locus-tag	class	description
MTP02_RS00055	COG3246	L-lysine catabolic process to acetate
MTP02_RS00085	COG0477	Major facilitator Superfamily
MTP02_RS00125	COG4335	DNA alkylation repair
MTP02_RS00130	COG3321	synthase
MTP02_RS00130	COG0604	alcohol dehydrogenase
MTP02_RS00150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MTP02_RS00165	COG1349	DNA-binding transcription factor activity
MTP02_RS00175	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
MTP02_RS00175	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MTP02_RS00175	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MTP02_RS00180	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MTP02_RS00180	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MTP02_RS00185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MTP02_RS00245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MTP02_RS00275	COG1695	Transcriptional regulator
MTP02_RS00300	COG1028	Short-chain dehydrogenase reductase Sdr
MTP02_RS00315	COG0513	Belongs to the DEAD box helicase family
MTP02_RS00325	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MTP02_RS00340	COG3217	Mosc domain protein beta barrel domain protein
MTP02_RS00340	COG0633	Ferredoxin
MTP02_RS00360	COG1349	DNA-binding transcription factor activity
MTP02_RS00380	COG1940	carbohydrate kinase activity
MTP02_RS00405	COG2197	response regulator
MTP02_RS00420	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MTP02_RS00445	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MTP02_RS00485	COG0584	glycerophosphoryl diester phosphodiesterase
MTP02_RS00500	COG1846	Transcriptional regulator
MTP02_RS00520	COG0671	phosphoesterase, PA-phosphatase related
MTP02_RS00550	COG2233	PERMEase
MTP02_RS00555	COG0640	Transcriptional regulator
MTP02_RS00560	COG1902	pentaerythritol trinitrate reductase activity
MTP02_RS00575	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MTP02_RS00590	COG2706	6-phosphogluconolactonase activity
MTP02_RS00605	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MTP02_RS00610	COG0071	Belongs to the small heat shock protein (HSP20) family
MTP02_RS00615	COG0076	glutamate decarboxylase activity
MTP02_RS00620	COG0243	molybdopterin cofactor binding
MTP02_RS00635	COG0303	'Molybdopterin
MTP02_RS00640	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MTP02_RS00655	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MTP02_RS00660	COG0583	DNA-binding transcription factor activity
MTP02_RS00705	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MTP02_RS00710	COG1120	ATPase activity
MTP02_RS00715	COG2207	Transcriptional regulator
MTP02_RS00720	COG2814	Major facilitator Superfamily
MTP02_RS00745	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MTP02_RS00760	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MTP02_RS00780	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MTP02_RS00800	COG0477	Major facilitator Superfamily
MTP02_RS00805	COG1309	transcriptional regulator
MTP02_RS00815	COG1472	Belongs to the glycosyl hydrolase 3 family
MTP02_RS00825	COG1175	transmembrane transport
MTP02_RS00835	COG1609	Transcriptional regulator
MTP02_RS00840	COG0432	Pfam Uncharacterised protein family UPF0047
MTP02_RS00845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MTP02_RS00850	COG1116	anion transmembrane transporter activity
MTP02_RS00860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MTP02_RS00865	COG0492	ferredoxin-NADP+ reductase activity
MTP02_RS00870	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MTP02_RS00875	COG1132	(ABC) transporter
MTP02_RS00895	COG1132	(ABC) transporter
MTP02_RS00900	COG1132	(ABC) transporter
MTP02_RS00915	COG1946	Acyl-CoA thioesterase
MTP02_RS00930	COG2018	Roadblock/LC7 domain
MTP02_RS00975	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MTP02_RS01020	COG2124	cytochrome p450
MTP02_RS01025	COG2130	NADP-dependent
MTP02_RS01030	COG1233	COG1233 Phytoene dehydrogenase and related
MTP02_RS01100	COG0477	Major facilitator Superfamily
MTP02_RS01110	COG0583	DNA-binding transcription factor activity
MTP02_RS01115	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MTP02_RS01120	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
MTP02_RS01125	COG1250	3-hydroxyacyl-CoA dehydrogenase
MTP02_RS01130	COG1960	acyl-CoA dehydrogenase activity
MTP02_RS01135	COG2391	methyltransferase activity
MTP02_RS01180	COG0740	serine-type endopeptidase activity
MTP02_RS01185	COG0740	serine-type endopeptidase activity
MTP02_RS01220	COG4521	taurine ABC transporter
MTP02_RS01225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MTP02_RS01245	COG3959	Transketolase, thiamine diphosphate binding domain
MTP02_RS01250	COG3958	Transketolase
MTP02_RS01320	COG2755	lipolytic protein G-D-S-L family
MTP02_RS01325	COG2365	Tyrosine phosphatase family
MTP02_RS01355	COG1657	PFAM Prenyltransferase squalene oxidase
MTP02_RS01365	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MTP02_RS01375	COG1562	ergosterol biosynthetic process
MTP02_RS01380	COG1134	teichoic acid transport
MTP02_RS01380	COG1388	LysM domain
MTP02_RS01405	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MTP02_RS01420	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
MTP02_RS01435	COG1024	Enoyl-CoA hydratase
MTP02_RS01450	COG2183	response to ionizing radiation
MTP02_RS01465	COG1802	Transcriptional regulator
MTP02_RS01470	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MTP02_RS01475	COG0402	S-adenosylhomocysteine deaminase activity
MTP02_RS01500	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MTP02_RS01505	COG0789	Transcriptional regulator
MTP02_RS01510	COG1024	Enoyl-CoA hydratase
MTP02_RS01510	COG1250	3-hydroxyacyl-CoA dehydrogenase
MTP02_RS01515	COG0183	Belongs to the thiolase family
MTP02_RS01530	COG1683	Conserved Protein
MTP02_RS01535	COG1515	deoxyribonuclease V activity
MTP02_RS01565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MTP02_RS01575	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MTP02_RS01575	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MTP02_RS01585	COG0488	(ABC) transporter
MTP02_RS01605	COG0438	transferase activity, transferring glycosyl groups
MTP02_RS01640	COG0254	rRNA binding
MTP02_RS01660	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
MTP02_RS01705	COG1793	dna ligase
MTP02_RS01710	COG1024	Enoyl-CoA hydratase
MTP02_RS01745	COG0789	Transcriptional regulator
MTP02_RS01790	COG1846	Transcriptional regulator
MTP02_RS01850	COG1012	belongs to the aldehyde dehydrogenase family
MTP02_RS01870	COG2814	Major facilitator Superfamily
MTP02_RS01875	COG2259	Doxx family
MTP02_RS01885	COG1869	D-ribose catabolic process
MTP02_RS01890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MTP02_RS01895	COG1172	Belongs to the binding-protein-dependent transport system permease family
MTP02_RS01900	COG1129	ABC transporter
MTP02_RS01905	COG1609	Transcriptional regulator
MTP02_RS01925	COG1295	ribonuclease BN
MTP02_RS01990	COG0673	inositol 2-dehydrogenase activity
MTP02_RS02000	COG1172	Belongs to the binding-protein-dependent transport system permease family
MTP02_RS02005	COG1129	ABC transporter
MTP02_RS02010	COG1940	carbohydrate kinase activity
MTP02_RS02015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MTP02_RS02030	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MTP02_RS02040	COG0583	DNA-binding transcription factor activity
MTP02_RS02045	COG1115	amino acid carrier protein
MTP02_RS02070	COG2154	pterin-4-alpha-carbinolamine dehydratase
MTP02_RS02105	COG1140	nitrate reductase beta subunit
MTP02_RS02165	COG0693	protein deglycase activity
MTP02_RS02175	COG1597	lipid kinase activity
MTP02_RS02180	COG4106	trans-aconitate 2-methyltransferase activity
MTP02_RS02195	COG3226	Transcriptional regulator
MTP02_RS02205	COG0604	alcohol dehydrogenase
MTP02_RS02220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MTP02_RS02240	COG1619	proteins homologs of microcin C7 resistance protein MccF
MTP02_RS02250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MTP02_RS02275	COG0596	Alpha beta hydrolase
MTP02_RS02295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MTP02_RS02300	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MTP02_RS02305	COG1120	ATPase activity
MTP02_RS02310	COG1250	3-hydroxyacyl-CoA dehydrogenase
MTP02_RS02320	COG0604	alcohol dehydrogenase
MTP02_RS02325	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MTP02_RS02325	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MTP02_RS02330	COG2301	Belongs to the HpcH HpaI aldolase family
MTP02_RS02345	COG0688	phosphatidylethanolamine metabolic process
MTP02_RS02355	COG1929	Belongs to the glycerate kinase type-1 family
MTP02_RS02360	COG0488	(ABC) transporter
MTP02_RS02370	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MTP02_RS02375	COG0702	epimerase
MTP02_RS02380	COG1028	Short-chain dehydrogenase reductase Sdr
MTP02_RS02390	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
MTP02_RS02415	COG0159	tryptophan synthase activity
MTP02_RS02430	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
MTP02_RS02445	COG0483	inositol monophosphate 1-phosphatase activity
MTP02_RS02455	COG0095	Lipoate-protein ligase
MTP02_RS02475	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MTP02_RS02500	COG0405	Gamma-glutamyltransferase
MTP02_RS02530	COG0765	amino acid transport
MTP02_RS02535	COG0765	amino acid transport
MTP02_RS02540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MTP02_RS02545	COG1126	abc transporter atp-binding protein
MTP02_RS02575	COG1228	amidohydrolase
MTP02_RS02580	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MTP02_RS02595	COG1960	acyl-CoA dehydrogenase activity
MTP02_RS02625	COG5183	chlorophyll binding
MTP02_RS02625	COG2133	pyrroloquinoline quinone binding
MTP02_RS02630	COG1132	(ABC) transporter
MTP02_RS02635	COG1132	(ABC) transporter
MTP02_RS02640	COG1120	ATPase activity
MTP02_RS02645	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MTP02_RS02650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MTP02_RS02655	COG2375	cellular response to nickel ion
MTP02_RS02660	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MTP02_RS02665	COG2207	Transcriptional regulator
MTP02_RS02695	COG2197	response regulator
MTP02_RS02705	COG0464	growth
MTP02_RS02785	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MTP02_RS02795	COG1940	carbohydrate kinase activity
MTP02_RS02805	COG1172	Belongs to the binding-protein-dependent transport system permease family
MTP02_RS02815	COG2188	Transcriptional regulator
MTP02_RS02820	COG0673	inositol 2-dehydrogenase activity
MTP02_RS02835	COG2197	response regulator
MTP02_RS02840	COG4585	Histidine kinase
MTP02_RS02855	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MTP02_RS02860	COG1414	Transcriptional regulator
MTP02_RS02875	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MTP02_RS02880	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
MTP02_RS02885	COG2080	2 iron, 2 sulfur cluster binding
MTP02_RS02890	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MTP02_RS02905	COG0667	Aldo Keto reductase
MTP02_RS02920	COG1960	acyl-CoA dehydrogenase activity
MTP02_RS02930	COG0235	Class ii aldolase
MTP02_RS02960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MTP02_RS02970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MTP02_RS02975	COG1028	Short-chain dehydrogenase reductase Sdr
MTP02_RS03000	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MTP02_RS03015	COG1028	Short-chain dehydrogenase reductase Sdr
MTP02_RS03040	COG1819	glycosyl
MTP02_RS03045	COG2124	cytochrome p450
MTP02_RS03055	COG0022	dehydrogenase e1 component
MTP02_RS03060	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MTP02_RS03065	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MTP02_RS03080	COG0656	L-ascorbic acid biosynthetic process
MTP02_RS03090	COG2197	response regulator
MTP02_RS03095	COG1309	transcriptional regulator
MTP02_RS03110	COG4941	Belongs to the sigma-70 factor family
MTP02_RS03115	COG3795	YCII-related domain
MTP02_RS03120	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MTP02_RS03125	COG1621	beta-fructofuranosidase activity
MTP02_RS03145	COG1609	Transcriptional regulator
MTP02_RS03190	COG2233	PERMEase
MTP02_RS03205	COG2351	hydroxyisourate hydrolase activity
MTP02_RS03225	COG3622	Belongs to the hyi family
MTP02_RS03230	COG2084	Dehydrogenase
MTP02_RS03235	COG0753	catalase activity
MTP02_RS03245	COG3960	tartronate-semialdehyde synthase activity
MTP02_RS03255	COG0318	PFAM AMP-dependent synthetase and ligase
MTP02_RS03260	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MTP02_RS03265	COG2197	response regulator
MTP02_RS03275	COG1309	transcriptional regulator
MTP02_RS03315	COG2252	PERMEase
MTP02_RS03320	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MTP02_RS03335	COG3835	regulator
MTP02_RS03340	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MTP02_RS03350	COG1802	Transcriptional regulator
MTP02_RS03365	COG1028	Short-chain dehydrogenase reductase Sdr
MTP02_RS03380	COG0028	Belongs to the TPP enzyme family
MTP02_RS03400	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MTP02_RS03405	COG1162	GTPase activity
MTP02_RS03415	COG2365	Tyrosine phosphatase family
MTP02_RS03455	COG1595	DNA-templated transcription, initiation
MTP02_RS03465	COG0789	Transcriptional regulator
MTP02_RS03475	COG0702	epimerase
MTP02_RS03480	COG1846	Transcriptional regulator
MTP02_RS03485	COG2409	Drug exporters of the RND superfamily
MTP02_RS03495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MTP02_RS03500	COG1120	ATPase activity
MTP02_RS03510	COG2255	four-way junction helicase activity
MTP02_RS03535	COG2040	homocysteine
MTP02_RS03555	COG1960	acyl-CoA dehydrogenase activity
MTP02_RS03560	COG0604	alcohol dehydrogenase
MTP02_RS03570	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MTP02_RS03585	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MTP02_RS03595	COG0175	sulfate reduction
MTP02_RS03625	COG1116	anion transmembrane transporter activity
MTP02_RS03630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MTP02_RS03645	COG0386	Belongs to the glutathione peroxidase family
MTP02_RS03680	COG5002	protein histidine kinase activity
MTP02_RS03680	COG2176	DNA-directed DNA polymerase activity
MTP02_RS03750	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MTP02_RS03755	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MTP02_RS03775	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MTP02_RS03780	COG1595	DNA-templated transcription, initiation
MTP02_RS03795	COG1028	Short-chain dehydrogenase reductase Sdr
MTP02_RS03805	COG0726	polysaccharide deacetylase
MTP02_RS03825	COG3253	May function as heme-dependent peroxidase
MTP02_RS03830	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MTP02_RS03840	COG0446	pyridine nucleotide-disulphide oxidoreductase
MTP02_RS03845	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MTP02_RS03865	COG0183	Belongs to the thiolase family
MTP02_RS03870	COG1024	Enoyl-CoA hydratase
MTP02_RS03870	COG1250	3-hydroxyacyl-CoA dehydrogenase
MTP02_RS03890	COG0531	amino acid
MTP02_RS03895	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MTP02_RS03900	COG4214	carbohydrate transport
MTP02_RS03910	COG4213	ABC transporter substrate-binding protein
MTP02_RS03920	COG0395	ABC-type sugar transport system, permease component
MTP02_RS03925	COG1175	transmembrane transport
MTP02_RS03930	COG1653	transport
MTP02_RS03935	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MTP02_RS03965	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MTP02_RS04015	COG1120	ATPase activity
MTP02_RS04020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MTP02_RS04025	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MTP02_RS04045	COG2235	arginine
MTP02_RS04050	COG1320	monovalent cation:proton antiporter activity
MTP02_RS04065	COG0651	ATP synthesis coupled electron transport
MTP02_RS04075	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MTP02_RS04075	COG2111	Na H antiporter
MTP02_RS04085	COG2124	cytochrome p450
MTP02_RS04115	COG0531	amino acid
MTP02_RS04120	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MTP02_RS04125	COG2235	arginine
MTP02_RS04145	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MTP02_RS04150	COG2890	protein-(glutamine-N5) methyltransferase activity
MTP02_RS04180	COG1799	cell septum assembly
MTP02_RS04190	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
MTP02_RS04205	COG1556	Lactate utilization protein
MTP02_RS04210	COG1139	Iron-sulfur cluster binding protein
MTP02_RS04215	COG0247	lactate metabolic process
MTP02_RS04220	COG1620	l-lactate permease
MTP02_RS04230	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MTP02_RS04270	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MTP02_RS04280	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MTP02_RS04295	COG1120	ATPase activity
MTP02_RS04300	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MTP02_RS04305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MTP02_RS04315	COG1733	regulation of RNA biosynthetic process
MTP02_RS04335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MTP02_RS04340	COG0601	transmembrane transport
MTP02_RS04350	COG0747	negative chemotaxis
MTP02_RS04360	COG1309	transcriptional regulator
MTP02_RS04375	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MTP02_RS04390	COG2936	dipeptidyl-peptidase activity
MTP02_RS04410	COG3540	Alkaline phosphatase
MTP02_RS04420	COG2050	protein possibly involved in aromatic compounds catabolism
MTP02_RS04435	COG0789	Transcriptional regulator
MTP02_RS04440	COG0640	Transcriptional regulator
MTP02_RS04460	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MTP02_RS04505	COG0438	transferase activity, transferring glycosyl groups
MTP02_RS04510	COG3226	Transcriptional regulator
MTP02_RS04515	COG0738	Major facilitator superfamily
MTP02_RS04530	COG4213	ABC transporter substrate-binding protein
MTP02_RS04535	COG1172	Belongs to the binding-protein-dependent transport system permease family
MTP02_RS04540	COG1172	Belongs to the binding-protein-dependent transport system permease family
MTP02_RS04550	COG1846	Transcriptional regulator
MTP02_RS04550	COG1940	carbohydrate kinase activity
MTP02_RS04555	COG0252	asparaginase activity
MTP02_RS04565	COG1028	Short-chain dehydrogenase reductase Sdr
MTP02_RS04585	COG1028	Short-chain dehydrogenase reductase Sdr
MTP02_RS04600	COG1028	Short-chain dehydrogenase reductase Sdr
MTP02_RS04635	COG0473	3-isopropylmalate dehydrogenase activity
MTP02_RS04650	COG0656	L-ascorbic acid biosynthetic process
MTP02_RS04685	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MTP02_RS04710	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MTP02_RS04720	COG1127	ABC transporter
MTP02_RS04765	COG0583	DNA-binding transcription factor activity
MTP02_RS04775	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MTP02_RS04790	COG4221	oxidoreductase activity
MTP02_RS04795	COG0300	oxidoreductase activity
MTP02_RS04850	COG2233	PERMEase
MTP02_RS04855	COG0402	S-adenosylhomocysteine deaminase activity
MTP02_RS04870	COG0559	Belongs to the binding-protein-dependent transport system permease family
MTP02_RS04905	COG0395	ABC-type sugar transport system, permease component
MTP02_RS04910	COG1063	alcohol dehydrogenase
MTP02_RS04925	COG0438	transferase activity, transferring glycosyl groups
MTP02_RS04930	COG2197	response regulator
MTP02_RS04940	COG1136	(ABC) transporter
MTP02_RS04955	COG2197	response regulator
MTP02_RS04965	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MTP02_RS04975	COG3251	PFAM MbtH domain protein
MTP02_RS04990	COG2175	clavaminate synthase activity
MTP02_RS05020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MTP02_RS05025	COG0531	amino acid
MTP02_RS05030	COG0569	domain protein
MTP02_RS05060	COG1136	(ABC) transporter
MTP02_RS05080	COG0756	dUTP diphosphatase activity
MTP02_RS05105	COG2205	protein histidine kinase activity
MTP02_RS05110	COG0745	RESPONSE REGULATOR receiver
MTP02_RS05120	COG0483	inositol monophosphate 1-phosphatase activity
MTP02_RS05125	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MTP02_RS05175	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MTP02_RS05180	COG1802	Transcriptional regulator
MTP02_RS05195	COG0612	Peptidase, M16
MTP02_RS05200	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MTP02_RS05210	COG0366	Alpha amylase catalytic
MTP02_RS05215	COG0395	ABC-type sugar transport system, permease component
MTP02_RS05220	COG1175	transmembrane transport
MTP02_RS05225	COG1653	transport
MTP02_RS05240	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MTP02_RS05275	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MTP02_RS05280	COG1802	Transcriptional regulator
MTP02_RS05315	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MTP02_RS05330	COG0588	phosphoglycerate mutase activity
MTP02_RS05350	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MTP02_RS05355	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MTP02_RS05360	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MTP02_RS05400	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MTP02_RS05410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MTP02_RS05415	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MTP02_RS05425	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MTP02_RS05445	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MTP02_RS05455	COG2205	protein histidine kinase activity
MTP02_RS05460	COG0745	RESPONSE REGULATOR receiver
MTP02_RS05465	COG1126	abc transporter atp-binding protein
MTP02_RS05470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MTP02_RS05475	COG0765	amino acid transport
MTP02_RS05480	COG0765	amino acid transport
MTP02_RS05485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MTP02_RS05500	COG2137	regulation of response to DNA damage stimulus
MTP02_RS05505	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MTP02_RS05530	COG0628	permease
MTP02_RS05555	COG1201	RNA secondary structure unwinding
MTP02_RS05560	COG0596	Alpha beta hydrolase
MTP02_RS05580	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MTP02_RS05590	COG0783	Belongs to the Dps family
MTP02_RS05595	COG1396	sequence-specific DNA binding
MTP02_RS05600	COG1058	Belongs to the CinA family
MTP02_RS05600	COG1546	Belongs to the CinA family
MTP02_RS05610	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MTP02_RS05620	COG1674	ftsk spoiiie
MTP02_RS05630	COG3850	Histidine kinase
MTP02_RS05630	COG4999	Histidine kinase
MTP02_RS05630	COG2205	protein histidine kinase activity
MTP02_RS05630	COG3437	response regulator, receiver
MTP02_RS05635	COG2208	phosphoserine phosphatase activity
MTP02_RS05635	COG2770	Histidine kinase
MTP02_RS05670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MTP02_RS05675	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
MTP02_RS05695	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MTP02_RS05700	COG0612	Peptidase, M16
MTP02_RS05705	COG1185	polyribonucleotide nucleotidyltransferase activity
MTP02_RS05710	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MTP02_RS05730	COG0455	bacterial-type flagellum organization
MTP02_RS05735	COG0747	negative chemotaxis
MTP02_RS05740	COG0601	transmembrane transport
MTP02_RS05745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MTP02_RS05750	COG0444	Belongs to the ABC transporter superfamily
MTP02_RS05755	COG4608	Belongs to the ABC transporter superfamily
MTP02_RS05760	COG1357	PFAM Pentapeptide repeats (8 copies)
MTP02_RS05775	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MTP02_RS05780	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MTP02_RS05790	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MTP02_RS05805	COG0779	Required for maturation of 30S ribosomal subunits
MTP02_RS05825	COG0442	prolyl-tRNA aminoacylation
MTP02_RS05845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MTP02_RS05850	COG0601	transmembrane transport
MTP02_RS05855	COG0747	negative chemotaxis
MTP02_RS05870	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MTP02_RS05875	COG0750	zinc metalloprotease
MTP02_RS05880	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MTP02_RS05885	COG1940	carbohydrate kinase activity
MTP02_RS05890	COG1012	belongs to the aldehyde dehydrogenase family
MTP02_RS05895	COG2508	Transcriptional regulator
MTP02_RS05925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MTP02_RS05930	COG1177	transmembrane transport
MTP02_RS05935	COG1176	ABC-type spermidine putrescine transport system, permease component I
MTP02_RS05940	COG3842	ATPase activity
MTP02_RS05950	COG1012	belongs to the aldehyde dehydrogenase family
MTP02_RS05965	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MTP02_RS05985	COG1012	belongs to the aldehyde dehydrogenase family
MTP02_RS05995	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MTP02_RS06020	COG3842	ATPase activity
MTP02_RS06025	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
MTP02_RS06035	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MTP02_RS06040	COG0575	Belongs to the CDS family
MTP02_RS06045	COG0233	cytoplasmic translational termination
MTP02_RS06055	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MTP02_RS06060	COG0052	Belongs to the universal ribosomal protein uS2 family
MTP02_RS06075	COG1191	sigma factor activity
MTP02_RS06090	COG0792	nuclease activity
MTP02_RS06105	COG0681	Belongs to the peptidase S26 family
MTP02_RS06110	COG0681	Belongs to the peptidase S26 family
MTP02_RS06120	COG0681	Belongs to the peptidase S26 family
MTP02_RS06125	COG0335	large ribosomal subunit rRNA binding
MTP02_RS06130	COG0336	Belongs to the RNA methyltransferase TrmD family
MTP02_RS06135	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MTP02_RS06140	COG1837	Belongs to the UPF0109 family
MTP02_RS06145	COG0228	four-way junction DNA binding
MTP02_RS06160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MTP02_RS06170	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
MTP02_RS06200	COG0477	Major facilitator Superfamily
MTP02_RS06205	COG1196	nuclear chromosome segregation
MTP02_RS06215	COG1254	Belongs to the acylphosphatase family
MTP02_RS06220	COG2340	Cysteine-rich secretory protein family
MTP02_RS06225	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MTP02_RS06230	COG0571	ribonuclease III activity
MTP02_RS06235	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MTP02_RS06250	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MTP02_RS06255	COG0742	ribosomal rna small subunit methyltransferase
MTP02_RS06265	COG1461	Dihydroxyacetone kinase
MTP02_RS06270	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MTP02_RS06275	COG0351	phosphomethylpyrimidine kinase
MTP02_RS06295	COG1181	Belongs to the D-alanine--D-alanine ligase family
MTP02_RS06300	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MTP02_RS06310	COG1920	GTP binding
MTP02_RS06320	COG0776	regulation of translation
MTP02_RS06330	COG0066	3-isopropylmalate dehydratase activity
MTP02_RS06335	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MTP02_RS06340	COG1414	Transcriptional regulator
MTP02_RS06385	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MTP02_RS06390	COG0179	Fumarylacetoacetate (FAA) hydrolase
MTP02_RS06405	COG2018	Roadblock/LC7 domain
MTP02_RS06425	COG2018	Roadblock/LC7 domain
MTP02_RS06445	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MTP02_RS06455	COG2353	YceI-like domain
MTP02_RS06495	COG0789	Transcriptional regulator
MTP02_RS06515	COG4221	oxidoreductase activity
MTP02_RS06550	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MTP02_RS06555	COG0477	Major facilitator Superfamily
MTP02_RS06560	COG2957	Belongs to the agmatine deiminase family
MTP02_RS06565	COG0804	urea catabolic process
MTP02_RS06570	COG0831	urea catabolic process
MTP02_RS06570	COG0832	Belongs to the urease beta subunit family
MTP02_RS06575	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MTP02_RS06580	COG0473	3-isopropylmalate dehydrogenase activity
MTP02_RS06605	COG1012	belongs to the aldehyde dehydrogenase family
MTP02_RS06610	COG0506	proline dehydrogenase activity
MTP02_RS06615	COG3835	regulator
MTP02_RS06635	COG2890	protein-(glutamine-N5) methyltransferase activity
MTP02_RS06645	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MTP02_RS06650	COG0440	acetolactate synthase activity
MTP02_RS06670	COG0667	Aldo Keto reductase
MTP02_RS06675	COG2133	pyrroloquinoline quinone binding
MTP02_RS06700	COG2197	response regulator
MTP02_RS06720	COG2409	Drug exporters of the RND superfamily
MTP02_RS06725	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MTP02_RS06735	COG0154	amidase activity
MTP02_RS06740	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MTP02_RS06750	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MTP02_RS06760	COG4221	oxidoreductase activity
MTP02_RS06780	COG0482	sulfurtransferase activity
MTP02_RS06805	COG2860	membrane
MTP02_RS06810	COG4608	Belongs to the ABC transporter superfamily
MTP02_RS06815	COG0444	Belongs to the ABC transporter superfamily
MTP02_RS06820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MTP02_RS06825	COG0601	transmembrane transport
MTP02_RS06830	COG0747	negative chemotaxis
MTP02_RS06850	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MTP02_RS06855	COG0509	glycine decarboxylation via glycine cleavage system
MTP02_RS06860	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MTP02_RS06865	COG1760	l-serine dehydratase
MTP02_RS06880	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
MTP02_RS06885	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
MTP02_RS06890	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
MTP02_RS06905	COG0477	Major facilitator Superfamily
MTP02_RS06920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MTP02_RS06945	COG2085	NADP oxidoreductase coenzyme F420-dependent
MTP02_RS06970	COG1376	ErfK ybiS ycfS ynhG family protein
MTP02_RS06995	COG1132	(ABC) transporter
MTP02_RS07000	COG1132	(ABC) transporter
MTP02_RS07010	COG1733	regulation of RNA biosynthetic process
MTP02_RS07030	COG0366	Alpha amylase catalytic
MTP02_RS07035	COG0366	Alpha amylase catalytic
MTP02_RS07040	COG3281	Trehalose synthase
MTP02_RS07045	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MTP02_RS07060	COG1119	ATPase activity
MTP02_RS07065	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MTP02_RS07080	COG1301	dicarboxylic acid transport
MTP02_RS07085	COG3290	protein histidine kinase activity
MTP02_RS07090	COG4565	transcriptional regulatory protein
MTP02_RS07095	COG0205	6-phosphofructokinase activity
MTP02_RS07100	COG0280	phosphate acetyltransferase
MTP02_RS07100	COG0857	belongs to the CobB CobQ family
MTP02_RS07105	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MTP02_RS07145	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MTP02_RS07145	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MTP02_RS07220	COG1335	isochorismatase
MTP02_RS07250	COG0183	Belongs to the thiolase family
MTP02_RS07270	COG1131	(ABC) transporter
MTP02_RS07305	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
MTP02_RS07320	COG1250	3-hydroxyacyl-CoA dehydrogenase
MTP02_RS07335	COG4585	Histidine kinase
MTP02_RS07340	COG2197	response regulator
MTP02_RS07360	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MTP02_RS07365	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MTP02_RS07370	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MTP02_RS07375	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MTP02_RS07380	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MTP02_RS07385	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MTP02_RS07390	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MTP02_RS07405	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MTP02_RS07410	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MTP02_RS07420	COG2890	protein-(glutamine-N5) methyltransferase activity
MTP02_RS07425	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MTP02_RS07430	COG0254	rRNA binding
MTP02_RS07435	COG1316	TRANSCRIPTIONal
MTP02_RS07445	COG0083	homoserine kinase activity
MTP02_RS07450	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MTP02_RS07455	COG0460	homoserine dehydrogenase
MTP02_RS07460	COG0019	diaminopimelate decarboxylase activity
MTP02_RS07465	COG0018	arginyl-trna synthetase
MTP02_RS07490	COG1012	belongs to the aldehyde dehydrogenase family
MTP02_RS07500	COG1191	sigma factor activity
MTP02_RS07505	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MTP02_RS07505	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MTP02_RS07515	COG2267	carboxylic ester hydrolase activity
MTP02_RS07520	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
MTP02_RS07535	COG0772	Belongs to the SEDS family
MTP02_RS07610	COG0726	polysaccharide deacetylase
MTP02_RS07615	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MTP02_RS07620	COG0477	Major facilitator Superfamily
MTP02_RS07645	COG1131	(ABC) transporter
MTP02_RS07670	COG0745	RESPONSE REGULATOR receiver
MTP02_RS07675	COG2205	protein histidine kinase activity
MTP02_RS07680	COG0508	dehydrogenase complex catalyzes the overall conversion of
MTP02_RS07680	COG0567	Dehydrogenase, E1 component
MTP02_RS07710	COG2255	four-way junction helicase activity
MTP02_RS07760	COG0604	alcohol dehydrogenase
MTP02_RS07765	COG0281	malic enzyme
MTP02_RS07780	COG1126	abc transporter atp-binding protein
MTP02_RS07785	COG4106	trans-aconitate 2-methyltransferase activity
MTP02_RS07835	COG0142	geranyltranstransferase activity
MTP02_RS07845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MTP02_RS07850	COG1959	2 iron, 2 sulfur cluster binding
MTP02_RS07870	COG2515	1-aminocyclopropane-1-carboxylate deaminase
MTP02_RS07885	COG2172	sigma factor antagonist activity
MTP02_RS07900	COG1597	lipid kinase activity
MTP02_RS07920	COG0363	glucosamine-6-phosphate deaminase activity
MTP02_RS07925	COG1472	Belongs to the glycosyl hydrolase 3 family
MTP02_RS07930	COG0395	ABC-type sugar transport system, permease component
MTP02_RS07935	COG1175	transmembrane transport
MTP02_RS07940	COG2182	Extracellular solute-binding protein
MTP02_RS07945	COG2188	Transcriptional regulator
MTP02_RS07950	COG1966	Carbon starvation protein
MTP02_RS07970	COG2124	cytochrome p450
MTP02_RS07980	COG0242	peptide deformylase activity
MTP02_RS07990	COG5662	AntiSigma factor
MTP02_RS07995	COG1595	DNA-templated transcription, initiation
MTP02_RS08005	COG2135	peptidase activity
MTP02_RS08015	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MTP02_RS08025	COG2076	Multidrug Resistance protein
MTP02_RS08035	COG0483	inositol monophosphate 1-phosphatase activity
MTP02_RS08040	COG0753	catalase activity
MTP02_RS08065	COG1615	UPF0182 protein
MTP02_RS08075	COG3480	Lon protease (S16) C-terminal proteolytic domain
MTP02_RS08170	COG0210	DNA helicase
MTP02_RS08260	COG0513	Belongs to the DEAD box helicase family
MTP02_RS08270	COG1432	Conserved Protein
MTP02_RS08280	COG2095	MarC family integral membrane protein
MTP02_RS08285	COG0613	PHP domain protein
MTP02_RS08290	COG2814	Major facilitator Superfamily
MTP02_RS08300	COG0598	Magnesium transport protein CorA
MTP02_RS08340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MTP02_RS08345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MTP02_RS08355	COG1595	DNA-templated transcription, initiation
MTP02_RS08370	COG1024	Enoyl-CoA hydratase
MTP02_RS08380	COG0519	Catalyzes the synthesis of GMP from XMP
MTP02_RS08415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MTP02_RS08445	COG0456	acetyltransferase
MTP02_RS08450	COG2912	Transglutaminase-like superfamily
MTP02_RS08460	COG1609	Transcriptional regulator
MTP02_RS08465	COG1172	Belongs to the binding-protein-dependent transport system permease family
MTP02_RS08475	COG1129	ABC transporter
MTP02_RS08480	COG1879	ABC-type sugar transport system periplasmic component
MTP02_RS08485	COG3250	beta-galactosidase activity
MTP02_RS08505	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MTP02_RS08530	COG4608	Belongs to the ABC transporter superfamily
MTP02_RS08540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MTP02_RS08545	COG0601	transmembrane transport
MTP02_RS08555	COG4608	Belongs to the ABC transporter superfamily
MTP02_RS08560	COG0444	Belongs to the ABC transporter superfamily
MTP02_RS08565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MTP02_RS08570	COG0601	transmembrane transport
MTP02_RS08580	COG1217	gtp-binding protein TYPA
MTP02_RS08635	COG1554	hydrolase, family 65, central catalytic
MTP02_RS08695	COG1028	Short-chain dehydrogenase reductase Sdr
MTP02_RS08710	COG3473	Maleate cis-trans isomerase
MTP02_RS08730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MTP02_RS08735	COG0765	amino acid transport
MTP02_RS08740	COG0765	amino acid transport
MTP02_RS08745	COG1126	abc transporter atp-binding protein
MTP02_RS08775	COG3397	chitin binding
MTP02_RS08830	COG0673	inositol 2-dehydrogenase activity
MTP02_RS08835	COG0179	Fumarylacetoacetate (FAA) hydrolase
MTP02_RS08840	COG0706	membrane insertase activity
MTP02_RS08890	COG2271	Major facilitator Superfamily
MTP02_RS08900	COG2733	membrane
MTP02_RS08930	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MTP02_RS08940	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MTP02_RS08965	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MTP02_RS08975	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MTP02_RS08980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MTP02_RS08985	COG1263	PTS System
MTP02_RS08995	COG1234	tRNA 3'-trailer cleavage
MTP02_RS09020	COG1113	amino acid transport
MTP02_RS09035	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MTP02_RS09045	COG1335	isochorismatase
MTP02_RS09075	COG0277	FAD linked oxidase domain protein
MTP02_RS09085	COG3185	4-Hydroxyphenylpyruvate dioxygenase
MTP02_RS09095	COG1174	glycine betaine transport
MTP02_RS09100	COG1125	glycine betaine transport
MTP02_RS09100	COG0517	IMP dehydrogenase activity
MTP02_RS09105	COG1174	glycine betaine transport
MTP02_RS09155	COG1116	anion transmembrane transporter activity
MTP02_RS09185	COG3293	Transposase
MTP02_RS09190	COG2318	DinB family
MTP02_RS09220	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MTP02_RS09245	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MTP02_RS09260	COG3525	Glycosyl hydrolase, family 20, catalytic domain
MTP02_RS09265	COG0395	ABC-type sugar transport system, permease component
MTP02_RS09270	COG1175	transmembrane transport
MTP02_RS09285	COG1678	Uncharacterized ACR, COG1678
MTP02_RS09290	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MTP02_RS09295	COG0776	regulation of translation
MTP02_RS09305	COG3973	AAA domain
MTP02_RS09305	COG3973	AAA domain
MTP02_RS09350	COG0583	DNA-binding transcription factor activity
MTP02_RS09365	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MTP02_RS09370	COG0793	Belongs to the peptidase S41A family
MTP02_RS09380	COG2884	Cell division ATP-binding protein ftsE
MTP02_RS09395	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MTP02_RS09400	COG0515	serine threonine protein kinase
MTP02_RS09405	COG0515	serine threonine protein kinase
MTP02_RS09410	COG1716	ATPase activity
MTP02_RS09420	COG1653	transport
MTP02_RS09425	COG1175	transmembrane transport
MTP02_RS09430	COG0395	ABC-type sugar transport system, permease component
MTP02_RS09435	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MTP02_RS09440	COG0438	transferase activity, transferring glycosyl groups
MTP02_RS09445	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MTP02_RS09460	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MTP02_RS09470	COG2226	methyltransferase
MTP02_RS09485	COG2902	Dehydrogenase
MTP02_RS09505	COG0583	DNA-binding transcription factor activity
MTP02_RS09520	COG0653	protein targeting
MTP02_RS09525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MTP02_RS09530	COG3214	Protein conserved in bacteria
MTP02_RS09535	COG2197	response regulator
MTP02_RS09540	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MTP02_RS09550	COG0823	Involved in the tonB-independent uptake of proteins
MTP02_RS09555	COG5002	protein histidine kinase activity
MTP02_RS09560	COG0745	RESPONSE REGULATOR receiver
MTP02_RS09565	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MTP02_RS09585	COG0714	Associated with various cellular activities
MTP02_RS09590	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
MTP02_RS09625	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MTP02_RS09635	COG1482	cell wall glycoprotein biosynthetic process
MTP02_RS09645	COG2835	tetraacyldisaccharide 4'-kinase activity
MTP02_RS09655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MTP02_RS09665	COG1620	l-lactate permease
MTP02_RS09700	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MTP02_RS09705	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
MTP02_RS09705	COG0778	Nitroreductase
MTP02_RS09735	COG1316	TRANSCRIPTIONal
MTP02_RS09755	COG1316	TRANSCRIPTIONal
MTP02_RS09760	COG3046	protein related to deoxyribodipyrimidine photolyase
MTP02_RS09810	COG0753	catalase activity
MTP02_RS09850	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MTP02_RS09860	COG2072	flavoprotein involved in K transport
MTP02_RS09885	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MTP02_RS09905	COG0745	RESPONSE REGULATOR receiver
MTP02_RS09910	COG3104	oligopeptide transport
MTP02_RS09920	COG1366	Belongs to the anti-sigma-factor antagonist family
MTP02_RS09925	COG1191	sigma factor activity
MTP02_RS09930	COG1228	amidohydrolase
MTP02_RS09960	COG0395	ABC-type sugar transport system, permease component
MTP02_RS10020	COG2755	lipolytic protein G-D-S-L family
MTP02_RS10025	COG0183	Belongs to the thiolase family
MTP02_RS10045	COG1476	TRANSCRIPTIONal
MTP02_RS10060	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MTP02_RS10070	COG1136	(ABC) transporter
MTP02_RS10075	COG0577	efflux transmembrane transporter activity
MTP02_RS10075	COG1136	(ABC) transporter
MTP02_RS10080	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MTP02_RS10085	COG1252	NADH dehydrogenase
MTP02_RS10115	COG0148	phosphopyruvate hydratase activity
MTP02_RS10130	COG2124	cytochrome p450
MTP02_RS10170	COG1733	regulation of RNA biosynthetic process
MTP02_RS10215	COG3226	Transcriptional regulator
MTP02_RS10225	COG1473	amidohydrolase
MTP02_RS10280	COG3629	intracellular signal transduction
MTP02_RS10280	COG3903	Transcriptional regulator
MTP02_RS10290	COG0477	Major facilitator Superfamily
MTP02_RS10330	COG0596	Alpha beta hydrolase
MTP02_RS10340	COG1316	TRANSCRIPTIONal
MTP02_RS10360	COG0789	Transcriptional regulator
MTP02_RS10385	COG4585	Histidine kinase
MTP02_RS10395	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MTP02_RS10400	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MTP02_RS10425	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MTP02_RS10430	COG0193	aminoacyl-tRNA hydrolase activity
MTP02_RS10440	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MTP02_RS10460	COG4106	trans-aconitate 2-methyltransferase activity
MTP02_RS10470	COG2197	response regulator
MTP02_RS10475	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MTP02_RS10520	COG0488	(ABC) transporter
MTP02_RS10525	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MTP02_RS10530	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MTP02_RS10535	COG0084	hydrolase, TatD family'
MTP02_RS10615	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MTP02_RS10625	COG2409	Drug exporters of the RND superfamily
MTP02_RS10635	COG0793	Belongs to the peptidase S41A family
MTP02_RS10635	COG4946	Tricorn protease homolog
MTP02_RS10645	COG4221	oxidoreductase activity
MTP02_RS10655	COG2072	flavoprotein involved in K transport
MTP02_RS10665	COG0708	Exodeoxyribonuclease III
MTP02_RS10675	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MTP02_RS10695	COG2197	response regulator
MTP02_RS10730	COG0521	Mo-molybdopterin cofactor biosynthetic process
MTP02_RS10730	COG0315	cyclic pyranopterin monophosphate synthase activity
MTP02_RS10735	COG0315	cyclic pyranopterin monophosphate synthase activity
MTP02_RS10745	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MTP02_RS10750	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MTP02_RS10760	COG3263	regulation of cellular component size
MTP02_RS10775	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MTP02_RS10790	COG1970	mechanosensitive ion channel activity
MTP02_RS10805	COG3191	aminopeptidase activity
MTP02_RS10825	COG3384	dioxygenase
MTP02_RS10830	COG1846	Transcriptional regulator
MTP02_RS10885	COG2050	protein possibly involved in aromatic compounds catabolism
MTP02_RS10895	COG0183	Belongs to the thiolase family
MTP02_RS10900	COG1024	Enoyl-CoA hydratase
MTP02_RS10905	COG1250	3-hydroxyacyl-CoA dehydrogenase
MTP02_RS10910	COG3396	Phenylacetate-CoA oxygenase
MTP02_RS10915	COG3460	Phenylacetate-CoA oxygenase
MTP02_RS10920	COG3396	Phenylacetate-CoA oxygenase
MTP02_RS10925	COG2151	metal-sulfur cluster biosynthetic enzyme
MTP02_RS10930	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MTP02_RS11000	COG0582	viral genome integration into host DNA
MTP02_RS11045	COG1609	Transcriptional regulator
MTP02_RS11125	COG1278	Cold shock
MTP02_RS11205	COG5297	Belongs to the glycosyl hydrolase family 6
MTP02_RS11225	COG0148	phosphopyruvate hydratase activity
MTP02_RS11240	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MTP02_RS11270	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MTP02_RS11310	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MTP02_RS11310	COG0515	serine threonine protein kinase
MTP02_RS11315	COG1309	transcriptional regulator
MTP02_RS11335	COG2072	flavoprotein involved in K transport
MTP02_RS11345	COG2271	Major facilitator Superfamily
MTP02_RS11365	COG1366	Belongs to the anti-sigma-factor antagonist family
MTP02_RS11445	COG4821	SIS domain
MTP02_RS11455	COG0259	pyridoxamine-phosphate oxidase activity
MTP02_RS11475	COG1024	Enoyl-CoA hydratase
MTP02_RS11490	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MTP02_RS11525	COG0583	DNA-binding transcription factor activity
MTP02_RS11535	COG0277	FAD linked oxidase domain protein
MTP02_RS11535	COG0247	lactate metabolic process
MTP02_RS11540	COG2205	protein histidine kinase activity
MTP02_RS11570	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MTP02_RS11665	COG0667	Aldo Keto reductase
MTP02_RS11690	COG2252	PERMEase
MTP02_RS11700	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MTP02_RS11735	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MTP02_RS11740	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
MTP02_RS11755	COG2197	response regulator
MTP02_RS11760	COG1132	(ABC) transporter
MTP02_RS11765	COG1132	(ABC) transporter
MTP02_RS11775	COG0515	serine threonine protein kinase
MTP02_RS11780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MTP02_RS11785	COG1120	ATPase activity
MTP02_RS11790	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MTP02_RS11795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MTP02_RS11805	COG1295	ribonuclease BN
MTP02_RS11815	COG2124	cytochrome p450
MTP02_RS11870	COG1061	Type III restriction enzyme res subunit
MTP02_RS11905	COG0667	Aldo Keto reductase
MTP02_RS11910	COG0789	Transcriptional regulator
MTP02_RS11935	COG3973	AAA domain
MTP02_RS11980	COG4585	Histidine kinase
MTP02_RS11985	COG2197	response regulator
MTP02_RS12020	COG0406	alpha-ribazole phosphatase activity
MTP02_RS12030	COG1737	Transcriptional regulator
MTP02_RS12035	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
MTP02_RS12040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MTP02_RS12040	COG1263	PTS System
MTP02_RS12045	COG0667	Aldo Keto reductase
MTP02_RS12080	COG1278	Cold shock
MTP02_RS12095	COG0463	Glycosyl transferase, family 2
MTP02_RS12120	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MTP02_RS12160	COG1105	Belongs to the carbohydrate kinase PfkB family
MTP02_RS12185	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MTP02_RS12215	COG1309	transcriptional regulator
MTP02_RS12230	COG0577	efflux transmembrane transporter activity
MTP02_RS12230	COG1136	(ABC) transporter
MTP02_RS12265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MTP02_RS12335	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MTP02_RS12405	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
MTP02_RS12420	COG1366	Belongs to the anti-sigma-factor antagonist family
MTP02_RS12425	COG1366	Belongs to the anti-sigma-factor antagonist family
MTP02_RS12430	COG2172	sigma factor antagonist activity
MTP02_RS12455	COG1136	(ABC) transporter
MTP02_RS12455	COG0577	efflux transmembrane transporter activity
MTP02_RS12460	COG0577	efflux transmembrane transporter activity
MTP02_RS12520	COG4585	Histidine kinase
MTP02_RS12525	COG2197	response regulator
MTP02_RS12530	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MTP02_RS12535	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MTP02_RS12555	COG0301	tRNA thio-modification
MTP02_RS12580	COG0513	Belongs to the DEAD box helicase family
MTP02_RS12585	COG1278	Cold shock
MTP02_RS12615	COG2208	phosphoserine phosphatase activity
MTP02_RS12615	COG2770	Histidine kinase
MTP02_RS12650	COG0456	acetyltransferase
MTP02_RS12660	COG0436	Aminotransferase
MTP02_RS12670	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MTP02_RS12680	COG3486	L-lysine 6-monooxygenase (NADPH) activity
MTP02_RS12690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MTP02_RS12690	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MTP02_RS12735	COG2814	Major facilitator Superfamily
MTP02_RS12790	COG1196	nuclear chromosome segregation
MTP02_RS12855	COG3842	ATPase activity
MTP02_RS12865	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MTP02_RS12875	COG1253	flavin adenine dinucleotide binding
MTP02_RS12890	COG0215	cysteine-tRNA ligase activity
MTP02_RS12905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MTP02_RS12925	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MTP02_RS12930	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MTP02_RS12935	COG1329	Transcriptional regulator
MTP02_RS12945	COG0745	RESPONSE REGULATOR receiver
MTP02_RS12950	COG5002	protein histidine kinase activity
MTP02_RS12965	COG2076	Multidrug Resistance protein
MTP02_RS12990	COG3311	Transcriptional regulator
MTP02_RS13045	COG2264	protein methyltransferase activity
MTP02_RS13050	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MTP02_RS13085	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
MTP02_RS13105	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MTP02_RS13110	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MTP02_RS13140	COG4942	peptidase
MTP02_RS13145	COG0783	Belongs to the Dps family
MTP02_RS13150	COG1120	ATPase activity
MTP02_RS13155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MTP02_RS13175	COG5001	Diguanylate cyclase
MTP02_RS13190	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MTP02_RS13195	COG0793	Belongs to the peptidase S41A family
MTP02_RS13215	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MTP02_RS13220	COG1316	TRANSCRIPTIONal
MTP02_RS13230	COG0640	Transcriptional regulator
MTP02_RS13240	COG1252	NADH dehydrogenase
MTP02_RS13270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MTP02_RS13280	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MTP02_RS13290	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MTP02_RS13330	COG2186	Transcriptional regulator
MTP02_RS13340	COG0318	PFAM AMP-dependent synthetase and ligase
MTP02_RS13345	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MTP02_RS13345	COG0825	malonyl-CoA metabolic process
MTP02_RS13355	COG0789	Transcriptional regulator
MTP02_RS13370	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MTP02_RS13375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MTP02_RS13390	COG0789	Transcriptional regulator
MTP02_RS13410	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MTP02_RS13425	COG2197	response regulator
MTP02_RS13455	COG2249	NAD(P)H dehydrogenase (quinone) activity
MTP02_RS13470	COG0537	adenosine 5'-monophosphoramidase activity
MTP02_RS13520	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MTP02_RS13605	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MTP02_RS13610	COG1754	DNA topoisomerase type I activity
MTP02_RS13610	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MTP02_RS13620	COG2890	protein-(glutamine-N5) methyltransferase activity
MTP02_RS13635	COG1366	Belongs to the anti-sigma-factor antagonist family
MTP02_RS13640	COG1111	helicase
MTP02_RS13640	COG1205	dead DEAH box helicase
MTP02_RS13700	COG0659	secondary active sulfate transmembrane transporter activity
MTP02_RS13705	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MTP02_RS13710	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MTP02_RS13720	COG2267	carboxylic ester hydrolase activity
MTP02_RS13750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MTP02_RS13760	COG0251	oxidation-reduction process
MTP02_RS13775	COG0003	Pfam Anion-transporting ATPase
MTP02_RS13810	COG0577	efflux transmembrane transporter activity
MTP02_RS13810	COG1136	(ABC) transporter
MTP02_RS13825	COG2318	DinB family
MTP02_RS13850	COG0596	Alpha beta hydrolase
MTP02_RS13870	COG2130	NADP-dependent
MTP02_RS13915	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MTP02_RS13920	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MTP02_RS13985	COG1733	regulation of RNA biosynthetic process
MTP02_RS13995	COG0666	response to abiotic stimulus
MTP02_RS14010	COG2197	response regulator
MTP02_RS14085	COG0596	Alpha beta hydrolase
MTP02_RS14160	COG1470	cell adhesion involved in biofilm formation
MTP02_RS14160	COG0366	Alpha amylase catalytic
MTP02_RS14175	COG0579	oxidoreductase
MTP02_RS14180	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MTP02_RS14190	COG0667	Aldo Keto reductase
MTP02_RS14220	COG0542	response to heat
MTP02_RS14250	COG0513	Belongs to the DEAD box helicase family
MTP02_RS14285	COG1643	Atp-dependent helicase
MTP02_RS14320	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MTP02_RS14335	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MTP02_RS14340	COG0047	phosphoribosylformylglycinamidine synthase activity
MTP02_RS14345	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MTP02_RS14380	COG2197	response regulator
MTP02_RS14390	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MTP02_RS14405	COG0151	Belongs to the GarS family
MTP02_RS14430	COG0659	secondary active sulfate transmembrane transporter activity
MTP02_RS14440	COG2837	iron assimilation
MTP02_RS14515	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MTP02_RS14550	COG1191	sigma factor activity
MTP02_RS14555	COG1191	sigma factor activity
MTP02_RS14570	COG0477	Major facilitator Superfamily
MTP02_RS14590	COG0477	Major facilitator Superfamily
MTP02_RS14600	COG0745	RESPONSE REGULATOR receiver
MTP02_RS14675	COG0270	DNA (cytosine-5-)-methyltransferase activity
MTP02_RS14715	COG0318	PFAM AMP-dependent synthetase and ligase
MTP02_RS14720	COG1595	DNA-templated transcription, initiation
MTP02_RS14740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MTP02_RS14755	COG0653	protein targeting
MTP02_RS14770	COG0006	proline dipeptidase activity
MTP02_RS14790	COG1999	signal sequence binding
MTP02_RS14805	COG2837	iron assimilation
MTP02_RS14810	COG0077	Prephenate dehydratase
MTP02_RS14815	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MTP02_RS14820	COG0561	phosphatase activity
MTP02_RS14840	COG1131	(ABC) transporter
MTP02_RS14860	COG0561	phosphatase activity
MTP02_RS14865	COG0739	heme binding
MTP02_RS14865	COG0741	lytic transglycosylase activity
MTP02_RS14865	COG1196	nuclear chromosome segregation
MTP02_RS14875	COG4988	ABC transporter
MTP02_RS14880	COG1294	oxidase, subunit
MTP02_RS14885	COG1271	oxidase subunit
MTP02_RS14890	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MTP02_RS14895	COG1609	Transcriptional regulator
MTP02_RS14910	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MTP02_RS14935	COG0662	Cupin 2, conserved barrel domain protein
MTP02_RS14940	COG1950	PFAM Membrane protein of
MTP02_RS14945	COG0626	cystathionine gamma-synthase activity
MTP02_RS14990	COG0110	maltose O-acetyltransferase activity
MTP02_RS14995	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MTP02_RS15085	COG0305	Participates in initiation and elongation during chromosome replication
MTP02_RS15095	COG0359	binds to the 23S rRNA
MTP02_RS15100	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MTP02_RS15105	COG0629	single-stranded DNA binding
MTP02_RS15110	COG0360	Binds together with S18 to 16S ribosomal RNA
MTP02_RS15135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MTP02_RS15160	COG0617	tRNA 3'-terminal CCA addition
MTP02_RS15175	COG2815	serine threonine protein kinase
MTP02_RS15175	COG0515	serine threonine protein kinase
MTP02_RS15180	COG1595	DNA-templated transcription, initiation
MTP02_RS15190	COG0492	ferredoxin-NADP+ reductase activity
MTP02_RS15195	COG3118	belongs to the thioredoxin family
MTP02_RS15210	COG1192	Involved in chromosome partitioning
MTP02_RS15215	COG0357	Ribosomal RNA small subunit methyltransferase G
MTP02_RS15225	COG0706	membrane insertase activity
MTP02_RS15230	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MTP02_RS15235	COG0594	ribonuclease P activity
MTP02_RS15240	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MTP02_RS15250	COG0592	DNA-directed DNA polymerase activity
MTP02_RS15255	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
MTP02_RS15260	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MTP02_RS15265	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
MTP02_RS15270	COG0187	DNA topoisomerase II activity
MTP02_RS15275	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MTP02_RS15315	COG0515	serine threonine protein kinase
MTP02_RS15345	COG1278	Cold shock
MTP02_RS15350	COG1309	transcriptional regulator
MTP02_RS15370	COG0705	Rhomboid family
MTP02_RS15390	COG3764	Sortase (surface protein transpeptidase)
MTP02_RS15395	COG3764	Sortase (surface protein transpeptidase)
MTP02_RS15400	COG0515	serine threonine protein kinase
MTP02_RS15420	COG1716	ATPase activity
MTP02_RS15425	COG1716	ATPase activity
MTP02_RS15435	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MTP02_RS15440	COG1733	regulation of RNA biosynthetic process
MTP02_RS15485	COG1522	sequence-specific DNA binding
MTP02_RS15510	COG0303	'Molybdopterin
MTP02_RS15515	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MTP02_RS15540	COG0515	serine threonine protein kinase
MTP02_RS15545	COG0515	serine threonine protein kinase
MTP02_RS15560	COG0022	dehydrogenase e1 component
MTP02_RS15565	COG0508	dehydrogenase complex catalyzes the overall conversion of
MTP02_RS15620	COG1362	aminopeptidase activity
MTP02_RS15640	COG1960	acyl-CoA dehydrogenase activity
MTP02_RS15650	COG1741	Belongs to the pirin family
MTP02_RS15655	COG0628	permease
MTP02_RS15665	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MTP02_RS15675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MTP02_RS15715	COG1316	TRANSCRIPTIONal
MTP02_RS15730	COG2268	Band 7 protein
MTP02_RS15735	COG1937	Protein conserved in bacteria
MTP02_RS15740	COG1064	alcohol dehydrogenase
MTP02_RS15745	COG2770	Histidine kinase
MTP02_RS15745	COG2208	phosphoserine phosphatase activity
MTP02_RS15775	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MTP02_RS15795	COG0477	Major facilitator Superfamily
MTP02_RS15820	COG0657	acetylesterase activity
MTP02_RS15825	COG0247	lactate metabolic process
MTP02_RS15825	COG2181	nitrate reductase activity
MTP02_RS15830	COG1434	Gram-negative-bacterium-type cell wall biogenesis
MTP02_RS15870	COG0717	Belongs to the dCTP deaminase family
MTP02_RS15880	COG0326	Molecular chaperone. Has ATPase activity
MTP02_RS15900	COG2814	Major facilitator Superfamily
MTP02_RS15910	COG1695	Transcriptional regulator
MTP02_RS15940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MTP02_RS15940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MTP02_RS15975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MTP02_RS15980	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MTP02_RS15985	COG1120	ATPase activity
MTP02_RS16010	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
MTP02_RS16040	COG1131	(ABC) transporter
MTP02_RS16045	COG1725	Transcriptional regulator
MTP02_RS16080	COG0443	Heat shock 70 kDa protein
MTP02_RS16085	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MTP02_RS16090	COG0484	heat shock protein binding
MTP02_RS16095	COG0789	Transcriptional regulator
MTP02_RS16120	COG0477	Major facilitator Superfamily
MTP02_RS16135	COG2378	regulation of single-species biofilm formation
MTP02_RS16185	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MTP02_RS16200	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MTP02_RS16205	COG0191	fructose-bisphosphate aldolase activity
MTP02_RS16210	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MTP02_RS16215	COG0477	Major facilitator Superfamily
MTP02_RS16235	COG3844	kynureninase activity
MTP02_RS16245	COG0702	epimerase
MTP02_RS16250	COG4585	Histidine kinase
MTP02_RS16255	COG2197	response regulator
MTP02_RS16265	COG1335	isochorismatase
MTP02_RS16280	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MTP02_RS16295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MTP02_RS16300	COG0798	PFAM Bile acid sodium symporter
MTP02_RS16320	COG2124	cytochrome p450
MTP02_RS16325	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MTP02_RS16330	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MTP02_RS16340	COG0477	Major facilitator Superfamily
MTP02_RS16390	COG0509	glycine decarboxylation via glycine cleavage system
MTP02_RS16400	COG2318	DinB family
MTP02_RS16420	COG1196	nuclear chromosome segregation
MTP02_RS16420	COG0739	heme binding
MTP02_RS16420	COG0741	lytic transglycosylase activity
MTP02_RS16440	COG1028	Short-chain dehydrogenase reductase Sdr
MTP02_RS16450	COG1937	Protein conserved in bacteria
MTP02_RS16460	COG0306	phosphate transporter
MTP02_RS16465	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MTP02_RS16485	COG0494	nUDIX hydrolase
MTP02_RS16485	COG0406	alpha-ribazole phosphatase activity
MTP02_RS16520	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MTP02_RS16525	COG2318	DinB family
MTP02_RS16570	COG2770	Histidine kinase
MTP02_RS16570	COG2208	phosphoserine phosphatase activity
MTP02_RS16580	COG0596	Alpha beta hydrolase
MTP02_RS16585	COG3629	intracellular signal transduction
MTP02_RS16585	COG3903	Transcriptional regulator
MTP02_RS16625	COG1595	DNA-templated transcription, initiation
MTP02_RS16680	COG2267	carboxylic ester hydrolase activity
MTP02_RS16715	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MTP02_RS16725	COG1131	(ABC) transporter
MTP02_RS16735	COG1725	Transcriptional regulator
MTP02_RS16740	COG4941	Belongs to the sigma-70 factor family
MTP02_RS16790	COG0456	acetyltransferase
MTP02_RS16795	COG0737	Belongs to the 5'-nucleotidase family
MTP02_RS16800	COG0235	Class ii aldolase
MTP02_RS16805	COG2160	L-arabinose isomerase activity
MTP02_RS16815	COG1609	Transcriptional regulator
MTP02_RS16825	COG1129	ABC transporter
MTP02_RS16830	COG4214	carbohydrate transport
MTP02_RS16845	COG0745	RESPONSE REGULATOR receiver
MTP02_RS16850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MTP02_RS16855	COG1609	Transcriptional regulator
MTP02_RS16860	COG0745	RESPONSE REGULATOR receiver
MTP02_RS16885	COG2897	thiosulfate sulfurtransferase activity
MTP02_RS16920	COG3485	protocatechuate 3,4-dioxygenase
MTP02_RS16925	COG0735	belongs to the Fur family
MTP02_RS16930	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MTP02_RS16935	COG1490	D-aminoacyl-tRNA deacylase activity
MTP02_RS16950	COG0789	Transcriptional regulator
MTP02_RS16955	COG2249	NAD(P)H dehydrogenase (quinone) activity
MTP02_RS16970	COG1476	TRANSCRIPTIONal
MTP02_RS17005	COG4106	trans-aconitate 2-methyltransferase activity
MTP02_RS17025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MTP02_RS17035	COG2226	methyltransferase
MTP02_RS17055	COG1309	transcriptional regulator
MTP02_RS17110	COG0457	Tetratricopeptide repeat
MTP02_RS17135	COG0791	NLP P60 protein
MTP02_RS17135	COG3103	Sh3 type 3 domain protein
MTP02_RS17135	COG1388	LysM domain
MTP02_RS17145	COG0438	transferase activity, transferring glycosyl groups
MTP02_RS17170	COG0588	phosphoglycerate mutase activity
MTP02_RS17195	COG0739	heme binding
MTP02_RS17210	COG2814	Major facilitator Superfamily
MTP02_RS17210	COG0477	Major facilitator Superfamily
MTP02_RS17225	COG2159	amidohydrolase
MTP02_RS17230	COG2828	Protein conserved in bacteria
MTP02_RS17235	COG2186	Transcriptional regulator
MTP02_RS17265	COG0501	Belongs to the peptidase M48B family
MTP02_RS17270	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MTP02_RS17270	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MTP02_RS17315	COG1289	transmembrane transporter activity
MTP02_RS17340	COG1012	belongs to the aldehyde dehydrogenase family
MTP02_RS17345	COG2318	DinB family
MTP02_RS17355	COG0655	NAD(P)H dehydrogenase (quinone) activity
MTP02_RS17360	COG0789	Transcriptional regulator
MTP02_RS17365	COG0586	Pfam SNARE associated Golgi protein
MTP02_RS17375	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MTP02_RS17380	COG2027	D-alanyl-D-alanine carboxypeptidase
MTP02_RS17390	COG0037	tRNA processing
MTP02_RS17405	COG0302	gtp cyclohydrolase
MTP02_RS17415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MTP02_RS17420	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MTP02_RS17435	COG0517	IMP dehydrogenase activity
MTP02_RS17435	COG1125	glycine betaine transport
MTP02_RS17440	COG1174	glycine betaine transport
MTP02_RS17445	COG1174	glycine betaine transport
MTP02_RS17450	COG1732	Glycine betaine
MTP02_RS17460	COG0477	Major facilitator Superfamily
MTP02_RS17475	COG0477	Major facilitator Superfamily
MTP02_RS17545	COG1012	belongs to the aldehyde dehydrogenase family
MTP02_RS17565	COG4585	Histidine kinase
MTP02_RS17570	COG2197	response regulator
MTP02_RS17590	COG0649	NAD binding
MTP02_RS17605	COG2197	response regulator
MTP02_RS17620	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MTP02_RS17625	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MTP02_RS17635	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MTP02_RS17655	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MTP02_RS17680	COG0739	heme binding
MTP02_RS17685	COG2205	protein histidine kinase activity
MTP02_RS17690	COG0745	RESPONSE REGULATOR receiver
MTP02_RS17700	COG1595	DNA-templated transcription, initiation
MTP02_RS17710	COG0671	phosphoesterase, PA-phosphatase related
MTP02_RS17720	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
MTP02_RS17755	COG0248	Ppx GppA phosphatase
MTP02_RS17765	COG1082	Xylose isomerase domain protein TIM barrel
MTP02_RS17770	COG1309	transcriptional regulator
MTP02_RS17775	COG0129	dihydroxy-acid dehydratase activity
MTP02_RS17785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MTP02_RS17805	COG1129	ABC transporter
MTP02_RS17805	COG0842	Transport permease protein
MTP02_RS17815	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MTP02_RS17820	COG0180	Tryptophanyl-tRNA synthetase
MTP02_RS17845	COG2223	nitrite transmembrane transporter activity
MTP02_RS17850	COG0123	including yeast histone deacetylase and acetoin utilization protein
MTP02_RS17880	COG4552	Acetyltransferase involved in intracellular survival and related
MTP02_RS17905	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
MTP02_RS17910	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MTP02_RS17915	COG0181	hydroxymethylbilane synthase activity
MTP02_RS17920	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MTP02_RS17920	COG1648	precorrin-2 dehydrogenase activity
MTP02_RS17925	COG0113	porphobilinogen synthase activity
MTP02_RS17945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MTP02_RS17950	COG0018	arginyl-trna synthetase
MTP02_RS17955	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
MTP02_RS17980	COG1690	Belongs to the RtcB family
MTP02_RS17985	COG0659	secondary active sulfate transmembrane transporter activity
MTP02_RS18030	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MTP02_RS18035	COG0406	alpha-ribazole phosphatase activity
MTP02_RS18045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MTP02_RS18050	COG0785	Cytochrome C biogenesis protein
MTP02_RS18060	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MTP02_RS18075	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MTP02_RS18080	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MTP02_RS18085	COG0163	prenyltransferase activity
MTP02_RS18100	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MTP02_RS18115	COG1301	dicarboxylic acid transport
MTP02_RS18130	COG1131	(ABC) transporter
MTP02_RS18135	COG3559	Exporter of polyketide antibiotics
MTP02_RS18165	COG0183	Belongs to the thiolase family
MTP02_RS18175	COG1278	Cold shock
MTP02_RS18180	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
MTP02_RS18300	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
MTP02_RS18360	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MTP02_RS18370	COG2226	methyltransferase
MTP02_RS18395	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MTP02_RS18400	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MTP02_RS18405	COG0649	NAD binding
MTP02_RS18415	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
MTP02_RS18420	COG1034	ATP synthesis coupled electron transport
MTP02_RS18425	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MTP02_RS18430	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MTP02_RS18435	COG0839	Belongs to the complex I subunit 6 family
MTP02_RS18440	COG0713	ATP synthesis coupled electron transport
MTP02_RS18445	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MTP02_RS18455	COG1007	ATP synthesis coupled electron transport
MTP02_RS18460	COG0514	ATP-dependent DNA helicase (RecQ)
MTP02_RS18480	COG0561	phosphatase activity
MTP02_RS18490	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MTP02_RS18505	COG3104	oligopeptide transport
MTP02_RS18510	COG0142	geranyltranstransferase activity
MTP02_RS18570	COG0488	(ABC) transporter
MTP02_RS18580	COG0702	epimerase
MTP02_RS18585	COG1733	regulation of RNA biosynthetic process
MTP02_RS18590	COG1013	pyruvate-flavodoxin oxidoreductase activity
MTP02_RS18595	COG0674	pyruvate-flavodoxin oxidoreductase activity
MTP02_RS18595	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MTP02_RS18600	COG2197	response regulator
MTP02_RS18605	COG4585	Histidine kinase
MTP02_RS18615	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MTP02_RS18620	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MTP02_RS18625	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MTP02_RS18630	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MTP02_RS18635	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MTP02_RS18640	COG0839	Belongs to the complex I subunit 6 family
MTP02_RS18645	COG0713	ATP synthesis coupled electron transport
MTP02_RS18650	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MTP02_RS18660	COG1007	ATP synthesis coupled electron transport
MTP02_RS18665	COG0501	Belongs to the peptidase M48B family
MTP02_RS18670	COG3304	Inner membrane component domain
MTP02_RS18675	COG2261	transglycosylase associated protein
MTP02_RS18680	COG1666	GTP binding
MTP02_RS18695	COG0702	epimerase
MTP02_RS18700	COG0402	S-adenosylhomocysteine deaminase activity
MTP02_RS18715	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MTP02_RS18720	COG2030	dehydratase
MTP02_RS18730	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MTP02_RS18740	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MTP02_RS18770	COG0081	regulation of translation
MTP02_RS18780	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MTP02_RS18785	COG0222	ribosome binding
MTP02_RS18790	COG0085	RNA polymerase activity
MTP02_RS18795	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MTP02_RS18830	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MTP02_RS18835	COG0049	tRNA binding
MTP02_RS18840	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MTP02_RS18860	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MTP02_RS18870	COG0051	transcription antitermination factor activity, RNA binding
MTP02_RS18875	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MTP02_RS18880	COG0088	Forms part of the polypeptide exit tunnel
MTP02_RS18885	COG0089	rRNA binding
MTP02_RS18890	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MTP02_RS18895	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MTP02_RS18900	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MTP02_RS18905	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MTP02_RS18910	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MTP02_RS18915	COG0255	Belongs to the universal ribosomal protein uL29 family
MTP02_RS18920	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MTP02_RS18925	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MTP02_RS18930	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MTP02_RS18935	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MTP02_RS18940	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MTP02_RS18945	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MTP02_RS18950	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MTP02_RS18955	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MTP02_RS18960	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MTP02_RS18965	COG1841	ribosomal large subunit assembly
MTP02_RS18970	COG0200	Binds to the 23S rRNA
MTP02_RS18975	COG0201	protein transport
MTP02_RS18980	COG0563	adenylate kinase activity
MTP02_RS18990	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MTP02_RS18995	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MTP02_RS19000	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MTP02_RS19005	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MTP02_RS19015	COG0203	ribosomal protein L17
MTP02_RS19030	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MTP02_RS19035	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MTP02_RS19040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MTP02_RS19045	COG1072	(Pantothenic acid kinase))
MTP02_RS19060	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MTP02_RS19075	COG4977	sequence-specific DNA binding
MTP02_RS19090	COG0736	holo-[acyl-carrier-protein] synthase activity
MTP02_RS19155	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MTP02_RS19160	COG2267	carboxylic ester hydrolase activity
MTP02_RS19165	COG0802	atpase or kinase
MTP02_RS19190	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MTP02_RS19225	COG0726	polysaccharide deacetylase
MTP02_RS19240	COG4221	oxidoreductase activity
MTP02_RS19245	COG0583	DNA-binding transcription factor activity
MTP02_RS19255	COG2197	response regulator
MTP02_RS19260	COG1595	DNA-templated transcription, initiation
MTP02_RS19270	COG0516	GMP reductase activity
MTP02_RS19280	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MTP02_RS19320	COG1012	belongs to the aldehyde dehydrogenase family
MTP02_RS19340	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MTP02_RS19340	COG0519	Catalyzes the synthesis of GMP from XMP
MTP02_RS19350	COG1028	Short-chain dehydrogenase reductase Sdr
MTP02_RS19390	COG2197	response regulator
MTP02_RS19395	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MTP02_RS19440	COG0456	acetyltransferase
MTP02_RS19440	COG1846	Transcriptional regulator
MTP02_RS19450	COG1228	amidohydrolase
MTP02_RS19470	COG0791	NLP P60 protein
MTP02_RS19510	COG2066	Belongs to the glutaminase family
MTP02_RS19515	COG1196	nuclear chromosome segregation
MTP02_RS19515	COG0741	lytic transglycosylase activity
MTP02_RS19515	COG0739	heme binding
MTP02_RS19520	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
MTP02_RS19525	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MTP02_RS19525	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MTP02_RS19540	COG0714	Associated with various cellular activities
MTP02_RS19545	COG2425	protein containing a von Willebrand factor type A (vWA) domain
MTP02_RS19550	COG3552	Protein containing von Willebrand factor type A (VWA) domain
MTP02_RS19555	COG0045	succinate-CoA ligase (ADP-forming) activity
MTP02_RS19585	COG0138	bifunctional purine biosynthesis protein purh
MTP02_RS19595	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MTP02_RS19620	COG0039	L-malate dehydrogenase activity
MTP02_RS19640	COG1012	belongs to the aldehyde dehydrogenase family
MTP02_RS19650	COG0517	IMP dehydrogenase activity
MTP02_RS19650	COG4175	Glycine betaine
MTP02_RS19680	COG0395	ABC-type sugar transport system, permease component
MTP02_RS19685	COG1175	transmembrane transport
MTP02_RS19705	COG2362	D-Aminopeptidase
MTP02_RS19710	COG1609	Transcriptional regulator
MTP02_RS19720	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MTP02_RS19725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MTP02_RS19735	COG0754	glutathionylspermidine amidase activity
MTP02_RS19745	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MTP02_RS19785	COG0180	Tryptophanyl-tRNA synthetase
MTP02_RS19825	COG1295	ribonuclease BN
MTP02_RS19840	COG1408	metallophosphoesterase
MTP02_RS19875	COG1309	transcriptional regulator
MTP02_RS19890	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MTP02_RS19895	COG1053	succinate dehydrogenase
MTP02_RS19905	COG2009	succinate dehydrogenase
MTP02_RS19945	COG1215	transferase activity, transferring glycosyl groups
MTP02_RS19950	COG1595	DNA-templated transcription, initiation
MTP02_RS20020	COG1216	Glycosyl transferase, family 2
MTP02_RS20030	COG1083	cytidylyl-transferase
MTP02_RS20035	COG2089	acid synthase
MTP02_RS20045	COG1473	amidohydrolase
MTP02_RS20045	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MTP02_RS20085	COG1744	ABC transporter substrate-binding protein PnrA-like
MTP02_RS20090	COG3845	ABC transporter
MTP02_RS20095	COG4603	Belongs to the binding-protein-dependent transport system permease family
MTP02_RS20100	COG1079	Belongs to the binding-protein-dependent transport system permease family
MTP02_RS20140	COG2814	Major facilitator Superfamily
MTP02_RS20145	COG0583	DNA-binding transcription factor activity
MTP02_RS20170	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MTP02_RS20195	COG2205	protein histidine kinase activity
MTP02_RS20200	COG0745	RESPONSE REGULATOR receiver
MTP02_RS20205	COG1595	DNA-templated transcription, initiation
MTP02_RS20255	COG1012	belongs to the aldehyde dehydrogenase family
MTP02_RS20275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MTP02_RS20315	COG4770	biotin carboxylase activity
MTP02_RS20325	COG0424	maF-like protein
MTP02_RS20340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MTP02_RS20350	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
MTP02_RS20355	COG1024	Enoyl-CoA hydratase
MTP02_RS20365	COG2986	histidine ammonia-lyase
MTP02_RS20385	COG1136	(ABC) transporter
MTP02_RS20390	COG1064	alcohol dehydrogenase
MTP02_RS20395	COG2318	DinB family
MTP02_RS20420	COG2255	four-way junction helicase activity
MTP02_RS20425	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MTP02_RS20440	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MTP02_RS20450	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MTP02_RS20485	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MTP02_RS20510	COG1331	Highly conserved protein containing a thioredoxin domain
MTP02_RS20530	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
MTP02_RS20560	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
MTP02_RS20575	COG1414	Transcriptional regulator
MTP02_RS20580	COG0251	oxidation-reduction process
MTP02_RS20660	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MTP02_RS20695	COG2894	cell division
MTP02_RS20725	COG2197	response regulator
MTP02_RS20760	COG2814	Major facilitator Superfamily
MTP02_RS20765	COG0656	L-ascorbic acid biosynthetic process
MTP02_RS20770	COG2304	oxidoreductase activity
MTP02_RS20780	COG3548	integral membrane protein
MTP02_RS20790	COG0667	Aldo Keto reductase
MTP02_RS20795	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MTP02_RS20800	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MTP02_RS20820	COG0450	alkyl hydroperoxide reductase
MTP02_RS20825	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MTP02_RS20835	COG1136	(ABC) transporter
MTP02_RS20855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MTP02_RS20870	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MTP02_RS20880	COG0114	fumarate hydratase activity
MTP02_RS20890	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
MTP02_RS20890	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
MTP02_RS20925	COG0778	Nitroreductase
MTP02_RS20930	COG1722	exodeoxyribonuclease VII activity
MTP02_RS20935	COG1570	exodeoxyribonuclease VII activity
MTP02_RS20940	COG0531	amino acid
MTP02_RS20945	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MTP02_RS20960	COG0012	GTP binding
MTP02_RS20995	COG0709	Synthesizes selenophosphate from selenide and ATP
MTP02_RS21030	COG0406	alpha-ribazole phosphatase activity
MTP02_RS21055	COG0745	RESPONSE REGULATOR receiver
MTP02_RS21125	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MTP02_RS21130	COG4977	sequence-specific DNA binding
MTP02_RS21145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MTP02_RS21170	COG3486	L-lysine 6-monooxygenase (NADPH) activity
MTP02_RS21200	COG1028	Short-chain dehydrogenase reductase Sdr
MTP02_RS21210	COG3655	Transcriptional regulator
MTP02_RS21270	COG1960	acyl-CoA dehydrogenase activity
MTP02_RS21285	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MTP02_RS21290	COG1309	transcriptional regulator
MTP02_RS21300	COG1946	Acyl-CoA thioesterase
MTP02_RS21345	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MTP02_RS21355	COG3960	tartronate-semialdehyde synthase activity
MTP02_RS21375	COG1472	Belongs to the glycosyl hydrolase 3 family
MTP02_RS21380	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MTP02_RS21425	COG3718	enzyme involved in inositol metabolism
MTP02_RS21430	COG3962	Belongs to the TPP enzyme family
MTP02_RS21445	COG1131	(ABC) transporter
MTP02_RS21480	COG3903	Transcriptional regulator
MTP02_RS21480	COG3629	intracellular signal transduction
MTP02_RS21590	COG1136	(ABC) transporter
MTP02_RS21610	COG0667	Aldo Keto reductase
MTP02_RS21615	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MTP02_RS21645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MTP02_RS21670	COG1486	melibiose metabolic process
MTP02_RS21680	COG0668	transmembrane transport
MTP02_RS21695	COG3525	Glycosyl hydrolase, family 20, catalytic domain
MTP02_RS21715	COG0583	DNA-binding transcription factor activity
MTP02_RS21745	COG4266	Belongs to the allantoicase family
MTP02_RS21780	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MTP02_RS21785	COG0076	glutamate decarboxylase activity
MTP02_RS21790	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MTP02_RS21795	COG1113	amino acid transport
MTP02_RS21800	COG1113	amino acid transport
MTP02_RS21805	COG1268	BioY protein
MTP02_RS21810	COG1113	amino acid transport
MTP02_RS21825	COG4552	Acetyltransferase involved in intracellular survival and related
MTP02_RS21860	COG0544	peptidyl-prolyl cis-trans isomerase activity
MTP02_RS21865	COG0740	serine-type endopeptidase activity
MTP02_RS21870	COG0740	serine-type endopeptidase activity
MTP02_RS21875	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MTP02_RS21885	COG0525	valine-tRNA ligase activity
MTP02_RS21890	COG0285	dihydrofolate synthase activity
MTP02_RS21900	COG0105	UTP biosynthetic process
MTP02_RS21905	COG1077	Cell shape determining protein MreB Mrl
MTP02_RS21925	COG0772	Belongs to the SEDS family
MTP02_RS21955	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MTP02_RS21960	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MTP02_RS21965	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MTP02_RS21985	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MTP02_RS21995	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MTP02_RS22015	COG0501	Belongs to the peptidase M48B family
MTP02_RS22030	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MTP02_RS22040	COG0799	negative regulation of ribosome biogenesis
MTP02_RS22045	COG0588	phosphoglycerate mutase activity
MTP02_RS22070	COG0495	leucyl-tRNA aminoacylation
MTP02_RS22080	COG1307	EDD domain protein, DegV family
MTP02_RS22085	COG1555	photosystem II stabilization
MTP02_RS22100	COG2353	YceI-like domain
MTP02_RS22115	COG0268	Binds directly to 16S ribosomal RNA
MTP02_RS22120	COG0481	GTPase activity
MTP02_RS22155	COG0484	heat shock protein binding
MTP02_RS22170	COG4946	Tricorn protease homolog
MTP02_RS22170	COG0793	Belongs to the peptidase S41A family
MTP02_RS22175	COG0537	adenosine 5'-monophosphoramidase activity
MTP02_RS22180	COG1234	tRNA 3'-trailer cleavage
MTP02_RS22200	COG2515	1-aminocyclopropane-1-carboxylate deaminase
MTP02_RS22205	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MTP02_RS22230	COG1486	melibiose metabolic process
MTP02_RS22235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MTP02_RS22255	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MTP02_RS22265	COG2315	Protein conserved in bacteria
MTP02_RS22275	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MTP02_RS22290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MTP02_RS22305	COG1381	Involved in DNA repair and RecF pathway recombination
MTP02_RS22310	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MTP02_RS22320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MTP02_RS22325	COG1121	(ABC) transporter
MTP02_RS22335	COG0423	glycine-tRNA ligase activity
MTP02_RS22405	COG0189	ligase activity
MTP02_RS22415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MTP02_RS22430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MTP02_RS22435	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
MTP02_RS22445	COG3467	pyridoxamine 5'-phosphate
MTP02_RS22475	COG1846	Transcriptional regulator
MTP02_RS22475	COG1940	carbohydrate kinase activity
MTP02_RS22485	COG0574	Belongs to the PEP-utilizing enzyme family
MTP02_RS22485	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MTP02_RS22500	COG1324	tolerance protein
MTP02_RS22510	COG0829	nickel cation binding
MTP02_RS22515	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MTP02_RS22520	COG0830	nickel cation binding
MTP02_RS22525	COG0804	urea catabolic process
MTP02_RS22530	COG0832	Belongs to the urease beta subunit family
MTP02_RS22540	COG0738	Major facilitator superfamily
MTP02_RS22545	COG1028	Short-chain dehydrogenase reductase Sdr
MTP02_RS22560	COG2226	methyltransferase
MTP02_RS22600	COG1070	Carbohydrate kinase
MTP02_RS22620	COG0358	DNA primase activity
MTP02_RS22630	COG3290	protein histidine kinase activity
MTP02_RS22635	COG4565	transcriptional regulatory protein
MTP02_RS22640	COG2851	Citrate transporter
MTP02_RS22650	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MTP02_RS22670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MTP02_RS22695	COG1028	Short-chain dehydrogenase reductase Sdr
MTP02_RS22710	COG2890	protein-(glutamine-N5) methyltransferase activity
MTP02_RS22725	COG1077	Cell shape determining protein MreB Mrl
MTP02_RS22750	COG2130	NADP-dependent
MTP02_RS22755	COG1764	response to oxidative stress
MTP02_RS22785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MTP02_RS22790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MTP02_RS22795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MTP02_RS22810	COG1741	Belongs to the pirin family
MTP02_RS22825	COG0789	Transcriptional regulator
MTP02_RS22830	COG0667	Aldo Keto reductase
MTP02_RS22845	COG2197	response regulator
MTP02_RS22850	COG4585	Histidine kinase
MTP02_RS22870	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MTP02_RS22915	COG1358	cellular component organization or biogenesis
MTP02_RS23035	COG3845	ABC transporter
MTP02_RS23050	COG1657	PFAM Prenyltransferase squalene oxidase
MTP02_RS23055	COG0438	transferase activity, transferring glycosyl groups
MTP02_RS23085	COG0477	Major facilitator Superfamily
MTP02_RS23090	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MTP02_RS23095	COG1960	acyl-CoA dehydrogenase activity
MTP02_RS23110	COG2197	response regulator
MTP02_RS23115	COG0346	lactoylglutathione lyase activity
MTP02_RS23120	COG4585	Histidine kinase
MTP02_RS23130	COG1131	(ABC) transporter
MTP02_RS23145	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MTP02_RS23160	COG0800	Aldolase
MTP02_RS23165	COG3022	response to hydroperoxide
MTP02_RS23205	COG1733	regulation of RNA biosynthetic process
MTP02_RS23225	COG2226	methyltransferase
MTP02_RS23230	COG0384	phenazine biosynthesis protein PhzF
MTP02_RS23255	COG0076	glutamate decarboxylase activity
MTP02_RS23265	COG2814	Major facilitator Superfamily
MTP02_RS23270	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MTP02_RS23280	COG1834	amidinotransferase
MTP02_RS23300	COG1120	ATPase activity
MTP02_RS23305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MTP02_RS23310	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MTP02_RS23355	COG1994	Peptidase M50
MTP02_RS23360	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MTP02_RS23375	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MTP02_RS23375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MTP02_RS23380	COG2132	Multicopper oxidase
MTP02_RS23400	COG0174	glutamine synthetase
MTP02_RS23425	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MTP02_RS23445	COG1228	amidohydrolase
MTP02_RS23460	COG1609	Transcriptional regulator
MTP02_RS23465	COG2182	Extracellular solute-binding protein
MTP02_RS23470	COG1175	transmembrane transport
MTP02_RS23475	COG0395	ABC-type sugar transport system, permease component
MTP02_RS23480	COG0366	Alpha amylase catalytic
MTP02_RS23505	COG1309	transcriptional regulator
MTP02_RS23530	COG0745	RESPONSE REGULATOR receiver
MTP02_RS23560	COG1012	belongs to the aldehyde dehydrogenase family
MTP02_RS23625	COG2326	polyphosphate kinase activity
MTP02_RS23635	COG2376	Dihydroxyacetone kinase
MTP02_RS23645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MTP02_RS23685	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MTP02_RS23690	COG0321	lipoyl(octanoyl) transferase activity
MTP02_RS23700	COG0456	acetyltransferase
MTP02_RS23725	COG4221	oxidoreductase activity
MTP02_RS23740	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MTP02_RS23750	COG0508	dehydrogenase complex catalyzes the overall conversion of
MTP02_RS23755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MTP02_RS23760	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MTP02_RS23765	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MTP02_RS23775	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MTP02_RS23820	COG2197	response regulator
MTP02_RS23825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MTP02_RS23830	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MTP02_RS23855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MTP02_RS23860	COG1104	cysteine desulfurase activity
MTP02_RS23865	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MTP02_RS23870	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MTP02_RS23880	COG1376	ErfK ybiS ycfS ynhG family protein
MTP02_RS23890	COG1845	cytochrome c oxidase, subunit III
MTP02_RS23895	COG2010	Cytochrome c
MTP02_RS23900	COG0723	plastoquinol--plastocyanin reductase activity
MTP02_RS23905	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MTP02_RS23910	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MTP02_RS23915	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MTP02_RS23920	COG1929	Belongs to the glycerate kinase type-1 family
MTP02_RS23930	COG0745	RESPONSE REGULATOR receiver
MTP02_RS23935	COG5002	protein histidine kinase activity
MTP02_RS23950	COG0705	Rhomboid family
MTP02_RS23985	COG0438	transferase activity, transferring glycosyl groups
MTP02_RS24005	COG0003	Pfam Anion-transporting ATPase
MTP02_RS24015	COG1940	carbohydrate kinase activity
MTP02_RS24040	COG4585	Histidine kinase
MTP02_RS24045	COG2197	response regulator
MTP02_RS24050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MTP02_RS24060	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
MTP02_RS24065	COG0243	molybdopterin cofactor binding
MTP02_RS24070	COG2193	ferroxidase activity
MTP02_RS24075	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MTP02_RS24080	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MTP02_RS24085	COG0515	serine threonine protein kinase
MTP02_RS24085	COG2815	serine threonine protein kinase
MTP02_RS24090	COG2022	thiamine diphosphate biosynthetic process
MTP02_RS24100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MTP02_RS24100	COG2022	thiamine diphosphate biosynthetic process
MTP02_RS24115	COG0352	thiamine-phosphate diphosphorylase activity
MTP02_RS24135	COG1309	transcriptional regulator
MTP02_RS24145	COG1121	(ABC) transporter
MTP02_RS24150	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MTP02_RS24170	COG0714	Associated with various cellular activities
MTP02_RS24180	COG0275	rRNA processing
MTP02_RS24195	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MTP02_RS24205	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MTP02_RS24210	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MTP02_RS24220	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MTP02_RS24225	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MTP02_RS24230	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MTP02_RS24235	COG1496	oxidoreductase activity
MTP02_RS24245	COG1799	cell septum assembly
MTP02_RS24255	COG3599	regulation of cell shape
MTP02_RS24260	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MTP02_RS24270	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MTP02_RS24280	COG2153	protein acetylation
MTP02_RS24295	COG0515	serine threonine protein kinase
MTP02_RS24315	COG0587	DNA-directed DNA polymerase activity
MTP02_RS24325	COG1432	Conserved Protein
MTP02_RS24345	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MTP02_RS24365	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MTP02_RS24370	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MTP02_RS24375	COG0131	Imidazoleglycerol-phosphate dehydratase
MTP02_RS24385	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MTP02_RS24390	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MTP02_RS24400	COG0107	imidazoleglycerol-phosphate synthase activity
MTP02_RS24405	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MTP02_RS24415	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MTP02_RS24445	COG0134	indole-3-glycerol-phosphate synthase activity
MTP02_RS24450	COG0133	tryptophan synthase activity
MTP02_RS24455	COG0159	tryptophan synthase activity
MTP02_RS24465	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MTP02_RS24475	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MTP02_RS24480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MTP02_RS24510	COG0067	glutamate synthase
MTP02_RS24510	COG0069	glutamate synthase activity
MTP02_RS24510	COG0070	glutamate synthase
MTP02_RS24525	COG1278	Cold shock
MTP02_RS24530	COG0513	Belongs to the DEAD box helicase family
MTP02_RS24540	COG1605	Chorismate mutase
MTP02_RS24540	COG0287	Prephenate dehydrogenase
MTP02_RS24575	COG0737	Belongs to the 5'-nucleotidase family
MTP02_RS24615	COG0559	Belongs to the binding-protein-dependent transport system permease family
MTP02_RS24625	COG2746	aminoglycoside 3-N-acetyltransferase activity
MTP02_RS24630	COG2050	protein possibly involved in aromatic compounds catabolism
MTP02_RS24650	COG1643	Atp-dependent helicase
MTP02_RS24655	COG2226	methyltransferase
MTP02_RS24675	COG0237	dephospho-CoA kinase activity
MTP02_RS24700	COG1288	antiporter activity
MTP02_RS24750	COG0477	Major facilitator Superfamily
MTP02_RS24760	COG0584	glycerophosphoryl diester phosphodiesterase
MTP02_RS24770	COG0556	nucleotide-excision repair
MTP02_RS24790	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MTP02_RS24795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MTP02_RS24805	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MTP02_RS24825	COG1660	Displays ATPase and GTPase activities
MTP02_RS24835	COG1481	regulation of sporulation
MTP02_RS24840	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MTP02_RS24845	COG0126	phosphoglycerate kinase activity
MTP02_RS24850	COG0149	triose-phosphate isomerase activity
MTP02_RS24855	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MTP02_RS24865	COG0166	Belongs to the GPI family
MTP02_RS24870	COG0363	glucosamine-6-phosphate deaminase activity
MTP02_RS24885	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MTP02_RS24890	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MTP02_RS24895	COG0109	protoheme IX farnesyltransferase activity
MTP02_RS24920	COG1131	(ABC) transporter
MTP02_RS24935	COG0719	Fe-S assembly protein
MTP02_RS24945	COG0396	ATPase activity
MTP02_RS24950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MTP02_RS24955	COG0822	iron-sulfur transferase activity
MTP02_RS24965	COG2171	N-acyltransferase activity
MTP02_RS25000	COG2197	response regulator
MTP02_RS25005	COG4585	Histidine kinase
MTP02_RS25035	COG1902	pentaerythritol trinitrate reductase activity
MTP02_RS25040	COG5285	phytanoyl-CoA dioxygenase
MTP02_RS25045	COG1917	Cupin 2, conserved barrel domain protein
MTP02_RS25055	COG0456	acetyltransferase
MTP02_RS25060	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MTP02_RS25090	COG1797	cobyrinic acid a,c-diamide synthase activity
MTP02_RS25105	COG1492	cobalamin metabolic process
MTP02_RS25125	COG0235	Class ii aldolase
MTP02_RS25145	COG0488	(ABC) transporter
MTP02_RS25200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MTP02_RS25220	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MTP02_RS25235	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MTP02_RS25240	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MTP02_RS25250	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
MTP02_RS25270	COG2261	transglycosylase associated protein
MTP02_RS25275	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MTP02_RS25285	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MTP02_RS25295	COG2186	Transcriptional regulator
MTP02_RS25300	COG2807	transmembrane transport
MTP02_RS25315	COG3830	Belongs to the UPF0237 family
MTP02_RS25315	COG0560	Phosphoserine phosphatase
MTP02_RS25320	COG0842	Transport permease protein
MTP02_RS25320	COG1716	ATPase activity
MTP02_RS25320	COG1131	(ABC) transporter
MTP02_RS25330	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MTP02_RS25345	COG2197	response regulator
MTP02_RS25360	COG1119	ATPase activity
MTP02_RS25380	COG1881	PFAM PEBP family protein
MTP02_RS25390	COG2094	Belongs to the DNA glycosylase MPG family
MTP02_RS25425	COG0647	UMP catabolic process
MTP02_RS25445	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MTP02_RS25450	COG0497	DNA recombination
MTP02_RS25465	COG0297	glycogen (starch) synthase activity
MTP02_RS25470	COG3896	Chloramphenicol phosphotransferase-like protein
MTP02_RS25480	COG3387	PFAM Glycoside hydrolase 15-related
MTP02_RS25485	COG0504	CTP synthase activity
MTP02_RS25490	COG0494	nUDIX hydrolase
MTP02_RS25500	COG0686	Belongs to the AlaDH PNT family
MTP02_RS25515	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MTP02_RS25520	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MTP02_RS25525	COG1187	pseudouridine synthase activity
MTP02_RS25535	COG1397	ADP-ribosylglycohydrolase
MTP02_RS25540	COG3541	Predicted nucleotidyltransferase
MTP02_RS25555	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MTP02_RS25565	COG1160	GTP binding
MTP02_RS25585	COG0438	transferase activity, transferring glycosyl groups
MTP02_RS25605	COG0671	phosphoesterase, PA-phosphatase related
MTP02_RS25615	COG0477	Major facilitator Superfamily
MTP02_RS25620	COG1799	cell septum assembly
MTP02_RS25635	COG0765	amino acid transport
MTP02_RS25645	COG0765	amino acid transport
MTP02_RS25655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MTP02_RS25660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MTP02_RS25680	COG0330	HflC and HflK could
MTP02_RS25695	COG0587	DNA-directed DNA polymerase activity
MTP02_RS25700	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MTP02_RS25765	COG1216	Glycosyl transferase, family 2
MTP02_RS25790	COG2755	lipolytic protein G-D-S-L family
MTP02_RS25810	COG3973	AAA domain
MTP02_RS25815	COG2188	Transcriptional regulator
MTP02_RS25820	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
MTP02_RS25845	COG1309	transcriptional regulator
MTP02_RS25885	COG3876	Protein conserved in bacteria
MTP02_RS25895	COG0488	(ABC) transporter
MTP02_RS25910	COG0318	PFAM AMP-dependent synthetase and ligase
MTP02_RS25920	COG1960	acyl-CoA dehydrogenase activity
MTP02_RS25940	COG2149	membrane
MTP02_RS25945	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
MTP02_RS25985	COG3265	gluconokinase activity
MTP02_RS25995	COG3012	SEC-C Motif Domain Protein
MTP02_RS26000	COG3189	MarR family transcriptional regulator
MTP02_RS26010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MTP02_RS26040	COG0667	Aldo Keto reductase
MTP02_RS26045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MTP02_RS26055	COG0598	Magnesium transport protein CorA
MTP02_RS26075	COG0215	cysteine-tRNA ligase activity
MTP02_RS26090	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MTP02_RS26095	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MTP02_RS26100	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MTP02_RS26110	COG1410	methionine synthase
MTP02_RS26110	COG0646	methionine synthase
MTP02_RS26120	COG0747	negative chemotaxis
MTP02_RS26125	COG2197	response regulator
MTP02_RS26135	COG0517	IMP dehydrogenase activity
MTP02_RS26135	COG1994	Peptidase M50
MTP02_RS26155	COG1222	aaa ATPase
MTP02_RS26160	COG4122	O-methyltransferase activity
MTP02_RS26170	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MTP02_RS26175	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MTP02_RS26190	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MTP02_RS26225	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MTP02_RS26230	COG0805	protein transport
MTP02_RS26245	COG2124	cytochrome p450
MTP02_RS26275	COG0564	pseudouridine synthase activity
MTP02_RS26285	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MTP02_RS26295	COG1595	DNA-templated transcription, initiation
MTP02_RS26305	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MTP02_RS26310	COG0517	IMP dehydrogenase activity
MTP02_RS26310	COG4175	Glycine betaine
MTP02_RS26335	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MTP02_RS26340	COG0531	amino acid
MTP02_RS26345	COG2186	Transcriptional regulator
MTP02_RS26350	COG0174	glutamine synthetase
MTP02_RS26355	COG1012	belongs to the aldehyde dehydrogenase family
MTP02_RS26390	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MTP02_RS26400	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MTP02_RS26405	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MTP02_RS26410	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MTP02_RS26415	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MTP02_RS26425	COG5002	protein histidine kinase activity
MTP02_RS26430	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MTP02_RS26435	COG0072	phenylalanine-tRNA ligase activity
MTP02_RS26435	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MTP02_RS26465	COG0697	spore germination
MTP02_RS26470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MTP02_RS26490	COG0477	Major facilitator Superfamily
MTP02_RS26510	COG2838	Isocitrate dehydrogenase
MTP02_RS26525	COG1309	transcriptional regulator
MTP02_RS26540	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MTP02_RS26580	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MTP02_RS26585	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MTP02_RS26590	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MTP02_RS26595	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MTP02_RS26600	COG1438	arginine binding
MTP02_RS26605	COG4585	Histidine kinase
MTP02_RS26610	COG2197	response regulator
MTP02_RS26620	COG2409	Drug exporters of the RND superfamily
MTP02_RS26625	COG0385	Bile acid
MTP02_RS26635	COG0165	Argininosuccinate lyase
MTP02_RS26660	COG0477	Major facilitator Superfamily
MTP02_RS26665	COG0204	Acyl-transferase
MTP02_RS26665	COG0318	PFAM AMP-dependent synthetase and ligase
MTP02_RS26670	COG0584	glycerophosphoryl diester phosphodiesterase
MTP02_RS26695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MTP02_RS26700	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MTP02_RS26705	COG2011	ABC-type metal ion transport system permease component
MTP02_RS26710	COG1464	Belongs to the NlpA lipoprotein family
MTP02_RS26715	COG1464	Belongs to the NlpA lipoprotein family
MTP02_RS26730	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MTP02_RS26735	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MTP02_RS26735	COG1648	precorrin-2 dehydrogenase activity
MTP02_RS26800	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MTP02_RS26810	COG0456	acetyltransferase
MTP02_RS26870	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MTP02_RS26890	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MTP02_RS26895	COG1560	Kdo2-lipid A biosynthetic process
MTP02_RS26900	COG0438	transferase activity, transferring glycosyl groups
MTP02_RS26910	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MTP02_RS26915	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MTP02_RS26920	COG0217	transcriptional regulatory protein
MTP02_RS26925	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MTP02_RS26930	COG0632	four-way junction helicase activity
MTP02_RS26935	COG2255	four-way junction helicase activity
MTP02_RS26945	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MTP02_RS26950	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MTP02_RS26955	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MTP02_RS26960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MTP02_RS26970	COG1196	nuclear chromosome segregation
MTP02_RS26975	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MTP02_RS26985	COG0124	histidyl-tRNA synthetase
MTP02_RS27000	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MTP02_RS27015	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MTP02_RS27020	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MTP02_RS27025	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MTP02_RS27030	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MTP02_RS27035	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MTP02_RS27040	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MTP02_RS27045	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MTP02_RS27055	COG0006	proline dipeptidase activity
MTP02_RS27060	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MTP02_RS27065	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MTP02_RS27075	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MTP02_RS27080	COG0540	Belongs to the ATCase OTCase family
MTP02_RS27085	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MTP02_RS27095	COG0505	Belongs to the CarA family
MTP02_RS27100	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MTP02_RS27105	COG0167	dihydroorotate dehydrogenase activity
MTP02_RS27110	COG0284	orotidine-5'-phosphate decarboxylase activity
MTP02_RS27125	COG1758	RNA polymerase activity
MTP02_RS27135	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MTP02_RS27165	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MTP02_RS27180	COG2318	DinB family
MTP02_RS27185	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MTP02_RS27190	COG2390	Transcriptional regulator
MTP02_RS27230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MTP02_RS27250	COG0697	spore germination
MTP02_RS27255	COG2233	PERMEase
MTP02_RS27265	COG0738	Major facilitator superfamily
MTP02_RS27270	COG1940	carbohydrate kinase activity
MTP02_RS27270	COG1846	Transcriptional regulator
MTP02_RS27275	COG1090	epimerase
MTP02_RS27290	COG3201	nicotinamide mononucleotide transporter
MTP02_RS27295	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MTP02_RS27295	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MTP02_RS27300	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MTP02_RS27305	COG0140	phosphoribosyl-ATP diphosphatase activity
MTP02_RS27310	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MTP02_RS27340	COG1960	acyl-CoA dehydrogenase activity
MTP02_RS27360	COG0463	Glycosyl transferase, family 2
MTP02_RS27375	COG2270	Major facilitator Superfamily
MTP02_RS27385	COG2364	Membrane
MTP02_RS27390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MTP02_RS27475	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
MTP02_RS27495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MTP02_RS27505	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MTP02_RS27535	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MTP02_RS27555	COG1716	ATPase activity
MTP02_RS27575	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MTP02_RS27585	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MTP02_RS27585	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MTP02_RS27625	COG0539	negative regulation of cytoplasmic translation
MTP02_RS27645	COG0697	spore germination
MTP02_RS27660	COG0697	spore germination
MTP02_RS27680	COG4251	negative regulation of phosphorylation
MTP02_RS27690	COG0154	amidase activity
MTP02_RS27730	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MTP02_RS27755	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MTP02_RS27775	COG1982	Orn Lys Arg decarboxylase major
MTP02_RS27785	COG1968	undecaprenyl-diphosphatase activity
MTP02_RS27805	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MTP02_RS27870	COG0110	maltose O-acetyltransferase activity
MTP02_RS27880	COG1832	CoA-binding protein
MTP02_RS27885	COG1739	Uncharacterized protein family UPF0029
MTP02_RS27905	COG1595	DNA-templated transcription, initiation
MTP02_RS27925	COG0420	3'-5' exonuclease activity
MTP02_RS27930	COG0419	ATPase involved in DNA repair
MTP02_RS27935	COG1522	sequence-specific DNA binding
MTP02_RS27945	COG1028	Short-chain dehydrogenase reductase Sdr
MTP02_RS27960	COG0626	cystathionine gamma-synthase activity
MTP02_RS27985	COG2188	Transcriptional regulator
MTP02_RS27990	COG1940	carbohydrate kinase activity
MTP02_RS28005	COG3663	DNA glycosylase
MTP02_RS28010	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MTP02_RS28030	COG0456	acetyltransferase
MTP02_RS28035	COG0488	(ABC) transporter
MTP02_RS28040	COG0488	(ABC) transporter
MTP02_RS28050	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MTP02_RS28055	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MTP02_RS28060	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MTP02_RS28085	COG0791	NLP P60 protein
MTP02_RS28090	COG0740	serine-type endopeptidase activity
MTP02_RS28100	COG0831	urea catabolic process
MTP02_RS28105	COG0832	Belongs to the urease beta subunit family
MTP02_RS28110	COG0804	urea catabolic process
MTP02_RS28120	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MTP02_RS28125	COG0829	nickel cation binding
MTP02_RS28130	COG4552	Acetyltransferase involved in intracellular survival and related
MTP02_RS28135	COG0204	Acyl-transferase
MTP02_RS28165	COG1132	(ABC) transporter
MTP02_RS28180	COG2175	clavaminate synthase activity
MTP02_RS28190	COG0435	Glutathione S-transferase
MTP02_RS28195	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MTP02_RS28195	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MTP02_RS28205	COG2770	Histidine kinase
MTP02_RS28205	COG2208	phosphoserine phosphatase activity
MTP02_RS28220	COG0205	6-phosphofructokinase activity
MTP02_RS28225	COG3442	glutamine amidotransferase
MTP02_RS28235	COG0242	peptide deformylase activity
MTP02_RS28245	COG1960	acyl-CoA dehydrogenase activity
MTP02_RS28265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MTP02_RS28290	COG1175	transmembrane transport
MTP02_RS28295	COG0395	ABC-type sugar transport system, permease component
MTP02_RS28300	COG2723	6-phospho-beta-galactosidase activity
MTP02_RS28305	COG0501	Belongs to the peptidase M48B family
MTP02_RS28350	COG4251	negative regulation of phosphorylation
MTP02_RS28355	COG0784	Response regulator, receiver
MTP02_RS28375	COG0656	L-ascorbic acid biosynthetic process
MTP02_RS28385	COG1595	DNA-templated transcription, initiation
MTP02_RS28395	COG1132	(ABC) transporter
MTP02_RS28415	COG0697	spore germination
MTP02_RS28420	COG0546	phosphoglycolate phosphatase activity
MTP02_RS28425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MTP02_RS28435	COG2313	pseudouridylate synthase activity
MTP02_RS28440	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MTP02_RS28475	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MTP02_RS28480	COG3279	Response regulator of the LytR AlgR family
MTP02_RS28490	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MTP02_RS28495	COG3275	phosphorelay sensor kinase activity
MTP02_RS28570	COG1053	succinate dehydrogenase
MTP02_RS28575	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MTP02_RS28580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MTP02_RS28590	COG3360	Dodecin
MTP02_RS28595	COG2182	Extracellular solute-binding protein
MTP02_RS28600	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
MTP02_RS28605	COG0121	glutamine amidotransferase
MTP02_RS28610	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MTP02_RS28630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MTP02_RS28635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MTP02_RS28655	COG2837	iron assimilation
MTP02_RS28665	COG1796	DNA polymerase
MTP02_RS28665	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MTP02_RS28670	COG0142	geranyltranstransferase activity
MTP02_RS28695	COG3293	Transposase
MTP02_RS28710	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
MTP02_RS28735	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MTP02_RS28745	COG0254	rRNA binding
MTP02_RS28750	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MTP02_RS28755	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MTP02_RS28760	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MTP02_RS28790	COG0477	Major facilitator Superfamily
MTP02_RS28820	COG3119	arylsulfatase activity
MTP02_RS28835	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MTP02_RS28840	COG4948	Mandelate Racemase Muconate Lactonizing
MTP02_RS28910	COG0464	growth
MTP02_RS28930	COG3655	Transcriptional regulator
MTP02_RS28950	COG0803	Belongs to the bacterial solute-binding protein 9 family
MTP02_RS28960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MTP02_RS28965	COG1121	(ABC) transporter
MTP02_RS28970	COG0590	tRNA wobble adenosine to inosine editing
MTP02_RS28975	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MTP02_RS29005	COG2201	protein-glutamate methylesterase activity
MTP02_RS29010	COG0300	oxidoreductase activity
MTP02_RS29020	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MTP02_RS29055	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MTP02_RS29060	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MTP02_RS29065	COG1984	allophanate hydrolase subunit 2
MTP02_RS29100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MTP02_RS29105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MTP02_RS29110	COG1120	ATPase activity
MTP02_RS29140	COG1132	(ABC) transporter
MTP02_RS29145	COG1132	(ABC) transporter
MTP02_RS29150	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MTP02_RS29160	COG0110	maltose O-acetyltransferase activity
MTP02_RS29175	COG0242	peptide deformylase activity
MTP02_RS29195	COG1349	DNA-binding transcription factor activity
MTP02_RS29210	COG3395	kinase activity
MTP02_RS29215	COG0235	Class ii aldolase
MTP02_RS29255	COG4608	Belongs to the ABC transporter superfamily
MTP02_RS29260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MTP02_RS29275	COG1028	Short-chain dehydrogenase reductase Sdr
MTP02_RS29295	COG1174	glycine betaine transport
MTP02_RS29300	COG1174	glycine betaine transport
MTP02_RS29310	COG0517	IMP dehydrogenase activity
MTP02_RS29310	COG1125	glycine betaine transport
MTP02_RS29335	COG1960	acyl-CoA dehydrogenase activity
MTP02_RS29340	COG1960	acyl-CoA dehydrogenase activity
MTP02_RS29350	COG0601	transmembrane transport
MTP02_RS29355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MTP02_RS29360	COG0444	Belongs to the ABC transporter superfamily
MTP02_RS29365	COG1124	(ABC) transporter
MTP02_RS29375	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
MTP02_RS29380	COG2318	DinB family
MTP02_RS29405	COG0277	FAD linked oxidase domain protein
MTP02_RS29410	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MTP02_RS29415	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MTP02_RS29425	COG2271	Major facilitator Superfamily
MTP02_RS29475	COG1028	Short-chain dehydrogenase reductase Sdr
MTP02_RS29485	COG0142	geranyltranstransferase activity
MTP02_RS29545	COG0604	alcohol dehydrogenase
MTP02_RS29545	COG3321	synthase
MTP02_RS29565	COG3321	synthase
MTP02_RS29565	COG0604	alcohol dehydrogenase
MTP02_RS29580	COG0604	alcohol dehydrogenase
MTP02_RS29580	COG3321	synthase
MTP02_RS29600	COG2124	cytochrome p450
MTP02_RS29605	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MTP02_RS29645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MTP02_RS29655	COG1129	ABC transporter
MTP02_RS29685	COG3483	tryptophan 2,3-dioxygenase activity
MTP02_RS29690	COG1028	Short-chain dehydrogenase reductase Sdr
MTP02_RS29695	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MTP02_RS29700	COG2151	metal-sulfur cluster biosynthetic enzyme
MTP02_RS29705	COG3396	Phenylacetate-CoA oxygenase
MTP02_RS29715	COG3396	Phenylacetate-CoA oxygenase
MTP02_RS29730	COG0604	alcohol dehydrogenase
MTP02_RS29740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MTP02_RS29790	COG0515	serine threonine protein kinase
MTP02_RS29825	COG1404	Belongs to the peptidase S8 family
MTP02_RS29895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MTP02_RS29895	COG0300	oxidoreductase activity
MTP02_RS29895	COG3321	synthase
MTP02_RS29895	COG4221	oxidoreductase activity
MTP02_RS29910	COG4335	DNA alkylation repair
MTP02_RS29945	COG0477	Major facilitator Superfamily
MTP02_RS29975	COG3246	L-lysine catabolic process to acetate
MTP02_RS29980	COG1250	3-hydroxyacyl-CoA dehydrogenase