteria
DC74_RS05590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DC74_RS05665	COG0300	oxidoreductase activity
DC74_RS05670	COG1309	transcriptional regulator
DC74_RS05685	COG0069	glutamate synthase activity
DC74_RS05700	COG3903	Transcriptional regulator
DC74_RS05700	COG3629	intracellular signal transduction
DC74_RS05705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DC74_RS05715	COG3251	PFAM MbtH domain protein
DC74_RS05720	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DC74_RS05725	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DC74_RS05750	COG2208	phosphoserine phosphatase activity
DC74_RS05755	COG2172	sigma factor antagonist activity
DC74_RS05760	COG2172	sigma factor antagonist activity
DC74_RS05765	COG1366	Belongs to the anti-sigma-factor antagonist family
DC74_RS05770	COG1366	Belongs to the anti-sigma-factor antagonist family
DC74_RS05795	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
DC74_RS05815	COG2814	Major facilitator Superfamily
DC74_RS05820	COG0604	alcohol dehydrogenase
DC74_RS05835	COG3973	AAA domain
DC74_RS05870	COG2986	histidine ammonia-lyase
DC74_RS05875	COG0477	Major facilitator Superfamily
DC74_RS05895	COG0789	Transcriptional regulator
DC74_RS05900	COG0667	Aldo Keto reductase
DC74_RS05920	COG2205	protein histidine kinase activity
DC74_RS05925	COG0745	RESPONSE REGULATOR receiver
DC74_RS05995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DC74_RS05995	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS05995	COG3321	synthase
DC74_RS05995	COG4221	oxidoreductase activity
DC74_RS06005	COG3251	PFAM MbtH domain protein
DC74_RS06010	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DC74_RS06045	COG2135	peptidase activity
DC74_RS06055	COG2205	protein histidine kinase activity
DC74_RS06060	COG0745	RESPONSE REGULATOR receiver
DC74_RS06065	COG0577	efflux transmembrane transporter activity
DC74_RS06070	COG1136	(ABC) transporter
DC74_RS06095	COG1309	transcriptional regulator
DC74_RS06125	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DC74_RS06130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DC74_RS06165	COG0789	Transcriptional regulator
DC74_RS06190	COG0659	secondary active sulfate transmembrane transporter activity
DC74_RS06200	COG0583	DNA-binding transcription factor activity
DC74_RS06210	COG0515	serine threonine protein kinase
DC74_RS06210	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DC74_RS06215	COG0515	serine threonine protein kinase
DC74_RS06215	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DC74_RS06225	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DC74_RS06250	COG1113	amino acid transport
DC74_RS06255	COG3224	Antibiotic biosynthesis monooxygenase
DC74_RS06275	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DC74_RS06280	COG0477	Major facilitator Superfamily
DC74_RS06285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DC74_RS06300	COG0456	acetyltransferase
DC74_RS06300	COG1846	Transcriptional regulator
DC74_RS06310	COG0513	Belongs to the DEAD box helicase family
DC74_RS06315	COG1278	Cold shock
DC74_RS06355	COG3979	chitinase
DC74_RS06385	COG1472	Belongs to the glycosyl hydrolase 3 family
DC74_RS06390	COG2124	cytochrome p450
DC74_RS06415	COG3387	PFAM Glycoside hydrolase 15-related
DC74_RS06445	COG0300	oxidoreductase activity
DC74_RS06450	COG0189	ligase activity
DC74_RS06470	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS06485	COG2124	cytochrome p450
DC74_RS06500	COG0542	response to heat
DC74_RS06555	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DC74_RS06565	COG3290	protein histidine kinase activity
DC74_RS06570	COG4565	transcriptional regulatory protein
DC74_RS06585	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DC74_RS06610	COG0583	DNA-binding transcription factor activity
DC74_RS06620	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DC74_RS06625	COG0076	glutamate decarboxylase activity
DC74_RS06655	COG2186	Transcriptional regulator
DC74_RS06660	COG1027	Aspartate ammonia-lyase
DC74_RS06670	COG0640	Transcriptional regulator
DC74_RS06715	COG0529	Catalyzes the synthesis of activated sulfate
DC74_RS06725	COG0583	DNA-binding transcription factor activity
DC74_RS06785	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DC74_RS06810	COG2365	Tyrosine phosphatase family
DC74_RS06815	COG3321	synthase
DC74_RS06815	COG0604	alcohol dehydrogenase
DC74_RS06825	COG0604	alcohol dehydrogenase
DC74_RS06825	COG3321	synthase
DC74_RS06895	COG2197	response regulator
DC74_RS06900	COG4585	Histidine kinase
DC74_RS06905	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DC74_RS06915	COG0494	nUDIX hydrolase
DC74_RS06930	COG0531	amino acid
DC74_RS06940	COG0772	Belongs to the SEDS family
DC74_RS06970	COG0076	glutamate decarboxylase activity
DC74_RS06990	COG2124	cytochrome p450
DC74_RS07010	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DC74_RS07030	COG1309	transcriptional regulator
DC74_RS07045	COG2309	aminopeptidase activity
DC74_RS07075	COG1335	isochorismatase
DC74_RS07080	COG0596	Alpha beta hydrolase
DC74_RS07100	COG1653	transport
DC74_RS07150	COG2274	protein secretion by the type I secretion system
DC74_RS07165	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DC74_RS07165	COG1796	DNA polymerase
DC74_RS07170	COG0583	DNA-binding transcription factor activity
DC74_RS07175	COG0156	8-amino-7-oxononanoate synthase activity
DC74_RS07180	COG1063	alcohol dehydrogenase
DC74_RS07205	COG2318	DinB family
DC74_RS07240	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DC74_RS07245	COG5504	Zn-dependent protease
DC74_RS07265	COG0745	RESPONSE REGULATOR receiver
DC74_RS07270	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DC74_RS07270	COG1024	Enoyl-CoA hydratase
DC74_RS07285	COG0477	Major facilitator Superfamily
DC74_RS07320	COG3585	molybdate ion transport
DC74_RS07335	COG2080	2 iron, 2 sulfur cluster binding
DC74_RS07335	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DC74_RS07340	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DC74_RS07345	COG3835	regulator
DC74_RS07410	COG2015	COG2015, Alkyl sulfatase and related hydrolases
DC74_RS07435	COG0438	transferase activity, transferring glycosyl groups
DC74_RS07470	COG2226	methyltransferase
DC74_RS07485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DC74_RS07490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DC74_RS07515	COG0386	Belongs to the glutathione peroxidase family
DC74_RS07525	COG1132	(ABC) transporter
DC74_RS07530	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DC74_RS07540	COG1136	(ABC) transporter
DC74_RS07575	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DC74_RS07580	COG0667	Aldo Keto reductase
DC74_RS07610	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS07625	COG4585	Histidine kinase
DC74_RS07650	COG0596	Alpha beta hydrolase
DC74_RS07660	COG1733	regulation of RNA biosynthetic process
DC74_RS07670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DC74_RS07695	COG0740	serine-type endopeptidase activity
DC74_RS07700	COG0740	serine-type endopeptidase activity
DC74_RS07720	COG2186	Transcriptional regulator
DC74_RS07730	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DC74_RS07755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DC74_RS07770	COG0483	inositol monophosphate 1-phosphatase activity
DC74_RS07885	COG0477	Major facilitator Superfamily
DC74_RS07895	COG2186	Transcriptional regulator
DC74_RS07910	COG0778	Nitroreductase
DC74_RS07920	COG4106	trans-aconitate 2-methyltransferase activity
DC74_RS07930	COG2197	response regulator
DC74_RS07960	COG0318	PFAM AMP-dependent synthetase and ligase
DC74_RS07965	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DC74_RS07965	COG0825	malonyl-CoA metabolic process
DC74_RS07975	COG0697	spore germination
DC74_RS08075	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DC74_RS08075	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DC74_RS08085	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DC74_RS08105	COG1716	ATPase activity
DC74_RS08130	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DC74_RS08160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DC74_RS08170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DC74_RS08185	COG1177	transmembrane transport
DC74_RS08190	COG1176	ABC-type spermidine putrescine transport system, permease component I
DC74_RS08195	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DC74_RS08200	COG3842	ATPase activity
DC74_RS08210	COG4977	sequence-specific DNA binding
DC74_RS08225	COG0596	Alpha beta hydrolase
DC74_RS08250	COG2146	nitrite reductase [NAD(P)H] activity
DC74_RS08275	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DC74_RS08295	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DC74_RS08300	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DC74_RS08370	COG0259	pyridoxamine-phosphate oxidase activity
DC74_RS08395	COG1024	Enoyl-CoA hydratase
DC74_RS08420	COG0318	PFAM AMP-dependent synthetase and ligase
DC74_RS08440	COG2070	2-Nitropropane dioxygenase
DC74_RS08455	COG0515	serine threonine protein kinase
DC74_RS08465	COG1960	acyl-CoA dehydrogenase activity
DC74_RS08485	COG2226	methyltransferase
DC74_RS08495	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
DC74_RS08500	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DC74_RS08515	COG0456	acetyltransferase
DC74_RS08525	COG0587	DNA-directed DNA polymerase activity
DC74_RS08540	COG0596	Alpha beta hydrolase
DC74_RS08555	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DC74_RS08560	COG2188	Transcriptional regulator
DC74_RS08565	COG0477	Major facilitator Superfamily
DC74_RS08580	COG2233	PERMEase
DC74_RS08595	COG1278	Cold shock
DC74_RS08635	COG0395	ABC-type sugar transport system, permease component
DC74_RS08645	COG1793	dna ligase
DC74_RS08655	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DC74_RS08695	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS08715	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DC74_RS08720	COG0463	Glycosyl transferase, family 2
DC74_RS08735	COG0633	Ferredoxin
DC74_RS08735	COG3217	Mosc domain protein beta barrel domain protein
DC74_RS08755	COG0464	growth
DC74_RS08765	COG1349	DNA-binding transcription factor activity
DC74_RS08825	COG1940	carbohydrate kinase activity
DC74_RS08830	COG2223	nitrite transmembrane transporter activity
DC74_RS08840	COG2197	response regulator
DC74_RS08845	COG4585	Histidine kinase
DC74_RS08860	COG0445	tRNA wobble uridine modification
DC74_RS08870	COG0494	nUDIX hydrolase
DC74_RS08895	COG2318	DinB family
DC74_RS08900	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DC74_RS08940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DC74_RS08950	COG0584	glycerophosphoryl diester phosphodiesterase
DC74_RS08960	COG0765	amino acid transport
DC74_RS08965	COG1126	abc transporter atp-binding protein
DC74_RS08970	COG0456	acetyltransferase
DC74_RS08995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DC74_RS09000	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS09005	COG0076	glutamate decarboxylase activity
DC74_RS09015	COG0477	Major facilitator Superfamily
DC74_RS09020	COG0154	amidase activity
DC74_RS09025	COG1309	transcriptional regulator
DC74_RS09045	COG4221	oxidoreductase activity
DC74_RS09050	COG1131	(ABC) transporter
DC74_RS09095	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
DC74_RS09100	COG0179	Fumarylacetoacetate (FAA) hydrolase
DC74_RS09120	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DC74_RS09125	COG0028	Belongs to the TPP enzyme family
DC74_RS09140	COG2192	nodulation
DC74_RS09155	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DC74_RS09160	COG0148	phosphopyruvate hydratase activity
DC74_RS09200	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DC74_RS09205	COG0140	phosphoribosyl-ATP diphosphatase activity
DC74_RS09210	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DC74_RS09215	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DC74_RS09215	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DC74_RS09220	COG3201	nicotinamide mononucleotide transporter
DC74_RS09235	COG0702	epimerase
DC74_RS09240	COG1940	carbohydrate kinase activity
DC74_RS09240	COG1846	Transcriptional regulator
DC74_RS09245	COG0738	Major facilitator superfamily
DC74_RS09270	COG2233	PERMEase
DC74_RS09295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DC74_RS09305	COG0477	Major facilitator Superfamily
DC74_RS09320	COG0531	amino acid
DC74_RS09340	COG2390	Transcriptional regulator
DC74_RS09345	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DC74_RS09360	COG3209	COG3209 Rhs family protein
DC74_RS09380	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DC74_RS09400	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DC74_RS09425	COG0284	orotidine-5'-phosphate decarboxylase activity
DC74_RS09430	COG0167	dihydroorotate dehydrogenase activity
DC74_RS09435	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DC74_RS09440	COG0505	Belongs to the CarA family
DC74_RS09450	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DC74_RS09455	COG0540	Belongs to the ATCase OTCase family
DC74_RS09460	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DC74_RS09470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DC74_RS09475	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DC74_RS09480	COG0006	proline dipeptidase activity
DC74_RS09490	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DC74_RS09495	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DC74_RS09500	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DC74_RS09505	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DC74_RS09510	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DC74_RS09520	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DC74_RS09525	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DC74_RS09545	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DC74_RS09565	COG0124	histidyl-tRNA synthetase
DC74_RS09575	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DC74_RS09580	COG1196	nuclear chromosome segregation
DC74_RS09585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DC74_RS09590	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DC74_RS09595	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DC74_RS09600	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DC74_RS09610	COG2255	four-way junction helicase activity
DC74_RS09615	COG0632	four-way junction helicase activity
DC74_RS09620	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DC74_RS09625	COG0217	transcriptional regulatory protein
DC74_RS09630	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DC74_RS09635	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DC74_RS09645	COG0438	transferase activity, transferring glycosyl groups
DC74_RS09650	COG1560	Kdo2-lipid A biosynthetic process
DC74_RS09655	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DC74_RS09685	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DC74_RS09700	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DC74_RS09750	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DC74_RS09795	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DC74_RS09795	COG1648	precorrin-2 dehydrogenase activity
DC74_RS09820	COG1464	Belongs to the NlpA lipoprotein family
DC74_RS09825	COG2011	ABC-type metal ion transport system permease component
DC74_RS09850	COG0584	glycerophosphoryl diester phosphodiesterase
DC74_RS09865	COG0477	Major facilitator Superfamily
DC74_RS09875	COG0165	Argininosuccinate lyase
DC74_RS09880	COG0137	argininosuccinate synthase activity
DC74_RS09895	COG1438	arginine binding
DC74_RS09900	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DC74_RS09905	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DC74_RS09910	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DC74_RS09915	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DC74_RS09930	COG1091	dTDP-4-dehydrorhamnose reductase activity
DC74_RS09955	COG4106	trans-aconitate 2-methyltransferase activity
DC74_RS09975	COG0697	spore germination
DC74_RS09985	COG1649	PFAM Uncharacterised BCR, COG1649
DC74_RS10010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DC74_RS10030	COG1132	(ABC) transporter
DC74_RS10045	COG3293	Transposase
DC74_RS10080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DC74_RS10080	COG0072	phenylalanine-tRNA ligase activity
DC74_RS10085	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DC74_RS10090	COG5002	protein histidine kinase activity
DC74_RS10095	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DC74_RS10100	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DC74_RS10105	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DC74_RS10110	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DC74_RS10120	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DC74_RS10125	COG1404	Belongs to the peptidase S8 family
DC74_RS10145	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS10150	COG1012	belongs to the aldehyde dehydrogenase family
DC74_RS10155	COG0174	glutamine synthetase
DC74_RS10160	COG2186	Transcriptional regulator
DC74_RS10165	COG0531	amino acid
DC74_RS10170	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DC74_RS10185	COG2233	PERMEase
DC74_RS10205	COG4176	ABC-type proline glycine betaine transport system permease component
DC74_RS10210	COG0517	IMP dehydrogenase activity
DC74_RS10210	COG4175	Glycine betaine
DC74_RS10215	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DC74_RS10240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DC74_RS10250	COG2826	transposase and inactivated derivatives, IS30 family
DC74_RS10255	COG0805	protein transport
DC74_RS10260	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DC74_RS10290	COG0544	peptidyl-prolyl cis-trans isomerase activity
DC74_RS10295	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DC74_RS10305	COG1609	Transcriptional regulator
DC74_RS10310	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DC74_RS10315	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DC74_RS10325	COG4122	O-methyltransferase activity
DC74_RS10330	COG1222	aaa ATPase
DC74_RS10350	COG0517	IMP dehydrogenase activity
DC74_RS10350	COG1994	Peptidase M50
DC74_RS10360	COG2197	response regulator
DC74_RS10365	COG4166	transmembrane transport
DC74_RS10370	COG0747	negative chemotaxis
DC74_RS10375	COG0546	phosphoglycolate phosphatase activity
DC74_RS10380	COG0646	methionine synthase
DC74_RS10380	COG1410	methionine synthase
DC74_RS10385	COG1414	Transcriptional regulator
DC74_RS10390	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DC74_RS10395	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DC74_RS10400	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DC74_RS10405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DC74_RS10410	COG2186	Transcriptional regulator
DC74_RS10420	COG3618	amidohydrolase
DC74_RS10430	COG4211	Belongs to the binding-protein-dependent transport system permease family
DC74_RS10435	COG1129	ABC transporter
DC74_RS10445	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS10450	COG4948	Mandelate Racemase Muconate Lactonizing
DC74_RS10455	COG0215	cysteine-tRNA ligase activity
DC74_RS10475	COG0598	Magnesium transport protein CorA
DC74_RS10485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DC74_RS10490	COG0667	Aldo Keto reductase
DC74_RS10520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DC74_RS10535	COG0488	(ABC) transporter
DC74_RS10580	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DC74_RS10585	COG2149	membrane
DC74_RS10605	COG1960	acyl-CoA dehydrogenase activity
DC74_RS10615	COG0318	PFAM AMP-dependent synthetase and ligase
DC74_RS10625	COG3876	Protein conserved in bacteria
DC74_RS10650	COG0477	Major facilitator Superfamily
DC74_RS10700	COG1960	acyl-CoA dehydrogenase activity
DC74_RS10725	COG1309	transcriptional regulator
DC74_RS10730	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DC74_RS10735	COG2188	Transcriptional regulator
DC74_RS10740	COG2814	Major facilitator Superfamily
DC74_RS10740	COG0477	Major facilitator Superfamily
DC74_RS10765	COG3619	membrane
DC74_RS10775	COG1834	amidinotransferase
DC74_RS10780	COG1725	Transcriptional regulator
DC74_RS10785	COG0367	asparagine synthase
DC74_RS10790	COG2226	methyltransferase
DC74_RS10800	COG0604	alcohol dehydrogenase
DC74_RS10800	COG3321	synthase
DC74_RS10800	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS10810	COG1522	sequence-specific DNA binding
DC74_RS10815	COG0531	amino acid
DC74_RS10825	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DC74_RS10840	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS10860	COG0330	HflC and HflK could
DC74_RS10875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DC74_RS10880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DC74_RS10885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DC74_RS10890	COG1126	abc transporter atp-binding protein
DC74_RS10895	COG0765	amino acid transport
DC74_RS10905	COG0765	amino acid transport
DC74_RS10930	COG2018	Roadblock/LC7 domain
DC74_RS10935	COG5002	protein histidine kinase activity
DC74_RS10940	COG1799	cell septum assembly
DC74_RS10945	COG1960	acyl-CoA dehydrogenase activity
DC74_RS10950	COG0477	Major facilitator Superfamily
DC74_RS10960	COG0671	phosphoesterase, PA-phosphatase related
DC74_RS10970	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DC74_RS10980	COG0438	transferase activity, transferring glycosyl groups
DC74_RS10995	COG1160	GTP binding
DC74_RS11005	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DC74_RS11030	COG1187	pseudouridine synthase activity
DC74_RS11035	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DC74_RS11040	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DC74_RS11055	COG0686	Belongs to the AlaDH PNT family
DC74_RS11065	COG0494	nUDIX hydrolase
DC74_RS11070	COG0504	CTP synthase activity
DC74_RS11075	COG3387	PFAM Glycoside hydrolase 15-related
DC74_RS11100	COG0497	DNA recombination
DC74_RS11110	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DC74_RS11130	COG1120	ATPase activity
DC74_RS11135	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DC74_RS11140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DC74_RS11155	COG0647	UMP catabolic process
DC74_RS11170	COG3486	L-lysine 6-monooxygenase (NADPH) activity
DC74_RS11210	COG2094	Belongs to the DNA glycosylase MPG family
DC74_RS11220	COG1881	PFAM PEBP family protein
DC74_RS11245	COG1119	ATPase activity
DC74_RS11265	COG2197	response regulator
DC74_RS11270	COG4585	Histidine kinase
DC74_RS11280	COG3953	SLT domain
DC74_RS11280	COG5412	phage tail tape measure protein
DC74_RS11285	COG0842	Transport permease protein
DC74_RS11285	COG1131	(ABC) transporter
DC74_RS11285	COG1716	ATPase activity
DC74_RS11290	COG0560	Phosphoserine phosphatase
DC74_RS11290	COG3830	Belongs to the UPF0237 family
DC74_RS11310	COG2186	Transcriptional regulator
DC74_RS11315	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DC74_RS11320	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS11335	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DC74_RS11350	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DC74_RS11355	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DC74_RS11395	COG0300	oxidoreductase activity
DC74_RS11425	COG3387	PFAM Glycoside hydrolase 15-related
DC74_RS11455	COG1302	Protein conserved in bacteria
DC74_RS11465	COG1024	Enoyl-CoA hydratase
DC74_RS11475	COG0488	(ABC) transporter
DC74_RS11490	COG0235	Class ii aldolase
DC74_RS11510	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DC74_RS11515	COG1492	cobalamin metabolic process
DC74_RS11530	COG1797	cobyrinic acid a,c-diamide synthase activity
DC74_RS11555	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS11565	COG0640	Transcriptional regulator
DC74_RS11580	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DC74_RS11585	COG1917	Cupin 2, conserved barrel domain protein
DC74_RS11590	COG5285	phytanoyl-CoA dioxygenase
DC74_RS11595	COG1902	pentaerythritol trinitrate reductase activity
DC74_RS11610	COG2226	methyltransferase
DC74_RS11625	COG1414	Transcriptional regulator
DC74_RS11645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DC74_RS11650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DC74_RS11655	COG2261	transglycosylase associated protein
DC74_RS11665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DC74_RS11670	COG2226	methyltransferase
DC74_RS11690	COG2171	N-acyltransferase activity
DC74_RS11695	COG3226	Transcriptional regulator
DC74_RS11700	COG2076	Multidrug Resistance protein
DC74_RS11710	COG0822	iron-sulfur transferase activity
DC74_RS11715	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DC74_RS11720	COG0396	ATPase activity
DC74_RS11730	COG0719	Fe-S assembly protein
DC74_RS11745	COG1131	(ABC) transporter
DC74_RS11770	COG0109	protoheme IX farnesyltransferase activity
DC74_RS11775	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DC74_RS11780	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DC74_RS11795	COG0363	glucosamine-6-phosphate deaminase activity
DC74_RS11800	COG0166	Belongs to the GPI family
DC74_RS11815	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DC74_RS11820	COG0149	triose-phosphate isomerase activity
DC74_RS11825	COG0126	phosphoglycerate kinase activity
DC74_RS11830	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DC74_RS11835	COG1481	regulation of sporulation
DC74_RS11840	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DC74_RS11845	COG1660	Displays ATPase and GTPase activities
DC74_RS11850	COG0322	excinuclease ABC activity
DC74_RS11875	COG2814	Major facilitator Superfamily
DC74_RS11880	COG1063	alcohol dehydrogenase
DC74_RS11885	COG1609	Transcriptional regulator
DC74_RS11895	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DC74_RS11905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DC74_RS11935	COG0556	nucleotide-excision repair
DC74_RS11940	COG0584	glycerophosphoryl diester phosphodiesterase
DC74_RS12010	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DC74_RS12030	COG0237	dephospho-CoA kinase activity
DC74_RS12085	COG2050	protein possibly involved in aromatic compounds catabolism
DC74_RS12095	COG0559	Belongs to the binding-protein-dependent transport system permease family
DC74_RS12140	COG0737	Belongs to the 5'-nucleotidase family
DC74_RS12180	COG1470	cell adhesion involved in biofilm formation
DC74_RS12180	COG0366	Alpha amylase catalytic
DC74_RS12190	COG2197	response regulator
DC74_RS12220	COG2267	carboxylic ester hydrolase activity
DC74_RS12240	COG3467	pyridoxamine 5'-phosphate
DC74_RS12255	COG0640	Transcriptional regulator
DC74_RS12270	COG0067	glutamate synthase
DC74_RS12270	COG0069	glutamate synthase activity
DC74_RS12270	COG0070	glutamate synthase
DC74_RS12285	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DC74_RS12295	COG0159	tryptophan synthase activity
DC74_RS12300	COG0133	tryptophan synthase activity
DC74_RS12305	COG0134	indole-3-glycerol-phosphate synthase activity
DC74_RS12330	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DC74_RS12340	COG0583	DNA-binding transcription factor activity
DC74_RS12350	COG1053	succinate dehydrogenase
DC74_RS12355	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DC74_RS12360	COG0107	imidazoleglycerol-phosphate synthase activity
DC74_RS12365	COG0251	oxidation-reduction process
DC74_RS12370	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DC74_RS12375	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DC74_RS12385	COG0131	Imidazoleglycerol-phosphate dehydratase
DC74_RS12390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DC74_RS12395	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DC74_RS12410	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DC74_RS12430	COG1432	Conserved Protein
DC74_RS12435	COG0587	DNA-directed DNA polymerase activity
DC74_RS12485	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DC74_RS12500	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DC74_RS12505	COG3599	regulation of cell shape
DC74_RS12515	COG1799	cell septum assembly
DC74_RS12520	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DC74_RS12530	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DC74_RS12535	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DC74_RS12540	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DC74_RS12550	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DC74_RS12555	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DC74_RS12565	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DC74_RS12570	COG0768	penicillin binding
DC74_RS12580	COG0275	rRNA processing
DC74_RS12590	COG0714	Associated with various cellular activities
DC74_RS12610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DC74_RS12620	COG1131	(ABC) transporter
DC74_RS12620	COG1716	ATPase activity
DC74_RS12620	COG0842	Transport permease protein
DC74_RS12630	COG1309	transcriptional regulator
DC74_RS12640	COG1233	COG1233 Phytoene dehydrogenase and related
DC74_RS12655	COG0352	thiamine-phosphate diphosphorylase activity
DC74_RS12670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DC74_RS12670	COG2022	thiamine diphosphate biosynthetic process
DC74_RS12680	COG2022	thiamine diphosphate biosynthetic process
DC74_RS12685	COG0789	Transcriptional regulator
DC74_RS12695	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DC74_RS12700	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DC74_RS12705	COG2193	ferroxidase activity
DC74_RS12710	COG0243	molybdopterin cofactor binding
DC74_RS12715	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DC74_RS12725	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DC74_RS12730	COG0205	6-phosphofructokinase activity
DC74_RS12735	COG2197	response regulator
DC74_RS12765	COG1940	carbohydrate kinase activity
DC74_RS12775	COG0003	Pfam Anion-transporting ATPase
DC74_RS12795	COG0438	transferase activity, transferring glycosyl groups
DC74_RS12810	COG0791	NLP P60 protein
DC74_RS12870	COG2186	Transcriptional regulator
DC74_RS12875	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DC74_RS12880	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DC74_RS12885	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DC74_RS12890	COG0723	plastoquinol--plastocyanin reductase activity
DC74_RS12895	COG2010	Cytochrome c
DC74_RS12900	COG1845	cytochrome c oxidase, subunit III
DC74_RS12910	COG1376	ErfK ybiS ycfS ynhG family protein
DC74_RS12920	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DC74_RS12925	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DC74_RS12935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DC74_RS12950	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DC74_RS12975	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DC74_RS12980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DC74_RS12985	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DC74_RS12990	COG2197	response regulator
DC74_RS12995	COG4585	Histidine kinase
DC74_RS13030	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DC74_RS13040	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DC74_RS13045	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DC74_RS13050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DC74_RS13065	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DC74_RS13105	COG0321	lipoyl(octanoyl) transferase activity
DC74_RS13110	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DC74_RS13150	COG0318	PFAM AMP-dependent synthetase and ligase
DC74_RS13190	COG2197	response regulator
DC74_RS13235	COG0366	Alpha amylase catalytic
DC74_RS13240	COG3833	ABC-type maltose transport systems, permease component
DC74_RS13245	COG1175	transmembrane transport
DC74_RS13250	COG2182	Extracellular solute-binding protein
DC74_RS13255	COG0366	Alpha amylase catalytic
DC74_RS13260	COG1609	Transcriptional regulator
DC74_RS13270	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DC74_RS13285	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DC74_RS13290	COG0174	glutamine synthetase
DC74_RS13295	COG2267	carboxylic ester hydrolase activity
DC74_RS13305	COG2132	Multicopper oxidase
DC74_RS13310	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DC74_RS13310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DC74_RS13315	COG2814	Major facilitator Superfamily
DC74_RS13325	COG1309	transcriptional regulator
DC74_RS13330	COG0477	Major facilitator Superfamily
DC74_RS13335	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DC74_RS13355	COG1994	Peptidase M50
DC74_RS13375	COG1175	transmembrane transport
DC74_RS13385	COG2186	Transcriptional regulator
DC74_RS13390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DC74_RS13410	COG5398	heme oxygenase
DC74_RS13440	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DC74_RS13445	COG2814	Major facilitator Superfamily
DC74_RS13450	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS13520	COG0789	Transcriptional regulator
DC74_RS13535	COG3022	response to hydroperoxide
DC74_RS13540	COG0800	Aldolase
DC74_RS13555	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DC74_RS13565	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS13575	COG2030	dehydratase
DC74_RS13580	COG4585	Histidine kinase
DC74_RS13585	COG2197	response regulator
DC74_RS13595	COG0183	Belongs to the thiolase family
DC74_RS13600	COG1960	acyl-CoA dehydrogenase activity
DC74_RS13620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DC74_RS13645	COG0438	transferase activity, transferring glycosyl groups
DC74_RS13650	COG1309	transcriptional regulator
DC74_RS13685	COG3845	ABC transporter
DC74_RS13695	COG0183	Belongs to the thiolase family
DC74_RS13700	COG2124	cytochrome p450
DC74_RS13710	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DC74_RS13835	COG1072	(Pantothenic acid kinase))
DC74_RS13850	COG0596	Alpha beta hydrolase
DC74_RS13855	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
DC74_RS13865	COG2259	Doxx family
DC74_RS13895	COG2186	Transcriptional regulator
DC74_RS13910	COG1358	cellular component organization or biogenesis
DC74_RS13955	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DC74_RS13965	COG0477	Major facilitator Superfamily
DC74_RS13970	COG1309	transcriptional regulator
DC74_RS13985	COG4585	Histidine kinase
DC74_RS13990	COG2197	response regulator
DC74_RS14005	COG0667	Aldo Keto reductase
DC74_RS14010	COG0789	Transcriptional regulator
DC74_RS14035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DC74_RS14040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DC74_RS14045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DC74_RS14075	COG1309	transcriptional regulator
DC74_RS14085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DC74_RS14095	COG1172	Belongs to the binding-protein-dependent transport system permease family
DC74_RS14100	COG1129	ABC transporter
DC74_RS14105	COG1609	Transcriptional regulator
DC74_RS14110	COG1764	response to oxidative stress
DC74_RS14115	COG2130	NADP-dependent
DC74_RS14125	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DC74_RS14150	COG0500	methyltransferase
DC74_RS14190	COG1077	Cell shape determining protein MreB Mrl
DC74_RS14195	COG0588	phosphoglycerate mutase activity
DC74_RS14200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DC74_RS14260	COG0776	regulation of translation
DC74_RS14410	COG0105	UTP biosynthetic process
DC74_RS14420	COG0494	nUDIX hydrolase
DC74_RS14445	COG1476	TRANSCRIPTIONal
DC74_RS14545	COG2124	cytochrome p450
DC74_RS14585	COG1070	Carbohydrate kinase
DC74_RS14595	COG0358	DNA primase activity
DC74_RS14610	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DC74_RS14625	COG0243	molybdopterin cofactor binding
DC74_RS14630	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DC74_RS14660	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DC74_RS14690	COG0667	Aldo Keto reductase
DC74_RS14705	COG1473	amidohydrolase
DC74_RS14710	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS14720	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DC74_RS14725	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DC74_RS14725	COG2146	nitrite reductase [NAD(P)H] activity
DC74_RS14740	COG0531	amino acid
DC74_RS14750	COG1175	transmembrane transport
DC74_RS14755	COG0395	ABC-type sugar transport system, permease component
DC74_RS14760	COG2175	clavaminate synthase activity
DC74_RS14790	COG2015	COG2015, Alkyl sulfatase and related hydrolases
DC74_RS14795	COG0574	Belongs to the PEP-utilizing enzyme family
DC74_RS14795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DC74_RS14825	COG0477	Major facilitator Superfamily
DC74_RS14830	COG0667	Aldo Keto reductase
DC74_RS14840	COG0423	glycine-tRNA ligase activity
DC74_RS14850	COG1121	(ABC) transporter
DC74_RS14855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DC74_RS14875	COG1228	amidohydrolase
DC74_RS14880	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DC74_RS14885	COG1381	Involved in DNA repair and RecF pathway recombination
DC74_RS14925	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DC74_RS14945	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DC74_RS14960	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DC74_RS14975	COG1486	melibiose metabolic process
DC74_RS14990	COG4948	Mandelate Racemase Muconate Lactonizing
DC74_RS15000	COG1234	tRNA 3'-trailer cleavage
DC74_RS15005	COG0537	adenosine 5'-monophosphoramidase activity
DC74_RS15030	COG0484	heat shock protein binding
DC74_RS15035	COG1420	regulation of RNA biosynthetic process
DC74_RS15065	COG1022	Amp-dependent synthetase and ligase
DC74_RS15070	COG0481	GTPase activity
DC74_RS15075	COG0268	Binds directly to 16S ribosomal RNA
DC74_RS15105	COG1555	photosystem II stabilization
DC74_RS15110	COG1307	EDD domain protein, DegV family
DC74_RS15120	COG0495	leucyl-tRNA aminoacylation
DC74_RS15150	COG0588	phosphoglycerate mutase activity
DC74_RS15155	COG0799	negative regulation of ribosome biogenesis
DC74_RS15165	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DC74_RS15175	COG0501	Belongs to the peptidase M48B family
DC74_RS15185	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DC74_RS15195	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DC74_RS15205	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DC74_RS15210	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DC74_RS15215	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DC74_RS15255	COG0772	Belongs to the SEDS family
DC74_RS15260	COG0768	penicillin binding
DC74_RS15275	COG1077	Cell shape determining protein MreB Mrl
DC74_RS15280	COG0105	UTP biosynthetic process
DC74_RS15290	COG0285	dihydrofolate synthase activity
DC74_RS15295	COG0768	penicillin binding
DC74_RS15305	COG0525	valine-tRNA ligase activity
DC74_RS15315	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DC74_RS15320	COG0740	serine-type endopeptidase activity
DC74_RS15325	COG0740	serine-type endopeptidase activity
DC74_RS15330	COG0544	peptidyl-prolyl cis-trans isomerase activity
DC74_RS15355	COG0475	glutathione-regulated potassium exporter activity
DC74_RS15365	COG4552	Acetyltransferase involved in intracellular survival and related
DC74_RS15375	COG0698	ribose 5-phosphate isomerase
DC74_RS15380	COG1113	amino acid transport
DC74_RS15390	COG1113	amino acid transport
DC74_RS15395	COG1113	amino acid transport
DC74_RS15400	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DC74_RS15405	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DC74_RS15435	COG4266	Belongs to the allantoicase family
DC74_RS15480	COG0668	transmembrane transport
DC74_RS15490	COG1846	Transcriptional regulator
DC74_RS15490	COG1940	carbohydrate kinase activity
DC74_RS15500	COG1175	transmembrane transport
DC74_RS15505	COG0395	ABC-type sugar transport system, permease component
DC74_RS15510	COG1486	melibiose metabolic process
DC74_RS15525	COG2188	Transcriptional regulator
DC74_RS15535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DC74_RS15570	COG2346	COG2346, Truncated hemoglobins
DC74_RS15600	COG0629	single-stranded DNA binding
DC74_RS15635	COG2391	methyltransferase activity
DC74_RS15640	COG0515	serine threonine protein kinase
DC74_RS15640	COG2815	serine threonine protein kinase
DC74_RS15655	COG1077	Cell shape determining protein MreB Mrl
DC74_RS15665	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DC74_RS15680	COG1131	(ABC) transporter
DC74_RS15695	COG3962	Belongs to the TPP enzyme family
DC74_RS15700	COG3718	enzyme involved in inositol metabolism
DC74_RS15710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DC74_RS15720	COG0673	inositol 2-dehydrogenase activity
DC74_RS15725	COG2814	Major facilitator Superfamily
DC74_RS15745	COG0673	inositol 2-dehydrogenase activity
DC74_RS15760	COG2608	mercury ion transmembrane transporter activity
DC74_RS15770	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DC74_RS15785	COG0673	inositol 2-dehydrogenase activity
DC74_RS15790	COG1609	Transcriptional regulator
DC74_RS15800	COG1472	Belongs to the glycosyl hydrolase 3 family
DC74_RS15820	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DC74_RS15835	COG0028	Belongs to the TPP enzyme family
DC74_RS15890	COG1946	Acyl-CoA thioesterase
DC74_RS15900	COG1309	transcriptional regulator
DC74_RS15905	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DC74_RS15920	COG1960	acyl-CoA dehydrogenase activity
DC74_RS15935	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DC74_RS15940	COG0589	response to stress
DC74_RS15945	COG4977	sequence-specific DNA binding
DC74_RS15950	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DC74_RS15960	COG2910	NAD(P)H-binding
DC74_RS15970	COG3979	chitinase
DC74_RS16005	COG0297	glycogen (starch) synthase activity
DC74_RS16010	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DC74_RS16015	COG0438	transferase activity, transferring glycosyl groups
DC74_RS16070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DC74_RS16090	COG0154	amidase activity
DC74_RS16105	COG0765	amino acid transport
DC74_RS16110	COG0765	amino acid transport
DC74_RS16115	COG1126	abc transporter atp-binding protein
DC74_RS16130	COG0318	PFAM AMP-dependent synthetase and ligase
DC74_RS16135	COG3397	chitin binding
DC74_RS16140	COG2318	DinB family
DC74_RS16200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DC74_RS16205	COG2188	Transcriptional regulator
DC74_RS16215	COG0673	inositol 2-dehydrogenase activity
DC74_RS16225	COG0706	membrane insertase activity
DC74_RS16235	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DC74_RS16245	COG3764	Sortase (surface protein transpeptidase)
DC74_RS16280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DC74_RS16290	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DC74_RS16305	COG2205	protein histidine kinase activity
DC74_RS16335	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DC74_RS16345	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DC74_RS16350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DC74_RS16355	COG1263	PTS System
DC74_RS16360	COG1263	PTS System
DC74_RS16365	COG1234	tRNA 3'-trailer cleavage
DC74_RS16390	COG1113	amino acid transport
DC74_RS16400	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DC74_RS16410	COG1335	isochorismatase
DC74_RS16445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DC74_RS16450	COG0222	ribosome binding
DC74_RS16455	COG0494	nUDIX hydrolase
DC74_RS16485	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DC74_RS16490	COG0277	FAD linked oxidase domain protein
DC74_RS16495	COG3185	4-Hydroxyphenylpyruvate dioxygenase
DC74_RS16505	COG1174	glycine betaine transport
DC74_RS16515	COG1174	glycine betaine transport
DC74_RS16560	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DC74_RS16575	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DC74_RS16585	COG2814	Major facilitator Superfamily
DC74_RS16590	COG0583	DNA-binding transcription factor activity
DC74_RS16610	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DC74_RS16615	COG0776	regulation of translation
DC74_RS16625	COG3973	AAA domain
DC74_RS16645	COG2223	nitrite transmembrane transporter activity
DC74_RS16660	COG0583	DNA-binding transcription factor activity
DC74_RS16670	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DC74_RS16675	COG0793	Belongs to the peptidase S41A family
DC74_RS16680	COG2177	Part of the ABC transporter FtsEX involved in
DC74_RS16685	COG2884	Cell division ATP-binding protein ftsE
DC74_RS16700	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DC74_RS16705	COG0515	serine threonine protein kinase
DC74_RS16720	COG1653	transport
DC74_RS16725	COG1175	transmembrane transport
DC74_RS16730	COG0395	ABC-type sugar transport system, permease component
DC74_RS16745	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DC74_RS16780	COG0463	Glycosyl transferase, family 2
DC74_RS16800	COG1309	transcriptional regulator
DC74_RS16810	COG1388	LysM domain
DC74_RS16810	COG1134	teichoic acid transport
DC74_RS16815	COG2902	Dehydrogenase
DC74_RS16820	COG0546	phosphoglycolate phosphatase activity
DC74_RS16835	COG0653	protein targeting
DC74_RS16845	COG3214	Protein conserved in bacteria
DC74_RS16850	COG2197	response regulator
DC74_RS16855	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DC74_RS16865	COG0823	Involved in the tonB-independent uptake of proteins
DC74_RS16870	COG5000	phosphorelay sensor kinase activity
DC74_RS16870	COG5002	protein histidine kinase activity
DC74_RS16875	COG0745	RESPONSE REGULATOR receiver
DC74_RS16880	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DC74_RS16900	COG0714	Associated with various cellular activities
DC74_RS16940	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DC74_RS16950	COG1482	cell wall glycoprotein biosynthetic process
DC74_RS16960	COG2835	tetraacyldisaccharide 4'-kinase activity
DC74_RS16965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DC74_RS16995	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DC74_RS17000	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
DC74_RS17000	COG0778	Nitroreductase
DC74_RS17035	COG1316	TRANSCRIPTIONal
DC74_RS17045	COG1316	TRANSCRIPTIONal
DC74_RS17065	COG1316	TRANSCRIPTIONal
DC74_RS17085	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DC74_RS17095	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DC74_RS17130	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DC74_RS17160	COG2205	protein histidine kinase activity
DC74_RS17165	COG0745	RESPONSE REGULATOR receiver
DC74_RS17170	COG3104	oligopeptide transport
DC74_RS17200	COG1366	Belongs to the anti-sigma-factor antagonist family
DC74_RS17205	COG1191	sigma factor activity
DC74_RS17210	COG1228	amidohydrolase
DC74_RS17220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DC74_RS17225	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DC74_RS17240	COG1131	(ABC) transporter
DC74_RS17265	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DC74_RS17280	COG2755	lipolytic protein G-D-S-L family
DC74_RS17285	COG0183	Belongs to the thiolase family
DC74_RS17310	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DC74_RS17325	COG1136	(ABC) transporter
DC74_RS17325	COG0577	efflux transmembrane transporter activity
DC74_RS17330	COG1136	(ABC) transporter
DC74_RS17330	COG0577	efflux transmembrane transporter activity
DC74_RS17335	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DC74_RS17360	COG0148	phosphopyruvate hydratase activity
DC74_RS17375	COG2124	cytochrome p450
DC74_RS17385	COG2814	Major facilitator Superfamily
DC74_RS17420	COG0515	serine threonine protein kinase
DC74_RS17420	COG2815	serine threonine protein kinase
DC74_RS17450	COG2814	Major facilitator Superfamily
DC74_RS17480	COG4585	Histidine kinase
DC74_RS17490	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DC74_RS17495	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DC74_RS17500	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DC74_RS17505	COG0193	aminoacyl-tRNA hydrolase activity
DC74_RS17510	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DC74_RS17520	COG1309	transcriptional regulator
DC74_RS17525	COG4106	trans-aconitate 2-methyltransferase activity
DC74_RS17550	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DC74_RS17580	COG0488	(ABC) transporter
DC74_RS17615	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DC74_RS17620	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DC74_RS17630	COG0084	hydrolase, TatD family'
DC74_RS17655	COG0442	prolyl-tRNA aminoacylation
DC74_RS17675	COG1122	ATPase activity
DC74_RS17685	COG0310	cobalt ion transport
DC74_RS17695	COG0793	Belongs to the peptidase S41A family
DC74_RS17695	COG4946	Tricorn protease homolog
DC74_RS17705	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS17715	COG2072	flavoprotein involved in K transport
DC74_RS17720	COG0789	Transcriptional regulator
DC74_RS17725	COG0708	Exodeoxyribonuclease III
DC74_RS17730	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DC74_RS17770	COG1131	(ABC) transporter
DC74_RS17780	COG1725	Transcriptional regulator
DC74_RS17785	COG2205	protein histidine kinase activity
DC74_RS17795	COG0789	Transcriptional regulator
DC74_RS17825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DC74_RS17830	COG0315	cyclic pyranopterin monophosphate synthase activity
DC74_RS17830	COG0521	Mo-molybdopterin cofactor biosynthetic process
DC74_RS17835	COG0315	cyclic pyranopterin monophosphate synthase activity
DC74_RS17845	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DC74_RS17850	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DC74_RS17860	COG3263	regulation of cellular component size
DC74_RS17875	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DC74_RS17880	COG1970	mechanosensitive ion channel activity
DC74_RS17885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DC74_RS17895	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DC74_RS17900	COG2188	Transcriptional regulator
DC74_RS17905	COG0730	response to heat
DC74_RS17940	COG3191	aminopeptidase activity
DC74_RS17960	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DC74_RS17980	COG1105	Belongs to the carbohydrate kinase PfkB family
DC74_RS17985	COG1349	DNA-binding transcription factor activity
DC74_RS17995	COG1247	-acetyltransferase
DC74_RS18020	COG1846	Transcriptional regulator
DC74_RS18040	COG1309	transcriptional regulator
DC74_RS18065	COG0514	ATP-dependent DNA helicase (RecQ)
DC74_RS18070	COG2205	protein histidine kinase activity
DC74_RS18090	COG0640	Transcriptional regulator
DC74_RS18100	COG1686	Belongs to the peptidase S11 family
DC74_RS18125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DC74_RS18130	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS18145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DC74_RS18155	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DC74_RS18270	COG1024	Enoyl-CoA hydratase
DC74_RS18300	COG1309	transcriptional regulator
DC74_RS18310	COG1960	acyl-CoA dehydrogenase activity
DC74_RS18340	COG1024	Enoyl-CoA hydratase
DC74_RS18355	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DC74_RS18360	COG2271	Major facilitator Superfamily
DC74_RS18370	COG1960	acyl-CoA dehydrogenase activity
DC74_RS18375	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS18390	COG1960	acyl-CoA dehydrogenase activity
DC74_RS18395	COG1960	acyl-CoA dehydrogenase activity
DC74_RS18400	COG0318	PFAM AMP-dependent synthetase and ligase
DC74_RS18425	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DC74_RS18435	COG0516	GMP reductase activity
DC74_RS18445	COG1595	DNA-templated transcription, initiation
DC74_RS18460	COG0583	DNA-binding transcription factor activity
DC74_RS18470	COG4221	oxidoreductase activity
DC74_RS18480	COG0459	protein refolding
DC74_RS18485	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DC74_RS18490	COG0772	Belongs to the SEDS family
DC74_RS18505	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DC74_RS18530	COG0802	atpase or kinase
DC74_RS18540	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DC74_RS18550	COG0736	holo-[acyl-carrier-protein] synthase activity
DC74_RS18555	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DC74_RS18565	COG1072	(Pantothenic acid kinase))
DC74_RS18570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DC74_RS18575	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DC74_RS18580	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DC74_RS18590	COG0101	tRNA pseudouridine synthase activity
DC74_RS18595	COG0203	ribosomal protein L17
DC74_RS18600	COG0202	RNA polymerase activity
DC74_RS18605	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DC74_RS18610	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DC74_RS18615	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DC74_RS18620	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DC74_RS18625	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DC74_RS18635	COG0563	adenylate kinase activity
DC74_RS18645	COG0200	Binds to the 23S rRNA
DC74_RS18650	COG1841	ribosomal large subunit assembly
DC74_RS18655	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DC74_RS18660	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DC74_RS18665	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DC74_RS18670	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DC74_RS18675	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DC74_RS18680	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DC74_RS18685	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DC74_RS18690	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DC74_RS18695	COG0255	Belongs to the universal ribosomal protein uL29 family
DC74_RS18700	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DC74_RS18705	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DC74_RS18710	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DC74_RS18715	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DC74_RS18720	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DC74_RS18725	COG0089	rRNA binding
DC74_RS18730	COG0088	Forms part of the polypeptide exit tunnel
DC74_RS18735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DC74_RS18740	COG0051	transcription antitermination factor activity, RNA binding
DC74_RS18745	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DC74_RS18750	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DC74_RS18755	COG0049	tRNA binding
DC74_RS18760	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DC74_RS18770	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DC74_RS18775	COG0085	RNA polymerase activity
DC74_RS18780	COG0222	ribosome binding
DC74_RS18785	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DC74_RS18795	COG0081	regulation of translation
DC74_RS18800	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DC74_RS18805	COG0250	Participates in transcription elongation, termination and antitermination
DC74_RS18820	COG0436	Aminotransferase
DC74_RS18825	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DC74_RS18830	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DC74_RS18840	COG2030	dehydratase
DC74_RS18845	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DC74_RS18875	COG1666	GTP binding
DC74_RS18880	COG3304	Inner membrane component domain
DC74_RS18885	COG0501	Belongs to the peptidase M48B family
DC74_RS18890	COG1007	ATP synthesis coupled electron transport
DC74_RS18900	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DC74_RS18905	COG0713	ATP synthesis coupled electron transport
DC74_RS18910	COG0839	Belongs to the complex I subunit 6 family
DC74_RS18915	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DC74_RS18920	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DC74_RS18935	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DC74_RS18950	COG4585	Histidine kinase
DC74_RS18955	COG4585	Histidine kinase
DC74_RS18965	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DC74_RS18965	COG0674	pyruvate-flavodoxin oxidoreductase activity
DC74_RS18970	COG1013	pyruvate-flavodoxin oxidoreductase activity
DC74_RS18990	COG0142	geranyltranstransferase activity
DC74_RS19010	COG1007	ATP synthesis coupled electron transport
DC74_RS19020	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DC74_RS19025	COG0713	ATP synthesis coupled electron transport
DC74_RS19030	COG0839	Belongs to the complex I subunit 6 family
DC74_RS19035	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DC74_RS19040	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DC74_RS19045	COG1034	ATP synthesis coupled electron transport
DC74_RS19050	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DC74_RS19060	COG0649	NAD binding
DC74_RS19065	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DC74_RS19070	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DC74_RS19095	COG2226	methyltransferase
DC74_RS19105	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DC74_RS19120	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DC74_RS19125	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DC74_RS19130	COG1278	Cold shock
DC74_RS19135	COG1674	ftsk spoiiie
DC74_RS19150	COG1404	Belongs to the peptidase S8 family
DC74_RS19195	COG1309	transcriptional regulator
DC74_RS19205	COG1301	dicarboxylic acid transport
DC74_RS19220	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DC74_RS19230	COG0163	prenyltransferase activity
DC74_RS19250	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DC74_RS19255	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DC74_RS19295	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DC74_RS19300	COG1333	cytochrome c biogenesis protein
DC74_RS19305	COG0785	Cytochrome C biogenesis protein
DC74_RS19320	COG0406	alpha-ribazole phosphatase activity
DC74_RS19325	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DC74_RS19355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DC74_RS19360	COG1742	UPF0060 membrane protein
DC74_RS19375	COG1690	Belongs to the RtcB family
DC74_RS19400	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
DC74_RS19405	COG0018	arginyl-trna synthetase
DC74_RS19430	COG0113	porphobilinogen synthase activity
DC74_RS19435	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DC74_RS19435	COG1648	precorrin-2 dehydrogenase activity
DC74_RS19440	COG0181	hydroxymethylbilane synthase activity
DC74_RS19445	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DC74_RS19450	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DC74_RS19495	COG0123	including yeast histone deacetylase and acetoin utilization protein
DC74_RS19505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DC74_RS19525	COG1846	Transcriptional regulator
DC74_RS19540	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DC74_RS19565	COG0579	oxidoreductase
DC74_RS19570	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DC74_RS19610	COG0513	Belongs to the DEAD box helicase family
DC74_RS19650	COG1643	Atp-dependent helicase
DC74_RS19685	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DC74_RS19700	COG3119	arylsulfatase activity
DC74_RS19720	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DC74_RS19725	COG0047	phosphoribosylformylglycinamidine synthase activity
DC74_RS19730	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DC74_RS19755	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DC74_RS19760	COG2814	Major facilitator Superfamily
DC74_RS19765	COG0583	DNA-binding transcription factor activity
DC74_RS19780	COG0151	Belongs to the GarS family
DC74_RS19795	COG1802	Transcriptional regulator
DC74_RS19800	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DC74_RS19810	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DC74_RS19810	COG0515	serine threonine protein kinase
DC74_RS19815	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DC74_RS19830	COG1131	(ABC) transporter
DC74_RS19835	COG3559	Exporter of polyketide antibiotics
DC74_RS19840	COG2197	response regulator
DC74_RS19845	COG4585	Histidine kinase
DC74_RS19855	COG3844	kynureninase activity
DC74_RS19875	COG0477	Major facilitator Superfamily
DC74_RS19880	COG0191	fructose-bisphosphate aldolase activity
DC74_RS19885	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DC74_RS19900	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DC74_RS19925	COG0542	response to heat
DC74_RS19940	COG0789	Transcriptional regulator
DC74_RS19945	COG0484	heat shock protein binding
DC74_RS19950	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DC74_RS19955	COG0443	Heat shock 70 kDa protein
DC74_RS19960	COG0247	lactate metabolic process
DC74_RS19960	COG2181	nitrate reductase activity
DC74_RS19970	COG2755	lipolytic protein G-D-S-L family
DC74_RS19980	COG0717	Belongs to the dCTP deaminase family
DC74_RS20030	COG2301	Belongs to the HpcH HpaI aldolase family
DC74_RS20035	COG2301	Belongs to the HpcH HpaI aldolase family
DC74_RS20060	COG3629	intracellular signal transduction
DC74_RS20060	COG3903	Transcriptional regulator
DC74_RS20125	COG1316	TRANSCRIPTIONal
DC74_RS20170	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
DC74_RS20190	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DC74_RS20220	COG1174	glycine betaine transport
DC74_RS20225	COG1174	glycine betaine transport
DC74_RS20245	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DC74_RS20250	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DC74_RS20275	COG1960	acyl-CoA dehydrogenase activity
DC74_RS20280	COG1362	aminopeptidase activity
DC74_RS20285	COG3903	Transcriptional regulator
DC74_RS20285	COG3629	intracellular signal transduction
DC74_RS20325	COG2814	Major facilitator Superfamily
DC74_RS20345	COG0508	dehydrogenase complex catalyzes the overall conversion of
DC74_RS20350	COG0022	dehydrogenase e1 component
DC74_RS20375	COG0515	serine threonine protein kinase
DC74_RS20380	COG0515	serine threonine protein kinase
DC74_RS20400	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DC74_RS20410	COG0746	molybdenum cofactor guanylyltransferase activity
DC74_RS20430	COG1522	sequence-specific DNA binding
DC74_RS20435	COG1309	transcriptional regulator
DC74_RS20440	COG1250	3-hydroxyacyl-CoA dehydrogenase
DC74_RS20465	COG3396	Phenylacetate-CoA oxygenase
DC74_RS20470	COG3460	Phenylacetate-CoA oxygenase
DC74_RS20475	COG3396	Phenylacetate-CoA oxygenase
DC74_RS20480	COG2151	metal-sulfur cluster biosynthetic enzyme
DC74_RS20485	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DC74_RS20525	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DC74_RS20535	COG0583	DNA-binding transcription factor activity
DC74_RS20545	COG1716	ATPase activity
DC74_RS20550	COG1716	ATPase activity
DC74_RS20565	COG0768	penicillin binding
DC74_RS20570	COG0515	serine threonine protein kinase
DC74_RS20575	COG3764	Sortase (surface protein transpeptidase)
DC74_RS20580	COG3764	Sortase (surface protein transpeptidase)
DC74_RS20595	COG3764	Sortase (surface protein transpeptidase)
DC74_RS20610	COG0705	Rhomboid family
DC74_RS20660	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DC74_RS20665	COG0187	DNA topoisomerase II activity
DC74_RS20670	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
DC74_RS20675	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DC74_RS20680	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DC74_RS20685	COG0592	DNA-directed DNA polymerase activity
DC74_RS20695	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DC74_RS20700	COG0594	ribonuclease P activity
DC74_RS20705	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DC74_RS20710	COG0706	membrane insertase activity
DC74_RS20720	COG0357	Ribosomal RNA small subunit methyltransferase G
DC74_RS20725	COG1192	Involved in chromosome partitioning
DC74_RS20740	COG3118	belongs to the thioredoxin family
DC74_RS20745	COG0492	ferredoxin-NADP+ reductase activity
DC74_RS20755	COG2815	serine threonine protein kinase
DC74_RS20755	COG0515	serine threonine protein kinase
DC74_RS20760	COG0728	peptidoglycan biosynthetic process
DC74_RS20770	COG0617	tRNA 3'-terminal CCA addition
DC74_RS20785	COG1260	myo-inositol-1-phosphate synthase
DC74_RS20795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DC74_RS20795	COG4499	WXG100 protein secretion system (Wss), protein YukC
DC74_RS20820	COG0360	Binds together with S18 to 16S ribosomal RNA
DC74_RS20825	COG0629	single-stranded DNA binding
DC74_RS20830	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DC74_RS20835	COG0359	binds to the 23S rRNA
DC74_RS20850	COG0305	Participates in initiation and elongation during chromosome replication
DC74_RS20855	COG1733	regulation of RNA biosynthetic process
DC74_RS20875	COG0789	Transcriptional regulator
DC74_RS20875	COG4978	Transcriptional regulator
DC74_RS20885	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DC74_RS20905	COG1846	Transcriptional regulator
DC74_RS20940	COG0626	cystathionine gamma-synthase activity
DC74_RS20945	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DC74_RS20950	COG1950	PFAM Membrane protein of
DC74_RS20955	COG0662	Cupin 2, conserved barrel domain protein
DC74_RS20980	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DC74_RS20990	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DC74_RS20995	COG1609	Transcriptional regulator
DC74_RS21000	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DC74_RS21010	COG1271	oxidase subunit
DC74_RS21015	COG1294	oxidase, subunit
DC74_RS21020	COG4988	ABC transporter
DC74_RS21030	COG0561	phosphatase activity
DC74_RS21040	COG0501	Belongs to the peptidase M48B family
DC74_RS21050	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
DC74_RS21065	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
DC74_RS21070	COG0789	Transcriptional regulator
DC74_RS21115	COG2807	transmembrane transport
DC74_RS21120	COG2186	Transcriptional regulator
DC74_RS21140	COG0789	Transcriptional regulator
DC74_RS21145	COG0583	DNA-binding transcription factor activity
DC74_RS21165	COG0561	phosphatase activity
DC74_RS21170	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DC74_RS21180	COG2837	iron assimilation
DC74_RS21185	COG2372	response to copper ion
DC74_RS21265	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS21275	COG0006	proline dipeptidase activity
DC74_RS21295	COG0653	protein targeting
DC74_RS21325	COG1846	Transcriptional regulator
DC74_RS21330	COG0697	spore germination
DC74_RS21350	COG1960	acyl-CoA dehydrogenase activity
DC74_RS21360	COG1960	acyl-CoA dehydrogenase activity
DC74_RS21370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DC74_RS21375	COG1595	DNA-templated transcription, initiation
DC74_RS21390	COG3437	response regulator, receiver
DC74_RS21395	COG3437	response regulator, receiver
DC74_RS21395	COG4999	Histidine kinase
DC74_RS21395	COG3850	Histidine kinase
DC74_RS21395	COG2205	protein histidine kinase activity
DC74_RS21410	COG0318	PFAM AMP-dependent synthetase and ligase
DC74_RS21465	COG2249	NAD(P)H dehydrogenase (quinone) activity
DC74_RS21490	COG0745	RESPONSE REGULATOR receiver
DC74_RS21495	COG2205	protein histidine kinase activity
DC74_RS21505	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DC74_RS21505	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DC74_RS21510	COG0477	Major facilitator Superfamily
DC74_RS21530	COG2353	YceI-like domain
DC74_RS21565	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DC74_RS21585	COG1191	sigma factor activity
DC74_RS21590	COG1191	sigma factor activity
DC74_RS21625	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS21630	COG0583	DNA-binding transcription factor activity
DC74_RS21640	COG0590	tRNA wobble adenosine to inosine editing
DC74_RS21650	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DC74_RS21685	COG0523	cobalamin synthesis protein
DC74_RS21695	COG1064	alcohol dehydrogenase
DC74_RS21720	COG2268	Band 7 protein
DC74_RS21795	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DC74_RS21800	COG1834	amidinotransferase
DC74_RS21810	COG2188	Transcriptional regulator
DC74_RS21815	COG0477	Major facilitator Superfamily
DC74_RS21820	COG0402	S-adenosylhomocysteine deaminase activity
DC74_RS21840	COG1595	DNA-templated transcription, initiation
DC74_RS21880	COG1132	(ABC) transporter
DC74_RS21910	COG2188	Transcriptional regulator
DC74_RS21930	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DC74_RS21935	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DC74_RS21955	COG1595	DNA-templated transcription, initiation
DC74_RS21975	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DC74_RS21985	COG0339	signal peptide processing
DC74_RS21990	COG2319	Wd-40 repeat
DC74_RS21990	COG4249	Peptidase C14 caspase catalytic subunit p20
DC74_RS22000	COG1408	metallophosphoesterase
DC74_RS22010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DC74_RS22020	COG0003	Pfam Anion-transporting ATPase
DC74_RS22040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DC74_RS22070	COG2267	carboxylic ester hydrolase activity
DC74_RS22080	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DC74_RS22085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DC74_RS22150	COG1111	helicase
DC74_RS22150	COG1205	dead DEAH box helicase
DC74_RS22155	COG1366	Belongs to the anti-sigma-factor antagonist family
DC74_RS22165	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DC74_RS22175	COG2890	protein-(glutamine-N5) methyltransferase activity
DC74_RS22200	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DC74_RS22200	COG1754	DNA topoisomerase type I activity
DC74_RS22205	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DC74_RS22210	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DC74_RS22225	COG0584	glycerophosphoryl diester phosphodiesterase
DC74_RS22230	COG3594	Acyltransferase
DC74_RS22245	COG1349	DNA-binding transcription factor activity
DC74_RS22255	COG1309	transcriptional regulator
DC74_RS22260	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DC74_RS22260	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DC74_RS22300	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DC74_RS22300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DC74_RS22310	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DC74_RS22315	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DC74_RS22320	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DC74_RS22325	COG0254	rRNA binding
DC74_RS22335	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DC74_RS22340	COG0640	Transcriptional regulator
DC74_RS22365	COG1012	belongs to the aldehyde dehydrogenase family
DC74_RS22370	COG2318	DinB family
DC74_RS22380	COG0076	glutamate decarboxylase activity
DC74_RS22385	COG0655	NAD(P)H dehydrogenase (quinone) activity
DC74_RS22395	COG0789	Transcriptional regulator
DC74_RS22400	COG0393	Putative heavy-metal-binding
DC74_RS22405	COG0586	Pfam SNARE associated Golgi protein
DC74_RS22415	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DC74_RS22430	COG0037	tRNA processing
DC74_RS22445	COG0302	gtp cyclohydrolase
DC74_RS22455	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DC74_RS22455	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DC74_RS22470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DC74_RS22475	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DC74_RS22485	COG0517	IMP dehydrogenase activity
DC74_RS22485	COG1125	glycine betaine transport
DC74_RS22490	COG1174	glycine betaine transport
DC74_RS22495	COG1174	glycine betaine transport
DC74_RS22500	COG1732	Glycine betaine
DC74_RS22515	COG0649	NAD binding
DC74_RS22525	COG4585	Histidine kinase
DC74_RS22530	COG2197	response regulator
DC74_RS22540	COG0640	Transcriptional regulator
DC74_RS22550	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
DC74_RS22560	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DC74_RS22565	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DC74_RS22575	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DC74_RS22595	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DC74_RS22615	COG0739	heme binding
DC74_RS22650	COG2205	protein histidine kinase activity
DC74_RS22655	COG0745	RESPONSE REGULATOR receiver
DC74_RS22665	COG1595	DNA-templated transcription, initiation
DC74_RS22670	COG1194	a g-specific adenine glycosylase
DC74_RS22680	COG0671	phosphoesterase, PA-phosphatase related
DC74_RS22700	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
DC74_RS22720	COG0248	Ppx GppA phosphatase
DC74_RS22725	COG1082	Xylose isomerase domain protein TIM barrel
DC74_RS22730	COG0129	dihydroxy-acid dehydratase activity
DC74_RS22760	COG1595	DNA-templated transcription, initiation
DC74_RS22770	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DC74_RS22775	COG0180	Tryptophanyl-tRNA synthetase
DC74_RS22825	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DC74_RS22830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DC74_RS22840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DC74_RS22855	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS22900	COG0739	heme binding
DC74_RS22900	COG0741	lytic transglycosylase activity
DC74_RS22900	COG1196	nuclear chromosome segregation
DC74_RS22905	COG0671	phosphoesterase, PA-phosphatase related
DC74_RS22910	COG0277	FAD linked oxidase domain protein
DC74_RS22930	COG1937	Protein conserved in bacteria
DC74_RS22940	COG0306	phosphate transporter
DC74_RS23045	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS23055	COG0754	glutathionylspermidine amidase activity
DC74_RS23060	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DC74_RS23065	COG2890	protein-(glutamine-N5) methyltransferase activity
DC74_RS23070	COG0667	Aldo Keto reductase
DC74_RS23090	COG1733	regulation of RNA biosynthetic process
DC74_RS23095	COG0431	NADPH-dependent FMN reductase
DC74_RS23115	COG1490	D-aminoacyl-tRNA deacylase activity
DC74_RS23120	COG0354	folic acid binding
DC74_RS23135	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DC74_RS23140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DC74_RS23145	COG3485	protocatechuate 3,4-dioxygenase
DC74_RS23170	COG2897	thiosulfate sulfurtransferase activity
DC74_RS23200	COG0745	RESPONSE REGULATOR receiver
DC74_RS23205	COG1609	Transcriptional regulator
DC74_RS23210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DC74_RS23215	COG0745	RESPONSE REGULATOR receiver
DC74_RS23220	COG2205	protein histidine kinase activity
DC74_RS23230	COG0737	Belongs to the 5'-nucleotidase family
DC74_RS23235	COG0456	acetyltransferase
DC74_RS23245	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DC74_RS23255	COG0494	nUDIX hydrolase
DC74_RS23255	COG0406	alpha-ribazole phosphatase activity
DC74_RS23270	COG0438	transferase activity, transferring glycosyl groups
DC74_RS23285	COG0588	phosphoglycerate mutase activity
DC74_RS23295	COG5002	protein histidine kinase activity
DC74_RS23310	COG1329	Transcriptional regulator
DC74_RS23315	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DC74_RS23320	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DC74_RS23330	COG0215	cysteine-tRNA ligase activity
DC74_RS23345	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DC74_RS23355	COG3842	ATPase activity
DC74_RS23380	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DC74_RS23385	COG0582	viral genome integration into host DNA
DC74_RS23395	COG0667	Aldo Keto reductase
DC74_RS23485	COG1228	amidohydrolase
DC74_RS23490	COG1940	carbohydrate kinase activity
DC74_RS23515	COG3336	cytochrome c oxidase
DC74_RS23520	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DC74_RS23525	COG0463	Glycosyl transferase, family 2
DC74_RS23540	COG1278	Cold shock
DC74_RS23570	COG1263	PTS System
DC74_RS23570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DC74_RS23575	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DC74_RS23620	COG3142	Participates in the control of copper homeostasis
DC74_RS23630	COG3973	AAA domain
DC74_RS23645	COG1061	Type III restriction enzyme res subunit
DC74_RS23665	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DC74_RS23670	COG1120	ATPase activity
DC74_RS23675	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DC74_RS23680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DC74_RS23695	COG1278	Cold shock
DC74_RS23700	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DC74_RS23705	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DC74_RS23760	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DC74_RS23770	COG2252	PERMEase
DC74_RS23795	COG0667	Aldo Keto reductase
DC74_RS23820	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DC74_RS23835	COG0277	FAD linked oxidase domain protein
DC74_RS23835	COG0247	lactate metabolic process
DC74_RS23845	COG0583	DNA-binding transcription factor activity
DC74_RS23850	COG5006	permease, DMT superfamily
DC74_RS23865	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DC74_RS23880	COG0318	PFAM AMP-dependent synthetase and ligase
DC74_RS23900	COG0259	pyridoxamine-phosphate oxidase activity
DC74_RS23910	COG4821	SIS domain
DC74_RS23920	COG2945	thiolester hydrolase activity
DC74_RS23920	COG0596	Alpha beta hydrolase
DC74_RS23945	COG1131	(ABC) transporter
DC74_RS24025	COG0515	serine threonine protein kinase
DC74_RS24030	COG1012	belongs to the aldehyde dehydrogenase family
DC74_RS24050	COG0519	Catalyzes the synthesis of GMP from XMP
DC74_RS24050	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DC74_RS24055	COG2084	Dehydrogenase
DC74_RS24330	COG2815	serine threonine protein kinase
DC74_RS24330	COG0515	serine threonine protein kinase
DC74_RS24340	COG2197	response regulator
DC74_RS24370	COG0739	heme binding
DC74_RS24380	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DC74_RS24395	COG0714	Associated with various cellular activities
DC74_RS24405	COG3552	Protein containing von Willebrand factor type A (VWA) domain
DC74_RS24525	COG0045	succinate-CoA ligase (ADP-forming) activity
DC74_RS24555	COG0138	bifunctional purine biosynthesis protein purh
DC74_RS24570	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DC74_RS24580	COG0039	L-malate dehydrogenase activity
DC74_RS24610	COG1012	belongs to the aldehyde dehydrogenase family
DC74_RS24620	COG4175	Glycine betaine
DC74_RS24620	COG0517	IMP dehydrogenase activity
DC74_RS24655	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DC74_RS24700	COG1295	ribonuclease BN
DC74_RS24710	COG0180	Tryptophanyl-tRNA synthetase
DC74_RS24715	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DC74_RS24730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DC74_RS24735	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DC74_RS24740	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DC74_RS24780	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DC74_RS24785	COG1053	succinate dehydrogenase
DC74_RS24795	COG2009	succinate dehydrogenase
DC74_RS24825	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DC74_RS24825	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DC74_RS24840	COG3265	gluconokinase activity
DC74_RS24880	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DC74_RS24890	COG1216	Glycosyl transferase, family 2
DC74_RS24905	COG2089	acid synthase
DC74_RS24915	COG1473	amidohydrolase
DC74_RS24915	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DC74_RS24920	COG1744	ABC transporter substrate-binding protein PnrA-like
DC74_RS24925	COG3845	ABC transporter
DC74_RS24930	COG4603	Belongs to the binding-protein-dependent transport system permease family
DC74_RS24935	COG1079	Belongs to the binding-protein-dependent transport system permease family
DC74_RS24950	COG2814	Major facilitator Superfamily
DC74_RS24955	COG0583	DNA-binding transcription factor activity
DC74_RS24965	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DC74_RS24990	COG2205	protein histidine kinase activity
DC74_RS24995	COG0745	RESPONSE REGULATOR receiver
DC74_RS25000	COG1595	DNA-templated transcription, initiation
DC74_RS25015	COG1012	belongs to the aldehyde dehydrogenase family
DC74_RS25020	COG1012	belongs to the aldehyde dehydrogenase family
DC74_RS25025	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DC74_RS25055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DC74_RS25090	COG4770	biotin carboxylase activity
DC74_RS25105	COG0424	maF-like protein
DC74_RS25115	COG2365	Tyrosine phosphatase family
DC74_RS25120	COG0768	penicillin binding
DC74_RS25130	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DC74_RS25140	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DC74_RS25145	COG1024	Enoyl-CoA hydratase
DC74_RS25155	COG2986	histidine ammonia-lyase
DC74_RS25170	COG1376	ErfK ybiS ycfS ynhG family protein
DC74_RS25180	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS25205	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DC74_RS25235	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DC74_RS25250	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DC74_RS25260	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DC74_RS25310	COG0604	alcohol dehydrogenase
DC74_RS25315	COG0154	amidase activity
DC74_RS25320	COG0789	Transcriptional regulator
DC74_RS25335	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DC74_RS25350	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
DC74_RS25365	COG1414	Transcriptional regulator
DC74_RS25370	COG0251	oxidation-reduction process
DC74_RS25375	COG2610	gluconate transmembrane transporter activity
DC74_RS25475	COG0667	Aldo Keto reductase
DC74_RS25480	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DC74_RS25485	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DC74_RS25500	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DC74_RS25505	COG0450	alkyl hydroperoxide reductase
DC74_RS25540	COG1136	(ABC) transporter
DC74_RS25550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DC74_RS25575	COG0114	fumarate hydratase activity
DC74_RS25600	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DC74_RS25600	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DC74_RS25625	COG0778	Nitroreductase
DC74_RS25630	COG1722	exodeoxyribonuclease VII activity
DC74_RS25635	COG1570	exodeoxyribonuclease VII activity
DC74_RS25645	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DC74_RS25660	COG0012	GTP binding
DC74_RS25670	COG0582	viral genome integration into host DNA
DC74_RS25680	COG0210	DNA helicase
DC74_RS25710	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DC74_RS25725	COG0582	viral genome integration into host DNA
DC74_RS25750	COG0531	amino acid
DC74_RS25775	COG0402	S-adenosylhomocysteine deaminase activity
DC74_RS25785	COG1053	succinate dehydrogenase
DC74_RS25805	COG1217	gtp-binding protein TYPA
DC74_RS25810	COG4166	transmembrane transport
DC74_RS25815	COG0601	transmembrane transport
DC74_RS25820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DC74_RS25825	COG0444	Belongs to the ABC transporter superfamily
DC74_RS25830	COG4608	Belongs to the ABC transporter superfamily
DC74_RS25835	COG4608	Belongs to the ABC transporter superfamily
DC74_RS25840	COG0444	Belongs to the ABC transporter superfamily
DC74_RS25845	COG0601	transmembrane transport
DC74_RS25850	COG4166	transmembrane transport
DC74_RS25855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DC74_RS25870	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DC74_RS25885	COG1131	(ABC) transporter
DC74_RS25895	COG4585	Histidine kinase
DC74_RS25900	COG2197	response regulator
DC74_RS25940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DC74_RS25945	COG1611	Belongs to the LOG family
DC74_RS25950	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DC74_RS25960	COG0519	Catalyzes the synthesis of GMP from XMP
DC74_RS25965	COG1024	Enoyl-CoA hydratase
DC74_RS25970	COG4122	O-methyltransferase activity
DC74_RS25975	COG1595	DNA-templated transcription, initiation
DC74_RS25985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DC74_RS25990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DC74_RS26025	COG0598	Magnesium transport protein CorA
DC74_RS26035	COG2814	Major facilitator Superfamily
DC74_RS26050	COG2095	MarC family integral membrane protein
DC74_RS26055	COG1432	Conserved Protein
DC74_RS26180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DC74_RS26220	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DC74_RS26265	COG3480	Lon protease (S16) C-terminal proteolytic domain
DC74_RS26275	COG1615	UPF0182 protein
DC74_RS26315	COG0753	catalase activity
DC74_RS26325	COG0483	inositol monophosphate 1-phosphatase activity
DC74_RS26335	COG2076	Multidrug Resistance protein
DC74_RS26340	COG1162	GTPase activity
DC74_RS26345	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DC74_RS26355	COG2135	peptidase activity
DC74_RS26365	COG1595	DNA-templated transcription, initiation
DC74_RS26370	COG5662	AntiSigma factor
DC74_RS26390	COG0242	peptide deformylase activity
DC74_RS26395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DC74_RS26400	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DC74_RS26430	COG2188	Transcriptional regulator
DC74_RS26435	COG2182	Extracellular solute-binding protein
DC74_RS26440	COG1175	transmembrane transport
DC74_RS26445	COG0395	ABC-type sugar transport system, permease component
DC74_RS26450	COG1472	Belongs to the glycosyl hydrolase 3 family
DC74_RS26455	COG0363	glucosamine-6-phosphate deaminase activity
DC74_RS26460	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS26465	COG1309	transcriptional regulator
DC74_RS26480	COG1597	lipid kinase activity
DC74_RS26515	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DC74_RS26530	COG2066	Belongs to the glutaminase family
DC74_RS26545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DC74_RS26560	COG0477	Major facilitator Superfamily
DC74_RS26565	COG0598	Magnesium transport protein CorA
DC74_RS26570	COG2807	transmembrane transport
DC74_RS26575	COG2186	Transcriptional regulator
DC74_RS26580	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DC74_RS26585	COG1993	acr, cog1993
DC74_RS26590	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DC74_RS26620	COG4106	trans-aconitate 2-methyltransferase activity
DC74_RS26625	COG1126	abc transporter atp-binding protein
DC74_RS26630	COG0765	amino acid transport
DC74_RS26635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DC74_RS26640	COG0281	malic enzyme
DC74_RS26645	COG0604	alcohol dehydrogenase
DC74_RS26685	COG2205	protein histidine kinase activity
DC74_RS26690	COG0745	RESPONSE REGULATOR receiver
DC74_RS26705	COG1357	PFAM Pentapeptide repeats (8 copies)
DC74_RS26710	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DC74_RS26790	COG2267	carboxylic ester hydrolase activity
DC74_RS26800	COG1119	ATPase activity
DC74_RS26810	COG0768	penicillin binding
DC74_RS26820	COG2124	cytochrome p450
DC74_RS26840	COG0018	arginyl-trna synthetase
DC74_RS26845	COG0019	diaminopimelate decarboxylase activity
DC74_RS26850	COG0460	homoserine dehydrogenase
DC74_RS26855	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DC74_RS26860	COG0083	homoserine kinase activity
DC74_RS26875	COG0254	rRNA binding
DC74_RS26880	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DC74_RS26885	COG2890	protein-(glutamine-N5) methyltransferase activity
DC74_RS26895	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DC74_RS26900	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DC74_RS26920	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DC74_RS26925	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DC74_RS26930	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DC74_RS26935	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DC74_RS26940	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DC74_RS26945	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DC74_RS26950	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DC74_RS26960	COG2124	cytochrome p450
DC74_RS26970	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS26970	COG3321	synthase
DC74_RS26970	COG0300	oxidoreductase activity
DC74_RS26970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DC74_RS26970	COG0318	PFAM AMP-dependent synthetase and ligase
DC74_RS26995	COG0300	oxidoreductase activity
DC74_RS26995	COG0318	PFAM AMP-dependent synthetase and ligase
DC74_RS26995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DC74_RS26995	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS26995	COG3321	synthase
DC74_RS27015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DC74_RS27015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DC74_RS27015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DC74_RS27015	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS27015	COG3321	synthase
DC74_RS27030	COG0534	Mate efflux family protein
DC74_RS27035	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DC74_RS27035	COG2070	2-Nitropropane dioxygenase
DC74_RS27040	COG2124	cytochrome p450
DC74_RS27045	COG2124	cytochrome p450
DC74_RS27060	COG3804	dihydrodipicolinate reductase
DC74_RS27070	COG4585	Histidine kinase
DC74_RS27085	COG1250	3-hydroxyacyl-CoA dehydrogenase
DC74_RS27100	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
DC74_RS27135	COG1131	(ABC) transporter
DC74_RS27155	COG0183	Belongs to the thiolase family
DC74_RS27215	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DC74_RS27215	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DC74_RS27225	COG0745	RESPONSE REGULATOR receiver
DC74_RS27230	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DC74_RS27235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DC74_RS27270	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DC74_RS27275	COG0857	belongs to the CobB CobQ family
DC74_RS27275	COG0280	phosphate acetyltransferase
DC74_RS27280	COG0205	6-phosphofructokinase activity
DC74_RS27285	COG1136	(ABC) transporter
DC74_RS27285	COG0577	efflux transmembrane transporter activity
DC74_RS27290	COG0577	efflux transmembrane transporter activity
DC74_RS27290	COG1136	(ABC) transporter
DC74_RS27300	COG4565	transcriptional regulatory protein
DC74_RS27305	COG3290	protein histidine kinase activity
DC74_RS27310	COG1301	dicarboxylic acid transport
DC74_RS27315	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DC74_RS27325	COG0366	Alpha amylase catalytic
DC74_RS27330	COG0366	Alpha amylase catalytic
DC74_RS27345	COG1132	(ABC) transporter
DC74_RS27350	COG1132	(ABC) transporter
DC74_RS27365	COG1376	ErfK ybiS ycfS ynhG family protein
DC74_RS27385	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DC74_RS27385	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DC74_RS27390	COG0785	Cytochrome C biogenesis protein
DC74_RS27400	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DC74_RS27410	COG0438	transferase activity, transferring glycosyl groups
DC74_RS27440	COG0671	phosphoesterase, PA-phosphatase related
DC74_RS27455	COG1760	l-serine dehydratase
DC74_RS27460	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DC74_RS27465	COG0509	glycine decarboxylation via glycine cleavage system
DC74_RS27470	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DC74_RS27495	COG0747	negative chemotaxis
DC74_RS27505	COG0444	Belongs to the ABC transporter superfamily
DC74_RS27510	COG4608	Belongs to the ABC transporter superfamily
DC74_RS27520	COG2860	membrane
DC74_RS27540	COG0482	sulfurtransferase activity
DC74_RS27550	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DC74_RS27560	COG4221	oxidoreductase activity
DC74_RS27580	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DC74_RS27590	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DC74_RS27595	COG0154	amidase activity
DC74_RS27605	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DC74_RS27615	COG0667	Aldo Keto reductase
DC74_RS27635	COG3511	phospholipase C
DC74_RS27640	COG2409	Drug exporters of the RND superfamily
DC74_RS27665	COG2133	pyrroloquinoline quinone binding
DC74_RS27670	COG0667	Aldo Keto reductase
DC74_RS27680	COG5001	Diguanylate cyclase
DC74_RS27680	COG3300	MHYT domain
DC74_RS27690	COG0440	acetolactate synthase activity
DC74_RS27695	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DC74_RS27700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DC74_RS27725	COG0506	proline dehydrogenase activity
DC74_RS27730	COG1012	belongs to the aldehyde dehydrogenase family
DC74_RS27740	COG0473	3-isopropylmalate dehydrogenase activity
DC74_RS27745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DC74_RS27755	COG0831	urea catabolic process
DC74_RS27755	COG0832	Belongs to the urease beta subunit family
DC74_RS27760	COG0804	urea catabolic process
DC74_RS27765	COG2957	Belongs to the agmatine deiminase family
DC74_RS27770	COG1309	transcriptional regulator
DC74_RS27775	COG0477	Major facilitator Superfamily
DC74_RS27780	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DC74_RS27795	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DC74_RS27805	COG2814	Major facilitator Superfamily
DC74_RS27810	COG2376	Dihydroxyacetone kinase
DC74_RS27825	COG2018	Roadblock/LC7 domain
DC74_RS27845	COG2018	Roadblock/LC7 domain
DC74_RS27860	COG0179	Fumarylacetoacetate (FAA) hydrolase
DC74_RS27865	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DC74_RS27900	COG1414	Transcriptional regulator
DC74_RS27905	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DC74_RS27910	COG0066	3-isopropylmalate dehydratase activity
DC74_RS27920	COG0776	regulation of translation
DC74_RS27930	COG1920	GTP binding
DC74_RS27940	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DC74_RS27945	COG1181	Belongs to the D-alanine--D-alanine ligase family
DC74_RS27965	COG0351	phosphomethylpyrimidine kinase
DC74_RS27970	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DC74_RS27975	COG1461	Dihydroxyacetone kinase
DC74_RS27985	COG0742	ribosomal rna small subunit methyltransferase
DC74_RS27990	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DC74_RS28005	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DC74_RS28010	COG0571	ribonuclease III activity
DC74_RS28015	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DC74_RS28025	COG1254	Belongs to the acylphosphatase family
DC74_RS28040	COG0477	Major facilitator Superfamily
DC74_RS28055	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DC74_RS28090	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DC74_RS28110	COG0228	four-way junction DNA binding
DC74_RS28115	COG1837	Belongs to the UPF0109 family
DC74_RS28120	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DC74_RS28125	COG0336	Belongs to the RNA methyltransferase TrmD family
DC74_RS28130	COG0335	large ribosomal subunit rRNA binding
DC74_RS28145	COG0681	Belongs to the peptidase S26 family
DC74_RS28150	COG0681	Belongs to the peptidase S26 family
DC74_RS28165	COG0792	nuclease activity
DC74_RS28180	COG1191	sigma factor activity
DC74_RS28190	COG0052	Belongs to the universal ribosomal protein uS2 family
DC74_RS28195	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DC74_RS28200	COG0528	UMP kinase activity
DC74_RS28205	COG0233	cytoplasmic translational termination
DC74_RS28215	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DC74_RS28225	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DC74_RS28230	COG3842	ATPase activity
DC74_RS28235	COG2197	response regulator
DC74_RS28240	COG4585	Histidine kinase
DC74_RS28275	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DC74_RS28285	COG1012	belongs to the aldehyde dehydrogenase family
DC74_RS28300	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DC74_RS28310	COG1012	belongs to the aldehyde dehydrogenase family
DC74_RS28320	COG3842	ATPase activity
DC74_RS28325	COG1176	ABC-type spermidine putrescine transport system, permease component I
DC74_RS28330	COG1177	transmembrane transport
DC74_RS28335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DC74_RS28365	COG2508	Transcriptional regulator
DC74_RS28370	COG1012	belongs to the aldehyde dehydrogenase family
DC74_RS28380	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DC74_RS28385	COG0750	zinc metalloprotease
DC74_RS28390	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DC74_RS28405	COG0442	prolyl-tRNA aminoacylation
DC74_RS28410	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
DC74_RS28420	COG0779	Required for maturation of 30S ribosomal subunits
DC74_RS28435	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DC74_RS28445	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DC74_RS28450	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DC74_RS28465	COG0455	bacterial-type flagellum organization
DC74_RS28480	COG3266	domain, Protein
DC74_RS28510	COG1404	Belongs to the peptidase S8 family
DC74_RS28560	COG1674	ftsk spoiiie
DC74_RS28570	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DC74_RS28575	COG1185	polyribonucleotide nucleotidyltransferase activity
DC74_RS28580	COG0612	Peptidase, M16
DC74_RS28585	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DC74_RS28605	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DC74_RS28610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DC74_RS28615	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DC74_RS28645	COG2770	Histidine kinase
DC74_RS28645	COG2208	phosphoserine phosphatase activity
DC74_RS28650	COG3850	Histidine kinase
DC74_RS28650	COG2205	protein histidine kinase activity
DC74_RS28650	COG4999	Histidine kinase
DC74_RS28650	COG3437	response regulator, receiver
DC74_RS28670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DC74_RS28680	COG1058	Belongs to the CinA family
DC74_RS28680	COG1546	Belongs to the CinA family
DC74_RS28685	COG1396	sequence-specific DNA binding
DC74_RS28690	COG0783	Belongs to the Dps family
DC74_RS28700	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DC74_RS28750	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DC74_RS28755	COG0640	Transcriptional regulator
DC74_RS28760	COG1316	TRANSCRIPTIONal
DC74_RS28775	COG0628	permease
DC74_RS28790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DC74_RS28805	COG0765	amino acid transport
DC74_RS28810	COG0765	amino acid transport
DC74_RS28815	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DC74_RS28820	COG1126	abc transporter atp-binding protein
DC74_RS28830	COG2205	protein histidine kinase activity
DC74_RS28840	COG0583	DNA-binding transcription factor activity
DC74_RS28850	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DC74_RS28865	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DC74_RS28875	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DC74_RS28880	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DC74_RS28890	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DC74_RS28925	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DC74_RS28930	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DC74_RS28935	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DC74_RS28965	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DC74_RS29000	COG2186	Transcriptional regulator
DC74_RS29005	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DC74_RS29020	COG0187	DNA topoisomerase II activity
DC74_RS29030	COG4585	Histidine kinase
DC74_RS29035	COG2197	response regulator
DC74_RS29050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DC74_RS29055	COG0612	Peptidase, M16
DC74_RS29065	COG0739	heme binding
DC74_RS29075	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DC74_RS29080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DC74_RS29080	COG0045	succinate-CoA ligase (ADP-forming) activity
DC74_RS29080	COG1042	CoA-binding domain protein
DC74_RS29095	COG1435	thymidine kinase activity
DC74_RS29130	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DC74_RS29135	COG0483	inositol monophosphate 1-phosphatase activity
DC74_RS29140	COG0745	RESPONSE REGULATOR receiver
DC74_RS29145	COG2205	protein histidine kinase activity
DC74_RS29170	COG0756	dUTP diphosphatase activity
DC74_RS29185	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DC74_RS29190	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DC74_RS29195	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DC74_RS29235	COG0569	domain protein
DC74_RS29245	COG0531	amino acid
DC74_RS29250	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DC74_RS29275	COG3424	synthase
DC74_RS29305	COG1799	cell septum assembly
DC74_RS29335	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DC74_RS29340	COG2235	arginine
DC74_RS29345	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DC74_RS29350	COG0531	amino acid
DC74_RS29355	COG1024	Enoyl-CoA hydratase
DC74_RS29385	COG0546	phosphoglycolate phosphatase activity
DC74_RS29400	COG1960	acyl-CoA dehydrogenase activity
DC74_RS29410	COG1960	acyl-CoA dehydrogenase activity
DC74_RS29415	COG1024	Enoyl-CoA hydratase
DC74_RS29430	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DC74_RS29450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DC74_RS29460	COG2175	clavaminate synthase activity
DC74_RS29465	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS29515	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DC74_RS29520	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DC74_RS29535	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DC74_RS29540	COG0318	PFAM AMP-dependent synthetase and ligase
DC74_RS29585	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
DC74_RS29670	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DC74_RS29690	COG0137	argininosuccinate synthase activity
DC74_RS29695	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DC74_RS29715	COG1653	transport
DC74_RS29720	COG1175	transmembrane transport
DC74_RS29725	COG0395	ABC-type sugar transport system, permease component
DC74_RS29730	COG1940	carbohydrate kinase activity
DC74_RS29735	COG4213	ABC transporter substrate-binding protein
DC74_RS29745	COG4214	carbohydrate transport
DC74_RS29750	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DC74_RS29755	COG0531	amino acid
DC74_RS29765	COG1250	3-hydroxyacyl-CoA dehydrogenase
DC74_RS29765	COG1024	Enoyl-CoA hydratase
DC74_RS29770	COG0183	Belongs to the thiolase family
DC74_RS29775	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DC74_RS29790	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DC74_RS29795	COG0446	pyridine nucleotide-disulphide oxidoreductase
DC74_RS29805	COG0183	Belongs to the thiolase family
DC74_RS29815	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DC74_RS29820	COG3253	May function as heme-dependent peroxidase
DC74_RS29850	COG4152	abc transporter atp-binding protein
DC74_RS29885	COG1136	(ABC) transporter
DC74_RS29885	COG0577	efflux transmembrane transporter activity
DC74_RS29895	COG4585	Histidine kinase
DC74_RS29900	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DC74_RS29905	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DC74_RS29920	COG0741	lytic transglycosylase activity
DC74_RS29920	COG1196	nuclear chromosome segregation
DC74_RS29920	COG0739	heme binding
DC74_RS29935	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DC74_RS29945	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DC74_RS29950	COG0693	protein deglycase activity
DC74_RS29955	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
DC74_RS30125	COG1518	maintenance of DNA repeat elements
DC74_RS30130	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
DC74_RS30215	COG1302	Protein conserved in bacteria
DC74_RS30245	COG0009	L-threonylcarbamoyladenylate synthase
DC74_RS30250	COG0288	reversible hydration of carbon dioxide
DC74_RS30325	COG2801	Transposase and inactivated derivatives
DC74_RS30375	COG0159	tryptophan synthase activity
DC74_RS30450	COG0714	Associated with various cellular activities
DC74_RS30485	COG1475	DNA binding
DC74_RS30585	COG1181	Belongs to the D-alanine--D-alanine ligase family
DC74_RS30635	COG0641	radical SAM
DC74_RS30780	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DC74_RS30825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DC74_RS30830	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DC74_RS30850	COG0529	Catalyzes the synthesis of activated sulfate
DC74_RS30855	COG0175	sulfate reduction
DC74_RS30860	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DC74_RS30885	COG1960	acyl-CoA dehydrogenase activity
DC74_RS30900	COG3485	protocatechuate 3,4-dioxygenase
DC74_RS30950	COG2080	2 iron, 2 sulfur cluster binding
DC74_RS30955	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DC74_RS30960	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DC74_RS30970	COG3511	phospholipase C
DC74_RS30975	COG0667	Aldo Keto reductase
DC74_RS30985	COG1376	ErfK ybiS ycfS ynhG family protein
DC74_RS31010	COG0842	Transport permease protein
DC74_RS31010	COG1131	(ABC) transporter
DC74_RS31010	COG1716	ATPase activity
DC74_RS31015	COG2233	PERMEase
DC74_RS31060	COG3290	protein histidine kinase activity
DC74_RS31065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DC74_RS31065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DC74_RS31070	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DC74_RS31085	COG0640	Transcriptional regulator
DC74_RS31090	COG0789	Transcriptional regulator
DC74_RS31095	COG0789	Transcriptional regulator
DC74_RS31100	COG1162	GTPase activity
DC74_RS31115	COG0028	Belongs to the TPP enzyme family
DC74_RS31135	COG1802	Transcriptional regulator
DC74_RS31150	COG3835	regulator
DC74_RS31165	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DC74_RS31195	COG4552	Acetyltransferase involved in intracellular survival and related
DC74_RS31210	COG0318	PFAM AMP-dependent synthetase and ligase
DC74_RS31285	COG0318	PFAM AMP-dependent synthetase and ligase
DC74_RS31295	COG2315	Protein conserved in bacteria
DC74_RS31310	COG0753	catalase activity
DC74_RS31315	COG0028	Belongs to the TPP enzyme family
DC74_RS31320	COG2084	Dehydrogenase
DC74_RS31325	COG3622	Belongs to the hyi family
DC74_RS31345	COG2351	hydroxyisourate hydrolase activity
DC74_RS31355	COG2233	PERMEase
DC74_RS31365	COG2233	PERMEase
DC74_RS31385	COG1288	antiporter activity
DC74_RS31395	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DC74_RS31415	COG1414	Transcriptional regulator
DC74_RS31425	COG1953	Uracil, thiamine, allantoin
DC74_RS31430	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DC74_RS31435	COG4266	Belongs to the allantoicase family
DC74_RS31465	COG0800	Aldolase
DC74_RS31475	COG0583	DNA-binding transcription factor activity
DC74_RS31490	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS31495	COG2188	Transcriptional regulator
DC74_RS31505	COG1172	Belongs to the binding-protein-dependent transport system permease family
DC74_RS31515	COG1940	carbohydrate kinase activity
DC74_RS31525	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DC74_RS31570	COG0435	Glutathione S-transferase
DC74_RS31585	COG2409	Drug exporters of the RND superfamily
DC74_RS31590	COG0387	Pfam Sodium calcium exchanger
DC74_RS31600	COG0405	Gamma-glutamyltransferase
DC74_RS31610	COG1335	isochorismatase
DC74_RS31615	COG0477	Major facilitator Superfamily
DC74_RS31630	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DC74_RS31650	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DC74_RS31655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DC74_RS31675	COG0095	Lipoate-protein ligase
DC74_RS31680	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DC74_RS31695	COG0483	inositol monophosphate 1-phosphatase activity
DC74_RS31705	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DC74_RS31720	COG1309	transcriptional regulator
DC74_RS31735	COG0494	nUDIX hydrolase
DC74_RS31740	COG1929	Belongs to the glycerate kinase type-1 family
DC74_RS31750	COG0688	phosphatidylethanolamine metabolic process
DC74_RS31755	COG1960	acyl-CoA dehydrogenase activity
DC74_RS31765	COG2301	Belongs to the HpcH HpaI aldolase family
DC74_RS31770	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DC74_RS31770	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DC74_RS31785	COG1250	3-hydroxyacyl-CoA dehydrogenase
DC74_RS31805	COG0789	Transcriptional regulator
DC74_RS31835	COG0366	Alpha amylase catalytic
DC74_RS31845	COG2362	D-Aminopeptidase
DC74_RS31850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DC74_RS31865	COG2124	cytochrome p450
DC74_RS31880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DC74_RS31900	COG0010	Belongs to the arginase family
DC74_RS31905	COG0457	Tetratricopeptide repeat
DC74_RS31925	COG1597	lipid kinase activity
DC74_RS31975	COG2154	pterin-4-alpha-carbinolamine dehydratase
DC74_RS31995	COG2890	protein-(glutamine-N5) methyltransferase activity
DC74_RS32020	COG0656	L-ascorbic acid biosynthetic process
DC74_RS32030	COG0583	DNA-binding transcription factor activity
DC74_RS32055	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DC74_RS32065	COG1605	Chorismate mutase
DC74_RS32065	COG0287	Prephenate dehydrogenase
DC74_RS32085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DC74_RS32095	COG1012	belongs to the aldehyde dehydrogenase family
DC74_RS32135	COG1132	(ABC) transporter
DC74_RS32165	COG2197	response regulator
DC74_RS32185	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DC74_RS32220	COG1136	(ABC) transporter
DC74_RS32220	COG0577	efflux transmembrane transporter activity
DC74_RS32225	COG0577	efflux transmembrane transporter activity
DC74_RS32225	COG1136	(ABC) transporter
DC74_RS32240	COG0745	RESPONSE REGULATOR receiver
DC74_RS32245	COG2205	protein histidine kinase activity
DC74_RS32260	COG0702	epimerase
DC74_RS32265	COG0477	Major facilitator Superfamily
DC74_RS32275	COG0745	RESPONSE REGULATOR receiver
DC74_RS32300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DC74_RS32325	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS32330	COG0477	Major facilitator Superfamily
DC74_RS32340	COG0431	NADPH-dependent FMN reductase
DC74_RS32345	COG0667	Aldo Keto reductase
DC74_RS32395	COG2124	cytochrome p450
DC74_RS32400	COG1819	glycosyl
DC74_RS32410	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
DC74_RS32435	COG2192	nodulation
DC74_RS32465	COG5002	protein histidine kinase activity
DC74_RS32480	COG0697	spore germination
DC74_RS32505	COG1522	sequence-specific DNA binding
DC74_RS32525	COG1063	alcohol dehydrogenase
DC74_RS32540	COG4585	Histidine kinase
DC74_RS32545	COG2197	response regulator
DC74_RS32550	COG2340	Cysteine-rich secretory protein family
DC74_RS32560	COG0640	Transcriptional regulator
DC74_RS32580	COG3903	Transcriptional regulator
DC74_RS32580	COG3629	intracellular signal transduction
DC74_RS32585	COG0720	synthase
DC74_RS32595	COG0302	gtp cyclohydrolase
DC74_RS32600	COG0516	GMP reductase activity
DC74_RS32600	COG0517	IMP dehydrogenase activity
DC74_RS32605	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DC74_RS32610	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DC74_RS32625	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DC74_RS32645	COG0647	UMP catabolic process
DC74_RS32680	COG0717	Belongs to the dCTP deaminase family
DC74_RS32685	COG0475	glutathione-regulated potassium exporter activity
DC74_RS32695	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DC74_RS32700	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DC74_RS32710	COG1834	amidinotransferase
DC74_RS32735	COG0583	DNA-binding transcription factor activity
DC74_RS32740	COG1846	Transcriptional regulator
DC74_RS32760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DC74_RS32765	COG1846	Transcriptional regulator
DC74_RS32775	COG1309	transcriptional regulator
DC74_RS32800	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
DC74_RS32815	COG1012	belongs to the aldehyde dehydrogenase family
DC74_RS32830	COG1136	(ABC) transporter
DC74_RS32890	COG2205	protein histidine kinase activity
DC74_RS32895	COG0745	RESPONSE REGULATOR receiver
DC74_RS32920	COG3226	Transcriptional regulator
DC74_RS32930	COG1846	Transcriptional regulator
DC74_RS32940	COG1309	transcriptional regulator
DC74_RS32950	COG1309	transcriptional regulator
DC74_RS32955	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS32960	COG1349	DNA-binding transcription factor activity
DC74_RS32970	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DC74_RS32975	COG2814	Major facilitator Superfamily
DC74_RS32985	COG1515	deoxyribonuclease V activity
DC74_RS32990	COG3268	Saccharopine dehydrogenase
DC74_RS33000	COG1285	pathogenesis
DC74_RS33005	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DC74_RS33015	COG1960	acyl-CoA dehydrogenase activity
DC74_RS33020	COG0183	Belongs to the thiolase family
DC74_RS33025	COG1250	3-hydroxyacyl-CoA dehydrogenase
DC74_RS33025	COG1024	Enoyl-CoA hydratase
DC74_RS33040	COG1113	amino acid transport
DC74_RS33050	COG3568	Endonuclease Exonuclease Phosphatase
DC74_RS33100	COG2936	dipeptidyl-peptidase activity
DC74_RS33125	COG2183	response to ionizing radiation
DC74_RS33135	COG4977	sequence-specific DNA binding
DC74_RS33170	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DC74_RS33205	COG1134	teichoic acid transport
DC74_RS33210	COG1562	ergosterol biosynthetic process
DC74_RS33220	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DC74_RS33230	COG1657	PFAM Prenyltransferase squalene oxidase
DC74_RS33250	COG2365	Tyrosine phosphatase family
DC74_RS33255	COG2755	lipolytic protein G-D-S-L family
DC74_RS33315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DC74_RS33340	COG2018	Roadblock/LC7 domain
DC74_RS33365	COG1228	amidohydrolase
DC74_RS33370	COG2267	carboxylic ester hydrolase activity
DC74_RS33400	COG2124	cytochrome p450
DC74_RS33405	COG1686	Belongs to the peptidase S11 family
DC74_RS33460	COG3246	L-lysine catabolic process to acetate
DC74_RS33475	COG0174	glutamine synthetase
DC74_RS33485	COG0477	Major facilitator Superfamily
DC74_RS33490	COG1012	belongs to the aldehyde dehydrogenase family
DC74_RS33515	COG1024	Enoyl-CoA hydratase
DC74_RS33520	COG1960	acyl-CoA dehydrogenase activity
DC74_RS33530	COG1652	LysM domain
DC74_RS33535	COG1113	amino acid transport
DC74_RS33540	COG2706	6-phosphogluconolactonase activity
DC74_RS33575	COG0698	ribose 5-phosphate isomerase
DC74_RS33580	COG0149	triose-phosphate isomerase activity
DC74_RS33635	COG3537	Alpha-1,2-mannosidase
DC74_RS33650	COG0531	amino acid
DC74_RS33655	COG3360	Dodecin
DC74_RS33705	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
DC74_RS33710	COG0121	glutamine amidotransferase
DC74_RS33715	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DC74_RS33720	COG3572	ergothioneine biosynthetic process
DC74_RS33755	COG1960	acyl-CoA dehydrogenase activity
DC74_RS33760	COG1960	acyl-CoA dehydrogenase activity
DC74_RS33790	COG0601	transmembrane transport
DC74_RS33795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DC74_RS33800	COG0444	Belongs to the ABC transporter superfamily
DC74_RS33815	COG1349	DNA-binding transcription factor activity
DC74_RS33820	COG2814	Major facilitator Superfamily
DC74_RS33830	COG1070	Carbohydrate kinase
DC74_RS33835	COG0588	phosphoglycerate mutase activity
DC74_RS33840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DC74_RS33845	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DC74_RS33845	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DC74_RS33870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DC74_RS33870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DC74_RS33875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DC74_RS33880	COG1070	Carbohydrate kinase
DC74_RS33885	COG3458	cephalosporin-C deacetylase activity
DC74_RS33900	COG0765	amino acid transport
DC74_RS33910	COG2040	homocysteine
DC74_RS33925	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DC74_RS33970	COG2018	Roadblock/LC7 domain
DC74_RS33990	COG1946	Acyl-CoA thioesterase
DC74_RS34005	COG1132	(ABC) transporter
DC74_RS34020	COG1301	dicarboxylic acid transport
DC74_RS34045	COG1132	(ABC) transporter
DC74_RS34055	COG1556	Lactate utilization protein
DC74_RS34060	COG1139	Iron-sulfur cluster binding protein
DC74_RS34065	COG0247	lactate metabolic process
DC74_RS34070	COG0477	Major facilitator Superfamily
DC74_RS34095	COG1116	anion transmembrane transporter activity
DC74_RS34100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DC74_RS34105	COG0432	Pfam Uncharacterised protein family UPF0047
DC74_RS34110	COG2124	cytochrome p450
DC74_RS34125	COG2304	oxidoreductase activity
DC74_RS34145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DC74_RS34150	COG3467	pyridoxamine 5'-phosphate
DC74_RS34175	COG1309	transcriptional regulator
DC74_RS34200	COG2124	cytochrome p450
DC74_RS34205	COG1309	transcriptional regulator
DC74_RS34245	COG4213	ABC transporter substrate-binding protein
DC74_RS34285	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DC74_RS34290	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DC74_RS34310	COG1595	DNA-templated transcription, initiation
DC74_RS34320	COG2706	6-phosphogluconolactonase activity
DC74_RS34345	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DC74_RS34355	COG1902	pentaerythritol trinitrate reductase activity
DC74_RS34385	COG2197	response regulator
DC74_RS34390	COG0366	Alpha amylase catalytic
DC74_RS34395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DC74_RS34410	COG2345	Transcriptional regulator
DC74_RS34430	COG0438	transferase activity, transferring glycosyl groups
DC74_RS34440	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DC74_RS34455	COG1285	pathogenesis
DC74_RS34495	COG0477	Major facilitator Superfamily
DC74_RS34500	COG1957	nucleoside hydrolase
DC74_RS34505	COG1609	Transcriptional regulator
DC74_RS34525	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
DC74_RS34545	COG1796	DNA polymerase
DC74_RS34545	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DC74_RS34570	COG0488	(ABC) transporter
DC74_RS34575	COG0488	(ABC) transporter
DC74_RS34590	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DC74_RS34600	COG2197	response regulator
DC74_RS34605	COG4585	Histidine kinase
DC74_RS34615	COG0596	Alpha beta hydrolase
DC74_RS34620	COG0805	protein transport
DC74_RS34690	COG2205	protein histidine kinase activity
DC74_RS34695	COG0745	RESPONSE REGULATOR receiver
DC74_RS34705	COG3291	Pkd domain containing protein
DC74_RS34705	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DC74_RS34755	COG1012	belongs to the aldehyde dehydrogenase family
DC74_RS34775	COG1309	transcriptional regulator
DC74_RS34785	COG1960	acyl-CoA dehydrogenase activity
DC74_RS34790	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DC74_RS34815	COG1228	amidohydrolase
DC74_RS34825	COG0463	Glycosyl transferase, family 2
DC74_RS34840	COG2270	Major facilitator Superfamily
DC74_RS34870	COG3012	SEC-C Motif Domain Protein
DC74_RS34880	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DC74_RS34885	COG1793	dna ligase
DC74_RS34885	COG3285	dna ligase
DC74_RS34890	COG1686	Belongs to the peptidase S11 family
DC74_RS34895	COG1278	Cold shock
DC74_RS34930	COG0395	ABC-type sugar transport system, permease component
DC74_RS34935	COG1175	transmembrane transport
DC74_RS34945	COG1609	Transcriptional regulator
DC74_RS34960	COG4585	Histidine kinase
DC74_RS34965	COG2197	response regulator
DC74_RS34970	COG0739	heme binding
DC74_RS35000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DC74_RS35010	COG1846	Transcriptional regulator
DC74_RS35015	COG1764	response to oxidative stress
DC74_RS35055	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DC74_RS35125	COG2124	cytochrome p450
DC74_RS35130	COG1024	Enoyl-CoA hydratase
DC74_RS35130	COG1250	3-hydroxyacyl-CoA dehydrogenase
DC74_RS35140	COG0110	maltose O-acetyltransferase activity
DC74_RS35155	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DC74_RS35165	COG1832	CoA-binding protein
DC74_RS35180	COG1739	Uncharacterized protein family UPF0029
DC74_RS35185	COG0531	amino acid
DC74_RS35195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DC74_RS35230	COG0584	glycerophosphoryl diester phosphodiesterase
DC74_RS35235	COG0420	3'-5' exonuclease activity
DC74_RS35240	COG0419	ATPase involved in DNA repair
DC74_RS35245	COG1522	sequence-specific DNA binding
DC74_RS35265	COG0346	lactoylglutathione lyase activity
DC74_RS35275	COG2188	Transcriptional regulator
DC74_RS35280	COG1940	carbohydrate kinase activity
DC74_RS35295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DC74_RS35300	COG3415	Transposase
DC74_RS35300	COG2801	Transposase and inactivated derivatives
DC74_RS35310	COG1309	transcriptional regulator
DC74_RS35330	COG0456	acetyltransferase
DC74_RS35345	COG1012	belongs to the aldehyde dehydrogenase family
DC74_RS35365	COG1802	Transcriptional regulator
DC74_RS35375	COG0583	DNA-binding transcription factor activity
DC74_RS35395	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DC74_RS35400	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DC74_RS35425	COG0740	serine-type endopeptidase activity
DC74_RS35455	COG0038	chloride channel
DC74_RS35490	COG1136	(ABC) transporter
DC74_RS35605	COG0831	urea catabolic process
DC74_RS35610	COG0832	Belongs to the urease beta subunit family
DC74_RS35615	COG0804	urea catabolic process
DC74_RS35625	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DC74_RS35630	COG0829	nickel cation binding
DC74_RS35675	COG0205	6-phosphofructokinase activity
DC74_RS35680	COG3442	glutamine amidotransferase
DC74_RS35690	COG0242	peptide deformylase activity
DC74_RS35700	COG1960	acyl-CoA dehydrogenase activity
DC74_RS35750	COG1215	transferase activity, transferring glycosyl groups
DC74_RS35760	COG0745	RESPONSE REGULATOR receiver
DC74_RS35765	COG2205	protein histidine kinase activity
DC74_RS35770	COG3960	tartronate-semialdehyde synthase activity
DC74_RS35775	COG3622	Belongs to the hyi family
DC74_RS35780	COG2084	Dehydrogenase
DC74_RS35785	COG2205	protein histidine kinase activity
DC74_RS35795	COG2124	cytochrome p450
DC74_RS35815	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS35830	COG0477	Major facilitator Superfamily
DC74_RS35845	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
DC74_RS35875	COG0375	protein maturation
DC74_RS35880	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DC74_RS35890	COG0298	carbon dioxide binding
DC74_RS35900	COG0309	Hydrogenase expression formation protein (HypE)
DC74_RS35925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DC74_RS35935	COG2837	iron assimilation
DC74_RS35950	COG0640	Transcriptional regulator
DC74_RS35955	COG0531	amino acid
DC74_RS35970	COG1793	dna ligase
DC74_RS35985	COG0318	PFAM AMP-dependent synthetase and ligase
DC74_RS36005	COG3290	protein histidine kinase activity
DC74_RS36010	COG1349	DNA-binding transcription factor activity
DC74_RS36015	COG3395	kinase activity
DC74_RS36020	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DC74_RS36130	COG1518	maintenance of DNA repeat elements
DC74_RS36145	COG0242	peptide deformylase activity
DC74_RS36205	COG3293	Transposase
DC74_RS36210	COG2814	Major facilitator Superfamily
DC74_RS36230	COG3118	belongs to the thioredoxin family
DC74_RS36260	COG2233	PERMEase
DC74_RS36295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DC74_RS36310	COG0318	PFAM AMP-dependent synthetase and ligase
DC74_RS36315	COG1960	acyl-CoA dehydrogenase activity
DC74_RS36320	COG1960	acyl-CoA dehydrogenase activity
DC74_RS36325	COG1960	acyl-CoA dehydrogenase activity
DC74_RS36330	COG1024	Enoyl-CoA hydratase
DC74_RS36335	COG1960	acyl-CoA dehydrogenase activity
DC74_RS36345	COG1309	transcriptional regulator
DC74_RS36350	COG0183	Belongs to the thiolase family
DC74_RS36355	COG2365	Tyrosine phosphatase family
DC74_RS36375	COG1024	Enoyl-CoA hydratase
DC74_RS36385	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS36390	COG3971	2-oxopent-4-enoate hydratase activity
DC74_RS36425	COG1960	acyl-CoA dehydrogenase activity
DC74_RS36430	COG2267	carboxylic ester hydrolase activity
DC74_RS36440	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DC74_RS36445	COG2030	dehydratase
DC74_RS36450	COG1053	succinate dehydrogenase
DC74_RS36465	COG2945	thiolester hydrolase activity
DC74_RS36465	COG0596	Alpha beta hydrolase
DC74_RS36480	COG3511	phospholipase C
DC74_RS36490	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DC74_RS36515	COG1181	Belongs to the D-alanine--D-alanine ligase family
DC74_RS36520	COG0477	Major facilitator Superfamily
DC74_RS36550	COG1509	lysine 2,3-aminomutase activity
DC74_RS36555	COG0436	Aminotransferase
DC74_RS36570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DC74_RS36625	COG2261	transglycosylase associated protein
DC74_RS36645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DC74_RS36655	COG1316	TRANSCRIPTIONal
DC74_RS36665	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DC74_RS36670	COG0640	Transcriptional regulator
DC74_RS36720	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DC74_RS36725	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DC74_RS36745	COG2837	iron assimilation
DC74_RS36770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DC74_RS36775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DC74_RS36780	COG1116	anion transmembrane transporter activity
DC74_RS36785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DC74_RS36795	COG0596	Alpha beta hydrolase
DC74_RS36810	COG0596	Alpha beta hydrolase
DC74_RS36825	COG2124	cytochrome p450
DC74_RS36880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DC74_RS36885	COG1120	ATPase activity
DC74_RS36900	COG1120	ATPase activity
DC74_RS36915	COG0515	serine threonine protein kinase
DC74_RS36925	COG1132	(ABC) transporter
DC74_RS36930	COG1132	(ABC) transporter
DC74_RS36935	COG2197	response regulator
DC74_RS36975	COG0583	DNA-binding transcription factor activity
DC74_RS36995	COG1595	DNA-templated transcription, initiation
DC74_RS37045	COG0167	dihydroorotate dehydrogenase activity
DC74_RS37055	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DC74_RS37060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DC74_RS37075	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DC74_RS37085	COG1021	2,3-dihydroxybenzoate-AMP ligase
DC74_RS37090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DC74_RS37105	COG0488	(ABC) transporter
DC74_RS37120	COG1309	transcriptional regulator
DC74_RS37125	COG0154	amidase activity
DC74_RS37130	COG3321	synthase
DC74_RS37130	COG0604	alcohol dehydrogenase
DC74_RS37130	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS37140	COG1132	(ABC) transporter
DC74_RS37155	COG3226	Transcriptional regulator
DC74_RS37160	COG0154	amidase activity
DC74_RS37170	COG1733	regulation of RNA biosynthetic process
DC74_RS37190	COG0477	Major facilitator Superfamily
DC74_RS37220	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
DC74_RS37235	COG1309	transcriptional regulator
DC74_RS37245	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DC74_RS37255	COG0646	methionine synthase
DC74_RS37255	COG1410	methionine synthase
DC74_RS37260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DC74_RS37265	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DC74_RS37270	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS37280	COG2197	response regulator
DC74_RS37285	COG0066	3-isopropylmalate dehydratase activity
DC74_RS37290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DC74_RS37295	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DC74_RS37300	COG0473	3-isopropylmalate dehydrogenase activity
DC74_RS37305	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DC74_RS37330	COG0477	Major facilitator Superfamily
DC74_RS37345	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DC74_RS37350	COG1692	metallophosphoesterase
DC74_RS37355	COG0475	glutathione-regulated potassium exporter activity
DC74_RS37360	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS37365	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DC74_RS37370	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DC74_RS37375	COG0129	dihydroxy-acid dehydratase activity
DC74_RS37405	COG3903	Transcriptional regulator
DC74_RS37405	COG3629	intracellular signal transduction
DC74_RS37430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DC74_RS37440	COG2267	carboxylic ester hydrolase activity
DC74_RS37450	COG1063	alcohol dehydrogenase
DC74_RS37490	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS37515	COG3634	alkyl hydroperoxide reductase activity
DC74_RS37525	COG0702	epimerase
DC74_RS37535	COG2318	DinB family
DC74_RS37545	COG2045	Belongs to the ComB family
DC74_RS37560	COG1960	acyl-CoA dehydrogenase activity
DC74_RS37570	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DC74_RS37575	COG0583	DNA-binding transcription factor activity
DC74_RS37600	COG2268	Band 7 protein
DC74_RS37605	COG1585	Membrane protein implicated in regulation of membrane protease activity
DC74_RS37615	COG0672	)-iron permease
DC74_RS37700	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DC74_RS37715	COG2249	NAD(P)H dehydrogenase (quinone) activity
DC74_RS37720	COG0640	Transcriptional regulator
DC74_RS37730	COG2197	response regulator
DC74_RS37735	COG4585	Histidine kinase
DC74_RS37745	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DC74_RS37750	COG0443	Heat shock 70 kDa protein
DC74_RS37785	COG0517	IMP dehydrogenase activity
DC74_RS37785	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DC74_RS37815	COG0640	Transcriptional regulator
DC74_RS37820	COG0463	Glycosyl transferase, family 2
DC74_RS37825	COG0488	(ABC) transporter
DC74_RS37845	COG0367	asparagine synthase
DC74_RS37855	COG2423	ornithine cyclodeaminase activity
DC74_RS37860	COG3469	chitinase activity
DC74_RS37870	COG0009	L-threonylcarbamoyladenylate synthase
DC74_RS37890	COG2378	regulation of single-species biofilm formation
DC74_RS37895	COG1070	Carbohydrate kinase
DC74_RS37900	COG1063	alcohol dehydrogenase
DC74_RS37910	COG2124	cytochrome p450
DC74_RS37925	COG0702	epimerase
DC74_RS37935	COG1191	sigma factor activity
DC74_RS37995	COG2132	Multicopper oxidase
DC74_RS38015	COG2226	methyltransferase
DC74_RS38040	COG1175	transmembrane transport
DC74_RS38045	COG0395	ABC-type sugar transport system, permease component
DC74_RS38065	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DC74_RS38110	COG0477	Major facilitator Superfamily
DC74_RS38195	COG2205	protein histidine kinase activity
DC74_RS38265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DC74_RS38280	COG0747	negative chemotaxis
DC74_RS38300	COG1464	Belongs to the NlpA lipoprotein family
DC74_RS38310	COG2011	ABC-type metal ion transport system permease component
DC74_RS38335	COG0504	CTP synthase activity
DC74_RS38360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DC74_RS38375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DC74_RS38390	COG3046	protein related to deoxyribodipyrimidine photolyase
DC74_RS38400	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS38405	COG1556	Lactate utilization protein
DC74_RS38410	COG1139	Iron-sulfur cluster binding protein
DC74_RS38415	COG0247	lactate metabolic process
DC74_RS38430	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS38455	COG2957	Belongs to the agmatine deiminase family
DC74_RS38465	COG4608	Belongs to the ABC transporter superfamily
DC74_RS38470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DC74_RS38480	COG0747	negative chemotaxis
DC74_RS38485	COG2957	Belongs to the agmatine deiminase family
DC74_RS38490	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DC74_RS38490	COG0515	serine threonine protein kinase
DC74_RS38510	COG2957	Belongs to the agmatine deiminase family
DC74_RS38515	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DC74_RS38585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DC74_RS38590	COG0697	spore germination
DC74_RS38600	COG4257	antibiotic catabolic process
DC74_RS38630	COG3938	Belongs to the proline racemase family
DC74_RS38665	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DC74_RS38705	COG3321	synthase
DC74_RS38705	COG0604	alcohol dehydrogenase
DC74_RS38710	COG3321	synthase
DC74_RS38710	COG0604	alcohol dehydrogenase
DC74_RS38735	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DC74_RS38745	COG0604	alcohol dehydrogenase
DC74_RS38745	COG3321	synthase
DC74_RS38755	COG3321	synthase
DC74_RS38755	COG0604	alcohol dehydrogenase
DC74_RS38770	COG2197	response regulator
DC74_RS38795	COG1473	amidohydrolase
DC74_RS38810	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DC74_RS38825	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DC74_RS38840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DC74_RS38870	COG1012	belongs to the aldehyde dehydrogenase family
DC74_RS38875	COG1063	alcohol dehydrogenase
DC74_RS38880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DC74_RS38890	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DC74_RS38910	COG1140	nitrate reductase beta subunit
DC74_RS38975	COG4948	Mandelate Racemase Muconate Lactonizing
DC74_RS39050	COG2345	Transcriptional regulator
DC74_RS39065	COG0673	inositol 2-dehydrogenase activity
DC74_RS39125	COG0702	epimerase
DC74_RS39145	COG1132	(ABC) transporter
DC74_RS39210	COG0745	RESPONSE REGULATOR receiver
DC74_RS39215	COG5002	protein histidine kinase activity
DC74_RS39260	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DC74_RS39270	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DC74_RS39275	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DC74_RS39280	COG0318	PFAM AMP-dependent synthetase and ligase
DC74_RS39290	COG1250	3-hydroxyacyl-CoA dehydrogenase
DC74_RS39320	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DC74_RS39320	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DC74_RS39340	COG0596	Alpha beta hydrolase
DC74_RS39345	COG1309	transcriptional regulator
DC74_RS39355	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DC74_RS39370	COG3795	YCII-related domain
DC74_RS39375	COG4941	Belongs to the sigma-70 factor family
DC74_RS39380	COG1021	2,3-dihydroxybenzoate-AMP ligase
DC74_RS39385	COG2272	Belongs to the type-B carboxylesterase lipase family
DC74_RS39395	COG2814	Major facilitator Superfamily
DC74_RS39400	COG3979	chitinase
DC74_RS39520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DC74_RS39535	COG2197	response regulator
DC74_RS39545	COG1136	(ABC) transporter
DC74_RS39545	COG0577	efflux transmembrane transporter activity
DC74_RS39570	COG0666	response to abiotic stimulus
DC74_RS39585	COG2208	phosphoserine phosphatase activity
DC74_RS39585	COG2770	Histidine kinase
DC74_RS39665	COG1733	regulation of RNA biosynthetic process
DC74_RS39670	COG0702	epimerase
DC74_RS39695	COG0300	oxidoreductase activity
DC74_RS39730	COG0431	NADPH-dependent FMN reductase
DC74_RS39740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DC74_RS39780	COG1053	succinate dehydrogenase
DC74_RS39845	COG1309	transcriptional regulator
DC74_RS39900	COG4977	sequence-specific DNA binding
DC74_RS39965	COG1132	(ABC) transporter
DC74_RS40010	COG3321	synthase
DC74_RS40010	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS40010	COG0604	alcohol dehydrogenase
DC74_RS40015	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DC74_RS40145	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DC74_RS40160	COG2188	Transcriptional regulator
DC74_RS40260	COG1674	ftsk spoiiie
DC74_RS40270	COG2226	methyltransferase
DC74_RS40275	COG2186	Transcriptional regulator
DC74_RS40280	COG0515	serine threonine protein kinase
DC74_RS40280	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DC74_RS40290	COG0582	viral genome integration into host DNA
DC74_RS40305	COG0745	RESPONSE REGULATOR receiver
DC74_RS40345	COG1475	DNA binding
DC74_RS40365	COG1678	Uncharacterized ACR, COG1678
DC74_RS40425	COG0494	nUDIX hydrolase
DC74_RS40505	COG4221	oxidoreductase activity
DC74_RS40505	COG0300	oxidoreductase activity
DC74_RS40505	COG3321	synthase
DC74_RS40505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DC74_RS40510	COG0318	PFAM AMP-dependent synthetase and ligase
DC74_RS40510	COG0300	oxidoreductase activity
DC74_RS40510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DC74_RS40510	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS40510	COG3321	synthase
DC74_RS40515	COG3321	synthase
DC74_RS40515	COG0300	oxidoreductase activity
DC74_RS40515	COG1028	Short-chain dehydrogenase reductase Sdr
DC74_RS40515	COG0318	PFAM AMP-dependent synthetase and ligase
DC74_RS40515	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DC74_RS40530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DC74_RS40530	COG0300	oxidoreductase activity
DC74_RS40530	COG3321	synthase
DC74_RS40530	COG4221	oxidoreductase activity
DC74_RS40550	COG0477	Major facilitator Superfamily
DC74_RS40575	COG0494	nUDIX hydrolase
DC74_RS40585	COG0584	glycerophosphoryl diester phosphodiesterase
DC74_RS40635	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DC74_RS40640	COG2815	serine threonine protein kinase
DC74_RS40640	COG0515	serine threonine protein kinase
DC74_RS40670	COG0657	acetylesterase activity
DC74_RS40720	COG0515	serine threonine protein kinase
DC74_RS40720	COG2815	serine threonine protein kinase