locus-tag	class	description
SAM23877_RS00055	COG2514	catechol 2,3-dioxygenase activity
SAM23877_RS00105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SAM23877_RS00120	COG0702	epimerase
SAM23877_RS00170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SAM23877_RS00210	COG2770	Histidine kinase
SAM23877_RS00210	COG2208	phosphoserine phosphatase activity
SAM23877_RS00215	COG0596	Alpha beta hydrolase
SAM23877_RS00225	COG0831	urea catabolic process
SAM23877_RS00225	COG0832	Belongs to the urease beta subunit family
SAM23877_RS00230	COG0804	urea catabolic process
SAM23877_RS00240	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SAM23877_RS00245	COG0829	nickel cation binding
SAM23877_RS00310	COG1278	Cold shock
SAM23877_RS00325	COG1335	isochorismatase
SAM23877_RS00345	COG2208	phosphoserine phosphatase activity
SAM23877_RS00345	COG2770	Histidine kinase
SAM23877_RS00425	COG1278	Cold shock
SAM23877_RS00430	COG0513	Belongs to the DEAD box helicase family
SAM23877_RS00455	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SAM23877_RS00495	COG0494	nUDIX hydrolase
SAM23877_RS00600	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SAM23877_RS00630	COG1028	Short-chain dehydrogenase reductase Sdr
SAM23877_RS00635	COG3629	intracellular signal transduction
SAM23877_RS00635	COG3903	Transcriptional regulator
SAM23877_RS00640	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SAM23877_RS00660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SAM23877_RS00680	COG0745	RESPONSE REGULATOR receiver
SAM23877_RS00690	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SAM23877_RS00700	COG0154	amidase activity
SAM23877_RS00785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SAM23877_RS00845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SAM23877_RS00850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SAM23877_RS00865	COG3629	intracellular signal transduction
SAM23877_RS00880	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SAM23877_RS00900	COG3226	Transcriptional regulator
SAM23877_RS00920	COG1733	regulation of RNA biosynthetic process
SAM23877_RS00970	COG1115	amino acid carrier protein
SAM23877_RS01085	COG1181	Belongs to the D-alanine--D-alanine ligase family
SAM23877_RS01140	COG3547	Transposase (IS116 IS110 IS902 family)
SAM23877_RS01185	COG3335	DDE superfamily endonuclease
SAM23877_RS01205	COG0300	oxidoreductase activity
SAM23877_RS01255	COG0149	triose-phosphate isomerase activity
SAM23877_RS01280	COG2814	Major facilitator Superfamily
SAM23877_RS01285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAM23877_RS01290	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SAM23877_RS01305	COG1621	beta-fructofuranosidase activity
SAM23877_RS01310	COG0395	ABC-type sugar transport system, permease component
SAM23877_RS01315	COG1175	transmembrane transport
SAM23877_RS01325	COG1609	Transcriptional regulator
SAM23877_RS01330	COG1621	beta-fructofuranosidase activity
SAM23877_RS01365	COG0604	alcohol dehydrogenase
SAM23877_RS01385	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SAM23877_RS01395	COG1280	lysine exporter protein (LysE YggA)
SAM23877_RS01415	COG1733	regulation of RNA biosynthetic process
SAM23877_RS01430	COG1309	transcriptional regulator
SAM23877_RS01440	COG1028	Short-chain dehydrogenase reductase Sdr
SAM23877_RS01445	COG1595	DNA-templated transcription, initiation
SAM23877_RS01465	COG2197	response regulator
SAM23877_RS01470	COG4585	Histidine kinase
SAM23877_RS01550	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SAM23877_RS01555	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SAM23877_RS01575	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SAM23877_RS01580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAM23877_RS01595	COG1309	transcriptional regulator
SAM23877_RS01605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SAM23877_RS01670	COG0702	epimerase
SAM23877_RS01690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SAM23877_RS01715	COG3844	kynureninase activity
SAM23877_RS01725	COG3483	tryptophan 2,3-dioxygenase activity
SAM23877_RS01730	COG1028	Short-chain dehydrogenase reductase Sdr
SAM23877_RS01735	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SAM23877_RS01740	COG2151	metal-sulfur cluster biosynthetic enzyme
SAM23877_RS01745	COG3396	Phenylacetate-CoA oxygenase
SAM23877_RS01750	COG3460	Phenylacetate-CoA oxygenase
SAM23877_RS01755	COG3396	Phenylacetate-CoA oxygenase
SAM23877_RS01780	COG0604	alcohol dehydrogenase
SAM23877_RS01790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SAM23877_RS01860	COG2267	carboxylic ester hydrolase activity
SAM23877_RS01865	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SAM23877_RS01890	COG1278	Cold shock
SAM23877_RS01895	COG0738	Major facilitator superfamily
SAM23877_RS01900	COG3226	Transcriptional regulator
SAM23877_RS01920	COG0596	Alpha beta hydrolase
SAM23877_RS01960	COG4977	sequence-specific DNA binding
SAM23877_RS02010	COG0657	acetylesterase activity
SAM23877_RS02015	COG0667	Aldo Keto reductase
SAM23877_RS02020	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SAM23877_RS02030	COG1595	DNA-templated transcription, initiation
SAM23877_RS02090	COG0596	Alpha beta hydrolase
SAM23877_RS02100	COG1053	succinate dehydrogenase
SAM23877_RS02105	COG1595	DNA-templated transcription, initiation
SAM23877_RS02115	COG1819	glycosyl
SAM23877_RS02150	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SAM23877_RS02160	COG1609	Transcriptional regulator
SAM23877_RS02170	COG2814	Major facilitator Superfamily
SAM23877_RS02210	COG1191	sigma factor activity
SAM23877_RS02230	COG1366	Belongs to the anti-sigma-factor antagonist family
SAM23877_RS02235	COG2208	phosphoserine phosphatase activity
SAM23877_RS02235	COG2770	Histidine kinase
SAM23877_RS02255	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SAM23877_RS02285	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SAM23877_RS02290	COG2329	Antibiotic biosynthesis monooxygenase
SAM23877_RS02315	COG2610	gluconate transmembrane transporter activity
SAM23877_RS02320	COG0583	DNA-binding transcription factor activity
SAM23877_RS02325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SAM23877_RS02355	COG1012	belongs to the aldehyde dehydrogenase family
SAM23877_RS02365	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SAM23877_RS02390	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SAM23877_RS02395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAM23877_RS02415	COG0477	Major facilitator Superfamily
SAM23877_RS02460	COG3547	Transposase (IS116 IS110 IS902 family)
SAM23877_RS02520	COG3547	Transposase (IS116 IS110 IS902 family)
SAM23877_RS02550	COG4221	oxidoreductase activity
SAM23877_RS02555	COG5640	endopeptidase activity
SAM23877_RS02595	COG0110	maltose O-acetyltransferase activity
SAM23877_RS02600	COG2124	cytochrome p450
SAM23877_RS02635	COG2353	YceI-like domain
SAM23877_RS02645	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SAM23877_RS02650	COG0739	heme binding
SAM23877_RS02695	COG1609	Transcriptional regulator
SAM23877_RS02705	COG0402	S-adenosylhomocysteine deaminase activity
SAM23877_RS02710	COG2233	PERMEase
SAM23877_RS02735	COG1595	DNA-templated transcription, initiation
SAM23877_RS02755	COG2375	cellular response to nickel ion
SAM23877_RS02760	COG0346	lactoylglutathione lyase activity
SAM23877_RS02790	COG0584	glycerophosphoryl diester phosphodiesterase
SAM23877_RS02810	COG3795	YCII-related domain
SAM23877_RS02815	COG4941	Belongs to the sigma-70 factor family
SAM23877_RS02830	COG0395	ABC-type sugar transport system, permease component
SAM23877_RS02865	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SAM23877_RS02870	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SAM23877_RS02885	COG0584	glycerophosphoryl diester phosphodiesterase
SAM23877_RS02900	COG0517	IMP dehydrogenase activity
SAM23877_RS02900	COG0516	GMP reductase activity
SAM23877_RS02905	COG4585	Histidine kinase
SAM23877_RS02910	COG2197	response regulator
SAM23877_RS02915	COG1136	(ABC) transporter
SAM23877_RS02935	COG0583	DNA-binding transcription factor activity
SAM23877_RS02945	COG0702	epimerase
SAM23877_RS02950	COG2409	Drug exporters of the RND superfamily
SAM23877_RS02975	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SAM23877_RS02985	COG3226	Transcriptional regulator
SAM23877_RS02990	COG2391	methyltransferase activity
SAM23877_RS02995	COG0326	Molecular chaperone. Has ATPase activity
SAM23877_RS03000	COG2755	lipolytic protein G-D-S-L family
SAM23877_RS03005	COG4977	sequence-specific DNA binding
SAM23877_RS03030	COG2175	clavaminate synthase activity
SAM23877_RS03040	COG0395	ABC-type sugar transport system, permease component
SAM23877_RS03045	COG1175	transmembrane transport
SAM23877_RS03055	COG1609	Transcriptional regulator
SAM23877_RS03060	COG1953	Uracil, thiamine, allantoin
SAM23877_RS03090	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
SAM23877_RS03095	COG1082	Xylose isomerase domain protein TIM barrel
SAM23877_RS03100	COG1063	alcohol dehydrogenase
SAM23877_RS03110	COG0395	ABC-type sugar transport system, permease component
SAM23877_RS03115	COG0395	ABC-type sugar transport system, permease component
SAM23877_RS03150	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SAM23877_RS03155	COG2151	metal-sulfur cluster biosynthetic enzyme
SAM23877_RS03160	COG3396	Phenylacetate-CoA oxygenase
SAM23877_RS03165	COG3460	Phenylacetate-CoA oxygenase
SAM23877_RS03170	COG3396	Phenylacetate-CoA oxygenase
SAM23877_RS03175	COG2050	protein possibly involved in aromatic compounds catabolism
SAM23877_RS03225	COG5640	endopeptidase activity
SAM23877_RS03230	COG1119	ATPase activity
SAM23877_RS03235	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SAM23877_RS03240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SAM23877_RS03250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAM23877_RS03285	COG1335	isochorismatase
SAM23877_RS03360	COG0583	DNA-binding transcription factor activity
SAM23877_RS03375	COG2814	Major facilitator Superfamily
SAM23877_RS03385	COG0583	DNA-binding transcription factor activity
SAM23877_RS03390	COG5640	endopeptidase activity
SAM23877_RS03410	COG1017	nitric oxide dioxygenase activity
SAM23877_RS03410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SAM23877_RS03415	COG1959	2 iron, 2 sulfur cluster binding
SAM23877_RS03475	COG1609	Transcriptional regulator
SAM23877_RS03480	COG4209	transmembrane transport
SAM23877_RS03485	COG0395	ABC-type sugar transport system, permease component
SAM23877_RS03505	COG0110	maltose O-acetyltransferase activity
SAM23877_RS03530	COG1120	ATPase activity
SAM23877_RS03580	COG1028	Short-chain dehydrogenase reductase Sdr
SAM23877_RS03605	COG0475	glutathione-regulated potassium exporter activity
SAM23877_RS03630	COG1131	(ABC) transporter
SAM23877_RS03635	COG0142	geranyltranstransferase activity
SAM23877_RS03645	COG2208	phosphoserine phosphatase activity
SAM23877_RS03645	COG2770	Histidine kinase
SAM23877_RS03670	COG0456	acetyltransferase
SAM23877_RS03710	COG0753	catalase activity
SAM23877_RS03740	COG0009	L-threonylcarbamoyladenylate synthase
SAM23877_RS03775	COG2207	Transcriptional regulator
SAM23877_RS03785	COG2223	nitrite transmembrane transporter activity
SAM23877_RS03805	COG3285	dna ligase
SAM23877_RS03805	COG1793	dna ligase
SAM23877_RS03815	COG0181	hydroxymethylbilane synthase activity
SAM23877_RS03855	COG0366	Alpha amylase catalytic
SAM23877_RS03870	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SAM23877_RS03875	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SAM23877_RS03905	COG5002	protein histidine kinase activity
SAM23877_RS03905	COG2205	protein histidine kinase activity
SAM23877_RS03905	COG0784	Response regulator, receiver
SAM23877_RS03920	COG1366	Belongs to the anti-sigma-factor antagonist family
SAM23877_RS03925	COG1366	Belongs to the anti-sigma-factor antagonist family
SAM23877_RS03930	COG2172	sigma factor antagonist activity
SAM23877_RS03945	COG1252	NADH dehydrogenase
SAM23877_RS03985	COG1982	Orn Lys Arg decarboxylase major
SAM23877_RS04035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SAM23877_RS04070	COG2197	response regulator
SAM23877_RS04075	COG2340	Cysteine-rich secretory protein family
SAM23877_RS04100	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SAM23877_RS04100	COG0515	serine threonine protein kinase
SAM23877_RS04125	COG0667	Aldo Keto reductase
SAM23877_RS04135	COG0328	RNA-DNA hybrid ribonuclease activity
SAM23877_RS04150	COG0740	serine-type endopeptidase activity
SAM23877_RS04155	COG0740	serine-type endopeptidase activity
SAM23877_RS04165	COG1191	sigma factor activity
SAM23877_RS04210	COG0667	Aldo Keto reductase
SAM23877_RS04215	COG0583	DNA-binding transcription factor activity
SAM23877_RS04225	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SAM23877_RS04230	COG0346	lactoylglutathione lyase activity
SAM23877_RS04240	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SAM23877_RS04245	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SAM23877_RS04250	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SAM23877_RS04265	COG1012	belongs to the aldehyde dehydrogenase family
SAM23877_RS04275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAM23877_RS04280	COG0431	NADPH-dependent FMN reductase
SAM23877_RS04320	COG0673	inositol 2-dehydrogenase activity
SAM23877_RS04360	COG0318	PFAM AMP-dependent synthetase and ligase
SAM23877_RS04365	COG2366	antibiotic biosynthetic process
SAM23877_RS04370	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SAM23877_RS04385	COG0515	serine threonine protein kinase
SAM23877_RS04415	COG2205	protein histidine kinase activity
SAM23877_RS04420	COG0745	RESPONSE REGULATOR receiver
SAM23877_RS04450	COG1609	Transcriptional regulator
SAM23877_RS04460	COG1556	Lactate utilization protein
SAM23877_RS04465	COG1139	Iron-sulfur cluster binding protein
SAM23877_RS04470	COG0247	lactate metabolic process
SAM23877_RS04475	COG1070	Carbohydrate kinase
SAM23877_RS04480	COG3347	Dehydrogenase
SAM23877_RS04480	COG1028	Short-chain dehydrogenase reductase Sdr
SAM23877_RS04490	COG1129	ABC transporter
SAM23877_RS04495	COG1172	Belongs to the binding-protein-dependent transport system permease family
SAM23877_RS04515	COG1609	Transcriptional regulator
SAM23877_RS04530	COG1733	regulation of RNA biosynthetic process
SAM23877_RS04545	COG2376	Dihydroxyacetone kinase
SAM23877_RS04550	COG1461	Dihydroxyacetone kinase
SAM23877_RS04565	COG1028	Short-chain dehydrogenase reductase Sdr
SAM23877_RS04590	COG1902	pentaerythritol trinitrate reductase activity
SAM23877_RS04590	COG0446	pyridine nucleotide-disulphide oxidoreductase
SAM23877_RS04610	COG2890	protein-(glutamine-N5) methyltransferase activity
SAM23877_RS04620	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SAM23877_RS04635	COG3458	cephalosporin-C deacetylase activity
SAM23877_RS04640	COG2188	Transcriptional regulator
SAM23877_RS04645	COG2226	methyltransferase
SAM23877_RS04660	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SAM23877_RS04665	COG1686	Belongs to the peptidase S11 family
SAM23877_RS04675	COG1968	undecaprenyl-diphosphatase activity
SAM23877_RS04680	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SAM23877_RS04685	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SAM23877_RS04690	COG1846	Transcriptional regulator
SAM23877_RS04715	COG0137	argininosuccinate synthase activity
SAM23877_RS04725	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SAM23877_RS04745	COG1472	Belongs to the glycosyl hydrolase 3 family
SAM23877_RS04755	COG1175	transmembrane transport
SAM23877_RS04760	COG1653	transport
SAM23877_RS04765	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SAM23877_RS04765	COG3291	Pkd domain containing protein
SAM23877_RS04815	COG1674	ftsk spoiiie
SAM23877_RS04825	COG0464	growth
SAM23877_RS04870	COG3250	beta-galactosidase activity
SAM23877_RS04875	COG0395	ABC-type sugar transport system, permease component
SAM23877_RS04885	COG2182	Extracellular solute-binding protein
SAM23877_RS04895	COG1609	Transcriptional regulator
SAM23877_RS04915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SAM23877_RS04930	COG0179	Fumarylacetoacetate (FAA) hydrolase
SAM23877_RS04940	COG1028	Short-chain dehydrogenase reductase Sdr
SAM23877_RS04955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SAM23877_RS04970	COG1846	Transcriptional regulator
SAM23877_RS04985	COG1028	Short-chain dehydrogenase reductase Sdr
SAM23877_RS05005	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SAM23877_RS05010	COG0463	Glycosyl transferase, family 2
SAM23877_RS05045	COG1349	DNA-binding transcription factor activity
SAM23877_RS05080	COG1940	carbohydrate kinase activity
SAM23877_RS05090	COG2813	Specifically methylates the guanine in position
SAM23877_RS05095	COG0191	fructose-bisphosphate aldolase activity
SAM23877_RS05100	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SAM23877_RS05150	COG0783	Belongs to the Dps family
SAM23877_RS05165	COG1501	Belongs to the glycosyl hydrolase 31 family
SAM23877_RS05170	COG2182	Extracellular solute-binding protein
SAM23877_RS05175	COG1175	transmembrane transport
SAM23877_RS05180	COG0395	ABC-type sugar transport system, permease component
SAM23877_RS05185	COG2723	6-phospho-beta-galactosidase activity
SAM23877_RS05210	COG2197	response regulator
SAM23877_RS05215	COG4585	Histidine kinase
SAM23877_RS05230	COG0445	tRNA wobble uridine modification
SAM23877_RS05245	COG1660	Displays ATPase and GTPase activities
SAM23877_RS05275	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SAM23877_RS05295	COG0204	Acyl-transferase
SAM23877_RS05320	COG0584	glycerophosphoryl diester phosphodiesterase
SAM23877_RS05360	COG0671	phosphoesterase, PA-phosphatase related
SAM23877_RS05390	COG0640	Transcriptional regulator
SAM23877_RS05395	COG1902	pentaerythritol trinitrate reductase activity
SAM23877_RS05410	COG1960	acyl-CoA dehydrogenase activity
SAM23877_RS05420	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SAM23877_RS05485	COG4221	oxidoreductase activity
SAM23877_RS05495	COG0726	polysaccharide deacetylase
SAM23877_RS05505	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SAM23877_RS05510	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SAM23877_RS05515	COG2080	2 iron, 2 sulfur cluster binding
SAM23877_RS05525	COG4565	transcriptional regulatory protein
SAM23877_RS05530	COG3290	protein histidine kinase activity
SAM23877_RS05555	COG0432	Pfam Uncharacterised protein family UPF0047
SAM23877_RS05560	COG2072	flavoprotein involved in K transport
SAM23877_RS05570	COG1132	(ABC) transporter
SAM23877_RS05590	COG1132	(ABC) transporter
SAM23877_RS05600	COG0254	rRNA binding
SAM23877_RS05615	COG1946	Acyl-CoA thioesterase
SAM23877_RS05625	COG2018	Roadblock/LC7 domain
SAM23877_RS05700	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SAM23877_RS05710	COG2115	Belongs to the xylose isomerase family
SAM23877_RS05715	COG1070	Carbohydrate kinase
SAM23877_RS05720	COG1940	carbohydrate kinase activity
SAM23877_RS05720	COG1846	Transcriptional regulator
SAM23877_RS05740	COG1012	belongs to the aldehyde dehydrogenase family
SAM23877_RS05750	COG0592	DNA-directed DNA polymerase activity
SAM23877_RS05790	COG0477	Major facilitator Superfamily
SAM23877_RS05815	COG1960	acyl-CoA dehydrogenase activity
SAM23877_RS05820	COG1960	acyl-CoA dehydrogenase activity
SAM23877_RS05830	COG3800	Transcriptional regulator
SAM23877_RS05830	COG1396	sequence-specific DNA binding
SAM23877_RS05840	COG1793	dna ligase
SAM23877_RS05850	COG1012	belongs to the aldehyde dehydrogenase family
SAM23877_RS05860	COG2124	cytochrome p450
SAM23877_RS05865	COG1960	acyl-CoA dehydrogenase activity
SAM23877_RS05875	COG0242	peptide deformylase activity
SAM23877_RS05885	COG3442	glutamine amidotransferase
SAM23877_RS05890	COG0205	6-phosphofructokinase activity
SAM23877_RS05900	COG3275	phosphorelay sensor kinase activity
SAM23877_RS05905	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SAM23877_RS05915	COG3279	Response regulator of the LytR AlgR family
SAM23877_RS05920	COG1522	sequence-specific DNA binding
SAM23877_RS05925	COG1834	amidinotransferase
SAM23877_RS05930	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SAM23877_RS05965	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SAM23877_RS05970	COG3903	Transcriptional regulator
SAM23877_RS05970	COG3629	intracellular signal transduction
SAM23877_RS05995	COG0829	nickel cation binding
SAM23877_RS06000	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SAM23877_RS06010	COG0804	urea catabolic process
SAM23877_RS06015	COG0832	Belongs to the urease beta subunit family
SAM23877_RS06020	COG0831	urea catabolic process
SAM23877_RS06025	COG1309	transcriptional regulator
SAM23877_RS06045	COG0740	serine-type endopeptidase activity
SAM23877_RS06080	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SAM23877_RS06085	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SAM23877_RS06090	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SAM23877_RS06095	COG2226	methyltransferase
SAM23877_RS06100	COG0456	acetyltransferase
SAM23877_RS06125	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SAM23877_RS06130	COG3663	DNA glycosylase
SAM23877_RS06150	COG4585	Histidine kinase
SAM23877_RS06155	COG2197	response regulator
SAM23877_RS06160	COG1940	carbohydrate kinase activity
SAM23877_RS06165	COG2188	Transcriptional regulator
SAM23877_RS06170	COG1595	DNA-templated transcription, initiation
SAM23877_RS06205	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SAM23877_RS06210	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SAM23877_RS06220	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SAM23877_RS06220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SAM23877_RS06260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SAM23877_RS06275	COG0626	cystathionine gamma-synthase activity
SAM23877_RS06290	COG1028	Short-chain dehydrogenase reductase Sdr
SAM23877_RS06305	COG1522	sequence-specific DNA binding
SAM23877_RS06310	COG0419	ATPase involved in DNA repair
SAM23877_RS06315	COG0420	3'-5' exonuclease activity
SAM23877_RS06320	COG1739	Uncharacterized protein family UPF0029
SAM23877_RS06325	COG0215	cysteine-tRNA ligase activity
SAM23877_RS06330	COG1832	CoA-binding protein
SAM23877_RS06350	COG0110	maltose O-acetyltransferase activity
SAM23877_RS06380	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SAM23877_RS06395	COG1968	undecaprenyl-diphosphatase activity
SAM23877_RS06400	COG1028	Short-chain dehydrogenase reductase Sdr
SAM23877_RS06405	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SAM23877_RS06425	COG2318	DinB family
SAM23877_RS06440	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SAM23877_RS06475	COG0723	plastoquinol--plastocyanin reductase activity
SAM23877_RS06490	COG0697	spore germination
SAM23877_RS06530	COG0384	phenazine biosynthesis protein PhzF
SAM23877_RS06560	COG0725	ABC transporter, periplasmic molybdate-binding protein
SAM23877_RS06580	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SAM23877_RS06580	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SAM23877_RS06590	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SAM23877_RS06610	COG1716	ATPase activity
SAM23877_RS06630	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SAM23877_RS06660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SAM23877_RS06670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SAM23877_RS06685	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SAM23877_RS06695	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SAM23877_RS06700	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SAM23877_RS06715	COG2018	Roadblock/LC7 domain
SAM23877_RS06750	COG2814	Major facilitator Superfamily
SAM23877_RS06755	COG4336	lyase activity
SAM23877_RS06760	COG0438	transferase activity, transferring glycosyl groups
SAM23877_RS06765	COG0438	transferase activity, transferring glycosyl groups
SAM23877_RS06795	COG2364	Membrane
SAM23877_RS06805	COG2270	Major facilitator Superfamily
SAM23877_RS06815	COG3030	protein affecting phage T7 exclusion by the F plasmid
SAM23877_RS06820	COG1216	Glycosyl transferase, family 2
SAM23877_RS06845	COG1960	acyl-CoA dehydrogenase activity
SAM23877_RS06890	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SAM23877_RS06895	COG0140	phosphoribosyl-ATP diphosphatase activity
SAM23877_RS06900	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SAM23877_RS06905	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SAM23877_RS06905	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SAM23877_RS06910	COG3201	nicotinamide mononucleotide transporter
SAM23877_RS06935	COG1940	carbohydrate kinase activity
SAM23877_RS06940	COG2223	nitrite transmembrane transporter activity
SAM23877_RS06950	COG2233	PERMEase
SAM23877_RS06975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SAM23877_RS06990	COG0531	amino acid
SAM23877_RS07005	COG2390	Transcriptional regulator
SAM23877_RS07010	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SAM23877_RS07020	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SAM23877_RS07035	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SAM23877_RS07045	COG1758	RNA polymerase activity
SAM23877_RS07050	COG0194	GDP metabolic process
SAM23877_RS07060	COG0284	orotidine-5'-phosphate decarboxylase activity
SAM23877_RS07065	COG0167	dihydroorotate dehydrogenase activity
SAM23877_RS07070	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SAM23877_RS07075	COG0505	Belongs to the CarA family
SAM23877_RS07085	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SAM23877_RS07090	COG0540	Belongs to the ATCase OTCase family
SAM23877_RS07095	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SAM23877_RS07105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SAM23877_RS07110	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SAM23877_RS07115	COG0006	proline dipeptidase activity
SAM23877_RS07125	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SAM23877_RS07130	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SAM23877_RS07135	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SAM23877_RS07140	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SAM23877_RS07145	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SAM23877_RS07150	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SAM23877_RS07155	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SAM23877_RS07175	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SAM23877_RS07190	COG0124	histidyl-tRNA synthetase
SAM23877_RS07200	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SAM23877_RS07205	COG1196	nuclear chromosome segregation
SAM23877_RS07210	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SAM23877_RS07215	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SAM23877_RS07220	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SAM23877_RS07225	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SAM23877_RS07235	COG2255	four-way junction helicase activity
SAM23877_RS07240	COG0632	four-way junction helicase activity
SAM23877_RS07245	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SAM23877_RS07250	COG0217	transcriptional regulatory protein
SAM23877_RS07255	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SAM23877_RS07260	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SAM23877_RS07270	COG0438	transferase activity, transferring glycosyl groups
SAM23877_RS07275	COG1560	Kdo2-lipid A biosynthetic process
SAM23877_RS07280	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SAM23877_RS07300	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SAM23877_RS07315	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SAM23877_RS07340	COG0395	ABC-type sugar transport system, permease component
SAM23877_RS07345	COG1175	transmembrane transport
SAM23877_RS07400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SAM23877_RS07455	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SAM23877_RS07455	COG1648	precorrin-2 dehydrogenase activity
SAM23877_RS07460	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SAM23877_RS07480	COG2011	ABC-type metal ion transport system permease component
SAM23877_RS07485	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SAM23877_RS07515	COG0584	glycerophosphoryl diester phosphodiesterase
SAM23877_RS07520	COG0204	Acyl-transferase
SAM23877_RS07520	COG0318	PFAM AMP-dependent synthetase and ligase
SAM23877_RS07525	COG0477	Major facilitator Superfamily
SAM23877_RS07540	COG0165	Argininosuccinate lyase
SAM23877_RS07570	COG1438	arginine binding
SAM23877_RS07575	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SAM23877_RS07580	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SAM23877_RS07585	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SAM23877_RS07590	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SAM23877_RS07625	COG0697	spore germination
SAM23877_RS07635	COG1649	PFAM Uncharacterised BCR, COG1649
SAM23877_RS07660	COG0072	phenylalanine-tRNA ligase activity
SAM23877_RS07660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SAM23877_RS07665	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SAM23877_RS07670	COG5002	protein histidine kinase activity
SAM23877_RS07675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SAM23877_RS07680	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SAM23877_RS07685	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SAM23877_RS07690	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SAM23877_RS07735	COG1028	Short-chain dehydrogenase reductase Sdr
SAM23877_RS07740	COG1012	belongs to the aldehyde dehydrogenase family
SAM23877_RS07745	COG0174	glutamine synthetase
SAM23877_RS07755	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SAM23877_RS07780	COG4176	ABC-type proline glycine betaine transport system permease component
SAM23877_RS07785	COG4175	Glycine betaine
SAM23877_RS07785	COG0517	IMP dehydrogenase activity
SAM23877_RS07790	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SAM23877_RS07805	COG0564	pseudouridine synthase activity
SAM23877_RS07840	COG0805	protein transport
SAM23877_RS07845	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SAM23877_RS07865	COG2378	regulation of single-species biofilm formation
SAM23877_RS07875	COG0545	Peptidyl-prolyl cis-trans isomerase
SAM23877_RS07880	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SAM23877_RS07890	COG1609	Transcriptional regulator
SAM23877_RS07895	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SAM23877_RS07900	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SAM23877_RS07910	COG4122	O-methyltransferase activity
SAM23877_RS07915	COG1222	aaa ATPase
SAM23877_RS07935	COG1994	Peptidase M50
SAM23877_RS07935	COG0517	IMP dehydrogenase activity
SAM23877_RS07945	COG2197	response regulator
SAM23877_RS07950	COG4166	transmembrane transport
SAM23877_RS07960	COG0646	methionine synthase
SAM23877_RS07960	COG1410	methionine synthase
SAM23877_RS07965	COG1414	Transcriptional regulator
SAM23877_RS07970	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SAM23877_RS07975	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SAM23877_RS07980	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SAM23877_RS07985	COG2186	Transcriptional regulator
SAM23877_RS07995	COG0215	cysteine-tRNA ligase activity
SAM23877_RS08010	COG0406	alpha-ribazole phosphatase activity
SAM23877_RS08015	COG0598	Magnesium transport protein CorA
SAM23877_RS08025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAM23877_RS08030	COG0667	Aldo Keto reductase
SAM23877_RS08070	COG3012	SEC-C Motif Domain Protein
SAM23877_RS08075	COG2186	Transcriptional regulator
SAM23877_RS08080	COG3265	gluconokinase activity
SAM23877_RS08105	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SAM23877_RS08110	COG2149	membrane
SAM23877_RS08145	COG0318	PFAM AMP-dependent synthetase and ligase
SAM23877_RS08155	COG3876	Protein conserved in bacteria
SAM23877_RS08195	COG1960	acyl-CoA dehydrogenase activity
SAM23877_RS08205	COG0640	Transcriptional regulator
SAM23877_RS08225	COG3842	ATPase activity
SAM23877_RS08235	COG2851	Citrate transporter
SAM23877_RS08240	COG0243	molybdopterin cofactor binding
SAM23877_RS08245	COG1309	transcriptional regulator
SAM23877_RS08255	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
SAM23877_RS08260	COG2188	Transcriptional regulator
SAM23877_RS08280	COG1595	DNA-templated transcription, initiation
SAM23877_RS08300	COG0515	serine threonine protein kinase
SAM23877_RS08300	COG2815	serine threonine protein kinase
SAM23877_RS08305	COG2755	lipolytic protein G-D-S-L family
SAM23877_RS08310	COG0463	Glycosyl transferase, family 2
SAM23877_RS08335	COG1725	Transcriptional regulator
SAM23877_RS08350	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SAM23877_RS08350	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SAM23877_RS08370	COG0662	Cupin 2, conserved barrel domain protein
SAM23877_RS08370	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SAM23877_RS08380	COG0587	DNA-directed DNA polymerase activity
SAM23877_RS08410	COG1799	cell septum assembly
SAM23877_RS08415	COG1960	acyl-CoA dehydrogenase activity
SAM23877_RS08420	COG0477	Major facilitator Superfamily
SAM23877_RS08430	COG0671	phosphoesterase, PA-phosphatase related
SAM23877_RS08455	COG1160	GTP binding
SAM23877_RS08465	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SAM23877_RS08490	COG3541	Predicted nucleotidyltransferase
SAM23877_RS08505	COG1187	pseudouridine synthase activity
SAM23877_RS08510	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SAM23877_RS08515	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SAM23877_RS08530	COG0686	Belongs to the AlaDH PNT family
SAM23877_RS08540	COG0494	nUDIX hydrolase
SAM23877_RS08545	COG0504	CTP synthase activity
SAM23877_RS08550	COG3387	PFAM Glycoside hydrolase 15-related
SAM23877_RS08580	COG2208	phosphoserine phosphatase activity
SAM23877_RS08580	COG2770	Histidine kinase
SAM23877_RS08595	COG0497	DNA recombination
SAM23877_RS08600	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SAM23877_RS08620	COG1120	ATPase activity
SAM23877_RS08625	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAM23877_RS08630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAM23877_RS08635	COG0647	UMP catabolic process
SAM23877_RS08665	COG2094	Belongs to the DNA glycosylase MPG family
SAM23877_RS08675	COG1881	PFAM PEBP family protein
SAM23877_RS08695	COG1119	ATPase activity
SAM23877_RS08710	COG2197	response regulator
SAM23877_RS08715	COG4585	Histidine kinase
SAM23877_RS08720	COG4221	oxidoreductase activity
SAM23877_RS08725	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SAM23877_RS08735	COG1716	ATPase activity
SAM23877_RS08735	COG0842	Transport permease protein
SAM23877_RS08735	COG1131	(ABC) transporter
SAM23877_RS08745	COG3830	Belongs to the UPF0237 family
SAM23877_RS08745	COG0560	Phosphoserine phosphatase
SAM23877_RS08750	COG0588	phosphoglycerate mutase activity
SAM23877_RS08765	COG2186	Transcriptional regulator
SAM23877_RS08780	COG1028	Short-chain dehydrogenase reductase Sdr
SAM23877_RS08795	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SAM23877_RS08815	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SAM23877_RS08820	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SAM23877_RS08835	COG1404	Belongs to the peptidase S8 family
SAM23877_RS08840	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SAM23877_RS08850	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SAM23877_RS08865	COG3387	PFAM Glycoside hydrolase 15-related
SAM23877_RS08905	COG1024	Enoyl-CoA hydratase
SAM23877_RS08915	COG0488	(ABC) transporter
SAM23877_RS08935	COG0235	Class ii aldolase
SAM23877_RS08950	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SAM23877_RS08955	COG1492	cobalamin metabolic process
SAM23877_RS08975	COG1797	cobyrinic acid a,c-diamide synthase activity
SAM23877_RS09010	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
SAM23877_RS09035	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SAM23877_RS09040	COG0456	acetyltransferase
SAM23877_RS09045	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SAM23877_RS09050	COG1917	Cupin 2, conserved barrel domain protein
SAM23877_RS09055	COG5285	phytanoyl-CoA dioxygenase
SAM23877_RS09085	COG1414	Transcriptional regulator
SAM23877_RS09100	COG1595	DNA-templated transcription, initiation
SAM23877_RS09115	COG4677	pectinesterase activity
SAM23877_RS09120	COG3866	Pectate lyase
SAM23877_RS09125	COG2755	lipolytic protein G-D-S-L family
SAM23877_RS09140	COG3507	Belongs to the glycosyl hydrolase 43 family
SAM23877_RS09155	COG0395	ABC-type sugar transport system, permease component
SAM23877_RS09175	COG1802	Transcriptional regulator
SAM23877_RS09195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SAM23877_RS09200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SAM23877_RS09205	COG1349	DNA-binding transcription factor activity
SAM23877_RS09220	COG0395	ABC-type sugar transport system, permease component
SAM23877_RS09225	COG1063	alcohol dehydrogenase
SAM23877_RS09235	COG1309	transcriptional regulator
SAM23877_RS09275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SAM23877_RS09285	COG2171	N-acyltransferase activity
SAM23877_RS09290	COG3226	Transcriptional regulator
SAM23877_RS09295	COG2076	Multidrug Resistance protein
SAM23877_RS09300	COG2151	metal-sulfur cluster biosynthetic enzyme
SAM23877_RS09305	COG0822	iron-sulfur transferase activity
SAM23877_RS09310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SAM23877_RS09315	COG0396	ATPase activity
SAM23877_RS09325	COG0719	Fe-S assembly protein
SAM23877_RS09340	COG2746	aminoglycoside 3-N-acetyltransferase activity
SAM23877_RS09355	COG1612	heme a metabolic process
SAM23877_RS09370	COG0109	protoheme IX farnesyltransferase activity
SAM23877_RS09380	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SAM23877_RS09395	COG0363	glucosamine-6-phosphate deaminase activity
SAM23877_RS09400	COG0395	ABC-type sugar transport system, permease component
SAM23877_RS09405	COG1175	transmembrane transport
SAM23877_RS09410	COG1653	transport
SAM23877_RS09415	COG0366	Alpha amylase catalytic
SAM23877_RS09420	COG1653	transport
SAM23877_RS09425	COG1695	Transcriptional regulator
SAM23877_RS09430	COG1136	(ABC) transporter
SAM23877_RS09440	COG0166	Belongs to the GPI family
SAM23877_RS09450	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SAM23877_RS09455	COG0149	triose-phosphate isomerase activity
SAM23877_RS09460	COG0126	phosphoglycerate kinase activity
SAM23877_RS09465	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SAM23877_RS09475	COG1481	regulation of sporulation
SAM23877_RS09480	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SAM23877_RS09485	COG1660	Displays ATPase and GTPase activities
SAM23877_RS09490	COG0322	excinuclease ABC activity
SAM23877_RS09505	COG1609	Transcriptional regulator
SAM23877_RS09525	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SAM23877_RS09540	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SAM23877_RS09545	COG1619	proteins homologs of microcin C7 resistance protein MccF
SAM23877_RS09550	COG0387	Pfam Sodium calcium exchanger
SAM23877_RS09570	COG0556	nucleotide-excision repair
SAM23877_RS09580	COG0584	glycerophosphoryl diester phosphodiesterase
SAM23877_RS09585	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SAM23877_RS09595	COG2313	pseudouridylate synthase activity
SAM23877_RS09600	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SAM23877_RS09600	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SAM23877_RS09605	COG2226	methyltransferase
SAM23877_RS09610	COG0598	Magnesium transport protein CorA
SAM23877_RS09670	COG0402	S-adenosylhomocysteine deaminase activity
SAM23877_RS09720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SAM23877_RS09740	COG0237	dephospho-CoA kinase activity
SAM23877_RS09755	COG2226	methyltransferase
SAM23877_RS09760	COG1643	Atp-dependent helicase
SAM23877_RS09790	COG2050	protein possibly involved in aromatic compounds catabolism
SAM23877_RS09850	COG0737	Belongs to the 5'-nucleotidase family
SAM23877_RS09870	COG0287	Prephenate dehydrogenase
SAM23877_RS09870	COG1605	Chorismate mutase
SAM23877_RS09890	COG2304	oxidoreductase activity
SAM23877_RS09910	COG0067	glutamate synthase
SAM23877_RS09910	COG0069	glutamate synthase activity
SAM23877_RS09910	COG0070	glutamate synthase
SAM23877_RS09940	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SAM23877_RS09945	COG2301	Belongs to the HpcH HpaI aldolase family
SAM23877_RS09950	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SAM23877_RS09960	COG0159	tryptophan synthase activity
SAM23877_RS09965	COG0133	tryptophan synthase activity
SAM23877_RS09970	COG0134	indole-3-glycerol-phosphate synthase activity
SAM23877_RS09995	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SAM23877_RS10010	COG0107	imidazoleglycerol-phosphate synthase activity
SAM23877_RS10015	COG0251	oxidation-reduction process
SAM23877_RS10020	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SAM23877_RS10025	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SAM23877_RS10035	COG0131	Imidazoleglycerol-phosphate dehydratase
SAM23877_RS10040	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SAM23877_RS10045	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SAM23877_RS10065	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SAM23877_RS10085	COG1432	Conserved Protein
SAM23877_RS10090	COG0587	DNA-directed DNA polymerase activity
SAM23877_RS10130	COG2153	protein acetylation
SAM23877_RS10150	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SAM23877_RS10160	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SAM23877_RS10165	COG3599	regulation of cell shape
SAM23877_RS10175	COG1799	cell septum assembly
SAM23877_RS10185	COG1496	oxidoreductase activity
SAM23877_RS10190	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SAM23877_RS10195	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SAM23877_RS10200	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SAM23877_RS10210	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SAM23877_RS10215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SAM23877_RS10225	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SAM23877_RS10230	COG0768	penicillin binding
SAM23877_RS10240	COG0275	rRNA processing
SAM23877_RS10250	COG0714	Associated with various cellular activities
SAM23877_RS10270	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SAM23877_RS10280	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SAM23877_RS10290	COG1309	transcriptional regulator
SAM23877_RS10310	COG0352	thiamine-phosphate diphosphorylase activity
SAM23877_RS10330	COG2022	thiamine diphosphate biosynthetic process
SAM23877_RS10330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SAM23877_RS10340	COG2022	thiamine diphosphate biosynthetic process
SAM23877_RS10345	COG2815	serine threonine protein kinase
SAM23877_RS10345	COG0515	serine threonine protein kinase
SAM23877_RS10350	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SAM23877_RS10355	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SAM23877_RS10360	COG2193	ferroxidase activity
SAM23877_RS10370	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SAM23877_RS10385	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SAM23877_RS10390	COG0205	6-phosphofructokinase activity
SAM23877_RS10395	COG2197	response regulator
SAM23877_RS10400	COG4585	Histidine kinase
SAM23877_RS10425	COG1940	carbohydrate kinase activity
SAM23877_RS10435	COG0003	Pfam Anion-transporting ATPase
SAM23877_RS10505	COG2205	protein histidine kinase activity
SAM23877_RS10510	COG0745	RESPONSE REGULATOR receiver
SAM23877_RS10520	COG1929	Belongs to the glycerate kinase type-1 family
SAM23877_RS10525	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SAM23877_RS10530	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SAM23877_RS10535	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SAM23877_RS10540	COG0723	plastoquinol--plastocyanin reductase activity
SAM23877_RS10545	COG2010	Cytochrome c
SAM23877_RS10550	COG1845	cytochrome c oxidase, subunit III
SAM23877_RS10560	COG1376	ErfK ybiS ycfS ynhG family protein
SAM23877_RS10570	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SAM23877_RS10575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SAM23877_RS10585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SAM23877_RS10605	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SAM23877_RS10610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SAM23877_RS10615	COG2197	response regulator
SAM23877_RS10620	COG4585	Histidine kinase
SAM23877_RS10650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SAM23877_RS10670	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SAM23877_RS10680	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SAM23877_RS10690	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SAM23877_RS10695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SAM23877_RS10700	COG0508	dehydrogenase complex catalyzes the overall conversion of
SAM23877_RS10710	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SAM23877_RS10730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SAM23877_RS10740	COG1090	epimerase
SAM23877_RS10755	COG0321	lipoyl(octanoyl) transferase activity
SAM23877_RS10760	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SAM23877_RS10780	COG0174	glutamine synthetase
SAM23877_RS10825	COG0745	RESPONSE REGULATOR receiver
SAM23877_RS10840	COG2197	response regulator
SAM23877_RS10865	COG1309	transcriptional regulator
SAM23877_RS10890	COG0366	Alpha amylase catalytic
SAM23877_RS10895	COG3833	ABC-type maltose transport systems, permease component
SAM23877_RS10900	COG1175	transmembrane transport
SAM23877_RS10910	COG1609	Transcriptional regulator
SAM23877_RS10920	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SAM23877_RS10925	COG2161	toxin-antitoxin pair type II binding
SAM23877_RS10930	COG4115	mRNA cleavage
SAM23877_RS10940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SAM23877_RS10940	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SAM23877_RS10955	COG0174	glutamine synthetase
SAM23877_RS10975	COG2814	Major facilitator Superfamily
SAM23877_RS10985	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SAM23877_RS11005	COG1994	Peptidase M50
SAM23877_RS11065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAM23877_RS11070	COG1120	ATPase activity
SAM23877_RS11100	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SAM23877_RS11105	COG2814	Major facilitator Superfamily
SAM23877_RS11115	COG3540	Alkaline phosphatase
SAM23877_RS11120	COG1028	Short-chain dehydrogenase reductase Sdr
SAM23877_RS11165	COG3022	response to hydroperoxide
SAM23877_RS11170	COG0800	Aldolase
SAM23877_RS11185	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SAM23877_RS11195	COG2030	dehydratase
SAM23877_RS11200	COG4585	Histidine kinase
SAM23877_RS11205	COG2197	response regulator
SAM23877_RS11215	COG0477	Major facilitator Superfamily
SAM23877_RS11225	COG2247	cell wall binding repeat
SAM23877_RS11225	COG0860	N-Acetylmuramoyl-L-alanine amidase
SAM23877_RS11255	COG1309	transcriptional regulator
SAM23877_RS11260	COG1657	PFAM Prenyltransferase squalene oxidase
SAM23877_RS11275	COG3845	ABC transporter
SAM23877_RS11300	COG1335	isochorismatase
SAM23877_RS11365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SAM23877_RS11385	COG2259	Doxx family
SAM23877_RS11430	COG0586	Pfam SNARE associated Golgi protein
SAM23877_RS11440	COG1358	cellular component organization or biogenesis
SAM23877_RS11485	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SAM23877_RS11490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SAM23877_RS11500	COG0477	Major facilitator Superfamily
SAM23877_RS11505	COG1309	transcriptional regulator
SAM23877_RS11520	COG0667	Aldo Keto reductase
SAM23877_RS11525	COG0789	Transcriptional regulator
SAM23877_RS11570	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SAM23877_RS11575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SAM23877_RS11580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SAM23877_RS11620	COG1764	response to oxidative stress
SAM23877_RS11625	COG2130	NADP-dependent
SAM23877_RS11660	COG1129	ABC transporter
SAM23877_RS11665	COG4214	carbohydrate transport
SAM23877_RS11675	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SAM23877_RS11680	COG3507	Belongs to the glycosyl hydrolase 43 family
SAM23877_RS11685	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SAM23877_RS11710	COG0395	ABC-type sugar transport system, permease component
SAM23877_RS11715	COG1175	transmembrane transport
SAM23877_RS11745	COG3386	PFAM SMP-30 Gluconolaconase
SAM23877_RS11750	COG1414	Transcriptional regulator
SAM23877_RS11765	COG2186	Transcriptional regulator
SAM23877_RS11775	COG0318	PFAM AMP-dependent synthetase and ligase
SAM23877_RS11780	COG0825	malonyl-CoA metabolic process
SAM23877_RS11780	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SAM23877_RS11810	COG2815	serine threonine protein kinase
SAM23877_RS11810	COG0515	serine threonine protein kinase
SAM23877_RS11815	COG1077	Cell shape determining protein MreB Mrl
SAM23877_RS11850	COG1070	Carbohydrate kinase
SAM23877_RS11875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SAM23877_RS11880	COG0358	DNA primase activity
SAM23877_RS11890	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SAM23877_RS11900	COG2949	membrane
SAM23877_RS11905	COG0243	molybdopterin cofactor binding
SAM23877_RS11935	COG1733	regulation of RNA biosynthetic process
SAM23877_RS11960	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SAM23877_RS11960	COG2146	nitrite reductase [NAD(P)H] activity
SAM23877_RS11985	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SAM23877_RS11990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SAM23877_RS11990	COG0574	Belongs to the PEP-utilizing enzyme family
SAM23877_RS12010	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SAM23877_RS12030	COG0423	glycine-tRNA ligase activity
SAM23877_RS12035	COG3443	Belongs to the bacterial solute-binding protein 9 family
SAM23877_RS12035	COG0803	Belongs to the bacterial solute-binding protein 9 family
SAM23877_RS12040	COG1121	(ABC) transporter
SAM23877_RS12045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SAM23877_RS12055	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SAM23877_RS12060	COG1381	Involved in DNA repair and RecF pathway recombination
SAM23877_RS12090	COG4585	Histidine kinase
SAM23877_RS12095	COG2409	Drug exporters of the RND superfamily
SAM23877_RS12140	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SAM23877_RS12165	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SAM23877_RS12175	COG2315	Protein conserved in bacteria
SAM23877_RS12185	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SAM23877_RS12190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SAM23877_RS12200	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SAM23877_RS12205	COG1234	tRNA 3'-trailer cleavage
SAM23877_RS12210	COG0537	adenosine 5'-monophosphoramidase activity
SAM23877_RS12215	COG4946	Tricorn protease homolog
SAM23877_RS12215	COG0793	Belongs to the peptidase S41A family
SAM23877_RS12240	COG0484	heat shock protein binding
SAM23877_RS12245	COG1420	regulation of RNA biosynthetic process
SAM23877_RS12275	COG0481	GTPase activity
SAM23877_RS12280	COG0268	Binds directly to 16S ribosomal RNA
SAM23877_RS12295	COG2353	YceI-like domain
SAM23877_RS12300	COG2162	N-hydroxyarylamine O-acetyltransferase activity
SAM23877_RS12305	COG1234	tRNA 3'-trailer cleavage
SAM23877_RS12310	COG1555	photosystem II stabilization
SAM23877_RS12315	COG1307	EDD domain protein, DegV family
SAM23877_RS12325	COG0495	leucyl-tRNA aminoacylation
SAM23877_RS12335	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SAM23877_RS12355	COG0588	phosphoglycerate mutase activity
SAM23877_RS12360	COG0799	negative regulation of ribosome biogenesis
SAM23877_RS12370	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SAM23877_RS12375	COG0501	Belongs to the peptidase M48B family
SAM23877_RS12390	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SAM23877_RS12400	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SAM23877_RS12415	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SAM23877_RS12420	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SAM23877_RS12430	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SAM23877_RS12435	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SAM23877_RS12440	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SAM23877_RS12445	COG0371	Dehydrogenase
SAM23877_RS12450	COG1530	ribonuclease E activity
SAM23877_RS12475	COG0772	Belongs to the SEDS family
SAM23877_RS12480	COG0768	penicillin binding
SAM23877_RS12495	COG1077	Cell shape determining protein MreB Mrl
SAM23877_RS12500	COG0105	UTP biosynthetic process
SAM23877_RS12510	COG0285	dihydrofolate synthase activity
SAM23877_RS12515	COG0525	valine-tRNA ligase activity
SAM23877_RS12525	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SAM23877_RS12530	COG0740	serine-type endopeptidase activity
SAM23877_RS12535	COG0740	serine-type endopeptidase activity
SAM23877_RS12540	COG0544	peptidyl-prolyl cis-trans isomerase activity
SAM23877_RS12560	COG3594	Acyltransferase
SAM23877_RS12575	COG4552	Acetyltransferase involved in intracellular survival and related
SAM23877_RS12590	COG1113	amino acid transport
SAM23877_RS12595	COG1268	BioY protein
SAM23877_RS12600	COG1113	amino acid transport
SAM23877_RS12605	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SAM23877_RS12620	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SAM23877_RS12675	COG0697	spore germination
SAM23877_RS12680	COG1846	Transcriptional regulator
SAM23877_RS12700	COG3291	Pkd domain containing protein
SAM23877_RS12700	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SAM23877_RS12710	COG1136	(ABC) transporter
SAM23877_RS12730	COG0668	transmembrane transport
SAM23877_RS12740	COG1486	melibiose metabolic process
SAM23877_RS12755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SAM23877_RS12785	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SAM23877_RS12790	COG2346	COG2346, Truncated hemoglobins
SAM23877_RS12820	COG0629	single-stranded DNA binding
SAM23877_RS12840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SAM23877_RS12855	COG2304	oxidoreductase activity
SAM23877_RS12885	COG0297	glycogen (starch) synthase activity
SAM23877_RS12890	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SAM23877_RS12955	COG1022	Amp-dependent synthetase and ligase
SAM23877_RS12995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SAM23877_RS13020	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SAM23877_RS13030	COG1595	DNA-templated transcription, initiation
SAM23877_RS13045	COG1129	ABC transporter
SAM23877_RS13050	COG1879	ABC-type sugar transport system periplasmic component
SAM23877_RS13055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SAM23877_RS13060	COG1869	D-ribose catabolic process
SAM23877_RS13075	COG0673	inositol 2-dehydrogenase activity
SAM23877_RS13080	COG1609	Transcriptional regulator
SAM23877_RS13135	COG1472	Belongs to the glycosyl hydrolase 3 family
SAM23877_RS13180	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SAM23877_RS13180	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SAM23877_RS13185	COG2356	endonuclease I
SAM23877_RS13190	COG0028	Belongs to the TPP enzyme family
SAM23877_RS13200	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SAM23877_RS13220	COG1946	Acyl-CoA thioesterase
SAM23877_RS13230	COG1309	transcriptional regulator
SAM23877_RS13235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SAM23877_RS13250	COG1960	acyl-CoA dehydrogenase activity
SAM23877_RS13270	COG3486	L-lysine 6-monooxygenase (NADPH) activity
SAM23877_RS13300	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SAM23877_RS13305	COG0589	response to stress
SAM23877_RS13315	COG4977	sequence-specific DNA binding
SAM23877_RS13320	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
SAM23877_RS13355	COG3469	chitinase activity
SAM23877_RS13365	COG0745	RESPONSE REGULATOR receiver
SAM23877_RS13375	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SAM23877_RS13390	COG0406	alpha-ribazole phosphatase activity
SAM23877_RS13415	COG1846	Transcriptional regulator
SAM23877_RS13435	COG0028	Belongs to the TPP enzyme family
SAM23877_RS13445	COG1028	Short-chain dehydrogenase reductase Sdr
SAM23877_RS13455	COG2267	carboxylic ester hydrolase activity
SAM23877_RS13460	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
SAM23877_RS13470	COG1012	belongs to the aldehyde dehydrogenase family
SAM23877_RS13475	COG0477	Major facilitator Superfamily
SAM23877_RS13495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAM23877_RS13550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SAM23877_RS13555	COG0765	amino acid transport
SAM23877_RS13560	COG0765	amino acid transport
SAM23877_RS13565	COG1126	abc transporter atp-binding protein
SAM23877_RS13580	COG3397	chitin binding
SAM23877_RS13655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SAM23877_RS13660	COG2188	Transcriptional regulator
SAM23877_RS13680	COG0673	inositol 2-dehydrogenase activity
SAM23877_RS13685	COG4702	Belongs to the UPF0303 family
SAM23877_RS13700	COG0706	membrane insertase activity
SAM23877_RS13790	COG2814	Major facilitator Superfamily
SAM23877_RS13795	COG2733	membrane
SAM23877_RS13825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SAM23877_RS13865	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SAM23877_RS13875	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SAM23877_RS13880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SAM23877_RS13885	COG1263	PTS System
SAM23877_RS13890	COG1263	PTS System
SAM23877_RS13895	COG1234	tRNA 3'-trailer cleavage
SAM23877_RS13920	COG1113	amino acid transport
SAM23877_RS13930	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SAM23877_RS13940	COG1335	isochorismatase
SAM23877_RS13960	COG1714	RDD family
SAM23877_RS13980	COG0277	FAD linked oxidase domain protein
SAM23877_RS13990	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SAM23877_RS14000	COG1174	glycine betaine transport
SAM23877_RS14010	COG1174	glycine betaine transport
SAM23877_RS14020	COG3480	Lon protease (S16) C-terminal proteolytic domain
SAM23877_RS14045	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SAM23877_RS14060	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SAM23877_RS14065	COG0395	ABC-type sugar transport system, permease component
SAM23877_RS14070	COG1175	transmembrane transport
SAM23877_RS14085	COG1678	Uncharacterized ACR, COG1678
SAM23877_RS14090	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SAM23877_RS14095	COG0776	regulation of translation
SAM23877_RS14105	COG3973	AAA domain
SAM23877_RS14135	COG2223	nitrite transmembrane transporter activity
SAM23877_RS14165	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SAM23877_RS14170	COG0793	Belongs to the peptidase S41A family
SAM23877_RS14180	COG2884	Cell division ATP-binding protein ftsE
SAM23877_RS14195	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SAM23877_RS14200	COG0515	serine threonine protein kinase
SAM23877_RS14205	COG0515	serine threonine protein kinase
SAM23877_RS14220	COG1175	transmembrane transport
SAM23877_RS14225	COG0395	ABC-type sugar transport system, permease component
SAM23877_RS14230	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SAM23877_RS14235	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SAM23877_RS14240	COG1216	Glycosyl transferase, family 2
SAM23877_RS14255	COG1764	response to oxidative stress
SAM23877_RS14260	COG1846	Transcriptional regulator
SAM23877_RS14280	COG1134	teichoic acid transport
SAM23877_RS14285	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SAM23877_RS14290	COG1216	Glycosyl transferase, family 2
SAM23877_RS14320	COG2902	Dehydrogenase
SAM23877_RS14340	COG0653	protein targeting
SAM23877_RS14350	COG3214	Protein conserved in bacteria
SAM23877_RS14355	COG2197	response regulator
SAM23877_RS14360	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SAM23877_RS14370	COG0823	Involved in the tonB-independent uptake of proteins
SAM23877_RS14375	COG5002	protein histidine kinase activity
SAM23877_RS14380	COG0745	RESPONSE REGULATOR receiver
SAM23877_RS14385	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SAM23877_RS14405	COG0714	Associated with various cellular activities
SAM23877_RS14445	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SAM23877_RS14455	COG1482	cell wall glycoprotein biosynthetic process
SAM23877_RS14465	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SAM23877_RS14470	COG1620	l-lactate permease
SAM23877_RS14510	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SAM23877_RS14515	COG0778	Nitroreductase
SAM23877_RS14515	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
SAM23877_RS14540	COG1316	TRANSCRIPTIONal
SAM23877_RS14545	COG1316	TRANSCRIPTIONal
SAM23877_RS14550	COG1316	TRANSCRIPTIONal
SAM23877_RS14555	COG1316	TRANSCRIPTIONal
SAM23877_RS14560	COG1316	TRANSCRIPTIONal
SAM23877_RS14570	COG1316	TRANSCRIPTIONal
SAM23877_RS14575	COG1316	TRANSCRIPTIONal
SAM23877_RS14615	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SAM23877_RS14640	COG0789	Transcriptional regulator
SAM23877_RS14645	COG1902	pentaerythritol trinitrate reductase activity
SAM23877_RS14670	COG2205	protein histidine kinase activity
SAM23877_RS14675	COG0745	RESPONSE REGULATOR receiver
SAM23877_RS14680	COG3104	oligopeptide transport
SAM23877_RS14690	COG1366	Belongs to the anti-sigma-factor antagonist family
SAM23877_RS14695	COG1191	sigma factor activity
SAM23877_RS14705	COG1228	amidohydrolase
SAM23877_RS14720	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SAM23877_RS14750	COG2755	lipolytic protein G-D-S-L family
SAM23877_RS14755	COG0183	Belongs to the thiolase family
SAM23877_RS14790	COG1136	(ABC) transporter
SAM23877_RS14795	COG1136	(ABC) transporter
SAM23877_RS14795	COG0577	efflux transmembrane transporter activity
SAM23877_RS14800	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SAM23877_RS14805	COG1252	NADH dehydrogenase
SAM23877_RS14825	COG0148	phosphopyruvate hydratase activity
SAM23877_RS14885	COG0577	efflux transmembrane transporter activity
SAM23877_RS14890	COG1136	(ABC) transporter
SAM23877_RS14895	COG2814	Major facilitator Superfamily
SAM23877_RS14905	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SAM23877_RS14935	COG4585	Histidine kinase
SAM23877_RS14940	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SAM23877_RS14945	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SAM23877_RS14950	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SAM23877_RS14955	COG0193	aminoacyl-tRNA hydrolase activity
SAM23877_RS14965	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SAM23877_RS14975	COG1309	transcriptional regulator
SAM23877_RS14985	COG4106	trans-aconitate 2-methyltransferase activity
SAM23877_RS14995	COG2197	response regulator
SAM23877_RS15005	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SAM23877_RS15045	COG0488	(ABC) transporter
SAM23877_RS15050	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SAM23877_RS15055	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SAM23877_RS15065	COG0084	hydrolase, TatD family'
SAM23877_RS15100	COG0310	cobalt ion transport
SAM23877_RS15110	COG1122	ATPase activity
SAM23877_RS15115	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SAM23877_RS15130	COG0442	prolyl-tRNA aminoacylation
SAM23877_RS15140	COG1595	DNA-templated transcription, initiation
SAM23877_RS15145	COG2409	Drug exporters of the RND superfamily
SAM23877_RS15155	COG0793	Belongs to the peptidase S41A family
SAM23877_RS15155	COG4946	Tricorn protease homolog
SAM23877_RS15170	COG2267	carboxylic ester hydrolase activity
SAM23877_RS15175	COG2072	flavoprotein involved in K transport
SAM23877_RS15185	COG0708	Exodeoxyribonuclease III
SAM23877_RS15205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SAM23877_RS15210	COG0521	Mo-molybdopterin cofactor biosynthetic process
SAM23877_RS15210	COG0315	cyclic pyranopterin monophosphate synthase activity
SAM23877_RS15215	COG0315	cyclic pyranopterin monophosphate synthase activity
SAM23877_RS15225	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SAM23877_RS15230	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SAM23877_RS15240	COG3263	regulation of cellular component size
SAM23877_RS15250	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SAM23877_RS15260	COG1970	mechanosensitive ion channel activity
SAM23877_RS15275	COG3191	aminopeptidase activity
SAM23877_RS15290	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
SAM23877_RS15290	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SAM23877_RS15290	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SAM23877_RS15300	COG1349	DNA-binding transcription factor activity
SAM23877_RS15305	COG0477	Major facilitator Superfamily
SAM23877_RS15320	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SAM23877_RS15325	COG3384	dioxygenase
SAM23877_RS15330	COG1846	Transcriptional regulator
SAM23877_RS15350	COG1414	Transcriptional regulator
SAM23877_RS15445	COG1309	transcriptional regulator
SAM23877_RS15450	COG4257	antibiotic catabolic process
SAM23877_RS15455	COG0110	maltose O-acetyltransferase activity
SAM23877_RS15475	COG0386	Belongs to the glutathione peroxidase family
SAM23877_RS15500	COG1686	Belongs to the peptidase S11 family
SAM23877_RS15555	COG2365	Tyrosine phosphatase family
SAM23877_RS15570	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SAM23877_RS15590	COG3903	Transcriptional regulator
SAM23877_RS15590	COG3629	intracellular signal transduction
SAM23877_RS15600	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SAM23877_RS15600	COG0515	serine threonine protein kinase
SAM23877_RS15610	COG1309	transcriptional regulator
SAM23877_RS15615	COG1522	sequence-specific DNA binding
SAM23877_RS15620	COG1280	lysine exporter protein (LysE YggA)
SAM23877_RS15630	COG0259	pyridoxamine-phosphate oxidase activity
SAM23877_RS15640	COG2072	flavoprotein involved in K transport
SAM23877_RS15645	COG2271	Major facilitator Superfamily
SAM23877_RS15665	COG1366	Belongs to the anti-sigma-factor antagonist family
SAM23877_RS15670	COG1595	DNA-templated transcription, initiation
SAM23877_RS15715	COG2945	thiolester hydrolase activity
SAM23877_RS15715	COG0596	Alpha beta hydrolase
SAM23877_RS15725	COG4821	SIS domain
SAM23877_RS15740	COG0259	pyridoxamine-phosphate oxidase activity
SAM23877_RS15755	COG0318	PFAM AMP-dependent synthetase and ligase
SAM23877_RS15770	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SAM23877_RS15800	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SAM23877_RS15805	COG2226	methyltransferase
SAM23877_RS15810	COG2188	Transcriptional regulator
SAM23877_RS15825	COG0277	FAD linked oxidase domain protein
SAM23877_RS15825	COG0247	lactate metabolic process
SAM23877_RS15830	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SAM23877_RS15860	COG0667	Aldo Keto reductase
SAM23877_RS15885	COG2252	PERMEase
SAM23877_RS15895	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SAM23877_RS15910	COG2814	Major facilitator Superfamily
SAM23877_RS15920	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SAM23877_RS15925	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SAM23877_RS15930	COG1278	Cold shock
SAM23877_RS16000	COG1061	Type III restriction enzyme res subunit
SAM23877_RS16010	COG3973	AAA domain
SAM23877_RS16015	COG3142	Participates in the control of copper homeostasis
SAM23877_RS16045	COG1737	Transcriptional regulator
SAM23877_RS16050	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SAM23877_RS16055	COG1263	PTS System
SAM23877_RS16055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SAM23877_RS16075	COG0459	protein refolding
SAM23877_RS16080	COG1278	Cold shock
SAM23877_RS16095	COG0463	Glycosyl transferase, family 2
SAM23877_RS16130	COG1940	carbohydrate kinase activity
SAM23877_RS16165	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SAM23877_RS16175	COG2197	response regulator
SAM23877_RS16195	COG0494	nUDIX hydrolase
SAM23877_RS16230	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SAM23877_RS16230	COG1672	PFAM Archaeal ATPase
SAM23877_RS16245	COG0464	growth
SAM23877_RS16330	COG3842	ATPase activity
SAM23877_RS16350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SAM23877_RS16355	COG0215	cysteine-tRNA ligase activity
SAM23877_RS16360	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SAM23877_RS16365	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SAM23877_RS16370	COG1329	Transcriptional regulator
SAM23877_RS16385	COG5002	protein histidine kinase activity
SAM23877_RS16445	COG2188	Transcriptional regulator
SAM23877_RS16455	COG0222	ribosome binding
SAM23877_RS16460	COG0588	phosphoglycerate mutase activity
SAM23877_RS16485	COG0438	transferase activity, transferring glycosyl groups
SAM23877_RS16520	COG1733	regulation of RNA biosynthetic process
SAM23877_RS16535	COG0546	phosphoglycolate phosphatase activity
SAM23877_RS16540	COG2188	Transcriptional regulator
SAM23877_RS16560	COG4552	Acetyltransferase involved in intracellular survival and related
SAM23877_RS16575	COG1490	D-aminoacyl-tRNA deacylase activity
SAM23877_RS16585	COG0735	belongs to the Fur family
SAM23877_RS16590	COG3485	protocatechuate 3,4-dioxygenase
SAM23877_RS16610	COG2897	thiosulfate sulfurtransferase activity
SAM23877_RS16635	COG0745	RESPONSE REGULATOR receiver
SAM23877_RS16640	COG1609	Transcriptional regulator
SAM23877_RS16645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SAM23877_RS16650	COG0745	RESPONSE REGULATOR receiver
SAM23877_RS16680	COG0737	Belongs to the 5'-nucleotidase family
SAM23877_RS16685	COG0456	acetyltransferase
SAM23877_RS16715	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SAM23877_RS16725	COG0494	nUDIX hydrolase
SAM23877_RS16725	COG0406	alpha-ribazole phosphatase activity
SAM23877_RS16745	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SAM23877_RS16750	COG0306	phosphate transporter
SAM23877_RS16760	COG1937	Protein conserved in bacteria
SAM23877_RS16770	COG0277	FAD linked oxidase domain protein
SAM23877_RS16775	COG0671	phosphoesterase, PA-phosphatase related
SAM23877_RS16780	COG0739	heme binding
SAM23877_RS16780	COG1196	nuclear chromosome segregation
SAM23877_RS16780	COG0741	lytic transglycosylase activity
SAM23877_RS16820	COG4585	Histidine kinase
SAM23877_RS16825	COG2197	response regulator
SAM23877_RS16855	COG1252	NADH dehydrogenase
SAM23877_RS16880	COG0579	oxidoreductase
SAM23877_RS16885	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SAM23877_RS16895	COG0667	Aldo Keto reductase
SAM23877_RS16915	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SAM23877_RS16915	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SAM23877_RS16920	COG2208	phosphoserine phosphatase activity
SAM23877_RS16920	COG2770	Histidine kinase
SAM23877_RS16925	COG0596	Alpha beta hydrolase
SAM23877_RS16975	COG1643	Atp-dependent helicase
SAM23877_RS17010	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SAM23877_RS17045	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SAM23877_RS17050	COG0047	phosphoribosylformylglycinamidine synthase activity
SAM23877_RS17055	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SAM23877_RS17085	COG3851	Histidine kinase
SAM23877_RS17090	COG2197	response regulator
SAM23877_RS17100	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SAM23877_RS17115	COG0151	Belongs to the GarS family
SAM23877_RS17185	COG2188	Transcriptional regulator
SAM23877_RS17205	COG0270	DNA (cytosine-5-)-methyltransferase activity
SAM23877_RS17265	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SAM23877_RS17295	COG1191	sigma factor activity
SAM23877_RS17300	COG1191	sigma factor activity
SAM23877_RS17315	COG0477	Major facilitator Superfamily
SAM23877_RS17320	COG2353	YceI-like domain
SAM23877_RS17350	COG0477	Major facilitator Superfamily
SAM23877_RS17355	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SAM23877_RS17365	COG2205	protein histidine kinase activity
SAM23877_RS17370	COG0745	RESPONSE REGULATOR receiver
SAM23877_RS17390	COG1733	regulation of RNA biosynthetic process
SAM23877_RS17395	COG0768	penicillin binding
SAM23877_RS17415	COG0784	Response regulator, receiver
SAM23877_RS17420	COG1309	transcriptional regulator
SAM23877_RS17425	COG2814	Major facilitator Superfamily
SAM23877_RS17430	COG0318	PFAM AMP-dependent synthetase and ligase
SAM23877_RS17435	COG1595	DNA-templated transcription, initiation
SAM23877_RS17480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SAM23877_RS17495	COG0653	protein targeting
SAM23877_RS17515	COG0006	proline dipeptidase activity
SAM23877_RS17535	COG1999	signal sequence binding
SAM23877_RS17550	COG2837	iron assimilation
SAM23877_RS17555	COG0077	Prephenate dehydratase
SAM23877_RS17560	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SAM23877_RS17565	COG0561	phosphatase activity
SAM23877_RS17585	COG1131	(ABC) transporter
SAM23877_RS17600	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
SAM23877_RS17610	COG0561	phosphatase activity
SAM23877_RS17615	COG0739	heme binding
SAM23877_RS17625	COG4988	ABC transporter
SAM23877_RS17630	COG1294	oxidase, subunit
SAM23877_RS17635	COG1271	oxidase subunit
SAM23877_RS17645	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SAM23877_RS17650	COG1609	Transcriptional regulator
SAM23877_RS17655	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SAM23877_RS17670	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SAM23877_RS17695	COG0662	Cupin 2, conserved barrel domain protein
SAM23877_RS17700	COG1950	PFAM Membrane protein of
SAM23877_RS17705	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SAM23877_RS17710	COG0626	cystathionine gamma-synthase activity
SAM23877_RS17735	COG2814	Major facilitator Superfamily
SAM23877_RS17755	COG0305	Participates in initiation and elongation during chromosome replication
SAM23877_RS17765	COG0359	binds to the 23S rRNA
SAM23877_RS17770	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SAM23877_RS17775	COG0629	single-stranded DNA binding
SAM23877_RS17780	COG0360	Binds together with S18 to 16S ribosomal RNA
SAM23877_RS17805	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SAM23877_RS17815	COG1260	myo-inositol-1-phosphate synthase
SAM23877_RS17830	COG0617	tRNA 3'-terminal CCA addition
SAM23877_RS17845	COG0515	serine threonine protein kinase
SAM23877_RS17845	COG2815	serine threonine protein kinase
SAM23877_RS17850	COG1595	DNA-templated transcription, initiation
SAM23877_RS17860	COG0492	ferredoxin-NADP+ reductase activity
SAM23877_RS17865	COG3118	belongs to the thioredoxin family
SAM23877_RS17880	COG1192	Involved in chromosome partitioning
SAM23877_RS17885	COG0357	Ribosomal RNA small subunit methyltransferase G
SAM23877_RS17895	COG0706	membrane insertase activity
SAM23877_RS17900	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SAM23877_RS17910	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SAM23877_RS17915	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SAM23877_RS17920	COG0592	DNA-directed DNA polymerase activity
SAM23877_RS17925	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SAM23877_RS17930	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SAM23877_RS17935	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
SAM23877_RS17940	COG0187	DNA topoisomerase II activity
SAM23877_RS17945	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SAM23877_RS17965	COG4249	Peptidase C14 caspase catalytic subunit p20
SAM23877_RS17965	COG2319	Wd-40 repeat
SAM23877_RS17995	COG0515	serine threonine protein kinase
SAM23877_RS18010	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SAM23877_RS18025	COG0705	Rhomboid family
SAM23877_RS18045	COG3764	Sortase (surface protein transpeptidase)
SAM23877_RS18050	COG3764	Sortase (surface protein transpeptidase)
SAM23877_RS18055	COG0515	serine threonine protein kinase
SAM23877_RS18060	COG0768	penicillin binding
SAM23877_RS18075	COG1716	ATPase activity
SAM23877_RS18080	COG1716	ATPase activity
SAM23877_RS18130	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAM23877_RS18135	COG1309	transcriptional regulator
SAM23877_RS18140	COG1522	sequence-specific DNA binding
SAM23877_RS18185	COG1028	Short-chain dehydrogenase reductase Sdr
SAM23877_RS18185	COG3321	synthase
SAM23877_RS18185	COG0604	alcohol dehydrogenase
SAM23877_RS18205	COG0515	serine threonine protein kinase
SAM23877_RS18210	COG0515	serine threonine protein kinase
SAM23877_RS18230	COG0022	dehydrogenase e1 component
SAM23877_RS18235	COG0508	dehydrogenase complex catalyzes the overall conversion of
SAM23877_RS18255	COG2186	Transcriptional regulator
SAM23877_RS18290	COG1362	aminopeptidase activity
SAM23877_RS18295	COG1960	acyl-CoA dehydrogenase activity
SAM23877_RS18305	COG1741	Belongs to the pirin family
SAM23877_RS18320	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SAM23877_RS18350	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SAM23877_RS18400	COG1653	transport
SAM23877_RS18425	COG0366	Alpha amylase catalytic
SAM23877_RS18430	COG1957	nucleoside hydrolase
SAM23877_RS18450	COG0583	DNA-binding transcription factor activity
SAM23877_RS18475	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SAM23877_RS18505	COG1278	Cold shock
SAM23877_RS18535	COG0745	RESPONSE REGULATOR receiver
SAM23877_RS18540	COG5002	protein histidine kinase activity
SAM23877_RS18545	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SAM23877_RS18580	COG0513	Belongs to the DEAD box helicase family
SAM23877_RS18585	COG1278	Cold shock
SAM23877_RS18620	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SAM23877_RS18625	COG0667	Aldo Keto reductase
SAM23877_RS18635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SAM23877_RS18665	COG2050	protein possibly involved in aromatic compounds catabolism
SAM23877_RS18670	COG0667	Aldo Keto reductase
SAM23877_RS18685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SAM23877_RS18695	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
SAM23877_RS18705	COG0717	Belongs to the dCTP deaminase family
SAM23877_RS18710	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SAM23877_RS18725	COG2181	nitrate reductase activity
SAM23877_RS18725	COG0247	lactate metabolic process
SAM23877_RS18730	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SAM23877_RS18735	COG0443	Heat shock 70 kDa protein
SAM23877_RS18740	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SAM23877_RS18745	COG0484	heat shock protein binding
SAM23877_RS18750	COG0789	Transcriptional regulator
SAM23877_RS18755	COG4213	ABC transporter substrate-binding protein
SAM23877_RS18765	COG1136	(ABC) transporter
SAM23877_RS18805	COG0542	response to heat
SAM23877_RS18830	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SAM23877_RS18845	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SAM23877_RS18850	COG0191	fructose-bisphosphate aldolase activity
SAM23877_RS18855	COG0477	Major facilitator Superfamily
SAM23877_RS18870	COG3844	kynureninase activity
SAM23877_RS18895	COG4585	Histidine kinase
SAM23877_RS18900	COG2197	response regulator
SAM23877_RS18905	COG4585	Histidine kinase
SAM23877_RS18910	COG2197	response regulator
SAM23877_RS18915	COG2124	cytochrome p450
SAM23877_RS18920	COG3559	Exporter of polyketide antibiotics
SAM23877_RS18925	COG1131	(ABC) transporter
SAM23877_RS18940	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SAM23877_RS18955	COG1595	DNA-templated transcription, initiation
SAM23877_RS18970	COG1802	Transcriptional regulator
SAM23877_RS18980	COG0693	protein deglycase activity
SAM23877_RS19000	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SAM23877_RS19005	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SAM23877_RS19025	COG1595	DNA-templated transcription, initiation
SAM23877_RS19050	COG1585	Membrane protein implicated in regulation of membrane protease activity
SAM23877_RS19055	COG2268	Band 7 protein
SAM23877_RS19070	COG3655	Transcriptional regulator
SAM23877_RS19080	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SAM23877_RS19170	COG0494	nUDIX hydrolase
SAM23877_RS19185	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
SAM23877_RS19195	COG0406	alpha-ribazole phosphatase activity
SAM23877_RS19200	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SAM23877_RS19340	COG1408	metallophosphoesterase
SAM23877_RS19345	COG1610	YqeY-like protein
SAM23877_RS19350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SAM23877_RS19360	COG0003	Pfam Anion-transporting ATPase
SAM23877_RS19375	COG0596	Alpha beta hydrolase
SAM23877_RS19385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SAM23877_RS19410	COG2267	carboxylic ester hydrolase activity
SAM23877_RS19420	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SAM23877_RS19425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SAM23877_RS19485	COG1111	helicase
SAM23877_RS19485	COG1205	dead DEAH box helicase
SAM23877_RS19490	COG1366	Belongs to the anti-sigma-factor antagonist family
SAM23877_RS19500	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SAM23877_RS19520	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SAM23877_RS19520	COG1754	DNA topoisomerase type I activity
SAM23877_RS19525	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SAM23877_RS19555	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SAM23877_RS19555	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SAM23877_RS19565	COG1280	lysine exporter protein (LysE YggA)
SAM23877_RS19590	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SAM23877_RS19595	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SAM23877_RS19600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SAM23877_RS19605	COG0254	rRNA binding
SAM23877_RS19615	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SAM23877_RS19635	COG1012	belongs to the aldehyde dehydrogenase family
SAM23877_RS19640	COG2318	DinB family
SAM23877_RS19660	COG0076	glutamate decarboxylase activity
SAM23877_RS19665	COG0789	Transcriptional regulator
SAM23877_RS19670	COG0393	Putative heavy-metal-binding
SAM23877_RS19685	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SAM23877_RS19690	COG2027	D-alanyl-D-alanine carboxypeptidase
SAM23877_RS19700	COG0037	tRNA processing
SAM23877_RS19715	COG0302	gtp cyclohydrolase
SAM23877_RS19725	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SAM23877_RS19730	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SAM23877_RS19770	COG0649	NAD binding
SAM23877_RS19785	COG2197	response regulator
SAM23877_RS19790	COG0640	Transcriptional regulator
SAM23877_RS19810	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SAM23877_RS19815	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SAM23877_RS19825	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SAM23877_RS19830	COG3547	Transposase (IS116 IS110 IS902 family)
SAM23877_RS19850	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SAM23877_RS19880	COG0739	heme binding
SAM23877_RS19900	COG2205	protein histidine kinase activity
SAM23877_RS19905	COG0745	RESPONSE REGULATOR receiver
SAM23877_RS19915	COG1595	DNA-templated transcription, initiation
SAM23877_RS19920	COG1194	a g-specific adenine glycosylase
SAM23877_RS19925	COG4585	Histidine kinase
SAM23877_RS19935	COG0671	phosphoesterase, PA-phosphatase related
SAM23877_RS19945	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
SAM23877_RS19965	COG0248	Ppx GppA phosphatase
SAM23877_RS19970	COG1082	Xylose isomerase domain protein TIM barrel
SAM23877_RS19975	COG1309	transcriptional regulator
SAM23877_RS19980	COG0129	dihydroxy-acid dehydratase activity
SAM23877_RS19985	COG0515	serine threonine protein kinase
SAM23877_RS19985	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SAM23877_RS20005	COG0842	Transport permease protein
SAM23877_RS20005	COG1129	ABC transporter
SAM23877_RS20015	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SAM23877_RS20020	COG0180	Tryptophanyl-tRNA synthetase
SAM23877_RS20040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SAM23877_RS20050	COG2223	nitrite transmembrane transporter activity
SAM23877_RS20055	COG0123	including yeast histone deacetylase and acetoin utilization protein
SAM23877_RS20100	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SAM23877_RS20105	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SAM23877_RS20110	COG0181	hydroxymethylbilane synthase activity
SAM23877_RS20115	COG1648	precorrin-2 dehydrogenase activity
SAM23877_RS20115	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SAM23877_RS20130	COG0113	porphobilinogen synthase activity
SAM23877_RS20145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SAM23877_RS20160	COG0018	arginyl-trna synthetase
SAM23877_RS20165	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
SAM23877_RS20185	COG1690	Belongs to the RtcB family
SAM23877_RS20195	COG1742	UPF0060 membrane protein
SAM23877_RS20205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAM23877_RS20210	COG0431	NADPH-dependent FMN reductase
SAM23877_RS20215	COG0745	RESPONSE REGULATOR receiver
SAM23877_RS20220	COG2205	protein histidine kinase activity
SAM23877_RS20250	COG3547	Transposase (IS116 IS110 IS902 family)
SAM23877_RS20270	COG0513	Belongs to the DEAD box helicase family
SAM23877_RS20275	COG1278	Cold shock
SAM23877_RS20325	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SAM23877_RS20330	COG0406	alpha-ribazole phosphatase activity
SAM23877_RS20340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SAM23877_RS20345	COG0785	Cytochrome C biogenesis protein
SAM23877_RS20350	COG1333	cytochrome c biogenesis protein
SAM23877_RS20355	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SAM23877_RS20405	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SAM23877_RS20410	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SAM23877_RS20415	COG0163	prenyltransferase activity
SAM23877_RS20425	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SAM23877_RS20430	COG1573	uracil-dna glycosylase
SAM23877_RS20450	COG1309	transcriptional regulator
SAM23877_RS20465	COG0183	Belongs to the thiolase family
SAM23877_RS20475	COG2226	methyltransferase
SAM23877_RS20490	COG1396	sequence-specific DNA binding
SAM23877_RS20495	COG1278	Cold shock
SAM23877_RS20500	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SAM23877_RS20510	COG1674	ftsk spoiiie
SAM23877_RS20625	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
SAM23877_RS20715	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SAM23877_RS20730	COG2226	methyltransferase
SAM23877_RS20745	COG0242	peptide deformylase activity
SAM23877_RS20760	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAM23877_RS20765	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAM23877_RS20770	COG0649	NAD binding
SAM23877_RS20780	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SAM23877_RS20785	COG1034	ATP synthesis coupled electron transport
SAM23877_RS20790	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SAM23877_RS20795	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAM23877_RS20805	COG0713	ATP synthesis coupled electron transport
SAM23877_RS20810	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SAM23877_RS20820	COG1007	ATP synthesis coupled electron transport
SAM23877_RS20830	COG0514	ATP-dependent DNA helicase (RecQ)
SAM23877_RS20840	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
SAM23877_RS20860	COG2188	Transcriptional regulator
SAM23877_RS20875	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SAM23877_RS20900	COG0726	polysaccharide deacetylase
SAM23877_RS20915	COG0561	phosphatase activity
SAM23877_RS20925	COG0142	geranyltranstransferase activity
SAM23877_RS20935	COG1131	(ABC) transporter
SAM23877_RS20945	COG0655	NAD(P)H dehydrogenase (quinone) activity
SAM23877_RS20975	COG0702	epimerase
SAM23877_RS20980	COG1013	pyruvate-flavodoxin oxidoreductase activity
SAM23877_RS20985	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SAM23877_RS20985	COG0674	pyruvate-flavodoxin oxidoreductase activity
SAM23877_RS21005	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAM23877_RS21010	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAM23877_RS21015	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAM23877_RS21020	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SAM23877_RS21025	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAM23877_RS21035	COG0713	ATP synthesis coupled electron transport
SAM23877_RS21040	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SAM23877_RS21050	COG1007	ATP synthesis coupled electron transport
SAM23877_RS21055	COG0501	Belongs to the peptidase M48B family
SAM23877_RS21060	COG3304	Inner membrane component domain
SAM23877_RS21075	COG2261	transglycosylase associated protein
SAM23877_RS21080	COG1666	GTP binding
SAM23877_RS21090	COG0702	epimerase
SAM23877_RS21095	COG0402	S-adenosylhomocysteine deaminase activity
SAM23877_RS21110	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SAM23877_RS21115	COG2030	dehydratase
SAM23877_RS21130	COG0477	Major facilitator Superfamily
SAM23877_RS21140	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SAM23877_RS21150	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SAM23877_RS21155	COG0436	Aminotransferase
SAM23877_RS21165	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SAM23877_RS21170	COG0250	Participates in transcription elongation, termination and antitermination
SAM23877_RS21175	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SAM23877_RS21180	COG0081	regulation of translation
SAM23877_RS21195	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SAM23877_RS21200	COG0222	ribosome binding
SAM23877_RS21205	COG0085	RNA polymerase activity
SAM23877_RS21210	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SAM23877_RS21220	COG0463	Glycosyl transferase, family 2
SAM23877_RS21225	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SAM23877_RS21230	COG0049	tRNA binding
SAM23877_RS21235	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SAM23877_RS21240	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SAM23877_RS21260	COG0577	efflux transmembrane transporter activity
SAM23877_RS21265	COG1136	(ABC) transporter
SAM23877_RS21275	COG2197	response regulator
SAM23877_RS21310	COG1028	Short-chain dehydrogenase reductase Sdr
SAM23877_RS21320	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SAM23877_RS21325	COG0051	transcription antitermination factor activity, RNA binding
SAM23877_RS21330	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SAM23877_RS21335	COG0088	Forms part of the polypeptide exit tunnel
SAM23877_RS21340	COG0089	rRNA binding
SAM23877_RS21345	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SAM23877_RS21350	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SAM23877_RS21355	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SAM23877_RS21360	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SAM23877_RS21365	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SAM23877_RS21370	COG0255	Belongs to the universal ribosomal protein uL29 family
SAM23877_RS21375	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SAM23877_RS21380	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SAM23877_RS21385	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SAM23877_RS21390	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SAM23877_RS21395	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SAM23877_RS21400	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SAM23877_RS21405	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SAM23877_RS21410	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SAM23877_RS21415	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SAM23877_RS21420	COG1841	ribosomal large subunit assembly
SAM23877_RS21425	COG0200	Binds to the 23S rRNA
SAM23877_RS21430	COG0201	protein transport
SAM23877_RS21435	COG0563	adenylate kinase activity
SAM23877_RS21445	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SAM23877_RS21450	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SAM23877_RS21455	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SAM23877_RS21460	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SAM23877_RS21465	COG0202	RNA polymerase activity
SAM23877_RS21470	COG0203	ribosomal protein L17
SAM23877_RS21475	COG0101	tRNA pseudouridine synthase activity
SAM23877_RS21490	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SAM23877_RS21495	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SAM23877_RS21500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SAM23877_RS21505	COG1072	(Pantothenic acid kinase))
SAM23877_RS21515	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SAM23877_RS21535	COG0736	holo-[acyl-carrier-protein] synthase activity
SAM23877_RS21540	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SAM23877_RS21550	COG0802	atpase or kinase
SAM23877_RS21560	COG1214	PFAM Peptidase M22, glycoprotease
SAM23877_RS21560	COG0456	acetyltransferase
SAM23877_RS21570	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SAM23877_RS21585	COG1316	TRANSCRIPTIONal
SAM23877_RS21595	COG4941	Belongs to the sigma-70 factor family
SAM23877_RS21605	COG0726	polysaccharide deacetylase
SAM23877_RS21610	COG0726	polysaccharide deacetylase
SAM23877_RS21615	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SAM23877_RS21620	COG0459	protein refolding
SAM23877_RS21625	COG1201	RNA secondary structure unwinding
SAM23877_RS21715	COG4221	oxidoreductase activity
SAM23877_RS21725	COG0583	DNA-binding transcription factor activity
SAM23877_RS21735	COG2197	response regulator
SAM23877_RS21740	COG1595	DNA-templated transcription, initiation
SAM23877_RS21750	COG0516	GMP reductase activity
SAM23877_RS21760	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SAM23877_RS21770	COG0515	serine threonine protein kinase
SAM23877_RS21770	COG2815	serine threonine protein kinase
SAM23877_RS21775	COG0515	serine threonine protein kinase
SAM23877_RS21780	COG2815	serine threonine protein kinase
SAM23877_RS21780	COG0515	serine threonine protein kinase
SAM23877_RS21785	COG0515	serine threonine protein kinase
SAM23877_RS21790	COG0515	serine threonine protein kinase
SAM23877_RS21795	COG1012	belongs to the aldehyde dehydrogenase family
SAM23877_RS21815	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SAM23877_RS21815	COG0519	Catalyzes the synthesis of GMP from XMP
SAM23877_RS21860	COG2197	response regulator
SAM23877_RS21865	COG0791	NLP P60 protein
SAM23877_RS21890	COG0739	heme binding
SAM23877_RS21900	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SAM23877_RS21900	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SAM23877_RS21915	COG0714	Associated with various cellular activities
SAM23877_RS21920	COG2425	protein containing a von Willebrand factor type A (vWA) domain
SAM23877_RS21925	COG3552	Protein containing von Willebrand factor type A (VWA) domain
SAM23877_RS21935	COG0045	succinate-CoA ligase (ADP-forming) activity
SAM23877_RS21965	COG0138	bifunctional purine biosynthesis protein purh
SAM23877_RS21975	COG0515	serine threonine protein kinase
SAM23877_RS21990	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SAM23877_RS22005	COG0039	L-malate dehydrogenase activity
SAM23877_RS22025	COG1012	belongs to the aldehyde dehydrogenase family
SAM23877_RS22035	COG0517	IMP dehydrogenase activity
SAM23877_RS22035	COG4175	Glycine betaine
SAM23877_RS22040	COG4176	ABC-type proline glycine betaine transport system permease component
SAM23877_RS22055	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SAM23877_RS22060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SAM23877_RS22070	COG0754	glutathionylspermidine amidase activity
SAM23877_RS22075	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SAM23877_RS22080	COG0180	Tryptophanyl-tRNA synthetase
SAM23877_RS22100	COG0671	phosphoesterase, PA-phosphatase related
SAM23877_RS22115	COG1295	ribonuclease BN
SAM23877_RS22120	COG1686	Belongs to the peptidase S11 family
SAM23877_RS22130	COG1408	metallophosphoesterase
SAM23877_RS22135	COG1309	transcriptional regulator
SAM23877_RS22175	COG1053	succinate dehydrogenase
SAM23877_RS22185	COG2009	succinate dehydrogenase
SAM23877_RS22215	COG1595	DNA-templated transcription, initiation
SAM23877_RS22225	COG1595	DNA-templated transcription, initiation
SAM23877_RS22240	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SAM23877_RS22240	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SAM23877_RS22280	COG1216	Glycosyl transferase, family 2
SAM23877_RS22300	COG1216	Glycosyl transferase, family 2
SAM23877_RS22315	COG2089	acid synthase
SAM23877_RS22330	COG1473	amidohydrolase
SAM23877_RS22330	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SAM23877_RS22335	COG1744	ABC transporter substrate-binding protein PnrA-like
SAM23877_RS22340	COG1744	ABC transporter substrate-binding protein PnrA-like
SAM23877_RS22345	COG3845	ABC transporter
SAM23877_RS22355	COG1079	Belongs to the binding-protein-dependent transport system permease family
SAM23877_RS22370	COG3344	reverse transcriptase
SAM23877_RS22390	COG2814	Major facilitator Superfamily
SAM23877_RS22395	COG0583	DNA-binding transcription factor activity
SAM23877_RS22405	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SAM23877_RS22430	COG2205	protein histidine kinase activity
SAM23877_RS22435	COG0745	RESPONSE REGULATOR receiver
SAM23877_RS22440	COG1595	DNA-templated transcription, initiation
SAM23877_RS22455	COG1012	belongs to the aldehyde dehydrogenase family
SAM23877_RS22460	COG1012	belongs to the aldehyde dehydrogenase family
SAM23877_RS22480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SAM23877_RS22505	COG4770	biotin carboxylase activity
SAM23877_RS22515	COG0424	maF-like protein
SAM23877_RS22525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SAM23877_RS22535	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SAM23877_RS22545	COG1024	Enoyl-CoA hydratase
SAM23877_RS22555	COG2986	histidine ammonia-lyase
SAM23877_RS22575	COG1404	Belongs to the peptidase S8 family
SAM23877_RS22610	COG1064	alcohol dehydrogenase
SAM23877_RS22615	COG1090	epimerase
SAM23877_RS22635	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SAM23877_RS22660	COG2255	four-way junction helicase activity
SAM23877_RS22665	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SAM23877_RS22680	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SAM23877_RS22690	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SAM23877_RS22705	COG1331	Highly conserved protein containing a thioredoxin domain
SAM23877_RS22735	COG1309	transcriptional regulator
SAM23877_RS22745	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
SAM23877_RS22760	COG0436	Aminotransferase
SAM23877_RS22765	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SAM23877_RS22780	COG1414	Transcriptional regulator
SAM23877_RS22785	COG0251	oxidation-reduction process
SAM23877_RS22790	COG2610	gluconate transmembrane transporter activity
SAM23877_RS22835	COG2894	cell division
SAM23877_RS22905	COG2226	methyltransferase
SAM23877_RS22915	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SAM23877_RS22920	COG0741	lytic transglycosylase activity
SAM23877_RS22930	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SAM23877_RS22935	COG0450	alkyl hydroperoxide reductase
SAM23877_RS22950	COG1136	(ABC) transporter
SAM23877_RS22970	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SAM23877_RS22985	COG0114	fumarate hydratase activity
SAM23877_RS22990	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SAM23877_RS22990	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SAM23877_RS23015	COG0778	Nitroreductase
SAM23877_RS23030	COG1722	exodeoxyribonuclease VII activity
SAM23877_RS23035	COG1570	exodeoxyribonuclease VII activity
SAM23877_RS23045	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SAM23877_RS23060	COG0012	GTP binding
SAM23877_RS23090	COG2409	Drug exporters of the RND superfamily
SAM23877_RS23090	COG1033	growth of symbiont in host cell
SAM23877_RS23095	COG3833	ABC-type maltose transport systems, permease component
SAM23877_RS23100	COG1175	transmembrane transport
SAM23877_RS23110	COG3250	beta-galactosidase activity
SAM23877_RS23115	COG1609	Transcriptional regulator
SAM23877_RS23125	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SAM23877_RS23130	COG0583	DNA-binding transcription factor activity
SAM23877_RS23180	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SAM23877_RS23185	COG1053	succinate dehydrogenase
SAM23877_RS23205	COG1217	gtp-binding protein TYPA
SAM23877_RS23210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SAM23877_RS23215	COG4166	transmembrane transport
SAM23877_RS23220	COG0601	transmembrane transport
SAM23877_RS23225	COG0444	Belongs to the ABC transporter superfamily
SAM23877_RS23230	COG4608	Belongs to the ABC transporter superfamily
SAM23877_RS23235	COG4608	Belongs to the ABC transporter superfamily
SAM23877_RS23240	COG0444	Belongs to the ABC transporter superfamily
SAM23877_RS23250	COG0747	negative chemotaxis
SAM23877_RS23255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SAM23877_RS23265	COG0601	transmembrane transport
SAM23877_RS23270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SAM23877_RS23275	COG0444	Belongs to the ABC transporter superfamily
SAM23877_RS23280	COG4608	Belongs to the ABC transporter superfamily
SAM23877_RS23295	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SAM23877_RS23340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SAM23877_RS23350	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SAM23877_RS23360	COG2818	Glycosylase
SAM23877_RS23365	COG1024	Enoyl-CoA hydratase
SAM23877_RS23375	COG1595	DNA-templated transcription, initiation
SAM23877_RS23385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SAM23877_RS23390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SAM23877_RS23415	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SAM23877_RS23425	COG0598	Magnesium transport protein CorA
SAM23877_RS23435	COG2814	Major facilitator Superfamily
SAM23877_RS23450	COG2095	MarC family integral membrane protein
SAM23877_RS23455	COG1432	Conserved Protein
SAM23877_RS23530	COG0596	Alpha beta hydrolase
SAM23877_RS23555	COG0210	DNA helicase
SAM23877_RS23565	COG2816	NAD+ diphosphatase activity
SAM23877_RS23590	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SAM23877_RS23640	COG3480	Lon protease (S16) C-terminal proteolytic domain
SAM23877_RS23650	COG1615	UPF0182 protein
SAM23877_RS23675	COG0753	catalase activity
SAM23877_RS23685	COG0483	inositol monophosphate 1-phosphatase activity
SAM23877_RS23705	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SAM23877_RS23715	COG2135	peptidase activity
SAM23877_RS23725	COG1595	DNA-templated transcription, initiation
SAM23877_RS23730	COG5662	AntiSigma factor
SAM23877_RS23750	COG0242	peptide deformylase activity
SAM23877_RS23760	COG2124	cytochrome p450
SAM23877_RS23800	COG2188	Transcriptional regulator
SAM23877_RS23805	COG2182	Extracellular solute-binding protein
SAM23877_RS23810	COG1175	transmembrane transport
SAM23877_RS23815	COG0395	ABC-type sugar transport system, permease component
SAM23877_RS23820	COG1472	Belongs to the glycosyl hydrolase 3 family
SAM23877_RS23825	COG0363	glucosamine-6-phosphate deaminase activity
SAM23877_RS23830	COG1028	Short-chain dehydrogenase reductase Sdr
SAM23877_RS23850	COG1597	lipid kinase activity
SAM23877_RS23860	COG1191	sigma factor activity
SAM23877_RS23890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SAM23877_RS23895	COG0142	geranyltranstransferase activity
SAM23877_RS23920	COG4106	trans-aconitate 2-methyltransferase activity
SAM23877_RS23925	COG1126	abc transporter atp-binding protein
SAM23877_RS23940	COG0281	malic enzyme
SAM23877_RS23945	COG0604	alcohol dehydrogenase
SAM23877_RS23980	COG0567	Dehydrogenase, E1 component
SAM23877_RS23980	COG0508	dehydrogenase complex catalyzes the overall conversion of
SAM23877_RS23985	COG2205	protein histidine kinase activity
SAM23877_RS23990	COG0745	RESPONSE REGULATOR receiver
SAM23877_RS24000	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SAM23877_RS24045	COG0791	NLP P60 protein
SAM23877_RS24045	COG3883	PFAM NLP P60 protein
SAM23877_RS24055	COG1309	transcriptional regulator
SAM23877_RS24085	COG2205	protein histidine kinase activity
SAM23877_RS24100	COG1793	dna ligase
SAM23877_RS24100	COG3285	dna ligase
SAM23877_RS24105	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SAM23877_RS24120	COG3467	pyridoxamine 5'-phosphate
SAM23877_RS24130	COG2867	negative regulation of translational initiation
SAM23877_RS24135	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SAM23877_RS24140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SAM23877_RS24145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SAM23877_RS24150	COG0662	Cupin 2, conserved barrel domain protein
SAM23877_RS24155	COG2329	Antibiotic biosynthesis monooxygenase
SAM23877_RS24160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SAM23877_RS24175	COG0745	RESPONSE REGULATOR receiver
SAM23877_RS24180	COG0018	arginyl-trna synthetase
SAM23877_RS24180	COG0018	arginyl-trna synthetase
SAM23877_RS24185	COG0019	diaminopimelate decarboxylase activity
SAM23877_RS24190	COG0460	homoserine dehydrogenase
SAM23877_RS24195	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SAM23877_RS24200	COG0083	homoserine kinase activity
SAM23877_RS24220	COG0254	rRNA binding
SAM23877_RS24225	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SAM23877_RS24230	COG2890	protein-(glutamine-N5) methyltransferase activity
SAM23877_RS24240	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SAM23877_RS24245	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SAM23877_RS24265	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SAM23877_RS24270	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SAM23877_RS24275	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SAM23877_RS24280	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SAM23877_RS24285	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SAM23877_RS24290	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SAM23877_RS24295	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SAM23877_RS24310	COG2197	response regulator
SAM23877_RS24315	COG4585	Histidine kinase
SAM23877_RS24350	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAM23877_RS24365	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
SAM23877_RS24400	COG1131	(ABC) transporter
SAM23877_RS24420	COG0183	Belongs to the thiolase family
SAM23877_RS24440	COG0745	RESPONSE REGULATOR receiver
SAM23877_RS24445	COG2205	protein histidine kinase activity
SAM23877_RS24490	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SAM23877_RS24490	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SAM23877_RS24525	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SAM23877_RS24530	COG0857	belongs to the CobB CobQ family
SAM23877_RS24530	COG0280	phosphate acetyltransferase
SAM23877_RS24535	COG0205	6-phosphofructokinase activity
SAM23877_RS24545	COG0395	ABC-type sugar transport system, permease component
SAM23877_RS24560	COG4565	transcriptional regulatory protein
SAM23877_RS24565	COG4191	Histidine kinase
SAM23877_RS24570	COG1301	dicarboxylic acid transport
SAM23877_RS24595	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SAM23877_RS24600	COG3281	Trehalose synthase
SAM23877_RS24605	COG0366	Alpha amylase catalytic
SAM23877_RS24610	COG0366	Alpha amylase catalytic
SAM23877_RS24615	COG0058	SHG alpha-glucan phosphorylase activity
SAM23877_RS24635	COG1132	(ABC) transporter
SAM23877_RS24640	COG1132	(ABC) transporter
SAM23877_RS24645	COG1132	(ABC) transporter
SAM23877_RS24650	COG1132	(ABC) transporter
SAM23877_RS24655	COG3119	arylsulfatase activity
SAM23877_RS24700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SAM23877_RS24705	COG3757	hydrolase, family 25
SAM23877_RS24705	COG3409	Peptidoglycan-binding domain 1 protein
SAM23877_RS24710	COG0477	Major facilitator Superfamily
SAM23877_RS24715	COG1760	l-serine dehydratase
SAM23877_RS24720	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SAM23877_RS24725	COG0509	glycine decarboxylation via glycine cleavage system
SAM23877_RS24730	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SAM23877_RS24750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SAM23877_RS24765	COG0444	Belongs to the ABC transporter superfamily
SAM23877_RS24770	COG4608	Belongs to the ABC transporter superfamily
SAM23877_RS24775	COG2860	membrane
SAM23877_RS24785	COG0789	Transcriptional regulator
SAM23877_RS24815	COG0482	sulfurtransferase activity
SAM23877_RS24830	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SAM23877_RS24860	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SAM23877_RS24880	COG1611	Belongs to the LOG family
SAM23877_RS24885	COG4221	oxidoreductase activity
SAM23877_RS24895	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SAM23877_RS24905	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SAM23877_RS24910	COG0154	amidase activity
SAM23877_RS24920	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SAM23877_RS24925	COG2409	Drug exporters of the RND superfamily
SAM23877_RS24930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SAM23877_RS24945	COG2197	response regulator
SAM23877_RS24955	COG2133	pyrroloquinoline quinone binding
SAM23877_RS24960	COG0667	Aldo Keto reductase
SAM23877_RS24980	COG0440	acetolactate synthase activity
SAM23877_RS24985	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SAM23877_RS24990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SAM23877_RS24995	COG0477	Major facilitator Superfamily
SAM23877_RS25005	COG3835	regulator
SAM23877_RS25010	COG0506	proline dehydrogenase activity
SAM23877_RS25015	COG1012	belongs to the aldehyde dehydrogenase family
SAM23877_RS25025	COG0473	3-isopropylmalate dehydrogenase activity
SAM23877_RS25030	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SAM23877_RS25040	COG0831	urea catabolic process
SAM23877_RS25040	COG0832	Belongs to the urease beta subunit family
SAM23877_RS25045	COG0804	urea catabolic process
SAM23877_RS25050	COG2957	Belongs to the agmatine deiminase family
SAM23877_RS25060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SAM23877_RS25085	COG2353	YceI-like domain
SAM23877_RS25090	COG5492	domain, Protein
SAM23877_RS25095	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SAM23877_RS25115	COG2018	Roadblock/LC7 domain
SAM23877_RS25135	COG2018	Roadblock/LC7 domain
SAM23877_RS25140	COG5002	protein histidine kinase activity
SAM23877_RS25145	COG0179	Fumarylacetoacetate (FAA) hydrolase
SAM23877_RS25150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SAM23877_RS25185	COG1414	Transcriptional regulator
SAM23877_RS25190	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SAM23877_RS25195	COG0066	3-isopropylmalate dehydratase activity
SAM23877_RS25205	COG0776	regulation of translation
SAM23877_RS25215	COG1920	GTP binding
SAM23877_RS25225	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SAM23877_RS25230	COG1181	Belongs to the D-alanine--D-alanine ligase family
SAM23877_RS25245	COG0351	phosphomethylpyrimidine kinase
SAM23877_RS25255	COG1461	Dihydroxyacetone kinase
SAM23877_RS25265	COG0742	ribosomal rna small subunit methyltransferase
SAM23877_RS25270	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SAM23877_RS25285	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SAM23877_RS25290	COG0571	ribonuclease III activity
SAM23877_RS25295	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SAM23877_RS25300	COG1733	regulation of RNA biosynthetic process
SAM23877_RS25310	COG2340	Cysteine-rich secretory protein family
SAM23877_RS25315	COG1254	Belongs to the acylphosphatase family
SAM23877_RS25330	COG0477	Major facilitator Superfamily
SAM23877_RS25365	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SAM23877_RS25375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SAM23877_RS25395	COG0228	four-way junction DNA binding
SAM23877_RS25400	COG1837	Belongs to the UPF0109 family
SAM23877_RS25405	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SAM23877_RS25410	COG0336	Belongs to the RNA methyltransferase TrmD family
SAM23877_RS25415	COG0335	large ribosomal subunit rRNA binding
SAM23877_RS25430	COG0681	Belongs to the peptidase S26 family
SAM23877_RS25435	COG0681	Belongs to the peptidase S26 family
SAM23877_RS25440	COG1051	belongs to the nudix hydrolase family
SAM23877_RS25450	COG0792	nuclease activity
SAM23877_RS25465	COG1191	sigma factor activity
SAM23877_RS25480	COG0052	Belongs to the universal ribosomal protein uS2 family
SAM23877_RS25485	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SAM23877_RS25490	COG0528	UMP kinase activity
SAM23877_RS25495	COG0233	cytoplasmic translational termination
SAM23877_RS25500	COG0575	Belongs to the CDS family
SAM23877_RS25505	COG1247	-acetyltransferase
SAM23877_RS25510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SAM23877_RS25515	COG0798	PFAM Bile acid sodium symporter
SAM23877_RS25520	COG0640	Transcriptional regulator
SAM23877_RS25530	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SAM23877_RS25540	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
SAM23877_RS25545	COG3842	ATPase activity
SAM23877_RS25580	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SAM23877_RS25590	COG1012	belongs to the aldehyde dehydrogenase family
SAM23877_RS25605	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SAM23877_RS25630	COG3842	ATPase activity
SAM23877_RS25635	COG1176	ABC-type spermidine putrescine transport system, permease component I
SAM23877_RS25640	COG1177	transmembrane transport
SAM23877_RS25645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SAM23877_RS25675	COG2508	Transcriptional regulator
SAM23877_RS25680	COG1012	belongs to the aldehyde dehydrogenase family
SAM23877_RS25685	COG0438	transferase activity, transferring glycosyl groups
SAM23877_RS25700	COG4209	transmembrane transport
SAM23877_RS25705	COG0395	ABC-type sugar transport system, permease component
SAM23877_RS25735	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SAM23877_RS25740	COG0750	zinc metalloprotease
SAM23877_RS25745	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SAM23877_RS25760	COG0442	prolyl-tRNA aminoacylation
SAM23877_RS25780	COG0779	Required for maturation of 30S ribosomal subunits
SAM23877_RS25790	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SAM23877_RS25800	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SAM23877_RS25805	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SAM23877_RS25820	COG0455	bacterial-type flagellum organization
SAM23877_RS25835	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SAM23877_RS25840	COG1185	polyribonucleotide nucleotidyltransferase activity
SAM23877_RS25845	COG0612	Peptidase, M16
SAM23877_RS25850	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SAM23877_RS25870	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SAM23877_RS25875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SAM23877_RS25880	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SAM23877_RS25910	COG2208	phosphoserine phosphatase activity
SAM23877_RS25910	COG2770	Histidine kinase
SAM23877_RS25915	COG0784	Response regulator, receiver
SAM23877_RS25915	COG2205	protein histidine kinase activity
SAM23877_RS25925	COG1674	ftsk spoiiie
SAM23877_RS25935	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SAM23877_RS25945	COG1058	Belongs to the CinA family
SAM23877_RS25945	COG1546	Belongs to the CinA family
SAM23877_RS25950	COG1396	sequence-specific DNA binding
SAM23877_RS25955	COG0783	Belongs to the Dps family
SAM23877_RS25965	COG0640	Transcriptional regulator
SAM23877_RS25975	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SAM23877_RS25980	COG1201	RNA secondary structure unwinding
SAM23877_RS25985	COG1917	Cupin 2, conserved barrel domain protein
SAM23877_RS25985	COG2207	Transcriptional regulator
SAM23877_RS26010	COG0628	permease
SAM23877_RS26045	COG0765	amino acid transport
SAM23877_RS26050	COG0765	amino acid transport
SAM23877_RS26055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SAM23877_RS26060	COG1126	abc transporter atp-binding protein
SAM23877_RS26065	COG0745	RESPONSE REGULATOR receiver
SAM23877_RS26070	COG2205	protein histidine kinase activity
SAM23877_RS26100	COG2197	response regulator
SAM23877_RS26105	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SAM23877_RS26125	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SAM23877_RS26135	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SAM23877_RS26140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SAM23877_RS26150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SAM23877_RS26185	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SAM23877_RS26190	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SAM23877_RS26195	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SAM23877_RS26210	COG0588	phosphoglycerate mutase activity
SAM23877_RS26230	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SAM23877_RS26265	COG3842	ATPase activity
SAM23877_RS26270	COG2186	Transcriptional regulator
SAM23877_RS26275	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SAM23877_RS26290	COG0187	DNA topoisomerase II activity
SAM23877_RS26300	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SAM23877_RS26305	COG4565	transcriptional regulatory protein
SAM23877_RS26310	COG3290	protein histidine kinase activity
SAM23877_RS26335	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SAM23877_RS26340	COG0612	Peptidase, M16
SAM23877_RS26355	COG1802	Transcriptional regulator
SAM23877_RS26360	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SAM23877_RS26380	COG1435	thymidine kinase activity
SAM23877_RS26415	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SAM23877_RS26425	COG0745	RESPONSE REGULATOR receiver
SAM23877_RS26430	COG2205	protein histidine kinase activity
SAM23877_RS26455	COG0756	dUTP diphosphatase activity
SAM23877_RS26495	COG0569	domain protein
SAM23877_RS26500	COG0531	amino acid
SAM23877_RS26505	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SAM23877_RS26515	COG3654	unkown
SAM23877_RS26565	COG3693	PFAM glycoside hydrolase, family 10
SAM23877_RS26580	COG0667	Aldo Keto reductase
SAM23877_RS26590	COG4124	Belongs to the glycosyl hydrolase 26 family
SAM23877_RS26605	COG1819	glycosyl
SAM23877_RS26610	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAM23877_RS26635	COG0667	Aldo Keto reductase
SAM23877_RS26650	COG1819	glycosyl
SAM23877_RS26670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SAM23877_RS26680	COG0488	(ABC) transporter
SAM23877_RS26720	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SAM23877_RS26730	COG2124	cytochrome p450
SAM23877_RS26775	COG2226	methyltransferase
SAM23877_RS26785	COG1819	glycosyl
SAM23877_RS26825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SAM23877_RS26910	COG2197	response regulator
SAM23877_RS26915	COG4585	Histidine kinase
SAM23877_RS26920	COG0531	amino acid
SAM23877_RS26930	COG0477	Major facilitator Superfamily
SAM23877_RS26935	COG1122	ATPase activity
SAM23877_RS26945	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
SAM23877_RS26950	COG0310	cobalt ion transport
SAM23877_RS26955	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SAM23877_RS26970	COG1799	cell septum assembly
SAM23877_RS27000	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SAM23877_RS27010	COG2255	four-way junction helicase activity
SAM23877_RS27020	COG0475	glutathione-regulated potassium exporter activity
SAM23877_RS27045	COG2235	arginine
SAM23877_RS27050	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SAM23877_RS27055	COG0531	amino acid
SAM23877_RS27065	COG1024	Enoyl-CoA hydratase
SAM23877_RS27085	COG1960	acyl-CoA dehydrogenase activity
SAM23877_RS27115	COG0659	secondary active sulfate transmembrane transporter activity
SAM23877_RS27140	COG2319	Wd-40 repeat
SAM23877_RS27150	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SAM23877_RS27155	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SAM23877_RS27180	COG1653	transport
SAM23877_RS27185	COG1175	transmembrane transport
SAM23877_RS27190	COG0395	ABC-type sugar transport system, permease component
SAM23877_RS27195	COG1940	carbohydrate kinase activity
SAM23877_RS27200	COG4213	ABC transporter substrate-binding protein
SAM23877_RS27210	COG4214	carbohydrate transport
SAM23877_RS27215	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SAM23877_RS27220	COG0531	amino acid
SAM23877_RS27255	COG1316	TRANSCRIPTIONal
SAM23877_RS27260	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SAM23877_RS27285	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAM23877_RS27285	COG1024	Enoyl-CoA hydratase
SAM23877_RS27290	COG0183	Belongs to the thiolase family
SAM23877_RS27295	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SAM23877_RS27310	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SAM23877_RS27330	COG0446	pyridine nucleotide-disulphide oxidoreductase
SAM23877_RS27340	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SAM23877_RS27345	COG3253	May function as heme-dependent peroxidase
SAM23877_RS27360	COG3220	belongs to the UPF0276 family
SAM23877_RS27385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SAM23877_RS27385	COG0723	plastoquinol--plastocyanin reductase activity
SAM23877_RS27395	COG0330	HflC and HflK could
SAM23877_RS27430	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SAM23877_RS27435	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SAM23877_RS27440	COG2205	protein histidine kinase activity
SAM23877_RS27445	COG0745	RESPONSE REGULATOR receiver
SAM23877_RS27455	COG1174	glycine betaine transport
SAM23877_RS27460	COG1174	glycine betaine transport
SAM23877_RS27495	COG1309	transcriptional regulator
SAM23877_RS27520	COG3173	Aminoglycoside phosphotransferase
SAM23877_RS27545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SAM23877_RS27550	COG0583	DNA-binding transcription factor activity
SAM23877_RS27585	COG1175	transmembrane transport
SAM23877_RS27600	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SAM23877_RS27630	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
SAM23877_RS27650	COG0529	Catalyzes the synthesis of activated sulfate
SAM23877_RS27655	COG0175	sulfate reduction
SAM23877_RS27685	COG1960	acyl-CoA dehydrogenase activity
SAM23877_RS27710	COG4977	sequence-specific DNA binding
SAM23877_RS27710	COG1917	Cupin 2, conserved barrel domain protein
SAM23877_RS27745	COG1131	(ABC) transporter
SAM23877_RS27805	COG0714	Associated with various cellular activities
SAM23877_RS27820	COG2040	homocysteine
SAM23877_RS27865	COG0277	FAD linked oxidase domain protein
SAM23877_RS27880	COG1162	GTPase activity
SAM23877_RS27890	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SAM23877_RS27910	COG0028	Belongs to the TPP enzyme family
SAM23877_RS27930	COG1802	Transcriptional regulator
SAM23877_RS27970	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SAM23877_RS27980	COG2197	response regulator
SAM23877_RS27985	COG3851	Histidine kinase
SAM23877_RS28015	COG3835	regulator
SAM23877_RS28030	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SAM23877_RS28035	COG2252	PERMEase
SAM23877_RS28055	COG0726	polysaccharide deacetylase
SAM23877_RS28060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SAM23877_RS28065	COG2192	nodulation
SAM23877_RS28075	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SAM23877_RS28080	COG0859	PFAM glycosyl transferase family 9
SAM23877_RS28085	COG0438	transferase activity, transferring glycosyl groups
SAM23877_RS28090	COG0297	glycogen (starch) synthase activity
SAM23877_RS28095	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SAM23877_RS28100	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SAM23877_RS28100	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SAM23877_RS28105	COG0859	PFAM glycosyl transferase family 9
SAM23877_RS28145	COG2197	response regulator
SAM23877_RS28150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SAM23877_RS28155	COG0318	PFAM AMP-dependent synthetase and ligase
SAM23877_RS28180	COG0318	PFAM AMP-dependent synthetase and ligase
SAM23877_RS28215	COG3960	tartronate-semialdehyde synthase activity
SAM23877_RS28230	COG0753	catalase activity
SAM23877_RS28235	COG2084	Dehydrogenase
SAM23877_RS28240	COG3622	Belongs to the hyi family
SAM23877_RS28260	COG2351	hydroxyisourate hydrolase activity
SAM23877_RS28270	COG2233	PERMEase
SAM23877_RS28290	COG1733	regulation of RNA biosynthetic process
SAM23877_RS28305	COG0406	alpha-ribazole phosphatase activity
SAM23877_RS28310	COG0436	Aminotransferase
SAM23877_RS28330	COG4264	IucA IucC family
SAM23877_RS28345	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SAM23877_RS28360	COG1414	Transcriptional regulator
SAM23877_RS28365	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SAM23877_RS28370	COG4266	Belongs to the allantoicase family
SAM23877_RS28375	COG1028	Short-chain dehydrogenase reductase Sdr
SAM23877_RS28395	COG2197	response regulator
SAM23877_RS28405	COG2188	Transcriptional regulator
SAM23877_RS28425	COG1940	carbohydrate kinase activity
SAM23877_RS28435	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SAM23877_RS28465	COG1301	dicarboxylic acid transport
SAM23877_RS28470	COG4948	Mandelate Racemase Muconate Lactonizing
SAM23877_RS28480	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SAM23877_RS28485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAM23877_RS28490	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SAM23877_RS28495	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SAM23877_RS28505	COG1181	Belongs to the D-alanine--D-alanine ligase family
SAM23877_RS28510	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SAM23877_RS28565	COG0640	Transcriptional regulator
SAM23877_RS28575	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SAM23877_RS28580	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SAM23877_RS28600	COG0405	Gamma-glutamyltransferase
SAM23877_RS28605	COG0542	response to heat
SAM23877_RS28625	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SAM23877_RS28640	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SAM23877_RS28645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAM23877_RS28650	COG1953	Uracil, thiamine, allantoin
SAM23877_RS28660	COG2226	methyltransferase
SAM23877_RS28675	COG2197	response regulator
SAM23877_RS28700	COG0483	inositol monophosphate 1-phosphatase activity
SAM23877_RS28710	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SAM23877_RS28720	COG0601	transmembrane transport
SAM23877_RS28725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SAM23877_RS28730	COG0444	Belongs to the ABC transporter superfamily
SAM23877_RS28750	COG0640	Transcriptional regulator
SAM23877_RS28755	COG2217	Heavy metal translocating P-type atpase
SAM23877_RS28765	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SAM23877_RS28775	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SAM23877_RS28785	COG1929	Belongs to the glycerate kinase type-1 family
SAM23877_RS28795	COG0688	phosphatidylethanolamine metabolic process
SAM23877_RS28800	COG1960	acyl-CoA dehydrogenase activity
SAM23877_RS28810	COG2301	Belongs to the HpcH HpaI aldolase family
SAM23877_RS28815	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SAM23877_RS28815	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SAM23877_RS28830	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAM23877_RS28845	COG0596	Alpha beta hydrolase
SAM23877_RS29020	COG0739	heme binding
SAM23877_RS29055	COG2755	lipolytic protein G-D-S-L family
SAM23877_RS29145	COG0270	DNA (cytosine-5-)-methyltransferase activity
SAM23877_RS29350	COG2362	D-Aminopeptidase
SAM23877_RS29355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SAM23877_RS29365	COG1619	proteins homologs of microcin C7 resistance protein MccF
SAM23877_RS29395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAM23877_RS29405	COG3959	Transketolase, thiamine diphosphate binding domain
SAM23877_RS29475	COG1597	lipid kinase activity
SAM23877_RS29495	COG0693	protein deglycase activity
SAM23877_RS29500	COG0517	IMP dehydrogenase activity
SAM23877_RS29510	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SAM23877_RS29525	COG0028	Belongs to the TPP enzyme family
SAM23877_RS29570	COG0531	amino acid
SAM23877_RS29590	COG1140	nitrate reductase beta subunit
SAM23877_RS29620	COG2154	pterin-4-alpha-carbinolamine dehydratase
SAM23877_RS29625	COG2226	methyltransferase
SAM23877_RS29630	COG3401	FG-GAP repeat protein
SAM23877_RS29645	COG4733	cellulase activity
SAM23877_RS29645	COG5297	Belongs to the glycosyl hydrolase family 6
SAM23877_RS29650	COG5297	Belongs to the glycosyl hydrolase family 6
SAM23877_RS29655	COG2226	methyltransferase
SAM23877_RS29660	COG0656	L-ascorbic acid biosynthetic process
SAM23877_RS29685	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SAM23877_RS29695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SAM23877_RS29710	COG1129	ABC transporter
SAM23877_RS29715	COG1172	Belongs to the binding-protein-dependent transport system permease family
SAM23877_RS29725	COG0673	inositol 2-dehydrogenase activity
SAM23877_RS29790	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SAM23877_RS29805	COG0714	Associated with various cellular activities
SAM23877_RS29810	COG3552	Protein containing von Willebrand factor type A (VWA) domain
SAM23877_RS29850	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SAM23877_RS29885	COG0747	negative chemotaxis
SAM23877_RS29890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SAM23877_RS29905	COG1183	phosphatidylcholine synthase activity
SAM23877_RS29920	COG0297	glycogen (starch) synthase activity
SAM23877_RS29940	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SAM23877_RS29950	COG0477	Major facilitator Superfamily
SAM23877_RS29960	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SAM23877_RS29965	COG1082	Xylose isomerase domain protein TIM barrel
SAM23877_RS29965	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SAM23877_RS29975	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SAM23877_RS29980	COG0166	Belongs to the GPI family
SAM23877_RS29995	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SAM23877_RS30010	COG1486	melibiose metabolic process
SAM23877_RS30020	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SAM23877_RS30065	COG3938	Belongs to the proline racemase family
SAM23877_RS30075	COG1414	Transcriptional regulator
SAM23877_RS30080	COG0515	serine threonine protein kinase
SAM23877_RS30090	COG1132	(ABC) transporter
SAM23877_RS30095	COG1132	(ABC) transporter
SAM23877_RS30100	COG2197	response regulator
SAM23877_RS30105	COG0477	Major facilitator Superfamily
SAM23877_RS30110	COG3511	phospholipase C
SAM23877_RS30140	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SAM23877_RS30145	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SAM23877_RS30150	COG3485	protocatechuate 3,4-dioxygenase
SAM23877_RS30155	COG3485	protocatechuate 3,4-dioxygenase
SAM23877_RS30160	COG0183	Belongs to the thiolase family
SAM23877_RS30180	COG1470	cell adhesion involved in biofilm formation
SAM23877_RS30190	COG1793	dna ligase
SAM23877_RS30235	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SAM23877_RS30240	COG0488	(ABC) transporter
SAM23877_RS30255	COG4447	cellulose binding
SAM23877_RS30270	COG1515	deoxyribonuclease V activity
SAM23877_RS30285	COG3268	Saccharopine dehydrogenase
SAM23877_RS30290	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SAM23877_RS30295	COG0183	Belongs to the thiolase family
SAM23877_RS30300	COG1024	Enoyl-CoA hydratase
SAM23877_RS30300	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAM23877_RS30310	COG1113	amino acid transport
SAM23877_RS30315	COG2936	dipeptidyl-peptidase activity
SAM23877_RS30325	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SAM23877_RS30340	COG0488	(ABC) transporter
SAM23877_RS30345	COG2183	response to ionizing radiation
SAM23877_RS30365	COG1024	Enoyl-CoA hydratase
SAM23877_RS30375	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SAM23877_RS30415	COG1134	teichoic acid transport
SAM23877_RS30420	COG1562	ergosterol biosynthetic process
SAM23877_RS30430	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SAM23877_RS30440	COG1657	PFAM Prenyltransferase squalene oxidase
SAM23877_RS30455	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SAM23877_RS30460	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SAM23877_RS30480	COG2365	Tyrosine phosphatase family
SAM23877_RS30500	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SAM23877_RS30535	COG1063	alcohol dehydrogenase
SAM23877_RS30540	COG0156	8-amino-7-oxononanoate synthase activity
SAM23877_RS30545	COG0583	DNA-binding transcription factor activity
SAM23877_RS30570	COG2111	Na H antiporter
SAM23877_RS30570	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SAM23877_RS30575	COG1006	Multisubunit Na H antiporter MnhC subunit
SAM23877_RS30580	COG0651	ATP synthesis coupled electron transport
SAM23877_RS30595	COG1320	monovalent cation:proton antiporter activity
SAM23877_RS30610	COG0174	glutamine synthetase
SAM23877_RS30630	COG2267	carboxylic ester hydrolase activity
SAM23877_RS30635	COG0183	Belongs to the thiolase family
SAM23877_RS30640	COG0318	PFAM AMP-dependent synthetase and ligase
SAM23877_RS30645	COG0455	bacterial-type flagellum organization
SAM23877_RS30680	COG1122	ATPase activity
SAM23877_RS30730	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SAM23877_RS30735	COG1518	maintenance of DNA repeat elements
SAM23877_RS30900	COG2188	Transcriptional regulator
SAM23877_RS30905	COG3962	Belongs to the TPP enzyme family
SAM23877_RS30910	COG3718	enzyme involved in inositol metabolism
SAM23877_RS30920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SAM23877_RS30945	COG2764	glyoxalase bleomycin resistance protein dioxygenase
SAM23877_RS30950	COG0673	inositol 2-dehydrogenase activity
SAM23877_RS30955	COG0673	inositol 2-dehydrogenase activity
SAM23877_RS30965	COG2186	Transcriptional regulator
SAM23877_RS30970	COG0385	Bile acid
SAM23877_RS30985	COG2197	response regulator
SAM23877_RS30995	COG1404	Belongs to the peptidase S8 family
SAM23877_RS31015	COG2838	Isocitrate dehydrogenase
SAM23877_RS31020	COG0668	transmembrane transport
SAM23877_RS31030	COG1132	(ABC) transporter
SAM23877_RS31040	COG0366	Alpha amylase catalytic
SAM23877_RS31045	COG0395	ABC-type sugar transport system, permease component
SAM23877_RS31050	COG1175	transmembrane transport
SAM23877_RS31055	COG1653	transport
SAM23877_RS31080	COG2186	Transcriptional regulator
SAM23877_RS31085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SAM23877_RS31090	COG0800	Aldolase
SAM23877_RS31095	COG4948	Mandelate Racemase Muconate Lactonizing
SAM23877_RS31100	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SAM23877_RS31105	COG1231	oxidoreductase activity
SAM23877_RS31115	COG1063	alcohol dehydrogenase
SAM23877_RS31120	COG0477	Major facilitator Superfamily
SAM23877_RS31125	COG0246	Mannitol dehydrogenase
SAM23877_RS31140	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAM23877_RS31145	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SAM23877_RS31150	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SAM23877_RS31155	COG0583	DNA-binding transcription factor activity
SAM23877_RS31160	COG0183	Belongs to the thiolase family
SAM23877_RS31165	COG0477	Major facilitator Superfamily
SAM23877_RS31210	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SAM23877_RS31225	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SAM23877_RS31245	COG0297	glycogen (starch) synthase activity
SAM23877_RS31250	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SAM23877_RS31275	COG0154	amidase activity
SAM23877_RS31295	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SAM23877_RS31325	COG0596	Alpha beta hydrolase
SAM23877_RS31330	COG0531	amino acid
SAM23877_RS31340	COG0726	polysaccharide deacetylase
SAM23877_RS31380	COG0583	DNA-binding transcription factor activity
SAM23877_RS31390	COG1053	succinate dehydrogenase
SAM23877_RS31395	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SAM23877_RS31420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAM23877_RS31430	COG3360	Dodecin
SAM23877_RS31435	COG2182	Extracellular solute-binding protein
SAM23877_RS31440	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SAM23877_RS31445	COG0121	glutamine amidotransferase
SAM23877_RS31450	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SAM23877_RS31470	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SAM23877_RS31500	COG0596	Alpha beta hydrolase
SAM23877_RS31505	COG3629	intracellular signal transduction
SAM23877_RS31505	COG3903	Transcriptional regulator
SAM23877_RS31515	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SAM23877_RS31540	COG1609	Transcriptional regulator
SAM23877_RS31545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SAM23877_RS31555	COG0242	peptide deformylase activity
SAM23877_RS31575	COG0318	PFAM AMP-dependent synthetase and ligase
SAM23877_RS31580	COG1132	(ABC) transporter
SAM23877_RS31585	COG1132	(ABC) transporter
SAM23877_RS31590	COG2197	response regulator
SAM23877_RS31600	COG1012	belongs to the aldehyde dehydrogenase family
SAM23877_RS31610	COG0167	dihydroorotate dehydrogenase activity
SAM23877_RS31625	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SAM23877_RS31630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SAM23877_RS31645	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SAM23877_RS31660	COG4106	trans-aconitate 2-methyltransferase activity
SAM23877_RS31675	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SAM23877_RS31700	COG0500	methyltransferase
SAM23877_RS31745	COG1846	Transcriptional regulator
SAM23877_RS31750	COG2409	Drug exporters of the RND superfamily
SAM23877_RS31775	COG0668	transmembrane transport
SAM23877_RS31785	COG0514	ATP-dependent DNA helicase (RecQ)
SAM23877_RS31820	COG3540	Alkaline phosphatase
SAM23877_RS31860	COG1136	(ABC) transporter
SAM23877_RS31860	COG0577	efflux transmembrane transporter activity
SAM23877_RS31870	COG1609	Transcriptional regulator
SAM23877_RS31885	COG1357	PFAM Pentapeptide repeats (8 copies)
SAM23877_RS31895	COG1309	transcriptional regulator
SAM23877_RS31905	COG2706	6-phosphogluconolactonase activity
SAM23877_RS31950	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SAM23877_RS31950	COG1796	DNA polymerase
SAM23877_RS31955	COG1028	Short-chain dehydrogenase reductase Sdr
SAM23877_RS31985	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SAM23877_RS32025	COG2124	cytochrome p450
SAM23877_RS32040	COG0435	Glutathione S-transferase
SAM23877_RS32080	COG0667	Aldo Keto reductase
SAM23877_RS32095	COG3250	beta-galactosidase activity
SAM23877_RS32120	COG1304	FMN binding
SAM23877_RS32135	COG2890	protein-(glutamine-N5) methyltransferase activity
SAM23877_RS32150	COG0248	Ppx GppA phosphatase
SAM23877_RS32235	COG1028	Short-chain dehydrogenase reductase Sdr
SAM23877_RS32245	COG1028	Short-chain dehydrogenase reductase Sdr
SAM23877_RS32285	COG1309	transcriptional regulator
SAM23877_RS32315	COG0572	uridine kinase
SAM23877_RS32375	COG1819	glycosyl
SAM23877_RS32380	COG0789	Transcriptional regulator
SAM23877_RS32405	COG0673	inositol 2-dehydrogenase activity
SAM23877_RS32425	COG2508	Transcriptional regulator
SAM23877_RS32430	COG3547	Transposase (IS116 IS110 IS902 family)
SAM23877_RS32435	COG0410	ABC transporter
SAM23877_RS32440	COG0411	ABC transporter
SAM23877_RS32485	COG1132	(ABC) transporter
SAM23877_RS32530	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SAM23877_RS32535	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SAM23877_RS32540	COG2080	2 iron, 2 sulfur cluster binding
SAM23877_RS32555	COG1028	Short-chain dehydrogenase reductase Sdr
SAM23877_RS32560	COG1295	ribonuclease BN
SAM23877_RS32590	COG0477	Major facilitator Superfamily
SAM23877_RS32600	COG3290	protein histidine kinase activity
SAM23877_RS32640	COG0277	FAD linked oxidase domain protein
SAM23877_RS32645	COG1597	lipid kinase activity
SAM23877_RS32665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SAM23877_RS32670	COG0395	ABC-type sugar transport system, permease component
SAM23877_RS32675	COG1175	transmembrane transport
SAM23877_RS32745	COG1028	Short-chain dehydrogenase reductase Sdr
SAM23877_RS32760	COG3397	chitin binding
SAM23877_RS32780	COG2072	flavoprotein involved in K transport
SAM23877_RS32795	COG0488	(ABC) transporter
SAM23877_RS32820	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SAM23877_RS32840	COG2235	arginine
SAM23877_RS32890	COG0505	Belongs to the CarA family
SAM23877_RS32905	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SAM23877_RS32910	COG1191	sigma factor activity
SAM23877_RS32930	COG0783	Belongs to the Dps family
SAM23877_RS32935	COG0655	NAD(P)H dehydrogenase (quinone) activity
SAM23877_RS32955	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SAM23877_RS32985	COG1090	epimerase
SAM23877_RS32990	COG2124	cytochrome p450
SAM23877_RS32995	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SAM23877_RS33000	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SAM23877_RS33005	COG0142	geranyltranstransferase activity
SAM23877_RS33020	COG0142	geranyltranstransferase activity
SAM23877_RS33055	COG2271	Major facilitator Superfamily
SAM23877_RS33070	COG0789	Transcriptional regulator
SAM23877_RS33105	COG0745	RESPONSE REGULATOR receiver
SAM23877_RS33110	COG2205	protein histidine kinase activity
SAM23877_RS33115	COG2340	Cysteine-rich secretory protein family
SAM23877_RS33120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SAM23877_RS33125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SAM23877_RS33140	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
SAM23877_RS33165	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SAM23877_RS33170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SAM23877_RS33180	COG0438	transferase activity, transferring glycosyl groups
SAM23877_RS33200	COG0667	Aldo Keto reductase
SAM23877_RS33210	COG2326	polyphosphate kinase activity
SAM23877_RS33220	COG1196	nuclear chromosome segregation
SAM23877_RS33220	COG0739	heme binding
SAM23877_RS33220	COG0741	lytic transglycosylase activity
SAM23877_RS33240	COG0395	ABC-type sugar transport system, permease component
SAM23877_RS33250	COG2182	Extracellular solute-binding protein
SAM23877_RS33255	COG2188	Transcriptional regulator
SAM23877_RS33260	COG0673	inositol 2-dehydrogenase activity
SAM23877_RS33280	COG1278	Cold shock
SAM23877_RS33300	COG3386	PFAM SMP-30 Gluconolaconase
SAM23877_RS33335	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SAM23877_RS33345	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SAM23877_RS33355	COG0513	Belongs to the DEAD box helicase family
SAM23877_RS33380	COG3486	L-lysine 6-monooxygenase (NADPH) activity
SAM23877_RS33385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAM23877_RS33390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAM23877_RS33395	COG1120	ATPase activity
SAM23877_RS33400	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
SAM23877_RS33405	COG1132	(ABC) transporter
SAM23877_RS33415	COG1132	(ABC) transporter
SAM23877_RS33425	COG2382	esterase
SAM23877_RS33445	COG1984	allophanate hydrolase subunit 2
SAM23877_RS33450	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SAM23877_RS33455	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SAM23877_RS33470	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SAM23877_RS33480	COG2267	carboxylic ester hydrolase activity
SAM23877_RS33500	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SAM23877_RS33505	COG1263	PTS System
SAM23877_RS33505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SAM23877_RS33515	COG4172	Belongs to the ABC transporter superfamily
SAM23877_RS33550	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SAM23877_RS33555	COG1309	transcriptional regulator
SAM23877_RS33605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SAM23877_RS33615	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SAM23877_RS33620	COG0142	geranyltranstransferase activity
SAM23877_RS33635	COG0702	epimerase
SAM23877_RS33645	COG1595	DNA-templated transcription, initiation
SAM23877_RS33685	COG1028	Short-chain dehydrogenase reductase Sdr
SAM23877_RS33695	COG1609	Transcriptional regulator
SAM23877_RS33710	COG3250	beta-galactosidase activity
SAM23877_RS33730	COG1278	Cold shock
SAM23877_RS33735	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SAM23877_RS33750	COG2197	response regulator
SAM23877_RS33755	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SAM23877_RS33780	COG2124	cytochrome p450
SAM23877_RS33805	COG0604	alcohol dehydrogenase
SAM23877_RS33805	COG3321	synthase
SAM23877_RS33825	COG1131	(ABC) transporter
SAM23877_RS33835	COG4585	Histidine kinase
SAM23877_RS33840	COG2197	response regulator
SAM23877_RS33850	COG3321	synthase
SAM23877_RS33850	COG0604	alcohol dehydrogenase
SAM23877_RS33890	COG1028	Short-chain dehydrogenase reductase Sdr
SAM23877_RS33895	COG4948	Mandelate Racemase Muconate Lactonizing
SAM23877_RS33910	COG1132	(ABC) transporter
SAM23877_RS33915	COG3848	Pyruvate phosphate dikinase
SAM23877_RS33915	COG0574	Belongs to the PEP-utilizing enzyme family
SAM23877_RS33920	COG4709	membrane
SAM23877_RS33945	COG1366	Belongs to the anti-sigma-factor antagonist family
SAM23877_RS33950	COG0596	Alpha beta hydrolase
SAM23877_RS33970	COG3896	Chloramphenicol phosphotransferase-like protein
SAM23877_RS33975	COG1595	DNA-templated transcription, initiation
SAM23877_RS33980	COG2353	YceI-like domain
SAM23877_RS33990	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SAM23877_RS33995	COG3766	membrane
SAM23877_RS34030	COG1127	ABC transporter
SAM23877_RS34040	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SAM23877_RS34065	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SAM23877_RS34100	COG1960	acyl-CoA dehydrogenase activity
SAM23877_RS34115	COG4106	trans-aconitate 2-methyltransferase activity
SAM23877_RS34145	COG0765	amino acid transport
SAM23877_RS34150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAM23877_RS34165	COG0765	amino acid transport
SAM23877_RS34175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SAM23877_RS34180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAM23877_RS34185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAM23877_RS34190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAM23877_RS34195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAM23877_RS34205	COG0431	NADPH-dependent FMN reductase
SAM23877_RS34210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SAM23877_RS34235	COG0745	RESPONSE REGULATOR receiver
SAM23877_RS34260	COG0456	acetyltransferase
SAM23877_RS34270	COG1028	Short-chain dehydrogenase reductase Sdr
SAM23877_RS34280	COG0842	Transport permease protein
SAM23877_RS34280	COG1129	ABC transporter
SAM23877_RS34290	COG1472	Belongs to the glycosyl hydrolase 3 family
SAM23877_RS34330	COG0778	Nitroreductase
SAM23877_RS34360	COG1028	Short-chain dehydrogenase reductase Sdr
SAM23877_RS34365	COG3321	synthase
SAM23877_RS34365	COG0604	alcohol dehydrogenase
SAM23877_RS34380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SAM23877_RS34410	COG2182	Extracellular solute-binding protein
SAM23877_RS34415	COG1175	transmembrane transport
SAM23877_RS34420	COG0395	ABC-type sugar transport system, permease component
SAM23877_RS34425	COG2723	6-phospho-beta-galactosidase activity
SAM23877_RS34430	COG1959	2 iron, 2 sulfur cluster binding
SAM23877_RS34615	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SAM23877_RS34645	COG4521	taurine ABC transporter
SAM23877_RS34650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SAM23877_RS34655	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SAM23877_RS34685	COG1028	Short-chain dehydrogenase reductase Sdr
SAM23877_RS34700	COG0604	alcohol dehydrogenase
SAM23877_RS34700	COG1028	Short-chain dehydrogenase reductase Sdr
SAM23877_RS34700	COG3321	synthase
SAM23877_RS34720	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SAM23877_RS34730	COG0667	Aldo Keto reductase
SAM23877_RS34740	COG2353	YceI-like domain
SAM23877_RS34750	COG1959	2 iron, 2 sulfur cluster binding
SAM23877_RS34760	COG3335	DDE superfamily endonuclease
SAM23877_RS34790	COG3547	Transposase (IS116 IS110 IS902 family)
SAM23877_RS34800	COG3335	DDE superfamily endonuclease
SAM23877_RS34850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SAM23877_RS34860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SAM23877_RS34865	COG0318	PFAM AMP-dependent synthetase and ligase
SAM23877_RS34875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SAM23877_RS34880	COG0604	alcohol dehydrogenase
SAM23877_RS34880	COG1028	Short-chain dehydrogenase reductase Sdr
SAM23877_RS34880	COG3321	synthase
SAM23877_RS34885	COG0640	Transcriptional regulator
SAM23877_RS34890	COG1028	Short-chain dehydrogenase reductase Sdr
SAM23877_RS34905	COG1280	lysine exporter protein (LysE YggA)
SAM23877_RS34935	COG3293	Transposase
SAM23877_RS34950	COG1309	transcriptional regulator
SAM23877_RS34955	COG4221	oxidoreductase activity
SAM23877_RS34965	COG0667	Aldo Keto reductase
SAM23877_RS34990	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SAM23877_RS34995	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SAM23877_RS35000	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SAM23877_RS35040	COG1309	transcriptional regulator
SAM23877_RS35045	COG0110	maltose O-acetyltransferase activity
SAM23877_RS35065	COG0583	DNA-binding transcription factor activity
SAM23877_RS35095	COG1733	regulation of RNA biosynthetic process
SAM23877_RS35125	COG1278	Cold shock
SAM23877_RS35145	COG3335	DDE superfamily endonuclease
SAM23877_RS35175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SAM23877_RS35180	COG1522	sequence-specific DNA binding
SAM23877_RS35190	COG1309	transcriptional regulator
SAM23877_RS35235	COG1733	regulation of RNA biosynthetic process
SAM23877_RS35255	COG3226	Transcriptional regulator
SAM23877_RS35275	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SAM23877_RS35290	COG3629	intracellular signal transduction
SAM23877_RS35305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SAM23877_RS35310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SAM23877_RS35370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SAM23877_RS35455	COG0154	amidase activity
SAM23877_RS35465	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SAM23877_RS35475	COG0745	RESPONSE REGULATOR receiver
SAM23877_RS35495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SAM23877_RS35515	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SAM23877_RS35520	COG3629	intracellular signal transduction
SAM23877_RS35520	COG3903	Transcriptional regulator
SAM23877_RS35525	COG1028	Short-chain dehydrogenase reductase Sdr
SAM23877_RS35555	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SAM23877_RS35660	COG0494	nUDIX hydrolase
SAM23877_RS35700	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SAM23877_RS35725	COG0513	Belongs to the DEAD box helicase family
SAM23877_RS35730	COG1278	Cold shock
SAM23877_RS35805	COG2770	Histidine kinase
SAM23877_RS35805	COG2208	phosphoserine phosphatase activity
SAM23877_RS35825	COG1335	isochorismatase
SAM23877_RS35840	COG1278	Cold shock
SAM23877_RS35905	COG0829	nickel cation binding
SAM23877_RS35910	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SAM23877_RS35920	COG0804	urea catabolic process
SAM23877_RS35925	COG0831	urea catabolic process
SAM23877_RS35925	COG0832	Belongs to the urease beta subunit family
SAM23877_RS35935	COG0596	Alpha beta hydrolase
SAM23877_RS35940	COG2208	phosphoserine phosphatase activity
SAM23877_RS35940	COG2770	Histidine kinase
SAM23877_RS35980	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SAM23877_RS36035	COG0702	epimerase
SAM23877_RS36050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SAM23877_RS36100	COG2514	catechol 2,3-dioxygenase activity