locus-tag	class	description
I8755_RS00030	COG2815	serine threonine protein kinase
I8755_RS00030	COG0515	serine threonine protein kinase
I8755_RS00200	COG1595	DNA-templated transcription, initiation
I8755_RS00275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8755_RS00280	COG1309	transcriptional regulator
I8755_RS00385	COG2175	clavaminate synthase activity
I8755_RS00390	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I8755_RS00445	COG2197	response regulator
I8755_RS00455	COG3959	Transketolase, thiamine diphosphate binding domain
I8755_RS00460	COG3958	Transketolase
I8755_RS00470	COG3251	PFAM MbtH domain protein
I8755_RS00495	COG3321	synthase
I8755_RS00495	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS00495	COG0604	alcohol dehydrogenase
I8755_RS00515	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS00525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I8755_RS00535	COG0318	PFAM AMP-dependent synthetase and ligase
I8755_RS00540	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS00565	COG3903	Transcriptional regulator
I8755_RS00565	COG3629	intracellular signal transduction
I8755_RS00570	COG2197	response regulator
I8755_RS00585	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I8755_RS00600	COG0667	Aldo Keto reductase
I8755_RS00635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8755_RS00645	COG2070	2-Nitropropane dioxygenase
I8755_RS00685	COG0702	epimerase
I8755_RS00690	COG2124	cytochrome p450
I8755_RS00730	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I8755_RS00740	COG1309	transcriptional regulator
I8755_RS00745	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS00775	COG0667	Aldo Keto reductase
I8755_RS00785	COG1309	transcriptional regulator
I8755_RS00790	COG0596	Alpha beta hydrolase
I8755_RS00820	COG0277	FAD linked oxidase domain protein
I8755_RS00830	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I8755_RS00840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I8755_RS00840	COG2022	thiamine diphosphate biosynthetic process
I8755_RS00855	COG1073	alpha beta
I8755_RS00880	COG1309	transcriptional regulator
I8755_RS00885	COG0667	Aldo Keto reductase
I8755_RS00915	COG0702	epimerase
I8755_RS00950	COG3397	chitin binding
I8755_RS00960	COG5297	Belongs to the glycosyl hydrolase family 6
I8755_RS00975	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I8755_RS01070	COG3693	PFAM glycoside hydrolase, family 10
I8755_RS01080	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS01125	COG0393	Putative heavy-metal-binding
I8755_RS01140	COG3903	Transcriptional regulator
I8755_RS01140	COG3629	intracellular signal transduction
I8755_RS01145	COG2267	carboxylic ester hydrolase activity
I8755_RS01150	COG0596	Alpha beta hydrolase
I8755_RS01160	COG2197	response regulator
I8755_RS01165	COG4585	Histidine kinase
I8755_RS01230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8755_RS01250	COG0583	DNA-binding transcription factor activity
I8755_RS01255	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I8755_RS01295	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I8755_RS01310	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I8755_RS01320	COG0590	tRNA wobble adenosine to inosine editing
I8755_RS01335	COG0583	DNA-binding transcription factor activity
I8755_RS01350	COG1136	(ABC) transporter
I8755_RS01390	COG2814	Major facilitator Superfamily
I8755_RS01400	COG0456	acetyltransferase
I8755_RS01410	COG3409	Peptidoglycan-binding domain 1 protein
I8755_RS01420	COG1116	anion transmembrane transporter activity
I8755_RS01425	COG1686	Belongs to the peptidase S11 family
I8755_RS01435	COG0745	RESPONSE REGULATOR receiver
I8755_RS01440	COG2205	protein histidine kinase activity
I8755_RS01500	COG3251	PFAM MbtH domain protein
I8755_RS01520	COG2124	cytochrome p450
I8755_RS01535	COG1032	radical SAM domain protein
I8755_RS01575	COG0142	geranyltranstransferase activity
I8755_RS01615	COG1309	transcriptional regulator
I8755_RS01655	COG0789	Transcriptional regulator
I8755_RS01690	COG0640	Transcriptional regulator
I8755_RS01700	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS01705	COG1959	2 iron, 2 sulfur cluster binding
I8755_RS01710	COG1131	(ABC) transporter
I8755_RS01720	COG0745	RESPONSE REGULATOR receiver
I8755_RS01725	COG2205	protein histidine kinase activity
I8755_RS01780	COG4977	sequence-specific DNA binding
I8755_RS01785	COG0531	amino acid
I8755_RS01800	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I8755_RS01860	COG0477	Major facilitator Superfamily
I8755_RS01865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8755_RS01895	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I8755_RS01915	COG1755	Isoprenylcysteine carboxyl methyltransferase
I8755_RS01920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I8755_RS01925	COG0402	S-adenosylhomocysteine deaminase activity
I8755_RS01930	COG0477	Major facilitator Superfamily
I8755_RS01980	COG2197	response regulator
I8755_RS01985	COG4585	Histidine kinase
I8755_RS02035	COG4191	Histidine kinase
I8755_RS02065	COG1733	regulation of RNA biosynthetic process
I8755_RS02070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I8755_RS02075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8755_RS02080	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I8755_RS02165	COG2267	carboxylic ester hydrolase activity
I8755_RS02175	COG0076	glutamate decarboxylase activity
I8755_RS02195	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS02195	COG0604	alcohol dehydrogenase
I8755_RS02195	COG3321	synthase
I8755_RS02225	COG3977	Valine--pyruvate aminotransferase
I8755_RS02240	COG2124	cytochrome p450
I8755_RS02300	COG1309	transcriptional regulator
I8755_RS02305	COG0318	PFAM AMP-dependent synthetase and ligase
I8755_RS02310	COG1960	acyl-CoA dehydrogenase activity
I8755_RS02315	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I8755_RS02340	COG0640	Transcriptional regulator
I8755_RS02355	COG0596	Alpha beta hydrolase
I8755_RS02405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I8755_RS02415	COG0318	PFAM AMP-dependent synthetase and ligase
I8755_RS02520	COG2130	NADP-dependent
I8755_RS02535	COG3483	tryptophan 2,3-dioxygenase activity
I8755_RS02545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I8755_RS02560	COG2318	DinB family
I8755_RS02570	COG3226	Transcriptional regulator
I8755_RS02580	COG0738	Major facilitator superfamily
I8755_RS02590	COG2197	response regulator
I8755_RS02595	COG4552	Acetyltransferase involved in intracellular survival and related
I8755_RS02600	COG0596	Alpha beta hydrolase
I8755_RS02605	COG2226	methyltransferase
I8755_RS02620	COG2050	protein possibly involved in aromatic compounds catabolism
I8755_RS02630	COG2391	methyltransferase activity
I8755_RS02645	COG0832	Belongs to the urease beta subunit family
I8755_RS02645	COG0831	urea catabolic process
I8755_RS02650	COG0804	urea catabolic process
I8755_RS02660	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I8755_RS02665	COG0829	nickel cation binding
I8755_RS02680	COG1609	Transcriptional regulator
I8755_RS02685	COG1472	Belongs to the glycosyl hydrolase 3 family
I8755_RS02710	COG2226	methyltransferase
I8755_RS02720	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I8755_RS02745	COG1595	DNA-templated transcription, initiation
I8755_RS02750	COG0789	Transcriptional regulator
I8755_RS02755	COG0659	secondary active sulfate transmembrane transporter activity
I8755_RS02760	COG2072	flavoprotein involved in K transport
I8755_RS02765	COG0798	PFAM Bile acid sodium symporter
I8755_RS02775	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I8755_RS02800	COG0714	Associated with various cellular activities
I8755_RS02825	COG0154	amidase activity
I8755_RS02835	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I8755_RS02850	COG0596	Alpha beta hydrolase
I8755_RS02870	COG2186	Transcriptional regulator
I8755_RS02905	COG2197	response regulator
I8755_RS02935	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I8755_RS02995	COG2072	flavoprotein involved in K transport
I8755_RS03000	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS03025	COG0488	(ABC) transporter
I8755_RS03030	COG0110	maltose O-acetyltransferase activity
I8755_RS03045	COG3629	intracellular signal transduction
I8755_RS03045	COG3903	Transcriptional regulator
I8755_RS03050	COG0574	Belongs to the PEP-utilizing enzyme family
I8755_RS03050	COG3848	Pyruvate phosphate dikinase
I8755_RS03055	COG1335	isochorismatase
I8755_RS03060	COG1120	ATPase activity
I8755_RS03065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8755_RS03160	COG0583	DNA-binding transcription factor activity
I8755_RS03170	COG2186	Transcriptional regulator
I8755_RS03180	COG0318	PFAM AMP-dependent synthetase and ligase
I8755_RS03185	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I8755_RS03185	COG0825	malonyl-CoA metabolic process
I8755_RS03195	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I8755_RS03200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8755_RS03205	COG3629	intracellular signal transduction
I8755_RS03265	COG2124	cytochrome p450
I8755_RS03285	COG1051	belongs to the nudix hydrolase family
I8755_RS03310	COG1309	transcriptional regulator
I8755_RS03340	COG0366	Alpha amylase catalytic
I8755_RS03360	COG0151	Belongs to the GarS family
I8755_RS03380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I8755_RS03420	COG3591	Belongs to the peptidase S1B family
I8755_RS03460	COG2197	response regulator
I8755_RS03470	COG4106	trans-aconitate 2-methyltransferase activity
I8755_RS03485	COG0475	glutathione-regulated potassium exporter activity
I8755_RS03520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8755_RS03530	COG1595	DNA-templated transcription, initiation
I8755_RS03550	COG0346	lactoylglutathione lyase activity
I8755_RS03555	COG0640	Transcriptional regulator
I8755_RS03585	COG1554	hydrolase, family 65, central catalytic
I8755_RS03600	COG0488	(ABC) transporter
I8755_RS03625	COG0596	Alpha beta hydrolase
I8755_RS03630	COG3903	Transcriptional regulator
I8755_RS03630	COG3629	intracellular signal transduction
I8755_RS03695	COG0006	proline dipeptidase activity
I8755_RS03715	COG0513	Belongs to the DEAD box helicase family
I8755_RS03720	COG0477	Major facilitator Superfamily
I8755_RS03770	COG2124	cytochrome p450
I8755_RS03775	COG4566	intracellular signal transduction
I8755_RS03780	COG0667	Aldo Keto reductase
I8755_RS03800	COG1132	(ABC) transporter
I8755_RS03840	COG0667	Aldo Keto reductase
I8755_RS03850	COG4251	negative regulation of phosphorylation
I8755_RS03855	COG0784	Response regulator, receiver
I8755_RS03860	COG1349	DNA-binding transcription factor activity
I8755_RS03880	COG0395	ABC-type sugar transport system, permease component
I8755_RS03885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I8755_RS03910	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I8755_RS03915	COG1120	ATPase activity
I8755_RS03920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I8755_RS03930	COG1295	ribonuclease BN
I8755_RS03940	COG4106	trans-aconitate 2-methyltransferase activity
I8755_RS03960	COG0475	glutathione-regulated potassium exporter activity
I8755_RS03970	COG3973	AAA domain
I8755_RS03980	COG0655	NAD(P)H dehydrogenase (quinone) activity
I8755_RS03995	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I8755_RS04005	COG0789	Transcriptional regulator
I8755_RS04100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8755_RS04100	COG1263	PTS System
I8755_RS04105	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I8755_RS04160	COG3896	Chloramphenicol phosphotransferase-like protein
I8755_RS04190	COG1122	ATPase activity
I8755_RS04195	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I8755_RS04200	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
I8755_RS04230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8755_RS04255	COG0142	geranyltranstransferase activity
I8755_RS04275	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I8755_RS04290	COG2207	Transcriptional regulator
I8755_RS04290	COG3708	Transcriptional regulator
I8755_RS04315	COG2318	DinB family
I8755_RS04335	COG0009	L-threonylcarbamoyladenylate synthase
I8755_RS04355	COG1295	ribonuclease BN
I8755_RS04390	COG0693	protein deglycase activity
I8755_RS04470	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I8755_RS04485	COG2340	Cysteine-rich secretory protein family
I8755_RS04495	COG0739	heme binding
I8755_RS04515	COG1309	transcriptional regulator
I8755_RS04520	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I8755_RS04535	COG2755	lipolytic protein G-D-S-L family
I8755_RS04560	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I8755_RS04565	COG2409	Drug exporters of the RND superfamily
I8755_RS04570	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I8755_RS04590	COG2226	methyltransferase
I8755_RS04620	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I8755_RS04630	COG2175	clavaminate synthase activity
I8755_RS04645	COG2409	Drug exporters of the RND superfamily
I8755_RS04670	COG4941	Belongs to the sigma-70 factor family
I8755_RS04675	COG0583	DNA-binding transcription factor activity
I8755_RS04690	COG0367	asparagine synthase
I8755_RS04710	COG2814	Major facilitator Superfamily
I8755_RS04735	COG1960	acyl-CoA dehydrogenase activity
I8755_RS04745	COG0242	peptide deformylase activity
I8755_RS04755	COG3442	glutamine amidotransferase
I8755_RS04760	COG0205	6-phosphofructokinase activity
I8755_RS04780	COG0204	Acyl-transferase
I8755_RS04790	COG0829	nickel cation binding
I8755_RS04795	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I8755_RS04805	COG0804	urea catabolic process
I8755_RS04810	COG0832	Belongs to the urease beta subunit family
I8755_RS04815	COG0831	urea catabolic process
I8755_RS04820	COG1309	transcriptional regulator
I8755_RS04835	COG0740	serine-type endopeptidase activity
I8755_RS04875	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I8755_RS04880	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I8755_RS04885	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I8755_RS04890	COG2226	methyltransferase
I8755_RS04930	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I8755_RS04950	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I8755_RS04970	COG4585	Histidine kinase
I8755_RS04975	COG2197	response regulator
I8755_RS04980	COG1940	carbohydrate kinase activity
I8755_RS04985	COG2188	Transcriptional regulator
I8755_RS04990	COG1595	DNA-templated transcription, initiation
I8755_RS05000	COG0346	lactoylglutathione lyase activity
I8755_RS05015	COG0626	cystathionine gamma-synthase activity
I8755_RS05030	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS05040	COG1522	sequence-specific DNA binding
I8755_RS05045	COG0419	ATPase involved in DNA repair
I8755_RS05050	COG0420	3'-5' exonuclease activity
I8755_RS05055	COG1739	Uncharacterized protein family UPF0029
I8755_RS05065	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I8755_RS05100	COG1832	CoA-binding protein
I8755_RS05110	COG0542	response to heat
I8755_RS05135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I8755_RS05135	COG0723	plastoquinol--plastocyanin reductase activity
I8755_RS05150	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I8755_RS05150	COG3608	succinylglutamate desuccinylase aspartoacylase
I8755_RS05155	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I8755_RS05160	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I8755_RS05165	COG2080	2 iron, 2 sulfur cluster binding
I8755_RS05185	COG1012	belongs to the aldehyde dehydrogenase family
I8755_RS05195	COG0432	Pfam Uncharacterised protein family UPF0047
I8755_RS05200	COG2072	flavoprotein involved in K transport
I8755_RS05205	COG2318	DinB family
I8755_RS05215	COG1132	(ABC) transporter
I8755_RS05225	COG0277	FAD linked oxidase domain protein
I8755_RS05250	COG1132	(ABC) transporter
I8755_RS05255	COG1132	(ABC) transporter
I8755_RS05260	COG1132	(ABC) transporter
I8755_RS05275	COG1946	Acyl-CoA thioesterase
I8755_RS05285	COG2018	Roadblock/LC7 domain
I8755_RS05335	COG3239	Fatty acid desaturase
I8755_RS05340	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I8755_RS05355	COG2115	Belongs to the xylose isomerase family
I8755_RS05360	COG1070	Carbohydrate kinase
I8755_RS05365	COG1940	carbohydrate kinase activity
I8755_RS05385	COG1012	belongs to the aldehyde dehydrogenase family
I8755_RS05425	COG2770	Histidine kinase
I8755_RS05425	COG2208	phosphoserine phosphatase activity
I8755_RS05460	COG1309	transcriptional regulator
I8755_RS05490	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS05500	COG2409	Drug exporters of the RND superfamily
I8755_RS05510	COG0745	RESPONSE REGULATOR receiver
I8755_RS05515	COG2205	protein histidine kinase activity
I8755_RS05520	COG3629	intracellular signal transduction
I8755_RS05520	COG3903	Transcriptional regulator
I8755_RS05560	COG0366	Alpha amylase catalytic
I8755_RS05565	COG1940	carbohydrate kinase activity
I8755_RS05565	COG1846	Transcriptional regulator
I8755_RS05580	COG3397	chitin binding
I8755_RS05620	COG2197	response regulator
I8755_RS05630	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I8755_RS05680	COG1120	ATPase activity
I8755_RS05685	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8755_RS05690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8755_RS05695	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I8755_RS05700	COG2375	cellular response to nickel ion
I8755_RS05705	COG3433	isochorismatase activity
I8755_RS05705	COG1535	isochorismatase
I8755_RS05715	COG1191	sigma factor activity
I8755_RS05730	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I8755_RS05735	COG3281	Trehalose synthase
I8755_RS05745	COG0366	Alpha amylase catalytic
I8755_RS05775	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS05785	COG0659	secondary active sulfate transmembrane transporter activity
I8755_RS05805	COG2814	Major facilitator Superfamily
I8755_RS05835	COG0019	diaminopimelate decarboxylase activity
I8755_RS05850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I8755_RS05895	COG0444	Belongs to the ABC transporter superfamily
I8755_RS05900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I8755_RS05905	COG0601	transmembrane transport
I8755_RS05915	COG1960	acyl-CoA dehydrogenase activity
I8755_RS05920	COG1960	acyl-CoA dehydrogenase activity
I8755_RS05955	COG0247	lactate metabolic process
I8755_RS05960	COG1139	Iron-sulfur cluster binding protein
I8755_RS05965	COG1556	Lactate utilization protein
I8755_RS05985	COG1174	glycine betaine transport
I8755_RS06015	COG2376	Dihydroxyacetone kinase
I8755_RS06020	COG1461	Dihydroxyacetone kinase
I8755_RS06055	COG1902	pentaerythritol trinitrate reductase activity
I8755_RS06055	COG0446	pyridine nucleotide-disulphide oxidoreductase
I8755_RS06060	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I8755_RS06065	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I8755_RS06070	COG2813	Specifically methylates the guanine in position
I8755_RS06090	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I8755_RS06095	COG1215	transferase activity, transferring glycosyl groups
I8755_RS06130	COG1349	DNA-binding transcription factor activity
I8755_RS06185	COG1940	carbohydrate kinase activity
I8755_RS06195	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I8755_RS06200	COG1595	DNA-templated transcription, initiation
I8755_RS06220	COG0445	tRNA wobble uridine modification
I8755_RS06230	COG1660	Displays ATPase and GTPase activities
I8755_RS06250	COG3345	alpha-galactosidase
I8755_RS06265	COG0515	serine threonine protein kinase
I8755_RS06280	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I8755_RS06300	COG0204	Acyl-transferase
I8755_RS06330	COG1191	sigma factor activity
I8755_RS06345	COG1366	Belongs to the anti-sigma-factor antagonist family
I8755_RS06350	COG1366	Belongs to the anti-sigma-factor antagonist family
I8755_RS06355	COG2172	sigma factor antagonist activity
I8755_RS06375	COG4044	May play a role in the intracellular transport of hydrophobic ligands
I8755_RS06390	COG1191	sigma factor activity
I8755_RS06415	COG0456	acetyltransferase
I8755_RS06415	COG1846	Transcriptional regulator
I8755_RS06420	COG2376	Dihydroxyacetone kinase
I8755_RS06430	COG1597	lipid kinase activity
I8755_RS06435	COG0596	Alpha beta hydrolase
I8755_RS06445	COG0671	phosphoesterase, PA-phosphatase related
I8755_RS06450	COG0584	glycerophosphoryl diester phosphodiesterase
I8755_RS06465	COG1252	NADH dehydrogenase
I8755_RS06485	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
I8755_RS06495	COG0671	phosphoesterase, PA-phosphatase related
I8755_RS06505	COG1309	transcriptional regulator
I8755_RS06530	COG1902	pentaerythritol trinitrate reductase activity
I8755_RS06550	COG1940	carbohydrate kinase activity
I8755_RS06565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I8755_RS06575	COG2040	homocysteine
I8755_RS06585	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I8755_RS06600	COG2706	6-phosphogluconolactonase activity
I8755_RS06615	COG1335	isochorismatase
I8755_RS06620	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS06625	COG0531	amino acid
I8755_RS06650	COG3485	protocatechuate 3,4-dioxygenase
I8755_RS06690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I8755_RS06695	COG0252	asparaginase activity
I8755_RS06720	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I8755_RS06775	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I8755_RS06790	COG1968	undecaprenyl-diphosphatase activity
I8755_RS06795	COG4195	phage-related replication protein
I8755_RS06815	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I8755_RS06820	COG0673	inositol 2-dehydrogenase activity
I8755_RS06845	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I8755_RS06900	COG0697	spore germination
I8755_RS06915	COG0697	spore germination
I8755_RS06935	COG2890	protein-(glutamine-N5) methyltransferase activity
I8755_RS06940	COG1695	Transcriptional regulator
I8755_RS06990	COG0384	phenazine biosynthesis protein PhzF
I8755_RS07020	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I8755_RS07020	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I8755_RS07030	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I8755_RS07050	COG1716	ATPase activity
I8755_RS07070	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I8755_RS07100	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I8755_RS07110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I8755_RS07125	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
I8755_RS07135	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I8755_RS07140	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I8755_RS07145	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I8755_RS07175	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I8755_RS07185	COG1414	Transcriptional regulator
I8755_RS07200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I8755_RS07230	COG2814	Major facilitator Superfamily
I8755_RS07235	COG4336	lyase activity
I8755_RS07240	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I8755_RS07245	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I8755_RS07250	COG1984	allophanate hydrolase subunit 2
I8755_RS07275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8755_RS07290	COG2270	Major facilitator Superfamily
I8755_RS07305	COG0463	Glycosyl transferase, family 2
I8755_RS07330	COG1960	acyl-CoA dehydrogenase activity
I8755_RS07380	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I8755_RS07385	COG0140	phosphoribosyl-ATP diphosphatase activity
I8755_RS07390	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I8755_RS07395	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I8755_RS07395	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I8755_RS07400	COG3201	nicotinamide mononucleotide transporter
I8755_RS07420	COG1940	carbohydrate kinase activity
I8755_RS07420	COG1846	Transcriptional regulator
I8755_RS07425	COG0738	Major facilitator superfamily
I8755_RS07430	COG2233	PERMEase
I8755_RS07450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I8755_RS07465	COG0531	amino acid
I8755_RS07480	COG2390	Transcriptional regulator
I8755_RS07485	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I8755_RS07495	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I8755_RS07510	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I8755_RS07525	COG0194	GDP metabolic process
I8755_RS07535	COG0284	orotidine-5'-phosphate decarboxylase activity
I8755_RS07540	COG0167	dihydroorotate dehydrogenase activity
I8755_RS07545	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I8755_RS07550	COG0505	Belongs to the CarA family
I8755_RS07560	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I8755_RS07565	COG0540	Belongs to the ATCase OTCase family
I8755_RS07570	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I8755_RS07580	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I8755_RS07585	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I8755_RS07590	COG0006	proline dipeptidase activity
I8755_RS07600	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I8755_RS07605	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I8755_RS07610	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I8755_RS07615	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I8755_RS07620	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I8755_RS07625	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I8755_RS07630	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I8755_RS07650	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I8755_RS07665	COG0124	histidyl-tRNA synthetase
I8755_RS07680	COG1196	nuclear chromosome segregation
I8755_RS07685	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I8755_RS07690	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I8755_RS07695	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I8755_RS07700	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I8755_RS07710	COG2255	four-way junction helicase activity
I8755_RS07715	COG0632	four-way junction helicase activity
I8755_RS07720	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I8755_RS07725	COG0217	transcriptional regulatory protein
I8755_RS07730	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I8755_RS07735	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I8755_RS07745	COG0438	transferase activity, transferring glycosyl groups
I8755_RS07750	COG1560	Kdo2-lipid A biosynthetic process
I8755_RS07755	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I8755_RS07775	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I8755_RS07790	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I8755_RS07850	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I8755_RS07850	COG0512	Glutamine amidotransferase of anthranilate synthase
I8755_RS07905	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I8755_RS07905	COG1648	precorrin-2 dehydrogenase activity
I8755_RS07910	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I8755_RS07925	COG1464	Belongs to the NlpA lipoprotein family
I8755_RS07935	COG2011	ABC-type metal ion transport system permease component
I8755_RS07940	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I8755_RS07965	COG0584	glycerophosphoryl diester phosphodiesterase
I8755_RS07970	COG0318	PFAM AMP-dependent synthetase and ligase
I8755_RS07970	COG0204	Acyl-transferase
I8755_RS07975	COG0477	Major facilitator Superfamily
I8755_RS07990	COG0165	Argininosuccinate lyase
I8755_RS08000	COG0385	Bile acid
I8755_RS08005	COG1438	arginine binding
I8755_RS08010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I8755_RS08015	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I8755_RS08020	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I8755_RS08025	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I8755_RS08035	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I8755_RS08055	COG2838	Isocitrate dehydrogenase
I8755_RS08070	COG0667	Aldo Keto reductase
I8755_RS08085	COG0697	spore germination
I8755_RS08095	COG1649	PFAM Uncharacterised BCR, COG1649
I8755_RS08125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I8755_RS08125	COG0072	phenylalanine-tRNA ligase activity
I8755_RS08130	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I8755_RS08135	COG5002	protein histidine kinase activity
I8755_RS08140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I8755_RS08145	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I8755_RS08150	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I8755_RS08155	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I8755_RS08190	COG3830	Belongs to the UPF0237 family
I8755_RS08190	COG0560	Phosphoserine phosphatase
I8755_RS08200	COG1012	belongs to the aldehyde dehydrogenase family
I8755_RS08205	COG0174	glutamine synthetase
I8755_RS08215	COG0531	amino acid
I8755_RS08220	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I8755_RS08260	COG4175	Glycine betaine
I8755_RS08260	COG0517	IMP dehydrogenase activity
I8755_RS08265	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I8755_RS08320	COG0805	protein transport
I8755_RS08325	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I8755_RS08345	COG2378	regulation of single-species biofilm formation
I8755_RS08360	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I8755_RS08370	COG1609	Transcriptional regulator
I8755_RS08375	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I8755_RS08380	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I8755_RS08395	COG4122	O-methyltransferase activity
I8755_RS08400	COG1222	aaa ATPase
I8755_RS08420	COG1994	Peptidase M50
I8755_RS08420	COG0517	IMP dehydrogenase activity
I8755_RS08430	COG2197	response regulator
I8755_RS08435	COG0747	negative chemotaxis
I8755_RS08445	COG0646	methionine synthase
I8755_RS08445	COG1410	methionine synthase
I8755_RS08450	COG1414	Transcriptional regulator
I8755_RS08455	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I8755_RS08460	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I8755_RS08465	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I8755_RS08475	COG0402	S-adenosylhomocysteine deaminase activity
I8755_RS08480	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I8755_RS08490	COG2186	Transcriptional regulator
I8755_RS08500	COG0215	cysteine-tRNA ligase activity
I8755_RS08515	COG0406	alpha-ribazole phosphatase activity
I8755_RS08520	COG0598	Magnesium transport protein CorA
I8755_RS08530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8755_RS08535	COG0667	Aldo Keto reductase
I8755_RS08565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I8755_RS08575	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I8755_RS08580	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I8755_RS08585	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I8755_RS08600	COG0662	Cupin 2, conserved barrel domain protein
I8755_RS08615	COG3012	SEC-C Motif Domain Protein
I8755_RS08625	COG3265	gluconokinase activity
I8755_RS08645	COG3573	Dehydrogenase
I8755_RS08655	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I8755_RS08660	COG2149	membrane
I8755_RS08690	COG0318	PFAM AMP-dependent synthetase and ligase
I8755_RS08710	COG0477	Major facilitator Superfamily
I8755_RS08740	COG0789	Transcriptional regulator
I8755_RS08760	COG1960	acyl-CoA dehydrogenase activity
I8755_RS08770	COG0640	Transcriptional regulator
I8755_RS08805	COG2851	Citrate transporter
I8755_RS08810	COG1309	transcriptional regulator
I8755_RS08815	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I8755_RS08820	COG2188	Transcriptional regulator
I8755_RS08855	COG2755	lipolytic protein G-D-S-L family
I8755_RS08870	COG0463	Glycosyl transferase, family 2
I8755_RS08880	COG0726	polysaccharide deacetylase
I8755_RS08880	COG1649	PFAM Uncharacterised BCR, COG1649
I8755_RS08895	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I8755_RS08900	COG1725	Transcriptional regulator
I8755_RS08905	COG0456	acetyltransferase
I8755_RS08905	COG0454	-acetyltransferase
I8755_RS08940	COG4565	transcriptional regulatory protein
I8755_RS08955	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I8755_RS08960	COG0587	DNA-directed DNA polymerase activity
I8755_RS08985	COG1799	cell septum assembly
I8755_RS08990	COG1960	acyl-CoA dehydrogenase activity
I8755_RS08995	COG0477	Major facilitator Superfamily
I8755_RS09005	COG0671	phosphoesterase, PA-phosphatase related
I8755_RS09015	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I8755_RS09030	COG0438	transferase activity, transferring glycosyl groups
I8755_RS09055	COG1160	GTP binding
I8755_RS09065	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I8755_RS09090	COG1187	pseudouridine synthase activity
I8755_RS09095	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I8755_RS09100	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I8755_RS09115	COG0686	Belongs to the AlaDH PNT family
I8755_RS09125	COG0494	nUDIX hydrolase
I8755_RS09130	COG0504	CTP synthase activity
I8755_RS09135	COG3387	PFAM Glycoside hydrolase 15-related
I8755_RS09140	COG1902	pentaerythritol trinitrate reductase activity
I8755_RS09150	COG1309	transcriptional regulator
I8755_RS09160	COG0438	transferase activity, transferring glycosyl groups
I8755_RS09165	COG0497	DNA recombination
I8755_RS09175	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I8755_RS09195	COG1120	ATPase activity
I8755_RS09200	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8755_RS09205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8755_RS09215	COG0647	UMP catabolic process
I8755_RS09250	COG2094	Belongs to the DNA glycosylase MPG family
I8755_RS09260	COG1881	PFAM PEBP family protein
I8755_RS09280	COG1119	ATPase activity
I8755_RS09300	COG2197	response regulator
I8755_RS09305	COG4585	Histidine kinase
I8755_RS09315	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I8755_RS09325	COG1716	ATPase activity
I8755_RS09325	COG1131	(ABC) transporter
I8755_RS09325	COG0842	Transport permease protein
I8755_RS09335	COG3830	Belongs to the UPF0237 family
I8755_RS09335	COG0560	Phosphoserine phosphatase
I8755_RS09355	COG2186	Transcriptional regulator
I8755_RS09365	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I8755_RS09370	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS09385	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I8755_RS09405	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I8755_RS09410	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I8755_RS09455	COG0326	Molecular chaperone. Has ATPase activity
I8755_RS09480	COG3387	PFAM Glycoside hydrolase 15-related
I8755_RS09530	COG0488	(ABC) transporter
I8755_RS09550	COG0235	Class ii aldolase
I8755_RS09565	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I8755_RS09570	COG1492	cobalamin metabolic process
I8755_RS09585	COG1797	cobyrinic acid a,c-diamide synthase activity
I8755_RS09610	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I8755_RS09615	COG2318	DinB family
I8755_RS09620	COG0456	acetyltransferase
I8755_RS09625	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I8755_RS09630	COG1917	Cupin 2, conserved barrel domain protein
I8755_RS09635	COG5285	phytanoyl-CoA dioxygenase
I8755_RS09640	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I8755_RS09660	COG1414	Transcriptional regulator
I8755_RS09675	COG4585	Histidine kinase
I8755_RS09680	COG2197	response regulator
I8755_RS09685	COG0768	penicillin binding
I8755_RS09695	COG1695	Transcriptional regulator
I8755_RS09725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I8755_RS09730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I8755_RS09735	COG1349	DNA-binding transcription factor activity
I8755_RS09750	COG0395	ABC-type sugar transport system, permease component
I8755_RS09755	COG1063	alcohol dehydrogenase
I8755_RS09830	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I8755_RS09840	COG1595	DNA-templated transcription, initiation
I8755_RS09845	COG2171	N-acyltransferase activity
I8755_RS09850	COG3226	Transcriptional regulator
I8755_RS09865	COG0822	iron-sulfur transferase activity
I8755_RS09870	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I8755_RS09875	COG0396	ATPase activity
I8755_RS09885	COG0719	Fe-S assembly protein
I8755_RS09925	COG0109	protoheme IX farnesyltransferase activity
I8755_RS09935	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I8755_RS09950	COG0363	glucosamine-6-phosphate deaminase activity
I8755_RS09960	COG0166	Belongs to the GPI family
I8755_RS09970	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I8755_RS09975	COG0149	triose-phosphate isomerase activity
I8755_RS09980	COG0126	phosphoglycerate kinase activity
I8755_RS09985	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I8755_RS09995	COG1481	regulation of sporulation
I8755_RS10000	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I8755_RS10005	COG1660	Displays ATPase and GTPase activities
I8755_RS10045	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I8755_RS10060	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I8755_RS10065	COG1619	proteins homologs of microcin C7 resistance protein MccF
I8755_RS10070	COG0387	Pfam Sodium calcium exchanger
I8755_RS10090	COG0556	nucleotide-excision repair
I8755_RS10100	COG0584	glycerophosphoryl diester phosphodiesterase
I8755_RS10105	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I8755_RS10120	COG0598	Magnesium transport protein CorA
I8755_RS10180	COG0402	S-adenosylhomocysteine deaminase activity
I8755_RS10210	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I8755_RS10230	COG2267	carboxylic ester hydrolase activity
I8755_RS10245	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I8755_RS10260	COG0237	dephospho-CoA kinase activity
I8755_RS10285	COG1643	Atp-dependent helicase
I8755_RS10320	COG2050	protein possibly involved in aromatic compounds catabolism
I8755_RS10385	COG0737	Belongs to the 5'-nucleotidase family
I8755_RS10405	COG0702	epimerase
I8755_RS10415	COG0287	Prephenate dehydrogenase
I8755_RS10415	COG1605	Chorismate mutase
I8755_RS10430	COG0366	Alpha amylase catalytic
I8755_RS10430	COG1470	cell adhesion involved in biofilm formation
I8755_RS10445	COG1357	PFAM Pentapeptide repeats (8 copies)
I8755_RS10455	COG1278	Cold shock
I8755_RS10465	COG2304	oxidoreductase activity
I8755_RS10470	COG0395	ABC-type sugar transport system, permease component
I8755_RS10475	COG1175	transmembrane transport
I8755_RS10490	COG0070	glutamate synthase
I8755_RS10490	COG0069	glutamate synthase activity
I8755_RS10490	COG0067	glutamate synthase
I8755_RS10520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I8755_RS10525	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I8755_RS10535	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I8755_RS10545	COG0159	tryptophan synthase activity
I8755_RS10550	COG0133	tryptophan synthase activity
I8755_RS10555	COG0134	indole-3-glycerol-phosphate synthase activity
I8755_RS10575	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I8755_RS10580	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I8755_RS10590	COG0107	imidazoleglycerol-phosphate synthase activity
I8755_RS10595	COG0251	oxidation-reduction process
I8755_RS10600	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I8755_RS10605	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I8755_RS10615	COG0131	Imidazoleglycerol-phosphate dehydratase
I8755_RS10620	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I8755_RS10625	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I8755_RS10640	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I8755_RS10645	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I8755_RS10665	COG1432	Conserved Protein
I8755_RS10675	COG0587	DNA-directed DNA polymerase activity
I8755_RS10725	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I8755_RS10735	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I8755_RS10740	COG3599	regulation of cell shape
I8755_RS10750	COG1799	cell septum assembly
I8755_RS10760	COG1496	oxidoreductase activity
I8755_RS10765	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I8755_RS10770	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I8755_RS10775	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I8755_RS10785	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I8755_RS10790	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I8755_RS10800	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I8755_RS10805	COG0768	penicillin binding
I8755_RS10815	COG0275	rRNA processing
I8755_RS10825	COG0714	Associated with various cellular activities
I8755_RS10845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I8755_RS10855	COG1309	transcriptional regulator
I8755_RS10880	COG0352	thiamine-phosphate diphosphorylase activity
I8755_RS10895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I8755_RS10895	COG2022	thiamine diphosphate biosynthetic process
I8755_RS10905	COG2022	thiamine diphosphate biosynthetic process
I8755_RS10910	COG2815	serine threonine protein kinase
I8755_RS10910	COG0515	serine threonine protein kinase
I8755_RS10915	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I8755_RS10920	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I8755_RS10925	COG2193	ferroxidase activity
I8755_RS10930	COG0243	molybdopterin cofactor binding
I8755_RS10935	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I8755_RS10960	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I8755_RS10965	COG0205	6-phosphofructokinase activity
I8755_RS10970	COG2197	response regulator
I8755_RS10975	COG4585	Histidine kinase
I8755_RS11000	COG1940	carbohydrate kinase activity
I8755_RS11010	COG0003	Pfam Anion-transporting ATPase
I8755_RS11050	COG0791	NLP P60 protein
I8755_RS11080	COG2205	protein histidine kinase activity
I8755_RS11085	COG0745	RESPONSE REGULATOR receiver
I8755_RS11095	COG1929	Belongs to the glycerate kinase type-1 family
I8755_RS11100	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I8755_RS11105	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I8755_RS11110	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I8755_RS11115	COG0723	plastoquinol--plastocyanin reductase activity
I8755_RS11120	COG2010	Cytochrome c
I8755_RS11125	COG1845	cytochrome c oxidase, subunit III
I8755_RS11135	COG1376	ErfK ybiS ycfS ynhG family protein
I8755_RS11145	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I8755_RS11150	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I8755_RS11160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I8755_RS11180	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I8755_RS11185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I8755_RS11190	COG2197	response regulator
I8755_RS11195	COG4585	Histidine kinase
I8755_RS11215	COG4106	trans-aconitate 2-methyltransferase activity
I8755_RS11235	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I8755_RS11240	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I8755_RS11240	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I8755_RS11255	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I8755_RS11260	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I8755_RS11265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I8755_RS11270	COG0508	dehydrogenase complex catalyzes the overall conversion of
I8755_RS11280	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I8755_RS11325	COG0321	lipoyl(octanoyl) transferase activity
I8755_RS11330	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I8755_RS11365	COG1120	ATPase activity
I8755_RS11370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8755_RS11390	COG2267	carboxylic ester hydrolase activity
I8755_RS11410	COG0745	RESPONSE REGULATOR receiver
I8755_RS11425	COG4585	Histidine kinase
I8755_RS11430	COG2197	response regulator
I8755_RS11480	COG0366	Alpha amylase catalytic
I8755_RS11485	COG1609	Transcriptional regulator
I8755_RS11495	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I8755_RS11520	COG0174	glutamine synthetase
I8755_RS11530	COG1959	2 iron, 2 sulfur cluster binding
I8755_RS11545	COG2267	carboxylic ester hydrolase activity
I8755_RS11555	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I8755_RS11555	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I8755_RS11560	COG2814	Major facilitator Superfamily
I8755_RS11575	COG0477	Major facilitator Superfamily
I8755_RS11580	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I8755_RS11605	COG1994	Peptidase M50
I8755_RS11675	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I8755_RS11680	COG2814	Major facilitator Superfamily
I8755_RS11685	COG3540	Alkaline phosphatase
I8755_RS11710	COG2259	Doxx family
I8755_RS11720	COG2226	methyltransferase
I8755_RS11835	COG1674	ftsk spoiiie
I8755_RS11855	COG1476	TRANSCRIPTIONal
I8755_RS11895	COG3022	response to hydroperoxide
I8755_RS11900	COG0800	Aldolase
I8755_RS11915	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I8755_RS11930	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS11940	COG2030	dehydratase
I8755_RS11945	COG4585	Histidine kinase
I8755_RS11955	COG2197	response regulator
I8755_RS11965	COG0183	Belongs to the thiolase family
I8755_RS11980	COG0860	N-Acetylmuramoyl-L-alanine amidase
I8755_RS11990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8755_RS12015	COG0438	transferase activity, transferring glycosyl groups
I8755_RS12020	COG1309	transcriptional regulator
I8755_RS12055	COG3845	ABC transporter
I8755_RS12070	COG0183	Belongs to the thiolase family
I8755_RS12075	COG2124	cytochrome p450
I8755_RS12120	COG0456	acetyltransferase
I8755_RS12135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I8755_RS12195	COG0800	Aldolase
I8755_RS12200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I8755_RS12215	COG1358	cellular component organization or biogenesis
I8755_RS12260	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I8755_RS12270	COG0477	Major facilitator Superfamily
I8755_RS12275	COG1309	transcriptional regulator
I8755_RS12290	COG4585	Histidine kinase
I8755_RS12295	COG2197	response regulator
I8755_RS12310	COG0667	Aldo Keto reductase
I8755_RS12315	COG0789	Transcriptional regulator
I8755_RS12325	COG1741	Belongs to the pirin family
I8755_RS12340	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I8755_RS12345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8755_RS12350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I8755_RS12380	COG0583	DNA-binding transcription factor activity
I8755_RS12385	COG3226	Transcriptional regulator
I8755_RS12415	COG1764	response to oxidative stress
I8755_RS12420	COG2130	NADP-dependent
I8755_RS12465	COG4981	capsule polysaccharide biosynthetic process
I8755_RS12505	COG2855	membrane
I8755_RS12515	COG0583	DNA-binding transcription factor activity
I8755_RS12520	COG0318	PFAM AMP-dependent synthetase and ligase
I8755_RS12530	COG1077	Cell shape determining protein MreB Mrl
I8755_RS12555	COG3585	molybdate ion transport
I8755_RS12560	COG1295	ribonuclease BN
I8755_RS12585	COG1070	Carbohydrate kinase
I8755_RS12600	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I8755_RS12605	COG0358	DNA primase activity
I8755_RS12615	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I8755_RS12625	COG2949	membrane
I8755_RS12630	COG0243	molybdopterin cofactor binding
I8755_RS12670	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I8755_RS12675	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I8755_RS12675	COG2146	nitrite reductase [NAD(P)H] activity
I8755_RS12685	COG1309	transcriptional regulator
I8755_RS12690	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS12700	COG1175	transmembrane transport
I8755_RS12715	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I8755_RS12715	COG0574	Belongs to the PEP-utilizing enzyme family
I8755_RS12745	COG0423	glycine-tRNA ligase activity
I8755_RS12750	COG0803	Belongs to the bacterial solute-binding protein 9 family
I8755_RS12750	COG3443	Belongs to the bacterial solute-binding protein 9 family
I8755_RS12755	COG1121	(ABC) transporter
I8755_RS12760	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I8755_RS12770	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I8755_RS12775	COG1381	Involved in DNA repair and RecF pathway recombination
I8755_RS12830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8755_RS12835	COG0747	negative chemotaxis
I8755_RS12845	COG0444	Belongs to the ABC transporter superfamily
I8755_RS12850	COG4608	Belongs to the ABC transporter superfamily
I8755_RS12855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I8755_RS12860	COG2197	response regulator
I8755_RS12865	COG4585	Histidine kinase
I8755_RS12870	COG2409	Drug exporters of the RND superfamily
I8755_RS12880	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I8755_RS12895	COG2723	6-phospho-beta-galactosidase activity
I8755_RS12905	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I8755_RS12935	COG2315	Protein conserved in bacteria
I8755_RS12945	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I8755_RS12955	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I8755_RS12955	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I8755_RS12960	COG4948	Mandelate Racemase Muconate Lactonizing
I8755_RS12970	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I8755_RS12975	COG1234	tRNA 3'-trailer cleavage
I8755_RS12980	COG0537	adenosine 5'-monophosphoramidase activity
I8755_RS12985	COG4946	Tricorn protease homolog
I8755_RS12985	COG0793	Belongs to the peptidase S41A family
I8755_RS13005	COG2070	2-Nitropropane dioxygenase
I8755_RS13010	COG0484	heat shock protein binding
I8755_RS13015	COG1420	regulation of RNA biosynthetic process
I8755_RS13055	COG0481	GTPase activity
I8755_RS13060	COG0268	Binds directly to 16S ribosomal RNA
I8755_RS13065	COG3547	Transposase (IS116 IS110 IS902 family)
I8755_RS13080	COG2353	YceI-like domain
I8755_RS13085	COG1234	tRNA 3'-trailer cleavage
I8755_RS13090	COG1555	photosystem II stabilization
I8755_RS13095	COG1307	EDD domain protein, DegV family
I8755_RS13105	COG0495	leucyl-tRNA aminoacylation
I8755_RS13115	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I8755_RS13140	COG0477	Major facilitator Superfamily
I8755_RS13155	COG0588	phosphoglycerate mutase activity
I8755_RS13160	COG0799	negative regulation of ribosome biogenesis
I8755_RS13170	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I8755_RS13185	COG0501	Belongs to the peptidase M48B family
I8755_RS13200	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I8755_RS13210	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I8755_RS13220	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I8755_RS13225	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I8755_RS13230	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I8755_RS13240	COG1530	ribonuclease E activity
I8755_RS13270	COG0772	Belongs to the SEDS family
I8755_RS13275	COG0768	penicillin binding
I8755_RS13290	COG1077	Cell shape determining protein MreB Mrl
I8755_RS13295	COG0105	UTP biosynthetic process
I8755_RS13305	COG0285	dihydrofolate synthase activity
I8755_RS13310	COG1077	Cell shape determining protein MreB Mrl
I8755_RS13320	COG0525	valine-tRNA ligase activity
I8755_RS13345	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I8755_RS13350	COG0740	serine-type endopeptidase activity
I8755_RS13355	COG0740	serine-type endopeptidase activity
I8755_RS13360	COG0544	peptidyl-prolyl cis-trans isomerase activity
I8755_RS13380	COG3594	Acyltransferase
I8755_RS13395	COG1136	(ABC) transporter
I8755_RS13400	COG0475	glutathione-regulated potassium exporter activity
I8755_RS13410	COG4552	Acetyltransferase involved in intracellular survival and related
I8755_RS13425	COG1113	amino acid transport
I8755_RS13430	COG1268	BioY protein
I8755_RS13435	COG1113	amino acid transport
I8755_RS13440	COG1113	amino acid transport
I8755_RS13445	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I8755_RS13455	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I8755_RS13510	COG0583	DNA-binding transcription factor activity
I8755_RS13540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I8755_RS13575	COG0668	transmembrane transport
I8755_RS13580	COG1940	carbohydrate kinase activity
I8755_RS13580	COG1846	Transcriptional regulator
I8755_RS13590	COG1175	transmembrane transport
I8755_RS13595	COG0395	ABC-type sugar transport system, permease component
I8755_RS13600	COG1486	melibiose metabolic process
I8755_RS13615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I8755_RS13645	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I8755_RS13650	COG2346	COG2346, Truncated hemoglobins
I8755_RS13675	COG0629	single-stranded DNA binding
I8755_RS13715	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I8755_RS13735	COG1131	(ABC) transporter
I8755_RS13755	COG3962	Belongs to the TPP enzyme family
I8755_RS13760	COG3718	enzyme involved in inositol metabolism
I8755_RS13770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I8755_RS13800	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I8755_RS13815	COG0673	inositol 2-dehydrogenase activity
I8755_RS13820	COG1609	Transcriptional regulator
I8755_RS13830	COG1280	lysine exporter protein (LysE YggA)
I8755_RS13835	COG0456	acetyltransferase
I8755_RS13835	COG1846	Transcriptional regulator
I8755_RS13855	COG1472	Belongs to the glycosyl hydrolase 3 family
I8755_RS13910	COG0028	Belongs to the TPP enzyme family
I8755_RS13920	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I8755_RS13940	COG1946	Acyl-CoA thioesterase
I8755_RS13945	COG1960	acyl-CoA dehydrogenase activity
I8755_RS13950	COG1309	transcriptional regulator
I8755_RS13955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I8755_RS13965	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I8755_RS13970	COG1960	acyl-CoA dehydrogenase activity
I8755_RS13995	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I8755_RS14000	COG0589	response to stress
I8755_RS14010	COG4977	sequence-specific DNA binding
I8755_RS14015	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I8755_RS14040	COG0395	ABC-type sugar transport system, permease component
I8755_RS14050	COG3979	chitinase
I8755_RS14060	COG0745	RESPONSE REGULATOR receiver
I8755_RS14085	COG0406	alpha-ribazole phosphatase activity
I8755_RS14135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8755_RS14165	COG0154	amidase activity
I8755_RS14185	COG0765	amino acid transport
I8755_RS14190	COG1126	abc transporter atp-binding protein
I8755_RS14205	COG0586	Pfam SNARE associated Golgi protein
I8755_RS14210	COG4585	Histidine kinase
I8755_RS14220	COG4585	Histidine kinase
I8755_RS14230	COG2409	Drug exporters of the RND superfamily
I8755_RS14250	COG3397	chitin binding
I8755_RS14265	COG2186	Transcriptional regulator
I8755_RS14325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I8755_RS14330	COG2188	Transcriptional regulator
I8755_RS14345	COG0673	inositol 2-dehydrogenase activity
I8755_RS14350	COG4702	Belongs to the UPF0303 family
I8755_RS14360	COG0706	membrane insertase activity
I8755_RS14370	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I8755_RS14385	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I8755_RS14455	COG0590	tRNA wobble adenosine to inosine editing
I8755_RS14460	COG0590	tRNA wobble adenosine to inosine editing
I8755_RS14475	COG2271	Major facilitator Superfamily
I8755_RS14480	COG2814	Major facilitator Superfamily
I8755_RS14480	COG0477	Major facilitator Superfamily
I8755_RS14485	COG2733	membrane
I8755_RS14540	COG0477	Major facilitator Superfamily
I8755_RS14560	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I8755_RS14570	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I8755_RS14575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8755_RS14580	COG1263	PTS System
I8755_RS14585	COG1263	PTS System
I8755_RS14590	COG1234	tRNA 3'-trailer cleavage
I8755_RS14615	COG1113	amino acid transport
I8755_RS14625	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I8755_RS14635	COG1335	isochorismatase
I8755_RS14670	COG0277	FAD linked oxidase domain protein
I8755_RS14690	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I8755_RS14705	COG3480	Lon protease (S16) C-terminal proteolytic domain
I8755_RS14740	COG2318	DinB family
I8755_RS14775	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I8755_RS14785	COG1678	Uncharacterized ACR, COG1678
I8755_RS14790	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I8755_RS14795	COG0776	regulation of translation
I8755_RS14805	COG3973	AAA domain
I8755_RS14830	COG2223	nitrite transmembrane transporter activity
I8755_RS14835	COG1846	Transcriptional regulator
I8755_RS14840	COG0697	spore germination
I8755_RS14870	COG0583	DNA-binding transcription factor activity
I8755_RS14880	COG2027	D-alanyl-D-alanine carboxypeptidase
I8755_RS14890	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I8755_RS14895	COG0793	Belongs to the peptidase S41A family
I8755_RS14900	COG2177	Part of the ABC transporter FtsEX involved in
I8755_RS14905	COG2884	Cell division ATP-binding protein ftsE
I8755_RS14920	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I8755_RS14925	COG0515	serine threonine protein kinase
I8755_RS14930	COG0515	serine threonine protein kinase
I8755_RS14945	COG1175	transmembrane transport
I8755_RS14950	COG0395	ABC-type sugar transport system, permease component
I8755_RS14960	COG0438	transferase activity, transferring glycosyl groups
I8755_RS14965	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I8755_RS14995	COG1136	(ABC) transporter
I8755_RS14995	COG0577	efflux transmembrane transporter activity
I8755_RS15005	COG2197	response regulator
I8755_RS15020	COG1309	transcriptional regulator
I8755_RS15030	COG1134	teichoic acid transport
I8755_RS15035	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I8755_RS15040	COG1216	Glycosyl transferase, family 2
I8755_RS15050	COG0463	Glycosyl transferase, family 2
I8755_RS15055	COG2902	Dehydrogenase
I8755_RS15080	COG0653	protein targeting
I8755_RS15090	COG3214	Protein conserved in bacteria
I8755_RS15095	COG2197	response regulator
I8755_RS15100	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I8755_RS15110	COG0823	Involved in the tonB-independent uptake of proteins
I8755_RS15115	COG5000	phosphorelay sensor kinase activity
I8755_RS15115	COG5002	protein histidine kinase activity
I8755_RS15120	COG0745	RESPONSE REGULATOR receiver
I8755_RS15125	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I8755_RS15145	COG0714	Associated with various cellular activities
I8755_RS15185	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I8755_RS15195	COG1482	cell wall glycoprotein biosynthetic process
I8755_RS15205	COG2835	tetraacyldisaccharide 4'-kinase activity
I8755_RS15210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I8755_RS15215	COG1620	l-lactate permease
I8755_RS15250	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I8755_RS15255	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
I8755_RS15255	COG0778	Nitroreductase
I8755_RS15285	COG1316	TRANSCRIPTIONal
I8755_RS15300	COG1316	TRANSCRIPTIONal
I8755_RS15310	COG1316	TRANSCRIPTIONal
I8755_RS15330	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I8755_RS15390	COG2205	protein histidine kinase activity
I8755_RS15395	COG0745	RESPONSE REGULATOR receiver
I8755_RS15400	COG3104	oligopeptide transport
I8755_RS15425	COG1366	Belongs to the anti-sigma-factor antagonist family
I8755_RS15430	COG1191	sigma factor activity
I8755_RS15435	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I8755_RS15435	COG1672	PFAM Archaeal ATPase
I8755_RS15450	COG1228	amidohydrolase
I8755_RS15460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I8755_RS15465	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I8755_RS15470	COG0019	diaminopimelate decarboxylase activity
I8755_RS15505	COG2986	histidine ammonia-lyase
I8755_RS15515	COG1174	glycine betaine transport
I8755_RS15520	COG1174	glycine betaine transport
I8755_RS15530	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I8755_RS15540	COG2409	Drug exporters of the RND superfamily
I8755_RS15555	COG3629	intracellular signal transduction
I8755_RS15560	COG1012	belongs to the aldehyde dehydrogenase family
I8755_RS15575	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I8755_RS15580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8755_RS15585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I8755_RS15595	COG1960	acyl-CoA dehydrogenase activity
I8755_RS15600	COG3321	synthase
I8755_RS15605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8755_RS15610	COG0156	8-amino-7-oxononanoate synthase activity
I8755_RS15615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8755_RS15625	COG0500	methyltransferase
I8755_RS15640	COG0778	Nitroreductase
I8755_RS15650	COG2755	lipolytic protein G-D-S-L family
I8755_RS15655	COG0515	serine threonine protein kinase
I8755_RS15660	COG0183	Belongs to the thiolase family
I8755_RS15690	COG1136	(ABC) transporter
I8755_RS15695	COG0577	efflux transmembrane transporter activity
I8755_RS15700	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I8755_RS15705	COG1252	NADH dehydrogenase
I8755_RS15735	COG0148	phosphopyruvate hydratase activity
I8755_RS15750	COG2124	cytochrome p450
I8755_RS15815	COG0577	efflux transmembrane transporter activity
I8755_RS15820	COG1136	(ABC) transporter
I8755_RS15825	COG0477	Major facilitator Superfamily
I8755_RS15855	COG4585	Histidine kinase
I8755_RS15870	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I8755_RS15875	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I8755_RS15880	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I8755_RS15885	COG0193	aminoacyl-tRNA hydrolase activity
I8755_RS15890	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I8755_RS15910	COG4106	trans-aconitate 2-methyltransferase activity
I8755_RS15915	COG1846	Transcriptional regulator
I8755_RS15920	COG2197	response regulator
I8755_RS15960	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I8755_RS16000	COG0488	(ABC) transporter
I8755_RS16010	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I8755_RS16015	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I8755_RS16020	COG3584	3D domain protein
I8755_RS16020	COG3583	domain protein
I8755_RS16025	COG0084	hydrolase, TatD family'
I8755_RS16045	COG0768	penicillin binding
I8755_RS16050	COG0768	penicillin binding
I8755_RS16055	COG0442	prolyl-tRNA aminoacylation
I8755_RS16070	COG1695	Transcriptional regulator
I8755_RS16085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I8755_RS16095	COG2409	Drug exporters of the RND superfamily
I8755_RS16105	COG0793	Belongs to the peptidase S41A family
I8755_RS16105	COG4946	Tricorn protease homolog
I8755_RS16115	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS16125	COG2072	flavoprotein involved in K transport
I8755_RS16185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8755_RS16190	COG0521	Mo-molybdopterin cofactor biosynthetic process
I8755_RS16190	COG0315	cyclic pyranopterin monophosphate synthase activity
I8755_RS16195	COG0315	cyclic pyranopterin monophosphate synthase activity
I8755_RS16205	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I8755_RS16210	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I8755_RS16215	COG2366	antibiotic biosynthetic process
I8755_RS16235	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I8755_RS16245	COG1970	mechanosensitive ion channel activity
I8755_RS16260	COG3191	aminopeptidase activity
I8755_RS16280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I8755_RS16280	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I8755_RS16280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I8755_RS16290	COG1349	DNA-binding transcription factor activity
I8755_RS16295	COG0477	Major facilitator Superfamily
I8755_RS16310	COG1247	-acetyltransferase
I8755_RS16320	COG3384	dioxygenase
I8755_RS16325	COG1846	Transcriptional regulator
I8755_RS16345	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I8755_RS16355	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS16360	COG1169	isochorismate synthase
I8755_RS16365	COG1021	2,3-dihydroxybenzoate-AMP ligase
I8755_RS16370	COG1535	isochorismatase
I8755_RS16370	COG3433	isochorismatase activity
I8755_RS16375	COG1846	Transcriptional regulator
I8755_RS16380	COG1764	response to oxidative stress
I8755_RS16645	COG1061	Type III restriction enzyme res subunit
I8755_RS16725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8755_RS16745	COG5640	endopeptidase activity
I8755_RS16750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I8755_RS16780	COG1653	transport
I8755_RS16790	COG1686	Belongs to the peptidase S11 family
I8755_RS16815	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS16835	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I8755_RS16850	COG1012	belongs to the aldehyde dehydrogenase family
I8755_RS16865	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS16880	COG3629	intracellular signal transduction
I8755_RS16880	COG3903	Transcriptional regulator
I8755_RS16920	COG1024	Enoyl-CoA hydratase
I8755_RS16925	COG0515	serine threonine protein kinase
I8755_RS16925	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I8755_RS16935	COG1309	transcriptional regulator
I8755_RS16945	COG1960	acyl-CoA dehydrogenase activity
I8755_RS16955	COG0259	pyridoxamine-phosphate oxidase activity
I8755_RS16975	COG2072	flavoprotein involved in K transport
I8755_RS16985	COG1024	Enoyl-CoA hydratase
I8755_RS16990	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I8755_RS16995	COG2814	Major facilitator Superfamily
I8755_RS17010	COG1960	acyl-CoA dehydrogenase activity
I8755_RS17015	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS17030	COG1960	acyl-CoA dehydrogenase activity
I8755_RS17035	COG1960	acyl-CoA dehydrogenase activity
I8755_RS17040	COG0318	PFAM AMP-dependent synthetase and ligase
I8755_RS17055	COG1366	Belongs to the anti-sigma-factor antagonist family
I8755_RS17115	COG4821	SIS domain
I8755_RS17125	COG0596	Alpha beta hydrolase
I8755_RS17125	COG2945	thiolester hydrolase activity
I8755_RS17130	COG0259	pyridoxamine-phosphate oxidase activity
I8755_RS17145	COG1024	Enoyl-CoA hydratase
I8755_RS17160	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I8755_RS17185	COG2205	protein histidine kinase activity
I8755_RS17215	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I8755_RS17275	COG0667	Aldo Keto reductase
I8755_RS17305	COG2252	PERMEase
I8755_RS17315	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I8755_RS17335	COG2814	Major facilitator Superfamily
I8755_RS17345	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I8755_RS17350	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
I8755_RS17355	COG1278	Cold shock
I8755_RS17380	COG1061	Type III restriction enzyme res subunit
I8755_RS17390	COG3973	AAA domain
I8755_RS17445	COG1737	Transcriptional regulator
I8755_RS17450	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I8755_RS17505	COG0463	Glycosyl transferase, family 2
I8755_RS17530	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I8755_RS17545	COG1105	Belongs to the carbohydrate kinase PfkB family
I8755_RS17570	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I8755_RS17610	COG2197	response regulator
I8755_RS17650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I8755_RS17660	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I8755_RS17665	COG2188	Transcriptional regulator
I8755_RS17745	COG3842	ATPase activity
I8755_RS17755	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I8755_RS17765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I8755_RS17770	COG0215	cysteine-tRNA ligase activity
I8755_RS17775	COG3467	pyridoxamine 5'-phosphate
I8755_RS17780	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I8755_RS17785	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I8755_RS17790	COG1329	Transcriptional regulator
I8755_RS17805	COG5002	protein histidine kinase activity
I8755_RS17830	COG0588	phosphoglycerate mutase activity
I8755_RS17850	COG0438	transferase activity, transferring glycosyl groups
I8755_RS17940	COG1309	transcriptional regulator
I8755_RS17960	COG0768	penicillin binding
I8755_RS17995	COG2188	Transcriptional regulator
I8755_RS18005	COG2186	Transcriptional regulator
I8755_RS18015	COG4552	Acetyltransferase involved in intracellular survival and related
I8755_RS18025	COG1490	D-aminoacyl-tRNA deacylase activity
I8755_RS18035	COG0735	belongs to the Fur family
I8755_RS18040	COG3485	protocatechuate 3,4-dioxygenase
I8755_RS18060	COG2897	thiosulfate sulfurtransferase activity
I8755_RS18085	COG0745	RESPONSE REGULATOR receiver
I8755_RS18090	COG1609	Transcriptional regulator
I8755_RS18095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I8755_RS18100	COG0745	RESPONSE REGULATOR receiver
I8755_RS18110	COG0488	(ABC) transporter
I8755_RS18120	COG0737	Belongs to the 5'-nucleotidase family
I8755_RS18125	COG0456	acetyltransferase
I8755_RS18130	COG1725	Transcriptional regulator
I8755_RS18135	COG1116	anion transmembrane transporter activity
I8755_RS18145	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I8755_RS18175	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I8755_RS18180	COG0306	phosphate transporter
I8755_RS18190	COG1937	Protein conserved in bacteria
I8755_RS18210	COG0277	FAD linked oxidase domain protein
I8755_RS18215	COG0671	phosphoesterase, PA-phosphatase related
I8755_RS18220	COG0741	lytic transglycosylase activity
I8755_RS18220	COG0739	heme binding
I8755_RS18220	COG1196	nuclear chromosome segregation
I8755_RS18270	COG1131	(ABC) transporter
I8755_RS18280	COG4585	Histidine kinase
I8755_RS18285	COG2197	response regulator
I8755_RS18320	COG1252	NADH dehydrogenase
I8755_RS18350	COG0579	oxidoreductase
I8755_RS18355	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I8755_RS18410	COG0513	Belongs to the DEAD box helicase family
I8755_RS18450	COG0785	Cytochrome C biogenesis protein
I8755_RS18455	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I8755_RS18455	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I8755_RS18465	COG1643	Atp-dependent helicase
I8755_RS18500	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I8755_RS18530	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I8755_RS18535	COG0047	phosphoribosylformylglycinamidine synthase activity
I8755_RS18540	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I8755_RS18575	COG2197	response regulator
I8755_RS18585	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I8755_RS18600	COG0151	Belongs to the GarS family
I8755_RS18635	COG2197	response regulator
I8755_RS18670	COG0596	Alpha beta hydrolase
I8755_RS18695	COG0697	spore germination
I8755_RS18730	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I8755_RS18765	COG1191	sigma factor activity
I8755_RS18770	COG1191	sigma factor activity
I8755_RS18785	COG0477	Major facilitator Superfamily
I8755_RS18800	COG0477	Major facilitator Superfamily
I8755_RS18805	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I8755_RS18815	COG2205	protein histidine kinase activity
I8755_RS18820	COG0745	RESPONSE REGULATOR receiver
I8755_RS18845	COG0784	Response regulator, receiver
I8755_RS18850	COG0318	PFAM AMP-dependent synthetase and ligase
I8755_RS18855	COG1595	DNA-templated transcription, initiation
I8755_RS18900	COG0494	nUDIX hydrolase
I8755_RS19015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I8755_RS19030	COG0653	protein targeting
I8755_RS19050	COG0006	proline dipeptidase activity
I8755_RS19060	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I8755_RS19065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8755_RS19085	COG1999	signal sequence binding
I8755_RS19100	COG2837	iron assimilation
I8755_RS19110	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I8755_RS19115	COG0561	phosphatase activity
I8755_RS19150	COG0789	Transcriptional regulator
I8755_RS19155	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
I8755_RS19170	COG0561	phosphatase activity
I8755_RS19180	COG4988	ABC transporter
I8755_RS19185	COG1294	oxidase, subunit
I8755_RS19190	COG1271	oxidase subunit
I8755_RS19195	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I8755_RS19200	COG1609	Transcriptional regulator
I8755_RS19215	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I8755_RS19240	COG0662	Cupin 2, conserved barrel domain protein
I8755_RS19245	COG1950	PFAM Membrane protein of
I8755_RS19250	COG0626	cystathionine gamma-synthase activity
I8755_RS19285	COG2814	Major facilitator Superfamily
I8755_RS19305	COG0305	Participates in initiation and elongation during chromosome replication
I8755_RS19315	COG0359	binds to the 23S rRNA
I8755_RS19320	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I8755_RS19325	COG0629	single-stranded DNA binding
I8755_RS19330	COG0360	Binds together with S18 to 16S ribosomal RNA
I8755_RS19355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I8755_RS19365	COG1260	myo-inositol-1-phosphate synthase
I8755_RS19380	COG0617	tRNA 3'-terminal CCA addition
I8755_RS19400	COG1595	DNA-templated transcription, initiation
I8755_RS19410	COG0492	ferredoxin-NADP+ reductase activity
I8755_RS19415	COG3118	belongs to the thioredoxin family
I8755_RS19430	COG1192	Involved in chromosome partitioning
I8755_RS19435	COG0357	Ribosomal RNA small subunit methyltransferase G
I8755_RS19445	COG0706	membrane insertase activity
I8755_RS19450	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I8755_RS19455	COG0594	ribonuclease P activity
I8755_RS19460	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I8755_RS19465	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I8755_RS19470	COG0592	DNA-directed DNA polymerase activity
I8755_RS19475	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I8755_RS19480	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I8755_RS19485	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
I8755_RS19495	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I8755_RS19525	COG0515	serine threonine protein kinase
I8755_RS19550	COG0705	Rhomboid family
I8755_RS19565	COG3764	Sortase (surface protein transpeptidase)
I8755_RS19575	COG3764	Sortase (surface protein transpeptidase)
I8755_RS19580	COG3764	Sortase (surface protein transpeptidase)
I8755_RS19585	COG0515	serine threonine protein kinase
I8755_RS19605	COG1716	ATPase activity
I8755_RS19610	COG1716	ATPase activity
I8755_RS19630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I8755_RS19635	COG1960	acyl-CoA dehydrogenase activity
I8755_RS19640	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I8755_RS19645	COG2151	metal-sulfur cluster biosynthetic enzyme
I8755_RS19650	COG3396	Phenylacetate-CoA oxygenase
I8755_RS19655	COG3460	Phenylacetate-CoA oxygenase
I8755_RS19660	COG3396	Phenylacetate-CoA oxygenase
I8755_RS19675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I8755_RS19685	COG1250	3-hydroxyacyl-CoA dehydrogenase
I8755_RS19690	COG1309	transcriptional regulator
I8755_RS19695	COG1522	sequence-specific DNA binding
I8755_RS19720	COG0303	'Molybdopterin
I8755_RS19725	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I8755_RS19730	COG3321	synthase
I8755_RS19730	COG0604	alcohol dehydrogenase
I8755_RS19730	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS19745	COG0515	serine threonine protein kinase
I8755_RS19750	COG0515	serine threonine protein kinase
I8755_RS19770	COG0022	dehydrogenase e1 component
I8755_RS19775	COG0508	dehydrogenase complex catalyzes the overall conversion of
I8755_RS19790	COG2271	Major facilitator Superfamily
I8755_RS19810	COG1362	aminopeptidase activity
I8755_RS19820	COG1960	acyl-CoA dehydrogenase activity
I8755_RS19830	COG1741	Belongs to the pirin family
I8755_RS19845	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I8755_RS19860	COG1309	transcriptional regulator
I8755_RS19865	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I8755_RS19880	COG0583	DNA-binding transcription factor activity
I8755_RS19890	COG1289	transmembrane transporter activity
I8755_RS19920	COG0583	DNA-binding transcription factor activity
I8755_RS19950	COG1309	transcriptional regulator
I8755_RS19970	COG2197	response regulator
I8755_RS20020	COG0717	Belongs to the dCTP deaminase family
I8755_RS20060	COG0247	lactate metabolic process
I8755_RS20060	COG2181	nitrate reductase activity
I8755_RS20065	COG0443	Heat shock 70 kDa protein
I8755_RS20070	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I8755_RS20075	COG0484	heat shock protein binding
I8755_RS20080	COG0789	Transcriptional regulator
I8755_RS20110	COG0542	response to heat
I8755_RS20145	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I8755_RS20150	COG0191	fructose-bisphosphate aldolase activity
I8755_RS20175	COG3844	kynureninase activity
I8755_RS20190	COG4585	Histidine kinase
I8755_RS20195	COG2197	response regulator
I8755_RS20200	COG2124	cytochrome p450
I8755_RS20205	COG3559	Exporter of polyketide antibiotics
I8755_RS20210	COG1131	(ABC) transporter
I8755_RS20225	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I8755_RS20230	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I8755_RS20235	COG0515	serine threonine protein kinase
I8755_RS20235	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I8755_RS20245	COG0693	protein deglycase activity
I8755_RS20265	COG0745	RESPONSE REGULATOR receiver
I8755_RS20275	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I8755_RS20285	COG0463	Glycosyl transferase, family 2
I8755_RS20300	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I8755_RS20305	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I8755_RS20325	COG1595	DNA-templated transcription, initiation
I8755_RS20375	COG2072	flavoprotein involved in K transport
I8755_RS20400	COG0438	transferase activity, transferring glycosyl groups
I8755_RS20410	COG0728	peptidoglycan biosynthetic process
I8755_RS20420	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I8755_RS20425	COG0438	transferase activity, transferring glycosyl groups
I8755_RS20455	COG2304	oxidoreductase activity
I8755_RS20510	COG2319	Wd-40 repeat
I8755_RS20510	COG4249	Peptidase C14 caspase catalytic subunit p20
I8755_RS20525	COG0443	Heat shock 70 kDa protein
I8755_RS20540	COG0242	peptide deformylase activity
I8755_RS20605	COG1609	Transcriptional regulator
I8755_RS20630	COG1408	metallophosphoesterase
I8755_RS20640	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I8755_RS20650	COG0003	Pfam Anion-transporting ATPase
I8755_RS20675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8755_RS20700	COG2267	carboxylic ester hydrolase activity
I8755_RS20710	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I8755_RS20715	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I8755_RS20720	COG0288	reversible hydration of carbon dioxide
I8755_RS20785	COG1366	Belongs to the anti-sigma-factor antagonist family
I8755_RS20795	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
I8755_RS20805	COG2890	protein-(glutamine-N5) methyltransferase activity
I8755_RS20815	COG1754	DNA topoisomerase type I activity
I8755_RS20815	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I8755_RS20820	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I8755_RS20825	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I8755_RS20885	COG1051	belongs to the nudix hydrolase family
I8755_RS20920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I8755_RS20960	COG2197	response regulator
I8755_RS20975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I8755_RS21025	COG3629	intracellular signal transduction
I8755_RS21030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8755_RS21035	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I8755_RS21045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8755_RS21065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8755_RS21070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I8755_RS21095	COG0745	RESPONSE REGULATOR receiver
I8755_RS21100	COG5002	protein histidine kinase activity
I8755_RS21105	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I8755_RS21105	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I8755_RS21115	COG1136	(ABC) transporter
I8755_RS21125	COG1289	transmembrane transporter activity
I8755_RS21135	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I8755_RS21140	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I8755_RS21145	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I8755_RS21150	COG0254	rRNA binding
I8755_RS21160	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I8755_RS21180	COG1012	belongs to the aldehyde dehydrogenase family
I8755_RS21190	COG2318	DinB family
I8755_RS21200	COG0789	Transcriptional regulator
I8755_RS21215	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I8755_RS21220	COG2027	D-alanyl-D-alanine carboxypeptidase
I8755_RS21230	COG0037	tRNA processing
I8755_RS21245	COG0302	gtp cyclohydrolase
I8755_RS21255	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I8755_RS21260	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I8755_RS21290	COG1174	glycine betaine transport
I8755_RS21295	COG1174	glycine betaine transport
I8755_RS21320	COG0649	NAD binding
I8755_RS21335	COG2197	response regulator
I8755_RS21360	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I8755_RS21365	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I8755_RS21375	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I8755_RS21395	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I8755_RS21415	COG0739	heme binding
I8755_RS21425	COG0477	Major facilitator Superfamily
I8755_RS21430	COG2205	protein histidine kinase activity
I8755_RS21435	COG0745	RESPONSE REGULATOR receiver
I8755_RS21445	COG1595	DNA-templated transcription, initiation
I8755_RS21450	COG1194	a g-specific adenine glycosylase
I8755_RS21475	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I8755_RS21495	COG0248	Ppx GppA phosphatase
I8755_RS21500	COG1082	Xylose isomerase domain protein TIM barrel
I8755_RS21505	COG0129	dihydroxy-acid dehydratase activity
I8755_RS21525	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I8755_RS21530	COG0180	Tryptophanyl-tRNA synthetase
I8755_RS21550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I8755_RS21560	COG0123	including yeast histone deacetylase and acetoin utilization protein
I8755_RS21610	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I8755_RS21615	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I8755_RS21620	COG0181	hydroxymethylbilane synthase activity
I8755_RS21625	COG1648	precorrin-2 dehydrogenase activity
I8755_RS21625	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I8755_RS21630	COG0113	porphobilinogen synthase activity
I8755_RS21635	COG0604	alcohol dehydrogenase
I8755_RS21635	COG3321	synthase
I8755_RS21665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8755_RS21670	COG0018	arginyl-trna synthetase
I8755_RS21675	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
I8755_RS21695	COG1690	Belongs to the RtcB family
I8755_RS21710	COG1742	UPF0060 membrane protein
I8755_RS21725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8755_RS21740	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I8755_RS21745	COG0406	alpha-ribazole phosphatase activity
I8755_RS21755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8755_RS21760	COG0785	Cytochrome C biogenesis protein
I8755_RS21765	COG1333	cytochrome c biogenesis protein
I8755_RS21770	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I8755_RS21785	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I8755_RS21795	COG0163	prenyltransferase activity
I8755_RS21805	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I8755_RS21820	COG1301	dicarboxylic acid transport
I8755_RS21825	COG1309	transcriptional regulator
I8755_RS21900	COG0747	negative chemotaxis
I8755_RS21910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I8755_RS21920	COG4608	Belongs to the ABC transporter superfamily
I8755_RS21925	COG1278	Cold shock
I8755_RS21930	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
I8755_RS21945	COG1674	ftsk spoiiie
I8755_RS22000	COG2318	DinB family
I8755_RS22015	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
I8755_RS22060	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I8755_RS22070	COG2226	methyltransferase
I8755_RS22095	COG0791	NLP P60 protein
I8755_RS22095	COG1388	LysM domain
I8755_RS22095	COG3103	Sh3 type 3 domain protein
I8755_RS22105	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I8755_RS22110	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I8755_RS22115	COG0649	NAD binding
I8755_RS22125	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I8755_RS22130	COG1034	ATP synthesis coupled electron transport
I8755_RS22135	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I8755_RS22140	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I8755_RS22145	COG0839	Belongs to the complex I subunit 6 family
I8755_RS22150	COG0713	ATP synthesis coupled electron transport
I8755_RS22155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I8755_RS22165	COG1007	ATP synthesis coupled electron transport
I8755_RS22170	COG0514	ATP-dependent DNA helicase (RecQ)
I8755_RS22175	COG0179	Fumarylacetoacetate (FAA) hydrolase
I8755_RS22185	COG0561	phosphatase activity
I8755_RS22190	COG2936	dipeptidyl-peptidase activity
I8755_RS22195	COG3104	oligopeptide transport
I8755_RS22200	COG0142	geranyltranstransferase activity
I8755_RS22220	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I8755_RS22240	COG0702	epimerase
I8755_RS22245	COG1733	regulation of RNA biosynthetic process
I8755_RS22250	COG1013	pyruvate-flavodoxin oxidoreductase activity
I8755_RS22255	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I8755_RS22255	COG0674	pyruvate-flavodoxin oxidoreductase activity
I8755_RS22275	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I8755_RS22280	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I8755_RS22285	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I8755_RS22290	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I8755_RS22295	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I8755_RS22300	COG0839	Belongs to the complex I subunit 6 family
I8755_RS22305	COG0713	ATP synthesis coupled electron transport
I8755_RS22310	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I8755_RS22320	COG1007	ATP synthesis coupled electron transport
I8755_RS22325	COG0501	Belongs to the peptidase M48B family
I8755_RS22330	COG3304	Inner membrane component domain
I8755_RS22335	COG2261	transglycosylase associated protein
I8755_RS22345	COG1666	GTP binding
I8755_RS22360	COG0702	epimerase
I8755_RS22365	COG0402	S-adenosylhomocysteine deaminase activity
I8755_RS22380	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I8755_RS22385	COG2030	dehydratase
I8755_RS22395	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I8755_RS22410	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I8755_RS22415	COG0436	Aminotransferase
I8755_RS22425	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I8755_RS22435	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I8755_RS22440	COG0081	regulation of translation
I8755_RS22455	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I8755_RS22460	COG0222	ribosome binding
I8755_RS22465	COG0085	RNA polymerase activity
I8755_RS22470	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I8755_RS22485	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I8755_RS22490	COG0049	tRNA binding
I8755_RS22495	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I8755_RS22500	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I8755_RS22530	COG0051	transcription antitermination factor activity, RNA binding
I8755_RS22535	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I8755_RS22540	COG0088	Forms part of the polypeptide exit tunnel
I8755_RS22545	COG0089	rRNA binding
I8755_RS22550	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I8755_RS22555	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I8755_RS22560	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I8755_RS22565	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I8755_RS22570	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I8755_RS22575	COG0255	Belongs to the universal ribosomal protein uL29 family
I8755_RS22580	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I8755_RS22585	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I8755_RS22590	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I8755_RS22595	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I8755_RS22600	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I8755_RS22605	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I8755_RS22610	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I8755_RS22615	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I8755_RS22620	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I8755_RS22625	COG1841	ribosomal large subunit assembly
I8755_RS22630	COG0200	Binds to the 23S rRNA
I8755_RS22640	COG0563	adenylate kinase activity
I8755_RS22650	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I8755_RS22655	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I8755_RS22660	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I8755_RS22665	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I8755_RS22670	COG0202	RNA polymerase activity
I8755_RS22675	COG0203	ribosomal protein L17
I8755_RS22680	COG0101	tRNA pseudouridine synthase activity
I8755_RS22695	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I8755_RS22700	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I8755_RS22705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I8755_RS22715	COG1072	(Pantothenic acid kinase))
I8755_RS22720	COG0736	holo-[acyl-carrier-protein] synthase activity
I8755_RS22730	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I8755_RS22740	COG0802	atpase or kinase
I8755_RS22760	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I8755_RS22780	COG4941	Belongs to the sigma-70 factor family
I8755_RS22790	COG0726	polysaccharide deacetylase
I8755_RS22800	COG0459	protein refolding
I8755_RS22805	COG4221	oxidoreductase activity
I8755_RS22815	COG0583	DNA-binding transcription factor activity
I8755_RS22830	COG1595	DNA-templated transcription, initiation
I8755_RS22840	COG0516	GMP reductase activity
I8755_RS22850	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I8755_RS22865	COG0515	serine threonine protein kinase
I8755_RS22870	COG0515	serine threonine protein kinase
I8755_RS22875	COG0515	serine threonine protein kinase
I8755_RS22880	COG1012	belongs to the aldehyde dehydrogenase family
I8755_RS22915	COG0519	Catalyzes the synthesis of GMP from XMP
I8755_RS22915	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I8755_RS22950	COG2197	response regulator
I8755_RS22955	COG0791	NLP P60 protein
I8755_RS22985	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I8755_RS22985	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I8755_RS23000	COG0714	Associated with various cellular activities
I8755_RS23010	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I8755_RS23015	COG0045	succinate-CoA ligase (ADP-forming) activity
I8755_RS23045	COG0138	bifunctional purine biosynthesis protein purh
I8755_RS23055	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I8755_RS23065	COG4585	Histidine kinase
I8755_RS23070	COG2197	response regulator
I8755_RS23085	COG0039	L-malate dehydrogenase activity
I8755_RS23105	COG1476	TRANSCRIPTIONal
I8755_RS23115	COG1012	belongs to the aldehyde dehydrogenase family
I8755_RS23125	COG4175	Glycine betaine
I8755_RS23125	COG0517	IMP dehydrogenase activity
I8755_RS23130	COG4176	ABC-type proline glycine betaine transport system permease component
I8755_RS23140	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I8755_RS23145	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I8755_RS23150	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I8755_RS23155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8755_RS23165	COG0754	glutathionylspermidine amidase activity
I8755_RS23170	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I8755_RS23175	COG0180	Tryptophanyl-tRNA synthetase
I8755_RS23195	COG0671	phosphoesterase, PA-phosphatase related
I8755_RS23210	COG1295	ribonuclease BN
I8755_RS23215	COG1686	Belongs to the peptidase S11 family
I8755_RS23250	COG1053	succinate dehydrogenase
I8755_RS23260	COG2009	succinate dehydrogenase
I8755_RS23270	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I8755_RS23295	COG1595	DNA-templated transcription, initiation
I8755_RS23305	COG1595	DNA-templated transcription, initiation
I8755_RS23340	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I8755_RS23350	COG1216	Glycosyl transferase, family 2
I8755_RS23365	COG2089	acid synthase
I8755_RS23385	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I8755_RS23385	COG1473	amidohydrolase
I8755_RS23390	COG1744	ABC transporter substrate-binding protein PnrA-like
I8755_RS23395	COG1744	ABC transporter substrate-binding protein PnrA-like
I8755_RS23400	COG3845	ABC transporter
I8755_RS23405	COG4603	Belongs to the binding-protein-dependent transport system permease family
I8755_RS23410	COG1079	Belongs to the binding-protein-dependent transport system permease family
I8755_RS23440	COG2814	Major facilitator Superfamily
I8755_RS23445	COG0583	DNA-binding transcription factor activity
I8755_RS23455	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I8755_RS23480	COG2205	protein histidine kinase activity
I8755_RS23485	COG0745	RESPONSE REGULATOR receiver
I8755_RS23490	COG1595	DNA-templated transcription, initiation
I8755_RS23505	COG1012	belongs to the aldehyde dehydrogenase family
I8755_RS23510	COG1012	belongs to the aldehyde dehydrogenase family
I8755_RS23530	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I8755_RS23560	COG4770	biotin carboxylase activity
I8755_RS23570	COG0424	maF-like protein
I8755_RS23580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I8755_RS23590	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I8755_RS23595	COG1024	Enoyl-CoA hydratase
I8755_RS23605	COG2986	histidine ammonia-lyase
I8755_RS23620	COG1376	ErfK ybiS ycfS ynhG family protein
I8755_RS23630	COG1733	regulation of RNA biosynthetic process
I8755_RS23640	COG1064	alcohol dehydrogenase
I8755_RS23655	COG0740	serine-type endopeptidase activity
I8755_RS23660	COG0740	serine-type endopeptidase activity
I8755_RS23670	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I8755_RS23690	COG1595	DNA-templated transcription, initiation
I8755_RS23695	COG2255	four-way junction helicase activity
I8755_RS23700	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I8755_RS23715	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I8755_RS23725	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I8755_RS23755	COG0488	(ABC) transporter
I8755_RS23775	COG1331	Highly conserved protein containing a thioredoxin domain
I8755_RS23785	COG1309	transcriptional regulator
I8755_RS23790	COG0477	Major facilitator Superfamily
I8755_RS23800	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I8755_RS23825	COG0071	Belongs to the small heat shock protein (HSP20) family
I8755_RS23840	COG1278	Cold shock
I8755_RS23845	COG0513	Belongs to the DEAD box helicase family
I8755_RS23850	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I8755_RS23865	COG1414	Transcriptional regulator
I8755_RS23870	COG0251	oxidation-reduction process
I8755_RS23875	COG2610	gluconate transmembrane transporter activity
I8755_RS23935	COG2885	chlorophyll binding
I8755_RS23945	COG0667	Aldo Keto reductase
I8755_RS23950	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I8755_RS23955	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I8755_RS23970	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I8755_RS23975	COG0450	alkyl hydroperoxide reductase
I8755_RS23990	COG1136	(ABC) transporter
I8755_RS24000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I8755_RS24020	COG0114	fumarate hydratase activity
I8755_RS24025	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I8755_RS24025	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I8755_RS24055	COG0778	Nitroreductase
I8755_RS24060	COG1722	exodeoxyribonuclease VII activity
I8755_RS24065	COG1570	exodeoxyribonuclease VII activity
I8755_RS24070	COG1113	amino acid transport
I8755_RS24075	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I8755_RS24090	COG0012	GTP binding
I8755_RS24100	COG1131	(ABC) transporter
I8755_RS24110	COG2197	response regulator
I8755_RS24130	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I8755_RS24140	COG3629	intracellular signal transduction
I8755_RS24175	COG2814	Major facilitator Superfamily
I8755_RS24180	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I8755_RS24185	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I8755_RS24190	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I8755_RS24195	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I8755_RS24200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8755_RS24205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I8755_RS24230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I8755_RS24240	COG1012	belongs to the aldehyde dehydrogenase family
I8755_RS24270	COG0477	Major facilitator Superfamily
I8755_RS24390	COG1217	gtp-binding protein TYPA
I8755_RS24400	COG0601	transmembrane transport
I8755_RS24405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I8755_RS24410	COG0444	Belongs to the ABC transporter superfamily
I8755_RS24415	COG4608	Belongs to the ABC transporter superfamily
I8755_RS24420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8755_RS24425	COG4608	Belongs to the ABC transporter superfamily
I8755_RS24430	COG0444	Belongs to the ABC transporter superfamily
I8755_RS24435	COG0601	transmembrane transport
I8755_RS24440	COG4166	transmembrane transport
I8755_RS24445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I8755_RS24450	COG4166	transmembrane transport
I8755_RS24455	COG0601	transmembrane transport
I8755_RS24460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I8755_RS24470	COG4608	Belongs to the ABC transporter superfamily
I8755_RS24485	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I8755_RS24540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I8755_RS24550	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I8755_RS24560	COG2818	Glycosylase
I8755_RS24565	COG1024	Enoyl-CoA hydratase
I8755_RS24590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I8755_RS24595	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I8755_RS24630	COG0598	Magnesium transport protein CorA
I8755_RS24640	COG2814	Major facilitator Superfamily
I8755_RS24655	COG2095	MarC family integral membrane protein
I8755_RS24665	COG1432	Conserved Protein
I8755_RS24675	COG0513	Belongs to the DEAD box helicase family
I8755_RS24745	COG0596	Alpha beta hydrolase
I8755_RS24770	COG0210	DNA helicase
I8755_RS24775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I8755_RS24780	COG2816	NAD+ diphosphatase activity
I8755_RS24800	COG1136	(ABC) transporter
I8755_RS24895	COG3480	Lon protease (S16) C-terminal proteolytic domain
I8755_RS24905	COG1615	UPF0182 protein
I8755_RS24940	COG0753	catalase activity
I8755_RS24950	COG0483	inositol monophosphate 1-phosphatase activity
I8755_RS24960	COG2076	Multidrug Resistance protein
I8755_RS24970	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I8755_RS24980	COG2135	peptidase activity
I8755_RS24990	COG1595	DNA-templated transcription, initiation
I8755_RS24995	COG5662	AntiSigma factor
I8755_RS25000	COG2199	diguanylate cyclase activity
I8755_RS25000	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I8755_RS25015	COG0242	peptide deformylase activity
I8755_RS25025	COG2124	cytochrome p450
I8755_RS25030	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I8755_RS25055	COG1966	Carbon starvation protein
I8755_RS25060	COG2188	Transcriptional regulator
I8755_RS25065	COG2182	Extracellular solute-binding protein
I8755_RS25070	COG1175	transmembrane transport
I8755_RS25075	COG0395	ABC-type sugar transport system, permease component
I8755_RS25080	COG1472	Belongs to the glycosyl hydrolase 3 family
I8755_RS25085	COG0363	glucosamine-6-phosphate deaminase activity
I8755_RS25090	COG1309	transcriptional regulator
I8755_RS25105	COG1597	lipid kinase activity
I8755_RS25120	COG2172	sigma factor antagonist activity
I8755_RS25135	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I8755_RS25150	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I8755_RS25155	COG0142	geranyltranstransferase activity
I8755_RS25175	COG1011	Hydrolase
I8755_RS25200	COG2197	response regulator
I8755_RS25225	COG4106	trans-aconitate 2-methyltransferase activity
I8755_RS25230	COG1126	abc transporter atp-binding protein
I8755_RS25235	COG0765	amino acid transport
I8755_RS25285	COG0508	dehydrogenase complex catalyzes the overall conversion of
I8755_RS25285	COG0567	Dehydrogenase, E1 component
I8755_RS25290	COG2205	protein histidine kinase activity
I8755_RS25295	COG0745	RESPONSE REGULATOR receiver
I8755_RS25315	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I8755_RS25385	COG0768	penicillin binding
I8755_RS25390	COG0772	Belongs to the SEDS family
I8755_RS25400	COG2205	protein histidine kinase activity
I8755_RS25420	COG1793	dna ligase
I8755_RS25430	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I8755_RS25440	COG2814	Major facilitator Superfamily
I8755_RS25445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8755_RS25460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8755_RS25495	COG2186	Transcriptional regulator
I8755_RS25500	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I8755_RS25505	COG2816	NAD+ diphosphatase activity
I8755_RS25580	COG2856	Zn peptidase
I8755_RS25610	COG0019	diaminopimelate decarboxylase activity
I8755_RS25615	COG0460	homoserine dehydrogenase
I8755_RS25620	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I8755_RS25625	COG0083	homoserine kinase activity
I8755_RS25640	COG0254	rRNA binding
I8755_RS25645	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I8755_RS25650	COG2890	protein-(glutamine-N5) methyltransferase activity
I8755_RS25660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I8755_RS25665	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I8755_RS25685	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I8755_RS25690	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I8755_RS25695	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I8755_RS25700	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I8755_RS25705	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I8755_RS25710	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I8755_RS25715	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I8755_RS25730	COG2197	response regulator
I8755_RS25735	COG3850	Histidine kinase
I8755_RS25765	COG1250	3-hydroxyacyl-CoA dehydrogenase
I8755_RS25780	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
I8755_RS25835	COG0183	Belongs to the thiolase family
I8755_RS25850	COG0745	RESPONSE REGULATOR receiver
I8755_RS25855	COG2205	protein histidine kinase activity
I8755_RS25915	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I8755_RS25915	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I8755_RS25955	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I8755_RS25960	COG0280	phosphate acetyltransferase
I8755_RS25960	COG0857	belongs to the CobB CobQ family
I8755_RS25965	COG0205	6-phosphofructokinase activity
I8755_RS25975	COG0515	serine threonine protein kinase
I8755_RS25980	COG0395	ABC-type sugar transport system, permease component
I8755_RS25985	COG1175	transmembrane transport
I8755_RS25995	COG4565	transcriptional regulatory protein
I8755_RS26005	COG1301	dicarboxylic acid transport
I8755_RS26015	COG0477	Major facilitator Superfamily
I8755_RS26045	COG3118	belongs to the thioredoxin family
I8755_RS26045	COG0492	ferredoxin-NADP+ reductase activity
I8755_RS26050	COG3973	AAA domain
I8755_RS26050	COG3973	AAA domain
I8755_RS26055	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I8755_RS26070	COG0366	Alpha amylase catalytic
I8755_RS26085	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I8755_RS26085	COG0515	serine threonine protein kinase
I8755_RS26090	COG0058	SHG alpha-glucan phosphorylase activity
I8755_RS26105	COG1132	(ABC) transporter
I8755_RS26110	COG1132	(ABC) transporter
I8755_RS26130	COG1376	ErfK ybiS ycfS ynhG family protein
I8755_RS26165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I8755_RS26185	COG2186	Transcriptional regulator
I8755_RS26190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I8755_RS26195	COG1119	ATPase activity
I8755_RS26205	COG1760	l-serine dehydratase
I8755_RS26210	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I8755_RS26215	COG0509	glycine decarboxylation via glycine cleavage system
I8755_RS26220	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I8755_RS26240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I8755_RS26245	COG4166	transmembrane transport
I8755_RS26250	COG0601	transmembrane transport
I8755_RS26255	COG0444	Belongs to the ABC transporter superfamily
I8755_RS26260	COG4608	Belongs to the ABC transporter superfamily
I8755_RS26265	COG2860	membrane
I8755_RS26305	COG0482	sulfurtransferase activity
I8755_RS26320	COG4221	oxidoreductase activity
I8755_RS26330	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I8755_RS26340	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I8755_RS26345	COG0154	amidase activity
I8755_RS26355	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I8755_RS26365	COG2409	Drug exporters of the RND superfamily
I8755_RS26370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8755_RS26385	COG2197	response regulator
I8755_RS26400	COG0667	Aldo Keto reductase
I8755_RS26420	COG0440	acetolactate synthase activity
I8755_RS26425	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I8755_RS26430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I8755_RS26435	COG0477	Major facilitator Superfamily
I8755_RS26450	COG3835	regulator
I8755_RS26455	COG0506	proline dehydrogenase activity
I8755_RS26460	COG1012	belongs to the aldehyde dehydrogenase family
I8755_RS26480	COG0473	3-isopropylmalate dehydrogenase activity
I8755_RS26485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I8755_RS26500	COG0832	Belongs to the urease beta subunit family
I8755_RS26500	COG0831	urea catabolic process
I8755_RS26505	COG0804	urea catabolic process
I8755_RS26510	COG2957	Belongs to the agmatine deiminase family
I8755_RS26530	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I8755_RS26555	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I8755_RS26585	COG2018	Roadblock/LC7 domain
I8755_RS26605	COG2018	Roadblock/LC7 domain
I8755_RS26610	COG5002	protein histidine kinase activity
I8755_RS26620	COG0179	Fumarylacetoacetate (FAA) hydrolase
I8755_RS26625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I8755_RS26630	COG1011	Hydrolase
I8755_RS26670	COG1414	Transcriptional regulator
I8755_RS26675	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I8755_RS26680	COG0066	3-isopropylmalate dehydratase activity
I8755_RS26690	COG0776	regulation of translation
I8755_RS26705	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I8755_RS26710	COG1181	Belongs to the D-alanine--D-alanine ligase family
I8755_RS26730	COG0351	phosphomethylpyrimidine kinase
I8755_RS26745	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I8755_RS26750	COG1461	Dihydroxyacetone kinase
I8755_RS26760	COG0742	ribosomal rna small subunit methyltransferase
I8755_RS26765	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I8755_RS26780	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I8755_RS26785	COG0571	ribonuclease III activity
I8755_RS26790	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I8755_RS26795	COG1733	regulation of RNA biosynthetic process
I8755_RS26800	COG2340	Cysteine-rich secretory protein family
I8755_RS26805	COG1254	Belongs to the acylphosphatase family
I8755_RS26815	COG1196	nuclear chromosome segregation
I8755_RS26820	COG0477	Major facilitator Superfamily
I8755_RS26830	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I8755_RS26860	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I8755_RS26870	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I8755_RS26885	COG0228	four-way junction DNA binding
I8755_RS26890	COG1837	Belongs to the UPF0109 family
I8755_RS26895	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I8755_RS26900	COG0336	Belongs to the RNA methyltransferase TrmD family
I8755_RS26905	COG0335	large ribosomal subunit rRNA binding
I8755_RS26920	COG0681	Belongs to the peptidase S26 family
I8755_RS26930	COG1051	belongs to the nudix hydrolase family
I8755_RS26940	COG0792	nuclease activity
I8755_RS26955	COG1191	sigma factor activity
I8755_RS26965	COG4942	peptidase
I8755_RS26970	COG0052	Belongs to the universal ribosomal protein uS2 family
I8755_RS26975	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I8755_RS26980	COG0528	UMP kinase activity
I8755_RS26985	COG0233	cytoplasmic translational termination
I8755_RS26995	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I8755_RS27010	COG3842	ATPase activity
I8755_RS27040	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I8755_RS27050	COG1012	belongs to the aldehyde dehydrogenase family
I8755_RS27080	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I8755_RS27095	COG1012	belongs to the aldehyde dehydrogenase family
I8755_RS27105	COG3842	ATPase activity
I8755_RS27110	COG1176	ABC-type spermidine putrescine transport system, permease component I
I8755_RS27115	COG1177	transmembrane transport
I8755_RS27120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I8755_RS27150	COG2508	Transcriptional regulator
I8755_RS27150	COG2508	Transcriptional regulator
I8755_RS27155	COG1012	belongs to the aldehyde dehydrogenase family
I8755_RS27160	COG0300	oxidoreductase activity
I8755_RS27170	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I8755_RS27175	COG0750	zinc metalloprotease
I8755_RS27180	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I8755_RS27195	COG0442	prolyl-tRNA aminoacylation
I8755_RS27200	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
I8755_RS27215	COG0779	Required for maturation of 30S ribosomal subunits
I8755_RS27230	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I8755_RS27240	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I8755_RS27245	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I8755_RS27260	COG4608	Belongs to the ABC transporter superfamily
I8755_RS27265	COG0444	Belongs to the ABC transporter superfamily
I8755_RS27270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I8755_RS27275	COG0601	transmembrane transport
I8755_RS27280	COG4166	transmembrane transport
I8755_RS27285	COG0455	bacterial-type flagellum organization
I8755_RS27320	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I8755_RS27325	COG1185	polyribonucleotide nucleotidyltransferase activity
I8755_RS27330	COG0612	Peptidase, M16
I8755_RS27335	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I8755_RS27355	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
I8755_RS27360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I8755_RS27365	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I8755_RS27400	COG2770	Histidine kinase
I8755_RS27400	COG2208	phosphoserine phosphatase activity
I8755_RS27405	COG4999	Histidine kinase
I8755_RS27405	COG2205	protein histidine kinase activity
I8755_RS27405	COG3437	response regulator, receiver
I8755_RS27405	COG3850	Histidine kinase
I8755_RS27415	COG1674	ftsk spoiiie
I8755_RS27425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I8755_RS27435	COG1058	Belongs to the CinA family
I8755_RS27435	COG1546	Belongs to the CinA family
I8755_RS27440	COG1396	sequence-specific DNA binding
I8755_RS27445	COG0783	Belongs to the Dps family
I8755_RS27460	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I8755_RS27465	COG1201	RNA secondary structure unwinding
I8755_RS27480	COG0628	permease
I8755_RS27485	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I8755_RS27505	COG2897	thiosulfate sulfurtransferase activity
I8755_RS27520	COG0765	amino acid transport
I8755_RS27525	COG0765	amino acid transport
I8755_RS27535	COG1126	abc transporter atp-binding protein
I8755_RS27545	COG2205	protein histidine kinase activity
I8755_RS27555	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I8755_RS27570	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I8755_RS27580	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I8755_RS27585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I8755_RS27595	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I8755_RS27635	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I8755_RS27640	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I8755_RS27645	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I8755_RS27690	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I8755_RS27715	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I8755_RS27720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8755_RS27725	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8755_RS27730	COG1120	ATPase activity
I8755_RS27740	COG1132	(ABC) transporter
I8755_RS27750	COG1132	(ABC) transporter
I8755_RS27755	COG2382	esterase
I8755_RS27775	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I8755_RS27795	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I8755_RS27800	COG2186	Transcriptional regulator
I8755_RS27820	COG0187	DNA topoisomerase II activity
I8755_RS27830	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I8755_RS27835	COG4565	transcriptional regulatory protein
I8755_RS27840	COG3290	protein histidine kinase activity
I8755_RS27855	COG0372	Belongs to the citrate synthase family
I8755_RS27875	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I8755_RS27880	COG0612	Peptidase, M16
I8755_RS27895	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8755_RS27900	COG0045	succinate-CoA ligase (ADP-forming) activity
I8755_RS27915	COG1435	thymidine kinase activity
I8755_RS27950	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I8755_RS27965	COG0745	RESPONSE REGULATOR receiver
I8755_RS27970	COG2205	protein histidine kinase activity
I8755_RS27995	COG0756	dUTP diphosphatase activity
I8755_RS28015	COG1136	(ABC) transporter
I8755_RS28020	COG1136	(ABC) transporter
I8755_RS28020	COG4591	ABC-type transport system involved in lipoprotein release permease component
I8755_RS28050	COG0569	domain protein
I8755_RS28070	COG0531	amino acid
I8755_RS28075	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I8755_RS28080	COG0318	PFAM AMP-dependent synthetase and ligase
I8755_RS28100	COG0444	Belongs to the ABC transporter superfamily
I8755_RS28165	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I8755_RS28180	COG1215	transferase activity, transferring glycosyl groups
I8755_RS28190	COG4310	Domain of unknown function (DUF2172)
I8755_RS28205	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I8755_RS28215	COG0438	transferase activity, transferring glycosyl groups
I8755_RS28240	COG0367	asparagine synthase
I8755_RS28260	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I8755_RS28285	COG1533	DNA photolyase activity
I8755_RS28300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I8755_RS28320	COG0477	Major facilitator Superfamily
I8755_RS28350	COG2124	cytochrome p450
I8755_RS28390	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
I8755_RS28405	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I8755_RS28410	COG1799	cell septum assembly
I8755_RS28460	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I8755_RS28465	COG2235	arginine
I8755_RS28470	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I8755_RS28480	COG1024	Enoyl-CoA hydratase
I8755_RS28500	COG1960	acyl-CoA dehydrogenase activity
I8755_RS28525	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I8755_RS28530	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I8755_RS28585	COG1175	transmembrane transport
I8755_RS28590	COG0395	ABC-type sugar transport system, permease component
I8755_RS28595	COG2182	Extracellular solute-binding protein
I8755_RS28605	COG0395	ABC-type sugar transport system, permease component
I8755_RS28630	COG4213	ABC transporter substrate-binding protein
I8755_RS28640	COG4214	carbohydrate transport
I8755_RS28645	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I8755_RS28650	COG0531	amino acid
I8755_RS28665	COG2843	Capsule synthesis protein
I8755_RS28700	COG1024	Enoyl-CoA hydratase
I8755_RS28700	COG1250	3-hydroxyacyl-CoA dehydrogenase
I8755_RS28705	COG0183	Belongs to the thiolase family
I8755_RS28710	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I8755_RS28725	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I8755_RS28740	COG0446	pyridine nucleotide-disulphide oxidoreductase
I8755_RS28750	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I8755_RS28755	COG3253	May function as heme-dependent peroxidase
I8755_RS28760	COG0596	Alpha beta hydrolase
I8755_RS28780	COG3220	belongs to the UPF0276 family
I8755_RS28795	COG1116	anion transmembrane transporter activity
I8755_RS28820	COG0596	Alpha beta hydrolase
I8755_RS28830	COG2226	methyltransferase
I8755_RS28860	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I8755_RS28865	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I8755_RS28870	COG2234	aminopeptidase activity
I8755_RS28870	COG4935	Belongs to the peptidase S8 family
I8755_RS28875	COG1869	D-ribose catabolic process
I8755_RS28880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I8755_RS28890	COG1129	ABC transporter
I8755_RS28945	COG0443	Heat shock 70 kDa protein
I8755_RS28950	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I8755_RS28980	COG0504	CTP synthase activity
I8755_RS28990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I8755_RS29105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I8755_RS29110	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I8755_RS29130	COG0529	Catalyzes the synthesis of activated sulfate
I8755_RS29135	COG0175	sulfate reduction
I8755_RS29145	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I8755_RS29160	COG1960	acyl-CoA dehydrogenase activity
I8755_RS29190	COG0494	nUDIX hydrolase
I8755_RS29240	COG2124	cytochrome p450
I8755_RS29245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8755_RS29300	COG0028	Belongs to the TPP enzyme family
I8755_RS29325	COG1802	Transcriptional regulator
I8755_RS29335	COG3835	regulator
I8755_RS29350	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I8755_RS29355	COG2252	PERMEase
I8755_RS29400	COG0076	glutamate decarboxylase activity
I8755_RS29405	COG3594	Acyltransferase
I8755_RS29415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I8755_RS29420	COG2192	nodulation
I8755_RS29430	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I8755_RS29435	COG0859	PFAM glycosyl transferase family 9
I8755_RS29445	COG0438	transferase activity, transferring glycosyl groups
I8755_RS29450	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I8755_RS29455	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I8755_RS29455	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I8755_RS29460	COG0859	PFAM glycosyl transferase family 9
I8755_RS29470	COG4221	oxidoreductase activity
I8755_RS29475	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I8755_RS29500	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS29510	COG0753	catalase activity
I8755_RS29515	COG0542	response to heat
I8755_RS29535	COG2197	response regulator
I8755_RS29590	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I8755_RS29605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I8755_RS29695	COG0598	Magnesium transport protein CorA
I8755_RS29705	COG2197	response regulator
I8755_RS29710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I8755_RS29715	COG0318	PFAM AMP-dependent synthetase and ligase
I8755_RS29730	COG3960	tartronate-semialdehyde synthase activity
I8755_RS29735	COG0753	catalase activity
I8755_RS29740	COG2084	Dehydrogenase
I8755_RS29745	COG3622	Belongs to the hyi family
I8755_RS29765	COG2351	hydroxyisourate hydrolase activity
I8755_RS29775	COG2233	PERMEase
I8755_RS29785	COG2233	PERMEase
I8755_RS29815	COG0534	Mate efflux family protein
I8755_RS29845	COG2356	endonuclease I
I8755_RS29860	COG0588	phosphoglycerate mutase activity
I8755_RS29880	COG0436	Aminotransferase
I8755_RS29895	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I8755_RS29910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8755_RS29925	COG4585	Histidine kinase
I8755_RS29930	COG0577	efflux transmembrane transporter activity
I8755_RS29935	COG1136	(ABC) transporter
I8755_RS29940	COG1414	Transcriptional regulator
I8755_RS29945	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I8755_RS29950	COG4266	Belongs to the allantoicase family
I8755_RS29955	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS29975	COG2197	response regulator
I8755_RS29985	COG0673	inositol 2-dehydrogenase activity
I8755_RS29990	COG2188	Transcriptional regulator
I8755_RS30005	COG1172	Belongs to the binding-protein-dependent transport system permease family
I8755_RS30015	COG1940	carbohydrate kinase activity
I8755_RS30040	COG1132	(ABC) transporter
I8755_RS30050	COG2197	response regulator
I8755_RS30055	COG4585	Histidine kinase
I8755_RS30060	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I8755_RS30080	COG2197	response regulator
I8755_RS30085	COG3851	Histidine kinase
I8755_RS30090	COG1131	(ABC) transporter
I8755_RS30120	COG1126	abc transporter atp-binding protein
I8755_RS30125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I8755_RS30130	COG0765	amino acid transport
I8755_RS30135	COG0765	amino acid transport
I8755_RS30145	COG1376	ErfK ybiS ycfS ynhG family protein
I8755_RS30155	COG0405	Gamma-glutamyltransferase
I8755_RS30175	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I8755_RS30180	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I8755_RS30235	COG1140	nitrate reductase beta subunit
I8755_RS30270	COG0483	inositol monophosphate 1-phosphatase activity
I8755_RS30290	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I8755_RS30300	COG1929	Belongs to the glycerate kinase type-1 family
I8755_RS30325	COG0559	Belongs to the binding-protein-dependent transport system permease family
I8755_RS30340	COG0688	phosphatidylethanolamine metabolic process
I8755_RS30345	COG1960	acyl-CoA dehydrogenase activity
I8755_RS30355	COG2301	Belongs to the HpcH HpaI aldolase family
I8755_RS30360	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I8755_RS30360	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I8755_RS30365	COG0604	alcohol dehydrogenase
I8755_RS30375	COG1250	3-hydroxyacyl-CoA dehydrogenase
I8755_RS30410	COG2172	sigma factor antagonist activity
I8755_RS30410	COG1366	Belongs to the anti-sigma-factor antagonist family
I8755_RS30410	COG2208	phosphoserine phosphatase activity
I8755_RS30420	COG1802	Transcriptional regulator
I8755_RS30425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I8755_RS30440	COG0395	ABC-type sugar transport system, permease component
I8755_RS30460	COG1653	transport
I8755_RS30465	COG2755	lipolytic protein G-D-S-L family
I8755_RS30470	COG3866	Pectate lyase
I8755_RS30485	COG5297	Belongs to the glycosyl hydrolase family 6
I8755_RS30500	COG0395	ABC-type sugar transport system, permease component
I8755_RS30505	COG4209	transmembrane transport
I8755_RS30520	COG1501	Belongs to the glycosyl hydrolase 31 family
I8755_RS30525	COG1595	DNA-templated transcription, initiation
I8755_RS30555	COG4214	carbohydrate transport
I8755_RS30585	COG1414	Transcriptional regulator
I8755_RS30590	COG3386	PFAM SMP-30 Gluconolaconase
I8755_RS30600	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I8755_RS30605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8755_RS30620	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I8755_RS30630	COG2362	D-Aminopeptidase
I8755_RS30635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I8755_RS30645	COG1619	proteins homologs of microcin C7 resistance protein MccF
I8755_RS30670	COG0326	Molecular chaperone. Has ATPase activity
I8755_RS30705	COG1793	dna ligase
I8755_RS30705	COG3285	dna ligase
I8755_RS30770	COG0488	(ABC) transporter
I8755_RS30785	COG0248	Ppx GppA phosphatase
I8755_RS30790	COG0028	Belongs to the TPP enzyme family
I8755_RS30835	COG0531	amino acid
I8755_RS30845	COG0443	Heat shock 70 kDa protein
I8755_RS30860	COG1140	nitrate reductase beta subunit
I8755_RS30880	COG2154	pterin-4-alpha-carbinolamine dehydratase
I8755_RS30885	COG2226	methyltransferase
I8755_RS30900	COG0656	L-ascorbic acid biosynthetic process
I8755_RS30935	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I8755_RS30940	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I8755_RS30955	COG1940	carbohydrate kinase activity
I8755_RS30960	COG1129	ABC transporter
I8755_RS30965	COG1172	Belongs to the binding-protein-dependent transport system permease family
I8755_RS30970	COG1879	ABC-type sugar transport system periplasmic component
I8755_RS30975	COG0673	inositol 2-dehydrogenase activity
I8755_RS31000	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I8755_RS31045	COG3938	Belongs to the proline racemase family
I8755_RS31055	COG0446	pyridine nucleotide-disulphide oxidoreductase
I8755_RS31065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I8755_RS31070	COG2207	Transcriptional regulator
I8755_RS31075	COG2223	nitrite transmembrane transporter activity
I8755_RS31085	COG1472	Belongs to the glycosyl hydrolase 3 family
I8755_RS31090	COG1063	alcohol dehydrogenase
I8755_RS31115	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I8755_RS31130	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS31140	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I8755_RS31160	COG0583	DNA-binding transcription factor activity
I8755_RS31170	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I8755_RS31175	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I8755_RS31200	COG1404	Belongs to the peptidase S8 family
I8755_RS31240	COG1136	(ABC) transporter
I8755_RS31240	COG0577	efflux transmembrane transporter activity
I8755_RS31260	COG3246	L-lysine catabolic process to acetate
I8755_RS31265	COG1250	3-hydroxyacyl-CoA dehydrogenase
I8755_RS31275	COG0477	Major facilitator Superfamily
I8755_RS31305	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I8755_RS31320	COG4221	oxidoreductase activity
I8755_RS31320	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS31320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8755_RS31320	COG3321	synthase
I8755_RS31335	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I8755_RS31380	COG0596	Alpha beta hydrolase
I8755_RS31380	COG0508	dehydrogenase complex catalyzes the overall conversion of
I8755_RS31385	COG3243	poly(R)-hydroxyalkanoic acid synthase
I8755_RS31400	COG0604	alcohol dehydrogenase
I8755_RS31400	COG3321	synthase
I8755_RS31405	COG0604	alcohol dehydrogenase
I8755_RS31405	COG3321	synthase
I8755_RS31430	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I8755_RS31440	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I8755_RS31460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I8755_RS31470	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I8755_RS31480	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS31530	COG1324	tolerance protein
I8755_RS31590	COG1486	melibiose metabolic process
I8755_RS31605	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I8755_RS31610	COG3511	phospholipase C
I8755_RS31615	COG0525	valine-tRNA ligase activity
I8755_RS31645	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I8755_RS31650	COG1960	acyl-CoA dehydrogenase activity
I8755_RS31655	COG1960	acyl-CoA dehydrogenase activity
I8755_RS31665	COG1309	transcriptional regulator
I8755_RS31670	COG0183	Belongs to the thiolase family
I8755_RS31695	COG1024	Enoyl-CoA hydratase
I8755_RS31705	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS31710	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I8755_RS31715	COG1595	DNA-templated transcription, initiation
I8755_RS31720	COG1470	cell adhesion involved in biofilm formation
I8755_RS31730	COG1793	dna ligase
I8755_RS31830	COG1834	amidinotransferase
I8755_RS31835	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I8755_RS31840	COG0488	(ABC) transporter
I8755_RS31860	COG2268	Band 7 protein
I8755_RS31870	COG1515	deoxyribonuclease V activity
I8755_RS31880	COG3268	Saccharopine dehydrogenase
I8755_RS31885	COG1683	Conserved Protein
I8755_RS31890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I8755_RS31895	COG1960	acyl-CoA dehydrogenase activity
I8755_RS31900	COG0183	Belongs to the thiolase family
I8755_RS31905	COG1250	3-hydroxyacyl-CoA dehydrogenase
I8755_RS31905	COG1024	Enoyl-CoA hydratase
I8755_RS31920	COG1113	amino acid transport
I8755_RS31930	COG2936	dipeptidyl-peptidase activity
I8755_RS31940	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I8755_RS31950	COG0488	(ABC) transporter
I8755_RS31955	COG2183	response to ionizing radiation
I8755_RS31970	COG4977	sequence-specific DNA binding
I8755_RS31980	COG1024	Enoyl-CoA hydratase
I8755_RS31990	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I8755_RS32040	COG1134	teichoic acid transport
I8755_RS32045	COG1562	ergosterol biosynthetic process
I8755_RS32055	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I8755_RS32065	COG1657	PFAM Prenyltransferase squalene oxidase
I8755_RS32080	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I8755_RS32105	COG2365	Tyrosine phosphatase family
I8755_RS32115	COG2755	lipolytic protein G-D-S-L family
I8755_RS32150	COG0673	inositol 2-dehydrogenase activity
I8755_RS32155	COG1063	alcohol dehydrogenase
I8755_RS32160	COG0156	8-amino-7-oxononanoate synthase activity
I8755_RS32165	COG0583	DNA-binding transcription factor activity
I8755_RS32170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I8755_RS32180	COG1116	anion transmembrane transporter activity
I8755_RS32185	COG1396	sequence-specific DNA binding
I8755_RS32205	COG2267	carboxylic ester hydrolase activity
I8755_RS32225	COG3540	Alkaline phosphatase
I8755_RS32250	COG0668	transmembrane transport
I8755_RS32270	COG1175	transmembrane transport
I8755_RS32275	COG0395	ABC-type sugar transport system, permease component
I8755_RS32285	COG0673	inositol 2-dehydrogenase activity
I8755_RS32295	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS32315	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I8755_RS32330	COG0183	Belongs to the thiolase family
I8755_RS32355	COG1309	transcriptional regulator
I8755_RS32370	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS32395	COG2197	response regulator
I8755_RS32400	COG4585	Histidine kinase
I8755_RS32405	COG1136	(ABC) transporter
I8755_RS32515	COG2197	response regulator
I8755_RS32535	COG2353	YceI-like domain
I8755_RS32540	COG3655	Transcriptional regulator
I8755_RS32550	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I8755_RS32555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8755_RS32585	COG2890	protein-(glutamine-N5) methyltransferase activity
I8755_RS32635	COG1132	(ABC) transporter
I8755_RS32655	COG1063	alcohol dehydrogenase
I8755_RS32665	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I8755_RS32675	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS32755	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I8755_RS32760	COG0463	Glycosyl transferase, family 2
I8755_RS32760	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I8755_RS32800	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I8755_RS32805	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I8755_RS32845	COG1408	metallophosphoesterase
I8755_RS32895	COG0582	viral genome integration into host DNA
I8755_RS32900	COG3547	Transposase (IS116 IS110 IS902 family)
I8755_RS32975	COG0107	imidazoleglycerol-phosphate synthase activity
I8755_RS32990	COG0156	8-amino-7-oxononanoate synthase activity
I8755_RS33070	COG1484	DNA-dependent DNA replication
I8755_RS33080	COG3961	Belongs to the TPP enzyme family
I8755_RS33100	COG1228	amidohydrolase
I8755_RS33110	COG3033	Beta-eliminating lyase
I8755_RS33225	COG0159	tryptophan synthase activity
I8755_RS33350	COG0714	Associated with various cellular activities
I8755_RS33405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8755_RS33405	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I8755_RS33415	COG0730	response to heat
I8755_RS33420	COG1937	Protein conserved in bacteria
I8755_RS33565	COG1181	Belongs to the D-alanine--D-alanine ligase family
I8755_RS33585	COG0596	Alpha beta hydrolase
I8755_RS33720	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I8755_RS33805	COG3387	PFAM Glycoside hydrolase 15-related
I8755_RS33855	COG0251	oxidation-reduction process
I8755_RS33870	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I8755_RS33895	COG3458	cephalosporin-C deacetylase activity
I8755_RS33915	COG0297	glycogen (starch) synthase activity
I8755_RS33920	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I8755_RS33925	COG1172	Belongs to the binding-protein-dependent transport system permease family
I8755_RS33930	COG1172	Belongs to the binding-protein-dependent transport system permease family
I8755_RS33935	COG1129	ABC transporter
I8755_RS33940	COG1879	ABC-type sugar transport system periplasmic component
I8755_RS33945	COG1609	Transcriptional regulator
I8755_RS33950	COG3250	beta-galactosidase activity
I8755_RS33980	COG1609	Transcriptional regulator
I8755_RS33985	COG1653	transport
I8755_RS33990	COG1175	transmembrane transport
I8755_RS33995	COG0395	ABC-type sugar transport system, permease component
I8755_RS34010	COG4948	Mandelate Racemase Muconate Lactonizing
I8755_RS34025	COG0745	RESPONSE REGULATOR receiver
I8755_RS34035	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I8755_RS34050	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I8755_RS34065	COG0531	amino acid
I8755_RS34130	COG0583	DNA-binding transcription factor activity
I8755_RS34140	COG1053	succinate dehydrogenase
I8755_RS34145	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I8755_RS34175	COG3424	synthase
I8755_RS34180	COG1024	Enoyl-CoA hydratase
I8755_RS34185	COG1024	Enoyl-CoA hydratase
I8755_RS34200	COG1132	(ABC) transporter
I8755_RS34205	COG2205	protein histidine kinase activity
I8755_RS34210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8755_RS34245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8755_RS34250	COG2124	cytochrome p450
I8755_RS34255	COG2124	cytochrome p450
I8755_RS34260	COG2124	cytochrome p450
I8755_RS34280	COG1136	(ABC) transporter
I8755_RS34280	COG0577	efflux transmembrane transporter activity
I8755_RS34285	COG0577	efflux transmembrane transporter activity
I8755_RS34285	COG1136	(ABC) transporter
I8755_RS34290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8755_RS34300	COG2182	Extracellular solute-binding protein
I8755_RS34305	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I8755_RS34310	COG0121	glutamine amidotransferase
I8755_RS34330	COG1609	Transcriptional regulator
I8755_RS34335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8755_RS34350	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I8755_RS34355	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I8755_RS34385	COG1982	Orn Lys Arg decarboxylase major
I8755_RS34390	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I8755_RS34415	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS34420	COG1064	alcohol dehydrogenase
I8755_RS34440	COG4948	Mandelate Racemase Muconate Lactonizing
I8755_RS34455	COG0456	acetyltransferase
I8755_RS34480	COG2267	carboxylic ester hydrolase activity
I8755_RS34510	COG3547	Transposase (IS116 IS110 IS902 family)
I8755_RS34540	COG1960	acyl-CoA dehydrogenase activity
I8755_RS34550	COG0515	serine threonine protein kinase
I8755_RS34550	COG2815	serine threonine protein kinase
I8755_RS34560	COG0789	Transcriptional regulator
I8755_RS34565	COG2070	2-Nitropropane dioxygenase
I8755_RS34575	COG2366	antibiotic biosynthetic process
I8755_RS34580	COG0318	PFAM AMP-dependent synthetase and ligase
I8755_RS34615	COG3033	Beta-eliminating lyase
I8755_RS34625	COG2267	carboxylic ester hydrolase activity
I8755_RS34630	COG1605	Chorismate mutase
I8755_RS34640	COG1024	Enoyl-CoA hydratase
I8755_RS34730	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I8755_RS34745	COG2814	Major facilitator Superfamily
I8755_RS34755	COG4989	oxidoreductase activity
I8755_RS34765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I8755_RS34790	COG0662	Cupin 2, conserved barrel domain protein
I8755_RS34795	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I8755_RS34810	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I8755_RS34835	COG1131	(ABC) transporter
I8755_RS34855	COG1609	Transcriptional regulator
I8755_RS34865	COG1175	transmembrane transport
I8755_RS34870	COG3833	ABC-type maltose transport systems, permease component
I8755_RS34875	COG0366	Alpha amylase catalytic
I8755_RS34895	COG0181	hydroxymethylbilane synthase activity
I8755_RS34925	COG1793	dna ligase
I8755_RS34935	COG1295	ribonuclease BN
I8755_RS34940	COG0673	inositol 2-dehydrogenase activity
I8755_RS34945	COG1686	Belongs to the peptidase S11 family
I8755_RS34950	COG0386	Belongs to the glutathione peroxidase family
I8755_RS34980	COG2706	6-phosphogluconolactonase activity
I8755_RS35015	COG0435	Glutathione S-transferase
I8755_RS35030	COG1309	transcriptional regulator
I8755_RS35035	COG1132	(ABC) transporter
I8755_RS35075	COG3590	peptidase
I8755_RS35085	COG3631	Ketosteroid isomerase-related protein
I8755_RS35090	COG0702	epimerase
I8755_RS35095	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I8755_RS35115	COG0017	Asparaginyl-tRNA synthetase
I8755_RS35120	COG2197	response regulator
I8755_RS35135	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I8755_RS35135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8755_RS35150	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I8755_RS35160	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I8755_RS35165	COG0066	3-isopropylmalate dehydratase activity
I8755_RS35170	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I8755_RS35180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8755_RS35225	COG3547	Transposase (IS116 IS110 IS902 family)
I8755_RS35235	COG3424	synthase
I8755_RS35245	COG2124	cytochrome p450
I8755_RS35285	COG2249	NAD(P)H dehydrogenase (quinone) activity
I8755_RS35300	COG0823	Involved in the tonB-independent uptake of proteins
I8755_RS35305	COG0789	Transcriptional regulator
I8755_RS35310	COG1819	glycosyl
I8755_RS35315	COG0596	Alpha beta hydrolase
I8755_RS35355	COG1595	DNA-templated transcription, initiation
I8755_RS35385	COG2271	Major facilitator Superfamily
I8755_RS35400	COG1404	Belongs to the peptidase S8 family
I8755_RS35455	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I8755_RS35465	COG4106	trans-aconitate 2-methyltransferase activity
I8755_RS35470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8755_RS35475	COG1120	ATPase activity
I8755_RS35480	COG1129	ABC transporter
I8755_RS35485	COG2197	response regulator
I8755_RS35500	COG0107	imidazoleglycerol-phosphate synthase activity
I8755_RS35560	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS35565	COG1309	transcriptional regulator
I8755_RS35585	COG0778	Nitroreductase
I8755_RS35605	COG0789	Transcriptional regulator
I8755_RS35700	COG3833	ABC-type maltose transport systems, permease component
I8755_RS35705	COG1175	transmembrane transport
I8755_RS35715	COG3250	beta-galactosidase activity
I8755_RS35720	COG1609	Transcriptional regulator
I8755_RS35745	COG1595	DNA-templated transcription, initiation
I8755_RS35755	COG0583	DNA-binding transcription factor activity
I8755_RS35775	COG0477	Major facilitator Superfamily
I8755_RS35795	COG0512	Glutamine amidotransferase of anthranilate synthase
I8755_RS35800	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS35815	COG1228	amidohydrolase
I8755_RS35830	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I8755_RS35835	COG2814	Major facilitator Superfamily
I8755_RS35840	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
I8755_RS35875	COG0477	Major facilitator Superfamily
I8755_RS35905	COG1957	nucleoside hydrolase
I8755_RS35910	COG0477	Major facilitator Superfamily
I8755_RS35925	COG1960	acyl-CoA dehydrogenase activity
I8755_RS35940	COG1250	3-hydroxyacyl-CoA dehydrogenase
I8755_RS35945	COG3321	synthase
I8755_RS35945	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS35945	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8755_RS35945	COG0318	PFAM AMP-dependent synthetase and ligase
I8755_RS35945	COG0300	oxidoreductase activity
I8755_RS35955	COG4221	oxidoreductase activity
I8755_RS35955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8755_RS35955	COG0300	oxidoreductase activity
I8755_RS35955	COG3321	synthase
I8755_RS35970	COG3321	synthase
I8755_RS35970	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS35970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8755_RS35970	COG4221	oxidoreductase activity
I8755_RS35975	COG0300	oxidoreductase activity
I8755_RS35975	COG0318	PFAM AMP-dependent synthetase and ligase
I8755_RS35975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8755_RS35975	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS35975	COG3321	synthase
I8755_RS36000	COG0583	DNA-binding transcription factor activity
I8755_RS36010	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I8755_RS36045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I8755_RS36065	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I8755_RS36070	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I8755_RS36075	COG2080	2 iron, 2 sulfur cluster binding
I8755_RS36085	COG0583	DNA-binding transcription factor activity
I8755_RS36105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I8755_RS36135	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I8755_RS36140	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I8755_RS36160	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I8755_RS36190	COG0596	Alpha beta hydrolase
I8755_RS36205	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I8755_RS36215	COG2326	polyphosphate kinase activity
I8755_RS36240	COG0583	DNA-binding transcription factor activity
I8755_RS36270	COG2409	Drug exporters of the RND superfamily
I8755_RS36295	COG1012	belongs to the aldehyde dehydrogenase family
I8755_RS36300	COG1309	transcriptional regulator
I8755_RS36310	COG1366	Belongs to the anti-sigma-factor antagonist family
I8755_RS36335	COG1309	transcriptional regulator
I8755_RS36340	COG0596	Alpha beta hydrolase
I8755_RS36360	COG4977	sequence-specific DNA binding
I8755_RS36370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I8755_RS36465	COG1191	sigma factor activity
I8755_RS36470	COG2197	response regulator
I8755_RS36480	COG1131	(ABC) transporter
I8755_RS36490	COG2318	DinB family
I8755_RS36495	COG2813	Specifically methylates the guanine in position
I8755_RS36500	COG1396	sequence-specific DNA binding
I8755_RS36505	COG3250	beta-galactosidase activity
I8755_RS36520	COG4251	negative regulation of phosphorylation
I8755_RS36525	COG0784	Response regulator, receiver
I8755_RS36530	COG1191	sigma factor activity
I8755_RS36535	COG1191	sigma factor activity
I8755_RS36570	COG0328	RNA-DNA hybrid ribonuclease activity
I8755_RS36595	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I8755_RS36655	COG0640	Transcriptional regulator
I8755_RS36665	COG1278	Cold shock
I8755_RS36670	COG0513	Belongs to the DEAD box helicase family
I8755_RS36730	COG0488	(ABC) transporter
I8755_RS36780	COG0604	alcohol dehydrogenase
I8755_RS36780	COG3321	synthase
I8755_RS36785	COG3321	synthase
I8755_RS36785	COG0604	alcohol dehydrogenase
I8755_RS36795	COG2197	response regulator
I8755_RS36800	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I8755_RS36810	COG4221	oxidoreductase activity
I8755_RS36830	COG0318	PFAM AMP-dependent synthetase and ligase
I8755_RS36845	COG2175	clavaminate synthase activity
I8755_RS36850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8755_RS36850	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS36850	COG4221	oxidoreductase activity
I8755_RS36850	COG3321	synthase
I8755_RS36890	COG2205	protein histidine kinase activity
I8755_RS36895	COG0745	RESPONSE REGULATOR receiver
I8755_RS36915	COG3547	Transposase (IS116 IS110 IS902 family)
I8755_RS36955	COG0583	DNA-binding transcription factor activity
I8755_RS36960	COG2066	Belongs to the glutaminase family
I8755_RS36970	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I8755_RS36990	COG0789	Transcriptional regulator
I8755_RS36995	COG0667	Aldo Keto reductase
I8755_RS37010	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I8755_RS37015	COG2318	DinB family
I8755_RS37060	COG2409	Drug exporters of the RND superfamily
I8755_RS37070	COG1733	regulation of RNA biosynthetic process
I8755_RS37110	COG1120	ATPase activity
I8755_RS37115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I8755_RS37195	COG0456	acetyltransferase
I8755_RS37200	COG2318	DinB family
I8755_RS37230	COG0346	lactoylglutathione lyase activity
I8755_RS37280	COG0596	Alpha beta hydrolase
I8755_RS37290	COG0604	alcohol dehydrogenase
I8755_RS37345	COG0596	Alpha beta hydrolase
I8755_RS37350	COG2770	Histidine kinase
I8755_RS37350	COG2208	phosphoserine phosphatase activity
I8755_RS37410	COG1309	transcriptional regulator
I8755_RS37415	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS37420	COG0583	DNA-binding transcription factor activity
I8755_RS37425	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I8755_RS37440	COG0577	efflux transmembrane transporter activity
I8755_RS37440	COG1136	(ABC) transporter
I8755_RS37445	COG4585	Histidine kinase
I8755_RS37450	COG2197	response regulator
I8755_RS37465	COG1846	Transcriptional regulator
I8755_RS37510	COG2124	cytochrome p450
I8755_RS37515	COG0702	epimerase
I8755_RS37555	COG2070	2-Nitropropane dioxygenase
I8755_RS37565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8755_RS37600	COG0667	Aldo Keto reductase
I8755_RS37615	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I8755_RS37630	COG2197	response regulator
I8755_RS37635	COG3629	intracellular signal transduction
I8755_RS37635	COG3903	Transcriptional regulator
I8755_RS37660	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS37665	COG0318	PFAM AMP-dependent synthetase and ligase
I8755_RS37675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I8755_RS37685	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS37705	COG0604	alcohol dehydrogenase
I8755_RS37705	COG1028	Short-chain dehydrogenase reductase Sdr
I8755_RS37705	COG3321	synthase
I8755_RS37730	COG3251	PFAM MbtH domain protein
I8755_RS37740	COG3958	Transketolase
I8755_RS37745	COG3959	Transketolase, thiamine diphosphate binding domain
I8755_RS37755	COG2197	response regulator
I8755_RS37810	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I8755_RS37815	COG2175	clavaminate synthase activity
I8755_RS37920	COG1309	transcriptional regulator
I8755_RS37925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8755_RS38000	COG1595	DNA-templated transcription, initiation
I8755_RS38170	COG2815	serine threonine protein kinase
I8755_RS38170	COG0515	serine threonine protein kinase